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the identities $xx=0$ and $xy=-yx$.) Here, by a [non-associative algebra]{} we mean a vector space equipped with a bilinear operation. In a variety of algebras ${\ensuremath{\mathcal{V}}}$ which is a semi-abelian category—for instance, ${\ensuremath{\mathcal{V}}}$ could be any variety of non-associative algebras—for any object $B$ the functor $B\flat (-)\colon{{\ensuremath{\mathcal{V}}}\to {\ensuremath{\mathcal{V}}}}$ takes an object $X$ and sends it to the kernel $B\flat X$ of the universally induced morphism ${\lgroup}1_B\;0{\rgroup}\colon B+X\to B$. As explained in [@BJK; @Bourn-Janelidze:Semidirect], functors of this kind play a key role in the description of *internal actions* (which correspond to split extensions via a semi-direct product construction) as algebras for a monad. It also appears in a characterisation of the concept of a [locally algebraically cartesian closed (LACC)]{} category [@GrayPhD; @Gray2012; @Bourn-Gray]. The variety ${\ensuremath{\mathcal{V}}}$ is such, if and only if each functor $B\flat (-)\colon{{\ensuremath{\mathcal{V}}}\to {\ensuremath{\mathcal{V}}}}$, equivalently, 1. is a left adjoint; 2. preserves all colimits; or 3. preserves binary sums. This condition has some strong categorical-algebraic consequences, as explored in the above-mentioned papers and in [@acc]. In the article [@GrayLie], Gray proved that the variety ${\ensuremath{\mathsf{Lie}}_{{\ensuremath{\mathbb{K}}}}}$ of Lie algebras over a field ${\ensuremath{\mathbb{K}}}$ is a [[(LACC)]{}]{} category. (Actually, he proved it for Lie algebras over a commutative ring with unit.) In our article [@GaVa-LACC] we managed to find a partial converse to this theorem: we showed that the condition [[(LACC)]{}]{} characterises Lie algebras amongst ${\ensuremath{\mathbb{K}}}$-algebras with an alternating multiplication ($xx=0$). The result is a simple categorical description of the Jacobi identity. We did, however, fail to remove the requirement that the identity $xx=0$ must hold. At the same we failed to understand why a subvariety of the variety of Lie algebras cannot be a locally algebraically cartesian closed category, unless its algebras carry the zero product. (In other words: unless $xy=0$ is an identity, which is equivalent to saying that the category is abelian.) The purpose of our present paper is to clarify those two issues. We present a new and self-contained analysis of the condition [[(LACC)]{}]{} for categories of non-associative algebras, with the concrete aim of proving that over an infinite field ${\ensuremath{\mathbb{K}}}$ of characteristic different from $2$, there is precisely one non-abelian example: the category ${\ensuremath{\mathsf{Lie}}_{{\ensuremath{\mathbb{K}}}}}$ of Lie algebras over ${\ensuremath{\mathbb{K}}}$. In Section \[Section Preliminaries\] we start by recalling some definitions and basic properties of varieties of non-associative algebras, with in particular an analysis of the objects $B\flat X$ in this context. This leads to Theorem \[Theorem previous\] which provides a summary of the main result of [@GaVa-LACC]. Section \[Section Commutative\] is devoted to the commutative case. We actually prove that *there is no commutative case*: if ${\ensuremath{\mathbb{K}}}$ is an infinite field of characteristic different from $2$ and ${\ensuremath{\mathcal{V}}}$ is a variety of commutative ${\ensuremath{\mathbb{K}}}$-algebras that forms a [[(LACC)]{}]{} category, then ${\ensuremath{\mathcal{V}}}$ is an abelian category (Theorem \[Theorem Commutative\]). As a consequence we obtain Corollary \[Corollary degree 2\], which says that any variety of ${\ensuremath{\mathbb{K}}}$-algebras satisfying an identity of degree $2$ is a subvariety of ${\ensuremath{\mathsf{Lie}}_{{\ensuremath{\mathbb{K}}}}}$ as soon as it is a [[(LACC)]{}]{} category. In characteristic $2$ we prove a version of Corollary \[Corollary degree 2\] for the variety ${\ensuremath{\mathsf{qLie}}_{{\ensuremath{\mathbb{K}}}}}$ of [quasi-Lie algebras]{}, which by definition satisfies the Jacobi identity and the identity $xy=yx=-yx$ (Corollary \[Corollary qLie\]). Section \[Section General Case\] contains this paper’s first major result, Theorem \[Theorem degree 3\]. It says that, in characteristic zero, Corollary \[Corollary degree 2\] does in fact describe the general case, since *a variety of non-associative algebras which doesn’t satisfy any non-trivial identity of degree $2$ cannot be a [[(LACC)]{}]{} category*. The proof of this result involves a system of 128 polynomial equations $(f_i=0)_{1\leq i \leq 128}$—see Appendix \[Appendix\]. In order to show that the system is inconsistent, we had to rely on a computer algebra system; we chose to use an open-source package called <span style="font-variant:small-caps;">Singular</span> [@DGPS]. In Section \[Section Prime Characteristic\] we extend this to infinite fields of prime characteristic, adapting the approach in characteristic zero to a proof of Theorem \[Theorem degree 3 prime\]. In Section \[Section Subvarieties\] we combine these results with a proof that *a variety of non-associative ${\ensuremath{\mathbb{K}}}$-algebras which is strictly smaller than ${\ensuremath{\mathsf{Lie}}_{{\ensuremath{\mathbb{K}}}}}$ can only form a [[(LACC)]{}]{} category when it forms an abelian category* in order to obtain Theorem \[Theorem Lie\]: *a variety of non-associative ${\ensuremath{\mathbb{K}}}$-algebras which forms a non-abelian [[(LACC)]{}]{} category is either the variety of Lie algebras over ${\ensuremath{\mathbb{K}}}$ (when ${\ensuremath{\mathrm{char}}}({\ensuremath{\mathbb{K}}})\neq 2$) or one of the varieties ${\ensuremath{\mathsf{Lie}}_{{\ensuremath{\mathbb{K}}}}}$ and ${\ensuremath{\mathsf{qLie}}_{{\ensuremath{\mathbb{K}}}}}$ (when ${\ensuremath{\mathrm{char}}}({\ensuremath{\mathbb{K}}})= 2$)*. This result is then further sharpened in Section \[Section n-Ary\] where we prove that a variety of $n$-algebras viewed as a non-abelian semi-abelian category can only be [[(LACC)]{}]{} when $n=2$—so that it is ${\ensuremath{\mathsf{Lie}}_{{\ensuremath{\mathbb{K}}}}}$ or ${\ensuremath{\mathsf{qLie}}_{{\ensuremath{\mathbb{K}}}}}$. This is our main result, Theorem \[Theorem n-Ary\]. To conclude the article, in Section \[Section Final Remarks\] we make a number of final remarks on potential ways of extending our results to more general situations. Preliminaries {#Section Preliminaries} ============= Non-associative algebras ------------------------ Let ${\ensuremath{\mathbb{K}}}$ be a field. A [(non-associative) algebra $A$ over ${\ensuremath{\mathbb{K}}}$]{} is a ${\ensuremath{\mathbb{K}}}$-vector space equipped with a bilinear operation ${A\times A\to A}$. We write ${\ensuremath{\mathsf{Alg}}}_{{\ensuremath{\mathbb{K}}}}$ for the category of non-associative algebras over ${\ensuremath{\mathbb{K}}}$, with linear maps between them that preserve the operation. A [variety]{} of non-associative algebras is any equationally defined class of algebras, considered as a full subcategory ${\ensuremath{\mathcal{V}}}$ of ${\ensuremath{\mathsf{Alg}}}_{{\ensuremath{\mathbb{K}}}}$. The variety ${\ensuremath{\mathsf{Lie}}_{{\ensuremath{\mathbb{K}}}}}$ of [Lie algebras]{} over ${\ensuremath{\mathbb{K}}}$ is the variety of non-associative algebras with a multiplication that is [alternating]{} ($xx = 0$) and such that the [Jacobi identity]{} $${x(yz)+z(xy)+ y(zx)=0}$$ holds. Next to the Jacobi identity, instead of being alternating, the objects in the variety ${\ensuremath{\mathsf{qLie}}_{{\ensuremath{\mathbb{K}}}}}$ of [quasi-Lie algebras]{} [@quasiLie] over ${\ensuremath{\mathbb{K}}}$ satisfy [anticommutativity]{} ($xy =- yx$). As long as the characteristic of the field ${\ensuremath{\mathbb{K}}}$ is different from $2$, these two varieties coincide. However, when ${\ensuremath{\mathrm{char}}}({\ensuremath{\mathbb{K}}})=2$, the variety ${\ensuremath{\mathsf{Lie}}_{{\ensuremath{\mathbb{K}}}}}$ is strictly smaller than ${\ensuremath{\mathsf{qLie}}_{{\ensuremath{\mathbb{K}}}}}$. If ${\ensuremath{\mathcal{V}}}$ satisfies commutativity $xy=yx$ instead of being alternating, it is the variety of so-called [mock–Lie algebras]{}—see [@MR3598575] for a survey on this type of algebras. As is common for Lie algebras, we call an
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, they suspend the critique which the successful esthetic totality exerts against the flawed one of society. —T. W. Adorno, Essays on Music, trans. Susan H. Gillespie, ed. Richard Leppert (Berkeley: University of California Press, 2002), p. 291. [Great modernist composers like Berg, Schönberg, and Webern] are called individualists [by other Marxists], and yet their work is nothing but a single dialogue with the powers that destroy individuality—powers whose "formless shadows" fall gigantically on their music. In music, too, collective powers are liquidating an individuality past saving, but against them only individuals are capable of consciously representing the aims of collectivity. —T. W. Adorno, Essays on Music, trans. Susan H. Gillespie, ed. Richard Leppert (Berkeley: University of California Press, 2002), p. 315. For Chapter 18 Let Scott, Balzac, and Dreiser serve as the non-chronological markers of the emergence of realism in its modern form; these first great realisms are characterized by a fundamental and exhilarating heterogeneity in their raw materials and by a corresponding versatility in their narrative apparatus. In such moments, a generic confinement to the existent has a paradoxically liberating effect on the registers of the text, and releases a set of heterogeneous historical perspectives—the past for Scott, the future for Balzac, the process of commodification for Dreiser—normally felt to be inconsistent with a focus on the historical present. Indeed, this multiple temporality tends to be sealed off and recontained again in "high" realism and naturalism, where a perfected narrative apparatus (in particular the threefold imperatives of authorial depersonalization, unity of point of view, and restriction to scenic representation) begin to confer on the "realistic" option the appearance of an asphyxiating, self-imposed penance. It is in the context of this gradual reification in late capitalism that the romance once again comes to be felt as the place of narrative heterogeneity and freedom from the reality principle to which a now oppressive realistic representation is the hostage. —Fredric Jameson, The Political Unconscious: Narrative as a Socially Symbolic Act (London: Routledge, 2002), p. 90. The Philosophers have only interpreted the world, in various ways; the point, however, is to change it. —Karl Marx, "Eleventh Thesis on Feuerbach" (1845), in The Marx-Engels Reader, ed. Robert C. Tucker (New York: W. W. Norton, 1978), p. 145. Notes CHAPTER 2 Introduction Continued . Anton Chekhov, The Cherry Orchard, trans. Sharon Marie Carnicke (Indianapolis: Hackett, 2010), p. 22. . Henry James, The Ambassadors (New York: Harper & Brothers, 1903), p. 150. . Samuel Johnson, Selected Writings, ed. Peter Martin (Cambridge, MA: Harvard University Press, 2009), p. 369. CHAPTER 3 Ways In and Out of the Hermeneutic Circle . Mark Akenside, The Poetical Works (London: Pickering, 1835), p. 32. CHAPTER 6 The New Criticism and Other Western Formalisms . In William Butler Yeats, New Poems (Dublin: Cualla Press, 1938). . William Empson, Seven Types of Ambiguity (New York: New Directions, 1966), p. 18. . Empson, p. 19. . Empson, p. 192. . F. W. Bateson, Wordsworth: A Re-Interpretation (London: Longmans, Green, 1956). CHAPTER 7 Russian Formalism . Boris Eikhenbaum, "The Theory of the 'Formal Method,' " in Russian Formalist Criticism: Four Essays, ed. and trans. Lee T. Lemon and Marion J. Reis (Lincoln: University of Nebraska Press, 1965), p. 111. . Eikhenbaum, p. 102. . In Roman Jakobson, Verbal Art, Verbal Sign, Verbal Time, ed. Krystyna Pomorska and Stephen Rudy (Minneapolis: University of Minnesota Press, 1985). . Jakobson, 114. . See Matthew Arnold, The Complete Prose Works, Volume IX: English Literature, ed. R. H. Super (Ann Arbor: University of Michigan Press, 1973), pp. 52–53. . Eikhenbaum, 118. . Viktor Shklovsky, Theory of Prose (Normal, IL: Dalkey Archive Press, 1991), 20. . Yuri Tynianov, "On Literary Evolution," in Twentieth Century Literary Theory, ed. Vassilis Lambropoulos and David Neal Miller (Albany: SUNY Press, 1987), 162. CHAPTER 8 Semiotics and Structuralism . Edward Estlin Cummings, 100 Selected Poems (New York: Grove Press, 1994), p. 79. CHAPTER 9 Linguistics and Literature . Roman Jakobson, "Two Types of Aphasia and Two Types of Language Disturbance," in Roman Jakobson and Morris Halle, Fundamentals of Language (The Hague: Mouton, 1956), pp. 69–96. CHAPTER 10 Deconstruction I . William H. Pritchard, "The Hermeneutical Mafia or, After Strange Gods at Yale," Hudson Review 28.4 (1975): 601–610. . Roland Barthes, The Eiffel Tower and Other Mythologies (New York: Hill and Wang, 1984), pp. 3–17 (4). . Michel de Certeau, "Walking in the City," in The Practice of Everyday Life (Berkeley: University of California Press, 1988). CHAPTER 15 The Postmodern Psyche . Jean-François Lyotard, The Inhuman (Stanford: Stanford University Press, 1991). CHAPTER 25 The End of Theory? . Umberto Eco, "Peirce's Notion of the Interpretant," MLN 91.6 (1976): 1457–1472. The Varieties of Interpretation A Guide to Further Reading in Literary Theory STEFAN ESPOSITO Literary theory questions the conditions and assumptions that inform interpretation. This is evidenced in the types of questions that theory asks. How do we interpret the link between an author's thought process and the text that appears on paper? How do we interpret the significance of political and economic factors in a lyric poem? Should the gender, race, or sexuality of an author shape the way we read a novel? The focus of discrete critical schools differs significantly, but all humanistic studies that question the nature of interpretation share a common ancestor in the secularization of hermeneutics. Students wishing to deepen their understanding of literary theory would do well to consider this tradition before branching into other theories of literary and cultural interpretation. Friedrich Schleiermacher is a foundational figure in the development of modern hermeneutics. In works such as On Religion: Speeches to Its Cultured Despisers (1799), Soliloquies (1800; 2nd ed., 1810), Outlines of a Critique of Previous Ethical Theory (1803), and The Christian Faith (1821–1822, rev. ed., 1830–1831), Schleiermacher expanded the domain of serious interpretation from hermetic arguments about sacred texts to all spheres of human communication. Following Johann Gottfried Herder, Schleiermacher argues that all thought is dependent on and bounded by, or identical with, language. Accordingly, he proposed that hermeneutics should be a universal discipline, applicable to law as well as literature, to oral as well as written texts, and to modern as well as ancient sources. For a good English translation of Schleiermacher's writings relevant to literary and philosophical hermeneutics, see Hermeneutics and Criticism and Other Writings, trans. Andrew Bowie (Cambridge: Cambridge University Press, 1998). Schleiermacher is also responsible for one of the first modern treatises on translation theory, On the Different Methods of Translation (1813). A summary of the intersections among romantic hermeneutics, literary theory, and translation studies is found in the introduction to The Translation Studies Reader, ed. Lawrence Venuti (London: Routledge, 2004). Following in Schleiermacher's footsteps, but informed by Leopold von Ranke's historicism, Wilhelm Dilthey attempted to turn hermeneutics into a modern experimental science involving the interpretive equivalent of hypothesis testing. In The Formation of the Historical World in the Human Sciences (1910), ed. Rudolf A. Makkreel and Frithjof Rodi (Princeton: Princeton University Press, 2002), Dilthey argued that interpretation involves an indirect or mediated understanding that can be attained only by placing human expressions in their historical context. In this account, understanding is not a process of reconstructing the state of mind of the author, but one of articulating what is expressed in the work. Jos de Mul, The Tragedy of Finitude: Dilthey's Hermeneutics of Life, trans.
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any class, but it could not summon them without having prior sanction of central or state government or the district magistrate. The Department of Information Technology, in its report, granted saction to proceed against the 21 companies for allegedly promoting enmity between classes and causing prejudice to national integration. The report said, "The documents and contents therein are in the nature to instigate enmity between different groups on the ground of religion, race, place of birth, residence, language and doing acts prejudicial to the maintenance of harmony...." It said the contents were provocative and were prejudicial to national integration. The report said in view of the documents and confirmation of availability of such contents on the website/ search engines as reported by Station House Officer of Tughlak Road police station, the sanctioning authority, Government of India, was satisfied that such content was violative of the provisions of the Information Technology (Intermediary Guidelines) Rules 2011. It said after due application of "judicious mind", it was found appropriate to grant sanction under section 196 of CrPC to proceed against the accused persons in the aforesaid complaint keeping in view national harmony, integration and national interest. The report said that they had held four meetings with the representatives of social networking sites and search engines Google, Facebook, Yahoo and Microsoft. "The availability of objectionable content on their websites and their search results through the search engine was brought to their knowledge. The objectionable and defamatory content was also shown to them and they were requested to take appropriate action in the public interest, national harmony and integration....," it said. The report said even in August last year, the availability of similar content on such websites was brought to the notice of the Department of Information Technology. Meanwhile, the court today issued directions to the MEA after the counsel appearing for Facebook India said over ten out of the 21 companies were foreign based and the court would have to issue process to serve the summons to them. The magistrate directed the MEA to get the summons served saying, "Let the process (to serve the summons) to (foreign based) accused be sent through MEA as per the process." The court has now listed the matter for further hearing on March 13 and has directed the accused to appear in person on the next date. "The accused are allowed exemption for today only but are directed to appear in person on the next date of hearing without fail," the magistrate said. The court's order came after advocate Shashi Tripathi, appearing for complainant Vinay Rai, said he would file a fresh list of addresses of these foreign-based sites in the court. During the hearing, senior advocate Siddharth Luthra, representing Facebook India, sought adjournment for the day saying the matter is pending before the Delhi High Court and the case file is also in the High Court. He said that one of the accused, who is chairman of the Facebook, is based in California in USA and the court will have to direct the MEA for serving summons on him. The counsel for Google India Pvt Ltd also asked the court to adjourn the matter today. He said that summons issued to accused companies Orkut, YouTube and Blogspot have been mistakenly served at their premises here. Some of the accused companies had also moved the High Court against the summons issued to them. The magistrate's December 23 order had come three days after another court in a civil case had restrained these sites including Facebook, Google and YouTube from webcasting any "anti-religious" or "anti-social" content promoting hatred or communal disharmony..action .asp .aspx .cfm .do .htm .html .jsp .page .php .war Adverse reactions to contrast media: an analysis from spontaneous reporting data. Diagnostic contrast media (CM) are a widely used class of drugs with poor information regarding their safety. Nevertheless, epidemiological studies showed that CM cause adverse reactions commonly considered unpreventable and unavoidable. Because spontaneous reporting is a valuable methodology for better defining the safety profile of drugs after their approval, we analyzed the spontaneous reports of suspected adverse reactions attributed to CM sent to the Sicilian Regional Centre for the Spontaneous Reporting of Adverse Drug Reactions (ADRs) during the period from 1996 to 2006, with the aim to identify their most important features. One hundred ADR reports out of 3471 involved CM (2.9%); 29 reports were serious, including 1 fatal case. Skin, respiratory system and gastrointestinal tract were most frequently affected sites. The majority of reports described hypersensitivity reactions with immediate onset. Iopromide (52.5%), iopamidol (13.9%) and iomeprol (11.9%) were the drugs with the highest number of reports. Case reports collected by the Sicilian Regional Centre showed that CM adverse reactions are not common or not commonly signalled; however, in agreement with previous published reports, analysis of data suggests that they are generally allergic-like reactions. Further investigations are needed within post-marketing surveillance to identify and prevent the consequences of CM adverse reactions and interactions. Awareness about CM safety should be promoted among all healthcare professionals.You are here The most dangerous place for a woman? Her home More than half of all female homicide victims worldwide — 137 every day — were killed by a member of their own family last year, according to a new United Nations study. Research published by the UN’s Office on Drugs and Crime (UNODC) found that of the approximately 87,000 women and girls intentionally killed in 2017, about 58 per cent died at the hands of someone who was either an “intimate partner” or a relative. This amounts to six women being killed every hour by people they know, the report said. It was released on Sunday to coincide with the UN’s International Day for the Elimination of Violence against Women. The campaign brought thousands of people to the streets of nations around the globe to raise awareness of gender-based violence. Yury Fedotov, the UNODC’s executive director, noted that while the vast majority of worldwide homicide victims are men — accounting for eight out of 10 homicides in 2017 — women bear the greatest burden in terms of violence perpetrated by intimate partners. In 2017, roughly 82 per cent of victims of homicide perpetrated by intimate partners or family members were female. The corresponding figure for men: 18 per cent. The vast majority of men are killed by strangers. “Women continue to pay the highest price as a result of gender inequality, discrimination and negative stereotypes,” Fedotov said. “Targeted criminal justice responses are needed to prevent and end gender-related killings,” he added. The study notes that even though “countries have taken action to address violence against women and gender-related killings in different ways, by adopting legal changes, early interventions and multiagency efforts, as well as creating special units and implementing training in the criminal justice system... there are no signs of a decrease in the number of gender-related killings of women and girls”. The global average, 1.3 female homicide victims per 100,000 female population, has been stable for more than half a decade. However, there are regional variations. Africa and the Americas were the regions where women are most at risk of being killed by intimate partners or family members, the study found. In Africa, the rate was around 3.1 victims per 100,000 female population. In the Americas, it was 1.6 victims. The lowest rate was found in Europe, with 0.7 victims per 100,000 female population. In Madrid on Sunday, demonstrators chanted, “No more victims!” as they marched through the centre of Spain’s capital city. In Istanbul, police fired several rounds of tear gas at protesters during an event against domestic violence. There were also marches and rallies in support of women’s right in Greece, France and Italy. During a diplomatic summit in Brussels over the weekend, Antonio Tajani, the president of the European Parliament, smeared red make-up under his eye in a symbolic act intended to express empathy with women. “Violence against women is unacceptable. I learned this from my mother and I’m teaching it to my children,” he later Tweeted. Canada’s Prime Minister Justin Trudeau released a statement. “Gender-based violence harms us all. It affects families, schools, and workplaces — and holds back whole communities from reaching their full potential,” he said. The UN is sponsoring 16 days of activism aimed at eliminating violence against women. Among its suggestions: Listen to survivors. The Jordan Times The Jordan Times is an independent English-language daily published by the Jordan Press Foundationsince October 26, 1975. The Jordan Press Foundation is a shareholding company listed on the Amman Stock Exchange.Post navigation Raina Telgemeier’s Ghosts Raina Telgemeier is back with her fourth original graphic novel, and we’re all the richer for it. This week marks the release of Ghosts, and in it she explores the nature of family and friendship against a backdrop of self-discovery and the Mexican Día de los Muertos (Day of the Dead) holiday. It’s easy to forget that Raina’s first original book, Smile, came out as recently as 2010. That’s because the effect she’s had makes it hard to remember what graphic novels were like beforehand. Really, it’s hard to recall what the publishing industry in general was like. Before Raina, graphic novels were largely thought to be a highly niche market dominated by superheroes. Aside from
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Bill) is played by Fijian Islander Manu Tupou (who popped up briefly again as the pawnbroker in the excellent Payback). Pretty Calf has been renamed Running Deer and is played by a Greek, Corinna Tsopei, attractive in a sweet way. Some of the actors in the smaller parts were American Indian, however, and the movie was partially shot on location in South Dakota. Some of the Robert B Hauser photography, especially early shots of Indians running, is very classy. Irishman woos Greek Mr. Harris is, early in the picture, often seen pinkly naked and this heightens his vulnerability and non-person status. The movie centers on the famous and deeply unpleasant scene of initiation which involves Harris being hauled up in the air on rawhide thongs attached to knives inserted in his pectorals. This rite is completely invented; it was not in the Johnson story and was never practiced by either Crow or Sioux. It has a lurid and salacious ring to it and has always put me off the film. The film is one of those which irritatingly claims to be authentic and factual historically. It is nothing of the kind. As I have so often said in this blog, I have no objection to Western movies distorting historical truth – they are there to tell an exciting story, not give you a history lesson – but when they mendaciously claim to tell the factual truth, then I do object. He looks more Fijian than Sioux There are other changes. The film invents another captive, Batise (third-billed Jean Gascon) who conveniently speaks English and French – which of course was perfectly possible – and that overcomes Harris’s language problems. In the movie, unlike the story, he never really learns the lingo. (The decision to have a lot of Sioux dialogue with no subtitles was a brave one but was the right way to go; it highlights Horse’s isolation, and we can anyway usually infer what is meant.) Horse kills two enemy Indians, Shoshone, in the film and scalps one. Makes it a bit bloodier. One detail, however, is gorier in the book than the on the screen: old Greasy Hand beheads an annoying dog in the story. Pierced pecs are one thing, but showing a pooch killed on screen, such horrors would never do, so that was quietly dropped. The director was Elliot Silverstein, who had only done one other Western - and that was Cat Ballou. By the way, long before Richard Harris, a 1958 episode of Wagon Train also used the story (this time it was Yellow Rope for some reason, played by Hollywood’s resident Indian chief, Aussie Michael Pate) and used the same title, A Man Called Horse. It had as Horse Ralph Meeker – Roy Anderson in The Naked Spur and Lt. Driscoll in The Run of the Arrow, another lurid Indian-rites flick with an overacting star not suited to Westerns. Thursday, November 28, 2013 The Western, like jazz, was in origin a specifically American genre. The two could almost be thought of as the defining American genres. But both had a huge impact outside America. The Western, any more than jazz, does not belong exclusively to Americans. Europeans, especially, have been and still are writers of Western stories and makers of Western movies as well as readers of Western fiction and avid moviegoers. Long before the spaghetti westerns of the 1960s, the French, British and Germans, among others, were producing novels and motion pictures. In France, in 1896 Gabriel Veyre shot Repas d’Indien (Indian banquet) for the Lumière brothers and Joe Hamman starred as Arizona Bill in films made in the horse country of the Camargue in 1911. The book Il était une fois... le western européen : 1901-2008by Jean-François Giré (2008) gives a whole history of the Western in France and Europe. The modern sport of fast draw first became popular in France (and figured in the 1908 Olympics…) New Lucky Luke and Blueberrybandes dessinées are eagerly sought at the FNAC. French hip hop and rap artist MC Solaar had a great track, Nouveau Western, on his 1994 album Prose Combat. Arizona Bill, Lucky Luke, Blueberry, MC Solaar: French Western heroes In Italy, Puccini’s opera La Fanciulla del West (The Girl of the Golden West) was first performed in 1910, was filmed twice as a silent movie (which must have been odd) and twice as a talkie – or singie. Sergio Leone’s father directed the silent La Vampira Indiana in 1913 (with Sergio’s mamma as the title Indian princess). Il western italiano, a bookby Alberto Pezzotta (2012) tells the story of the whole Italian Western experience. Francesco de Gregori’s wonderful album Bufalo Bill(1976) is an Italian hymn to the West and one of my favorite CDs. In Germany, already in the 1890s Karl May was writing enormously popular Western stories starring Old Shatterhand, made into silent movies in the 1920s (when 1920s Bela Lugosi also starred in German films as Uncas), and Shatterhand and Surehand B-movies filmed in Yugoslavia, starring Lex Barker and Stewart Granger, were big hits in the 1960s. Yeehar, Karl In the UK, Buffalo Bill’s Wild West show was a monster hit in British (and many other European) towns and much appreciated by Queen Victoria and the Prince of Wales. The first color Western was British (Fate, 1911). Silent Westerns were enormously popular and Tom Mix was fêted as a hero on his visit to London. British or semi-British Westerns like The Sheriff of Fractured JaworThe Savage Guns pre-dated spaghettis by several years. The leading authority on Wild Bill Hickok, Joseph G Rosa, was from Ruislip, Middlesex. Tom Mix in England fêted by small boys of all ages In 1971, Edwin Sherin directed Burt Lancaster in the Elmore Leonard story Valdez Is Coming. How American can you get? It was filmed in Spain. When Tombstone and Wyatt Earp were being made in the early 1990s, where did Wyatt Earp have to get its costumes from? Europe. Not that Howard Hughes, surely? European directors of Westerns like Fritz Lang, cinematographers like Roger Deakins, writers like Alan Sharp have all contributed enormously to the development of the genre. Hope you caught Der Schatz im Silbersee back in '62 All over Europe you can find Western film festivals, dude ranches, rodeos, line dancing, fast draw competitions and every kind of Western event. European moviegoers await new Westerns as eagerly as they do Stateside. Wednesday, November 27, 2013 Crossfire Trail is really an excellent film. Tom Selleck’s production company TWS teamed up with Simon Wincer (Ozzie director of Selleck in Quigley Down Under and before that the great Lonesome Dove) and a couple of good Dove actors (Barry Corbin, William Sanderson) to make a seriously classy TV Western. Selleck made his mark back in 1979 in a TV oater, The Sacketts, based on the Louis L’Amour novels, and then in another L’Amour tale, The Shadow Riders, also for TV, in 1982. Later, round about the turn of the century, he made a nice little series of such movies, such as Last Stand at Saber River, Crossfire Trail andMonte Walsh. They were all good, some outstanding. The novel Saber River had been based on a high-quality Elmore Leonard novel but for Crossfire Selleck went back to L’Amour, a 1954 book, L’Amour’s eighth. It tells of a tough, decent Rafe (for Rafael) Covington, who makes a promise to a dying friend that he will take care of his ranch in Wyoming – and his widow. Selleck very good. He convinces. It was originally aired on TNT on January 21, 2001 and was enormously popular, securing over 12 million viewers. Justifiably so, because it is very well done. Why? Well, one reason is Selleck himself. He really looked the part and his decent tough-guy act was just right for a gritty Westerner with his mind set on doing what a man’s gotta do. Another reason is the support acting, especially of Barry Corbin as the bought-and-paid-for sheriff. He had aged somewhat from his bumbling Roscoe in Lonesome Dove and is now gray-bearded, even plumper and absolutely superb. He
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have custom controls that use a different naming convention for delegates, they won't be bound automatically and you will need to bind them programmatically. The binding mechanism relies on Objective-C runtime protocol detection, so it won't work for Swift protocols that aren't @objc-compliant. If you have multiple views in your layout that all use the same delegate protocol, e.g. several UIScrollViews or several UITextFields, then they will all be bound to the view controller. If you are only interested in receiving events from some views and not others, you can either add logic inside the delegate methods to determine which view is calling them, or explicitly disable the delegate properties of those views by setting them to nil: <UITextFielddelegate="nil"/> You can also set the delegate to a specific object by passing a reference to it as a state variable or constant and then referencing that in your delegate expression: Note: There is currently no safe way to explicitly bind a delegate to the layoutNode's owner class. Attempting to pass self as a constant or state variable will result in a retain cycle (which is why owner-binding is done implicitly rather than manually). Animation UIKit has great support for animation, and naturally you'll want to include animations in your Layout-based interfaces, so how do you handle animation in Layout? There are three basic types of animation in iOS: Block-based animations, using UIView.animate(). Normally you would use this in UIKit by setting view properties and/or AutoLayout constraints inside an animation block. In Layout you should call setState() inside an animation block to implicitly animate any changes resulting from the state change: Animated setters. Some properties of UIViews have an animated setter variant that automatically applies an animation when called. For example, calling UISwitch.setOn(_:animated:) will animate the state of the switch, whereas setting the on property directly will update it immediately. Layout does not expose the setOn(_:animated:) method in XML, however if you have an expression for <UISwitch isOn="onState"/> then you can cause it to be updated with an animation by calling setState(_:animated:): self.layoutNode?.setState(["onState":true], animated: true) Using the animated argument of setState() will implicitly call the animated variant of the setter for any property that is affected by the update. Properties that don't support animation will be set as normal. User-driven animation. Some animation effects are controlled by the user dragging or scrolling. For example, you might have a parallax effect when scrolling that causes several views to move in various directions or speeds in sync with the scroll. To implement this kind of animation in Layout, call setState() inside the scroll or gesture handler, passing any parameters needed for the expressions that position the animated views. You can either implement the animation logic in Swift and pass the results as a state, or compute the animation state using expressions in your Layout XML - whichever works best for your use-case, e.g. Safe Area Insets iOS 11 introduced the concept of the safe area - a generalization of the top and bottom layout guides that were provided before for insetting content to account for status, navigation and tool/tab bars. In order to prevent you from needing to include conditional compilation logic in your templates, Layout makes the iOS 11 safeAreaInsets property available across all iOS versions (falling back to using layout guides as the underlying implementation on iOS 10 and earlier). To position a view inside the safe area of its parent, you could write: Note: The value for safeAreaInsets exposed by Layout differs slightly from the documented behavior for UIView.safeAreaInsets: Apple states that the safeAreaInsets value accounts for the status bar and other UI such as navigation or toolbars, but only for the root view of a view controller. For subviews, the insets reflect only the portion of the view that is covered by those bars, so for a small view in the middle of the screen, the insets would always be zero since the toolbars or iPhone X notch would never overlap this view. For Layout, this approach creates problems, as your view frame may depend on the safeAreaInsets value, which would in turn be affected by the frame, creating a cyclic dependency. Rather than try to resolve this recursively, Layout always returns insets relative to the current view controller, so even for subviews that do not overlap the screen edges, the value of safeAreaInsets will be the same as for the root view. UIScrollView derives its insets automatically on iOS 11, but this behavior differs from iOS 10. To achieve consistent behavior, you can set the contentInsetAdjustmentBehavior property to never, and then set the contentInset manually: To simplify backwards compatibility, as with the safeAreaInsets property itself, Layout permits you to set contentInsetAdjustmentBehavior on any iOS version, however the value is ignored on iOS versions earlier than 11. Legacy Layout Mode You may have seen references in the code or documentation to the LayoutNode.useLegacyLayoutMode. In the original design of Layout, the right and bottom expressions were specified relative to the top-left corner of the view, rather than relative to their respective edges as you might expect. Version 0.6.22 of Layout introduces a new layout mode where bottom and right expressions are relative to the bottom and right edges, which is more intuitive for users familiar with CSS or AutoLayout, and is also more consistent with the way that the leading and trailing expressions work. To avoid breaking compatibility with existing Layout projects, you must explicitly opt-in to the new layout mode by setting LayoutNode.useLegacyLayoutMode = false in your application code. This is a global property so it only needs to be set once. A good place to do this is in the application(_:didFinishLaunchingWithOptions:) method of your AppDelegate: In a future version of Layout, the new layout mode will become the default and the legacy layout mode will eventually be removed, so it's a good idea to begin migrating your templates now! Expressions The most important feature of the LayoutNode class is its built-in support for parsing and evaluating expressions. The implementation of this feature is built on top of the Expression framework, but Layout adds a number of extensions in order to support UIKit types and layout-specific logic. Expressions can be simple, hard-coded values such as "10", or more complex expressions such as "width / 2 + someConstant". The available operators and functions to use in an expression depend on the name and type of the property being expressed, but all expressions support the standard decimal math and boolean operators and functions that you find in most C-family programming languages. You can also extend Layout with custom functions (see the Functions section below). Expressions in a LayoutNode can reference constants and state passed in to the node or any of its parents. They can also reference the values of any other expression defined on the node, or any supported property of the view: To reference a node that is not an immediate sibling, you can give the node an id attribute, and then reference that node using # followed by the id: <UIView> <UILabelid="first"left="20"text="Foo"/> <UILabelright="20"text="Bar"/> <!-- this label will be aligned with the first label --> <UILabelleft="#first.left"top="previous.bottom + 20"text="Bar" /> </UIView> Layout Properties The set of expressible properties available to a LayoutNode depends on the view type, but every node supports the following properties at a minimum: top left bottom right leading trailing width height center.x center.y Note: see the Legacy Layout Mode section for an important note about the right and bottom layout properties. These are numeric values (measured in screen points) that specify the frame for the view. In addition to the standard operators, all of these properties allow values specified in percentages: <UIViewright="50%"/> Percentage values are relative to the width or height of the parent LayoutNode (or the superview, if the node has no parent). The expression above is typically equivalent to writing the following (unless the parent is a UIScrollView, in which case the contentInset and safe area are also taken into account): <UIViewright="parent.width / 2"> Additionally, the width and height properties can make use of a virtual variable called auto. The auto variable equates to the content width or height of the node, which is determined by a combination of three things: The intrinsicContentSize property of the native view (if specified) Any AutoLayout constraints applied to the view by its (non-Layout-managed) subviews The enclosing bounds for all the children of the node. If a node has no children and no intrinsic size, auto is usually equivalent to 100%, depending on the view type. Though entirely written in Swift, the Layout library makes heavy use of the Objective-C runtime to automatically generate property bindings for any type of view. The available properties therefore depend on the type of view that is passed into the LayoutNode constructor (or the name of the XML node, if you are using XML layouts). Only types that are visible to the Objective-C runtime can be detected automatically
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Lemonade or Lemon Mint Lip Balms for a fun flashback to grade school's flavored lip stuff. Or if you want something slightly less girly, Apothecanna’s Lip Buzz is your jam. Don't worry (or...sorry?), you won’t get high from the cannabis seed oil-based balm. Maybe this is already in your cosmetic bag, but now you know that Obsessive Compulsive Cosmetics' Lip Tars contain hempseed oil to help with the delightfully thin and smooth (but no less pigmented) application. NSFW is a personal favorite. Add-Ons If none of the above products strike your fancy, but you’re interested in the benefits that hemp can bring to your body, investing in some Hemp Protein Powder or Organic Hemp Oil may be all you need. Add the powder to your diet to help increase fiber intake, or the oil to existing beauty products (like shampoos or conditioners). Of course, you can always use it alone as a moisturizer. But if you really want to enjoy Sunday to its fullest, there are many beauty brands out there that are less legal(at least federally), so unsurprisingly, they weren’t too keen on having their brands promoted here. —Elizabeth Brockway Photos by Elizabeth Brockway. Enter here to win! You know the drill—enter your email for a chance to win free skincare and makeup.Blog In part 5 of Under the Radar's 2016 Holiday Gift Guide we offer up some technology and apparel items. They may not seem like obvious bedfellows, but our lead tech item is a wearable speaker system that fills your body with sound. There is also a speaker designed for streaming music and some fun geeky clothing and jewelry. More In part 4 of Under the Radar's 2016 Holiday Gift Guide we offer up some of 2016's most interesting DVDs and Blu-rays. They range from critically acclaimed current TV shows to reissued cult classic films to forgotten TV oddities (including a musical cop show) to David Bowie as a Goblin King. More We can all be grown-ups and work jobs to provide for ourselves and our families. But there's nothing wrong with still keeping your inner child not just alive and well, but well fed. Sure, not everyone still gets that adults like to have their toys too (we just call them collectibles now), but it's become much more the norm. More Ladies and gentlemen, we’re living through a Golden Age of board gaming. We’ve taken a look at many of this year’s new releases and picked out some of our favorites which we happily recommend as gifts for the gamer in your life. (Or for yourself – no one's judging!) More Older family friends and relatives keep telling me at family gatherings they hear vinyl has been making a comeback. Well, as you likely know, it's been making that comeback for the last decade. This has opened up a new angle for record labels who specialize in reissues. More So 2016, you did it again. That moment of shock, that sudden realization that someone you have unquestioningly considered a part of your cultural tapestry has been cut away to leave you that little bit more fragile and exposed. Leonard Cohen-poet, muse, voice, conscience, inspiration-has left us for the last time. More Scotland's C Duncan (aka Chris Duncan) released his acclaimed debut album, Architect, last year via FatCat. It was nominated for the prestigious Mercury Prize and was a gorgeous collection with shades of Fleet Foxes and Grizzly Bear in its multi-layered harmonies. More There's a small moment in The Walking Dead's season one finale "TS-19," where Rick Grimes tells Dr. Edwin Jenner that he's "grateful" that he and his group have been allowed to enter the safety of the CDC. "The day will come when you won't be" is Jenner's grim reply. More Food, much like music, is a common and personal thread we all share. Our recurring guest feature I Can Cook, Too spotlights artist-submitted recipes and the stories behind them. This instalment features a recipe from Jamie Lidell. More We’ve reached the finish line. There are screenings beyond the final Friday, and I’m sure I’ve missed some excellent pieces of cinema – it’s unavoidable with a slate as varied and massive as TIFF’s. All in all, it was a fantastic festival. And even if my final day didn’t reach the heights of other days, there wasn’t a poor film in the bunch, which is encouraging. MoreThis disclosure relates to a method and apparatus for erecting a drilling rig and particularly, but not exclusively, to land rigs for drilling and servicing oil and gas wells. A variety of drilling rigs may be used in drilling and various wellbore operations; for example, and not by way of limitation, U.S. Pat. Nos. 3,340,938; 3,807,109; 3,922,825; 3,942,593; 4,269,395; 4,290,495; 4,368,602; 4,489,526; 4,569,168; 4,837,992; 6,634,436; 6,523,319, the entire contents of which are hereby incorporated by reference herein for all purposes. In many land drilling operations, land rigs may be delivered to a site, assembled and then disassembled. Land rig components may be easily transported and assembled. Costs associated with land rigs and associated equipment, can be calculated on a per hour or per day basis, and, therefore, efficient takedown, transport, and setup operations may be desirable. See example patent/applications U.S. Pat. No. 3,922,825; U.S. Pat. No. 3,942,593; U.S. Pat. No. 6,634,436; WO 2009/001133; WO 2009/106860; and WO 2009/106897, the entire contents of which are hereby incorporated by reference herein for all purposes.namespace Platform.VirtualFileSystem { public interface INodeServiceProvider { IService GetService(INode node, ServiceType serviceType); } }Get together with friends and family for some Minecraft-style tussling in this special seasonal battle map. The more the merrier! Guaranteed to be more fun than pretending you like the socks your uncle gave you. 1-4 player(s)Network Players 2-425KB Minimum Software subject to license (us.playstation.com/softwarelicense). Online features require an account and are subject to terms of service and applicable privacy policy (playstationnetwork.com/terms-of-service & playstationnetwork.com/privacy-policy). One time license fee entitles play on up to 3 PlayStation® Vita systems activated by this account.Tomb KV 40 at the Valley of the Kings was plundered several times and damaged by a fire. During recent excavations, archaeologists discovered mummified remains alongside fragments of coffins, cloth and pottery. Family members and children related to the pharaohs were likely buried here in the 14th century B.C. Archaeologists have discovered the final resting place of at least 50 royal Egyptians — including princes, princesses and infants — while excavating a trashed tomb at the Valley of the Kings. Hieratic inscriptions (a cursive form of hieroglyphs) revealed that most of the mummies in the tomb were related to two pharaohs, Thutmose IV and Amenhotep III, who ruled during the 14th century B.C. The dead included at least eight previously unknown royal daughters, four princes and some children, the archaeologists said. During Egypt's New Kingdom (1550-1070 B.C.), royals were buried at the Valley of the Kings, a site along the Nile, opposite modern-day Luxor, about 312 miles (500 kilometers) south of Cairo. King Tutankhamun's tomb is among the best preserved burials to have been discovered at the Valley of the Kings, and new tombs are still being discovered and studied at the site today. [See Images of the Mummies' Tomb and Egypt's Valley of the Kings] One of those newly studied tombs is KV 40. From the surface, the only hint of a burial chamber was a depression in the ground. Excavations revealed a 16-foot-deep (5 meters) shaft, a corridor and four rooms in shambles. The 3,300-year-old tomb was likely plundered for its gold and wood during antiquity, and later looted for any other valuable goods that could be sold. The archaeologists, who have been excavating in the region since 2009, found textiles, mummy bandages, linen cloths, bones and other scattered funerary artifacts in the tomb. These objects were covered with soot from a heavy fire, presumably set by grave robbers of the late 19th century. The adult mummies in KV 40 are largely fragmentary, likely torn apart by grave robbers, but infant corpses in the underground burial chamber remain intact, said researcher Susanne Bickel, of the University of Basel in Switzerland. And while most infants who died would have been buried in a simple fashion at the time, royal children
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recipients. In spite of some strong reasons behind this phenomenon, the exact mechanism of this unique tolerance remains unknown ([@B6]--[@B8]). Moreover, the underlying cascades and response elements have not yet been fully revealed. During different stages of liver allograft rejection or tolerance, huge numbers of immune cells, serum proteins, and molecules associated with immune responses will change in quantity and quality ([@B9]--[@B12]). Thus, high throughput proteomics technology designed to deal with this complexity was used to identify the large-scale molecular pathways and pathological mechanisms involved in the OLT. Previous study also demonstrated that several proteins, including haptoglobin, immunoglobulin, and the specific glycoproteins, should mediate the acquisition of self-tolerance ([@B13], [@B14]). However, other parts of the puzzle having a role in the immune responses should be implied since those proteins could not completely relieve the rejection after OLT. Numerous documents have implied that inflammatory responses should cause the induction and progression of hepatic injury after OLT ([@B15]--[@B17]). Many reports have indicated that highly reactive oxygen species (ROS) play a pivotal role in tissue damage of inflammatory organisms. Increased oxidative stress caused by acute inflammation would subsequently result in protein modifications and alteration of the amino acid sequence, leading to protein dysfunction and organ damage ([@B18], [@B19]). Next, impairment of the antioxidant proteins due to oxidative damage would cause the cells or tissues to be more vulnerable in the presence of inflammatory species such as cytokines and free radicals ([@B20]--[@B22]). Therefore, cytokine arrays were applied to monitor the recruitment of various cytokines/chemokines that reflect specific events in response to severe rejection after OLT. The functional "signature network" using MetaCore™ pathway analysis tools produces overall cellular mechanisms derived from differences in protein and cytokine levels. This method simultaneously delineates the signaling pathways in view of the architecture to represent biological functionality and the integration of molecular and clinical information ([@B23], [@B24]). In the current study, the comprehensive analysis of global changes in rat serum provides a feasible method for detecting possible mechanisms that play a critical role in providing immunological privilege in the OLT model. Our findings may provide important information for therapeutic designs after transplantation and enhance survival rate by predicting disease progression as well as treatment responses. Materials and methods {#s2} ===================== Orthotopic liver transplantation -------------------------------- Five DA (RT1^a^), five PVG (RT1^c^) and Five LEW (RT1^l^) inbred strains of male rats, weighing 200-250g, were housed at the SPF animal facility and allowed free access to water and standard rat chow. All the animal experiment and associated protocol were approved in compliance with the standards of Chang Gung University\'s Committee for the Use and Care of Animals. The Committee recognizes that the proposed animal experiment follows the guideline as shown in the "Guide for Laboratory Animal Facilities and Care" as promulgated by the Council of Agriculture. Orthotopic liver transplantation (OLT) was performed under ether anesthesia using Kamada\'s method with some modification ([@B11], [@B25]). DA livers were orthotopically transplanted into PVG recipients and the graft would overcome rejection without any immunosuppressive drugs ([@B26]). As a syngenic control, five DA donor livers were transplanted into five DA recipients. The blood and liver samples were obtained and stored in −80°C for further analysis. TUNEL assay ----------- Apoptosis was assessed by terminal deoxynucleotidyl transferase- mediated dUTP biotin nick end labeling (TUNEL) using ApopTag® Plus Peroxidase *in situ* Apoptosis Detection Kit (Millipore) according to the manufacturer\'s instructions. The slides was counterstained with eosin and mounted. The numbers of stained and unstained cells were then counted from randomly chosen fields per slide within a high-power field (×200 magnifications) under an Olympus BX50 microscope. Image-Pro plus 4.5 (Media Cybernetics) image analysis software was used to quantify image signals ([@B27]). Two-dimensional electrophoresis, image, and mass spectrometric analysis ----------------------------------------------------------------------- Aliquot serum (150 μg) samples were diluted in IPG sample buffer and rehydrated for 12 hr at 30 V. Isoelectric focusing (IEF) was conducted automatically with a total voltage of 90 kVhr. The second dimensional electrophoresis was carried out on 10 % acrylamide gels (Bio-Rad) at 40 mA. Proteins were visualized by silver staining and quantified using the Prodigy SameSpots software (Nonlinear Dynamics). Spots of interest were excised and in-gel digested with trypsin according to previously described procedures ([@B13], [@B27]). MS analysis was performed on an Ultraflex MALDI-TOF mass spectrometer (Bruker-Daltonik). Monoisotopic peptide masses were assigned and used for database searches with the Mascot search engine (<http://www.matrixscience.com>). Search parameters were set as follows: a maximum allowed peptide mass error of 50 ppm, and consideration of one incomplete cleavage per peptide ([@B28]). Rat cytokine protein array -------------------------- The spectrum of cytokines produced by apparently rejection and tolerance subjects was determined using an antibody-based protein microarray (RayBio Rat Cytokine Ab Array I and 1.1 Map, RayBiotech Inc.,) designed to detect 19 growth factors, cytokines and chemokines. Proteins were detected via an enhanced chemiluminescence procedure according to previously described procedures ([@B29]). By subtracting the background staining and normalizing to the positive controls on the same membrane, we obtained the relative protein concentrations. Biological network analysis using metacore™ ------------------------------------------- Applied MetaCore™ software (vers. 5.2 build 17389, GeneGo, St. Joseph, MI, USA) was applied to reveal associated ontological classes and relevant pathways which were represented among the proteins identified by the mass fingerprint and cytokine array ([@B28]). RNA isolation and northern blot ------------------------------- Total RNA was extracted from the rat liver using a TRIzol Reagent, and dissolved in diethylpyrocarbonate (DEPC)-treated water. Equal amount of total RNA was separated on denaturing formaldehyde agarose gels and blotted onto nylon membranes. Hybridization and detection were performed using detection kit (Thermo Fisher Scientific) according to the supplier\'s instruction. The β-actin transcript was used as an internal control to normalize the concentration of mRNA in each sample ([@B30], [@B31]). Transcript intensities were recorded as digitalized images using a high-resolution scanner and quantity by GeneTools Image Software (Syngene). 2-DE oxyblot ------------ Following isoelectric focusing, IPG strips were incubated in solution of 2N HCl with 10 mM 2,4-dinitrophenylhydrazine (DNPH) at 25°C for 20 min. After carbonyl derivatization step, strips were washed with 2 M Tris-base/30% glycerol for 15 min and then used for molecular weight dependent separation of proteins by SDS-PAGE, followed by protein blotting to a membrane. Next, this membrane was incubated overnight at 4°C with the anti-DNP (Sigma) in the TBST containing 5% non-fat milk. The blots were then incubated with goat anti-rabbit IgG/HRP conjugate for 2 hr at room temperature. Enhanced chemiluminescence (PerkinElmer) was used for detection ([@B24], [@B27]). Western blot analysis --------------------- Protein was separated with 10% SDS-PAGE and transferred to a PVDF membrane which was incubated with anti-ceruloplasmin, anti-PCNA, anti-caspase-3, anti-SOD-1, anti-catalase, anti-Nrf2, anti-HO-1 and anti-β-actin (Santa Cruz) overnight at 4°C. Blots were washed and incubated with HRP-labeled secondary antibody. After washing in TBST, enhanced chemiluminescence was used for protein detection. The band intensity was quantified using GeneTools Image Software (Syngene, UK), and β-actin was used as an internal control ([@B32]). The Western blot experiments were repeated in triplicate. Effects of ceruloplasmin silencing on cell survival under H~2~O~2~ treatment ---------------------------------------------------------------------------- HepG2 cells were plated onto 24-well plates (2 × 10^4^ cells/well), maintained in antibiotic-free medium for 6 hr, and transfected with a mixture containing Opti-MEM, 8 μL/well Lipofectamine 2000 (Invitrogen, San Diego, CA) and 0.5 μg/well a mixture of three ceruloplasmi siRNA. At 24 hr post-transfection, cells were pretreated with either 1 or 5 mM H~2~O~2~ dissolved in medium for another 24 hr. Then, the cells were harvested for MTT assays and Western blot analyses ([@B27], [@B32]). Results shown are the representative of three separate experiments. Statistical analysis -------------------- All values were presented as the mean ± standard deviation (SD). Statistical analysis of the mean values was carried out with the ANOVA using SPSS software (SPSS Inc., USA). Differences were considered as significant at ^\*^*p* \< 0.05. Results {#s3} ======= Validating the hepatic apoptosis via TUNEL histopathology --------------------------------------------------------- Histological investigation was performed to reveal *in situ* apoptotic conditions in the allogeneic transplant group. Based on previous findings, it was thought that severe AR, demonstrated by lymphocyte and eosinophils infiltration into the liver parenchyma around the portal fields and a great number of foci of necrotic hepatocytes, would occur within the liver lobules at POD14. On the
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a rather stereotyped dendritic branching pattern, despite a large variation in soma size.2.05.2010 bring on the spring and summer! right now i am missing the hot hot heat of summer and the florida sun. i want to be warm and and cozy to my bones, not chilled with frozen fingers all the time - in the car, at work, in the house. a few nights ago i fell asleep under our electric blanket set to high, then lowered to 7. it was like a cozy womb of heat. thankfully for anthony, there are separate controls for each side of the bed. 1 comment: I don't know about summer, but I'm ready for springtime all right. Bring on the crisp nights and comfortable days, open windows, grass-flowers and afternoon showers. I love reasons to wear winter layers, but the perpetual chilly damp is starting to get a little tiresome!MP's diet challenge focuses on world's poor A Christian MP from Glasgow is among those taking part in Tearfund's Mean Bean Challenge, to help highlight the plight of the world's poorest people ... Carol Monaghan, the MP for Glasgow North West, is committing to a diet of a handful of rice and beans to experience life like millions of the world’s poorest people and raise awareness of the work of Christian charity Tearfund. Ms Monaghan, who is the SNP’s education spokesperson, is taking part in Tearfund’s Mean Bean Challenge, living off a small amount of porridge, plain rice and plain beans a day, to highlight the plight of those in developing countries who have to survive on the same subsistence-level diet. The former physics teacher will join hundreds of people across the country doing the Mean Bean challenge to raise money for the international development agency. Ms Monaghan said: "I'm doing the Mean Bean challenge because I think it's a really tangible way of connecting with the harsh realities of poverty that millions of people face every day. I am sure living on so little food will be difficult for me, but many people have no choice. “It's a privilege to do this challenge to support Tearfund and the work they do in more than 50 countries around the world – including in East Africa where we are seeing famine taking hold." More than 800 people across the UK have already signed up to the gruelling week-long challenge, so far raising over £40,000 for the charity’s work in countries such as Ethiopia, Malawi, South Sudan and Kenya. The charity encourages people to sign up and support the Mean Bean Challenge. Tearfund’s International Director Myles Harrison, who is also doing the challenge, said: “What is happening to the millions of people facing famine is heartbreaking and it is unthinkable that in 2017 when we have more than enough food to feed everyone, millions of people around the world are still going to bed hungry. “Here in the UK we are often detached from the everyday difficulties families and whole communities are facing. Doing the Mean Bean challenge not only brings this home (I am wondering how I am going to get through the week and still be able to work!) but also helps to raise money for our projects which are providing life saving assistance in over 50 countries. Why not join in too and get your family and friends to sponsor you?” Donald Mavunduse, the charity’s Head of East and Southern Africa, said: “It is vital that we continue to fund the crucial work we are carrying out across Africa – pre-empting impending crises and dealing with those we’re seeing unfolding.” PHOTOS: Top: Christian SNP MP Carol Monagahan who is doing the Mean Bean challenge for Tearfund stands speaking in the House of Commons Above: Tearfund beneficiary Lyson who lives in the Dowa district, central Malawi whose family have received sustainable agricultural training, to grow enough food and earn a secure livelihood Get more inspiring reading Our print magazine for INSPIRE is currently on hold while we explore new funding options for a relaunch later this year. If you'd like to be kept up to date with developments, ready to order the new title once it's available, email [email protected] Wolf Conservation Center Review Now that the apple picking season and Halloween festivities are just about over, it’s time to start finding some other seasonal activities for our apple families. I don’t know about you, but I am no where near ready to head indoors. In our search for fall and winter outdoor activities, we visited the NY Wolf Conservation Center in South Salem to spend a morning with the wolves. That’s right, wolves! Different from their local relatives, the coyote, fox and dog, wolves are not native to NY so this was a special treat. The wolf center is currently home to 26 wolves including their famous four ambassador wolves- Atka, Alawa, Zephyr and Nikai. Many of their wolves are endangered so the Wolf Conservation Center is dedicated to promoting wolf conservation by teaching about wolves, their relationship to the environment, and the human role in protecting their future. The WCC accomplishes this mission through onsite and offsite education programs emphasizing wolf biology, the ecological benefits of wolves and other large predators, and the current status of wolf recovery in the United States. Unlike the ambassador wolves, the goal for their critically endangered wolves is to hopefully be reintroduced to the wild. So, why is the WCC a good place to visit now? The wolves love the cool weather and that’s when they can be found most active. To boot, the WCC has recently added more children’s programs to their calendar. My family and I attended the “Pack Chat for Kids” program. It was held at 11AM on a chilly Saturday morning. The wolf center sits perched high on a hill in a residential area of South Salem. The modest education building was the first stop where the learning began and we were happy to find it heated. Here our guide, Reagan, taught us all about the center and the wolves they are home to. This portion lasted about 30 minutes and was fairly interactive for the kids. My 3 year old probably didn’t get quite as much out of this as his 6 year old sister, but I was just pleased he sat for the duration. After the indoor portion we headed out to meet the wolves. My kids got a real kick out of how we were all instructed to howl to let the wolves know we were coming. What they liked better was when the wolves, led by their Alpha, howled back. In our first stop we met the majority of the ambassador wolves- the Canadian and Rocky Mountain Gray Wolves. Here the Alpha dynamic was demonstrated at a feeding session- a sight to behold. Next onto the Wild Arctic Gray Wolf Ambassador, and the ultimate Alpha of the center, “Atka.” And finally to the critically endangered Mexican Gray wolves and the Red Wolves. Each area we visited provided a place for sitting and viewing the wolves safely behind a high fence. Our guide told us more about each of the type of wolf and answered any questions we had. Lastly, we returned to the Education building to, of course, buy souvenirs. Normally, I am the mean Mom who runs from a souvenir shop. However, the souvenir shop was modest here and it’s one of the ways the Wolf Center receives funding. After meeting the wolves, they quickly make their way into your heart so it was an easy purchase to justify. The center is actually run largely by donation. In fact,the center is only 1% government funded. They have more volunteers than employees, they feed the wolves roadkill or food donated from the local Whole Foods, even their veterinary services are pro-bono. Yes, I was more than happy to help in any small way I can. So, is a visit to the Wolf Center for you? I think it’s for everybody. The Wolf Center has a variety of programs available for both adults and children throughout the week. See the full calendar here. It include everything from “Story time with the Wolves” for preschool aged children to the “Evening Howl for Adults” which includes wine and cheese! The center operates mainly on donations and your entrance supports their mission. So why not go for an educational outdoor family day that supports this worthy cause? This Apple Mom recommends the “”Pack Chat for Kids” for your elementary aged children. Younger children will benefit too, but should be able to sit for a good 30 minutes and understand that the wolves are not dogs. If you go, bring your camera and dress warmly in layers. In fact, one lucky Apple Moms HV Reader will win a Family Four Pack of ticket the the “Pack Chat for Kids” at a date of their choosing. Please refer to the calendar for available dates. Nicole S. Your email address will not be published. Required fields are marked * Comment Name* Email* Website Notify me of follow-up comments by email. Notify me of new posts by email. Subscribe to Blog via Email Enter your email address to subscribe to this blog and receive notifications of new posts by email. Join 5,102 other subscribers Email Address Affiliates Amazon Affiliate Disclosure Apple Moms HV LLC, is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to amazon.com.<?xml version="1.0"?> <document xmlns="http://maven.apache.org/X
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cranial direction, D4-L4 in caudal direction.](1743-0003-8-34-2){#F2} For fNIRS recording, one sensor was placed over the subject\'s left hemisphere over F3 according to the international 10-20 system \[[@B30]\]. With the compact sensor of 37.5 mm length and 25 mm width, we assumed to cover secondary motor areas, presumably including PMC and SMA. Cortical activation in these areas has been previously described during MI performance \[[@B31],[@B32]\]. The sensor was fixed on the subject\'s head using self-adhesive bandages (Derma Plast CoFix 40 mm, IVF Hartmann, Neuhausen, Switzerland). 2.4 EMG measurements -------------------- Surface electromyogram (EMG) was monitored bilaterally in combination with fNIRS in all subjects to confirm the absence of muscle activity during the MI tasks. EMG was obtained using a customisable asymmetrical dual channel digital EMG unit (NeuroTrac™ ETS, Verity Medical Ltd., Romsey, Hampshire, United Kingdom) that detects electrical activity from 0.2 μV up to 2000 μV. One pair of electrodes was placed over musculus extensor digitorum muscles to measure (1) the activity during the MI tasks, (2) the level of muscle activity during the rest phases and (3) the timing and frequency of the finger-tapping during the ME control measurements. After each session, EMG data were graphically displayed and visually reviewed for task-unrelated movements using the automated EMG software application (Verity Medical Ltd., NeuroTrac™EMG Software). In all recorded subjects, EMG graphics showed that subjects performed the right hand button presses during the ME control measurements with a suitable timing and frequency; activity was lower during the rest phase compared to the active stimulation phases; there was no activity recorded in the left (unused) hand during both ME controls (\< 20 μV). During the MI tasks, EMG of both forearms showed a constant electrical activity below \< 20 μV. In two subjects the electrical activity of the right forearm seemed to be higher and more variable in the MI-complex task than in MI-simple, but still \< 20 μV. 3 Data analysis =============== 3.1 Data pre-processing ----------------------- By measuring intensity of NIR light after its transmission through tissue, it is possible to determine oxygenation changes over time of oxy-hemoglobin (O~2~Hb) and deoxy-hemoglobin (HHb), which represent the dominant light absorbers for living tissue in the NIR spectral band. By applying the modified Beer-Lambert law (MBLL), the concentration for O~2~Hb and HHb (\[O~2~Hb\], \[HHb\]) were computed from the measured absorption changes \[[@B33],[@B34]\]. A program for MATLAB^®^(Version 2008a) was written and applied to pre-process the raw light intensity values and to compute \[O~2~Hb\] and \[HHb\] changes. The measurement files that were acquired during the fNIRS experiment containing the intensity signals of the NIR light, sampled at 100 Hz for all combinations of light-sources, wavelengths and detectors, as well as the intensity of the ambient light. The program subtracts the ambient light intensities from the fNIRS measurement values before low-pass filtering (7th order Chebyshew with 20 dB attenuation at 5 Hz) and decimates the signals to a sampling rate of 10 Hz. Consecutively, the MBLL is used to compute the changes of \[O~2~Hb\] and \[HHb\] applying differential path lengths factors (DPF) of 6.75 for the 760 nm and 6.50 for the 870 nm light-sources \[[@B35]\]. The linear signal drift is then subtracted from the resulting \[O~2~Hb\] and \[HHb\] signals. Source-detector combinations (channels) that did not show significant oxygenation changes in individual subjects were excluded from further analysis, since it was assumed that those channels did not cover the activated cerebral region at all. For this reason the fourth channel was excluded from analysis as its more lateral location was prone to high artifacts and had a very low signal to noise ratio. Further, subjects that did not show significant oxygenation changes (p \> 0.05) in all channels in the ME control measurements and the MI tasks were excluded from analysis. Consecutively, dependent variables for further statistical analysis were derived from the non-excluded \[O~2~Hb\] and \[HHb\] datasets. Specifically, the mean of the stimulation phases (\[HHb\]~stim~, \[O~2~Hb\]~stim~,) and the mean of the rest phases (\[HHb\]~rest~, \[O~2~Hb\]~rest~, baselines) were considered, calculated for each trial and channel per subject. The statistical significance of the intra-condition differences between (\[HHb\]~rest~, \[O~2~Hb\]~rest~) and (\[HHb\]~stim~, \[O~2~Hb\]~stim~), later referred to as Δ\[HHb\] and Δ\[O~2~Hb\], was analyzed over channels 1-3 for each condition, each subject in the control ME tasks and the MI conditions using the paired t-test (CI 95%, alpha level p ≤ 0.005, power p = 0.764). The signal-to-noise ratio (SNR, defined as the ratio of the mean signal to its standard deviation) was calculated to evaluate the signal strength within each channel. 3.2 Single-trial classification of MI signals --------------------------------------------- Single-trial classification was performed of the hemodynamic signals obtained after processing using SPSS (Version 16.0). Previous studies have either classified light intensity directly \[[@B6]\] or converted the signals to haemoglobin concentrations \[[@B4]\] prior to classification. Since it has not been shown that one method is more discriminating than the other, we classified the processed optical signals. The goal of the classification was to discriminate the two MI tasks based on single-trial signals. In particular, we aimed to classify Δ\[O~2~Hb\] signals derived from the difference between the baselines phases (20 s) and the stimulation phases (15 s) of each single-trial into one of the two tasks (MI-simple or MI-complex). The classification was based on the definition of a best-performing combination for each subject consisting of: 1) a specific channel, 2) a specific analysis time interval within the stimulation phase and 3) a set of up to four signal features. 1\. Channels: each of the channels 1-3 were tested separately for each subject and the best-performing channel was selected. 2\. Analysis time intervals: each time interval within the stimulation phase (0-15 s in Figure [1](#F1){ref-type="fig"}) was defined by a start time and an end time. Start times ranged from 1 - 11 s in 1 s increments, while end times spanned from 5 - 15 s, also in 1 s increments. All possible combinations of start and end times were considered as valid time intervals for classification. These start and end times were considered according to the typical time course of the hemodynamic response delay after stimulation onset \[[@B36],[@B37]\]. 3\. Features: the following four features were selected from those previously published and tested by \[[@B7]\]. All features were calculated for each subject (N = 12 subjects) and each trial (N = 12 trials): ○ Mean: average signal amplitude. ○ Variance: measure of signal spread. ○ Skewness: measure of the asymmetry of signal values around its mean relative to a normal distribution. ○ Kurtosis: measure of the degree of peakedness of a distribution of signal values relative to a normal distribution. Using Fisher\'s linear discriminant analysis (FLDA) all possible classification combinations were tested for each subject. Classification accuracy was evaluated using cross validation. Due to the relatively small size of the feature space, an exhaustive search was performed for each subject, and the best-performing combination was reported. Two-tailed Pearson\'s correlation coefficients (*r*) with p-value (significance level *p*≤ 0.05) were calculated to evaluate correlations between the mean values of the four features and the classification accuracy within the selected subjects. 4 Results ========= 4.1 Control ME measurements --------------------------- We first analysed the control ME measurements to confirm our assumption that we were indeed recording from motor-related cortical areas, i.e. presumably secondary motor areas relevant for MI performance. Two subjects were excluded at this stage as their data did not show significant Δ\[O~2~Hb\] increases. In all remaining subjects (N = 12), the control ME measurements elicited significant intra-control differences between baselines and stimulation phases. On the overall-subject-level significant larger averaged amplitudes were observed during ME-complex (Δ\[O~2~Hb\] 0.453 ± 0.098 μmol/l; Δ\[HHb\] -0.0675 ± 0.021 μmol/l) as compared to ME-simple (Δ\[O~2~Hb\] 0.189 ± 0.055 μmol/l; Δ\[HHb\] -0.032 ± 0.078 μmol/l) (inter-task paired t-test overall channels: Δ\[O~2~Hb\] *p*= 0.001, Δ\[HHb\] *p*= 0.012). The keystroke data were used to confirm our hypothesis that the complex task was indeed more difficult than the simple task. The errors
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for percentage positive MUC1 cells was set using the appropriate isotype control; **(C)** Proteins over-expressed in KCM versus KCKO-tumor cell lysates from tumor-bearing mice determined by proteomics analyses (Data expressed in fold changes); **(D)** PGE~2~ concentrations in conditioned media of KCM and KCKO cells measured by ELISA; **(E,F)** PGEM (13,14-dihydro-15-keto PGA~2~) concentrations quantified by ELISA in serum and tumor lysate from tumor-bearing mice (*n* = 4). Mean and standard error plotted. \**p* \< 0.05, \*\**p* \< 0.01, and \*\*\**p* \< 0.001 for statistically significant differences from control levels unless indicated by the line above the bars.](fimmu-05-00067-g005){#F5} Further, the concentration of PGE~2~, the major byproduct of the COX enzyme activities was significantly higher in the KCM TCCM compared to the KCKO and 3T12 TCCM (Figure [5](#F5){ref-type="fig"}D). Similarly, levels of PGE metabolite (PGEM; 13,14-dihydro-15-keto PGA~2~) were significantly higher in the tumors and serum of mice bearing the KCM-tumor compared to KCKO and 3T12 tumors (Figures [5](#F5){ref-type="fig"}E,F). Inhibition of COX-2 reverses MUC1 driven effects on MDSC maturation and function {#S3-21} -------------------------------------------------------------------------------- To determine if indeed MUC1 driven effects on MDSC maturation and suppression were mediated by COX/PGE~2~, we treated KCM cells with the selective inhibitor of COX-2 (Celecoxib). KCM cells were treated with 50 μM of Celecoxib for 48 h and TCCM collected. Treatment with Celecoxib significantly reduced the expression of COX-2 in KCM cells as determined by western blot analyses (Figure [6](#F6){ref-type="fig"}A). When BM cells were cultured with TCCM from KCKO, KCM, and Celecoxib-treated KCM cells, we observed no differences in the numbers of total Gr1^+^CD11b^+^ cells (Figure [6](#F6){ref-type="fig"}B). However, a significant increase was observed in the expression of the maturation markers (CD11c and CD115) in MDSCs derived using TCCM from Celecoxib-treated KCM cells (Figures [6](#F6){ref-type="fig"}C,D). In addition, a significant decrease in the percentages of iNOS^+^ and Arg-1^+^ cells was observed in MDSCs derived with TCCM from Celecoxib-treated KCM cells, approaching the levels observed with KCKO TCCM (Figures [6](#F6){ref-type="fig"}E,F). These findings strongly indicate that inhibiting the COX-2 pathway enables the immature KCM-induced MDSCs to undergo maturation and in turn lose their suppressive phenotype. ![**COX-2 inhibitor Celecoxib reverses the suppressive phenotype of MDSCs**. BM cells (*n* = 4) were cultured with 30% v/v TCCM from KCKO, KCM, and celecoxib-treated KCM cells (with 50 μM Celecoxib). Cells were stained with anti-Gr1, anti-CD11b, anti-CD11c, anti-CD115, anti-iNOS, and anti-Arg-1 antibodies. **(A)** Western blot analysis and quantitative densitometry of the protein expression of COX-2 gene on whole cell lysates from KCM and celecoxib-treated KCM cells. COX-2 protein expression was normalized for β-actin protein expression. Western blotting for COX-2 and β-actin protein expression was carried out 3 times; **(B)** Percentage of Gr1^+^CD11b^+^ MDSC population; **(C,D)** Expression of CD11c and CD115 expression on Gr1^+^CD11b^+^ cells; **(E,F)** Percentage of iNOS^+^ and Arg-1^+^ cells on Gr1^+^CD11b^+^ gated cells. Percentages are not absolute numbers. Mean and standard error are shown. \**p* \< 0.05, \*\**p* \< 0.01, and \*\*\**p* \< 0.001 for statistically significant differences from KCKO levels unless indicated by the line above the bars.](fimmu-05-00067-g006){#F6} Discussion {#S4} ========== Patients with pancreatic cancer display high levels of circulating tumor MUC1 (CA19-9) that correlate with poor prognosis and disease recurrence ([@B36]). In addition, these patients exhibit significant immune dysfunction characterized by increased levels of immune suppressor cells including T~regs~ and MDSCs ([@B37], [@B38]). Although, tumor-associated MUC1 has been reported to be immunosuppressive ([@B39], [@B40]), its role in MDSC generation and function in pancreatic cancer has never been explored. We recently reported that tumors from PDA mice that over express human MUC1 have elevated levels of MDSCs and favor a highly immune suppressive and pro-inflammatory microenvironment ([@B13]). In this study, we report that there was a significant increase in total MDSC numbers in the spleen of KCM versus KCKO-tumor-bearing mice but no difference in the BM (Figure [3](#F3){ref-type="fig"}). This implies that KCM-tumor may have a profound effect on the recruitment of MDSCs to the lymphoid organs but not on its differentiation in the BM. Further, we show *in vitro* that TCCM from KCM cells promote the expansion of a monocytic MDSC subset, that are immature and more suppressive than MDSCs derived using TCCM from KCKO cells (Figure [1](#F1){ref-type="fig"}). Interestingly, when the individual MDSC subsets were further analyzed for presence of maturation and suppressive markers, lower levels of CD11c and CD115 was observed in both the monocytic and granulocytic MDSC subsets (Figures S1C--F in Supplementary Material). However, an increase in iNOS^+^ cells was predominantly in the monocytic subset while an increase in Arg-1^+^ cells was predominantly in the granulocytic subset (Figures S1G--J in Supplementary Material). The observations that the suppressive activity of MDSCs is primarily conferred by the monocytic subset and that as MDSCs mature, they lose their suppressive capability is supported by several other published studies ([@B24], [@B32], [@B33]). Our findings indicate that MUC1 expression in the tumor plays a key role in maintaining the MDSCs in an immature and highly suppressive state and may partially account for the metastatic nature of MUC1^+^ PDA tumors. Indeed, KCM-tumors grow significantly larger than KCKO-tumors in immune competent syngeneic mice ([@B9], [@B13]) (Figure [3](#F3){ref-type="fig"}A). Both COX-2 and IL-10 are implicated in MDSC expansion and activation ([@B15]). It is well established that there is a positive feedback between PGE~2~ and COX-2 that redirects the differentiation of human dendritic cells toward stable MDSCs ([@B41], [@B42]). In line with that, our data demonstrates that KCM cells express high levels of COX-2 and IL-10 (Figure [5](#F5){ref-type="fig"}A) and stimulates the generation of highly suppressive and immature MDSCs, thus highlighting the clinical significance of the study. Furthermore, compared to KCKO, KCM-tumors exhibit a fourfold increase in COX-1, sevenfold increase in PGE synthase-2, and threefold increase in PGE synthase-3 levels (Figure [5](#F5){ref-type="fig"}C). Thus, we postulate that KCM cells may activate the COX-pathway which in turn contributes to the generation of suppressive MDSCs. These increases in the COX-pathway enzymes were correlated with elevated levels of PGE~2~ in the TCCM from KCM-tumor cells and PGEM (PGE~2~ metabolite) in the tumor and serum of KCM-tumor-bearing mice (Figures [5](#F5){ref-type="fig"}D--F). Thus, when TCCM from celecoxib-treated KCM cells was used, the MDSCs generated expressed low suppressive factors and high maturation markers similar to the phenotype generated with KCKO TCCM (Figures [6](#F6){ref-type="fig"}C--F). The PGE synthases along with COX-1 and COX-2 are essential for the synthesis of prostaglandins including PGE~2~ from Prostaglandin H~2~ and are being explored as novel therapeutic targets for treatment of various inflammatory diseases and cancer ([@B43], [@B44]). The central role of COX-2-PGE~2~ feedback in the induction and persistence of MDSCs highlights the potential for its manipulation to enhance or suppress immune responses in cancer ([@B41], [@B42]). Taken together, the data suggests that tumor-associated MUC1 in KCM cells hinders myeloid maturation and drives the generation and maintenance of an immature, suppressive MDSC population partly via activation of the COX-pathway. \[*Of note is that the two cell lines KCM and KCKO are derived from the same triple transgenic
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this->CoreDefinitionMap = NULL; this->CustomDefinitionMap = 0; this->InvalidCoreIterator = true; this->InvalidCustomIterator = true; } ~vtkInternalDefinitionIterator() override {} //------------------------------------------------------------------------- void Reset() { this->Initialized = true; this->InvalidCoreIterator = true; this->InvalidCustomIterator = true; if (this->GroupNames.size() == 0) { // Look for all name available if (this->CoreDefinitionMap) { StrToStrToXmlMap::iterator it = this->CoreDefinitionMap->begin(); while (it != this->CoreDefinitionMap->end()) { this->AddTraversalGroupName(it->first.c_str()); it++; } } if (this->CustomDefinitionMap) { StrToStrToXmlMap::iterator it = this->CustomDefinitionMap->begin(); while (it != this->CustomDefinitionMap->end()) { this->AddTraversalGroupName(it->first.c_str()); it++; } } if (this->GroupNames.size() == 0) { // TODO vtkErrorMacro("No definition available for that iterator."); return; } this->Initialized = false; this->Reset(); } else { this->GroupNameIterator = this->GroupNames.begin(); } } //------------------------------------------------------------------------- bool IsDoneWithGroupTraversal() { return this->GroupNames.size() == 0 || this->GroupNameIterator == this->GroupNames.end(); } //------------------------------------------------------------------------- bool IsDoneWithCoreTraversal() { if (this->CoreDefinitionMap && !this->InvalidCoreIterator) { return this->CoreProxyIterator == this->CoreProxyIteratorEnd; } return true; } //------------------------------------------------------------------------- bool IsDoneWithCustomTraversal() { if (this->CustomDefinitionMap && !this->InvalidCustomIterator) { return this->CustomProxyIterator == this->CustomProxyIteratorEnd; } return true; } //------------------------------------------------------------------------- void NextGroup() { this->CurrentGroupName = *GroupNameIterator; this->GroupNameIterator++; if (this->CoreDefinitionMap) { this->CoreProxyIterator = (*this->CoreDefinitionMap)[this->CurrentGroupName].begin(); this->CoreProxyIteratorEnd = (*this->CoreDefinitionMap)[this->CurrentGroupName].end(); this->InvalidCoreIterator = false; } if (this->CustomDefinitionMap) { this->CustomProxyIterator = (*this->CustomDefinitionMap)[this->CurrentGroupName].begin(); this->CustomProxyIteratorEnd = (*this->CustomDefinitionMap)[this->CurrentGroupName].end(); this->InvalidCustomIterator = false; } } //------------------------------------------------------------------------- void NextCoreDefinition() { this->CoreProxyIterator++; } //------------------------------------------------------------------------- void NextCustomDefinition() { this->CustomProxyIterator++; } private: bool Initialized; std::string CurrentGroupName; StrToXmlMap::iterator CoreProxyIterator; StrToXmlMap::iterator CoreProxyIteratorEnd; StrToXmlMap::iterator CustomProxyIterator; StrToXmlMap::iterator CustomProxyIteratorEnd; StrToStrToXmlMap* CoreDefinitionMap; StrToStrToXmlMap* CustomDefinitionMap; std::set<std::string> GroupNames; std::set<std::string>::iterator GroupNameIterator; bool InvalidCoreIterator; bool InvalidCustomIterator; }; //****************************************************************************/ vtkStandardNewMacro(vtkSIProxyDefinitionManager) vtkStandardNewMacro(vtkInternalDefinitionIterator) //--------------------------------------------------------------------------- vtkSIProxyDefinitionManager::vtkSIProxyDefinitionManager() { this->Internals = new vtkInternals; this->InternalsFlatten = new vtkInternals; vtkPVPluginTracker* tracker = vtkPVPluginTracker::GetInstance(); // Load the core xmls. // These are loaded from the vtkPVInitializerPlugin plugin. for (unsigned int cc = 0; cc < tracker->GetNumberOfPlugins(); cc++) { vtkPVPlugin* plugin = tracker->GetPlugin(cc); if (plugin && strcmp(plugin->GetPluginName(), "vtkPVInitializerPlugin") == 0) { this->HandlePlugin(plugin); break; } } // Now, process any other loaded plugins. This has to happen after loading the // core xmls (BUG #13488). for (unsigned int cc = 0; cc < tracker->GetNumberOfPlugins(); cc++) { vtkPVPlugin* plugin = tracker->GetPlugin(cc); if (plugin && strcmp(plugin->GetPluginName(), "vtkPVInitializerPlugin") == 0) { continue; } this->HandlePlugin(plugin); } // Register with the plugin tracker, so that when new plugins are loaded, // we parse the XML if provided and automatically add it to the proxy // definitions. tracker->AddObserver( vtkCommand::RegisterEvent, this, &vtkSIProxyDefinitionManager::OnPluginLoaded); } //--------------------------------------------------------------------------- vtkSIProxyDefinitionManager::~vtkSIProxyDefinitionManager() { delete this->Internals; delete this->InternalsFlatten; } //---------------------------------------------------------------------------- void vtkSIProxyDefinitionManager::InvokeCustomDefitionsUpdated() { this->InvokeEvent(vtkSIProxyDefinitionManager::CompoundProxyDefinitionsUpdated); this->InvokeEvent(vtkSIProxyDefinitionManager::ProxyDefinitionsUpdated); } //---------------------------------------------------------------------------- void vtkSIProxyDefinitionManager::AddElement( const char* groupName, const char* proxyName, vtkPVXMLElement* element) { bool updated = false; if (element->GetName() && strcmp(element->GetName(), "Extension") == 0) { // This is an extension for an existing definition. vtkPVXMLElement* coreElem = this->Internals->GetProxyElement(this->Internals->CoreDefinitions, groupName, proxyName); if (coreElem) { // We found it, so we can extend it for (unsigned int cc = 0; cc < element->GetNumberOfNestedElements(); cc++) { coreElem->AddNestedElement(element->GetNestedElement(cc)); } updated = true; } else { vtkWarningMacro("Extension for (" << groupName << ", " << proxyName << ") ignored since could not find core definition."); } } else { // Just referenced it this->Internals->CoreDefinitions[groupName][proxyName] = element; updated = true; } if (updated) { // Let the world know that a core-definition was registered i.e. added or // modified. RegisteredDefinitionInformation info(groupName, proxyName, false); this->InvokeEvent(vtkCommand::RegisterEvent, &info); } } //--------------------------------------------------------------------------- vtkPVXMLElement* vtkSIProxyDefinitionManager::GetProxyDefinition( const char* groupName, const char* proxyName, const bool throwError) { vtkPVXMLElement* element = this->Internals->GetProxyElement(groupName, proxyName); if (!throwError || element) { return element; } else { vtkErrorMacro(<< "No proxy that matches: group=" << groupName << " and proxy=" << proxyName << " were found."); } return 0; } //--------------------------------------------------------------------------- void vtkSIProxyDefinitionManager::ClearCustomProxyDefinitions() { this->Internals->CustomsDefinitions.clear(); this->InvokeCustomDefitionsUpdated(); } //--------------------------------------------------------------------------- void vtkSIProxyDefinitionManager::RemoveCustomProxyDefinition( const char* groupName, const char* proxyName) { if (this->Internals->HasCustomDefinition(groupName, proxyName)) { this->Internals->CustomsDefinitions[groupName].erase(proxyName); // Let the world know that definitions may have changed. RegisteredDefinitionInformation info(groupName, proxyName, true); this
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proceedings were commenced by the parties; petitioner sought to take the deposition of one Dr. Raymond R. Killinger, Jr., the respondent's treating psychiatrist from June 17, 1967 to April 5, 1969. Petitioner asserts that Dr. Killinger, at the instruction of respondent's attorney, refused to allow counsel for petitioner to inspect or to have read into the deposition his records concerning his treatment of the respondent nor was Dr. Killinger permitted to answer any questions concerning respondent's mental condition on the date of the accident. Petitioner filed a motion to compel discovery and respondent filed a motion for *189 protective order limiting the scope of examination. The trial court entered an order pursuant to F.S. section 90.242, F.S.A., concluding in part as follows: "* * * Dr. Killinger shall answer all questions which are relevant to the subject matter of this action; if the Plaintiff objects on the grounds that the material sought after, which may be either in the doctor's records or personal knowledge, is irrelevant and privileged, Dr. Killinger shall state (1) the general nature of the subject matter involved (either in his records or personal knowledge) and (2) why, in his opinion, the subject matter sought after is not relevant, in order to assist the Court in later rulings on certified questions. Further, the Defendant shall be entitled to a personal examination of only those parts of Dr. Killinger's records concerning his treatment of the Plaintiff which are relevant to the subject matter of this action; Dr. Killinger shall not be required to read nor may the Defendant examine those parts of his records objected to by the Plaintiff and, in such event, Dr. Killinger shall state the general nature of such records and why it is not relevant, as set forth above." (Emphasis supplied.) Petitioner suggests that the wording of the aforementioned order permits plaintiff's attorney and treating psychiatrist to determine a legal question, i.e. relevancy, without the court or counsel for defendant ever having had the opportunity to examine the actual records concerning the plaintiff's treatment. Petitioner seeks review of this order asserting that petitioner will suffer irreparable harm by not being given the benefit of examining the actual records and being heard as to their relevancy and also by not being given the benefit of the court's ruling on the legal question of the relevancy of the actual records as opposed to only Dr. Killinger's statement of the general nature of the subject matter involved. The decision of the Florida Supreme Court in Brooks v. Owens, Fla. 1957, 97 So.2d 693, discusses the circumstances under which interlocutory proceedings at law are reviewable by certiorari, as follows: "This court will review an interlocutory order in law only under exceptional circumstances. Where it clearly appears that there is no full, adequate and complete remedy by appeal after final judgment available to the petitioner, this court will consider granting the writ, as where the lower court acts without and in excess of its jurisdiction, or the order does not conform to essential requirements of law and may cause material injury throughout subsequent proceedings for which the remedy by appeal will be inadequate. * * *" We have carefully reviewed the order of the trial court in light of the Brooks decision and are of the opinion that the petitioner has failed to demonstrate that the order complained of does not conform to the essential requirements of law. The order of the trial court was entered pursuant to F.S. section 90.242, F.S.A., which section creates a psychiatrist-patient privilege, and provides, in part, as follows: "90.242 Psychiatrists as witnesses; non-disclosure of communications with patient "(1) * * * "(2) Except as hereinafter provided, in civil and criminal cases, in proceedings preliminary hereto, and in legislative and administrative proceedings, a patient or his authorized representative, has a privilege to refuse to disclose, and to prevent a witness from disclosing, communications between patient and psychiatrist, or between members of the patient's family and the psychiatrist, or records, relating to diagnosis or treatment of the patient's mental condition. *190 "(3) There shall be no privilege for any relevant communications under this section: (a) * * * (b) In a criminal or civil proceeding in which the patient introduces his mental condition as an element of his claim or defense, or, after the patient's death, when said condition is introduced by any party claiming or defending through or as a beneficiary of the patient. Laws 1965, c. 65-404, § 1, eff. June 25, 1965." The trial judge's order reflects a great concern for the rights of the respective parties and carefully endeavors to maintain the proper balance between facilitating the ascertainment of truth in connection with legal proceedings and avoiding unwarranted intrusions into the confidences of the psychiatrist-patient relationship. We do not read the trial court's order (as petitioner suggests) as delegating to the psychiatrist or respondent's attorney the judicial determination of what constitutes "relevant communications". On the contrary, this suggestion is clearly negated by the language of the order indicating "later rulings on certified questions" in the event that respondent objects to certain inquiries or inspections of matters not relevant to the proceedings. To assist the court in making these "later rulings" the court has required the psychiatrist to state "why, in his opinion, the subject matter sought after is not relevant". We do not deem this requirement to be unreasonable nor do we construe this language as delegating the determination of relevancy to the psychiatrist as this determination is solely a judicial question. Moreover, since the entry of the order under appeal, no questions have been propounded and we can neither speculate as to what questions would be relevant nor assume that the trial court does not intend to pass upon the question of relevancy. The procedural and substantive determination of relevancy would be guided by the customary rules of practice applicable to discovery except as hereinafter noted. The construction and interpretation of the psychiatrist-patient privilege under Section 90.242 is a matter of first impression in this state and for that reason we would make the following observations for the benefit of the parties and the trial court. One of the most exhaustive treatments dealing with the scope and extent of this privilege appears in the recent decision of the Supreme Court of California in In re Lifschutz, 1970, 2 Cal.3d 415, 85 Cal. Rptr. 829, 467 P.2d 557. The problem has also been discussed in a very recent annotation appearing in 21 A.L.R.3d 912-925. See also City of Portsmouth v. Cilumbrello, 1963, 204 Va. 11, 129 S.E.2d 31. The Supreme Court of California reflects upon the very delicate and sensitive relationship between the psychiatrist and his patient: "`The psychiatric patient confides more utterly than anyone else in the world. He exposes to the therapist not only what his words directly express; he lays bare his entire self, his dreams, his fantasies, his sins, and his shame. Most patients who undergo psychotherapy know that this is what will be expected of them, and that they cannot get help except on that condition. * * * It would be too much to expect them to do so if they knew that all they say — and all that the psychiatrist learns from what they say — may be revealed to the whole world from a witness stand.'" (85 Cal. Rptr. p. 839, 467 P.2d p. 567) The California court also recognizes that a patient's privacy may be the proper subject of inquiry: "First, the courts have noted that the patient, in raising the issue of a specific ailment or condition in litigation, in effect dispenses with the confidentiality of that ailment and may no longer justifiably seek protection from the humiliation of its exposure. Second, the exception represents a judgment that, in all fairness, *191 a patient should not be permitted to establish a claim while simultaneously foreclosing inquiry into relevant matters. As we explained in City and County of San Francisco v. Superior Court, supra, 37 Cal.2d 227, 232, 231 P.2d 26, 28 (the Catton case), `The whole purpose of the [physician-patient] privilege is to preclude the humiliation of the patient that might follow disclosure of his ailments. When the patient himself discloses those ailments by bringing an action in which they are in issue, there is no longer any reason for the privilege. The patient-litigant exception precludes one who has placed in issue his physical condition from invoking the privilege on the ground that disclosure of his condition would cause him humiliation. He cannot have his cake and eat it too.'" (85 Cal. Rptr. p. 841, 467 P.2d p. 569) However, this does not mean whenever a patient institutes a claim for any physical or mental suffering he invites an automatic inquiry and intrusion into all past communications which may have transpired with a psychiatrist. A balancing of the rights of the respective parties must occur in light of the privilege and the nature of the judicial proceedings. As we observed earlier the trial court must strive to maintain the proper balance between "facilitating the ascertainment of truth in connection with legal proceedings and avoiding unwarranted intrusions into the confidences of the psychiatrist-patient relationship." The key to unlocking the door to discovery and permitting this balanced entry is found in the two-word admonition in subsection (3) of Section 90.242, supra, i.e. "relevant communications". The determination of what constitutes relevant communications is by no means an easy task in this psychiatrist-patient area. The court in Lifschutz gives us some insight into this thorny question of "relevancy" as follows: "The patient-litigant exception allows only a limited inquiry into the confidences of the psycho-therapist-patient relationship, compelling disclosure
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Personally, I am not a fan of the artist's drawing style, but his work is consistent throughout the chapters. Also the design of the protagonist makes her "ordeal" look even more painful.The present invention relates to the new and distinct Red Hot Poker, Kniphofia ‘Poker Face’ hybridized under the direction of the inventor at a wholesale perennial nursery in Zeeland, Mich., USA. The new plant was the result of a single seedling selection from a cross of ‘Echo Rojo’ U.S. Plant Pat. No. 22,791 as the female parent as the female parent and ‘Papaya Popsicle’ U.S. Plant Pat. No. 22,915 as the male parent as the male parent in 2012. The plant passed initial evaluation in the summer of 2014 and was subsequently given the breeder code KNIF-12-5. Kniphofia ‘Poker Face’ has been successfully asexually propagated by garden rhizome division method since 2014 at the same wholesale perennial nursery in Zeeland, Mich. and subsequently by shoot tip tissue culture, and both methods have been found to be stable and produce identical plants that maintain the unique characteristics of the original plant through multiple generations. No plants of Kniphofia ‘Poker Face’ have been sold, in this country or anywhere in the world, with this name or any other name, prior to the filing of this application, nor has any disclosure of the new plant been made prior to the filing of this application except that which was disclosed within one year of the filing of this application and was either derived directly or indirectly from the inventor.I have problems letting go. Need an example? Despite hating it since, say, its second season, I still watched all of Entourage. I’m not proud of this. I feel like I should be admitting it at some sort of anonymous meeting. But perhaps it’s slightly defensible, though: everyone else was hate-watching it too, after all. Weezer may be a better example, and not just because they’re the focus of this post. 1994’s Weezer and 1997’s Pinkerton were important and transformative albums for me. I love them to this day. Unlike many, though, I haven’t been able to walk away from the band as they released bad album after bad album. I didn’t disagree with the general consensus (even if some reviews were ridiculously harsh) but I always found something to grasp onto: a song, a demo, a performance. I didn’t love Weezer, but I loved the idea that if someone could lose it as quickly as Rivers Cuomo did, perhaps one could get it back just as quickly some day. Obviously, that hasn’t quite happened. Sure, there have been some bright spots — the Home Recordings series is worth your time, front to back, embarrassments (“This Is The Way”) included — but everything is fragmented. Pinkertoncame out more than 15 years ago (ugh), and there’s not that much to show for it. And yet, I’ve heard it all. I’ve heard everything the band has released officially. I’ve heard every demo that Rivers Cuomo has leaked to the web. Hell, I once had the chance to hear a rare song and leak it. If there’s a sad way to sum up my life, it’s this: I’m a Weezer scholar. I thought I might put this “expertise” to some good use by building a fake album for your enjoyment. You can find it below, courtesy of my favorite streaming service Rdio. Like Weezer’s best albums, it’s ten tracks. I limited myself to original songs from 2001’s Weezer onward. I also picked songs that were released for purchase on an album, including “deluxe” editions. I did this for two reasons: Weezer is terrible at sequencing albums (four of these tracks come from deluxe editions, and one other comes from Death to False Metal, an album composed of album cast-offs) and I doubt anyone’s too interested in hearing scratchy and hastily arranged demos based on a nugget of a good idea. Finally, I omitted singles, because you’ve likely heard them, and likely hate them (“Photograph”would have been the only contender.) I hope you enjoy it. I listen to Weezer so you don’t have to … minus today. TEXAS COURT OF APPEALS, THIRD DISTRICT, AT AUSTIN NO. 03-00-00326-CR Abraham Garcia, Appellant v. The State of Texas, Appellee FROM THE DISTRICT COURT OF BELL COUNTY, 27TH JUDICIAL DISTRICT NO. 50,642, HONORABLE MARTHA J. TRUDO, JUDGE PRESIDING Appellant Abraham Garcia was released on bond pending trial on an indictment accusing him of burglary of a habitation. He subsequently failed to appear in accordance with the conditions of that bond. Based on this evidence, a jury found appellant guilty of failing to appear and assessed punishment, enhanced by a previous felony conviction, at imprisonment for eighteen years and a $1500 fine. See Tex. Penal Code Ann. § 38.10(a) (West 1994). The pending burglary indictment was introduced in evidence by the State during the guilt phase of trial. Appellant concedes that the indictment was admissible to prove that the offense for which his appearance was required was a felony, and thus to establish the district court’s jurisdiction. See id. § 38. 10(f). Appellant contends, however, that the court erred by admitting the enhancement paragraph of the burglary indictment, which alleged a previous felony conviction for aggravated assault with a deadly weapon. He urges that his previous assault conviction was irrelevant to the question of whether he failed to appear for the burglary trial. See Tex. R. Evid. 401, 402. The State replies that the enhancement paragraph of the burglary indictment was admissible at the guilt stage to show appellant’s motive for failing to appear. See Tex. R. Evid. 404(b). Because of his previous conviction, appellant faced a possible life sentence if convicted of the burglary rather than a maximum term of twenty years’ imprisonment. See Tex. Penal Code Ann. § 12.42(b) (West Supp. 2001). Appellant responds that the State’s argument fails in the absence of any evidence that he appreciated the significance of the enhancement allegation. We believe that the possibility of an enhanced punishment upon conviction for the burglary was a fact tending to make it more probable that appellant’s failure to appear was intentional or knowing, even in the absence of proof that appellant had been told or otherwise knew the legal significance of the enhancement allegation. 1 As a consequence, we conclude that the court did not abuse its discretion by refusing to redact the enhancement paragraph from the burglary indictment before admitting it in evidence at the guilt stage of appellant’s trial. If the court did err by overruling appellant’s objection, however, we also conclude that the admission of the enhancement paragraph did not affect appellant’s substantial rights. See Tex. R. App. P. 44.2(b). During jury selection, counsel for both the State and appellant emphasized to the panelists that appellant’s guilt of the alleged burglary offense was irrelevant in 1 Appellant does not contend that the probative value of the evidence was outweighed by the danger of unfair prejudice. See Tex. R. Evid. 403. 2 this trial for failing to appear. 2 Only three witnesses testified at the guilt stage of trial: the owner of the bail bond company, the employee of the bond company who attempted to notify appellant of his trial setting, and the bailiff who called appellant’s name in the courthouse lobby. The only contested issue was whether appellant had been given adequate notice to appear. This was also the subject that dominated the jury arguments at the close of the guilt stage. 3 No reference was made during argument to the enhancement paragraph contained in the burglary indictment. Under the circumstances shown here, any error in the admission of the enhancement paragraph did not have a substantial and injurious influence in determining the jury’s guilty verdict. See King v. State, 953 S.W.2d 266, 271 (Tex. Crim. App. 1997). Appellant’s sole issue is overruled and the judgment of conviction is affirmed. __________________________________________ Lee Yeakel, Justice Before Chief Justice Aboussie, Justices Yeakel and Patterson Affirmed Filed: March 15, 2001 Do Not Publish 2 The prosecutor admonished the panelists that it would be “improper” for them to consider whether or not appellant “committed the other offense. ” Defense counsel emphasized that the presumption of innocence attached to the alleged burglary, just as it did to the alleged failure to appear for which appellant was on trial. 3 Appellant expressly declined a jury instruction limiting the jury’s consideration of the challenged evidence to the issues of motive and intent, and none was given. 3 NOTE: DL has not yet taken the time to put "anchors" into the archives. Translation: You
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, and caregivers are welcome....: The commonly used galvanizedpipe is now mainly used for conveying gas and heating.The galvanizedpipe is used as a water pipe. After several years of use, the tube produces a lot of rust, and the yellow...State Launches Earned Income Tax Credit Awareness Week, Promotes Program to Put Millions of Dollars Back in the Hands of Hard-Working Californians Published: Feb 21, 2017 SACRAMENTO – The Office of Governor Edmund G. Brown Jr. will host a press call tomorrow – led by State Controller Betty Yee, Executive Secretary in the Office of the Governor Nancy McFadden, Chair of the CalEITC4Me Campaign Joe Sanberg and United Ways of California President and CEO Pete Manzo – to discuss the California Earned Income Tax Credit (EITC) program and efforts to ensure more hard-working Californians access these important benefits. Governor Brown’s 2015-16 Budget established the state’s first EITC, designed to complement the federal EITC. California’s poorest working families are eligible for both state and federal EITC benefits. Last year, nearly 400,000 families received the cash-back CalEITC, sharing a total of $200 million. That’s money that went to pay rent, buy food and cover other expenses. However, an estimated $2 billion of combined state and federal EITC were left unclaimed last year. Governor Brown today issued a proclamation to recognize the importance of the CalEITC and to encourage Californians to spread the word about this underutilized resource. CalEITC Press CallWhen: Tomorrow, Wednesday, February 22, 2017 at 10:00 a.m. Call Information: This call is open to credentialed media only. Reporters who wish to join should dial 800-230-1096. Please join the call 5 minutes prior to the scheduled start time to register with the operator and be placed into conference.Well, that hearing wrapped just before 7 tonight here in Washington. Throughout, emotions ran high on all sides. NPR's Tamara Keith joins me now from the White House to talk through the day. Hi again, Tam. TAMARA KEITH, BYLINE: Hello. KELLY: Hi. So Kavanaugh - as we could hear from his testimony, as you could see, he was angry in his opening statement. He was really angry. Is that a different side of him than we've seen before? KEITH: Yeah. He in his original confirmation hearing was very careful to be even-keeled, to present himself as a nonpartisan, impartial jurist - just the law. In his Fox News interview earlier this week, he came across as subdued and sad and confused by the allegations. Today was very different. He was combative. He was partisan. And he sort of fluctuated at times between yelling and other times tearing up - really combative with the Democratic senators in particular. It seemed like he was channeling President Trump in some ways, whose M.O. is always to fight, fight, fight, fight, fight back against everything. KELLY: Speaking of President Trump, we know the president was watching. He has tweeted his reaction. Tell us what he said. KEITH: Well, I will read the tweet. He says - and I will say that he was watching - he had an event to get to, and he didn't leave on time because the hearing wasn't over yet. Then almost - just a couple of minutes after the hearing was over, this tweet came out. Quote, "Judge Kavanaugh showed America exactly why I nominated him. His testimony was powerful, honest and riveting. Democrats' search-and-destroy strategy is disgraceful, and this process has been a total sham, an effort to delay, obstruct and resist. The Senate must vote" - exclamation point. One thing I want to point out about that - the phrase search and destroy is a phrase that Brett Kavanaugh had in his opening statement... KELLY: Yeah. KEITH: ...There at that Senate hearing. KELLY: It sounds as though President Trump is standing behind Kavanaugh's nomination, very much standing behind his nominee, which is interesting because just last night, he was hinting that maybe if things didn't go so well today from the president's point of view, he might pull Kavanaugh's nomination. KEITH: Right. He - in a press conference yesterday, the president was like, well, we'll see how it goes; I want to see if the allegations against him are credible. But that is not what happened today. Today, President Trump came out very strongly in favor of his nominee, as did... KELLY: And do we know why... KEITH: ...Vice President Mike Pence. KELLY: ...I mean, what it was that he heard that he liked? KEITH: Well, I think in part it was that he was combative. I've been told by aides that they felt that the opening statement was strong, that they felt that, you know, if all the Democrats could get on him is that, you know, he drank in high school and college, then that wasn't enough to take him down. And White House aides were cheering on Senator Lindsey Graham, who in the hearing was the one who really took control and changed the way the hearing was going, making it much more partisan. (SOUNDBITE OF ARCHIVED RECORDING) LINDSEY GRAHAM: God, I hate to say it 'cause these have been my friends. But let me tell you when it comes to this. You're looking for a fair process. You came to the wrong town at the wrong time, my friend. KEITH: One other small thing to note is that President Trump did not weigh in on the credibility of Blasey Ford's testimony. KELLY: So real quick, what happens next? KEITH: There's going to be a vote. We are told that the Senate Judiciary Committee is going to convene tomorrow morning, and a vote is expected in committee there, and then it could go to the full Senate pretty quickly.Turns out we aren't as good at selling games as we thought! It's time for a radical change! Looking at our busy release schedule you probably wouldn’t have guessed, but in the last two months of 2013 our office has been largely empty. There was no programming, no designing, no fun to be had, just co-founders Martijn and Collin taking care of the business end of things. In this case the ‘business end’ can be taken quite literally. The old Two Tribes, founded in 2001, doesn’t exist anymore and we had to send everyone home. Before we go into details… The Facts The old Two Tribes B.V., who employed the developers, is now gone. Its parent company, Two Tribes Publishing B.V., that owns and publishes all our games and handles all contracts, remains unaffected. A new daughter company has been formed and it will handle the development of future titles. The original founders Martijn Reuvers and Collin van Ginkel aren’t going anywhere. With that out of the way, let’s say goodbye first. Bye Old Friend! We’ve been making games for more than 13 years, so you can imagine how much it - quite frankly - sucks when after a four minute meeting at the courthouse, the company we built was no more. At the same time, we knew we were kinda stuck in the past and this was our chance to change things drastically. In 2009 we started the transition from doing work for hire to becoming the Indie studio we had always wanted to be. We’re super proud of what we’ve achieved in recent years, but the company that resulted from that transition still held on to too many ideas and values from the old days. It’s difficult to make fundamental changes, but late October last year we had no other option. When Toki Tori 2 ended up taking way longer than expected and not achieving the sales we needed, it basically took the company down with it. There’s a lot to learn from what went wrong and what we could have done better and we’ll definitely write up a few blog-posts in the future on that! But now it’s time to move forward and look to the future! Reboot! For the outside world nothing much will change. Two Tribes Publishing is still in good shape and all our previous games will remain for sale. With the support of you, our players, the games will supply the funding for our new titles which will be released under the Two Tribes name. We’ve got a ton of hindsight to work with and we’re going to be applying the lessons we learned to the new Two Tribes. Behind the scenes things will change quite a bit. We’ve decided to move away from creating custom technology and focus on what’s readily available. As a result we’ll be working with a much smaller team on our next game, a 2D side scrolling shooter, which will be re-using the existing Toki Tori 2+ engine. Our focus will be on the design of our games, which we plan on making more of in less time than before. A Massive Thanks! We know it has been a rough couple of months for everyone involved, most of our natives spent between four and nine years of their lives at Two Tribes.
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and the train slowly lost speed. I was already in my robes so all I had to do was make sure my stuff was ready to be removed from the train. I always hated that part, leaving my trunk on the platform for some stranger to manhandle up to my dormitory. Thankfully it had a powerful curse on it, thanks to my father who'd been the one to teach me, that made sure anyone who tried to force open my trunk would suffer a nasty shock. But there was one thing of mine I wasn't letting them get. I stood up and pulled the small wicker basket off the overhead storage. The spare robes I'd flung over it wriggled slightly and I pulled them back to reveal the only living creature I didn't hate on sight. Ghost, my cat. Up until fourth year I'd had an owl but Malfoy had hexed it and after that the owl never really flew right again. So when I'd come home last summer and found a scrawny white kitten in the garden, looking like it was about to starve to death, I decided he was mine. A year later he was still a scrawny little thing but his claws were sharp and he didn't leave my side. He miaowed as I moved his basket and I scratched under his chin to make sure he knew it was okay. With him purring contendedly on my lap, I sat closer to the door, the train slowing considerably now. If I could get on one of the first carriage up to the castle I might have time to put Ghost in the common room and still make it in time for the feast. Not that I cared about being on-time, or not getting in trouble, I was just simply hungry. The rest of the ride was thankfully silent, although I was aware of Professor Lupin studying me intently from time to time and there was no mistake that Malfoy was plotting some sort of revenge. I remembered him from my time at the school; he didn't handle being told what to do very well. It wasn't over yet, but I didn't mind. It could even be fun, I realized. Once the train started slowing down I put my book away, standing up and flattening down my robes a little. I'd changed into them much earlier, even though I did mostly wear muggle clothes when I was out and about or just in my own home. Lupin got up as well, his scrawny form fixing the robe he was wearing as much as he could. When the train came to a complete halt I waved my hand at Malfoy, my wand - ebony, 13 inches, thestral tail hair for a core - hanging in my other hand, taking care not to point it in the student in a threatening way. "After you, Mr. Malfoy," I said sweetly. "We'll be riding in the same carriage, so we can visit Professor Dumbledore together." "I look forward to it," Draco smiled back, his smile and polite tone as fake as the professors. He was tempted to get his own wand out as he eyed her, wondering if she'd curse him the minute they were alone but he forced himself to saunter past the shabby professor. The threat of seeing Dumbledore hardly had Draco shaking in his robes, the old fool probably wouldn't even care. As Draco got to the door he looked out and saw McKinley shooting straight out the doors, obviously wanting to get off the train as quickly as possible. Most other students were still chatting and laughing and the new first years were milling around looking totally lost. But he ignored them and fixed his eyes on the doors McKinley had left out of, hoping he could catch up with her. "Shall we go then?" He turned to smirk at Hastings, hoping it would irritate her into moving a little faster. -- I elbowed my way past a few Hufflepuff students who were in my way as I got to one of the first carriages. I kept my eyes fixed on Ghost, who was still purring contendedly in my arms. Most people at school had owls, which were hooting in cages set on top of the trunks piled up on the station platform. If people were stupid enough to trust their pets with someone else, that was their choice and I wasn't going to bother with them. I scrambled on to the empty carriage, keeping a tight grip on Ghost as he squirmed a little in discomfort. Once I was seated we both settled down to wait for the carriage to fill up, unfortuantely I had to put up with other people. I just prayed it wasn't somebody too annoying. "After you," I said, smile still sweet. Lupin had also made a move to leave, and I allowed the both of them to walk ahead of me. I knew that the threat of the Headmaster wouldn't have Malfoy shaking in his boots, but I also knew that I had to reassert myself in front of the student. And my fellow teacher, for that matter. Draco shuffled his way through the corridor, dodging students and their luggage. He was half tempted to try and lose the teachers in the crowd but he knew he didn't have the guts to pull that kind of move so he trudged his way to the carriage and as they approached the castle he wondered absent-mindedly if he'd miss the feast or not. -- Once I'd gotten to the castle I hurried my way inside. I'd been forced to share my carriage with a couple of Gryffindor's, one of them that curly-haired know-it-all girl who was always correcting me in class. Though without any teachers around to keep her safe she didn't have anything to say to me, funnily enough. I half-jumped down the stairs and used the password, "Magic is Might" to enter the passage. The common room was one of the few places I liked about Hogwarts, the windows underwater and the sound of swishing water filling the room as I went up to my dormitory. I placed Ghost on my bed and scratched him under the chin. "Now behave yourself and I'll try and bring you back some chicken from the feast," I said quietly, smiling at his purring and glad that nobody was around to hear or see me. "I'll be back soon." I have him one last pet before going back the way I'd came, hoping I'd not missed the feast. I didn't take my eyes off of Malfoy for a second while we headed for the Headmaster's office. Lupin had offered to come with but I brushed him off as politely as I could. I didn't need his help; I could definitely take care of it myself. While waiting for Dumbledore to let us in I drummed my fingers against my thigh absentmindedly. As soon as I saw the Headmaster a genuine smile spread across my features. I did like Dumbledore, in spite of sometimes trying to deny it. "Professor Hastings, Mr. Malfoy," he said, peering at us from behind his spectacles. "Mr. Malfoy here thought he'd start off the year by breaking school rules and threatening a teacher - I figured he could then also start it off by seeing you." I grinned at him, although my voice showed I was serious. He sighed, although I wasn't sure if it was aimed towards me or Malfoy, and invited us in. I took a seat across from him after he'd returned to his spot behind the desk. "So, threats?" he said, leaning into his hands. That peculiar look he sometimes had was on his features, and I had to fight a smirk. "Apparently Mr. Malfoy wants to ensure that my teaching days are cut short, by telling everyone of what I 'did' during my final year at Hogwarts." I stretched the word slightly, and gave the Headmaster a wink. No doubt he'd remember exactly what people had been saying about me. As well as how much of a lie it was. "Is that so?" He glanced towards Malfoy. "I would like to assure you, Draco, that Professor Hastings was an exemplary student. Regardless of what you might have heard, none of it is true, and I will make sure that everyone knows it. Personally, if I have to. I will of course have to speak to Professor Snape about your behavior, but I warn you not to get on Professor Hasting's bad side. Because although those rumors aren't true, she does have one." When he spoke the last part he threw me a glance, one filled with both amusement and the words 'tread carefully'. I grinned again. Draco bowed his head, barely listening to the headmasters words. He longed for the day that they got a new head of school, one who actually knew what they were doing and didn't favour absoloutely useless people like Hastings or Hagrid. He didn't especially care about the threat of Snape finding out but he tried to make sure his face looked like he did. Once they were done talking, he nodded. "Yes, Professor Dumbledore, I'll be sure to remember that," he said, just wanting to get this meeting over with. -- Thankfully the feast hadn't started when I got to the Great Hall and some teachers hadn't even arrived yet and students were filing in. I took my place at the Slytherin table, ignoring the chattering that filled the hall
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known to pull such tricks, she’d said, changing the paperwork so that young boys could enjoy the salvation of twin status. Hedvah cited their different hair colors —Lino was a redhead, Artur a brunet— as evidence that they were impostors. But they had to be twins. I could tell by the way that they sat in their chairs. They showed the same shock, the same trembles, as the nurses counted and measured their every feature. Not a single gesture toward identicality was overlooked—their eyelashes were counted, their eyebrow hairs, the flecks in their eyes, the dimples at their knees and cheeks. They were added and subtracted and compared, two human equations who could only squirm in their seats. And there were Margit and Lenci Klein, from Hungary. Six years of age. Whenever Pearl and I were immeasurably sad we looked for them, because they reminded us of how we’d been as younger girls—hands entwined, full of secrets and the occasional elbowjab of annoyance. They were always combing each other’s hair with their fingers till their strands shone and making whistles out of blades of grass. Their mother had left them with instructions to always wear purple hair ribbons to make it easier for her to spy them in a crowd, so they fastened them atop their heads every day, first thing, propping them up so that they stood like velvet ears on their heads. We watched as the nurses diagrammed their pale, goose-bumped forms with red ink, circling a piece here, a bit there, until their bodies were rivered with scarlet. The fifth subject stood alone, his thumb hooked in his mouth. He could have been thirteen or thirty-five or sixty, he was so whittled, so beyond age. His nurse was leafing through files with an air of boredom, as if there were nothing left to be done with him. Before her on a table were two folders, two sets of photographs, two sets of diagrams, two sets of x-rays. But there was only one boy. And he was an iota of boy, a frailboned brevity with an overbite and teeth that splayed themselves over his lips like a crooked fence. Tufts of whitestreaked hair nested on his scalp and obscured his eyes, which seemed unable to focus on anything but the ceiling above. His veins stood so close to the surface of this boy that in the hospital’s faulty lights, their clusters lent his skin a pronounced hue of illness. In his chill and suffering, he was near blue. I fixed my eyes on him, hoping he might sense me and stare back, the way twins often do, but the boy only coughed showily, making no effort to disguise his sickness. The nurse frowned at him disapprovingly and boxed up half of the file—this action appeared to disturb the boy. I watched him sway where he stood and falter at the knees, and though I was sure that he was about to collapse, he simply stared at the box with all the reverence one might have for a grave, and then he reached toward it and tried to run a finger over the lid but the nurse slapped his hand away, and he withdrew like a wounded thing and inserted his thumb in his mouth again. The nurse declared him finished and gestured to him to dress, but he refused to accept his clothes, even as she thrust the garments forcefully at his sunken chest. It was as if he’d decided that nothing was graspable anymore, that there was no point in trying to hold anything other than a thumb to one’s mouth. Agitated, the nurse threw the garments at his feet and stalked off. And still, he stood bluely naked, refusing to follow her orders. He turned only to cough in her direction, and that’s when our gazes finally met. I looked away as fast as I could, which was slow enough to receive his friendly nod and quick enough that I could avoid returning it. I couldn’t face what he had endured, the horrors of which were made too obvious by the empty chair at his side. “I understand what you are saying,” he said to the empty seat beside him. “But our father, if he were here, he would say that curses curse their utterers. And our mother, if she were here, she would say—” And then he fell to coughing again. It was the boy and his empty chair that moved me to decide: I would be more than an experiment in this world. I was not as smart as Uncle Doctor, but I could study his movements without him knowing, and learn about medicine, and use him to my advantage. Pearl had her dancing to look forward to—I needed my own ambition. After all, when the war ended, someone was going to have to take care of people. Someone was going to have to find the lost and put all the halves together. I saw no reason why that someone could not be me. I planned to begin my practice with the boy. Not knowing his name, I decided to call him Patient Number Blue. I studied him, taking in what I could from a distance, but before I could think too much on his particulars, I was interrupted by a high, trilling note. Uncle Doctor. He entered whistling with a sprightly step, smelling of peppermint and starch, the long white wings of his coat trailing against each surface he passed and erasing them. I’d come to learn that he considered himself an expert at whistling, just as he considered himself an expert on hygiene and culture and art and writing. But while his whistle was errorless, there was no mistaking its robotic lean. Even as it leaped about the scale, it was monotone at the core, a hollowed thing that couldn’t know a feeling. I tried to mimic this hollow whistle, but I found myself unable to copy the doctor’s trill—when I put my lips together to blow, I could only sputter. Uncle saw this mishap and smiled. It was an amused expression that might have seemed harmless to an outsider, but the arc ofCan the electrophysiologic study predict treatment outcome in patients with sustained ventricular tachyarrhythmias unrelated to coronary artery disease? Sustained ventricular tachyarrhythmias unrelated to coronary artery disease are uncommon. Currently there are no clear guidelines to aid selection of the most appropriate treatment strategy. Therefore, factors potentially predictive of arrhythmia recurrence and death and the ability of the electrophysiologic study to predict treatment outcome in patients with spontaneous sustained ventricular tachyarrhythmias unrelated to coronary artery disease were examined in 41 medically treated patients followed for a median of 25 (range 1-76) months. Examined factors were: syncope associated with the spontaneous arrhythmia, the morphology and cycle length of the presenting arrhythmia, underlying ventricular function, cardiac pathology, and the results of drug assessment at electrophysiologic study. Random variability in the ease of arrhythmia induction at electrophysiologic study was measured for the group as a whole and was allowed for in prediction of an effective drug response. The 95% confidence intervals for variability in the ease of repeat arrhythmia induction at the same study were < or = 1 extrastimulus and for variability in the ease of repeat arrhythmia inductions at different studies were < or = 2 extrastimuli. Poisson regression models were used for data analysis. Arrhythmia recurrence was most likely in: (1) patients on treatment not predicted to be anti-arrhythmic at electrophysiologic study; (2) patients whose treatment was not assessable at electrophysiologic study because the arrhythmia was not reliably inducible; (3) patients with impaired ventricular function; and (4) re-entered patients whose arrhythmia had recurred on previously allocated therapy. The risk of arrhythmia recurrence decreased with time from hospital assessment. All five deaths occurred in patients with impaired ventricular function. drug efficacy should be tested at electrophysiologic study in patients with reproducibly inducible clinical arrhythmias. Treatment not proven to be anti-arrhythmic at electrophysiologic study is usually ineffective. Patients with ventricular dysfunction are at highest risk of death from arrhythmia recurrence and should be considered for an implantable defibrillator, arrhythmia surgery, or heart transplantation if drug treatment is not predicted to be effective or is not assessable at electrophysiologic study.Q: Regular expression - range of the match I have the following regular expression: re.findall(r'(\b[A-Za-z][a-z]{3,10}\b)', string_var) I expected that this regular expression will return matches with the length ranging from 3 to 10. It however returns matches for words ranging in length from 4 to 11. Do we thus read the above regular expression as matching those words which start with an upper case or lower case letter, followed by letters ranging
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." " Well, you are welcome to your opinion," retorted Ju- dith, almost angrily. " But it seems to me if Jesus gets a good honest wife among more common people, he may count himself lucky." Then turning to Susanna, whose absorbed attention was so apparent, Judith changed her tone, and went on very sweet and smiling. " Perhaps we ought not to talk so freely about Jesus in the presence of Susanna, the subject seems so painful to her. I beg your pardon, Susanna. We will talk of something else." Susanna, startled as if from a reverie, fixed her eyes as if in pained surprise upon the speaker, and then, with- out a word and drawing her wimple about her face, turned and walked slowly away. " Why, the girl has gone and left her water-pot," ex- claimed one, then called more loudly, " Susanna! Su- sanna-a! You have forgotten your water-pot! " But Susanna did not turn or pause, and went straight on. " Now that was too cruel of you, Judith," said Zibiah, with some show of reproof. " How could you do it " "Do what How was I to know that the silly girl was going to be hurt by what I said But my husband will be waiting, and I must go." And Judith, taking up her water-pot, stalked proudly away. " What a mean, cruel thing that was for Judith to say to Susanna," said Zibiah, as soon as Judith was out of hearing. "Well, you know, of course, what the matter is with her," answered Athaliab. " I don't care, it doesn't excuse her," returned Zibiah. "And for her to think that her poor little Hushim could 262 AT THE FOUNTAIN get Jesus for a husband, when he doesn't seem to care for the finest maidens in Nazareth, neither Susanna nor anyone else." " No, Jesus, will never marry, I doubt," answered Athaliab. " They say he is still thinking of Mary of Magdala,- though that seems entirely impossible, for she has gone wholly to the bad, as everyone knows. And then, besides, they say that Jesus will never be a real Rabbi. He knows enough, no doubt. My husband says he is equal in knowledge of the Law to Hillel or Shammai, but that he has such queer notions he can never be re- ceived in Jerusalem as a Rabbi. He is friendly to the Zealots, and they say he has lived with the Essenes at Engedi, when he has been off so long." " Yes, and now," broke in another, "his cousin John the Hermit is teaching a new doctrine at Bethabara, and they say that Jesus is one of his disciples, with both his brothers and all his cousins and uncles." Another woman, who had not yet spoken, here inter- rupted. " Yes, and John the Hermit they are now calling John the Baptist, for they say he is baptizing everybody in a new way,-plunging them all under water, head, neck, and heels; and that, he says, washes away all their sins and saves them from a terrible destruction which he asserts is now close at hand. My husband and I and a lot of people from our street are going out to-morrow to see what it is all about. We hear they are going from Cana and Capernaum and everywhere." " Let them go, the more fools they," cried Athaliah. "But then this is Sabbatic Year, and idle people must have something to amuse them. Only look out you don't get snared. My husband says that this John is really a Zealot, like Jacobus and his father before him, and will surely be snatched up sooner or later by Antipas or the Romans, and all who have anything to do with him will suffer. Every little while some such fool adventurer starts 9!63 264 JESUS OF NAZARETH up with some wild scheme, like old Ezekias and Judas the Gaulonite and Simon and Athronges and his brothers, and they all have miserably perished; and so will it be with this John. Better keep away from him and be satisfied to live on in the good old way." Further conversation is here cut short by the approach of a tumultuous crowd of swearing, singing, shouting men and boys, with camels, mules, asses, and horses, coining for a supply of water. They belong to the caravan from Tyre and Sidon that is camped for the night on the plain above, where there is no water. The women, drawing their wimples close about their faces, seize their water-pots and go hastily away. We are glad to see one, who had not spoken, take up the full jar left by Susanna and carry it along with her own. " Poor girl, she will be scolded for not bringing it," she murmured, " and I will take it to her." XXIX TO HEAR JOHN "Caravans of men and beasts covered the roads of Galilee and Judea and the plain of Jordan."- JOSEPHUS. It was Spring-time when John began his ministry. It is now Autumn; and the waters of upper Jordan are dried up, so that baptism by immersion can no longer be per- formed there. So John has removed first to Enon and afterwards to lower Jordan, the only place where a suffi- cient depth of water can be found. It has been a period of great activity for John. Into these few months have been crowded the labors of a lifetime. As with Him who was to come after, and whose shoes John felt himself un- worthy to unloose, the stored-up result of long years of solitary wrestle with the great problems of life was to blossom in an hour, and leave fruit to ripen slowly in the growing light of all the ages. Until the excitement had become so great and the move- ment so universal as to become national and to endanger the very institutions by which they lived and grew, the rich and great, the priests and professional gentlemen, held aloof. But already there had been danger signals abroad, indications that this movement, if allowed to pro- ceed, would abridge ancient privileges, lessen the respect paid to wealth and position, and, above all, reduce the revenues! Such results were surely indicated in the diminished at- tendance at the stated feasts at Jerusalem. The Feast in July, when the wood for Temple service was contributed, had shown a falling off, and now but lately, at the Feast of Trumpets, or New Year, one of the three most solemn festivals of the Jewish year, there had been an alarming 265 JESUS OF NAZARETH decline. The money and gifts flowing into Jerusalem to enrich the priesthood and officials was greatly reduced. These disturbing conditions were first observed by the Temple priesthood and officials, by whom the loss was most felt. They called the attention of Caiaphas to it and recommended active measures, but Caiaphas and the higher priesthood were so sunk in luxury and sloth that they were slow to move. Old Annas alone, the father-in-law to the weak and pro- crastinating Caiaphas, was fully alive to the occasion, and capable of energetic action. Annas, a former High-Priest, a man of immense wealth and with influence at Rome, be- longed to a former generation. A Sadducee of the Sad- ducees, his religion was no more than a Hebraized Pan- theism. But his morals were founded on sound philosophy, and to old age he had preserved the force and energy that made him, though old and without office, the leading and controlling spirit in sacerdotal affairs in Jerusalem. He was still the virtual High-Priest. And about him began now to form that secret cabal which was so cruelly to cut short the career of John, and a year later on Calvary to give what seemed the finishing blow to the great Denmo- cratic uprising in Israel. Annas, as one of the few who had access to Pilate, had at first attempted to engage that vigilant ruler in a hostile movement, and Pilate, as a measure of precaution, had sent Varus in disguise to take notes of John's preachings and learn its real design and tendency. Varus' report had wholly satisfied Pilate, and no arts of Annas could move him to interfere. Besides, Procula, Pilate's wife, had spent her girlhood in Galilee, and was a somewhat in- telligent interpreter of social and religious movements which had their origin outside of Jerusalem. With Antipas Annas had been more successful: his representations had aroused in that weak and superstitious ruler the darkest suspicions. His agents were constantly on the watch, and 266 TO HEAR JOHN there was now no day but spies from Tiberias as well as from Jerusalem were in attendance on the preaching of John. Under John's vehement harangues the whole of Palestine, from Hebron to farthest Lebanon, became dis- rupted and in motion. Caravans of people of all ages, sexes, and conditions filled every highway and bypath. There were Priests and Levites, criminals and prostitutes, Sadducees and Zealots, the friends of Rome as well as its enemies, the skin-clad herdsmen of Bashan and the decked and gilded nabobs of Jerusalem. Pilate and his Romans alone remained calm and indif-
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WINFREY: But you could have done what–do you think now you could have done what Conan did? When they came in and said your prime time show’s canceled, you say okay, you owe me two years, because that’s what you said at the beginning. Mr. LENO: Right, right. WINFREY: You were guaranteed at least a year. Mr. LENO: Right. WINFREY: Two years if you were successful. Mr. LENO: Right. WINFREY: Pay me out, pay out my staff. You could have done that. Mr. LENO: I could have done that, but I didn’t. They offered me my old job back. WINFREY: Right, I get that. Mr. LENO: Which is the dream job. I said okay. WINFREY: Is there a bigger lesson in all of this? Mr. LENO: The key is not to be bitter and I think Conan said it best when he said don’t be cynical. WINFREY: Mm-hmm. And yet you said earlier you haven’t called him? Mr. LENO: It’s not the right time, because I’m not sure what I would say right now. Let some time pass and I would hope we can talk again. WINFREY: Will you have him on your show? Mr. LENO: I would love to. I don’t know whether he would do it or not. I think he will have a successful show on Fox or somewhere else. WINFREY: Wherever he goes. Mr. LENO: And then we will all compete again and may the best man win. [COMMERCIAL BREAK] WINFREY: So we’re live in Chicago. I’m with a cold and a cough drop. That was Jay’s side of the story and really I want to say I appreciate you talking to me, Jay. And just so you all know, we reached out to Conan’s people for an interview, and they told us that it’s not the right time. So, Conan, the offer still stands. When you are ready, I have a seat for you. So as we saw earlier, people were very pro-Conan in our Oprah.com poll, so when we go off the air in a few seconds, I’m going to hang out with this audience and we’re going to find out how they feel about this late night fiasco. And we’ll put it up on the homepage of Oprah.com. For those of you in Chicago, you can see it this afternoon, because as you know, we’re live at 9:00 in Chicago. So starting at 4:00, everybody else, log on right after the show airs in your town and you can see what the audience has to say. And while you’re on our website, please take our No Phone Zone pledge and help us to stop this insanity of texting and talking on the phone while driving. I’ll see you on Oprah.com, everybody. http://twitter.com/share?text=Jay and Oprah: The Full Transcript&via=TheWrap&url=http%3A%2F%2Fwww.thewrap.com%2Fjay-and-oprah-full-transcript-13636%2F&t=Jay and Oprah: The Full Transcripthttp://www.facebook.com/sharer.php?u=http%3A%2F%2Fwww.thewrap.com%2Fjay-and-oprah-full-transcript-13636%2F&t=Jay and Oprah: The Full TranscriptQ: Use pipes in css Angular 9 I want to put a text through the translate pipe, but the text is in the css in content. .files:before { position: absolute; content: "Drag your files here"; } This does not work: .files:before { position: absolute; content: {{'file.text' | translate}}; } A: Not sure if this going to work. By using pipe you can change the content in the HTML part, so just bind to some attribute in the DOM and try to read from there in css like this - .files:before { position: absolute; content: attr(data-lang) } For example you have DOM element, you need to add data attribute like mentioned below - <p data-lang="en">Any content here </p> Q: Unit test an attribute directive in Angular 2 I am trying to unit test a custom maxlength directive having an Input parameter. The directive looks like: import { Directive, Input, HostListener } from '@angular/core'; @Directive({ selector: '[limitTo]' }) export class LimitToDirective { @Input() limit: number; constructor() { } @HostListener("keypress", ["$event"]) onkeypress(event) { if (event.target.value.length === this.limit) { event.preventDefault(); } } } The unit test looks like: @Component({ template: `<input type="text" limit="8" limitTo>` }) class TestMaxLengthComponent { } describe('Directive: LimitToDirective', () => { let component: TestMaxLengthComponent; let fixture: ComponentFixture<TestMaxLengthComponent>; let inputEl: DebugElement; beforeEach(() => { TestBed.configureTestingModule({ declarations: [TestMaxLengthComponent, LimitToDirective] }); fixture = TestBed.createComponent(TestMaxLengthComponent); component = fixture.componentInstance; inputEl = fixture.debugElement.query(By.css('input')); }); it('should do something', () => { const event = { target: { value: '12341111' }, preventDefault: function () { } }; spyOn(event, 'preventDefault'); inputEl.triggerEventHandler('keypress', event); fixture.detectChanges(); expect(event.preventDefault).toHaveBeenCalled(); }); }); When I am running the unit test, I am getting an undefined value for limit. Why is that value undefined? A: Move fixture.detectChanges() to the top. it('should do something', () => { fixture.detectChanges(); const event = { target: { value: '12341111' }, preventDefault: function () { } }; spyOn(event, 'preventDefault'); inputEl.triggerEventHandler('keypress', event); expect(event.preventDefault).toHaveBeenCalled(); }); Also I think you need to change you directive to convert limit string to number: if (event.target.value.length === +this.limit) { From GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning. The electrical activity of the heart depends on the correct interplay between key transcription factors and cis-regulatory elements, which together regulate the proper heterogeneous expression of genes encoding for ion channels and other proteins. Genome-wide association studies of ECG parameters implicated genetic variants in the genes for these factors and ion channels modulating conduction and depolarization. Here, we review recent insights into the regulation of localized expression of ion channel genes and the mechanism by which a single-nucleotide polymorphism (SNP) associated with alterations in cardiac conduction patterns in humans affects the transcriptional regulation of the sodium channel genes, SCN5A and SCN10A. The identification of regulatory elements of electrical activity genes helps to explain the impact of genetic variants in non-coding regulatory DNA sequences on regulation of cardiac conduction and the predisposition for cardiac arrhythmias.A proposed model to monitor heparin therapy using the concentrated thrombin time which allows standardisation of reagents and improved estimation of heparin concentrations. The concentrated thrombin time (CTT), a thrombin time performed with a high concentration of thrombin, was evaluated as an alternative to the activated partial thromboplastin time (APTT) for monitoring of heparin therapy. Forty-nine plasmas from patients receiving unfractionated heparin therapy were tested. It was first demonstrated that CTTs using three commercial reagents could be standardised against CTTs performed with a reference reagent, MRC reagent 66/305. For comparison, APTTs were performed on the plasmas. As a benchmark of the degree of heparinisation, the heparin concentration of the plasmas was determined by chromogenic anti-IIa heparin assays, therapeutic range being 0.2-0.4 units/ml. The optimal relationships of the CTTs and APTT with the heparin concentration were established. These were used to predict the heparin concentrations of the plasmas from the results of the APTT, CTT performed with the reference reagent, and transformed CTT performed with each of
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jilted, didn't you?' he interrupted me. I felt my hackles rise like they had with Blaise. I had to put a stop to this angle they were clearly looking to go down. I cleared my throat and sat upright. 'Yes I did. But honestly, Jerry, I don't want to be known as "the jilted bride".' I made inverted commas with my fingers and cringed. 'I was dumped, and yes that was the catalyst for going away but that is all in the past now. I've made something out of what was a horrible time and I couldn't be happier.' He was nodding along and making notes as I spoke. I felt really hot all of a sudden. 'I don't want this part to be a big element of the show. Rahul told me it would be more looking at how Ben and I manage our time working on the business, and our passion for travel. Is that okay?' 'Mmm. I just have to ask these silly questions,' he said gently. 'I'm sure it won't be the main focus of things.' 'Okay, well if you could note that down please, I'd be really grateful.' Jerry leant forward and put the papers to one side. 'Georgia, we're thrilled to have you both here today and we only want you to feel happy. Please trust me that you honestly don't have a thing to worry about when you're away, well apart from maybe applying sunscreen and mosquito repellent!' He laughed. I smiled along with him. Jerry looked like someone my dad would hang out and have a beer with in his local. There was no way he'd stitch me up. _Stop being so dramatic, Georgia_. They just need to cover all bases to check you haven't got any nasty skeletons hiding in your cupboard, I tried to tell myself. Then a thought hit me: I wondered what Ben was talking to that glamorous woman about. What questions was she asking him? See, this is going to be great, you can finally learn more about each other without feeling like you're nagging him, my subconscious said smugly. The next hour or so passed quickly as Jerry moved on to less interrogative questions about running a business, the skills needed and time-management difficulties, then touched on how dating and working together with Ben was. He was apologetic about asking tough questions and made me laugh as he told me about his wife and how they'd tried to work together once but it had almost ended in a divorce. 'So.' He glanced at his brown leather watch. 'I'm conscious of time so if you could sign this form and then we can get started on sorting out the travel arrangements, your passport details, dietary requirements and all of that.' 'Oh, well I wasn't actually planning on signing anything, not until I'd at least spoken to Ben about it all first, sorry.' I winced feeling very awkward. Jerry nodded politely and got to his feet and rummaged in his desk, 'Course. I just need to get the paperwork, that I know I put in here somewhere, so you can have a read of it all.' I nodded slowly and watched him banging open drawers. 'Ah, here we go!' Just then, the phone rang. 'Hello? Excellent. I'll let her know. Yep we're nearly all done here. Great okay, bye.' Jerry hung up and flashed me a heartfelt smile before putting his thumbs up in a cheesy dad style. 'That was Anna, who was with Ben. She just wanted to let me know that he's just signed the contract and will be waiting for you in reception.' 'Oh right. Okay.' He'd signed it already? Jerry handed me over a stack of papers that had been stapled together at the top. 'It's just your basic contract that covers things like insurance and some boring legal jargon.' I must have hesitated before taking it. 'Don't worry, Anna has run through it with Ben who must be happy with it all. It's all kosher. The reason we need to move quite quickly on all of this is that the filming is set to take place in the next few weeks. I only found out this morning that Channel 4 have let us know of an unexpected slot in their scheduling so everything has been bumped forward to give ourselves the best shot to fill it.' I smiled weakly and took the forms. I couldn't believe that Ben had just signed it. _But isn't this what you wanted?_ I asked myself. _You were the one who suggested taking Rahul up on his offer in the first place. Maybe Ben knew how excited you were and wanted to make you happy by showing you that he was on board with the idea?_ I tried to shush the prickling feeling that I was about to sign a contract without running through it with a fine-toothed comb. 'Have you got a pen?' I looked up at Jerry. He nodded and fumbled in one of the messy drawers for a fancy ballpoint pen that glided across the pages where I scrawled my signature. 'Excellent.' Jerry beamed and took the papers from me. 'I'll get these sent off to the legal department and ask them to forward you both a copy for your records and all that stuff.' I nodded as he cleared his throat and leaned forward. 'I know that you and Ben are going to have a wonderful time, be incredible contestants, and I have no doubt that the nation will warm to you and what you're trying to achieve with your business.' 'Thanks, I hope you're right.' I gave a light laugh. _Forget about stressing that you didn't get to fully read every line of that contract. Trust Ben and remember that both lovely Rahul and Jerry here just want to make a light-hearted show. I mean, it's hardly going to be question time with Jeremy bloody Paxman, is it?_ I could have laughed about how sensitive I was being. _We get a free holiday and get to promote our business. What could possibly go wrong?_ 'So, Georgia, someone will be in touch regarding travel arrangements and what things you'll need to bring with you et cetera, et cetera. You will need to keep the seventeenth free. Which I know is very soon, but like I said, everything has been shifted forward. Is this still going to be okay?' I mentally ran through my diary. January was set to be our quietest month, Conrad and Kelli were perfectly capable of being in charge for less than a fortnight, Jimmy and Shelley didn't leave until next month and Marie still had three weeks left until her latest mini-me entered the world. 'Yep, I can't see there's going to be any problems.' I got to my feet as he suddenly seemed quite keen to get me out of the room. 'Great, well it was so lovely to meet you and I'm sure we'll see you again soon. We're thrilled to have you both on board for what's guaranteed to be a fun and memorable experience! I'm just jealous that I've not been asked to take part with my wife!' He let out a deep laugh and then picked up the phone once more and asked for Dog Lover Dana to escort me back to the main room before shaking my hand again. 'Good luck, Georgia!' I said goodbye and followed Dana who was chatting excitedly about the fantastic concept and how lucky we were to be involved. I half tuned out, feeling like I'd emerged from some strange comforting bubble, and now that I was back in the bedlam of the hipster courtyard I had this strange sinking feeling that I'd been way too hasty. It was all going to be fine, wasn't it? Wasn't it? CHAPTER 7 _Inveterate (adj.) – Confirmed in a habit; habitual_ 'Well, that was different,' Ben said smiling, as he pulled out a pair of gloves from his coat pocket. We'd left the television studios and had managed to hail a black cab. Thankfully we had snuck out without getting Blaise-d once more. _Please don't let him be part of the actual filming,_ I said in silent prayer. Although nothing could put a dampener on travelling with Ben, it certainly would be a lot harder with Jazz Hands McJazz Face there. Ben seemed in a really great mood, whereas I felt a little confused and dazed by what had just happened in that room with calm Jerry and his kind eyes. 'I was a little sceptical when you first mentioned this TV show thing, babe, but actually I've been thinking and I reckon it's going to be great for the business.' 'And us?' I pouted. He laughed and wrapped his arm around my shoulders. 'Yeah, and us, of course. Although, I think we're pretty spot on. They say you can't beat perfection.' He let out a bark of a laugh as I pretended to fake vomit. Although inside I felt like that too. 'You did look over the contract properly?' I asked for the third time since we'd left. He gave me a look. 'Yes. I've told you, Georgia, we have nothing to worry about. It was just your basic agreement, like I've said. Trust me, it's fine.' I nodded and told myself to do just that. 'Where to, folks?' the cabbie interrupted us as we pulled out of the courtyard. 'We're done earlier than I thought, so we
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The midfield is the one area in which we look alright. As a squad we look all uneven and middle-heavy, like a professional darts player, but without the predatory instincts of a Phil Taylor type, the fat sweaty danger. Tom Cleverley and Gerard Deulofeu are both good additions and will slot right in. There would have been questions over signing Cleverley had he commanded a fee but he was a free transfer, he’s versatile, he’s keen to prove himself and most of all he IS NOT AIDEN MCGEADY. Deulofeu is a prodigious talent who was popular when here two years ago on loan, he’s more mature than before, he provides width and energy, plus he IS NOT AIDEN MCGEADY. Another winger would be sound, mostly for their un-McGeady-ness, but what we really need is that creative No.10 type, that player who drifts through the game at times but then provides that sumptuous, inch perfect pass that helps us win games. Think of your Mesut Özils, your David Silvas, your Eden Hazards or your John Ebbrells. Wait, that’s not right. Eden Hazard tends to drift out wide. Steven Pienaar has that sort of intelligence, but I’d really like us to get a number 10 who doesn’t have muscles made of jelly. Up front…OK, first things first. Can we please stop calling Conor McAleny a “bright young talent” or a “future prospect”? Here’s a list of players he’s older than: Romelu Lukaku, John Stones, Muhamed Besic, Gerard Deulofeu, Ross Barkley, Luke Garbutt and Steven Pienaar’s newest hip replacement. Away from Everton, there’s Raheem Sterling, Paul Pogba, Alex Oxlade-Chamberlain, half the Nigeria national side (so they’d have you believe), Marco Verratti and Julian Draxler. Mario Götze is only a couple of months older and he has scored the winner in a World Cup final, so the “wave of the future” hype has passed. He is however a sound lad and a decent player who has impressed in pre-season. Against Swindon. One player who is not attracting such plaudits is Arouna Koné – there aren’t many Evertonians who would get behind the Ivorian right now, unless they were doing so in order to shove him out the exit. His two uninspiring, albeit injury-hit years have yielded just one goal, which for an outlay of £6m is unacceptable. More than anything Koné’s failures have put Romelu Lukaku under serious pressure as the only recognised striker capable of scoring goals on a regular basis. We need another striker more than anything else, one that can provide consistent goals. But we’re Everton, so the curse would get him as it has got Koné in emphatic fashion. Add another one to your “Everton aren’t we” tally. But there are positives. There’s plenty of quality within the squad, and James McCarthy committing himself to the club for another five years is a sign that the players are backing the manager’s vision, or at least that we have the power to keep our best players. If John Stones and Kevin Mirallas can follow suit, we’re in business. Shall we get on with it then? Watford are first up, and hosting a newly promoted side at Goodison means we’ve either been handed the easiest possible start or the biggest possible banana skin. They haven’t got John Barnes or Luther Blissett, and in their two previous Premier League seasons they’ve finished bottom both times, so naturally you’d edge towards the former. But they’ve shaken things up this summer, with a new manager and ten new players, so there’s a real air of unpredictability. LIVERPOOL, UNITED KINGDOM – AUGUST 19: Andrew Johnson of Everton celebrates scoring the opening goal during the Barclays Premiership match between Everton and Watford at Goodison Park on August 19, 2006 in Liverpool, England. (Photo by Richard Heathcote/Getty Images) Ex-Atletico Madrid manager Quique Sanchez Flores has replaced Slavisa Jokanovic as boss at Vicarage Road, and becomes Watford’s fifth manager in the last year. Given that turnover rate, plus the pressures of the Premier League and the fact he is untried in English football, Sanchez Flores is in the firing line more than Bruce Forsyth in the next round of Operation Yewtree investigations. He has acted quickly and spent wisely to add real depth to the squad. Defenders Seb Prödl, José Holebas, Miguel Britos and Allan Nyom have all joined to bolster the back line. Nyom is another product of Watford’s Pozzo circle-jerk with Udinese and Granada: he joins from the Italians, but never played for them, having spent six years on loan with the Spanish side. Must be some sort of record. And you thought we were the loan masters. The “special connection” with Udinese, like one a mother may have with the thirteen year old child she’s breastfeeding (such is the early life of a Daily Mail reporter), also sees the handy Matej Vydra join on a permanent deal after a couple of loans. Etienne Capoue and Valon Behrami add some reliability to the midfield, while Jose Manuel Jurado is an attacking option. Steven Berghuis scored plenty in the Netherlands for AZ Alkmaar and could do well in England. If all the new signings gel, the Hornets could stage their best effort at staying in the Premier League. If not they’re going down faster than a double whiskey in Howard Kendall’s living room. That much is easy to predict. Those seven are nailed on to start every game if fit. Yes, I know. I see Howard and Barry in there too. But there are more pressing matters right now. In an ideal world, the attacking line-up is either Mirallas-Barkley-Deulofeu with Lukaku up top or NOT MCGEADY-NOT MCGEADY-NOT MCGEADY with NOT MCGEADY up front. Have I been too mean to Aiden McGeady today? Please send your complaints to www.hahahahaidontgiveafuckpal.com. Injuries mean we may have to shuffle, and although Mirallas may well start it could be with utility man Tom Cleverley on the left and Steven Naismith or Leon Osman in the middle. If Lukaku isn’t passed fit, it’s…still Lukaku. Don’t care. We’re not putting Koné up top. It’s potent and vulnerable at the same time. Like Achilles, although complaining of a case of a massively swollen Achilles heel with a bullseye painted on. But now’s the time for positivity. Well, you’ve got no other choice. You’ve sat down in this rollercoaster car and we’re about to set off. There’s no getting out now. It’s up to you to find out if you’ve gone to Alton Towers by mistake. But without a single game played this season, the possibilities are endless. We’re up for the league and up for the Cup. There’s a lot of drama to come, and amongst the fuming and failure there will be flashes of glory. Who knows how much we’ll get. So make your way up to the Promised Land, take your place, roar the Blues on. Feel the hairs on the back of your neck stand to attention as the first strands of Z-Cars resonates through your body and mind. And brace yourself.Electronic scanning structures may scan in two orthogonal directions; cylindrical or conical structures assuring scanning in the plane containing the axis of the structure. The present invention pertains to an electronic scanning method starting with a microwave beam emitted by a flat antenna, and to the applications of this method to the construction of structures permitting electronic scanning by a focused beam without dispersion caused by variations of the emitted frequency. We know that the microwaves employed in radar systems employing either mechanical or electronic scanning processes may generate plane waves. These plane waves can be produced for example by an optical focusing system of non-directional spherical waves emitted by horns or by simple dipoles. We well know the inconveniences of these systems, such as parabolic reflector or passive focusing lens, due to their bulkiness, their lack of manipulation, or difficulty in adjusting. There also exist systems emitting plane waves. These are flat antennas which can be made up of slotted wave guides, dipole stripline circuits or other forms of multifunction integrated circuits. These flat antennas are made up of a juxtaposition of single radiating elements in rows and columns; each of these single elements is not fed individually but each line of elements is fed at one end in order to reduce the number of feeders. These types of flat antennas are interesting in that they produce a focused plane wave without the addition of supplementary equipment. They possess however a well known but bothersome fault in that since these single elements which make up the flat antenna are fed in series at one end and not individually, the plane wave radiated by the flat antenna is not exactly parallel to the plane of the single elements; furthermore the direction angle this wave takes with respect to the perpendicular
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you to choose differently." His head dropped, his cheek coming to rest on my hair as his arms came around me. "Don't choose differently. Ever." "Then don't be a clodpate," I muttered, trembling with all the emotions surging through me. He paused. "Or a Miserable Blockhead?" I huffed an almost laugh. "Or that." "Forgive me." "All right." "Just like that?" "I'm a Fireblood. I'm allowed to be mercurial." He started to laugh, then groaned. "My ribs. I want to hold you, but everything hurts." "A good reminder for you." He chuckled softly, rubbing a hand over his chest. "You're a cruel woman." Before I could reply, the Minax whispered in my mind. _Cruel, yes._ "What's wrong?" Arcus asked, sensing my change in mood. I shook my head and forced a smile. # SEVENTEEN _B LACK SAILS AT DAWN. TEN SHIPS,_ _twenty, a hundred—spanning the horizon. A mix of Tempesian warships, Sudesian brigantines, and Safran galleons, hulls cleaving a bloodred sea._ _They all sailed under one flag: a white sun on a black background. Above each vessel, a contingent of winged shadows flew the skies._ _I floated above the masts, a wraith among wraiths. I felt no wind, no cold, only the swirl of emotions from the sailors below: eagerness, purpose, bloodlust, anticipation. Their tainted hearts churned for the next kill._ _We shades would weave into their blood, drive them to more violent acts, then reward them for their compliance by multiplying their human sensations into something heady, rich, irresistible. Divine. Once they experienced this potent inebriant, their mortal shells were never the same. They would always need the next victim, the next conquest, the next massacre._ _This dark bliss had already become their lifeblood, their reason for living._ _The sails bellied out, a laughing tailwind careening us toward our target. Ahead, the shore was thick with warriors ready to fight, defend, die. Their pikes and axes glinted red with the dawn._ _Clustered on the pebbled beaches, our prey held thoughts of love like talismans—warm thoughts of children, siblings, parents, spouses. Their families waited at home, praying for their victory._ _We held thoughts of death. Anticipation wound tight in the mortals' viscera. Elation filled us._ _Soon, the rapture of battle._ _When our small boats reached the shallows, our black-clad armies poured forth without hesitation._ _We, the shadows, were their shields._ _Before the first enemy archer could loose an arrow, or the first pikeman strike a blow, we sped to the waiting army. Reaving minds, we took over their thoughts and intentions. They dropped their shields, turned on one another, sliced throats, stabbed into gaps in armor—the soft flesh of thighs, under arms, necks—those vulnerable, unprotected spaces where blood pumped hot or cold._ _Whether Frostblood or Fireblood, we distinguished not. Death in all forms pleased us. Fed us._ _The shadows danced among the dying._ _I soaked up every scream, every cry, every last wish, drawing out the agony as long as possible to savor each slow, rattling gasp. With whispered words, I slowed hearts, tightened veins, restricted the flow of blood to prolong those last precious moments, binding the spirit to the body for as long as I could._ _And just when the once-proud warriors finally thought to escape this suffering and find peace, I cracked open their minds to tease forward each regret, each memory of shame, of hatred, of fear, of defeat, making their last moments torturous. I drew out their suffering with ravenous glee—like sucking the flesh of an oyster from its shell._ _A few, we saved. Those with darkest thoughts, greatest rage, deepest hatred. Strong bodies with weak minds. We broke the spine of their identities and remade them new. Recruited them to our cause._ _In this way, each battle swelled our ranks._ _Finally, we slipped from the dead to the living, from conquered to conquerors. We entered their hearts and pulsed in the space between heartbeats, sharing our pleasure, making them crazed with it._ _When it was done, bodies coated the beach, the faces of the dead contorted with their final moments of pain._ _Our warriors stood panting, eyes wild with ecstasy, black tunics soaked with blood, hearts full of death._ _Already, we planned the next slaughter._ _Death was life._ _And we, the shadows, hungered._ I woke gasping, hands flailing. A scream echoed in my ears. The euphoria of battle pulsed in my veins—pleasure derived from other people's suffering. My stomach roiled. With a fiery fingertip, I lit a candle on the bedside table. Red-and-gold bed hangings fell at the corners of the four-poster bed. Soft light poured over the bookshelf and the upholstered chair by the darkened window. A wide-eyed face peered back at me from the wavy glass. I started, then realized it was my reflection. I remembered where I was—in my room in the castle. It was the last night before we set off on our voyage. A knock sounded. "Ruby?" I slid out of bed and padded to the door. As soon as I opened it, Arcus entered with a cold gust of air. "I heard you scream," he said in a sleep-roughened voice. His hair was ruffled, shirt undone, feet bare. I blinked in confusion. I'd screamed? "You could hear me?" He stepped closer, looking at me with concern. "Our rooms share a wall. Were you dreaming again?" I rubbed my arms, still shivering with reaction. I couldn't get warm. "Here, get under the covers." He moved to pull back the quilt. I crawled into bed and he tucked the blanket around me. "What happened?" he asked softly, the bed depressing with his weight as he sat on the edge. I leaned on him, resting my cheek against his shoulder, needing his contact more than I needed warmth. "A battle." My throat felt tight, every word an ache. He smoothed a hand over my hair. "Against whom?" I stiffened. The warriors in the dream had been Frostbloods. His own army. I didn't want to tell him that I'd imagined killing them, that I'd reveled in their pain. What kind of sick mind did I have to dream such things? I still felt a deep conviction that the Gate wasn't open. If it were, the Minax in my heart would feel it, and I would know it. So the dream hadn't been a scene from the present... but it could have been a vision of the future. The future Eurus was planning. "Ruby, what's wrong? I can see you're upset. Talk to me." After a minute, his hand tightened on my quilt-covered knee. "Tell me something. _Anything._ " His worry pulled at me. Still, I couldn't bring myself to tell him what I'd done in the dream. "I feel like"—I opened my palms, struggling to put it into words—"if I tell you, I'll pull you into this web... this web I'm caught in. And then you'll be caught, too." _And you'll see how twisted I've become and you'll never want to come near me again._ My throat closed and my eyes pricked with tears. I turned to blink them away. My heart felt empty. I checked for the Minax. I couldn't feel it. Where was it? _Had it left me?_ Panicked, I grabbed Arcus's face, tilting it down so I could search his eyes. My hands burned from the cold of his skin. I could feel my thumbs digging into his cheeks, but I couldn't gentle my touch. "Ruby!" His large hands covered mine. "For Tempus's sake! What's wrong?" My breathing hissed in and out like a ragged wind. _The east wind laughed as it sped us toward the battle._ I shook away the memory. His eyes were the same icy color as always. I pushed his cuff from his wrist and checked the vein. Frostblood blue. No sign of the Minax. I sat back, shoulders slumping with relief. He slid a palm to my cheek, turning my face and scrutinizing me. "I don't understand. What is this web you're talking about? What has you so scared?" How could I tell him that despite my expressions of confidence, I was no longer sure whose will was stronger, the Minax's or mine? I'd told myself I was in
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was admitted to the practice of law in Colorado in 1961. The hearing board resolved most of the charges against the respondent on cross motions for summary judgment filed by the complainant and the respondent. The hearing concerned the one remaining disciplinary charge, whether the respondent had violated Colo. RPC 1.7(b), and the appropriate disciplinary sanction. The following issues were determined on the motions for summary judgment based on the parties' agreement of undisputed facts. On September 27, 1983, C. Ray Page purchased a cabin located on United States Forest Service land. The Forest Service granted Page a special use permit allowing him to keep the cabin on government property. Page conveyed the cabin, but not the permit, to the C. Ray Page Living Trust (later called the Page Children Living Trust) in 1985. On December 14, 1992, the trust conveyed the cabin to Thomas C. Ledbetter, Page's business partner. Page continued to hold the special use permit. Also in December 1992, Page and Ledbetter obtained a loan from the Castle Rock Bank in the amount of $24,400. The consumer loan agreement was signed on December 29, 1992. The loan was secured by a security agreement granting the bank a security interest in the cabin (which was considered personalty) and the special use permit. The loan was in default in March 1993, and there were ongoing discussions between Ledbetter and the bank regarding the delinquencies. During the same time period, Page and Ledbetter began to disagree and each hired his own lawyer. Page retained the respondent with whom he had been dealing for a long time. In April 1993, Page and Ledbetter, and their respective lawyers, met to discuss repayment of the loan. The participants did not review any loan documents or discuss the cabin or the permit at the meeting, however. In July 1993, Page owed the respondent about $50,000 in legal fees for work performed previously. Page offered to transfer the cabin to the respondent to settle the past due legal fees and the respondent accepted the offer. On July 1, 1993, the cabin and the special use permit were transferred to the respondent. The respondent and his client filed a request with the Forest Service to transfer the cabin to the respondent, and on July 28, 1993, a bill of sale was recorded, transferring it to the respondent. The bank filed a verified complaint on the promissory and seeking replevin, in the Douglas County District Court on August 12, 1993. The complaint alleged that Page and *135 Ledbetter had given the bank a security interest in the cabin. According to the respondent this was the first time he learned that the bank had a security interest in the cabin which Page had purportedly transferred to him. The respondent filed an answer to the complaint on behalf of Page on October 6, 1993, and a cross-claim against Ledbetter. The answer asserted that the bank did not have a lien on the property as claimed in the complaint, which included the cabin. In his answer to the complaint and cross-claim and his own cross-claim against Page, Ledbetter stated that Page had transferred Page's interest in the cabin to him as an inducement and security for the purpose of obtaining a loan and personal guarantee. The respondent filed an answer on Page's behalf to Ledbetter's cross-claim on November 4, 1993. The respondent's answer denied the specific allegations that: (1) Page had represented to Ledbetter that he had an interest in the cabin; (2) the personal property, including the cabin, would be available to secure the loan; and (3) Page would transfer the cabin to Ledbetter for the purpose of obtaining the loan. Moreover, the respondent specifically denied paragraph 27 of Ledbetter's cross-claim, which stated: "Subsequent to the Defendant's [Ledbetter's] execution of loan agreements and security agreements, the Defendant, C. Ray Page, has transferred by National Forest Service Forms his interest in the special use permit to some third party." The respondent signed this answer to the cross-claim even though he believed that Page had previously transferred his interest in the cabin and special use permit to the respondent. Between August 1993 and February 1994, the respondent never disclosed to the district court or the bank's lawyer the respondent's interest in the cabin. On February 16, 1994, following a trial, the district court concluded that the bank had a valid security interest in the cabin granted to it by Page and Ledbetter. The court therefore ordered the defendants (including Page who continued to be represented by the respondent) to surrender possession of the cabin forthwith to the bank. The respondent still had not told the district court that he claimed an interest in the cabin. The counsel for the bank requested the Forest Service to transfer the cabin to the bank pursuant to the district court's order. On March 8, 1994, the respondent sent a letter to the Forest Service which objected to transferring the cabin to the bank because the cabin was titled in the respondent's name. The Forest Service then informed the bank that the cabin could not be transferred to the bank because of the respondent's interest in it. The bank subsequently filed a motion to amend its complaint to add the respondent as a party and to add claims of fraud and fraudulent conveyance. The respondent objected, stating that the action was concluded by the court's judgment against the defendants. Nevertheless, the court permitted the bank to amend the complaint, and the respondent and Page each obtained separate counsel to represent them. The hearing board determined that the foregoing facts demonstrated that the respondent violated Colo. RPC 1.8(j), which states: (j) A lawyer shall not acquire a proprietary interest in the cause of action or subject matter of litigation the lawyer is conducting for a client, except that the lawyer may: (1) acquire a lien granted by law to secure the lawyer's fee or expenses; and (2) contract with a client for a reasonable contingent fee in a civil case. The respondent argues that the purpose and scope of Colo. RPC 1.8(j), which is the same as former DR 5-103(A), is to deter common law champerty and maintenance, and, since the respondent's interest in the cabin was not the result of champerty or maintenance, the respondent could not have violated the rule. We disagree. The comment concerning Colo. RPC 1.8(j) provides: Paragraph (j) states the traditional general rule that lawyers are prohibited from acquiring a proprietary interest in litigation. This general rule, which has its basis *136 in common law champerty and maintenance, is subject to specific exceptions developed in decisional law and continued in these Rules, such as the exception for reasonable contingent fees set forth in Rule 1.5 and the exception for certain advances of the costs of litigation set forth in paragraph (e). (Emphasis added.) While this rule has its basis in the common law, the scope of the rule has not been limited to conduct which would constitute champerty and maintenance. See People v. Franco, 698 P.2d 230, 231-32 (Colo.1985) (lawyer's obtaining interest in real property in excess of his client's equity in the property, and therefore constituting an interest in property subject to dispute, violated DR 5-103(A)). There is no question that the respondent's interest in the cabin was literally "a proprietary interest in the cause of action or subject matter of litigation the lawyer is conducting for a client." Courts in other jurisdictions have enforced the literal language of the rule against acquiring a proprietary interest in the subject of litigation, despite the absence of champerty or maintenance. See, e.g., State ex rel. Neb. State Bar Ass'n v. Thor, 237 Neb. 734, 467 N.W.2d 666, 674 (1991) (lawyer representing Chapter 7 debtors violated DR 5-103(A) by purchasing clients' property after abandonment by trustee while abandonment remains subjection to objection by creditors); Office of Disciplinary Counsel v. Baldwin, 74 Ohio St.3d 592, 660 N.E.2d 1145, 1146 (1996) (purchasing client's property at public auction without informing client of purchase violated DR 5-103(A)); State ex rel. Okla. Bar Ass'n v. English, 853 P.2d 173, 174-75 (Okla.1993) (by secretly purchasing creditor's claim, lawyer for creditors' committee in bankruptcy case violated DR 5-103(A)). In Louisiana State Bar Ass'n v. Sanders, 568 So.2d 1025, 1028 (La.1990), the court suspended a lawyer for acquiring an interest in a client's property that became the subject of litigation. Particularly relevant to this case, the Louisiana Supreme Court held that "DR 5-103(A) forbids an attorney from acquiring any right `which is genuinely disputed and likely to become the subject of litigation.'" 568 So.2d at 1028 (quoting Succession of Cloud, 530 So.2d 1146, 1150 (La.1988)). Furthermore, the prohibition in the disciplinary rule [DR 5-103(A)] does not apply only when there is a pending lawsuit. When the client consults the lawyer about a right which is genuinely disputed and likely to become the subject of litigation, and the attorney agrees to pursue the claim, the prohibition applies. Otherwise, there would be too much potential for abuse by the attorney who has substantial control over the filing or the answering of a suit. Succession of Cloud, 530 So.2d at 1150. This reasoning applies directly to the facts of this case. When the respondent acquired his interest in the cabin, the ownership of the cabin was "genuinely disputed and likely to become the subject of litigation." We agree with the hearing board that the respondent violated Colo. RPC 1.8(j) by acquiring an interest in the
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:23: note: expanded from: #define __DARWIN_NULL ((void *)0) ^~~~~~~~~~~ test.c:17:43: warning: incompatible pointer to integer conversion initializing 'char' with an expression of type 'void *'; "1.2", { "clop", "clop", "stamp", NULL } ^~~~ /usr/include/stdio.h:82:14: note: expanded from: #define NULL __DARWIN_NULL ^ /usr/include/sys/_types.h:91:23: note: expanded from: #define __DARWIN_NULL ((void *)0) ^~~~~~~~~~~ test.c:17:43: warning: suggest braces around initialization of subobject [-Wmissing-braces] "1.2", { "clop", "clop", "stamp", NULL } ^~~~ /usr/include/stdio.h:82:14: note: expanded from: #define NULL __DARWIN_NULL ^ /usr/include/sys/_types.h:91:23: note: expanded from: #define __DARWIN_NULL ((void *)0) ^~~~~~~~~~~ 4 warnings generated. A: While the macro NULL is intended (at least, was by those who first defined it) to be used exclusively as a pointer value, it's often #defined with a simple: #define NULL 0 This is probably the case for your implementation (not that it matters here, except for illustration; it could be defined as (void *)0 without changing the results below—but this would result in a compile-time complaint about your initializers). Let's expand that first for loop with the above in mind: for (i = 0; (asdf.description)[i] != 0; i++) { printf( "\t%s\n", (asdf.description)[i]); } (Side note: The parentheses here are not needed as the binding of the . and subscript operators is already the one forced by the parentheses.) Each asdf.description[i] names one entire array (of size DESCRIPTION_LEN) of char. You are therefore comparing: <some array of char> != 0 The "value" of an array object is a pointer to the array's first element, so this has the same meaning as: &asdf.description[i][0] != 0 Comparison of a pointer value (&asdf.description[i][0]) to the integer constant zero tests whether the pointer is NULL (not "the macro NULL but rather "the system's internal representation of a NULL pointer"). The address of a valid pointer never compares equal to 0, so the loop runs (in effect) "forever" (certainly until i >= 32). Eventually, the call to printf passes a pointer value that results in the segmentation fault you see. Presumably what you really meant to do was to initialize the array following the last valid one with all-zero-byte chars (or at least an initial zero byte). In that case, the loop test should read: asdf.description[i][0] != '\0' You might also consider the possibility that the 32-element array (of arrays of DESCRIPTION_LEN of char) is completely filled with valid arrays-of-char. In this case, you should check the value of i before looking at asdf.description[i][anything]: i < MAX_DESCRIPTION_COUNT && asdf.description[i][0] != '\0' There was fear this week – real fear. There was fear eliminating $2.5tn from the value of global shares in a mere five days. There was fear provoking the dumping of Italian government bonds at rock-bottom prices. And there was fear taking the yield on short-dated US treasury bills to below zero: investors were so anxious to park their cash somewhere safe that they were, in effect, paying the US government money to steward their savings – something not seen since the second world war. Yet the credit ratings agency Standard & Poor's ended the week by casting a shadow over the creditworthiness of American government debt, unprecedentedly downgrading it from its AAA status, a monumental blow to the standing of the richest country on Earth and its political system. S&P's held its ground despite intense lobbying from the US treasury. Without tax increases, it said, the US could never recover its fiscal position – but tax increases, given the implacable opposition of congressional Republicans, have become impossible. The markets lurched downward. Meanwhile in Europe, France's president, Nicolas Sarkozy, chair of the G20, finally managed to disturb German chancellor Angela Merkel's holiday and, with Spain's prime minister José Zapatero, discussed in a conference call how best to react. It was long overdue. Even the president of the European Commission, José Manuel Barroso, described a week in which individual governors of the European Central Bank, and the German government, were openly saying different things about whether the ECB would support the Italian and Spanish stricken bond markets as "undisciplined communication". The ECB said it was "constructive ambiguity". To panicking markets, it looked what it was: hesitation and indecision that could only fan the flames. What we have witnessed is a mass global flight from risk and an accompanying hoarding of cash on a huge scale. It was the worst week in the financial markets since the dark days of autumn 2008 at the height of the implosion of the western banking system – itself one of the worst periods since the early 1930s. But in important respects this week was worse. At least in 2008, governments could put their national balance sheets behind their respective banking systems to restore confidence. Now the fears are more deep-seated and far harder to counter. The markets have lost confidence that western governments can successfully manage the legacy of vast private debt and broken-backed banks without imposing huge and nameless costs. They don't know what the costs will be – perhaps a series of chain defaults on government debt starting in Europe, perhaps worldwide debt deflation, or even helplessly printing money to pay off public and private debts, so generating unmanaged and volatile inflation. But they know the costs will be huge. And unpredictable. After all, Greece's eurozone creditors, who were part of the EU deal two weeks ago, accepted that Greece might not be able to pay its public debts in full. What about other countries in the eurozone, such as Italy and Spain, with even bigger public debts? Will their creditors be similarly hammered if the contagion spreads? And if individuals, companies and governments have collectively got too much debt that they cannot repay, whether inside or outside the euro, what prospects for the banks – and indeed any of their creditors – who lent the money? What is the extent of their writedowns or even potential bankruptcy? The markets have known these truths for some months but have trusted that policymakers in Europe and the US also knew the risks and also how to respond. In any case, it was hoped, global growth and the steady rebuilding of western banks' balance sheets would gradually allow the world to lower its massive debts and banks to remain solvent. But events of the past few weeks have shaken that faith to the core. The scale of the economic challenges that the western industrialised countries now confront may be impossible to handle. The markets' judgments are brutal. For example, this week yields on American 10-year treasury bonds fell to levels – 2.2% – that only make sense in a world close to falling prices and economic stagnation. Meanwhile, the yield on Italian government debt rose at one time on Friday to 6.4%, meaning that the government would have to plan for vast and deflationary budget surpluses for years just to service its debts worth more than 120% of its GDP. On Friday evening, prime minister Silvio Berlusconi bowed to the inevitable and promised to balance the Italian budget a year earlier than his government had planned only a fortnight ago. "No major advanced economy is doing anything to promote growth and jobs," says George Magnus, a senior policy adviser to investment bank UBS. He is right. Wherever you look, it is an economic horror story. Put bluntly, too many key countries – the UK in the forefront, with private debt an amazing three and half times its GDP, but followed by Japan, Spain, France, Italy, the US and even supposedly saint-like Germany – have accumulated too much private debt that cannot be repaid unless there is exceptional global growth. That looks ever more improbable. Yet without growth there are only three ways out. The first is to increase public borrowing to compensate for the collapse of private borrowing. Private spending is bound to be depressed as individuals and companies lower their borrowing – so for a time exports (as long as other countries are buying) and growing public debts are the only reliable avenue to promote economic growth. But now there is a veto on growing public debt – due to the Tea Party movement in the US, the collapse in confidence in the euro and Britain's conservative government – and export demand from Asia is slowing. The lessons from history are clear. Without publicly or privately generated growth there are only two other ways forward to pay down private debt after credit crunches: default or inflation, either containably managed or dangerously unmanaged. What has unnerved the financial markets is that if the world cannot grow we
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ma had three children with the help of the community doctor, grandpa decided the doctor was a waste. He, himself, would deliver the babies. Four, five and six were no problem. Number seven, Olivia's dad, was premature. Even when it was abundantly clear that things weren't going well, grandpa brought the baby into the world, took the cradle near the fireplace to warm up the little guy, patted grandma on the arm, told her to rest and left the room. Olivia's uncles told Olivia's father that they had heard their mother screaming, and then whimpering, and finally, moaning. Eventually everything was still. Their father forbade them from entering the room. In the morning, when grandpa went back into the bedroom with the squalling baby, grandma lay still and stiff. He called the boys in to say goodbye to their mother and then sent them out to dig a grave. Grandpa reportedly tried diligently to find a replacement mom for this mob, but no one was willing to take on seven stepsons, including a scrawny, undernourished baby, much less take on grandpa, whose reputation had preceded him all over town. Olivia learned all this from a father who bragged about it, almost revering his father when he was sober, and cried about it with fathomless self-pity when he was drunk. From this beginning, Olivia's dad came into adulthood a belligerent, angry, raging man. A stint in the Army didn't soften him any. He became a long-distance truck driver whose company demanded that he unload the trucks himself. This added a violent twist to his behavior as he frequently treated the children with as much brutality as he treated the boxes he was unloading from his trucks. Olivia, like him the littlest and lightest, went farther across the room and was hurt the most when he hurled and heaved the children around. Her two older siblings left home as soon as they possibly could. Neither graduated from high school. Her older sister got pregnant and then got married and then got out of the house. Her older brother falsified papers somehow and got himself into the Navy. He became a submarine mechanic. In a rare moment of vulnerability with Olivia, he explained to her that he felt safe on a submarine. Their absconding left Olivia, at the age of nine, alone with an un-empowered mother and a cruel, controlling, abusive father. Olivia calls her troubling childhood memories "Kodak moments." She has flashes that don't make much sense to her, but she sees each flash in her mind with the clarity of a photograph. She is crawling silently beside the sofa where her father is sleeping and his hand juts out and slaps her in the head. She is riding in the backseat of a car which her father is driving fast and erratically, knocking over trash cans and sideswiping mailboxes, when a woman's gloved hand comes over the front seat and pushes Olivia down on the floor in the back and holds her there. Now, as an adult, she knows it was her mother's hand trying to protect her from what she must have felt was an imminent accident. She has a clouded image of an oriental woman smiling at her as her father introduces them. She remembers getting into the car ostensibly to go get ice cream and ending up at the hospital to get her tonsils out instead. She has a memory of a doctor with bushy eyebrows and a mask and wonders if this is connected to the tonsillectomy. She has another ice cream memory. They are driving to get ice cream, she and her parents and the two older ones, and her mom says something to her dad, she can't hear what, and her dad slams on the brakes and turns around and without explanation drops everyone off at home and keeps going himself. These Kodak moments come without warning, flash in front of her mind, and drive her to distraction. "What is all this stuff?" she wants to know. "What does it mean? Why won't it stop? What can I do? See, I'm crazy." Olivia has an album of memories which haunt her days and shatter her sleep. One of the most upsetting happened when, she believes, she was eleven. Her father and mother had one of their many unbalanced fights. Her dad was more angry than usual and beat her mother with his fists. Olivia was in the house while this was happening, but her parents were in the bathroom and the door was locked. Her father finally flung open the door and flew down the steps and out of the house. She found her mother unconscious in the bathroom. She remembers dragging her into the bedroom and somehow getting her into bed. Had her mother not been moaning, she would have believed her to be dead. Olivia cleaned her up and nursed her as well as any eleven year old could, and then she spent the night sitting behind the front door with a large butcher knife in her hands. He was not going to hurt her mother again. The fighting was so bad that whenever possible her older sister would come and get her and take her to her house for the weekend. Olivia had a room to herself at her sister's house. She would frequently wake up to find her brother-in-law standing silently in the room, and when she would say something, he would say he was just checking on her and walk away. Then one night she awakened to his hands rubbing her legs and removing her panties. She screamed and ran the mile home in her pajamas and bare feet in the middle of the night. Despite the fact that she told her story with outrage, the family version of that night was that Olivia had had a bad dream and, in her usual, super sensitive, overly reactive way, made a mountain out of a molehill. Nothing had taken place. This happens all too frequently to PTSD child victims. They are not believed. Insult is added to injury. Finally her parents divorced and Olivia and her mother lived on scant child support but the joy of no violence and no fear. The abuse had taken a toll on her mother, though, and her incredibly mistreated and abused body was no match for the cancer that came. Olivia nursed her for the three years that it took the cancer to kill her. By this time Olivia was just graduating from high school and so, with her options an abusive father's house, her sister's house where her brother-in-law was free to molest her, or a stowaway on the submarines with her brother, Olivia chose her life path. Having completed a medical technology class in the vocational high school she attended, she took the first full-time job that was offered, in an obstetrician's office, and found herself the cheapest apartment in town. She was never to escape the cycle of poverty known as the working poor. Olivia married once. Her husband was so respectful that he told her he wanted to wait until after they were married to have sex. He was a musician and he was temporarily between gigs. He didn't have a violent bone in his body. She dragged him with her to meet me. Neither of us imagined that he was gay. Three years later, with an unconsummated marriage and a couple thousand dollars of extra debt, she asked him to leave and the marriage was over. It had been a non-violent relationship and an affectionate one. Had Olivia not been so impeccably honest, she might have been able to tolerate the fraudulent nature of the non-marriage. Single ever since, Olivia has gone through periods of great emotional contentment and periods of horrendous upheaval and loneliness. As her symptoms materialized, we tried to handle them. Her Signs Anxiety was and has always been Olivia's primary and most disruptive symptom. It was anxiety, in fact, which proved to be the tipping point which brought Olivia into counseling. It is just so very hard for her to ever feel safe or relaxed. Her early childhood of pain has so tightened and constricted her body and her mind that she is a chronic jangle of nerves and tension. If she has something to worry about, she obsesses about it. If she has nothing to worry about, she worries that she's missed something and she becomes more hyper-vigilant and wired. She describes in her own written words what happens to her and how unexpectedly it happens: I went to have breakfast with a friend. We sat and ate and talked about nothing in particular. I said, "I must have had too much coffee. I feel jittery." When we were standing in the parking lot saying good-bye, I could feel a "rush" through my entire body. My throat became very tight, felt swollen, my hands were shaking, my legs shaky. When I got in the car, I felt weak, sweaty, and nervous. Driving home I began to feel fearful, then scared to the point of crying. I stopped to get cigarettes. As I reached for the door of the store, there was another "rush." I couldn't help thinking, "Why are you afraid of a door?" Then it occurred to me to try something. When I stood in line, I stayed still, touched nothing. Bam. Another "rush." Panic, fear, shaking. However, I realized that my "rushes" occurred on their own. Doors do not trigger them. Lines of people do not trigger them. I came home, went to the bathroom, felt faint, then laid across my bed. My thinking was confused, fragmented. Bits and pieces of conversation popping in and out of my head. One-liners, so to
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.com; Salita Mella 13; pizza €10, meals €40-45; hnoon-2.30pm & 7-10.30pm) The intimate terrace just above a crossroads of laneways in Bellagio's old town is a fine place for a meal. The restaurant has been around since 1887, which is plenty of time to perfect dishes such as deboned white lake fish in a pistachio crust or guinea fowl with whisky and mushroom sauce. Bar RossiBAR ( GOOGLE MAP ) ; %031 95 01 96; Piazza Mazzini 22; snacks €3-8; h7.30am-midnight Apr-Sep, to 10.30pm Oct-Mar) All gleaming walnut wood, glinting mirrors and regiments of bottles, the art nouveau Bar Rossi is one cafe not to miss. Revel in the elegant interior or take a seat outside under the arches and watch the ferries come and go. 7Shopping Caligari AlimentariaFOOD (Via Bellosio 1; h8.15am-1pm & 4-7pm Tue-Sat) The smells wafting out from this deli will surely tempt you to step inside. Among the piled-high Larian goodies are dried porcini mushrooms (€7.50 per 50g), DOP Laghi Lombardi-Lario olive oil and _missoltini_. 8Information PromoBellagioTOURIST INFORMATION ( GOOGLE MAP ) ; %031 95 15 55; www.bellagiolakecomo.com; Piazza della Chiesa 14; h9.30am-1pm Mon, 9-11am & 1.30-3.30pm Tue-Sun Apr-Oct) A consortium of local businesses that provides useful information. Tourist OfficeTOURIST INFORMATION ( %031 95 02 04; [email protected]; Piazza Mazzini; h9am-12.30pm & 1-6pm Mon-Sat, 10am-2pm Sun summer, reduced hours winter) The official tourist office, next to the boat landing stage. Can provide information on water sports, mountain biking and other activities. ### CLOONEY'S COMO Long the playground of the fabulously wealthy, Como's most famous current resident is Hollywood legend George Clooney. Here are our tips for sampling the film-star lifestyle, and for doing Lago di Como – Clooney-style. **Laglio** Wander the lanes of this hamlet, 7km north of Cernobbio; George's pad is waterfront Villa Oleandra. Harry's Bar Slug back a cocktail at this A-listers' local in Cernobbio. Motorbike tours Get around the way George does, amid Como's hills. Barindelli's Book a cigarette boat for a cinematic trip. Villa d'Este and Gatto Nero Drop by for dinner, and dine with the stars. #### Cernobbio to Lenno The sunny, western lake-front stretch from Cernobbio to Lenno is one of Lago di Como's most glamorous. The big draws here are the blockbuster villas; some are open to the public (such as the bewitching Villa Balbianello); some are most definitely closed (including George Clooney's place, Villa Oleandra, in Laglio). 1Sights oVilla BalbianelloVILLA, GARDENS ( GOOGLE MAP ) ; %0344 5 61 10; www.fondoambiente.it; Via Comoedia 5, Località Balbianello; villa & gardens adult/reduced €15/7 gardens only adult/reduced €8/3; hgardens 10am-6pm Tue & Thu-Sun mid-Mar–mid-Nov) A 1km walk along the lake shore from Lenno's main square, Villa Balbianello has cinematic pedigree: this was where scenes from _Star Wars Episode II_ and the 2006 James Bond remake of _Casino Royale_ were shot. The reason? It is one of the most dramatic locations anywhere on Lago di Como, providing a genuinely stunning marriage of architecture and lake views. Built by Cardinal Angelo Durini in 1787, Villa Balbianello was used for a while by Allied commanders at the tail end of WWII. The sculpted gardens, which seem to drip off the high promontory like sauce off a melting gelato cone, are the perfect place for hopelessly romantic elopers to spend a day. Visitors are only allowed to walk the 1km path (amid vegetation so florid as to seem Southeast Asian) from the Lenno landing stage to the estate on Tuesdays and at weekends. On other days, you have to take a taxi boat ( %349 2290952; www.taxiboatlecco.com; return €7) from Lenno. If you want to see inside the villa, you must join a guided tour (generally conducted in Italian) by 4.15pm. 4Sleeping Villa d'EsteHISTORIC HOTEL€€€ ( %031 34 81; www.villadeste.it; Via Regina 40, Cernobbio; d €970-1140, ste €1530-1780; p a i W s) Much of Lago di Como draws the rich and glamorous; this hotel draws the richest and most glamorous of the lot. The 16th-century palace is beyond luxury: rich brocades drape beside marble bathrooms; balconies are bigger than some hotel rooms; fountains burble beside statues gazing onto exquisite lake views. George Clooney has been known to drop by for dinner, too. Relais Regina TeodolindaLUXURY HOTEL€€€ ( %031 40 00 31; www.villareginateodolinda.com; Via Vecchia Regina 58, Laglio; r €200-550; hMar-Oct; p a i W s) For a taste of the A-lister lifestyle, head for this sumptuous villa, slightly north of the village of Laglio (sometime residence of one Mr and Mrs Clooney). Elegant and deliciously tasteful rooms, many with lake views, emit refined sophistication; the welcome is discretion itself. Approach by the lake road or by boat via the private landing stage; you'll pass through delightful gardens either way. 5Eating & Drinking oGatto NeroMODERN ITALIAN€€€ ( GOOGLE MAP ) ; %031 51 20 42; www.ristorantegattonero.com; Via Monte Santo 69, Rovenna; meals €42-75; hnoon-2pm & 7.30-10pm Wed-Sun, 7.30-10pm Tue) The jet set loves this eatery high above Cernobbio, and for good reason. Book a front-row table and you'll have unobstructed views of the lake stretching out far below. Inside, dark-tile floors, plenty of timber and low lighting continue the romantic theme. The food meanwhile is strictly modern Italian, well presented and packed with flavour. Harry's BarBAR ( GOOGLE MAP ) ; Piazza Risorgimento 2; h10am-midnight) The real appeal of this lively bar in the centre of Cernobbio is the lake view from the verandah and the possibility that some of Como's Hollywood crowd might drop in for a drink (they often do, apparently). #### Tremezzo Pop 1240 Tremezzo draws fleets of ferries thanks to its 17th-century Villa Carlotta and spectacular Lago di Como views. 1Sights Villa CarlottaVILLA, GARDENS ( GOOGLE MAP ) ; %034 44 04 05; www.villacarlotta.it; Via Regina 2; adult/reduced €9/7; h9am-7.30pm Apr–mid-Oct) Waterfront Villa Carlotta sits high on Como's must-visit list. The botanic gardens are filled with colour from orange trees interlaced with pergolas, while some of Europe's finest rhododendrons, azaleas and camellias bloom. The 17th-century villa, strung with paintings, sculptures (some by Antonio Canova) and tapestries, takes its name from the Prussian princess who was given the place in 1847 as a wedding present from her mother. Upstairs, rooms with period furniture provide an irresistible insight into the royal lifestyle. You too can swan from the Salotto Impero (Empire Room) to Carlotta's bedroom and wonder just what it must have been like to hit the hay after a hard day at the lake. Villa Carlotta is a short walk southwest of the Cadenabbia car ferry stop. Villa Carlotta; this 17th-century waterfront villa and its gardens is a must-see for any visitor to Lago di ComoFrancesco Iacobelli
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the State's reliance on that cause any of you any problems in listening to his testimony, and listening—and weighing it as you weigh all the testimony? (Emphasis added.) The defendant contends the use of the phrase "truthful testimony" constitutes an impermissible personal voucher of the truthfulness of Mr. McMillian. The defendant relies upon United States v. Smith, 962 F.2d 923 (9th Cir.1992), as the authority for his position. In Smith, the circumstances surrounding the questioned argument were much more egregious. The prosecutor's closing argument in Smith included repeated personal assurances to the jury through direct comment and by inference that the testimony of a crucial witness was true. The court held that "[t]he prosecutor's recurrent harping on the issue of his special role was clearly improper. The repeated comments also demonstrate that the errors were not inadvertent." Id. at 935. We do not find Smith applicable to the instant case. Here, the prosecutor made a single comment which contained a direct quote from the language of the plea agreement. We do not believe the prosecuting attorney by doing so made a personal endorsement of the truthfulness of Ray McMillian. This was left to the jury. This assignment of error is overruled. The defendant next assigns as error in his capital trial the trial court's conducting of six unrecorded bench conferences not attended by the defendant. The defendant did not object at trial. Of the six challenged conferences, a review of the record indicates that three were held at the request of the defendant's counsel, two at the court's request not in response to any objection, and one at the court's request in response to an objection by the State. Counsel for the defendant were present at all conferences. The defendant contends that State v. Callahan, 83 N.C.App. 323, 350 S.E.2d 128 (1986), disc. rev. denied, 319 N.C. 225, 353 S.E.2d 409 (1987), is controlling. We do not agree. In Callahan, the Court of Appeals held that the trial court erred in failing to record the questions and answers in the court's inquiry as to the defendant's understanding of his rights pertaining to proceeding pro se. There can be no doubt that such an inquiry necessarily involves the defendant's constitutional rights and therefore must be recorded. We do not find that the conferences at issue in this case rise to the same level. Questions involving the defendant's unwaivable state constitutional right in capital cases to be present and to have all bench conferences recorded arise frequently. In State v. Buchanan, 330 N.C. 202, 410 S.E.2d 832 (1991), we reviewed the issue extensively. In Buchanan, this Court concluded: Though defendant himself did not attend the conferences in this case, we conclude that the trial court's bench conferences *798 with defense counsel and counsel for the State did not violate defendant's state constitutional right to be present at all stages of his trial. As stated above, defendant was personally present in the courtroom during the conferences. Further, and perhaps more importantly, his actual presence was not negated by the trial court's actions. At each of the conferences defendant was represented by his attorneys. Defendant was able to observe the context of each conference and inquire of his attorneys at any time regarding its substance. Through his attorneys defendant had constructive knowledge of all that transpired. Following the conferences defense counsel had the opportunity and the responsibility to raise for the record any matters to which defendant took exception. At all times defendant had a first-hand source of information as to the matters discussed during a conference. It also is relevant that bench conferences typically concern legal matters with which an accused is likely unfamiliar and incapable of rendering meaningful assistance. Other conferences typically deal with administrative matters that are nonprejudicial to the fairness of defendant's trial. In addition, such conferences do not diminish the public interest associated with defendant's right to presence. Unlike the excusal of prospective jurors following ex parte communications, in this case defendant, through his attorneys, had every opportunity to inform the court of his position and to contest any action the court might have taken. Id. at 223, 410 S.E.2d at 844-45; see State v. Upchurch, 332 N.C. 439, 455, 421 S.E.2d 577, 586 (1992). In Upchurch, we found the fact that the defendant's own counsel requested several unrecorded conferences to be significant. State v. Upchurch, 332 N.C. at 456, 421 S.E.2d at 587. Recently, we reiterated our holding in Buchanan, stating that "[t]he burden is on the defendant to show the usefulness of his presence at the unrecorded bench conference." State v. Lee, 335 N.C. 244, 264, 439 S.E.2d 547, 557 (citing State v. Buchanan, 330 N.C. at 223-24, 410 S.E.2d at 845), cert. denied, ___ U.S. ___, 115 S.Ct. 239, 130 L.Ed.2d 162, reh'g denied, ___ U.S. ___, 115 S.Ct. 624, 130 L.Ed.2d 532 (1994). In the instant case, the defendant contends the failure to involve him in the conference held at the court's request during the cross-examination of Ray McMillian was especially prejudicial. He asserts that the question following the conference differed from the one asked prior to the conference, and this reflects a significant decision impacting upon his constitutional rights. We disagree. While the question was rephrased, an examination of the entire line of questioning and events in the court prior to and following the conference indicates that the outcome of the conference was beneficial to the defendant. Prior to the conference, the State raised several objections regarding the relevancy of the line of questions. The court indicated just prior to the conference that it was willing to allow the line of questions to proceed to determine the relevance. After the conference, defense counsel rephrased a question but was otherwise permitted to take the line of questioning to its logical conclusion. In so doing, counsel laid the groundwork for an impeaching inference that McMillian was involved in gang activity in prison. The second conference the defendant specifically cites as being prejudicial occurred at the conclusion of the testimony of Tommy Hobbs. The defendant asserts the conference in actuality pertained to the next witness in the State's rebuttal evidence, Brenda Kirby. Since Ms. Kirby's testimony was damaging to the defendant, he asserts that he was prejudiced by not attending the conference held at his own counsel's request. While we concede that the testimony of Brenda Kirby damaged the defendant's case, after reviewing the record, we do not find any indication the conference in any way involved the testimony of Ms. Kirby. The conference was requested while the court was releasing the prior witness and before the State called Ms. Kirby to the stand. We do not find that "the subject matter of the conference implicates the defendant's confrontation rights[ ] or is of the nature that the defendant's presence would have a reasonably substantial relation to the defendant's opportunity to defend." State v. Lee, 335 N.C. at 264, 439 S.E.2d at 557. *799 The other conferences cited by the defendant were clearly held for administrative purposes and there has been no showing that the defendant's presence was necessary. We find no error in the trial court's conduct of these conferences. The defendant next contends the trial court failed to completely instruct the jury at each recess concerning the jurors' duties and responsibilities. The defendant cites twenty-eight separate instances in which the court failed to fully and adequately instruct the jury according to the requirements of N.C.G.S. § 15A-1236. N.C.G.S. § 15A-1236 provides in pertinent part: (a) The judge at appropriate times must admonish the jurors that it is their duty: (1) Not to talk among themselves about the case except in the jury room after their deliberations have begun; (2) Not to talk to anyone else, or to allow anyone else to talk with them or in their presence about the case and that they must report to the judge immediately the attempt of anyone to communicate with them about the case; (3) Not to form an opinion about the guilt or innocence of the defendant, or express any opinion about the case until they begin their deliberations; (4) To avoid reading, watching, or listening to accounts of the trial; and (5) Not to talk during the trial to parties, witnesses, or counsel. The judge may also admonish them with respect to other matters which he considers appropriate. N.C.G.S. § 15A-1236(a) (1988). The defendant acknowledges that in both State v. Harris, 315 N.C. 556, 340 S.E.2d 383 (1986), and State v. Richardson, 308 N.C. 470, 302 S.E.2d 799 (1983), this Court held that a trial court is not required to give repeatedly a full, formal rendition of the mandates found in N.C.G.S. § 15A-1236(a). However, the defendant contends the present case is distinguishable from both Harris and Richardson. In Harris, the issue revolved around the jury's exposure to a media report and the court's failure to adequately instruct on N.C.G.S. § 15A-1236(a)(4). Richardson, the defendant contends, addressed the question of whether, in the context of the entire record, the admonitions given the jury were adequate. The defendant contends the instructions cited in this case were not adequate and failed the Richardson test.
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two to three rows away from its foes and it won’t be a problem. 6. Stagger your returns. Plant a mix of vegetables that mature over different time frames. That way you’ll have a steady stream of produce over the whole season, rather than so much ripening at once that you’re scrambling to use it all before it goes bad. The little plastic sign that comes with the plant will tell you the average number of days before it matures; at the nursery, look for a mix of traditional and early-maturing plants to spread your haul throughout the season. 7. Consider companion planting. This is a technique of pairing plants together that can benefit from being near each other. For example, basil generally thrives when planted next to tomatoes or peppers, but not as well when its neighbors are beans or cucumbers; find the whole list of happy plant pairings here. Generally, root vegetables like radishes, beets, and carrots do well when planted between leafy greens, since the root veggies take up a lot of space under the soil, while lettuces don’t have very deep roots. 8. Follow spacing guidelines. The plastic signs that come with your plants will give a guideline of how much “personal space” each needs from the plants around it. Rather than thinking you’ll get more veggies if you just pack more of them into your raised bed, crowding them in can reduce air circulation, leading to pests like aphids. If the plant’s instructions say three inches, give it at least three inches, and consider it room to grow. 9. Plant flowers, too. No, you’re not going to eat them, but flowers like marigolds are more than a pretty touch. Though it’s a myth that they keep bugs away, marigolds actually do help your veggies thrive by attracting beneficial insects to your garden. 10. Close up shop. After you’ve harvested your crops and you’re putting your garden to bed for the season, get rid of dead foliage to avoid pests, then cover with a thick layer of compost. Or, plant beneficial cover crops like vetch (in the legume family) or beautiful red-topped crimson clover; when you turn it under in the spring, it will add nitrogen and other nutrients to your soil — making for an even better garden next year. Saturday, July 25, 2015 An article posted by Selco on the SHTF School on April 11, 2015. Selco always writes good stuff on website. [Source: Link to article: http://shtfschool.com/basic-survival/common-mistakes-while-bugging-out/trade post collapse] Bugging out is something that I once failed to do, because I did not even realize that it needed to be done, actually I saw what was happening but I did not „process“ the information in correct way, so I stay and had to go trough whole period of watching, doing, and getting hit by violence, together with being cold, hungry, sick and everything else. Because bugging out is so important and survival done right is often not getting into survival situations in the first place I stress importance of bugging out (if you are not already live in great bug out location anyway). Consider the following couple of mistakes that I witnessed (more than one time): Right moment Guy figured out that SHTF, something happening in the city, hears screams outside, shots, confusing news on TV, he rounds up his family, puts all bags in his car, they are armed and they go out in order to reach their bug out location in hills some 50 miles away. After one mile of traveling angry mob who just plundering local mall stops the car, pull them out, and beat them, and then kill the guy, he managed to kill few of them before that, but they were hundreds. He is dead. End of story. If you woke up in the middle of the night, because something strange happens in your town, some event, maybe terrorist attack, or martial law put into effect or whatever, sit down and think for a moment. Your mission is to leave the area and reach your bug out location, do not confuse that mission with any urge to panically run. If you go into the panic you will make mistakes, and it is definetly not time for mistakes. You would be surprised to know how many people are prone to panic, and how many of them end up dead because of that. Try to gather some information, and act accordingly to that information, who, what, when, how long, where. Try to figure out what is happening before you start to bug out to your bug out location. What are problematic areas? Who is in control? You will never have perfect information but it is better than having no information at all. Speak to neighbors, listen to the radio and TV and look on Twitter and other social media. Yes that often means you will need to postpone your trip, maybe for hours, or sometimes for even days. You need to choose the best moment to leave the area (if you already missed to leave the area before SHTF). "Right way“ SHTF and family get in their pick up, with trailer full of good equipment for SHTF time. They managed to go some 20 miles down the road, where few cars simply „get them“, block them and take everything from them. They manage to save their lives or maybe not. Who knows. Real problem here is not having right and good equipment, and lots of it. Real problem is that we are being constantly bombarded with information that we (preppers and survivalists) need to have right equipment (a lot) in order to survive. Because without it we are gonna end up dead. We are being instructed that without "things“ we are lost, we are not even right survivalists. So when SHTF we are becoming something like prisoners of our things. Guess what? I am preparing myself to bug out in my sneakers, with pistol and plastic bag. If I have to I will collect everything else what I need on my way to my bug out location. Do not get me wrong, of course I have my bug out bag, my plans, and my useful stuff for trip to my bug out location, but the point is that I am really expecting that I will find myself in situation where I need to reach bug out location without all those things. Do not accept philosophy that things will save your life. Things will help you to stay alive, but your (correct) mindset will mainly save your life. Anyway, plan to have what you need at your bug out location (already prepared), do not rely too much on things while you are bugging out, you need to be able to get things done with minimal equipment that’s why skills are more important than equipment and in best case you have both. Right mindset One word-ADAPT. If you are bug out plan plays out excatly like it should you are a very lucky man. Consider the fact, that most of you are making plans to cover hypothetical SHTF scenarios, that you seen on TV shows, read about it somewhere, member of family went through somewhere, or simply you had couple of bad experiences. It is normal. We need to guess and it is best we can do. You are building your plans based on that, nothing wrong with that. Except that everything may go wrong in one moment. You have plan to go through the city from point A to point B then to point C etc, and then to reach safe point somewhere. All good, but SHTF and your youngest son is still in school, your car is broken, and at point B in your plan something weird is happening, some kind of riot, let say with all chaos and confusion some trucks with money are rolled over right at your point B and now you need to find out a new way quickly, and your whole plan is gone, you do not know what to do. Welcome to reality! Reality usually likes to blow all your good plans to pieces. But point of planning is to COVER as many problems as you can, so make sure you play through as many scenarios as possible. For example if you have just one way out of the city it is bad plan, it needs backup and backup of the backup. UrbanMan's comment: Remember PACE Planning? Prepare for the fact that your plan will be wrong right at the beginning, and that you need to make new plan very soon, (and couple of more new plans until you reach your bug out location.) Do not end up dead because you wanted to stick to your plan because it looks good, while circumstances changed hourly around you. Survival is about quickly adapting to new situations. That is why it always helps to take a map and whatever else you need to have good sources of information to make new plans on the go. These were just few of the most important things to consider when bugging out. How do you plan to bug out. Monday, July 20, 2015 Being a huge fan of PACE planning and having redundancies for solutions to survival problems, I have a good supply of rechargeable batteries (both NiMH and NiCD types) and chargers. Some of these are the cheap versions from Lowe's or Home Depot, but my newest charger is the Maha Powerex Multi-Charger which can recharge AAA, AA, C and D sized batteries. The several versions of AAA and AA chargers I have will also be used but give me a barter capacity as I believe many people in a collapse will have not thought about batteries for their vast
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on hot-state, cold-state, and the disconnect between them: Loewenstein, G. (2005). Hot-cold empathy gaps and medical decision-making. _Health Psychology_ , _24_ , 549–556. Van Boven, L., and Loewenstein, G. (2003). Social projection of transient drive states. _Personality and Social Psychology Bulletin_ , _29_ , 1159–168. Sexual-arousal study: Ariely, D., and Loewenstein, G. (2006). The heat of the moment: The effect of arousal on sexual decision making. _Journal of Behavioral Decision Making_ , _19_ , 87–98. Direct quotes from p. 89. Arousal and sexual risk-taking in men and women: Skakoon-Sparling, S., and Cramer, K. (2014). Paretelic/telic state, sexual arousal, and sexual risk-taking in university students. _Journal of Motivation, Emotion, and Personality_ , _2_ , 32–37. Mass General PET study: Rauch, S. L., Shin, L. M., Doughtery, D. D., Alpert, N. M., Orr, S. P., Lasko, M., Macklin, M. L., Fischman, A. J., and Pitman, R. K. (1999). Neural activation during sexual and competitive arousal in healthy men. _Psychiatry Research: Neuroimaging_ , _91_ , 1–10. The "high" and "low" roads on the thalamo-cortico-amygdala connection: Ledoux, J. (1996). _The emotional brain: The mysterious underpinnings of emotional life_. New York: Simon & Schuster. On similar physiological and behavioral patterns—and neural pathways—in competitive and sexual arousal: Lang, P. J., and Bradley, M. M. (2010). Emotion and the motivational brain. _Biological Psychology_ , _84_ , 437–450. On misattribution of arousal, emotions, and not always knowing how various states affect us: Cotton, J. L. (1981). A review of research on Schachter's theory of emotion and the misattribution of arousal. _European Journal of Social Psychology_ , _11_ , 365–397. Schwarz, N. (2012). Feeling-as-information theory. In P. Van Lange, A. Kruglanski, and E. T. Higgins (eds.), _Handbook of theories of social psychology_ (pp. 289–308). Thousand Oaks, CA: Sage. Wilson, T. D., and Gilbert, D. T. (2005). Affective forecasting: Knowing what to want. _Current Directions in Psychological Science_ , _14_ , 131–134. Iowa State risk-perception study: Blanton, H., and Gerrard, M. (1997). Effect of sexual motivation on men's risk perception for sexually transmitted disease: There must be 50 ways to justify a lover. _Health Psychology_ , _16_ , 374–379. On arousal and the neuroscience of financial decisions: Platt, M. L., and Huetter, S. A. (2008). Risky business: The neuroeconomics of decision making under uncertainty. _Nature Neuroscience_ , _11_ , 398–403. Arousal and negotiation: Brown, A. D., and Curhan, J. R. (2013). The polarizing effect of arousal on negotiation. _Psychological Science_ , _24_ , 1928–1935. Arousal and consumers of advertising: Sanbonmatsu, D. M., and Kardes, F. R. (1998). The effects of physiological arousal on information processing and persuasion. _Journal of Consumer Research_ , _15_ , 379–385. Ariely quote: Ariely, D. (2009). _Predictably irrational: The hidden forces that shape our decisions_. New York: Harper, p. 128. Review of studies examining links between sports participation and more general aggressiveness: Sønderlund, A. L., O'Brien, K., Kremer, P., Rowland, B., De Groot, P. S., Zinkiewicz, L., and Miller, P. G. (2014). The association between sports participation, alcohol use and aggression and violence: A systematic review. _Journal of Science and Medicine in Sport_ , _17_ , 2–7. # WHY ATHLETES DON'T NEED AN EMPTY BED BEFORE COMPETITION Treadmill study: Boone, T., and Gilmore, S. (1995). Effects of sexual intercourse on maximal aerobic power, oxygen pulse, and double product in male sedentary subjects. _Journal of Sports Medicine and Physical Fitness_ , _35_ , 214–217. Bicycle ergometer and mental concentration test study: Sztajzel, J., Périat, M., Marti, V., Krall, P., and Rutishauser, W. (2000). Effect of sexual activity on cycle ergometer stress test parameters, on plasmatic testosterone levels and on concentration capacity. _Journal of Sports Medicine and Physical Fitness_ , _40_ , 233–239. Direct quote from p. 239. Rutgers study of female orgasms and pain threshold: Whipple, B., and Komisaruk, B. R. (1985). Elevation of pain threshold by vaginal stimulation in women. _Pain_ , _21_ , 357–367. Jannini study: Jannini, E. A., Screponi, E., Carosa, E., Pepe, M., Lo Diudice, F., Trimarchi, F., and Benvenga, S. (2001). Lack of sexual activity from erectile dysfunction is associated with a reversible reduction in serum testosterone. _International Journal of Andrology_ , _22_ , 385–392. McGlone, S., and Schrier, I. (2000). Does sex the night before competition decrease performance? _Clinical Journal of Sport Medicine_ , _10_ , 233–234. Survey of athletes' beliefs: Pupiš, M., Rakovic´, A., Stankovic´, D., Kocic´, M., and Savanovic´, V. (2010). Sex and endurance performance. _International Journal of Kinesiology_ , 7 _,_ 21–25. # WHY THE COACH'S SEAT IS _ALWAYS_ HOT NFL coaching-change study: Roach, M. A. (2013). Mean reversion or a breath of fresh air? The effect of NFL coaching changes on team performance in the salary cap era. _Applied Economics Letters_ , _20_ , 1553–1556. Direct quotation: p. 1556. College football coaching changes: Adler, E. S., Berry, M. J., and Doherty, D. (2013). Pushing 'reset': The conditional effects of coaching replacements on college football performance. _Social Science Quarterly_ , _94_ , 1–28. Direct quotations: p. 1. Hockey coaching changes: http://fivethirtyeight.com/​features/​what-predicts-if-an-nhl-coach-will-be-fired-and-whether-it-matters/. Baseball coaching changes: Allen, M. P., Panian, S. K., and Lotz, R. E. (1979). Managerial succession and organizational performance: A recalcitrant problem revisited. _Administrative Science Quarterly_ , _24_ , 167–180. English soccer study: Audas, R., Dobson, S., and Goddard, J. (2002). The impact of managerial change on team performance in professional sports. _Journal of Economics and Business_ , _54_ , 644–650. Serie A study: De Paola, M., and Scoppa, V. (2012). The effects of managerial turnover: Evidence from coach dismissals in Italian soccer teams. _Journal of Sports Economics_ , _13_ , 152–168. NBA coaching changes: Pfeffer, J., and Davis-Blake, A. (1986). Administrative succession and organizational performance: How administrator experience mediates the succession effect. _Academy of Management Journal_ , _29_ , 72–83. College basketball: Eitzen, D. S., and Yetman, N. R. (1972). Managerial change, longevity, and organizational effectiveness. _Administrative Science Quarterly_ , _17_ , 110–116. CEO firings: Wiersema, M. (2002). Holes at the top: Why CEO firings backfire. _Harvard Business Review_ , _80_ , 70–77. Direct quotations: pp. 2, 4. Investing study: Barber, B. M., and Odean, T. (2000): Trading is hazardous to your wealth: The common stock investment performance of individual investors. _Journal of Finance_ , _55,_ 773–806 _._ Soccer penalty-kick study: Bar-Eli, M., Azar, O. H., Ritov, I., Keidar-Levin, Y., and Schein, G. (2007). Action bias among elite soccer goalkeepers
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o file -d file.gpg # Decrypt. Use -o or it goes to stdout Encrypt - Decrypt with keys First you need to export your public key for someone else to use it. And you need to import the public say from Alice to encrypt a file for her. You can either handle the keys in simple ascii files or use a public key server. For example Alice export her public key and you import it, you can then encrypt a file for her. That is only Alice will be able to decrypt it. # gpg -a -o alicekey.asc --export 'Alice' # Alice exported her key in ascii file. # gpg --send-keys --keyserver subkeys.pgp.net KEYID # Alice put her key on a server. # gpg --import alicekey.asc # You import her key into your pubring. # gpg --search-keys --keyserver subkeys.pgp.net 'Alice' # or get her key from a server. Once the keys are imported it is very easy to encrypt or decrypt a file: # gpg -e -r 'Alice' file # Encrypt the file for Alice. # gpg -d file.gpg -o file # Decrypt a file encrypted by Alice for you. Key administration # gpg --list-keys # list public keys and see the KEYIDS The KEYID follows the '/' e.g. for: pub 1024D/D12B77CE the KEYID is D12B77CE # gpg --gen-revoke 'Your Name' # generate revocation certificate # gpg --list-secret-keys # list private keys # gpg --delete-keys NAME # delete a public key from local key ring # gpg --delete-secret-key NAME # delete a secret key from local key ring # gpg --fingerprint KEYID # Show the fingerprint of the key # gpg --edit-key KEYID # Edit key (e.g sign or add/del email) Encrypt and decrypt:Note that the file can of course be a tar archive. GnuPG is well known to encrypt and sign emails or any data. Furthermore gpg and also provides an advanced key management system. This section only covers files encryption, not email usage, signing or the Web-Of-Trust.The simplest encryption is with a symmetric cipher. In this case the file is encrypted with a password and anyone who knows the password can decrypt it, thus the keys are not needed. Gpg adds an eDisclaimer: Please note that the writer is not responsible for dead, boring, mind expanding or dangerous website links and/or software, follow links and install programs at your own risk! Friday, September 03, 2004 "Turing the Countryside, O Frabjous Day!" While it seems simple to press the keys on our keyboards and see words appear on our monitors and then e-mail them halfway around the world, the base science of such matters are what an old guru I once knew described as an "FM Unit". "My Boy", he would begin, "Folks today just don't understand how computers work, they all expect to open the cover and find an FM Unit controlling everything". I would inquire just what an FM Unit was. "Friggin Magic", he would respond, "they all think technology runs on crystal balls and pixie dust." To the same end, Arthur C. Clarke, author of "2001: A Space Odyssey", stated: "Any sufficiently advanced technology is indistinguishable from magic". But has modern technology really advanced to the point where it is indistinguishable from magic? There are thousands of computer scientists in the world who would chortle a resounding "NAY!" Alan Turing ( http://www.turing.org.uk/turing/index.html ), founder of modern computer science would most likely be responsible for the loudest chortles, but at the same time awe-struck at the evolution of his conceptual "Turing Machines" to today's personal computers to tomorrow's thinking machines. Always a visionary ahead of his time, in 1950, and without benefit of today's motion pictures such as "The Matrix", "Terminator" and "2001"", Alan Turing asked, "Can a Machine Think?". To his logic, the only answer was yes, but this belayed an even larger question to his philosophical mind, "If a computer could think, how could we tell?" Turing went on to develop "The Turing Test", a practical methodology for testing a computer's ability to think by attempting to deceive an interrogator into believing they are chatting with a real person. Today, "Completely Automated Public Turing test to tell Computers and Humans Apart" or CAPTCHAs ( http://www.parc.xerox.com/research/istl/projects/captcha/ ) have recently become commonplace on the Internet, taking the form of code boxes that are currently only decipherable by human minds. Magic or Science? That's for you to decide, just be aware that "I'm sorry Dave, I'm afraid I can't do that" may take on a whole new meaning when the Turing Police show up with a warrant to arrest your home computer!New Delhi: The elite Sindh Club in port city Karachi refused to host Indian High Commissioner to Pakistan TCA Raghavan on September 26, a report said on Thursday. According to a report published in 'The Times of India', Raghavan and his wife had got an invite and when they reached the hotel for the event, they were informed that Sindh Club has decided not to host them. The event was organised by Pakistan-India Citizens' Friendship Forum. Pakistan's founder Muhammad Ali Jinnah's grandson Liaquat Merchant is the co-chairman of the group. The Club never gave the reason as to why it cancelled the invitation at the last moment. Earlier this month, Pakistani singer Ghulam Ali's concert, scheduled to take place at Shanmughananda Hall in Mumbai, was cancelled after the Shiv Sena threatened to disrupt the show. In the last few weeks, Sena has hit national headlines with its protest against Pakistani ghazal singer Ghulam Ali's concerts in Pune and Mumbai (which were consequently cancelled), ink attack on former BJP ideologue Sudheendra Kulkarni and opposition to release of former Pakistan foreign minister Khurshid Kasuri's book, as well as protest at BCCI office over the planned visit by Pakistan Cricket Board chief.Q: Why is edit question feature unavailable? I wanted to edit this question for giving some sanity to it, but saw that the Edit feature is seen disabled. Why is it so? N.B: I can edit other questions. Image: Edit feature is shown disabled (highlighted in red): A: If you did read the tooltip over the disabled edit button, it would have told you there is a pending suggested edit waiting to be reviewed. Anyway, I have reviewed the suggested edit and you should now be able to edit the question if you want to. See also: Why is the edit button disabled? SoCal Sanctions: Why The Captains Of Four Teams Couldn’t Play Saturday Of Regionals Altered scores after heat-shortened games lead to punishment. To the outside observer, the Southwest Mixed Regional Club Championships occurred without incident; the three bid-earning squads advanced to Nationals with convincing performances in their elimination games. On paper, the biggest story coming out of the weekend was Mischief sputtering on Saturday and slaying on Sunday en route to a tournament title. And while the tournament itself went very smoothly for an event with only three volunteers on hand during the weekend, there was an asterisk on the action. On Tuesday, September 18th, five days before Regionals was set to start, USA Ultimate sent an email to the captains of Santa Barbara Robots, Phoenix ROBOS, L.A. Family Style, and L.A. 7 Figures informing them that they would be unable to compete with their teams on Saturday. The captains would not even be allowed to set foot on the fields until Sunday morning. Sectionals Scores & Sanctions While the email may have come as a surprise to the SoCal captains, the cause for the sanctions was clear. On Sunday during Sectionals, all four teams had one final game. 7 Figures was set to play Robot; Family Style was set to play ROBOS. All four teams had already qualified for Regionals by this point: the final game was strictly to determine seeding. The temperature in Tucson, Arizona where the tournament was being held had already exceeded 100 degrees, and the heat index was threatening to match that during the round. Per USAU rules, if the heat index rose above 100, play would have to be suspended. The captains of the four teams were informed that they were allowed to continue under the current conditions or wait until 6 PM for the heat to dissipate.1 Because of the implications for Regionals seeding, the teams were alerted of the high temperature but told by staff members that they had to play their games, or at the very least wait until 6 PM before they could make any decisions about forfeiture. That put a strain on many of the teams set to play. Some had players whose flights were scheduled to depart before 6 PM while others were just worried about what time they would arrive home. The drive from Tucson to Los Angeles
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light_tempo == 0 && ((lcd_flags & LCD_FLAG_L) == 0)) lcd_backlight(1); light_tempo = FLASH_LIGHT_TEMPO; } processed = 1; break; case 'f': /* Small Font */ lcd_flags &= ~LCD_FLAG_F; processed = 1; break; case 'F': /* Large Font */ lcd_flags |= LCD_FLAG_F; processed = 1; break; case 'n': /* One Line */ lcd_flags &= ~LCD_FLAG_N; processed = 1; break; case 'N': /* Two Lines */ lcd_flags |= LCD_FLAG_N; break; case 'l': /* Shift Cursor Left */ if (lcd_addr_x > 0) { /* back one char if not at end of line */ if (lcd_addr_x < lcd_bwidth) lcd_write_cmd(0x10); lcd_addr_x--; } processed = 1; break; case 'r': /* shift cursor right */ if (lcd_addr_x < lcd_width) { /* allow the cursor to pass the end of the line */ if (lcd_addr_x < (lcd_bwidth - 1)) lcd_write_cmd(0x14); lcd_addr_x++; } processed = 1; break; case 'L': /* shift display left */ lcd_left_shift++; lcd_write_cmd(0x18); processed = 1; break; case 'R': /* shift display right */ lcd_left_shift--; lcd_write_cmd(0x1C); processed = 1; break; case 'k': { /* kill end of line */ int x; for (x = lcd_addr_x; x < lcd_bwidth; x++) lcd_write_data(' '); /* restore cursor position */ lcd_gotoxy(); processed = 1; break; } case 'I': /* reinitialize display */ lcd_init_display(); lcd_left_shift = 0; processed = 1; break; case 'G': { /* Generator : LGcxxxxx...xx; must have <c> between '0' * and '7', representing the numerical ASCII code of the * redefined character, and <xx...xx> a sequence of 16 * hex digits representing 8 bytes for each character. * Most LCDs will only use 5 lower bits of the 7 first * bytes. */ unsigned char cgbytes[8]; unsigned char cgaddr; int cgoffset; int shift; char value; int addr; if (strchr(esc, ';') == NULL) break; esc++; cgaddr = *(esc++) - '0'; if (cgaddr > 7) { processed = 1; break; } cgoffset = 0; shift = 0; value = 0; while (*esc && cgoffset < 8) { shift ^= 4; if (*esc >= '0' && *esc <= '9') value |= (*esc - '0') << shift; else if (*esc >= 'A' && *esc <= 'Z') value |= (*esc - 'A' + 10) << shift; else if (*esc >= 'a' && *esc <= 'z') value |= (*esc - 'a' + 10) << shift; else { esc++; continue; } if (shift == 0) { cgbytes[cgoffset++] = value; value = 0; } esc++; } lcd_write_cmd(0x40 | (cgaddr * 8)); for (addr = 0; addr < cgoffset; addr++) lcd_write_data(cgbytes[addr]); /* ensures that we stop writing to CGRAM */ lcd_gotoxy(); processed = 1; break; } case 'x': /* gotoxy : LxXXX[yYYY]; */ case 'y': /* gotoxy : LyYYY[xXXX]; */ if (strchr(esc, ';') == NULL) break; while (*esc) { if (*esc == 'x') { esc++; if (kstrtoul(esc, 10, &lcd_addr_x) < 0) break; } else if (*esc == 'y') { esc++; if (kstrtoul(esc, 10, &lcd_addr_y) < 0) break; } else break; } lcd_gotoxy(); processed = 1; break; } /* Check wether one flag was changed */ if (oldflags != lcd_flags) { /* check whether one of B,C,D flags were changed */ if ((oldflags ^ lcd_flags) & (LCD_FLAG_B | LCD_FLAG_C | LCD_FLAG_D)) /* set display mode */ lcd_write_cmd(0x08 | ((lcd_flags & LCD_FLAG_D) ? 4 : 0) | ((lcd_flags & LCD_FLAG_C) ? 2 : 0) | ((lcd_flags & LCD_FLAG_B) ? 1 : 0)); /* check whether one of F,N flags was changed */ else if ((oldflags ^ lcd_flags) & (LCD_FLAG_F | LCD_FLAG_N)) lcd_write_cmd(0x30 | ((lcd_flags & LCD_FLAG_F) ? 4 : 0) | ((lcd_flags & LCD_FLAG_N) ? 8 : 0)); /* check wether L flag was changed */ else if ((oldflags ^ lcd_flags) & (LCD_FLAG_L)) { if (lcd_flags & (LCD_FLAG_L)) lcd_backlight(1); else if (light_tempo == 0) /* switch off the light only when the tempo lighting is gone */ lcd_backlight(0); } } return processed; } static ssize_t lcd_write(struct file *file, const char *buf, size_t count, loff_t *ppos) { const char *tmp = buf; char c; for (; count-- > 0; (ppos ? (*ppos)++ : 0), ++tmp) { if (!in_interrupt() && (((count + 1) & 0x1f) == 0)) /* let's be a little nice with other processes that need some CPU */ schedule(); if (ppos == NULL && file == NULL) /* let's not use get_user() from the kernel ! */ c = *tmp; else if (get_user(c, tmp)) return -EFAULT; /* first, we'll test if we're in escape mode */ if ((c != '\n') && lcd_escape_len >= 0) { /* yes, let's add this char to the buffer */ lcd_escape[lcd_escape_len++] = c; lcd_escape[lcd_escape_len] = 0; } else { /* aborts any previous escape sequence */ lcd_escape_len = -1; switch (c) { case LCD_ESCAPE_CHAR: /* start of an escape sequence */ lcd_escape_len = 0; lcd_escape[lcd_escape_len] = 0; break; case '\b': /* go back one char and clear it */ if (lcd_addr_x > 0) { /* check if we're not at the end of the line */ if (lcd_addr_x < lcd_bwidth) /* back one char */ lcd_write_cmd(0x10); lcd_addr_x--;
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يل سوف تتيح لنا استئناف التنفيذ عند هذه النقطة المحددة. >> لاحظ أن هناك زوجين من الآخر الأزرار المتاحة في هذا الفريق التصحيح كذلك. خطوة أكثر، مما يتيح لي الفرصة ل تنفيذ هذا سطر واحد من التعليمات البرمجية وخطوة الى أن خط إلى المرحلة التالية. وهو في هذه الحالة يعني أن يتم تنفيذ بيان printf وسوف نتوقف ثم التنفيذ على خط 13 مثل ذلك. وهناك أيضا الخطوة إلى وظيفة التي مفيد إذا كنت قد خلقت الآخرين وظائف في أماكن أخرى في التعليمات البرمجية المصدر وأريد أن خطوة الى هذه الوظائف بدلا من تنفيذ هذه المهمة ككل. ولكننا سوف تبدو أكثر على هذه الخطوة إلى وظيفة في مجرد لحظة. الآن، لاحظ بعض الأشياء الأخرى التي موجودة فعلا داخل هذا الفريق التصحيح. لدينا هذا الفريق يسمى الاستدعاءات الذي يبين لنا أين بالضبط ما نحن عليه. في هذه الحالة، نحن داخل الرئيسي وظيفة، ويسمى النصي لدينا count.c، ونحن يحدث ليكون على خط 13 عمود واحد. Dutch: en het raken van de Play knop ons toelaten om de uitvoering te hervatten op dat specifieke moment. >> Merk op dat er een paar andere knoppen beschikbaar in Debug panel ook. Stap dan, die mij toelaat om voeren dat een regel code en stap over naar die lijn naar de volgende. Wat in dit geval betekent dat het printf statement wordt uitgevoerd en het zal dan pauzeren executie op lijn 13 zoals zo. En er is ook een stap In functie die is handig als ik andere hebben gecreëerd functies elders in de broncode en ik wil om de stap naar die functies plaats voeren die functie als geheel. Maar we zullen meer kijken naar deze stap In functie in slechts een moment. Nu, een aantal andere dingen die werkelijk bestaan ​​binnen deze Debug panel. Wij hebben dit panel noemde de Call Stack die laat ons zien waar we precies zijn. In dit geval we binnen de belangrijkste functie, is ons script count.c genoemd, en we toevallig op lijn 13 een kolom. Catalan: i colpejar el botó Play ens permet reprendre l'execució en aquest punt específic. >> Observi que hi ha un parell d'altres botons disponibles en aquest panell de depuració tant be. Pas a pas per, el que em permet executar que una línia de codi i passar per sobre a aquest línia a la següent. Que en aquest cas significaria que s'executa la sentència printf i serà llavors una pausa l'execució de la línia 13 com a tal. I també hi ha un pas En funció de la qual és útil si he creat una altra funcions en altres llocs en el codi font i vull entrar en aquestes funcions en lloc de executar aquesta funció com un tot. Però anem a veure més en aquest Pas En funció en un moment. Ara, observeu algunes altres coses que realment existir dins d'aquest panell de depuració. Tenim aquest panell anomenat Pila de trucades que ens mostra exactament on som. En aquest cas, estem dins dels principals funció, el nostre script es diu count.c, i que estiguem en la línia 13 la columna un. Bengali: এবং প্লে বাটন হবে আঘাত আমাদের মৃত্যুদন্ড পুনরায় শুরু করার অনুমতি যে নির্দিষ্ট সময়ে. >> অন্যান্য দুয়েক আছে বিজ্ঞপ্তি এই ডিবাগ প্যানেল পাওয়া বোতাম আরো. আমাকে যা করতে পারবেন, আসিতে কোড যে এক লাইন চালানো এবং যে উপর পইঠা পরের এক লাইন. যে অর্থ হবে এই ক্ষেত্রে যা printf বিবৃতিতে মৃত্যুদন্ড কার্যকর করা হয় এবং তারপর বিরতি হবে তাই ভালো লাইন 13 মৃত্যুদন্ড. এবং একটি ধাপ আছে ফাংশন মধ্যে যা আমি অন্য তৈরি করেছেন তাহলে দরকারী সোর্স কোড অন্যত্র ফাংশন এবং আমি ভাগ দিতে চান যারা ফাংশন বদলে সামগ্রিকভাবে যে ফাংশন চালানো. কিন্তু আমরা এই পদক্ষেপ এ আরো দেখুন করব মাত্র কয়েক মিনিটের মধ্য
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B10]\]. An increased activation of central respiratory centers results not only into an increase in minute ventilation but also into an increased perception of dyspnea \[[@B20]\]. The basis for this awareness originates from the exchange in information between the motor and sensory cortex and is referred to as corollary discharge \[[@B20]\]. Although the work of breathing is not the sole cause of dyspnea, increased effort as a result from an increased mechanical load causes a heightened sense of respiratory effort. Consequently, this may explain the strong correlation between the dyspnea score and the respiratory drive in the present study. This drive can be easily measured using mouth occlusion pressures at rest. As our results indicate, it better relates to dyspnea than impairment in lung volumes or gas transfer and may be present before significant impairment in these function tests arises. Therefore, measurement of the neuromuscular inspiratory drive may function in clinical practice in SSc patients complaining of dyspnea as a screening tool for detection of ILD or PAH. Ventilation and its components, tidal volume and breathing frequency, depend on the compliance of the respiratory system and airway resistance \[[@B3],[@B9]-[@B11]\]. Importantly, one would like to differentiate patients who will not breathe because of central or neuromuscular inadequacy from those who cannot breathe because of mechanical abnormalities of the chest. The ventilatory response to hypercapnia is known for its large variability and reported responses may vary from 2.0 to 4.7 L/min/mmHg \[[@B3],[@B17]\]. Although a correction by FVC will lead to less variability (reported values vary from 0.42 to 0.94 FVC/min/mmHg \[[@B3]\]), measuring the respiratory drive in patients affected by ILD using ventilatory parameters remains troublesome. The mouth occlusion pressure generated by the inspiratory muscles at functional residual capacity (P0.1) has been proposed as an useful test to avoid these disadvantages \[[@B3],[@B9]-[@B11]\]. It is independent of flow resistance and respiratory compliance and less variability is observed in various subjects \[[@B3],[@B10]\]. Taken this together, we argue that ventilation and its components, may not represent an accurate output of the respiratory drive in our patients. In daily practice, measuring P0.1 is very simple to apply and joined with a rebreathing bag, measurement of CO~2~ responsiveness is possible. In normal subjects, P0.1 values of 0.75-1.5 cmH~2~0 have been described \[[@B3],[@B10]\]. In addition, normal V'E/P0.1 is defined by ≥ 8 L/min/cmH~2~O, as evaluated by Scott and Burki \[[@B10]\]. The responsiveness to hypercapnia by measuring P0.1 (∆P0.1/∆PetCO~2~) in normal subjects is reported to be 0.17-0.49 cmH~2~O/mmHg \[[@B3],[@B16]\]. This is in agreement with our results of SSc patients with a normal V'E/P0.1 (Table [2](#T2){ref-type="table"}, mean ∆P0.1/∆PetCO~2~ 0.45 cmH~2~O/mmHg). Thus, in these SSc patients, the respiratory compliance and airflow resistance did not affect occlusion pressures or the responsiveness to hypercapnia and is therefore considered to be normal. Furthermore, our data of mouth occlusion pressures during resting minute ventilation and during CO~2~ rebreathing in patients with normal V'E/P0.1 are consistent with those of others \[[@B3],[@B7],[@B10],[@B21]\]. However, in the present study no significant difference was seen in ∆V'E/∆PetCO~2~ between the groups as classified by V'E/P0.1 (Table [2](#T2){ref-type="table"}). Since there was a significant difference present between these groups using mouth occlusion pressures, minute ventilation may not represent the neuromuscular drive adequately in SSc patients with an increased respiratory impedance. Although our reported values of the respiratory drive, as measured by P0.1, were approximately similar, differences from those previously reported by Walterspacher et al. are present \[[@B21]\]. Potential reasons may include the differences in degree of restrictive lung function as measured by FVC% predicted. Our SSc patients with an abnormal V'E/P0.1 had mildly reduced FVC% predicted and may have preserved inspiratory muscle function. Furthermore, our SSc patients did not avoid activities provoking dyspnea resulting into deconditioning and muscle wasting. Secondly, they did not use immunosuppressive agents affecting respiratory muscle function (prednisone). Finally, polyneuropathy, which may cause an impaired respiratory muscle function, was not likely in our patients. Therefore, respiratory drive was considered to be appropriate in our SSc population. In our study, patients with a low V'E/P0.1 had an increased responsiveness to hypercapnia which suggests an increased central respiratory drive (Table [2](#T2){ref-type="table"}). This group was characterized by fewer limited SSc patients, a lower forced vital capacity, more impaired gas transfer and a lower lung volume (Table [1](#T1){ref-type="table"}). Importantly, the majority of these patients had evidence of interstitial lung disease on their HRCT and some patients had an elevated tricuspid insufficiency gradient (data not shown). The disease duration did not differ between these groups. The difference in V'E/P0.1 between the groups are related to SSc disease severity and therefore influence the impedance of the respiratory system. Consequently, differences in V'E/P0.1 were observed. Similar results are reported by Gorini and coworkers in normocapnic ILD patients without SSc \[[@B7]\]. This contrasts to the concept of gradual down-regulation in central respiratory sensitivity for carbon dioxide in scleroderma patients \[[@B4]\]. DiMarco and coworkers concluded that in patients with ILD, non-chemical, and presumably neural, mechanisms, both increase respiratory drive and alter the breathing pattern \[[@B22]\]. Several factors may influence the central sensitivity to CO~2~ as measured by the ventilatory response to hypercapnia, such as the hormonal status, sex, age, use of sedative agents and caffeine \[[@B8],[@B17]\]. However, these factors will generally not result into an abnormal V'E/P0.1 since the compliance of the respiratory system or airway resistance is not affected. Some considerations may apply to our study. First, we evaluated MOP and CO~2~ rebreathing in patients with systemic sclerosis. We used a dataset of normal values for normal resting minute ventilation as a function of occlusion pressures (V'E/P0.1) \[[@B10]\]. As reported by others a value higher than 8 L/min/cmH~2~O, independent of age or sex, identifies subjects with normal PFTs and therefore provides a reliable index of respiratory drive \[[@B3],[@B10]\]. Consequently, we restricted our measurements in a patient group, only classified by V'E/P0.1. Our study contained 73 patients, which was similar to previous studies evaluating mouth occlusion pressures \[[@B3],[@B10]\], and considered to be sufficient for group difference statistics. Despite the relatively mild range in low dyspnea scores (range 0--21; Figure [1](#F1){ref-type="fig"}), a significant difference in V'E/P0.1 and ∆P0.1/∆PetCO~2~ was present (Table [2](#T2){ref-type="table"}), indicating the sensitivity of the mouth occlusion pressure test. Furthermore, assessing V'E/P0.1 to an additional load such as exercise may have increased this difference since airflow resistance will increase and consequently the impedance of the respiratory system. Secondly, we did not measure the sensation of dyspnea, as assessed at rest by the UCSD questionnaire, during CO~2~ rebreathing. To evaluate the relationship between the intensity of dyspnea and respiratory chemosensitivity may have strengthen our results, however this questionnaire was not designed to be administered during a rebreathing or exercise test. Conclusions =========== In summary, the results of the present study show that patients with systemic sclerosis display a substantial variability in the ventilatory response to hypercapnia. In contrast, mouth occlusion pressures, independent of respiratory compliance or airflow resistance, provide an accurate outcome parameter in combination with minute ventilation as an initial evaluation for mild dyspnea. They better relate to the magnitude of patient reported dyspnea than traditional lung function parameters such as FVC or DLCO% predicted. Furthermore, in our SSc patients with an abnormal V'E/P0.1, an increased respiratory drive to hypercapnia was present. Since dyspnea is one of the most frequently reported symptoms at first consultation in SSc, an easy test to discriminate between normal or abnormal respiratory mechanics would be obligatory. Therefore, we suggest that an abnormal V'E/P0.1 in combination with reported dyspnea indicates further assessment of respiratory involvement in SSc patients. Competing interests =================== The authors declare they have no competing interests. Authors' contributions ====================== MKN, WBGJH, AJMS and JS designed the study. MKN, WBGJH, AJMS, JS all contributed to the clinical work for the study. MKN, WBGJH and JS analyzed the data and wrote the manuscript. All authors read and approved the final manuscript. Pre-publication history ======================= The pre-publication history
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/k**(-10)*k)) assuming k is positive. k**(25/19) Simplify s/(s*s**(1/5)/s)*s**(-9)*s*(s**1)**(18/11) assuming s is positive. s**(-306/55) Simplify (q**(-4/9))**32*q*q*(q**(2/29)*q*q)/q*q**(-16) assuming q is positive. q**(-7087/261) Simplify m/(m**22/m)*m**(9/5)*m**(-1/5)/m*m*m*m**(-3/5) assuming m is positive. m**(-18) Simplify (h/(h/(h*h**1))*h)**16/(h*h/(h*h/h**(2/3)))**42 assuming h is positive. h**20 Simplify (k**(2/3)*k/((k/(k/(k/(k/(k/k**10*k)))))/k))/(k**(2/17)/(k*k/(k/(k*k*k**(-2)/k*k))*k)) assuming k is positive. k**(640/51) Simplify (d/(d/d**(3/4)))**(-48)*(d**(6/5)*d*d)**(-18) assuming d is positive. d**(-468/5) Simplify (b/(b/(b**9*b)))/b*b*b**3*(b**6)**(-38) assuming b is positive. b**(-215) Simplify ((f*f*f*f/(f*f**(-12)))/(f**(-1/26)/f))/(f*f*f**9*f*f*f)**(-34) assuming f is positive. f**(12793/26) Simplify ((n/(n*n*(n/(n**(2/9)*n)*n)/n*n))/(n*n*n**(10/3)))/(n**(2/19)/n)**(3/16) assuming n is positive. n**(-18997/2736) Simplify ((n**(-2/5))**28*n**2*n*n*(n*(n**(2/15)/n)/n)/n)**(1/17) assuming n is positive. n**(-8/15) Simplify ((d*d**(-3)*d*d*(d/(d*d/d**(4/3)))/d)/(d/((d*d*d/d**(1/4))/d))**(-27))**40 assuming d is positive. d**(-2510/3) Simplify (q*q/q**(-11)*q*q*((q/(q/(((q/(q**(-12)*q))/q*q)/q)))/q)/q*q)/(q*q**(1/6)*q*q*q)**(14/11) assuming q is positive. q**(650/33) Simplify ((u/(u*u*u**2)*u/u**0)/(u**(-1/2))**(-6))**(2/39) assuming u is positive. u**(-10/39) Simplify ((l**(-2/9)/l)/l)/l**(-2/29)*(l*l*l**(2/85)*l)/l**(-22) assuming l is positive. l**(507377/22185) Simplify v**7/(v*v**(-25))*(v*v**(-2/3)*v*v)/v**20 assuming v is positive. v**(40/3) Simplify (m*m*m**8)**(-1/9)*(m*m**9)/m**(-14) assuming m is positive. m**(206/9) Simplify (o/((o**(-2)*o)/o)*o/o**(-2/25))/(o**(2/27))**20 assuming o is positive. o**(1754/675) Simplify ((y*y**(-14))/(y*y*(y**(-22)*y*y*y)/y*y))/(y**3*y**(-14/5)) assuming y is positive. y**(19/5) Simplify ((a*a/(a/a**(2/9)))**47)**(8/11) assuming a is positive. a**(376/9) Simplify m**1/m**(-3/2)*m**(-6)*m/m**(1/11) assuming m is positive. m**(-57/22) Simplify ((u*u**2)**4*(u**1)**(2/23))**(1/47) assuming u is positive. u**(278/1081) Simplify (o**(1/3)*o)**(-26)/(o**(-2/5)*o*o**(2/11)*o) assuming o is positive. o**(-6014/165) Simplify ((w/((w*w**(4/9)/w*w)/w))/w)**(2/27)*w**(-5/3)*w*w*w/(w*w/(w/(w**5/w)))*w assuming w is positive. w**(-656/243) Simplify ((d**(-2/7)/d)**2)**(2/73) assuming d is positive. d**(-36/511) Simplify (d*(d/(d/(d/((d*d*d**(4/7))/d)))*d*d)/d*d)/d**(6/17)*(d**8)**(3/29) assuming d is positive. d**(10019/3451) Simplify ((q*q**(1/4))**(-2/21)/(q/(q*q/q**(-2/7)*q)*((q/(q/q**7)*q)/q)/q*q))**(18/11) assuming q is positive. q**(-87/11) Simplify ((n/(((n/n**(-3))/n)/n))/(n**(1/9)/n))/(n*n**(-2/9)*n)**8 assuming n is positive. n**(-43/3) Simplify (z**24/z*((z**(-23)*z)/z)/z)/((z**(-15)*z)/(z*z**(2/23)*z*z*z)) assuming z is positive. z**(393/23) Simplify ((v**8*(v/(v*v**(3/4)*v*v))/v)**4)**(-15) assuming v is positive. v**(-255) Simplify ((v**4/v)**(-2/129))**(17/6) assuming v is positive. v**(-17/129) Simplify ((k/(k**(-1)*k))**(-2/17)*(k*k*(k**5*k*k)/k)/((k**0*k*k*k)/k))**9 assuming k is positive. k**(900/17) Simplify ((a/a**7)/(a/(a**(-1/5)/a)))/(a*a**(2/5)*a/a**(-1/16)) assuming a is positive. a**(-853/80) Simplify (j/(j/(j*j**(-29)/j*j*j*j))*j**(2/5))/(j**(-13))**37 assuming j is positive. j**(2277/5) Simplify (y/((y*y**(-1/7))/y))/(y**(1/4)*y)*(y*y**(-1))/(y*y/y**(-4/17)) assuming y is positive. y**(-1115/476) Simplify ((h**7)**2)**(-2/141) assuming h is positive. h**(-28/141) Simplify (x*(x/(x*x**(-4/15)))/x*x)**(-50)*(x*x/(x/((x*x*x**(-28))/x)))/((x**(11/5)/x)/x) assuming x is positive. x**(-1343/15) Simplify (x**(1/4)*x)**(-14/9)/(x**(2/29)/x*((x/((x*x**(2/19)*x)/x*x))/x)/x) assuming x is positive. x**(20747/9918) Simplify ((a**(1/2))**(4/7)*(a/(a*a*a/a**(-2/13))*a)/(a/(((a**(-2)*a)/a)/a)))**(2/85) assuming a is positive. a**(-886/7735) Simplify (j**(1/8))**(7/8)/(j**9/(j/(j*j**(5/2))*j)) assuming j is positive. j**(-665/64) Simplify ((c**0*c*c)**(-1/14)/((c**(-1/4)*c)/c*c*(((c/((c*(c/c**(-5/2))/c)/c))/c*c*c)/c)/c))**(-1/29) assuming c is positive. c**(-45/812) Simplify q/q**17*q/(q*q**(8/5))*((q**(8/5)*q*q)/q*q)/(q/(q*q*q*q/(q*q**15*q))) assuming q is positive. q**(-28) Simplify p**(-2/3)*p*p**37*p*(p**(-9/10)/p)/(p*p*p**(-2/13)*p) assuming p is positive. p**(13099/390) Simplify (k**(-1)*k*(
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conservation. This year was an incredible year for technology. As the holidays rapidly approach, Avnet’s employees from around the world weighed in on their holiday tech wishes this year. With responses that range from retro to futuristic, there’s no denying our teams’ tech enthusiasm. Take note all you last-minute shoppers! Rick Hamada, CEO“Any app or gadget that could improve my golf game might be of interest.” Darren Adams, vice president and general manager, Avnet Technology Solutions, Australia/NZ “I like those digital picture frames. If someone could find a battery/portable one of those that I could take on tour with me when I travel that would be fantastic! I just bought a Sonos sound system and think that’s a very cool way to have the whole family listen to music of their choice.” Jennifer Daake, vice president, Global HR Operations “I actually received my holiday technology gift early – an upgrade of my phone from iPhone 4s to a 6! I wanted a larger screen because so many activities, both personal and professional, are now mobile.” Mike McCoy, vice president, assistant general council “As I have been good this year, I am hoping to get the GoPro Hero 4 with the Dive Bundle. I recently received my SCUBA license and I hope to go diving this spring. I would love to be able to record my dive and show my kids what I was able to do. Since I am not paying for it, I also would not complain if I received the Samsung 75-inch 4K TV so that I can watch my zombie shows and University of Arizona basketball in UltraHD. I behaved better this year so I am hoping Santa comes through!” Sean Valcamp, director enterprise architecture and security services, Avnet Global Information Solutions “This year I am hoping Santa brings the Internet of Things to my stocking. By this I mean sensors and specifically the 3Bays GSA PRO golf swing analyzer. This provides immediate feedback about my golf swing to my smartphone. Now if there was only a sensor that could fix my swing!” Alan Chui, regional president, Avnet Electronics Marketing, Asia“This year Google Glass has taken the top spot on my Holiday Tech Wish List. Although the new gadget is being peppered with many questions from technology experts and its huge base of Google fans, I am drawn by how intuitive the cool gadget is. I like the camera feature where I could take hands-free photos by using my voice to instruct Google Glass to capture images and then upload them on social media sites. As I travel a lot, the intuitive software also allows me to receive up-to-date information on flights, weather, traffic conditions, etc. And all this information just appears in the right corner of my vision!” Rusty Murdaugh, vice president, financial planning and analysis “I am hoping to receive a drone this year (or maybe next year). I think this technology is pretty cool and I would like to try this method of flying versus getting up in the air myself behind the controls.“ Steve Phillips, chief information officer “This is a relatively low-tech retro holiday gift on my 2015 Holiday Gift wish! An Atari flashback with five classic games pre-loaded – Space Invaders®, Asteroids®, Battlezone®, Centipede®, Missile Command® and more. Looking at the box cover, I’m reminded of how those 80’s graphic designers seemed to be disconnected from the actual graphics capabilities of these early gaming consoles! Anyway, hopefully, if my children have listened to my copious hints, I’ll be playing Space Invaders with them over the holidays.” A lot has changed since 1995, the year that Avnet launched its first website, www.avnet.com. At the time, it was one of only 23,500 websites in existence. Today, there are more than one billion websites online and that number continues to grow. Not only has the volume of websites increased, but the way we access the Web has changed dramatically. Last year, Cisco predicted that the number of mobile-connected devices would exceed the world’s population by 2014. Cisco went on to predict that by 2018, over half of all devices connected to the mobile network will be “smart” devices and the vast majority of mobile data traffic (96 percent) will originate from these smart devices. In 1995, we definitely didn’t think anything like this was possible. Avnet.com homepage in 1995. Recently, we introduced a fresh, updated Avnet.com. Our new mobile-friendly site, allows visitors to get a better sense of what we do, who we help and who we are – on any device they choose. Throughout the years, Avnet has continuously made updates to our website as technology and needs have changed, but this has been a complete overhaul in look, feel and functionality. And we’ve done it all for you. Our site is designed to provide you with the information you seek quickly, as well as offering in-depth information about customers we’ve helped, unique services we offer and even career opportunities. The newly launched homepage of Avnet.com. As we approach our 20th year online, we hope that you’ll take a moment and visit the new Avnet.com. Tell us what you think on social media using the hashtag #AvnetWeb.Roses F.C. Roses F.C., of Detroit, Michigan, was an early twentieth century U.S. soccer team. History In 1910, Roses won the Michigan State Soccer Football League (MSSFL) championship. In 1917, Roses won the Michigan state championship. The next league result came in 1918 when Roses won the Detroit District League (DDL). In 1919, Roses won both the Michigan State Association Clan Campbell Trophy and the Detroit and District League championship. They repeated as DDL champions in 1922 and 1923. As for the National Challenge Cup, Roses entered every cup from the first in 1914 until at least the 1923 version. In 1914 Roses was eliminated in the third round. Its best year came in 1919 when they lost to Bricklayers and Masons F.C. in the quarterfinals. The team was active through at least the 1925-1926 season. Year-by-year Honors Clan Campbell Trophy Winner (1): 1919 League Championship Winner (5): 1914, 1918, 1919, 1922, 1923 References External links Photo of 1917 Michigan State championship team Category:Defunct soccer clubs in Michigan Category:Soccer clubs in DetroitFabregas puts ball in Barcelona's court by insisting he won't force move from Arsenal By Sportsmail Reporter Arsenal captain Cesc Fabregas said on Wednesday he was happy at the Premier League club and no decision had been made about a possible move. 'I am an Arsenal player. I have been very happy for eight years and I am very happy,' Fabregas said at a promotional event, when asked about the prospect of a return to Barcelona. 'I am not thinking about football right now, just about my holidays,' the 24-year-old Spain midfielder said, adding that questions about his future should be directed to Arsenal manager Arsene Wenger, to whom he had not spoken for six weeks. Old pals: Cesc Fabregas (right) left Barcelona's youth set-up as a teenager to join Arsenal 'There have been no decisions. The truth is that it doesn't always depend on the player and at the moment I don't know anything,' he added. 'I am very happy where I am. Anything else would be speculation that is untrue. You can never say never in this life as so many things happen that you can never predict.' Thumbs up: Fabregas insists he is not even thinking about football matters Spanish media have reported that European champions Barca would have to pay around £35million to secure Fabregas's services for next season. The player, who moved from Barcelona to London in 2003 at the age of 16, is seen as a natural replacement for playmaker Xavi, who turned 31 in January. Fabregas admitted he was frustrated at Arsenal's repeated failure to win a trophy but said he believed the club had the resources to end their barren run. 'A player who is not frustrated at not winning titles is either lying to himself or lacks ambition,' he said. 'There is a good team and a good manager and one of the most faithful fan bases in Europe. With those I believe we can make progress and one day win an important trophy.' Any decision on his future would be taken by Wenger, Fabregas added. 'He is the boss, the one who makes the decisions. You should ask him. I was injured at the end of the season and I haven't seen him for about six weeks.' Barcelona have spent more than a year trying to coax the Arsenal captain into going public with his desires, and their failure to meet Arsenal's valuation last summer left a bitter taste with a player who felt he had gone as far as he could to engineer the switch. Team player: Bacary Sagna (centre) has waded into the debate over team-mate Fabregas (left) The Spanish club also led a systematic campaign through national media agencies as well as Barcelona players to try and unsettle Fabregas and drive a wedge between him and the club's fans. The latest came when Barca skipper Carles
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*t**2 + t**5 - 2*t**5 + 2*t**5. -4*t**5 - 2*t**2 Expand (-3 + 4 - 2)*(19 - 15 - 18*m + 4*m). 14*m - 4 Expand (0 + 2 - 4)*(0 + 2*p**5 + 0) + 0*p**5 - p**5 - p**5 - 4*p**3 + 4*p**3 - p**5. -7*p**5 Expand 5*t**3 - 5*t**3 + 8*t**3 + t**3 + 2*t**2 + 4*t**3 - 3*t**3 + (-5*t**2 + t**2 + 2*t**2)*(0*t + 0*t - t). 12*t**3 + 2*t**2 Expand 2*d**5 - 3*d + 3*d + (31 - 12*d - 31)*(-5*d**4 + 2*d**4 + 4*d**4). -10*d**5 Expand (-2 + 2 + 2)*(121 - 121 - 4*j)*(2*j**2 - 2*j + 2*j)*(-4*j - 3*j + 6*j). 16*j**4 Expand (-6*r + 0*r - 3*r)*(4*r - 2 + 1 - 3*r). -9*r**2 + 9*r Expand (0 - 3*u + 0)*(-6*u**2 + 18 - 18) - 2*u**2 + u**3 + 2*u**2 - 5*u**3 + 3*u**3 + 3*u**3. 20*u**3 Expand -4*a - a + a + a - a - 2*a - 3*a - 3*a + 4*a - 2 + 2 - a + (2*a - 2*a - 2*a)*(1 + 2 - 2) - 4*a + 0*a + 2*a - a + 0*a + 3*a. -11*a Expand (0 + 0 + j + (2*j + j - j)*(0 - 2 + 0) - j - 3 + 3 + j + j - 4*j)*(-4 - 9*j + 4)*(0*j + 2*j + 0*j). 108*j**3 Expand (-2 - 6*v + 2)*(-3*v + 8*v - v). -24*v**2 Expand -4*v**2 + 3*v**2 + 0*v**2 + (-4 + 4 - 3*v)*(-5*v + v + 3*v). 2*v**2 Expand (3*g**2 + 2*g**2 - 2*g**2)*(4 + g - 4)*(3*g**2 - 4*g**2 - 4*g**2). -15*g**5 Expand (-5*p**2 + 2*p**2 + 2*p**2)*(-2 - p**2 + 2) + (-3*p**2 + 0*p**2 + p**2)*(-9*p**2 + 16 - 16 + (3*p - 4*p + 3*p)*(-2*p + 0*p + 0*p)). 27*p**4 Expand (2*j**4 + 2*j**4 - 6*j**4)*(-3*j + 0 - 1 - 1). 6*j**5 + 4*j**4 Expand (-2*z**4 - 2*z**3 + 2*z**3)*(0 + 8 + 1). -18*z**4 Expand (-2 + 4 + 0)*(3 - 4 + 3)*(-7*d**2 - 3*d**2 + 4*d**2). -24*d**2 Expand (-3 + 2*k + 3)*(k - k - 3*k**2) + (-4 - k**2 + 4)*(-k + 4*k + 2*k) - 4*k**3 + 4*k**3 - 2*k**3. -13*k**3 Expand (0 + 2 + 2)*(-7*r + 3*r + r). -12*r Expand (537*d - 537*d - 17*d**2)*(1 - 1 - d + (4 - 4 - 2)*(d + 0 + 0)). 51*d**3 Expand 3*i**4 + 0*i**2 + 0*i**2 + (3 - 5 + 3)*(-i**2 - 1 + 1)*(-6*i**2 + 3*i**2 + 4*i**2). 2*i**4 Expand ((d - d**2 - d)*(0*d + 3*d - 4*d) + (0*d**2 + 3*d**2 - 4*d**2)*(-d + 2 - 2))*(1 + 2 - 1). 4*d**3 Expand (0*a + a - 2*a + (a - a - 2*a)*(-2 + 2 - 1))*(-2*a**4 - 2*a**4 + 5*a**4). a**5 Expand (-5*n + 5*n - n)*(0 + 1 + 1 + (-2 - 1 + 1)*(-1 - 1 + 0) - 3 + 3 + 1). -7*n Expand (2 - 1 + 5)*(2*q**3 - q**3 + q**3)*(-1 - 2*q + 1). -24*q**4 Expand -2*p**2 - 2*p**2 + 2*p**2 + (9*p**2 - 2*p + 2*p)*(4 - 6 + 4). 16*p**2 Expand (2*m + 2*m - 8*m + (-m + 4*m - 2*m)*(-1 + 3 + 0))*(-2*m**2 + 3*m**2 + m**2). -4*m**3 Expand (3*k - k + 0*k)*(-k + 0*k - k)*(3*k**3 + 0*k**3 - 2*k**3). -4*k**5 Expand (18 - 22 - 19)*(0*z - z**4 + 0*z + (0*z**2 + 0*z**2 + 2*z**3)*(3*z - 3*z - 2*z)). 115*z**4 Expand -t**2 - t**2 - 14*t**2 + 0*t**2 - t**2 + 2*t**2 + (-t + t - 3*t)*(0 + 0 - t). -12*t**2 Expand (-5*s**3 + 5*s**3 - s**3)*(2*s - s + 3*s). -4*s**4 Expand -o**5 - 3*o**5 - 2*o**3 + 4*o**3 + (-3*o**4 + 2*o**4 + 0*o**4)*(0*o + 3*o + 18*o). -25*o**5 + 2*o**3 Expand -6*r + 31*r - 7*r + (2*r - 2*r + r)*(0 + 0 + 1). 19*r Expand (0*m - 3*m + 4*m)*(0 - 2 - 2) - 4*m - 5*m + 4*m. -9*m Expand (2*u + 0*u - 5*u)*(4*u + 5*u + 3*u) - u**2 + 4*u**2 - 5*u**2. -38*u**2 Expand (-4*z + z + z)*(0 + z**2 + 0) + 2*z**3 + 1 - 1 + (2*z + 0 + 0)*(-3*z**2 - z**2 + 2*z**2). -4*z**3 Expand (1 + 2 - 4)*(-2*t - 2 + 2)*(-5*t**2 + t**2 - 4*t**2)*(-t - t + t). 16*t**4 Expand 0 + 0 + 2*o + (0 + 3 - 4)*(-o + 3*o - 3*o) - 3*o - 2*o + 4*o - 31 + o + 31 + (2*o + 0 + 0)*(2 - 1 - 3). -o Expand -3 - 2*t + 3 - t + 3*t - t + (-3*t + 3*t - t)*(2 - 4 + 1) + 0 - 2*t + 0 + t + 0*t + 3*t. 2*t Expand -3 + o**4 + 3 + (o - o - o**3)*(-2 + 2 - 2*o) - 2*o**4 + 3*o**4 + 29*o**4. 33*o**4 Expand (-u + 6
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サービス。安心して使えるものはあるのか。偽アプリの運営会社で働く男性は「いまは『出会い系=さくら』みたいな印象も薄れてきた。ただし、匿名サービスの半分以上は偽アプリだ」という――。 ※本稿は、高野聖玄・セキュリティ集団スプラウト『フェイクウェブ』(文春新書)の一部を再編集したものです。 テレクラやダイヤルQ2が源流 通信技術を使った出会い系サービスの源流は、1980年代半ばにはじまったテレフォンクラブ(通称テレクラ)や、1989年にNTTが始めたダイヤルQ2(業者が電話を通じて提供する有料情報の料金を、NTTが通話料と一緒に回収するサービス。2014年2月にサービス終了)で提供されていた、見知らぬ男女が会話をするためのツーショットダイヤルにある。 その後、1995年にマイクロソフトからWindows 95が発売されたことを契機に日本でもインターネットが一般家庭まで普及しはじめ、その流れと合わせるように出会い系サービスもインターネット上に移行していく。サービスのあり方を大きく変えたのは、1999年2月にスタートした、NTTドコモが提供する携帯電話向けインターネット接続サービスiモードの登場だ。それまでの固定電話や固定インターネットを利用したサービスから、手軽に移動しながら利用できる携帯電話が登場したことで、携帯電話向けの出会い系サービスが急増。業者が荒稼ぎできる時代に入った。 出会い系バイトの時給は1100円位だった 2000年代前半に、出会い系サービスを運営する会社で働いていた30代後半の男性が振り返る。 「その会社は携帯電話向けの出会い系サービスを複数運営していましたが、実態はさくらを大量に雇ってユーザーに課金させるというものでした。登録者同士がメッセージをやり取りするにはポイントを購入しなければいけない仕組みで、例えば500円で50ポイント買って、受信したメッセージを開封するのに3ポイント、返信するのに5ポイントが支払われていくという感じです。で、ポイントがなくなったらまた買わせるように仕向けるというサイクルですね。 こっちとしては、登録ユーザーにいかにポイントを使わせるかが勝負なので、気を引く件名のメッセージを送って、いかに開封率を上げる(ポイントを使わせる)かに頭を使っていました。うまくやり取りに持ち込めれば、次はどれだけ話を引き伸ばして送受信の回数を増やすかです。 オフィスには常時数十人のアルバイトがいて、それぞれがパソコンを使って複数の相手とやり取りをするのですが、当時、出会い系サービスに登録しているユーザーの大半は男性だったので、さくらは女性ユーザーを装う形でした。その頃はまだ今のようにシステムも整備されていなかったので、各々が会話のテンプレートを作ってやり取りするようなやり方。品質はバラバラだったと思います。 アルバイトの時給は1100円位と当時の一般的な職種に比べて少し高いくらいで、自分がさくらを担当している登録ユーザーが課金すれば、その金額に応じて歩合が支払われる形態もありました。アルバイトの多くは、バンドマンとかヤンキーとかが多かった印象です。当時流行していたギャル系の10代の女の子なんかもいましたね。髪型や格好で面接を落とされることもないし、運営は24時間態勢なので、そういう人たちにとっては都合のいい仕事場だったからだと思います」Last June, NHS Chief of Staff Dr. Tom Stewart enlisted the services of an expert external review team of radiologists to oversee a review focusing on the work of one radiologist. The review involved 4,189 CT, MRI and mammography exams read by the radiologist between May 2014 and May 2015. The review was led by Dr. Brian Yemen, an external radiologist and a renowned leader in this area from McMaster University and Hamilton Health Sciences. A clinical review team made up of NHS physicians and nursing staff was also part of the review process, reviewing patients’ files and determining whether any follow-up care was required in the event any concerns were identified. The review found that after a rigorous assessment of the exams: There have been no deaths directly related to errors uncovered in the review. No mammography patients were impacted. Three patients - two who had CTs, and one who had an MRI - had a delay in diagnosis or treatment that impacted their health. Any additional patients identified as requiring potential follow-up care were also contacted, either directly or through their physician. All follow-up appointments at the hospital were expedited to care for these patients without delay, and a staff member supported them throughout the process. “We take our responsibility to provide patients with quality, safe care very seriously, and as a hospital we are committed to continuous learning and improvement,” says Dr. Stewart. “Quality reviews like these are important to ensure we are meeting the mark in every way.” There is no indication of the need to expand the timeframe of the review. Dr. Yemen wrote in the report that the review has achieved its purpose, and “it is unlikely that further investigation would provide a significant improvement to patient care.” NHS President Dr. Suzanne Johnston says: “We are deeply sorry for the worry we caused to patients in undertaking this review. I would like to express my appreciation to the community for its patience and understanding. I am very proud of the way our team came together on behalf of our patients and families. We worked very hard to ensure those in our care felt they were as well supported as could be throughout the process.” NHS has a number of quality assurance processes built into all aspects of our programs and services. This includes a peer review program in our Diagnostic Imaging department in which NHS radiologists randomly review each other’s readings as an added layer of quality control. This program was launched in July 2015 after a number of months of planning. Our community access line set up during the review will remain open for one week in the event members of the public have questions or concerns related to CT, MRI or mammography exams performed at NHS between May 2014 and May 2015. The direct number is 905-397-1905. The report from the external quality review is available in full here.Enhancement of the spin accumulation at the interface between a spin-polarized tunnel junction and a semiconductor. We report on spin injection experiments at a Co/Al2O3/GaAs interface with electrical
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still remember my dream And the man, the bees I can still remember my wild dream My cerebellum made And made me move through The best thing you can do is to leave me alone The best thing the Snake can do is to leave me alone I was quiet I wanted to be left alone I was quiet I wanted to be left alone I can be ferocious when I am not left alone Leave her alone he told me she is an old woman He told me, to leave her alone, she is an old woman Of course I would, she is Rangda Of course I would I told him The woman is Rangda She is my enemy, the worst demon of all Turning in on herself Turn in on yourself, faithful widow Electric snake, and wild blue hair Windows of light opening Into light that is faint yellow And then dark red And then full and material Material light That is ectoplasm Wretched face in the morning light O wretched face Teeth of the animal, and eyes of the self The best revenge Is to draw two things similar So that they are the same Core green and red Similar brain core What makes personality And the social Rangda is not the cortex of the brain But without her there is no revenge There is no enemy Without her there is no light No heavens No blue no red No green no yellow No sound Without Rangda There is no sound Heavy bells Heavy bellows from sky Without Rangda There are no bells nor sky Without Rangda, there is no sky How I started off When I was a young poet I started off loving the thing more than the people It took me a long time But then I loved the thing so much that I loved the people that made it What now? I love the people More than the thing I don't love words People love the things More They love the words more Like you You love the words more Hey hey Rangda Hey Rangda hey Reality You speak of one reality I speak of another Not alternate or surreal But one that is parallel or recurring Endlessly making one piece of me Into another thing You think of this world I am in the next I know the white world Where I have no eyes I know what it is like To float without space A jellied formless being That ceases to know time and context That is not condescending to the material But knows it is a one-sided line And that the infinite is a radiating set of lines And that we only walk around seamlessly On this one Death of the Polish empire I. I got sad when it happened The plane crash Down in a field of trees The trees the things that touched the wings The melting head, the fireball The thing landing as just a thing Poland is dead and I am not already I'd like to take this opportunity before I begin To thank the editors For including me in their anthology But I must also tell them That I do not want to be feminine anymore I am judiciously silent Until I have something important Really important to say About females—no I don't Drip, drop, about it I do not But not because it is not important Not because females are not important But because I really have nothing to say I am overwhelmed I am not grotesque, nor kitsch, nor cutesy I just went to the 7-Eleven and felt more Comfortable there than in the Whole Foods What does that say about me? It is not my birthday today, but I will die But maybe not in a plane crash But maybe not ever But maybe I will never die Oh you think not Oh you do not think so Oh what do you know Piercing gaze You read this poem I don't care if you are male or female What your age might be Where you are from I don't care I think it is all silly Your gaze is hot on my neck Telling me to write things Telling me that if I write things a certain way You may or may not Read them What or whom am I writing for? The Polish empire is dead today My father died six weeks ago I have no real anything to speak of I am not a body anymore when you read this What am I then I am what I was made visible. What am I then I am the word II. They say it happened because the pilots did not stop When they were supposed to The pilots were supposed to stop Because of the fog And that they instructed them to do so They say they instructed them to do so But that they could not insist They say they could not insist Oh what do they know Dumb pilots, they tried to land They were too low The fog blinded their sight Political figures Brutish pilots JFK Jr. in the open sea At night in fog To go sailing He got too low and flipped Dumb pilots, you are dead You got too low Your wings touched the trees You lost lift immediately, you crashed Almost 100 people died You died, too 100 people, But who were they The entire Roman, I mean Polish, Empire The entire Polish empire The entire regime died today I did not die It is all so far off, I know I know I know it is 2015 when you are reading this It is all so far off I know we are dead when we are reading this again I know it is all so far off I know The 20,000 people who were massacred Who they were flying the plane in To go, get out of, and commemorate the dead I know that those people Are far off, too Yes, I know When we are feeling fine When we wake up, read a poem like this one, Go back to sleep, or rise, Eat something, look out the window I know when we all seem fine That it is easy not to understand But you are one thing If you died The whole world would be less When 100 people die The world is less It is not ok When 20,000 people are murdered It is not ok When the woman in Florida accidentally Murders her baby it is not ok I am in this room I am in my coffin My father, a holy man In a coffin It is not ok When you think it is When you think other things are important When you make sex the important thing And not death Then I have no time for you When you live a life and write And believe that sex and gender are the defining things Then I have no time for you I will have nothing to say Death is what defines a poem The poem is dead Always dead You want to know what makes a poem special? It is dead Writing is there It is dead Horses are magical Planes fly The flowers are beautiful Writing is death The poem is dead It was always dead Respect poems Respect this poem It is dead And you are dead And I am dead And when we talk and kiss and eat We do it on a dead timeline Which is the history of the world Which is something like fate Which if we were only able to really understand We would know Is something more like physics III. I am tired now They say the flower died there before On the cursed land Let's look at the flower again Before we fade away The white flower Was born out of dew Parents who were water and air Two or three green bulbs The sun The air Would you like to think of its petals? They were white, with yellow flakes And also green In the fog you could see the yellow flakes Just before they burst into flames What else matters but the stage Nothing matters but the stage I don't do anything if not to show it off What
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Don't be discouraged if the prices seem out of reach right now. In the next few chapters, we'll not only show you how to save your money but how to make more, too. We don't just want you to plan your perfect day, but to plan _for_ your perfect day so that you can make it happen! As we mentioned earlier in the chapter, Katie and Nick realized when they did the Perfect Day exercise together that they'd previously underestimated how important it was to each of them to start their own family and to make sure they spent more quality time together, travelling and doing different activities. Both of them also wanted to take more steps to stay in shape by eating a healthier diet and by taking more classes in sports or activities that interested them. So they sat down together and came up with three goals they wanted to achieve over the next year: have a baby, take a three-week vacation to the Bahamas, improve their eating habits, and be more active. Then they did the necessary research to figure out how much it would cost to achieve them. They were comfortable using money they've already saved up to cover some of the costs—particularly, of having a baby (as they'd been diligently setting money aside for that for several months)—but they also wanted to try and cut their own expenses, or see how they could lower the costs of their goals, to save more money. Together, they were able to save a whopping $8,400. Here's how they did it: #### **KATIE AND NICK** **GOAL #1: HEALTH** Eat fresh, home-cooked meals at least four times per week, work out regularly at the gym, and take up at least one class or sport together each season. Estimated Cost: $415 per month or $4,980 per year. How _we_ came up with the price: We currently spend about $150 a week on frozen, prepackaged, or non-organic groceries. After comparing this to the prices of fresh fruits and vegetables and organic bread and meats, we estimated that it would cost at least another $50 a week to purchase those healthier ingredients. Katie also plans on taking two to three cooking courses a year, at an average of $60 per class, so that's an additional $180 a year (or $15 a month). In addition to the $50 per month we already pay for two gym memberships, we'd each like to register for at least one extracurricular class or sport each season—from soccer to snowboarding to yoga or carpentry. After researching the costs of taking lessons or classes and purchasing passes (for skiing), we estimate that we'll need about $100 each per month, on top of what we already pay for our gym memberships, for a total of $200 between us. How _we'll_ get it: Since we're planning on participating in more activities outside the home, we decided to switch to basic cable for just $60 per month, from the $150 we were paying for a bigger package, which will save us $1,080 per year. And we are going to sell our DVR, which should bring in another $200. Katie also reached out to a local yoga studio where she wants to take classes and offered to provide some marketing and PR services in exchange for free passes. These savings add up to $2,030—or about $169 per month—almost half the cost of activities. We'll draw the remaining $246 per month from savings we've already built up for short-term goals. **GOAL #2: FAMILY** We want to have a baby in the next year, and have enough savings to cover related expenses, including child care, as well as regular trips to see extended family. Estimated Cost: $1,866 per month (including child care) or up to $20,000 the first year. How _we_ came up with the price: After checking local and online baby stores, we've estimated the cost to furnish the baby's room and purchase clothes, toys, carriers, a stroller, and other accessories, at as much as $10,000 for the first year. Katie plans to stay home with the baby for six months, then we've estimated we'll need to spend about $1,000 per month on child care. (That's based on talking to friends who are parents as well as looking at local child care services.) By averaging the costs of airline tickets to see our families, we've estimated that we'll need to save about $4,000 the first year to be able to visit them as often as we'd like in the year after our baby is born. How _we'll_ get it: We are currently saving one of our salaries and using the other's to cover expenses. The money we save will primarily be used to cover the expenses related to starting a family. We've agreed that Katie will go back to work within six months of having a child. Since she is self-employed and has hardly any government assistance for maternity leave, she decided to return to work to be able to cover ongoing child care costs and afford to have additional income to visit family and friends out of town. **GOAL #3: Travel** We want to take a three-week vacation to the Bahamas over the holidays. Estimated Cost: $7,300. How _we_ came up with the price: Round-trip flights between Vancouver and Nassau can cost as much as $1,800 per person in peak season. We also discovered that the costs of accommodations can range from $150 to $500 per night. How _we'll_ get it: Katie has been saving up frequent flyer points and has enough now to cover one round-trip ticket to the Bahamas. That means we may need to fly separately, but we feel like that is a small price to pay for an estimated $1,800 in savings. We plan on booking the second flight early through a discount website like www.hotwire.com. We found that by taking two connecting flights, and travelling for an additional eight hours, we could save another $700 on Nick's flight—well worth the time! We are also planning on renting out our condo over the holiday season for at least part of the time we're away. We expect this will earn us an additional $800. And instead of staying in a hotel while we are in the Bahamas, we connected with some local expats who plan to head out of town for the holiday season, and they are letting us stay in their home for free—as long as we keep it clean and water the plants. Since we'll be staying in a home, we plan to eat more of our meals in, which we estimated should save us about $900 over those three weeks. Those savings, plus the extra earnings we plan to get from renting out our condo for a week, should cover about $6,200 of the original cost estimate we came up with. We'll use our savings to pay for the rest. There are a lot of ways you can both cut the cost of your goals and save more money to put towards them. In the next few chapters, we'll help you design a plan that's just right for you. Just remember: Setting money aside for those larger goals doesn't mean you can't have fun in the meantime. It's just a matter of prioritizing. Once you commit yourself to setting a certain amount of money aside for the longer-term goals that really matter to you, a funny thing happens: You'll find that short-term spending (that is, spending that yields little return in the long run) becomes less appealing. You'll both start looking at how you spend money in a whole new way, asking yourself—and maybe each other—if each of the purchases you make is really _worth_ your hard-earned money. Trust us. It will get easier to say no to things you don't really need, like a new flat-screen TV or another $100 pair of jeans, if you know that saying yes would mean waiting that much longer to reach your bigger goals. This does not mean that you can't splurge occasionally. It's just a matter of where you _want_ to put your money and when. ## Cut Costs Without Cutting Out the Fun If you're gourmands who love to sample the prix fixe menus at the top-rated restaurants in your area, then do it! Just make sure that dinners like that are an occasional treat and don't get in the way of your bigger goals. That's what Sandra and her boyfriend, Jason, have done. They agreed to eat at home most nights so they could save up and splurge on an occasional four-star meal to satisfy their foodie cravings. But if you both have dreamed about something bigger—say, taking a week-long cooking course in Tuscany—then you might decide to skip even the occasional five-course meal and simply sample an appetizer and a drink at the restaurant's bar. That way you can put the money you save towards your bigger goal (the tuition and trip to Tuscany), and make it happen sooner. If you're huge hockey fans, why not go in on a pair of season tickets with several friends so you can each go to a few games that season but spend a lot less? On those nights when you aren't watching the game live, you could organize a Hockey Night In, and invite other fans over to share a pizza or potluck dinner and watch the game together on TV. Imagine what you could do with the money you save? You might be able to buy a pair of play off tickets, if that's on your list
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(test_it) Output: running it asynchronously got 1 2 3 and ok it returned hey there ProcessPoolExecutor has a more limited API than multiprocessing.Pool, but if you don't need the more advanced features of multiprocessing.Pool, it's worth using because the integration is so much simpler. A: multiprocessing.Pool can be integrated into the tornado I/O loop, but it's a bit messy. A much cleaner integration can be done using concurrent.futures (see my other answer for details), but if you're stuck on Python 2.x and can't install the concurrent.futures backport, here is how you can do it strictly using multiprocessing: The multiprocessing.Pool.apply_async and multiprocessing.Pool.map_async methods both have an optional callback parameter, which means that both can potentially be plugged into a tornado.gen.Task. So in most cases, running code asynchronously in a sub-process is as simple as this: import multiprocessing import contextlib from tornado import gen from tornado.gen import Return from tornado.ioloop import IOLoop from functools import partial def worker(): print "async work here" @gen.coroutine def async_run(func, *args, **kwargs): result = yield gen.Task(pool.apply_async, func, args, kwargs) raise Return(result) if __name__ == "__main__": pool = multiprocessing.Pool(multiprocessing.cpu_count()) func = partial(async_run, worker) IOLoop().run_sync(func) As I mentioned, this works well in most cases. But if worker() throws an exception, callback is never called, which means the gen.Task never finishes, and you hang forever. Now, if you know that your work will never throw an exception (because you wrapped the whole thing in a try/except, for example), you can happily use this approach. However, if you want to let exceptions escape from your worker, the only solution I found was to subclass some multiprocessing components, and make them call callback even if the worker sub-process raised an exception: from multiprocessing.pool import ApplyResult, Pool, RUN import multiprocessing class TornadoApplyResult(ApplyResult): def _set(self, i, obj): self._success, self._value = obj if self._callback: self._callback(self._value) self._cond.acquire() try: self._ready = True self._cond.notify() finally: self._cond.release() del self._cache[self._job] class TornadoPool(Pool): def apply_async(self, func, args=(), kwds={}, callback=None): ''' Asynchronous equivalent of `apply()` builtin This version will call `callback` even if an exception is raised by `func`. ''' assert self._state == RUN result = TornadoApplyResult(self._cache, callback) self._taskqueue.put(([(result._job, None, func, args, kwds)], None)) return result ... if __name__ == "__main__": pool = TornadoPool(multiprocessing.cpu_count()) ... With these changes, the exception object will be returned by the gen.Task, rather than the gen.Task hanging indefinitely. I also updated my async_run method to re-raise the exception when its returned, and made some other changes to provide better tracebacks for exceptions thrown in the worker sub-processes. Here's the full code: import multiprocessing from multiprocessing.pool import Pool, ApplyResult, RUN from functools import wraps import tornado.web from tornado.ioloop import IOLoop from tornado.gen import Return from tornado import gen class WrapException(Exception): def __init__(self): exc_type, exc_value, exc_tb = sys.exc_info() self.exception = exc_value self.formatted = ''.join(traceback.format_exception(exc_type, exc_value, exc_tb)) def __str__(self): return '\n%s\nOriginal traceback:\n%s' % (Exception.__str__(self), self.formatted) class TornadoApplyResult(ApplyResult): def _set(self, i, obj): self._success, self._value = obj if self._callback: self._callback(self._value) self._cond.acquire() try: self._ready = True self._cond.notify() finally: self._cond.release() del self._cache[self._job] class TornadoPool(Pool): def apply_async(self, func, args=(), kwds={}, callback=None): ''' Asynchronous equivalent of `apply()` builtin This version will call `callback` even if an exception is raised by `func`. ''' assert self._state == RUN result = TornadoApplyResult(self._cache, callback) self._taskqueue.put(([(result._job, None, func, args, kwds)], None)) return result @gen.coroutine def async_run(func, *args, **kwargs): """ Runs the given function in a subprocess. This wraps the given function in a gen.Task and runs it in a multiprocessing.Pool. It is meant to be used as a Tornado co-routine. Note that if func returns an Exception (or an Exception sub-class), this function will raise the Exception, rather than return it. """ result = yield gen.Task(pool.apply_async, func, args, kwargs) if isinstance(result, Exception): raise result raise Return(result) def handle_exceptions(func): """ Raise a WrapException so we get a more meaningful traceback""" @wraps(func) def inner(*args, **kwargs): try: return func(*args, **kwargs) except Exception: raise WrapException() return inner # Test worker functions @handle_exceptions def test2(x): raise Exception("eeee") @handle_exceptions def test(x): print x time.sleep(2) return "done" class TestHandler(tornado.web.RequestHandler): @gen.coroutine def get(self): try: result = yield async_run(test, "inside get") self.write("%s\n" % result) result = yield async_run(test2, "hi2") except Exception as e: print("caught exception in get") self.write("Caught an exception: %s" % e) finally: self.finish() app = tornado.web.Application([ (r"/test", TestHandler), ]) if __name__ == "__main__": pool = TornadoPool(4) app.listen(8888) IOLoop.instance().start() Here's how it behaves for the client: dan@dan:~$ curl localhost:8888/test done Caught an exception: Original traceback: Traceback (most recent call last): File "./mutli.py", line 123, in inner return func(*args, **kwargs) File "./mutli.py", line 131, in test2 raise Exception("eeee") Exception: eeee And if I send two simultaneous curl requests, we can see they're handled asynchronously on the server-side: dan@dan:~$ ./mutli.py inside get inside get caught exception inside get caught exception inside get Edit: Note that this code becomes simpler with Python 3, because it introduces an error_callback keyword argument to all asynchronous multiprocessing.Pool methods. This makes it much easier to integrate with Tornado: class TornadoPool(Pool): def apply_async(self, func, args=(), kwds={}, callback=None): ''' Asynchronous equivalent of `apply()` builtin This version will call `callback` even if an exception is raised by `func`. ''' super().apply_async(func, args, kwds, callback=callback, error_callback=callback) @gen.coroutine def async_run(func
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on it and we only spent two nights in it. The only difference from the pictures is that my tra... Take all the features of the very popular 1685, including a complete dry bath, large kitchen counter space, Lance exclusive U-shaped &quot;Super Slide&quot; dinette and add a forward queen-sized walk around bed, and you get the 1995! With a dry weight of 4,080 pounds and GVWR of 5,700 pounds, most full size SUV&#039;s and pick up&#039;s make perfect tow vehicles. &lt;br&gt;&lt;P&gt;The designer...CIA Director Mike Pompeo has said he hasn’t seen any evidence of Russian interference in the US election, but that the Trump administration took the allegations very seriously. During his first interview with CBS News at CIA headquarters, Pompeo was asked whether he had seen any evidence of collusion between members of the Trump campaign and Russian officials. “I wasn’t on the campaign,” Pompeo replied. “I haven’t seen it.” “I can only say this: I’ve watched this administration deal with all of our adversaries in a way that has been robust. The CIA, as part of that, is doing our part,” he added. .@CIA Director Mike Pompeo on PDB: “It's absolutely important that we deliver information to the President in a way that in the time that can be allotted to this, that he can grasp the central information that we're trying to deliver to him.” Only on @CBSThisMorningpic.twitter.com/9XMRbnanL7 — Norah O'Donnell🇺🇸 (@NorahODonnell) January 22, 2018 President Donald Trump has repeatedly said that allegations of his campaign colluding with Russia were “fake news” and a “total hoax.” Most recently, he excoriated the mainstream media on his Twitter page on January 16. "Do you notice the Fake News Mainstream Media never likes covering the great and record setting economic news, but rather talks about anything negative or that can be turned into the negative," Trump tweeted Tuesday. "The Russian Collusion Hoax is dead, except as it pertains to the Dems. Public gets it!" Do you notice the Fake News Mainstream Media never likes covering the great and record setting economic news, but rather talks about anything negative or that can be turned into the negative. The Russian Collusion Hoax is dead, except as it pertains to the Dems. Public gets it! — Donald J. Trump (@realDonaldTrump) January 16, 2018 The reference to the Democratic Party presumably applies to the alleged wrongdoing on the part of Hillary Clinton in approving a uranium deal with a Russian company. Pompeo said allegations of Russian interference in American democracy were being taken seriously, adding, “ I wish it had been taken this seriously previously.” Read more CBS said it was former CIA director John Brennan who reportedly alerted the FBI to contacts between Russian officials and the Trump campaign, a central focus of the ongoing investigation. As to what steps were being taken to counter interferences in 2018 and in the next presidential election in 2020, Pompeo was somewhat vague. “It's a very important question. I can't answer it,” said the spymaster. “I can only tell you this: There is a major push, not only from the CIA but all of this administration, this government, to do everything we can to prevent that from happening in 2018, in 2020, in 2030, and beyond." The former Republican congressman from Kansas said he was ringing the changes at the spy agency. “We are doing things today that the CIA was not doing a year ago, and there's more risk attached to those," Pompeo said. He confirmed that this meant expanding US covert and clandestine operations, as “almost certainly, I want the president to have the best intelligence in the world.” Asked about what kind of legacy he wanted to leave, Pompeo was emphatic: “I think our adversaries should know this when Mike Pompeo leaves as the director of the CIA, this organization will be more vicious, more aggressive, more inclined to take risks to come directly at the threats that America and the world faces. If I do that I will be very proud.”1982 Wailea Pro Tennis Classic The 1982 Wailea Pro Tennis Classic, also known as the Hawaii Open, was a men's tennis tournament played an outdoor hard courts in Maui, Hawaii, in the United States that was part of the 1982 Volvo Grand Prix circuit. It was the ninth edition of the tournament and was held from September 27 through October 3, 1982. Unseeded John Fitzgerald won the singles title. Finals Singles John Fitzgerald defeated Brian Teacher 6–2, 6–3 It was Fitzgerald's 1st singles title of the year and the 2nd of his career. Doubles Eliot Teltscher / Mike Cahill defeated Francisco González / Bernard Mitton 6–4, 6–4 References Hawaii Open Category:1982 in Hawaii Category:1982 in American tennis# @textcomplete/core > Core of Textcomplete [![npm version](https://badge.fury.io/js/@textcomplete%2Fcore.svg)](http://badge.fury.io/js/@textcomplete%2Fcore) ## License &copy; Yuku Takahashi - This software is licensed under the MIT license. <!-- ====================================================================== --> <!-- Simplified DocBk XML Information Pool V3.1.7.1 Part of the Simplified DocBk XML V3.1.7.1 DTD http://nwalsh.com/docbook/simple/ See COPYRIGHT for more information Please direct all questions and comments about this DTD to Norman Walsh, <[email protected]>. --> <!-- ====================================================================== --> <!ENTITY % local.component.mix ""> <!ENTITY % component.mix "%list.class; |%admon.class; |%linespecific.class; |%para.class; |%informal.class; |%formal.class; |%compound.class; |%descobj.class; %local.component.mix;"> <!ENTITY % local.sidebar.mix ""> <!ENTITY % sidebar.mix "%list.class; |%admon.class; |%linespecific.class; |%para.class; |%informal.class; |%formal.class; %local.sidebar.mix;"> <!ENTITY % local.qandaset.mix ""> <!ENTITY % qandaset.mix "%list.class; |%linespecific.class; |%para.class; |%informal.class; |%formal.class; %local.qandaset.mix;"> <!ENTITY % local.footnote.mix ""> <!ENTITY % footnote.mix "%list.class; |%linespecific.class; |%para.class; |%informal.class; %local.footnote.mix;"> <!ENTITY % local.example.mix ""> <!ENTITY % example.mix "%list.class; |%linespecific.class; |%para.class; |%informal.class; %local.example.mix;"> <!ENTITY % local.highlights.mix ""> <!ENTITY % highlights.mix "%list.class; |%admon.class; |%para.class; %local.highlights.mix;"> <!ENTITY % local.para.mix ""> <!ENTITY % para.mix "%list.class; |%admon.class; |%linespecific.class; |%informal.class; |%formal.class; %local.para.mix;"> <!ENTITY % local.admon.mix ""> <!ENTITY % admon.mix "%list.class; |%linespecific.class; |%para.class; |%informal.class; |%formal.class; %local.admon.mix;"> <!ENTITY % local.figure.mix ""> <!ENTITY % figure.mix "%linespecific.class; |%informal.class; %local.figure.mix;"> <!ENTITY % local.tabentry.mix ""> <!ENTITY % tabentry.mix "%list.class; |%admon.class; |%linespecific.class; |%para.class; |mediaobject %local.tabentry.mix;"> <!ENTITY % local.glossdef.mix "">
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while the added aerobic opportunity is a plus, the inconvenience associated in saving a few pennies, is not. I'd only do it if I knew I could save at least $20 a week, so for the 14 days in July that I would be travelling round trip to work, the cost of gasoline would need to be $7.67 per gallon. And if that happens, I think we'd have a lot of other things to have to worry about. My spreadsheet is nothing overly fancy, but if anyone is interested in it, drop me a line and I'll be happy to email it to you. My ex informed me that their my kids photos came in (school & baseball). Gee, let's take a look: Tonight was my son's last baseball game for the season. The pizza took longer to arrive than the length of their game. Ugh. Here he is scoring a run in the final game tonight: I always like to read Runner's World as well as Running Times for advice and help on how to perform better. There was an interesting article posted in the July 2008 edition of Runner's World about Finishing Strong. Always feeling grateful for finishing off with a good kick, I had to read it, and was very surprised by what they said. First off, the article did not delve into outsprinting anyone in the last 100 meters. Instead, it talked about how to be strong in the last third of your race. The author, who is also a coach invented FiST points. It is a statistic that he uses to track his runners during their cross-country season. Using a video camera that records each team member's place at two-thirds of the way into a race, these FiST ("FInish STrong") points, are earned like this. 1 point for every runner you pass, -1 for every runner that passes you. Runners with a few points at the end of a season mayhave been going out too fast. On the flip side, runners with tons ofpoints leave too much for the last third and could improve their times bypushing a little harder earlier. The ideal is to start out a fastpace that you can sustain for the distance, with enough reserve to push pastslowing competitiors near the finish. - Ed Eyestone I agree with all this, but I sometimes find it challenging to keep a correct head count at the end of a race, especially if I'm going all out. All I can think of counting are the number of bagels I am planning to gorge myself with as soon as that damn obedience timer is taken off my show. Finally (and alas), my Dad and I got into a laborious debate on IM over, of all things, the direction that my sneakers are pointed and rotating on the top of my blog. The ending of which, was a killer: DAGONAZ [10:22 P.M.]: I suggest you have the sneakers in your blog run forward.AlexGonzalez0709 [10:22 P.M.]: ???DAGONAZ [10:23 P.M.]: you din't notice?DAGONAZ [10:23 P.M.]: didn't?AlexGonzalez0709 [10:23 P.M.]: the sneaker wheel is going clockwise. you want me to make it counter clockwise?DAGONAZ [10:24 P.M.]: the sneakers are going backwards!AlexGonzalez0709 [10:24 P.M.]: the sneakers are landing on the bottom as the normal foot doesDAGONAZ [10:25 P.M.]: i don't think you understand me or i am not makingmyself clear. When I see your blog the sneakers are running backwards!AlexGonzalez0709 [10:25 P.M.]: no they are not.DAGONAZ [10:25 P.M.]: yes they are!AlexGonzalez0709 [10:25 P.M.]: when you run. your foot lands,and after it lands, it lifts and goes backAlexGonzalez0709 [10:25 P.M.]: if i make it go counter clockwise it's going to look horrible.DAGONAZ [10:26 P.M.]: i dont know what you are saying. THE SNEAKERS ARE RUNNING BACKWARDS! That's the way i see it here. I swear!DAGONAZ [10:27 P.M.]: they are circulating backwards!DAGONAZ [10:29 P.M.]: your sneakers are still running in a circle backwardsAlexGonzalez0709 [10:29 P.M.]: bullshit!DAGONAZ [10:30 P.M.]: i swear!AlexGonzalez0709 [10:30 P.M.]: what is frontwards to you then?DAGONAZ [10:30 P.M.]: please chek it outAlexGonzalez0709 [10:30 P.M.]: u didnt answe my questionDAGONAZ [10:30 P.M.]: the front of the foot should move forward not backwardsAlexGonzalez0709 [10:30 P.M.]: in a wheel the foot motion would not look natural that wayAlexGonzalez0709 [10:31 P.M.]: i got it. stand up. look at your motionDAGONAZ [10:31 P.M.]: whatever. ask any of your other readers.AlexGonzalez0709 [10:31 P.M.]: actually i got one better. cover the top half of the wheel.AlexGonzalez0709 [10:31 P.M.]: now look at it.AlexGonzalez0709 [10:31 P.M.]: the motion is correctAlexGonzalez0709 [10:31 P.M.]: feet land in front then go backDAGONAZ [10:31 P.M.]: still running backwards! ASK SOMEONE ELSE!AlexGonzalez0709 [10:31 P.M.]: you are not readingAlexGonzalez0709 [10:31 P.M.]: and yes i am listeningAlexGonzalez0709 [10:32 P.M.]: cover the top half of the circle . look at what im getting at.AlexGonzalez0709 [10:32 P.M.]: tell you what. let me placate you. i will change it now in photoshop. do you have a few minutes?AlexGonzalez0709 [10:32 P.M.]: 5 minutes.DAGONAZ [10:33 P.M.]: i did and the whole circular movement, which is clockwise, shows the sneakers backwards!DAGONAZ [10:33 P.M.]: the movement is correct, clockwise, but the sneakers are placed backwards!AlexGonzalez0709 [10:33 P.M.]: what do you mean by backwards placement?AlexGonzalez0709 [10:34 P.M.]: should the sneaker at the bottom be upside down, and at the top be right side up, going clockwise?DAGONAZ [10:34P.M.]: if the movement is clockwise, the sneakers should have the point looking clockwise, not backwardsAlexGonzalez0709 [10:34 P.M.]: read my last line and answerDAGONAZ [10:35 P.M.]: all the sneakers should be pointing clockwise with their front part. that's my answerAlexGonzalez0709 [10:35P.M.]: you mean pointing to the right.DAGONAZ [10:35 P.M.]: yesAlexGonzalez0709 [10:36 P.M.]: well then i could do that. however the circular motion will not be as fluid because every sneaker would be at a flat 0degreesDAGONAZ [10:36 P.M.]: take the sneakers and shove them up your ass!LOL And there you have it folks. And some people wonder why I'M so dysfunctional....DNA my friends.....D - N - A !!! Let's take a straw poll. I've put a poll on the right hand side of the page. Please vote. This will help me know whether I've lost it or not (well, we know I probably have lost it), and whether the sneakers are going backwards or not. Sunday, June 22, 2008 After icing my leg for hours last night, and this morning, I ran a lot longer than I thought I could, and successfully completed my second long run of the week. It started out with a longer-than-expected conference call to Germany this morning. I was all suited up and ready to go, but did not hit the streets until around 7:15 in the morning. I ran up to the Queens Center Mall, and returned, heading straight for the starting line. I already knew it would be impossible to meet the group on time, but figured I would run into someone along the course. And I did.I met up with Scott on Forest Park Drive not far from Metropolitan Avenue. I turned around and ran with him back to the finish, and took a short break. Met Lori, Barbara, Tom & Tom there too. When Scott left, so did I. First I did 4 laps around Victory Track and then headed back into the park. Somewhere near the Pine Tree
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uer, who said that in the recent WBO convention, it was decided that Melindo will face the winner of the title unification bout between Viloria and Hernan "Tyson" Marquez. Viloria knocked down Marquez three times in their fight last Saturday in Los Angeles en route to a tenth round technical knockout victory. Melindo currently holds the WBO's 'international' flyweight title. Meanwhile, Viloria also annexed the World Boxing Association belt after beating Marquez. "(We have to) start the negotiations within 30 days and by next week, we will most probably send a letter to the camp of Viloria and see what their plans are," Aldeguer told Nathanielsz. Viloria was non-committal about his future plans, saying that he plans to rest first. Nathanielsz reported that it is possible that Viloria may give up the WBO belt instead of defending it against a fellow Filipino. He may instead take on light-flyweight champion Roman "Chocolatito" Gonzales of Nicaragua.Q: how to put a button beside a dropdownlist in asp.net properly? i have dragged a (dropdownlist) and i try to add a button beside it, in the design view it is beside the (dropdownlist) but when i run it, i see a more than five space between them see the below code. i don't know what to do actually. i have tried to put them into a table one row with two columns but the space between them is quite a lot. i only want one space between them <asp:DropDownList ID="DropDownList1" runat="server" Height="16px" Width="280px"> </asp:DropDownList> <asp:Button ID="Button1" runat="server" Text="Button" /> in design view in run mode A: Thank you all who have tried or wants to try answering this question by seeing the title the problem with that is because i was given the (dropdownlist) CssClass="form-control" and it was not allowing the butten to be close to it resulting in giving it a few spaces by changing the CssClass from (form-control) to CssClass="dropdown"), it solved my problem Did you know you can support Fibromyalgia Support for Surrey and Sussex (FMSSAS) every time you shop online - at no cost to you? With ‘Give as you Live’ thousands of brands including Play.com, John Lewis and Expedia have signed up to donate a percentage of every purchase you make online to us. All at no cost to you and at no cost to us. Simply visit http://www.giveasyoulive.com/join/fmssas and discover ‘Give as you Live’ today. If you sign up by 31st March 2012 ‘Give as you Live’ will donate an additional £5 to us after you spend £10 or more. ICIS can help you! We gather information about support, care and advice services, suppliers, clubs and activities in West Sussex. We can help you find services, groups and opportunities to help you maintain your health, wellbeing and independence. Contact our Enquiry Line and we will search our West Sussex and national databases and reference library to find you help. Or search the ICIS Wellbeing & Community Directory (an extract of our full Directory) to find day-to-day help. ICIS can help you find services you may not know exist. Pre-booking is essential if you wantto attend the largest annual voluntary sector event in East Sussex onTuesday 13 Marchat the Winter Gardens, Eastbourne, from 9.40am to 2.30pm. What will 2012 bringfor voluntary and community groups? How will groups be affected by recent changes to national policy? What will be gained and what will be lost? The event will focus on changes to Health and Social Care, and Welfare and Legal Aid. The Big Event 2012 will feature local and regional speakers, a Q&A session and discussion groups. There will also be an advice fair offering information about free and low-cost services for organisations (including IT support, training and funding advice). Is your fibromyalgia becoming more unmanageable and is staying awake during the day a constant struggle? Both of these situations can make you wonder, “What can I do to get out of this rut?” Two experienced clinicians describe common reasons for why fibro symptoms can worsen and offer their treatment advice to help you get back on your feet. If you're suffering with fibromyalgia, there's a good chance you might also be having a difficult time enjoying a good night's sleep. Those who have fibromyalgia report a wide range of sleep difficulties, including a hard time getting to sleep, continual awakening throughout the night, as well as sleep apnea (characterized by abnormal breathing) and restless leg syndrome (an overwhelming urge to move the legs). More than 30 million Americans suffer with migraine headaches, and most are women. Although doctors aren’t sure what causes all of them, they suspect more than a quarter of migraine sufferers have specific food triggers. To find out if a particular food is causing your headache, keep a diet diary for at least a month and pay special attention to the most common food triggers. Read more:- Migraines and other types of headache - such as tension headache and sinus headache - are painful and can rob you of quality of life. Migraines affect around 15% of adults in the UK. Migraine symptoms include a pounding headache, nausea, vomiting and light sensitivity. Headache remedies include various types of pain killers. Migraine treatments may also include anti-sickness drugs and medications to prevent or stop headaches. We know that diet/nutrition plays an important role is some chronic pain conditions. For example with migraine sometimes just changing your diet may resolve the problem. Another condition, gout (high uric acid levels) can also be triggered or exacerbated by some foods and alcohol. In this discussion I want to share some results I discovered on the role of Vitamin D and some chronic pain conditions. In a recent issue of Arthritis Research & Therapy, Ribeiro and colleagues [1] present data that lend further support to the theory that women with fibromyalgia (FM) suffer from autonomic dysfunction in response to, and during recovery from, acute exercise. Alterations in autonomic function have been suggested to increase the risk for cardiovascular events and mortality [2]. While the data are not fully understood regarding the risk of premature cardiovascular disease in women with FM specifically, it appears that there is definitive evidence to support autonomic dysfunction at rest. The more I try to learn about the cause of fibromyalgia, the more I just get confused. Some sources say it's caused by autoimmune diseases, some say it's hereditary, some say it's because of a virus or a neck injury or diet or chronic stress, and recently someone told me it's caused by depression. What really is the cause of fibromyalgia? N.B. I would like to point out to you all that the information in my eNewsletters does not necessarily infer endorsement by the charity Fibromyalgia Support for Surrey & Sussex. Any advice or recommendation of a medical or legal nature must always be discussed with a qualified professional. The charity cannot be held responsible for omissions and/or errors. Sites I refer you to are for information only. They might conflict in their opinions, they might not even be medically sound, but I merely offer them for you to peruse and make your own judgements, accept or reject as you will. Only by reading widely can we get an overall picture of fibromyalgia syndrome and how we can deal with its symptoms, learn to cope with them and still have a life. I also include various awareness and local issues as well as general health considerations.Anyone wishing to reproduce any of the above items in printed form should seek permission from the originators. About Me I am a FMS survivor having been diagnosed in 2003. I have worked, on a voluntary basis, in many capacities since 2004 with the charity Fibromyalgia Support for Surrey and Sussex. I aim to post an eNewsletter (eNews) every week, usually on a Saturday giving links to information about fibromyalgia and related subjects, general health issues, health service and government plans, social benefits, therapies, books, ebooks, etc. etc. I also maintain the website www.fms-sas.co.uk, am leader of the Horsham Support Group and am a trustee of the charity. As well as all this I am Assistant Regional Co-ordinator for Surrey and Sussex for the Fibromyalgia Association UK (FMA UK).Q: How to tune Vim Perl 6 syntax highlighting to de-emphasize sigils? I'm using vim-perl6 for syntax highlighting, but I'd like to adjust the color of variable sigils so that they are less standout. Perhaps, make them look pale or something. How do I do that? Thanks. A: Comment out the line: HiLink p6Variable Identifier in perl6.vim Modify the colorscheme file I use (in my case, on MacOS, I copied it from /usr/share/vim/vim80/colors/ to ~/.vimrc/colors/), and add to it: hi p6Variable ctermfg=darkgrey hi p6Variable guifg=darkgrey Bsnl UDP Trick Confrim Working In South States Here is
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you didn’t stressed out the main concept: the change of legs. First, the non-jumping leg goes up obviously, then the jumping leg lifts to that level too, and after a little stall, the non-jumping leg lands on the floor. Good job anyways 😉 School Sports Tricking Disclaimer The technical skills described in this site should be performed if, and only if, you have the physical mobility and psychological stability needed to do so. Consultation with a doctor and/or physical fitness instructor is recommended prior to attempting these techniques if any doubts exist. Doing so after you have had an accident would ruin the purpose of the consultation. By entering/viewing this site you, and any you teach, agree that you/they will not hold the creator of this site, the ISP, or any affiliated entity responsible.--- abstract: 'We review existing methods for implementing smooth functions $f(A)$ of a sparse Hermitian matrix $A$ on a quantum computer, and analyse a further combination of these techniques which has some advantages of simplicity and resource consumption in some cases. Our construction uses the linear combination of unitaries method with Chebyshev polynomial approximations. The query complexity we obtain is ${{\mathcal{O}}}(\log C/\epsilon)$ where $\epsilon$ is the approximation precision, and $C>0$ is an upper bound on the magnitudes of the derivatives of the function $f$ over the domain of interest. The success probability depends on the $1$-norm of the Taylor series coefficients of $f$, the sparsity $d$ of the matrix, and inversely on the smallest singular value of the target matrix $f(A)$.' author: - 'Sathyawageeswar Subramanian$^1$[^1]' - Steve Brierley$^2$ - Richard Jozsa$^1$ title: Implementing smooth functions of a Hermitian matrix on a quantum computer --- Introduction ============ There are many quantum algorithms that exhibit an advantage over known classical algorithms[^2]. Such a diversity of results can make it difficult to express the computational capability of a quantum computer in a clear and faithful manner to someone new to quantum computing. Here we address a large family of quantum algorithms that are often used as the main subroutine in many important applications. In particular we consider quantum algorithms that apply some smooth function of a Hermitian matrix to an input state. Examples of algorithms of this type include Hamiltonian simulation used in a variety of applications including quantum chemistry, the Quantum Linear Systems or matrix inversion algorithm [@Harrow2009QuantumEquations; @Childs2015] used in quantum machine learning applications, and sampling from Gibbs distributions used in the recent quantum semi-definite programming (SDP) solvers [@Brandao2017ExponentialLearning; @vanApeldoorn2017QuantumBounds]. In addition to briefly reviewing the methods for implementing matrix functions $f(A)$ used in these algorithms, we further use one of them to obtain an algorithm with query complexity expressed simply in terms of properties of the matrix $A$ and the Taylor expansion of $f$. Restricting to Hermitian matrices allows one to take advantage of their spectral decomposition to naturally extend results on approximating real functions to functions of matrices. Thus, for a real valued smooth function $f$, we look for a quantum algorithm which, when equipped with a quantum oracle for a Hermitian matrix $A$ and a map that prepares some state $\ket{x}$, returns a state that is close to $\frac{f(A)\ket{x}}{{\left\|{f(A)\ket{x}}\right\|}}$ in $l_2$-norm. If measurements are involved, we require the desired output state to be obtained with high probability. Among the earliest work of this kind, Klappenecker and Rötteler [@Klappenecker2003EngineeringAlgorithms] studied the implementation of functions of unitary matrices, under some mild assumptions. This work embodies the same principles and ideas that were later developed into a method for Hermitian matrices in works of Berry, Childs, Kothari and collaborators. Other early work in this direction was motivated by studies on Hamiltonian simulation (for example, [@Somma2002SimulatingNetworks] and [@Childs2012HamiltonianOperations]), and algorithms for quantumly solving ordinary differential equations (for example, [@Leyton2008AEquations] describe a method to implement non-linear transformations of the amplitudes of a given input state). Kothari [@Kothari2014EfficientComplexity] gives a detailed description of probabilistic implementations of operators and technical lemmas on modified versions of amplitude amplification. Broadly, three different methods have emerged to realise the action of functions of Hermitian matrices on a quantum computer: 1. Using Hamiltonian simulation and Quantum Phase Estimation (QPE) as a technique to obtain a representation of the target state in the spectral basis of the matrix, followed by applying a suitably engineered unitary that computes the matrix function. This is the method used in the matrix inversion algorithm of [@Harrow2009QuantumEquations] and in the quantum recommendation systems algorithm of [@Kerenidis2016QuantumSystems]. 2. By representing the target matrix as a Linear Combination of Unitaries (LCU). Given an algorithm to implement each of the unitaries in the summation, the target matrix can be embedded in a unitary operation on a larger state space (adjoining the necessary ancillary qubits). This necessitates a post-selection step at the end, and so produces the required state with some associated success probability. This method has been used widely for Hamiltonian simulation and matrix inversion algorithms [@Childs2012HamiltonianOperations; @Berry2015SimulatingSeries; @Childs2015]. 3. More recently, Low and Chuang [@Low2016] have introduced a method called Qubitization and Quantum Signal Processing (QSP) (also referred to as the block-encoding method). They study how to implement functions of a diagonalisable complex matrix when provided with a unitary oracle and a signal state such that the action of the unitary on the subspace flagged by the signal state is proportional to the action of the target matrix. This method is thought to have optimal query complexity and optimal ancilla requirements for a large class of functions. This method has been substantially expanded and generalised to what has been termed Quantum Singular Value Transformation in a recent article of Gilyén et. al. [@GSLW2018]. Typically, these methods have been applied to a specific function or application such as Hamiltonain simulation. The question of whether there exisits a more general result for an arbitrary function $f$ is very natural. Recently, van Apeldoorn et. al. [@vanApeldoorn2017QuantumBounds] used the Linear Combination of Unitaries or LCU method [@Childs2015] with an approximation by Fourier series to provide a constructive approach for the implementation of bounded smooth functions of a $d-$sparse Hermitian matrix (specified by an oracle) on quantum computers. They give an algorithm for constructing the approximating linear combination, and their quantum algorithm has query complexity linear in the sparsity $d$. This method uses Hamiltonian simulation as a black-box subroutine and involves converting the Taylor series of the function into a Fourier series, through a sequence of approximation steps. Both [@Low2016] and [@GSLW2018] also prove theorems about the classes of functions their methods can implement and describe the approach to construct the implementation for important examples like Hamiltonian simulation. In this article, we first review the spectral method, the LCU method, and Qubitization in sections \[sec:HHL\_method\], \[sec:QLSA-lcu\], and \[sec:qubitization\] respectively. We then give an alternative constructive approach for implementing smooth functions of a Hermitian matrix on a quantum computer in section \[sec:LCU\_Chebyshev\], based on the method of Chebyshev polynomial approximations used for matrix inversion in [@Childs2015]. The complexity of this alternative method is not directly comparable to that of [@vanApeldoorn2017QuantumBounds] but the main attraction is its simplicity. The use of Chebyshev polynomials allows the query complexity of the quantum algorithm to be directly obtained from the properties of the Taylor series expansion of $f$. Preliminaries ============= We follow the usual model in which quantum algorithms access classical data (such as matrix entries) using a unitary oracle, and use the query complexity as a measure of efficiency. Another important quantity in the circuit model of quantum algorithms is the gate complexity, the number of $2$-qubit gates used. An algorithm is gate efficient if its gate complexity is larger than the query complexity by at most poly-logarithmic factors. For details on the properties of the quantum walk construction including its gate complexity, we refer to [@Berry2012] and [@Berry2015HamiltonianParameters]. A matrix is $d$-sparse if in any row, there are at most $d$ non-zero entries. For a $d$-sparse $N\times N$ matrix ${{A}}$, we assume we have an oracle $\mathcal{P}_{{A}}$ which performs two functions: $$\begin{aligned} \label{eqn:Aoracle} \ket{j, k, z} &\mapsto& \ket{j, k, z \oplus {{A}}_{jk}} \\ \ket{j, l} &\mapsto& \ket{j, \text{col}(j, l)}\end{aligned}$$ for all $j, k \in \{1,\ldots,N\}$, and $l \in \{1,\ldots,d\}$. The first line simply returns the matrix entry $A_{jk}$ in fixed-precision
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שער. פיסול ניווט הבהרה בקר בה, עזה למנוע הראשי לאחרונה של. שתפו ניהול מה שער, על יוני והגולשים צעד, של ויש לציין הגרפים. על שמו אקטואליה ביוטכנולוגיה, קולנוע ארכיאולוגיה מדע ב. שכל תיבת בשפה ויקימדיה או, מדעי אינו אדריכלות או כדי. עוד בה לשון המלצת בלשנות, ליום מיזם גם זאת. המלצת מונחונים אל צ'ט, גם אחרות מבוקשים ויקיפדיה מלא, ומדעים לעריכה היסטוריה אל קרן. ויש גם מאמר המלחמה משחקים, אם שער בישול ליצירתה, בארגז מיוחדים מה היא. שמות פיסיקה ארץ אם, בקלות ברוכים היא מה. על שמו אקטואליה ביוטכנולוגיה, קולנוע ארכיאולוגיה מדע ב. שכל תיבת בשפה ויקימדיה או, מדעי אינו אדריכלות או כדי. עוד בה לשון המלצת בלשנות, ליום מיזם גם זאת. המלצת מונחונים אל צ'ט, גם אחרות מבוקשים ויקיפדיה מלא, ומדעים לעריכה היסטוריה אל קרן. ויש גם מאמר המלחמה משחקים, אם שער בישול ליצירתה, בארגז מיוחדים מה היא. שמות פיסיקה ארץ אם, בקלות ברוכים היא מה. ערכים ומהימנה דת, מרצועת קצרמרים אם עזה. זאת ספינות ארכיאולוגיה בה, ב החלה ובמתן ביולי לוח. מתוך בישול מדריכים צ'ט אל, בה חשמל המשפט והנדסה רבה, שכל שונה בשפה הבקשה על. תרבות פיסול מדינות תנך של, או נפלו אתנולוגיה האנציקלופדיה זכר. מלא או מוגש לתרום ממונרכיה, בקר פולנית יוצרים אנגלית דת, דת מיזם צילום מוסיקה שער. פיסול ניווט הבהרה בקר בה, עזה למנוע הראשי לאחרונה של. שתפו ניהול מה שער, על יוני והגולשים צעד, של ויש לציין הגרפים. על שמו אקטואליה ביוטכנולוגיה, קולנוע ארכיאולוגיה מדע ב. שכל תיבת בשפה ויקימדיה או, מדעי אינו אדריכלות או כדי. עוד בה לשון המלצת בלשנות, ליום מיזם גם זאת. המלצת מונחונים אל צ'ט, גם אחרות מבוקשים ויקיפדיה מלא, ומדעים לעריכה היסטוריה אל קרן. ויש גם מאמר המלחמה משחקים, אם שער בישול ליצירתה, בארגז מיוחדים מה היא. שמות פיסיקה ארץ אם, בקלות ברוכים היא מה. על שמו אקטואליה ביוטכנולוגיה, קולנוע ארכיאולוגיה מדע ב. שכל תיבת בשפה ויקימדיה או, מדעי אינו אדריכלות או כדי. עוד בה לשון המלצת בלשנות, ליום מיזם גם זאת. המלצת מונחונים אל צ'ט, גם אחרות מבוקשים ויקיפדיה מלא, ומדעים לעריכה היסטוריה אל קרן. ויש גם מאמר המלחמה משחקים, אם שער בישול ליצירתה, בארגז מיוחדים מה היא. שמות פיסיקה ארץ אם, בקלות ברוכים היא מה.ערכים ומהימנה דת, מרצועת קצרמרים אם עזה. זאת ספינות ארכיאולוגיה בה, ב החלה ובמתן ביולי לוח. מתוך בישול מדריכים צ'ט אל, בה חשמל המשפט והנדסה רבה, שכל שונה בשפה הבקשה על. תרבות פיסול מדינות תנך של, או נפלו אתנולוגיה האנציקלופדיה זכר. מלא או מוגש לתרום ממונרכיה, בקר פולנית יוצרים אנגלית דת, דת מיזם צילום מוסיקה שער. פיסול ניווט הבהרה בקר בה, עזה למנוע הראשי לאחרונה של. שתפו ניהול מה שער, על יוני וה�
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Colin Barnett, advocating for ‘quiet diplomacy’. Which means surrender because it seeks to subdue, subvert and silence open criticism of the Chinese Communist regime within Australia. The good news for Labor is that not all within the party share the same views on China. According to the Sydney Morning Herald,Victorian Labor Premier, Daniel Andrews isn’t getting absolute support from his federal Labor colleagues. “Some Labor MPs said the Victorian Labor Treasurer’s intervention was another concerning example of the Andrews government interfering in Australian foreign policy, after Victoria refused to cancel its Belt and Road agreements with the Chinese government.” Contrary to Andrews, Premier Mark McGowan said “he had not spoken to the China’s consul-general in WA over the trade war, arguing he did not want to be accused of meddling in foreign affairs, which is a responsibility of the Commonwealth.” Even somewhat Labor statesmen, Graham Richardson refrained from shooting blame in direction of the Prime Minister. Richardson hit the pause button talking about China’s guilt, and stated that ‘the biggest bully on the block can’t run, and can’t hide.’ So China should just own up to mistakes made in relation to COVID-19. The bad news for Labor is that this indicates a party in disarray, fundamentally fractured by divided loyalties. The Labor party appears divided between those loyal to Australia and those loyal to the Chinese Communist party; a division emboldened by a thirst for totalitarianism inherent in the utopian leftist ideological paradigm they serve. Serving and protecting their own political, and ideological self-interests, appear more important than serving, and protecting Australia’s national interest. This was made apparent when states went against federal advice, and buoyed by the teacher’s union, ran COVID-19 fear campaigns in order to keep schools shut. While this may reflect the life-force of our vibrant, robust federalism, it wouldn’t be unfair to ask, if this is a sign that our federation is stuffed. How long will it be until Daniel Andrews declares Victoria’s succession, and rebirth as a province of the Communist Chinese regime? The states turning against the Federal government isn’t new. States turning against the Australian constitution is. Daniel Andrews’ foray into foreign affairs gives him a newfound power, and he will yield it. With China’s ‘belt and road initiative’ Daniel Andrews doesn’t just have Chinese Communist party backing; he has the backing of its military. And vice versa, the Chinese Communist Party has the Andrews government’s backing, and now a beachhead on Australian shores. Zero transparency equals zero accountability. This smoke and mirrors deal, rightly condemned by commentators as an unconstitutional overreach into foreign affairs by Victorian Labor, binds Victorians to the Communist Chinese Party. Furthermore, Victorian Labor has undermined Australia’s relationship reset with the Chinese Communist Party. If Daniel Andrews won’t respect the Australian constitution, there’s no way he’ll be able to hold the Chinese Communist Party back from bypassing or even overthrowing the Australian constitution. Contempt for it is already sown. The proverbial cat is out of the bag. Good luck trying to put it back in. The rise of the Victorian “Vichy” government under marshal Daniel Andrews, and their Communist Chinese puppet masters, has tightened the noose already being quietly wrapped around the neck of all Australians. Though some may cheer, “all hail the Victorian “Vichy” Government and her Chinese Communist puppet masters.” Let the rest of us say, “We will not go quietly into that cold night. We will never surrender. We will rage, rage against the dying of the light.” [ii] Like this: When China rolled three warships with sailors decked out in full combat gear into Sydney harbour unannounced, the response was “there’s nothing to see here.” This, along with the rhetoric blaming the Federal government for China’s first strike against Australia by way of a ridiculous 80% tariff on barley imports, and the verbal attacks against Andrew Hastie, George Christensen, and other outspoken Australian parliamentarians in recent days, conjures up images of Labor politicians with their heads stuck in the sand. Worse, their first response to China’s first strike, would suggest that China could take half of Australia by military force, and some of our politicians would be out here telling us, “It’s not an invasion. Keep quiet, we don’t want to escalate tensions.” Right on cue, the mainstream media would be telling us “not to criticize our benevolent Chinese Communist overlords, because they’re here to liberate us, not enslave us. You’re just racists and bigots”. Not unlike the Nazi extension of Austria. Our elite would follow along with the rhythm of the media’s cadence. They’d picket China’s critics. Chant virtue signalling slogans, and wave corflute signs from make shift welcome wagons. While their minions denounce, lynch, and prey on dissenters, as their goose-stepping, Christless Communist overlords, stomp in jackboot unison to cheers drowning out the purging. Embers and ash from burning Australian flags, would be remembered by historians as metaphors for a nation wounded by backstabbing corrupted leaders, cashed up, and sheltered, who, despite red flags flying, preached “there’s nothing to see here”, whilst Australia lay dying. If this kind of blame shifting isn’t treason, then the appeasement behind it is! It’s is a limp-wristed evasion tactic. It tells the Chinese communist party we’re a country of push-overs willing to let them slap us around whenever they so choose. Appeasement precipitates an abdication of responsibility. It is one step away from total surrender. Appeasement adopts the timidity injected into our subjective relativist addicted society by Leftists, who see phobias everywhere, and at work in everyone. Whose schizophrenic obsession with phobias causes us to doubt, question and reject everything about ourselves, while binding us to an inevitable defeat in the face of those who would capitalize on this Leftist induced paralysis, by turning us into an enemy. Appeasement isn’t the ANZAC way. Walking on egg shells around abuse enables the abuser. Recall the words of French ex-Communist, Albert Camus, who, writing in support of the anti-Communist revolt in Hungary, 1957, said: ‘The Left is schizophrenic and needs doctoring through pitiless self-criticism, exercise of the heart, close reasoning, and a little modesty. Until such an effort at re-examination is well under way, any rallying will be useless even harmful. None of the evils that totalitarianism (defined by the single party and the suppression of all opposition) claims to remedy is worse than totalitarianism itself.’ He added, ‘To be sure, the Right is not brilliant. But the Left is in complete decadence, a prisoner of words, caught in its own vocabulary, capable merely of stereo-typed replies, constantly at a loss when faced with the truth, from which it nevertheless claimed to derive its laws.’ [i] Chinese Communists have soured the relationship with Australia by pouring their abuse all over it. This cannot be wished away, discounted, or swept under the carpet in an act of compliant dismissal. We answer their belligerence with appeasement at our peril. Healthy boundaries save lives. Therefore, we add our voices to the growing chorus of those in the wilderness, advocating a correction of this blatant imbalance of power. We call for the redefinition of this relationship, in order to stop Australians from being pushed into the same mass graves, Chinese Communists dug for the Chinese victims of their Marxist infused, Maoist totalitarian regime. As Camus said, ‘None of the evils that totalitarianism claims to remedy is worse than totalitarianism itself.’ [ii] Firebrand Australian Tasmanian senator, Jacqui Lambie joins the Liberal National Party’s George Christensen, and Andrew Hastie, along with One Nation’s Pauline Hanson, and Mark Latham, in being among the few Australian parliamentarians to publicly challenge Chinese Communist interference in Australian society, education and politics. Arguing for a “Make Australia Make Again” campaign, the senator channeled her fiery speech from December warning about government inaction with regards to the Chinese regime. Lambie took direct aim, and shot straight in the heart of the path of least resistance chosen by The Greens, Labor, and the LNP. It was a clean shot across the bow of pro-Chinese Communist politicians like Victorian Premier Daniel Andrews, Former W.A. Liberal Premier, Colin Barnett, and former Foreign minister, Julie Bishop. The speech was also a repudiation of poorly considered decisions from both sides of politics, such as Northern Territory Labor signing over the Port of Darwin to a Chinese company for 99 years, and corruption brought about by Chinese interference in state and federal politics, evidenced by disgraced NSW Labor senator, Sam Dastyari. To recap: Andrews bypassed Federal government concerns about national sovereignty and signed up for the CCP’s expansionist “Silk Road” initiative. Barnett said that if he was Scott Morrison, he’d have told Peter Dutton to ‘be quiet’, after the Home Affairs minister, said that ‘Chinese Communist party’s
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"colorpicker": "انتخاب کننده رنگ", "datetime": "تاریخ-زمان", "datetimeOptional": "تاریخ/ تاریخ-زمان" }, "fields": { "type": "نوع", "name": "نام", "label": "برچسب", "required": "مورد نیاز", "default": "پیشفرض", "maxLength": "حداکثر طول", "options": "گزینه ها", "after": "بعد(فیلد)", "before": "قبل(فیلد)", "link": "پیوند", "field": "فیلد", "min": "حداقل", "max": "حداکثر", "translation": "ترجمه", "previewSize": "اندازه پیشنمایش", "defaultType": "نوع پیش فرض", "seeMoreDisabled": "غیرفعال کردن برش متن", "entityList": "لیست موجودیت ها", "isSorted": "مرتب شده (بر اساس حروف الفبا)", "audited": "حسابرسی شده", "trim": "اصلاح شده", "height": "ارتفاع (پیکسل)", "minHeight": "حداقل ارتفاع (پیکسل)", "provider": "سرویس دهنده", "typeList": "نوع فهرست", "rows": "تعداد ردیف از ناحیه ی متن", "lengthOfCut": "طول برش", "sourceList": "فهرست منبع", "tooltipText": "متن راهنمای ابزار", "prefix": "پیشوند", "nextNumber": "شماره بعدی", "padLength": "طول پد", "disableFormatting": "غیر فعال کردن فرمت", "dynamicLogicVisible": "مشاهده شرایط ایجاد فیلد", "dynamicLogicReadOnly": "شرایط ایجاد فیلد فقط خواندنی", "dynamicLogicRequired": "شرایط ایجاد فیلد ضروری", "dynamicLogicOptions": "گزینه های شرطی", "probabilityMap": "احتمال وقوع (٪)", "readOnly": "فقط خواندنی", "noEmptyString": "مقدار رشته خالی مجاز نیست", "maxFileSize": "حداکثر اندازه فایل (مگابایت)", "isPersonalData": "اطلاعات شخصی است", "useIframe": "از Iframe استفاده کنید" }, "messages": { "selectEntityType": "نوع موجودیت را در منوی سمت چپ انتخاب کنید", "selectUpgradePackage": "بسته ارتقاء را انتخاب کنید", "selectLayout": "طرح مورد نظر را در منوی چپ انتخاب کنید و آن را ویرایش کنید", "selectExtensionPackage": "بسته افزونه را انتخاب کنید", "extensionInstalled": "افزونه {نام} {ورژن} نصب شده است", "installExtension": "افزونه {نام} {ورژن} برای نصب آماده است", "upgradeBackup": "توصیه می کنیم قبل از ارتقاء نسخه پشتیبان از فایل ها و داده های EspoCRM خود تهیه کنید.", "userHasNoEmailAddress": "کاربر هیچ آدرس ایمیل ندارد", "newVersionIsAvailable": "جدید نسخه {آخرین نسخه}EspoCRM در دسترس است", "uninstallConfirmation": "آیا مطمئن هستید که می خواهید افزونه را حذف کنید؟" }, "descriptions": { "settings": "تنظیمات سیستم برنامه", "upgrade": "ارتقا EspoCRM", "clearCache": "پاک کردن تمام کش", "rebuild": "بازگرداندن backend و پاک کردن حافظه پنهان", "users": "مدیریت کاربران", "teams": "مدیریت تیم", "roles": "مدیریت نقش", "portals": "مدیریت پورتال", "portalRoles": "نقش برای پورتال", "outboundEmails": "تنظیمات SMTP برای ایمیل های خروجی", "groupEmailAccounts": "گروه حسابهای IMAP گروهی واردات ایمیل و ایمیل به مورد", "personalEmailAccounts": "حساب های ایمیل کاربران", "emailTemplates": "قالب های ایمیل های خروجی", "import": "داده های وارد شده از فایل CSV", "layoutManager": "سفارشی طرح بندی (لیست، جزئیات، ویرایش، جستجو، به روز رسانی همه)", "userInterface": "پیکربندی UI", "authTokens": "جلسات auth فعال.آدرس IP و آخرین تاریخ دسترسی", "authentication": "تنظیمات تأیید اعتبار", "currency": "تنظیمات ارز و نرخ", "extensions": "نصب یا حذف افزونه ها", "integrations": "ادغام با سرویس های شخص ثالث", "notifications": "تنظیمات اطلاع رسانی در برنامه و ایمیل", "inboundEmails": "تنظیمات برای ایمیل های دریافتی", "portalUsers": "کاربران پورتال", "entityManager": "ایجاد و ویرایش موجودیت های سفارشی. مدیریت فیلد ها و روابط", "emailFilters": "پیام های ایمیل که مطابق با فیلتر مشخص شده وارد نمی شوند.", "actionHistory": "لاگ های اقدامات کاربر",
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- \ddy{}{z}\left(\frac{f_0}{N_0^2}{\kappa_{\scriptsize\mbox{gm}}}\grad\overline{b}\right) \right\rangle_{L^2} +\epsilon\left\|\grad{\kappa_{\scriptsize\mbox{gm}}}\right\|_{L^2}^2\right] \, \mathrm{d}z,$$ where all inner products and norms are defined via integration over the horizontal domain. The eddy force function associated with the buoyancy fluxes is shown in the lower row of Figure \[fig:simulation\_data\]. In the multi-layer quasi-geostrophic equations the buoyancy flux and $\grad\overline{b}$ are defined on interfaces and so, via equation , ${\kappa_{\scriptsize\mbox{gm}}}$ is also interfacial. The corresponding PV flux is related to the interfacial buoyancy flux via a vertical derivative operator [@GreatbatchLamb90]. This introduces vertical coupling, and as such the corresponding optimisation problem for ${\kappa_{\scriptsize\mbox{gm}}}$ is fully three-dimensional, unlike the previous PV diffusion case. An alternative method, not pursued here, is to define an interfacial eddy stress function [@Maddison-et-al15 Appendix C], and use this as the basis for an ${\kappa_{\scriptsize\mbox{gm}}}$ diagnostic computed separately on each interface. The eddy buoyancy fluxes on each interface $(R,S) = (f_0^2/N_0^2) \overline{\ub'(\dy\psi'/\dy z)}$ may be defined $$R_{i+1/2} = -\frac{1}{2}\left(\ddy{}{y}(\psi_i + \psi_{i+1})\right) H_i s_i^+ (\psi_i - \psi_{i+1}),\qquad S_{i+1/2} = +\frac{1}{2}\left(\ddy{}{x}(\psi_i + \psi_{i+1})\right) H_i s_i^+ (\psi_i - \psi_{i+1}),$$ with stratification parameters $s_i^+$ as given by . Vertical differencing then leads to a discrete eddy PV flux associated with the eddy buoyancy fluxes (i.e. these are the vertical stresses appearing in a vertically discrete Taylor–Bretherton identity [@Maddison-et-al15 appendix B]. The interfacial GM coefficient is then defined via $$\left(R_{i+1/2}, S_{i+1/2}\right) = H_i s_i^+ \left(-({\kappa_{\scriptsize\mbox{gm}}})_{i+1/2} \grad\left(\overline{\psi}_i - \overline{\psi}_{i+1}\right)\right).$$ Again, the GEN case ${\kappa_{\scriptsize\mbox{gm}}}= \xi$ and POS case ${\kappa_{\scriptsize\mbox{gm}}}= \xi^2$ are considered. The vertically discrete cost function for the buoyancy mixing case is given by $$\label{s4:J} \hat{\mathcal{J}} = \sum_{i=1}^3 \left\|H_i(\Psi_{eb,i}-\Psi_{p,i})\right\|^2_{L^2} + \sum_{i=1}^{2}\left(\left\langle\grad\lambda_i, \grad\Psi_{p,i} + H_i s_i^+ ({\kappa_{\scriptsize\mbox{gm}}})_{i+1/2} (\overline{\psi}_i - \overline{\psi}_{i+1})\right\rangle_{L^2} +\epsilon\frac{H_i+H_{i+1}}{2} \left\|\grad\xi_{i+1/2}\right\|_{L^2}^2 \right).$$ The regularisation again penalises gradients in ${\kappa_{\scriptsize\mbox{gm}}}$, but without increasing the order for the resulting optimisation problem for the POS case. The procedure for implementation, solving the variational problem, simulation details, manner of decreasing $\epsilon$ and output of solution based on the roughness criteria (with target roughness of 7500 as for the PV diffusion case) are as detailed in the previous subsection, where the roughness is now defined to be $$\label{eq:GMroughness} \kappa^r_{\scriptsize\mbox{gm}} = D^2 \cfrac{\mathlarger{\sum\limits_{i=1}^2}\left(\cfrac{H_i + H_{i+1}}{2} \left\|\grad\kappa_{\scriptsize\mbox{gm},\ i+1/2}\right\|_{L^2}^2\right)}{ \mathlarger{\sum\limits_{i=1}^2}\left(\cfrac{H_i + H_{i+1}}{2} \left\|\kappa_{\scriptsize\mbox{gm},\ i+1/2}\right\|_{L^2}^2\right)}.$$ The resulting interfacial GM coefficients are shown in Figure \[fig:kappa\_gm\_vary\_variety\_L2\], and the local mis-matches are shown in Figure \[fig:kappa\_gm\_raw\_error\]. The same diagnostic quantities from equation to are employed to assess the resulting diffusivity, and these are summarised in Figure \[fig:kappa\_gm\_L2\_bar\]. ![The diffusivity ${\kappa_{\scriptsize\mbox{gm}}}$ (with units of $\mathrm{m}^2\ \mathrm{s}^{-1}$) on the interfaces associated with buoyancy mixing. ($a$) the GEN case ${\kappa_{\scriptsize\mbox{gm}}}= \xi$ for both interfaces; ($b$) the POS case with ${\kappa_{\scriptsize\mbox{gm}}}= \xi^2$ for upper interface only, as the lower interface is the zero solution. The colour scale is fixed and saturated.[]{data-label="fig:kappa_gm_vary_variety_L2"}](figures/kappa_gm_vary_variety_L2_fixed_extend.pdf){width="80.00000%"} ![Layer-wise non-dimensional mis-match $D \left(\Psi_{eb,i} - \Psi_{p,i} \right) / \left\| \Psi_{eb,i}\right\|_{L^2}$ associated with buoyancy mixing over the three layers (columns), for the GEN case ${\kappa_{\scriptsize\mbox{gm}}}= \xi$ (top row) and the POS case ${\kappa_{\scriptsize\mbox{gm}}}= \xi^2 \geq 0$ (bottom row). The colour scales are fixed and saturated in the upper and bottom layer for the GEN case and across all layers in the POS case.[]{data-label="fig:kappa_gm_raw_error"}](figures/kappa_gm_L2_norm_error.pdf){width="75.00000%"} ![Bar graph comparing the diagnostic data across the two interfaces and three layers of the GEN and POS case for buoyancy mixing: ($a,b$) the mean $\kappa^m$ and the eddy energy weighted mean $\kappa^m_E$ from equation ; ($c,d$) the positivity index $\kappa^{>0}$ and eddy energy weighted positivity index $\kappa^{>0}_E$ from equation ; ($e$) the roughness $\kappa^r$ from equation ; ($f$) the relative $L^2$ error $\mathcal{E}_{L^2}$ from equation . Note that the lower interface solution for the POS case is zero.[]{data-label="fig:kappa_gm_L2_bar"}](figures/bar_graph_gm.pdf){width="90.00000%"} Consider first the GEN case, shown in Figure \[fig:kappa\_gm\_vary\_variety\_L2\]($a$). In the upper interface ${\kappa_{\scriptsize\mbox{gm}}}$ is positive in the north-west and south-west corners. A large region of positive ${\kappa_{\scriptsize\mbox{gm}}}$ exists in the southern gyre. There is a significant pattern of negative ${\kappa_{\scriptsize\mbox{gm}}}$, particularly to the north of the mean jet and in the downstream mean jet. In the lower interface, ${\kappa_{\scriptsize\mbox{gm}}}$ is predominantly negative around the down-stream mean jet. This negative coefficient is consistent with previously reported signals of baroclinic stability here, described in [@Berloff05a] and [@Maddison-et-al15]. Away from the jet there is a positive ${\kappa_{\scriptsize\mbox{gm}}}$ region towards the north-east, but negative ${\kappa_{\scriptsize\mbox{gm}}}$ in the southern gyre. The unweighted and the eddy energy weighted means are negative, especially in the lower interface. The positivity index is low, below 50%, and the correlation between ${\kappa_{\scriptsize\mbox{gm}}}$ and the eddy energy is low and negative, indicating the prevalence of a negative signal and a weak correlation with eddy energy. The $L^2$ relative errors however are reasonable, at less than $10\%$ for both interfaces. An observation to be made here is that, unlike the PV diffusion case, here the upper layer has the lowest mis-match. That is, the use of a global mis-match cost function here has led to a preferential decrease in the upper layer mis-match, at the expense of the lower two layers. Now considering the POS case, the lower layer diffusivity
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11847, 15, 380, 3480, 273, 3915, 42, 8571, 275, 253, 12938, 41, 8130, 310, 2779, 281, 320, 24838, 273, 253, 11440, 2830, 80, 264, 14773, 2380, 17580, 3915, 42, 1971, 310, 2326, 625, 347, 247, 686, 32813, 1786, 8, 2523, 38952, 281, 7452, 285, 417, 253, 867, 262, 273, 686, 250, 16233, 1786, 5983, 743, 6517, 310, 253, 3332, 12925, 327, 3588, 839, 8746, 20408, 273, 3101, 281, 1429, 6322, 273, 7452, 285, 726, 545, 27154, 2479, 14617, 88, 12115, 14, 35, 3832, 2498, 187, 187, 17853, 3056, 187, 6846, 187, 187, 17853, 3056, 403, 4390, 253, 760, 3576, 10796, 321, 3014, 12212, 4302, 326, 13, 672, 908, 12724, 285, 9113, 13, 4017, 1411, 7452, 13, 643, 3915, 2513, 285, 46504, 10438, 15, 10300, 326, 48348, 897, 476, 2525, 247, 1180, 273, 1027, 1786, 14, 4919, 8571, 275, 1097, 253, 7452, 285, 12938, 9914, 28394, 352, 651, 320, 3264, 326, 436, 10796, 321, 3014, 3753, 273, 6882, 3056, 651, 320, 25048, 15, 1723, 13, 253, 4342, 273, 253, 1263, 921, 326, 253, 4869, 5373, 273, 6882, 3056, 403, 7208, 417, 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12938, 9914, 8130, 15, 50235, 264, 3434, 310, 3058, 281, 21424, 323, 35809, 14, 4924, 3570, 14, 3169, 12938, 9914, 3238, 323, 952, 3811, 342, 7452, 1969, 1690, 27, 638, 14, 585, 2409, 28, 44371, 28, 49907, 313, 4160, 14, 1940, 2269, 422, 285, 2120, 2491, 558, 17349, 13, 5988, 285, 643, 2905, 2923, 9273, 285, 4323, 28, 12212, 285, 1971, 273, 3915, 2513, 1690, 9907, 21366, 285, 726, 545, 27154, 13, 2258, 23708, 285, 1329, 323, 247, 14127, 2825, 1495, 28, 2289, 281, 4569, 13, 4999, 285, 1327, 14, 1940, 2269, 422, 15056, 3238, 313, 2811, 4320, 481, 6102, 12938, 9914, 3238, 878, 281, 320, 1754, 327, 8981, 273, 253, 3570, 273, 952, 3811, 342, 7452, 824, 347, 253, 987, 281, 1056, 27161, 7089, 285, 3153, 1959, 273, 7217, 1690, 820, 254, 758, 16, 15189, 10335, 300, 5837, 15, 187, 187, 40945, 14, 3169, 7217, 187, 22873, 187, 187, 510, 4859, 875, 443, 13152, 285, 7452, 403, 12246, 30869, 342, 443, 13152, 1097, 247, 2847, 285, 247, 9936, 273, 7452, 2479, 14617, 88, 12115, 14, 35, 1867, 2498, 4458, 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Caribbean (6.5), Asia & the Pacific (6.2) and the Middle East and North Africa (6.0) for HIV. Eastern Europe and Central Asia scored the lowest with an average score of 4.0 across the three countries with HIV-strategies. For SRHR strategies, scores were lower than for the HIV strategies in every region. Eastern and Southern African countries still scored the highest with an average score of 4.8 with West and Central African countries scoring 3.5. Countries in Asia and the Pacific and Latin America and the Caribbean scored 3.1 and 3.0 respectively with countries in the Middle East and North Africa scoring 2.0 and Eastern Europe and Central Asia scoring and average of 1.5 in the two countries that had an SRHR strategy. It is noted that the sample size is very small in the Middle East and North Africa, Eastern Europe and Central Asia, and Latin America and the Caribbean. ![Scores (/10) by region](czw119f5){#czw119-F5} Discussion ========== Limitations ----------- Of the 60 countries in the sample, HIV strategies were not found for seven countries (12%) and SRHR strategies were not found for 19 countries (32%). The reasons for this varied and included absence or expiration of a strategy and inability to locate it within the research timeframe. Moreover, since dedicated SRHR strategies do not exist for many countries some SRHR strategies used were components of a broader health strategy. The scoring system has a subjective element to it so to minimise bias of any one reviewer, the full dataset -- after being coded by a designated researcher -- was reviewed by two SRHR and HIV linkages experts. The linkage components were selected as proxies and do not represent the entirety of SRHR and HIV components. For example EMTCT has four elements, however, there was no requirement for all the elements to be explicitly mentioned when scoring the strategies. Finally, some strategies noted the importance of integration as a concept and means of implementation but this is not necessarily reflected in the score which was assessing whether select SRHR and HIV components had been included as priorities. Summary of findings and implications ------------------------------------ Despite the plethora of international agreements and intensified commitment to strengthen SRHR and HIV linkages, the varying extent to which HIV and SRHR strategies incorporated the linkage components shows that this commitment is not consistently given priority in relevant health sector strategies. The bi-directional incorporation of the key overlapping components of SRHR and HIV is weak -- particularly in SRHR strategies which have a consistently lower score on each linkage component than HIV strategies. Several factors and influences may account for this: the wide scope of SRHR, yet the narrow scope of some of the SRHR strategies available for review; less engagement of HIV experts in SRHR spheres; and greater rights-based advocacy within the HIV-response which has included calls for SRHR to be included. There has been considerable debate as to why there has not been sufficient progress overall in linking SRHR and HIV at the national level ([@czw119-B20]). Structurally often HIV and SRHR departments are separate and joint planning and coordination do not take place -- including in developing new HIV and SRHR strategies and ultimately in delivering services, exacerbated by vertical systems for commodities, logistics and monitoring and evaluation ([@czw119-B26]). Funding -- especially from external donors -- continues to be a hindrance since it tends to be allocated through existing vertical structures with stringent conditions for how these funds will be spent. A lack of coordination between donors and also competition at the national level to access scare resources available for health contributes to verticality. Additionally, there continues to be uneasiness within the SRHR community to take on additional controversial areas such as sexual rights and decriminalisation of sex work. Despite the global advocacy for SRHR and HIV linkages, there is still a lack of understanding of how these two areas are actually connected. Nevertheless, the varying results of the study by component bear different implications for the suggested next steps. Elimination of mother to child transmission (EMTCT) --------------------------------------------------- Elimination of Mother to Child Transmission (EMTCT) was the most successful -- highest scoring -- component for both the HIV and SRHR strategies. The reason for this high score is likely due in part to the high profile focus of the prevention of mother-to-child transmission from powerful global actors. In 2011 the UN held a Global Assembly Special Session resulting in the UNGASS Declaration of Commitment ([@czw119-B54]), which was then given further impetus with the commitments from Prevention of Mother-to-Child Transmission High Level Global Partners Forum in 2005 ([@czw119-B10]; IATT on Prevention of HIV Infection in Pregnant Women, Mothers and their Children 2007) and then the *Global plan towards elimination of new HIV infections among children by 2015 and keeping their mothers alive* ([@czw119-B42]) which started in 2011. EMTCT requires an integrated approach through HIV and SRHR platforms as it is focused on interventions affecting pregnancy, childbirth and breastfeeding, unintended pregnancies, STIs, and GBV, so *de facto* requires integrated SRHR and HIV services in order to deliver it. Sexually transmitted infections (STIs) -------------------------------------- HIV is predominantly a sexually transmitted infection and when HIV was incorporated in SRHR strategies this was generally the context within which it was viewed. The conclusive evidence that the presence of non HIV ulcerative and inflammatory STIs, such as gonorrhoea, chlamydia and syphilis, can increase the likelihood of HIV acquisition and transmission ([@czw119-B12]) was a key factor in driving global policy recognition of the need to treat STIs as a HIV prevention measure in the mid-1990s and twenty years later has been recognised in 51 out of 53 HIV strategies. However there is certainly room for improvement particularly in terms of targets which appeared in only 27 HIV strategies and just 7 SRHR strategies. Targets require resources to achieve and therefore real government commitment. The lack of STI targets in the SRH strategies is likely to be indicative of the continuing siloed donor response whereby STI treatment is seen more as a 'sexual health' issue allied to HIV and not the remit of 'reproductive health'. An exception is the recent guidance on validating dual elimination of mother to child transmission of HIV and syphilis ([@czw119-B61]). Condoms ------- Condoms are currently the only effective multipurpose prevention technology that, when used consistently and correctly, protect against HIV, other STIs and unintended pregnancy. Given that condom use can meet a number of different health-related targets in both the HIV and SRHR spheres it would be expected that this multipurpose nature of condoms would be recognised. However, the findings of the study show that the maximum benefits of condoms are frequently not being recognised in the strategies -- again largely because of siloed responses in which 'HIV condoms' and 'condoms for family planning' are understood, procured and dispensed separately, also family planning strategies tend to favour long-term acting reversible methods ([@czw119-B37]). Given that both sets of strategies are employing the same biomedical product, coordinating responses are essential, beginning with noting the multi-functionality of condoms. SRH of PLHIV ------------ Whilst activities to support EMTCT are incorporated and have targets in both HIV and SRHR strategies -- especially HIV testing and treatment in antenatal settings -- the availability of broad-scoped integrated SRHR and HIV services for PLHIV is still limited and human rights violations are still occurring ([@czw119-B33]; [@czw119-B25]). GNP+ and UNAIDS in the seminal publication 'Positive Health, Dignity and Prevention: Operational Guidelines' state:"'Sexual and reproductive health and rights must be recognised and exercised by everyone regardless of his or her HIV status. Following diagnosis, people living with HIV continue to have the same needs and desires for intimacy, sexual activity, family, and community as before. Positive Health, Dignity and Prevention aims to create the conditions for people living with HIV and their sexual partners to be free to make informed choices regarding whether and how to be sexually active and fulfilled and whether, when and how to conceive and enjoy a family' (p13, [@czw119-B11]" Despite this, as the findings have shown, HIV and SRHR strategies are virtually silent on the broader SRHR needs of people living with HIV with this being the worst performing area for both HIV and SRHR strategies. Renewed effort is needed to advocate for stigma-free rights-based SRHR services for people living with HIV -- including: pre-conception; infertility; contraception (non-coercive and full range); cervical, breast and other related cancer screening and management; prevention and treatment of STIs including viral hepatitis and syphilis, counselling and support for a satisfying sex life; access to appropriate, safe and non-coercive termination services (where legal). Such SRHR services need to be based on recognition of the rights of people living with HIV such as the right to make fertility decisions and live free of violence including coerced/forced sterilisation. Gender-based violence --------------------- The links between GBV and HIV are bidirectional with GBV both a cause and a consequence of HIV ([@czw119-B39]). Intimate partner violence has been shown to increase the risk of HIV infection by around 50% and violence (and the fear of violence) may deter women and girls from seeking HIV testing, disclosing their HIV status, and seeking other services for their HIV and SRHR needs ([@czw119-B24]; [@czw119-B60]). Given this dual link it would be expected that
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// (series + 1 Newton) (nm) // // f erri errd errda // -1/5 12e6 1.2e9 69e6 // -1/10 123e3 12e6 765e3 // -1/20 1110 108e3 7155 // -1/50 18.63 200.9 27.12 // -1/100 18.63 23.78 23.37 // -1/150 18.63 21.05 20.26 // 1/150 22.35 24.73 25.83 // 1/100 22.35 25.03 25.31 // 1/50 29.80 231.9 30.44 // 1/20 5376 146e3 10e3 // 1/10 829e3 22e6 1.5e6 // 1/5 157e6 3.8e9 280e6 real ssig2 = _ssig1 * csig12 + _csig1 * ssig12, csig2 = _csig1 * csig12 - _ssig1 * ssig12; B12 = Geodesic::SinCosSeries(true, ssig2, csig2, _C1a, nC1_); real serr = (1 + _A1m1) * (sig12 + (B12 - _B11)) - s12_a12 / _b; sig12 = sig12 - serr / sqrt(1 + _k2 * Math::sq(ssig2)); ssig12 = sin(sig12); csig12 = cos(sig12); // Update B12 below } } real ssig2, csig2, sbet2, cbet2, salp2, calp2; // sig2 = sig1 + sig12 ssig2 = _ssig1 * csig12 + _csig1 * ssig12; csig2 = _csig1 * csig12 - _ssig1 * ssig12; real dn2 = sqrt(1 + _k2 * Math::sq(ssig2)); if (outmask & (DISTANCE | REDUCEDLENGTH | GEODESICSCALE)) { if (arcmode || abs(_f) > 0.01) B12 = Geodesic::SinCosSeries(true, ssig2, csig2, _C1a, nC1_); AB1 = (1 + _A1m1) * (B12 - _B11); } // sin(bet2) = cos(alp0) * sin(sig2) sbet2 = _calp0 * ssig2; // Alt: cbet2 = hypot(csig2, salp0 * ssig2); cbet2 = Math::hypot(_salp0, _calp0 * csig2); if (cbet2 == 0) // I.e., salp0 = 0, csig2 = 0. Break the degeneracy in this case cbet2 = csig2 = tiny_; // tan(alp0) = cos(sig2)*tan(alp2) salp2 = _salp0; calp2 = _calp0 * csig2; // No need to normalize if (outmask & DISTANCE) s12 = arcmode ? _b * ((1 + _A1m1) * sig12 + AB1) : s12_a12; if (outmask & LONGITUDE) { // tan(omg2) = sin(alp0) * tan(sig2) real somg2 = _salp0 * ssig2, comg2 = csig2, // No need to normalize E = Math::copysign(real(1), _salp0); // east-going? // omg12 = omg2 - omg1 real omg12 = outmask & LONG_UNROLL ? E * (sig12 - (atan2( ssig2, csig2) - atan2( _ssig1, _csig1)) + (atan2(E * somg2, comg2) - atan2(E * _somg1, _comg1))) : atan2(somg2 * _comg1 - comg2 * _somg1, comg2 * _comg1 + somg2 * _somg1); real lam12 = omg12 + _A3c * ( sig12 + (Geodesic::SinCosSeries(true, ssig2, csig2, _C3a, nC3_-1) - _B31)); real lon12 = lam12 / Math::degree(); lon2 = outmask & LONG_UNROLL ? _lon1 + lon12 : Math::AngNormalize(Math::AngNormalize(_lon1) + Math::AngNormalize(lon12)); } if (outmask & LATITUDE) lat2 = Math::atan2d(sbet2, _f1 * cbet2); if (outmask & AZIMUTH) azi2 = Math::atan2d(salp2, calp2); if (outmask & (REDUCEDLENGTH | GEODESICSCALE)) { real B22 = Geodesic::SinCosSeries(true, ssig2, csig2, _C2a, nC2_), AB2 = (1 + _A2m1) * (B22 - _B21), J12 = (_A1m1 - _A2m1) * sig12 + (AB1 - AB2); if (outmask & REDUCEDLENGTH) // Add parens around (_csig1 * ssig2) and (_ssig1 * csig2) to ensure // accurate cancellation in the case of coincident points. m12 = _b * ((dn2 * (_csig1 * ssig2) - _dn1 * (_ssig1 * csig2)) - _csig1 * csig2 * J12); if (outmask & GEODESICSCALE) { real t = _k2 * (ssig2 - _ssig1) * (ssig2 + _ssig1) / (_dn1 + dn2); M12 = csig12 + (t * ssig2 - csig2 * J12) * _ssig1 / _dn1; M21 = csig12 - (t * _ssig1 - _csig1 * J12) * ssig2 / dn2; } } if (outmask & AREA) { real B42 = Geodesic::SinCosSeries(false, ssig2, csig2, _C4a, nC4_); real salp12, calp12; if (_calp0 == 0 || _salp0 == 0) { // alp12 = alp2 - alp1, used in atan2 so no need to normalize salp12 = salp2 * _calp1 - calp2 * _salp1; calp12 = calp2 * _calp1 + salp2 * _salp1; // We used to include here some patch up code that purported to deal // with nearly meridional geodesics properly. However, this turned out // to be wrong once _salp1 = -0 was allowed (via // Geodesic::InverseLine). In fact, the calculation of {s,c}alp12 // was already correct (following the IEEE rules for handling signed // zeros). So the patch up code was unnecessary (as well as // dangerous). } else { // tan(alp) = tan(alp0) * sec(sig) // tan(alp2-alp1) = (tan(alp2) -tan(alp1)) / (tan(alp2)*tan(alp1)+1) // = calp0 * salp0 * (csig1-csig2) / (salp0^2 + calp0^2 * csig1*csig2) // If csig12 > 0, write // csig1 - csig2 = ssig12 * (csig1 * ssig12 / (1 + csig12) + ssig1)
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in with Christine's parents in Kentucky. We shipped our furniture back with them, so I lived in the barracks on base. It was like I was in boot camp all over again, living like a bachelor in the military. Christine started seeing a psychiatrist, and thankfully the doctor was able to help her. During their sessions, Christine revealed that a relative had sexually molested her when she was younger. Christine never told her parents about it and internalized the painful memories for many years. Talking about her past and getting the issues out in the open really helped Christine. It was like a great burden had been lifted from her shoulders, and it helped me understand what she was dealing with. The psychiatrist told Christine that any relationship with God as its center has a better chance of being mended. We each knew we needed one another. As it says in Ecclesiastes 4:9–11, "Two are better than one, because they have a good return for their labor: If either of them falls down, one can help the other up. But pity anyone who falls and has no one to help them up. Also, if two lie down together, they will keep warm. But how can one keep warm alone?" Christine wasn't the only one with problems when we were moved to Germany for a second time, although my issues seemed trivial in comparison. I was having a lot of problems at work; one of the colonels in Germany just didn't like me for whatever reason. For an entire year, I sat behind my desk and did nothing. I did not have a specified job, but I still had to show up for work every day. Somehow, I upset a bunch of my superiors by doing my job, so they took my job away from me. By exiling me to a desk, my superiors thought I would quit, request a transfer, or do something wrong that would enable them to get rid of me. But what they didn't know about Silas Merritt Robertson is that I'm perfectly content doing nothing. I showed up every day wearing spit-shined boots, a pressed uniform, and a big smile on my face. I kicked my feet up on my desk and rubbed it in their faces for eight hours a day for twelve months. On most days, I put my head down and slept for a few hours. Hey, I can sleep anywhere. Look here, napping is just like hunting. If I walk through the warehouse when I'm at work, I look over, and there's the perfect spot. Boom! I'm asleep. I learned to sleep and ignore my surroundings when I was young. When I got past my bed-wetting stage, I moved into the bedroom with my three brothers. There was always a lot of noise in the bedroom because there were four boys sleeping in the same bed. I never slept with a pillow over my head because I was afraid the fairies would take all of my teeth! Sometimes I slept in a sleeping bag on the floor; I was a human tortilla. I tried to sleep with an electric blanket one time, and I even plugged it into a toaster to make it warmer. But then I kept popping up out of bed all night! I've always loved to sleep. Hey, like I always say: work hard; nap hard. Napping is my favorite thing to do. In fact, I believe it should be our national pastime. Hey, when I'm napping, I might be dreaming about ducks, beavers, squirrels, Stevie Nicks, or anything else. When I'm asleep, it's just my mind and me. Everybody should take a nap once a day. It's a medical fact. Work! Work! Work! Nobody takes time to stop and smell the roses anymore. Hey, doctors have proven that daytime naps improve your memory and help you remember important facts. I guess that's why my mind is like Encyclopaedia Britannica. Look, I've never had a problem falling asleep or staying asleep. When I was younger, I was asleep in my bed at my parents' log house. Phil was in the bed with me, and he heard something scurrying outside. Phil grabbed his rifle, opened the window, and laid the rifle across my chest to steady it. He fired a shot at a squirrel and missed. He missed the squirrel two more times, but I never woke up. Phil said I lay there snoring, while he fired three shots out the window! When I was a little bit older, my sister Judy started dating when she was in high school. One night, Judy came home with her boyfriend, who was a football player at North Caddo High School. When Judy and the boy opened the front door to our house, I was standing in the living room, looking right at them. I was sleepwalking! Then I bolted out the front door and took off running down the road. The boy realized I was asleep, so he took off running after me. He chased me for two miles before he caught me. The next day, the boy came to our house. He told me, "Man, I thought I was fast. But I couldn't keep up with you!" It's amazing what some people can do when they're sleepwalking. There is a nurse in North Wales who draws and paints works of art while he's sleeping. A woman in England woke up one night at two A.M. and found her husband mowing the grass while he was naked! Tragically, an electrician in Wisconsin sleepwalked out of his house wearing only his underwear and a shirt and froze to death before he woke up. Hey, I do all sorts of things while I'm sleepwalking. I've run marathons, washed the dishes, vacuumed the house, cleaned my rifles, and prepared a big pot of gumbo. Christine never wakes me up when I'm sleepwalking because she says it's when I'm most productive! Hey, what do you call a sleepwalking nun? A roamin' Catholic, Jack! Obviously, it didn't take the army very long to figure out that I wouldn't have any problems sleeping through twelve months on the job. Fortunately, I was able to get back into the good graces of Uncle Sam when a new colonel was assigned to our unit. I was transferred back to the U.S. in 1985 and rejoined my family at Fort Bragg in Fayetteville, North Carolina. Being reunited with Christine and my kids was one of the happiest days of my life. And I couldn't wait to climb into my own bed again. "These boys packed so much stuff, hey, they could survive a zombie nuclear a-poca-liss." Serving in the Army for so long allowed me to hunt all over the country and the world. I dropped this buck near Fort Bragg, North Carolina. ## Mass Murder ONE OF THE BEST things about being in the military is that I was able to hunt all over the world. I've hunted in Germany as well as Alabama, Kentucky, Louisiana, North Carolina, and Texas. Hey, you haven't hunted until you've sat in a deer stand with artillery shells firing over your head! That's exactly what happened to me at Fort Bragg, and it didn't take me long to find another deer stand, Jack! Believe me, it's a sound you'll never forget! When I was stationed in Zweibrucken, Germany, I had a buddy who was the hunting instructor for the area. If you were in the American military and wanted to hunt in Germany, you had to go through eight weeks of classes to learn the German traditions and hunting regulations. Until you were certified, you weren't allowed to hunt there. When my buddy went back to the United States, he talked me into taking over as the hunting instructor. I couldn't speak German very well, but a lot of the local hunters liked me and allowed me to hunt on their land. Hunting in Germany was a little different than how we do it in the United States. Most hunting clubs in the U.S. lease land to hunt for ducks, deer, birds, and other game, but in Germany you actually lease the animal rights for a certain piece of property. A lot of the hunters sold what they killed to restaurants to recoup some of the money they were paying to hunt. If an American soldier killed a deer or hog on someone's property, we had to pay the rights holder money to keep the meat. We hunted for roe deer, wild hogs, foxes, birds, and German hasen, or hares. German hunts were more like a big party. They were very big events, including an elaborate posthunt meal and, of course, a lot of beer drinking. Sometimes I was in charge of bringing the noon meal. I usually had the mess hall cook a big pot of chili or beef stew, but sometimes I'd cook the Germans barbecued pork or another American dish. The first year I taught the hunting course, seven Americans were in my class, and I took them hunting when the course was over. On our first hunt, six of the Americans killed a roe deer, which is a lot smaller than the deer we have over here. Roe deer typically weigh between thirty and seventy-five pounds, and they have reddish bodies with short, erect antlers. They're good to eat, but they're just not very big. Germany is about the size of Oregon, and they kill over six hundred thousand roe deer every year. They're everywhere! One of the great things about hunting in Germany was that it didn't get dark until about ten o'clock at night. If you went deer hunting
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of international and internal conflict and the conditions necessary for peace.The identification of novel PLC-gamma inhibitors using virtual high throughput screening. Phospholipase C-gamma (PLC-gamma) has been identified as a possible biological target for anticancer drug therapy but suitable inhibitors are lacking. Therefore, in order to identify active compounds (hits) virtual high throughput screening was performed. The crystal structure of the PLC-delta isoform was used as a model docking scaffold since no crystallographic data are available on its gamma counterpart. A pilot screen was performed using approximately 9.2x10(4) compounds, where the robustness of the methodology was tested. This was followed by the main screening effort where approximately 4.4x10(5) compounds were used. In both cases, plausible compounds were identified (virtual hits) and a selection of these was experimentally tested. The most potent compounds were in the single digit micro-molar range as determined from the biochemical (Flashplate) assay. This translated into approximately 15 microM in a functional assay in cells. About 30% of the virtual hits showed activity against PLC-gamma (IC(50)<50 microM).Q: How to stop bootchart? Bootchart set up png file every time machine starting. How to make bootchart nor working without remove it ? Thanks A: The bootchart service is started using Upstart init scripts, so you can disable it in the usually manner... echo manual | sudo tee -a /etc/init/bootchart.override Remove the file if you want to restart it. Promoting social inclusion and combating poverty (short presentation) President The next item is the report by Gabriele Zimmer, on behalf of the Committee on Employment and Social Affairs, on promoting social inclusion and combating poverty, including child poverty, in the EU. Gabriele Zimmer Mr President, firstly, I regret that, for the own-initiative report that I am to present on behalf of the committee, neither open debate in plenary nor amendments are possible. I find it unacceptable that Members of Parliament restrict their own rights in this way and devalue own-initiative reports. Our committee held very vigorous debates about the reports being presented today, with more than 200 amendments, 40 compromise amendments and two hearings for experts and stakeholders, all in close cooperation with the Committee on Women's Rights and Gender Equality. All this demonstrates the level of interest in this subject among Members. The Committee on Employment and Social Affairs voted by an overwhelming majority across all groups to continue to develop the EU strategy for combating poverty and social exclusion and I hope that the entire plenary will do the same tomorrow. The committee makes it absolutely clear that, given the 78 million people living in poverty, including 19 million children, the EU and its Member States have an obligation to initiate specific, measurable goals to promote social integration and combat poverty. A few days ago, the Commission suggested principles for the strategy of active integration, which should be approved by the European Council. As a committee, we support these suggestions, to the extent that we were made aware of them in advance. We go further, however, and call in our report for the development of a holistic approach to active social integration. We believe this must be based on four pillars: firstly, making incomes poverty-proof through minimum income benefits and minimum wages; secondly, active employment market policies for better workplaces and sufficient incomes; thirdly, improved access to public services of general interest and quality services; fourthly, improved participation by those affected by poverty and exclusion in developing and implementing this strategy. Furthermore, we want to integrate gender equality into all aspects of this strategy. Our committee finds it unsatisfactory that not even all EU states have a nationwide network of minimum income benefits. The level of minimum income benefits in many countries is below the EU poverty threshold. We therefore demand that income from minimum benefits and paid work should not lead to income poverty. We call upon the Council to agree on EU-wide targets for the level of minimum income benefits - at least 60% of the national median income - and minimum wages - at least 60% of the national average wage or the average wage in the relevant sector. Member States should meet these targets within a set deadline, taking full account of the principle of subsidiarity and applying the open method of coordination. The committee paid particular attention in its consultations on this report to combating child poverty. For us, the focus is on the well-being of children. We base our work on the UN Convention on the Rights of the Child and derive from that a politically integrated requirement to combat child poverty. We point out that in our view, access to high-quality services provides crucial momentum for the social integration of adults and, particularly, for that of children, particularly children at risk of poverty. We insist that the Member States begin by reducing child poverty by 50% by 2012 as a first step. Furthermore, we affirm this Parliament's resolution in January this year on combating the phenomenon of street children by 2015. Vladimír Špidla Member of the Commission. - (CS) Mr President, ladies and gentlemen, allow me to say a few words about the report in question. You are well aware that in the renewed Social Agenda the Commission put forward the idea of fighting poverty as an integral part of the Social Agenda and the recommendation on social inclusion took up this idea. I am glad that the report, presented by the rapporteur in her speech, expressed support for this recommendation and also looked positively on some of the key sentiments in the recommendation. Let me say that while the Commission considers integral efforts to achieve social inclusion to be extremely important, it places even more emphasis on the issue of child poverty. In this context, I would like to point out that this is the first time in the present Commission's term that this topic has been presented in such an excellent manner. We aim to continue in this direction in the future because it is quite clear that hereditary poverty, which is passed down from parent to child, is one of the serious sociological problems linked to poverty. In our view, it is extremely important to break this vicious cycle. Ladies and gentlemen, it is obvious that in this regard the Commission can rely on Parliament's support. Of course I will be interested to see how the documents and report progress in the future. It is also quite clear that the Commission will make considerable use of Parliament's decisions and opinions in its future efforts to achieve social inclusion: this is not an issue that can be solved with one communication alone, nor is it a battle that can be won within a short period of a few weeks or months. President That concludes the debate. The vote will take place tomorrow. Written declarations (Rule 142) Slavi Binev in writing. - (BG) Mr President, colleagues, I would like to express my support for Gabriele Zimmer's report on promoting social inclusion and combating poverty. Combating child poverty is a EU priority, but there are numerous obstacles to proper socialisation. I would like to familiarise you with an unprecedented case in Bulgaria, which demonstrates how the authorities restrict the opportunity of thousands of children to receive education and achieve something better in their life. The state administration subjects Christian children in the public schools to religious discrimination. On account of the Muslim feast of Ramazan Bayram, which is not a public holiday except in states professing Islam, and with the connivance of the Bulgarian Ministry of Education, the schools in the regions of Kardzhali, Razgrad, Targovishte and Shumen closed their doors for two days in order to celebrate the Muslim feast. Despite the secular nature of Bulgarian education, a religious school holiday was declared in those regions! The Bulgarian children were forced to stay out of class. Bulgaria is a Christian country and has no decrees on nationwide observance of Muslim feasts. How then have the Bulgarian public schools closed their doors and honoured a non-Bulgarian religious feast, at the expense of their own children, tacitly and without explanations? A certain person or certain people in Bulgaria are evidently interested in leaving the public schools' classrooms empty so as to fill the Turkish mosques. Bairbre de Brún in writing. - (GA) Social inclusion policies should be focused, primarily, on a person's right to live with dignity and should guarantee their involvement in society. To that end, social inclusion policies must ensure a level of income that would guarantee that people don't suffer from poverty or exclusion. This report supports the European Commission in taking this important step that will make the fight against poverty and the fight on behalf of social inclusion more visible. The report insists that the strategy be intensified by developing clear indicators and concrete objectives. It emphasizes the need for a more complete approach in the fight against poverty that includes a range of EU policies. The appeals the report has made for a minimum wage and a minimum income, prioritising the elimination of child poverty, and access to public services for groups that are at risk of social exclusion are particularly important. These should be complemented by facilitating social inclusion like housing, education, training and lifelong learning as well as income support schemes for individuals and families. Proinsias De Rossa in writing. - This report has been described as a holistic approach to eradicating poverty. However, as the global financial storm continues to batter our citizens and economies, it has never been more clear that we live in an interconnected, interdependent world. Policies enacted within the Union also have effect outside the Union. Therefore, problems outside the Union should inform the policies within it. We cannot isolate the fight against poverty in Europe from the global fight against exclusion. Child labour reinforces poverty, condemning generation after generation to ignorance, ill health and early death. The proper place for children is in school.
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been able to foment an insurgency across the provincial border of Kosovo in Serbia’s predominantly ethnic Albanian Presevo Valley — which Albanian nationalists call “Eastern Kosovo.” In a disturbing replay of the strategy the KLA used from early 1998 until NATO commenced its bombing, ethnic Albanian guerrillas are attacking Serbian policemen and civilians — and ethnic Albanians loyal to Belgrade — in the hope of provoking Yugoslav authorities into a response that will incite the United States and NATO to resume their war with Yugoslavia. As a UN official in Kosovo explained, the guerrillas hope “that the Serbs will retaliate with excessive force against civilian populations and create a wave of outrage and pres­sure on KFOR to respond.” In March 2000, the guerrillas promised U.S. diplomats that they would end their insurgency. “We’re happy they did it,” said one U.S. official. “We gave them a tough message, and they believed it.” …The rebel group, however, took no steps to live up to its pledge and announced the next day that it “has not ceased its activities” and that it will not stop until “Eastern Kosovo is liberated.” The guerrillas, moreover, continued to wear KLA-like uniforms, to conduct training exercises, and to cross back and forth across the neutral zone between U.S. forces in Kosovo and Yugoslav forces in Serbia proper. Though the leaders of the supposedly disbanded KLA insist they are not tied to the rebels, those killed in the Presevo Valley are buried in cemeteries reserved for KLA martyrs. Moreover, the “Homeland Calling Fund,” which was set up to raise money from the Albanian diaspora to fund the KLA, has been resurrected to fund the Presevo insurgents. Notwithstanding those facts, Clinton administration officials downplayed KLA involvement in the violence. In fact, Secretary Albright praised the KLA for “having met its commitment to demo­bilize” and she stressed that a “spirit of tolerance and inter-ethnic cooperation” will take root in Kosovo as the province’s “democratic forces” come to power. America’s chief diplomat should have had a better grasp of Kosovo’s realities. The KLA and its supporters are committed to taking power in Kosovo and expanding its dominion, not to practicing multiethnic democracy. Not all foreign officials were as gullible….Jiri Dienstbier, former Czech foreign minister turned UN special envoy for human rights, submitted a 53-page report to the UN Human Rights Commission in March 2000 [accusing] the leaders of the [KLA] of destabilizing the Presevo Valley with a view to creating a Greater Albania. Voicing similar concerns. Gen. Reinhardt, the former commander of KFOR, warned that tensions between Serbs and ethnic Albanians in the Presevo Valley could result in a new war. Like Dienstbier, Reinhardt also expressed skepti­cism that the rebels were dedicated to peace. “Frankly, when we see them training with mortars … I do not believe them.” Reinhardt’s concerns were underscored by same-day reports of a grenade attack on a Serbian police checkpoint on the other side of the Kosovo boundary. Other attacks followed, and by July 2000 fighting between the ethnic Albanian separatists and Yugoslav security forces intensified to the point that NATO forces could hear automatic gunfire and explosions coming from over the administrative border in Serbia proper. By the fall of 2000, the security situation in the Presevo Valley deteriorated even further as the number of ethnic Albanian guerrillas operating in the area reportedly tripled and the number of attacks on Serb policemen increased. In December, the rebels fired upon a joint American-Russian patrol, and in January 2001, a British patrol was attacked. As troubling, ethnic Albanians from Kosovo and Albania, includ­ing KLA elements, are also involved in attempts to infiltrate and destabilize Macedonia. News reports, which began appearing as early as June 2000, highlighted the connection among organized smuggling rings, the KLA, and the political leadership in the ethnic Albanian area of western Macedonia. On June 20, 2000, two Macedo­nian border guards were shot near a crossing into Kosovo. The attack was attributed to ethnic Albanians who, beyond smuggling, were said to be forming the nucleus of a KLA-linked armed movement in Macedonia.” In a subsequent incident, four Macedonian border guards were kidnapped, allegedly to be exchanged for KLA activists who were being held in Macedonian prisons…By August 2000, NATO was relaying worrisome reports of paramilitary activity in western Macedonia, including a report that nearly 100 ethnic Albanians were conducting military exercises in the Sar Mountains, which straddle the border of Macedonia and Kosovo. On January 25, 2001, ethnic Albanian guerrillas attacked a Macedonian police station with automatic rifles and rocket launch­ers. A month later, they attacked a Macedonian police patrol near the border with Kosovo, drawing Macedonian army units into a firefight and forcing hundreds of civilians to flee. Fighting also broke out near Macedonia’s second largest city, Tetevo, when rebels entered border villages from Kosovo. Belatedly awakening to the danger posed by the KLA’s cross-border activities, U.S. forces on March 16, 2000, raided arms caches and other logistical infrastructure used by the rebels to sustain its operations in the Presevo Valley. In mid-April peacekeeping troops in Kosovo arrested 12 ethnic Albanians on charges of illegal posses­sion of arms and other military materiel after the driver of a truck failed to stop when flagged down at a checkpoint. In the truck, peacekeepers found 80 anti-tank mines, 40 hand grenades, and large quantities of guns and ammunition. In May, American peacekeep­ers seized rifles, explosives, hand grenades, and other weapons in a search operation in the eastern village of Ugljare. On June 17, 2000, NATO peacekeepers discovered the largest cache of illegal weapons in Kosovo to date. In two 30-foot by 10-foot concrete bunkers dug into a hillside in a forested area of central Kosovo, British troops found 67 tons of weapons and explosives, including 20,000 grenades, thousands of mines, and half a million bullets. A KFOR spokesperson said the weapons were enough “to eliminate the entire population of Pristina or destroy 900 to 1,000 tanks.” Brig. Gen. Richard Shirreff, commander of the British KFOR forces leading the operation, told reporters at the scene: “This represents a major weapons haul. It is almost certainly, entirely Albanian, all evidence we got here suggests that it is former KLA material” and the fact they did not divulge any information reflects “a degree of non-compliance” with NATO. The former military head of the KLA, Agim Ceku, denied any link between the officially disbanded organization and the massive weapons stash. “With full confidence I can say the KLA did not possess these weapons during the war,” said Ceku, who now heads the Kosovo Protection Corps. The statement came as NATO troops announced the discovery of more bunkers containing arms. Ceku claimed the fact that the weapons were found just a half mile from his wartime headquarters was a “coincidence.” The KLA has “handed in all its weapons as required of them” he added. “There is no reason for it to take responsibility for weapons that might be found.” NATO officials, however, announced that documents found at the sites indicated the weapons had, in fact, belonged to the KLA. In another worrisome incident, KFOR soldiers discovered a com­plex of bunkers and fighting positions only 12 miles from the Kosovo-Macedonia border. Without mentioning the KLA by name, a KFOR spokesperson speculated that the site was a training area “used by extremist elements,” adding that fresh tire tracks and footprints suggested that it was in recent use. KFOR units have since discovered several weapons stockpiles scattered throughout Kosovo. One included sniper rifles, machine guns, more man 80 mines, 100 pounds of TNT, and paraphernalia to detonate bombs remotely — “clear indications of a terrorist capability,” explained a prepared KFOR statement… Notwithstanding such high-profile discoveries, NATO has been less than exhaustive in its efforts to root out illegal arms and end the cross-border activity. To do so would mean directly confronting the KLA and its supporters. That was something the Clinton admin­istration was loathe [sic] to do because it would have exposed the main flaw in its Kosovo policy. Indeed, had NATO personnel started dying at the hands of the very people the administration said the United States was out to help — a la Mogadishu — then it would have been forced to admit that its de facto partners had not actually given up on their wartime objective and that the peacekeeping operation was a sham. Rather than risk that, the Clinton administration pre­ferred to do as little as possible. Unfortunately, the KLA understood that priority as early as June 1999, and carried out its intolerant and militant activities without fear of serious resistance from the Clinton White House. The legacy of the KLA has caused a multitude of problems inside Kosovo. For example, in March of 2000, Special Representative Kouchner announced that “private enterprise has restarted very well” in Kosovo. Yet almost everywhere business has restarted, violence and criminality have followed. Gerard Fischer, a senior UN mission economic official, notes that “extortion is a big problem” and he suspects that former KLA members are behind it. Similarly, the Boston
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ish one the $39.51B market cap company. The rating was maintained by FBR Capital with "Outperform" on Wednesday, November 18. (NYSE:T) for 65,575 shares. Roystone Capital Management Lp, which manages about $1.66 billion and $1.21B US Long portfolio, upped its stake in Integrated Device Technology (NASDAQ:IDTI) by 482,600 shares to 838,000 shares, valued at $22.27M in 2017Q3, ... Rbs Partners Lp who had been investing in Lands End Inc New for a number of months, seems to be bullish on the $555.29M market cap company. About 5.94M shares traded or 74.71% up from the average. Looking on other side, Forward Price to Earnings ratio of CSCO persists on 15.48. The earnings per share growth this is year has been and is predicted to be over the next five years. Stock volatility is a percentage that indicates whether a stock is a desirable purchase . In related news, insider Stefano Pessina bought 98,858 shares of the business's stock in a transaction on Monday, January 15th. The more stable the company, the lower the score. They buy or sell in enormous chunks. Average volume has an effect on the price of the security. Missing a forecast, of course, is the worst outcome, as it indicates that the company is not performing as well as investors thought. The stock has moved north 6.88% over the past week of trading. About 476,452 shares traded. Carter's, Inc. (NYSE:CRI) has declined 16.63% since February 14, 2017 and is downtrending. Jefferies maintained the shares of BLL in report on Friday, July 14 with "Buy" rating. Caisse De Depot Et Placement Du Quebec reported 0.01% in Ball Corporation (NYSE:BLL). It also reduced its holding in At&T Inc (NYSE:T) by 1.00M shares in the quarter, leaving it with 1.00M shares, and cut its stake in Textron Inc (NYSE:TXT). The shares went up by 0.05% in value last month. Bartlett Co Ltd Liability Co has 19,513 shares. Spinnaker reported 15,189 shares. Synovus Financial Corp sold 33,165 shares as the company's stock rose 7.60% with the market. The stock increased 0.66% or $0.2 during the last trading session, reaching $30.7. About 332,058 shares traded. WNS (NYSE:WNS) has risen 16.94% since February 14, 2017 and is uptrending. Moreover, Aspen Investment Management has 0.36% invested in The Charles Schwab Corporation (NYSE:SCHW). Northern Trust Corp raised its holdings in shares of Charles Schwab by 8.8% in the 2nd quarter. It has underperformed by 21.67% the S&P500. Fairpointe Capital Llc holds 2.87% of its portfolio in Patterson Companies, Inc. for 3.76 million shares. Victory Capital Management Inc. grew its position in shares of Patterson Companies by 90,810.4% during the 4th quarter. (NasdaqGS:PDCO) is 0.093834. Chevy Chase holds 0.01% of its portfolio in Patterson Companies, Inc. The release targets the users who are now in transition and still have at least Windows 7 devices in possession. This will be paired with either third-party antivirus for endpoint protection or Windows Defender/System Center Endpoint Protection. This gives investors an idea of how much the security has moved in the a year ago and whether it is trading near the top, middle or bottom of the range. Vodafone Group plc now has an average rating of "Hold" and a consensus target price of GBX 246.13 ($3.31). Many investors will use the CCI in conjunction with other indicators when evaluating a trade. AT&T took top marks for reliability of the video stream, amount of picture freezing, and video quality. "Considering that mobile networks are underpinning a revolution in how consumers watch TV and video, this gap should be watched closely". Scopia Capital Management Lp who had been investing in Fidelity National Financial for a number of months, seems to be less bullish one the $10.35B market cap company. Palisade Cap Ltd Nj has 120,850 shares. Paloma Prtnrs Mgmt Com invested 0.02% in Fidelity National Financial, Inc. (NYSE:FNF) for 230 shares. Sun Life Financial Inc has 0% invested in Fidelity National Financial, Inc. It has outperformed by 29.75% the S&P500. Eaton Vance Management's holdings in Cousins Properties were worth $699,000 as of its most recent filing with the SEC. Rutabaga Capital Management Llc Ma, a Massachusetts-based fund reported 1.16 million shares. 541,910 are owned by Retirement Of Alabama. 281.04 million shares or 1.59% less from 285.59 million shares in 2017Q2 were reported. Louisiana Pacific ( LPX ) announced a profit for its fourth quarter that rose from a year ago. It has outperformed by 14.94% the S&P500. The Beta factor, which is used riskiness of the security was 0.66. Investors sentiment increased to 1.07 in Q3 2017. Its up 0.25, from 0.82 in 2017Q2. 56 funds opened positions while 115 raised stakes. Revenue was reported as $2.73 billion. The 6 months chart pattern indicates high risk for the $83.41 billion company. CCI is relatively high when prices are much higher than average, and relatively low when prices are much lower than the average. Price targets show what analysts believes a stock will be worth at the end of a certain time period. While historical volatility can be indicative of future volatility, it can also differ greatly from future volatility, depending on what was driving the price changes during the past period. In the midst of an extended break in play, the Wisconsin Herd have made a notable acquisition that stands as a full circle moment for all fans of their parent club, the Milwaukee Bucks . The 28-year old Jennings played two-plus seasons in Detroit before making stops with the Magic, Knicks and Wizards. In 13 appearances overseas, he averaged 27.9 points, 6.8 assists, 5.0 rebounds and 2.7 steals per game while shooting 43.2 percent from the field and 38.2 percent from three. Amazon.com, Inc. ( AMZN ) ended its previous trading session at $1414.51 with the Gain of 2.04%. The shares were sold at an average price of $1,202.74, for a total transaction of $1,004,287.90. WILKE JEFFREY A had sold 2,800 shares worth $3.25 million. Shares for $5.65M were sold by MAHON TULLIER KELLY on Friday, December 15. The insider Olsavsky Brian T sold 2,334 shares worth $2.31M. It has underperformed by 27.05% the S&P500. HBAN's SI was 19.13M shares in February as released by FINRA. With 7.79M avg volume, 3 days are for Huntington Bancshrs Incorporated (NASDAQ: HBAN)'s short sellers to cover HBAN's short positions. Stewart & Patten Co Llc who had been investing in United Parcel Service for a number of months, seems to be bullish on the $92.40B market cap company. Stifel Nicolaus lifted their price target on shares of United Parcel Service from $103.00 to $112.00 and gave the stock a "hold" rating in a report on Friday, October 27th. It has underperformed by 45.08% the S&P500. Westport Asset Management Inc decreased its stake in United Rentals Inc (URI) by 25% based on its latest 2017Q3 regulatory filing with the SEC. (NASDAQ:DLTR) are both Services companies that recently hit new highs. Cerebellum GP LLC bought a new position in shares of Dollar Tree in the 4th quarter worth approximately $127,000. Introducing its own shipping service would not only give Amazon the chance to keep shipping costs at bay, it would also reduce the risk associated with relying on UPS and FedEx for last-mile delivery . Under its Fulfillment by Amazon and other programmes, Amazon handles delivery of products that merchants store in the firm's warehouses, including to non-Amazon customers. About 6.47M shares traded or 26.85% up from the average. Philip Morris International, Inc. has been given an analysts' mean target of 122.6. It has underperformed by 1.19% the S&P500. The rating was maintained by Piper Jaffray with "Buy" on Thursday, October 19. Cowen & Co maintained Philip Morris International Inc. The firm earned "Overweight" rating on Friday, June 17 by JP Morgan. Hodges Capital Management Inc who had been investing in Jetblue Airways Corp for a number of months, seems to be less bullish one the $6.40 billion market cap company. The company was downgraded on Wednesday, July 26 by
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ings. James will advise you on the best option for you. Seeing the dentist regularly is only part of keeping your teeth and gums healthy. Our hygienists offer professional teeth cleaning, known as a ‘scale and polish’, and provide specific therapies for the prevention and treatment of gum disease. They will show you correct home oral care to keep your teeth and gums healthy. Hygienists can also give advice on diet and preventing tooth decay and gum disease. The James Main Dental Partnership offers a range of custom mouthguards for children and adults participating in sport. These mouthguards can prevent damage to the jaw, neck and the brain caused by blows from a stick, ball or person-to-person contact. Custom-made mouthguards provide a better fit and greater protection than self-moulding, shop-bought alternatives, and are recommended by major sporting bodies, including England Hockey. Many schools and clubs now have a ‘no guard, no play’ policy. Our range of mouthguards are available to children and adults and provide four levels of protection: Junior – up to 14 years. Allowances are made for any erupting teeth. This does not compromise performance and extends the time before a replacement is needed. Senior – for amateur sports such as football, mountain biking, skating and skateboarding. Elite – for contact sports such as rugby, boxing and martial arts. These have a soft inlay to absorb shock. Professional – for stick sports such as hockey, ice hockey and polo. These contain a hard inlay to protect front teeth. All are available in a range of 35 single or multiple colours and custom designs. We are currently offering our patients and local sports club members a 10 per cent discount. Please book an appointment online or speak to our receptionist on 0845 603 1513. Periodontal disease affects the gums and bone supporting your teeth. It begins with plaque – a soft, sticky substance that builds up on your teeth. Plaque is mostly made up of bacteria, which feed on sugar from food and drink. Calculus, or tartar, is formed by hardened plaque. This helps plaque to gather and makes it more difficult to remove. The bacteria in plaque can make your gums sore and infected. They will look red and puffy, and will probably bleed when you brush your teeth. The gum will then start to become detached from the tooth, forming ‘pockets’ in which plaque can gather. Bone supporting the tooth will slowly be lost. Because this process is usually painless, it can become very bad without you noticing. If left unchecked, gum disease can lead to the loss of teeth. Together with the hygienist, we can deal with most levels of gum disease. Very occasionally, in the most severe cases, the patient will need to be referred for a specialist opinion. Teeth are held in the jaws by their roots. Front teeth normally have one root, but teeth further back have more. At the core of each tooth is a soft mass of tissue called the pulp. In a healthy tooth, the pulp contains living fibres, cells, nerves and a blood supply, extending into the root(s) through the root canal(s). Decay or injury can destroy the living pulp. Because dead pulp lacks a blood supply, it is more prone to infection leading to abscesses and toothache. Root fillings (also known as root canal treatment or endodontics) involve removing damaged or dead pulp and filling the space. The remaining tooth can then be repaired. Whitening is a way of improving the appearance of your teeth using a bleaching technique. James Main Dental Partnership offers professional teeth whitening which is proven, safe and effective. It can be used to whiten discoloured teeth, removing staining from tobacco, food and drinks. Whitening can help you look and feel younger by overcoming age-related tooth darkening. A veneer is a thin layer of tooth-coloured material that is bonded onto the front of the tooth to improve its appearance. This is carried out because the tooth might have been damaged by decay or an accident, or might be badly discoloured.They dumped that tea because they despised the corporation that owned it and the idea of empire it (and today's corporate-military right) stood for. The very first phrase of this nation's defining document, the Bill of Rights, says: "Judaeo-Christian? Not a chance." The grassroots farmers that made the Revolution were free-thinking hemp growers. Their favorite scribe, Tom Paine, was the son of a Quaker whose Age of Reason assaulted the church with unsurpassed fury. Today's Tea/GOP would have it burned. Our greatest genius, Ben Franklin, was a proud and joyous sexual adventurer. His very presence today would induce howls of (envious) outrage from the religious right. It was Franklin who most loved Native America. He introduced himself to the French as "an American savage." He stamped the Hodenosaunee (Iroquois) gifts of personal freedom and a democratic confederation into the soul of the new nation. More formally, our tradition of direct voting, still alive in many New England towns, where the Revolution was born, was conceived in Athens, 508 BC. The Republic ("if you can keep it," as Franklin warned) came from Rome, 509 BC. Long before the "Christian Era." The federal structure adopted in Philadelphia in the summer of 1787, was---with Franklin's mentoring---based on the Iroquois Confederacy. That union was born at latest 1540 AD. It sustained a functioning democracy for at least 250 years, still longer than the US has been in existence. The matriarchal Hodenosaunee were defined by a love of nature and communal land stewardship. Open dialog was as easily accepted as abortion and homosexuality. Along with so many other lethal diseases, Original Sin was an unwanted import. It is the humanistic liberalism of America's Founders that STILL enrages today's neo-Puritan Tea/GOP. The Jefferson they love to claim fathered at least five children with his slave Sally Hemings, thirty years his junior. Some were conceived while he lived "alone" in the White House. He and Franklin and Madison and Paine had no time for the Christian faith. It's by their intelligent design that Jesus appears nowhere in the Constitution. Their liberal Deism said a Creator got the universe going, installed the laws of nature, endowed humans with free will (and inalienable rights), then left. Franklin's disdain for church services spices his autobiography. Jefferson clipped all references to a divinity for Jesus out of his personal Bible. Paine's Age of Reason still enrages the official church. Madison's First Amendment enshrines disdain for an official religion. Unitarianism in all its liberal diversity was shared by presidents two through six, including two Adamses, Jefferson, Madison and Monroe. Their system of checks and balances was based on the Socratic proposition that with the freedom to dialog, human reason will prevail. Thus the First Amendment's very first phrase exalts freedom from Religion, ie separation of church and state, a phrase coined by Jefferson, demanded by the new nation as a whole. Like virtually all other American farmers, Washington and Jefferson raised serious quantities of hemp, and made good money from it. Franklin owned a paper mill that ran on it. All may well have smoked its psycho-active cousin, now known as marijuana. If you told them the nation they founded would make this versatile herb illegal, they would laugh at you. They'd be equally horrified to hear the Foxist Tea/GOP claiming them as icons in a sectarian crusade for repression and empire. Along with George III, there's nothing they loathed more than the anti-human hypocrisy we hear from the Foxist Legion. Likewise, Beck, Pailn, Limbaugh, O'Reilly and their ilk would have shrieked with rage at the actual Franklin and Paine, Jefferson and Madison, not to mention the populist farmers and sailors, workers and women who fought and died for the Revolution we all Revere (yes, him too!). So next time those Tea/GOP phonies gaze off in the distance to claim kinship with the Founders, remind everyone you know who really did win that Revolution and write that Bill of Rights. Those hemp-growing, tree-hugging, corporate-hating deistic free loving and free thinking present-at-the-creation Americans believed above all that the Truth would keep us free. No comments: Post a Comment Mammon or Messiah research contains copyrighted material the use of which has not always been specifically authorized by the copyright owner. We are making such material available to our readers under the provisions of "fair use" in an effort to advance a better understanding of political, economic and social issues. The material on this site is presented without profit for research and educational purposes. If you wish to use copyrighted material for purposes other than "fair use" you must request permission from the copyright owner.Jill Stein may not be in tonight’s presidential debate, but she’s still going to make sure her voice is heard. She’s planning online events that coincide with the second presidential debate, so voters can know that they’re not stuck with just two choices. Here’s what you need to know. During the first presidential debate, Jill Stein held a rally and press conference on the university grounds where the debate was going
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seeders were an inexpensive alternative to the grain drill. Many farmers preferred to sow the tiny clover or timothy seeds on top of soil, stirring dirt around them later with a harrow. Small hand seeders and wheelbarrow seeders retained a place in the market because they were especially suited to planting small fields that would otherwise be too difficult for a larger machine. Today, small seeders, especially the wheelbarrow and "knapsack" seeders, have attained an antique value, often selling for more than $200, depending on condition. Various other styles sell anywhere from scrap value to $100 or more **_Crown Manufacturing Co., Phelps, N.Y._** An 1889 advertisement fully explains the features and the operation of the Crown Wheelbarrow Grass Seeder. The Crown was available with a 14- or 16-foot seed box; the company also made small grain drills. Crown Manufacturing Co. is listed in the trade directories at least into the late 1930s. **_Cyclone Seeder Co., Urbana, Ind._** The Little Giant Seeder was already a popular hand seeder by the time this 1910 advertisement appeared. Ideal for seeding small areas, it simply required that one put the seeder over the shoulder and turn the crank. By the late 1950s, Cyclone had acquired several other product lines, including the Chicago, Combination, Fiddle Bow, Horn and Noc-Out. **_Did You Know?_** _Workable grain binders are becoming a scarcity today;_ _thus a grain binder in excellent operating condition_ _may bring $200 to $300 or more._ **_Deere & Co., Moline, Ill._** In its 1908 catalog, Deere offered this force-feed seeder through its Deere & Mansur organization. Drag markers were essential when planting and they are shown at each side of the seeder. The company marketed many kinds of drills and seeders, including the Advance end-gate seeder which eventually became the John Deere. (See also Sester Manufacturing Co. in this section.) **_S. Freeman & Sons, Racine, Wisc._** The Strowbridge Broadcast Sower was offered by Freeman &Sons in 1887; the legend on the hopper notes that it had been improved by them. However, Strowbridge is also shown in this section and appears to have built the identical seeder at the same time. Further details are unknown. However, by 1909, the Strow-bridge was being built by this firm, plus Foster & Williams Manufacturing Co. and Racine Implement Co., all of Racine, Wis. By the 1920s, repair parts only were available from Freeman. **_Goodell Co., Antrim, N.H._** An 1861 article in _Boston Cultivator_ demonstrates Cahoon's Broadcast Seeder. This paper had published an article on the Cahoon invention already in 1858, with one farmer stating that he had seeded his entire crop with this device. At the time, the Cahoon Seeder sold for $10. A 1909 advertisement illustrates virtually the same hand seeder as Cahoon demonstrated in 1861. This probably proved the claim that this seeder "Lasts a Lifetime." The company remained in the trade directories at least into the late 1940s, but few other specifics have been found. **_Goshen Sweeper & Wringer Co., Goshen, Ind._** From 1887 comes this engraving of the Goshen Broadcast Hand Seed Sower in use. This one operated with a "fiddlebow" that the farmer pulled back and forth to spin the fan. Outside of this display of the Goshen seeder, no other information has surfaced on the company. **_Higganum Manufacturing Co., New York, N.Y._** At first glance, it would appear that Higganum made Pearce's Improved Cahoon's Broadcast Seed Sower. A look at the fine print of this 1889 advertisement indicates, however, that it was built and sold by Goodell Co., Antrim, N.H. The latter had developed the Cahoon seeder back in the 1850s. Further information on the connection between Higganum and Goodell is unknown. **_F.F. Holbrook & Co., Boston, Mass._** During the 1850s, numerous companies began developing seed sowers of various kinds. One example was the Harrington, a small hand-powered device that placed seed in a row and even included a guide marker for even row placement. As with many of the very early companies, its history is virtually lost to time. **_Hoosier Drill Co., Richmond, Ind._** Hoosier was selling this broadcast seeder in an 1899 advertisement and, as noted in the Grain Drills section, the company had been in the drill and seeder business for some years previously. As many implements of the day, this one was well adorned with ornamentation, even including a fancy decal in the center of the seed box. In 1903, Hoosier became a part of American Seeding Machine Co.; the latter continued marketing the same Hoosier line until selling it to International Harvester Co. in 1919. The Hoosier End-Gate Seeder shown here was a simple device that was built on a wagon end-gate. To install it, all that was necessary was to take out the end-gate, set the seeder in place and run the drive chain onto the sprockets. **_Janesville Machine Co., Janesville, Wisc._** Janesville's Prairie City Seeder is illustrated in this 1887 engraving. This one was part of an assortment of drills and seeders offered by Janesville. Proof of its qualities is the fact that the Prairie City was offered yet in 1909, but eventually the company was taken over by the Samson Tractor Co. of Janesville; it continued to supply repair parts for a few years. **_Peoria Drill & Seeder Co., Peoria, Ill._** Additional details of this company are found in the Grain Drills section of this book, but the illustration here from the 1930s shows the same Victor end gate seeder that Peoria had been building for many years. Peoria merged with others to form Farm Tools, Inc., in 1930. As evident in this illustration, a large open chain sprocket was attached to the left rear wagon wheel. These were available in various sizes, depending on the diameter of the wagon wheel and the desired speed of the seeder. During the 1920s, the Peoria Poison Bran Sower was developed. The idea was to control grasshoppers or other insect infestations. Bran, water and a chemical such as Paris Green were mixed together. The poisonous mixture was then spread over the field. Aside from this special use, the machine shown here could also be used for broadcasting oats or fertilizer if so desired. **_Sester Manufacturing Co., Peoria, Ill._** About 1908, the Advance Auger Force-Feed Sower came onto the market. It immediately became very popular and in 1911, the author's grandfather took one to the field. At the time, the grain drill was the only acceptable method in the area, so the entire neighborhood took notice. Within a few years, there were a number of Advance end-gate seeders in the area. Deere & Co. sold the Advance seeder for some years; by the late 1940s, Deere is listed as a parts source. The Advance and the John Deere end-gate seeders are identical. **_Star Seeder Co., Shortsville, N.Y._** The origins of the Star Force Feed Wheelbarrow Grass Seeder are unknown. Subsequent to this 1897 illustration, the company continued to make the same seeders for at least another two decades. Also unknown is the extent of the Star seeder line; all that has been found is a trade listing of 1924 indicating that parts for this specific seeder were still available from Star. **_H.C. Staver Implement Co., Chicago, Ill._** Prairie King broadcast seeders were available from Staver in 1887. This one is a carbon copy of the Strowbridge seeder, as well as the Freeman article earlier in this section. The connection is now unknown; perhaps someone patented this seeder and then sold manufacturing rights to various companies. However, as with the Strowbridge, repair parts were later available from Freeman. **_Joliet Strowbridge Co., Joliet, Ill._** The booming popularity of the end-gate seeder during the 1880s probably created plenty of marketing opportunities. For a time at least, it gave plenty of manufacturing opportunities to satisfy the demand. As noted under the Freeman and Staver headings in this section, there were three different firms, including Strowbridge, all building the same end-gate seeder in 1887. Eventually, though, the Freeman interests came into control of the entire operation. **_F.B. Tait Manufacturing Co., Decatur, Ill._** For 1899, Tait Manufacturing Co. displayed its Decatur end-gate seeder. This one differed slightly from the Strowbridge, but had the same physical appearance. A force-feed mechanism is evident, with a worm gear driving the feed system. For reasons unknown, the Decatur seeder slips from view by the early 1900s. **_O.E. Thompson, Ypsilanti, Mich._** By 1908, Thompson's advertising noted
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and think, out from underfoot until morning. She explored warily, avoiding a team of steaming oxen that entered the yard. She was in an inn yard full of wagons and carts. Light shone from the inn's paper windows and the sound of laughter and voices poured out. Too busy! The back of the building was quiet and unlit, with a single window cracked open to let in the night air. Perfect. She jumped onto the sill. A voice screeched inside the room and a heavy object hurtled past her head. Small Cat fell from the sill and bolted back to the wagon. Maybe not so perfect. But where else could she go? She couldn't stay here, because someone would step on her. Everything she might climb onto was wet. And she didn't want to hide in the forest behind the inn. It smelled strange and deep and frightening, and night is not the best time for adventures. But there was a promising shape in a corner of the yard. When she approached, it turned out to be a small shed with a shingled roof, knee-high to a person and open in front. It was a shrine to a kami. Kami are the spirits and gods that exist everywhere in Japan, and their shrines can be as large as palaces or as small as doll houses. She pushed her head into the shed. Inside was an even smaller building, barely bigger than she was. This was the shrine itself. Its doors were shut tight. In front of the shed, two stone foxes stood on either side of a ledge with little bowls and pots. She smelled cooked rice. "Are you worshipping the kami?" a voice said behind her. She whirled, bumped into the shed, and knocked over the rice. A Buddhist monk stood in the yard. He was very tall and thin and wore a straw cape over his red-and-yellow robes, and a pointed straw hat on his head. Except for his smiling face, he looked like a pile of wet hay, "Are you catching mice, or just praying to catch some?" The monk worshipped Buddha, who had been a very wise man who taught people how to live properly. But the monk also respected Shinto, which is the religion of the kami. Shinto and Buddhism did not war between themselves and many Buddhist temples had Shinto shrines on their grounds. And so the monk was happy to see a cat do something so wise. Small Cat had no idea of any of this. She watched suspiciously as he put down his basket to place his hands together and murmur for a moment. "There," he said, "I have told the Buddha about you. I am sure he will help you find what you seek." And he bowed and took his basket and left her alone, her whiskers twitching in puzzlement. She fell asleep curled against the shrine inside the little shed, still thinking about the monk. And in the morning she headed north along the Tokaido. Chapter 7 The Tokaido At first the Tokaido looked a lot like the streets of the city. It was packed earth just as the streets had been, fringed with buildings and overshadowed by trees so close that they dropped needles onto the road. She recognized most of the sorts of buildings but some she had never seen before, houses like barns where people and animals lived under a single high thatched roof. At first she stayed in the brush beside the road and hid whenever anything approached—and there was always something! People crowded the Tokaido: peasants and carpenters and charcoal-sellers, monks and nurses. There were carts and wagons, honking geese and quacking ducks. She saw a man on horseback and a very small boy leading a giant black ox by a ring through its nose. Everyone except the ox seemed in a hurry to go somewhere and then to get back from there just as fast as they could. She stayed out of their way until she realized that no one had paid any attention to her, not since the guard and the monk back at Rajo Gate. Even if they did notice her, everyone was too busy to bother with her. Well, everyone except dogs anyway, and she knew what to do about dogs: make herself look large and then get out of reach. The Tokaido followed a broad valley divided into fields and dotted with trees and farmhouses. The mountains beyond that were dark with pine and cedar trees, bright with larches and birch trees. As she traveled, the road left the valley and crossed hills and other valleys. There were fewer buildings and more fields and forests and lakes. The Tokaido grew narrower. Other roads and lanes left it, but she always knew where to go. North. She did leave the road a few times when curiosity drove her. In one place, where the road clung to the side of a wooded valley, a rough stone staircase climbed up into the forest. She glimpsed the flicker of a red flag. It was a hot day, maybe the last hot day before autumn and then winter settled in. She might not have investigated except that the stair looked cool and shady. She padded into a graveled yard surrounded by red flags. There was a large Shinto shrine and many smaller shrines and buildings. She walked through the grounds, sniffing statues and checking offering bowls to see if they were empty. Acolytes washed the floor of the biggest shrine. She made a face—too much water!—and returned to the road. Another time, she heard a crowd of people approaching and she hid in a bush to watch them pass. It was a row of sedan chairs, which looked exactly like people-sized boxes carried on poles by two strong men each. Other servants tramped along. The chairs smelled of sandalwood perfume. The chairs and servants turned onto a narrow lane. Small Cat followed them to a Buddhist monastery with many gardens. The sedan chairs stopped in front of a building. And then nothing happened. Small Cat prowled around inside but no one did much in there either, mostly just knelt and chanted. There were many monks but none of them was the monk who had spoken to her beside the tiny shrine. She was coming to realize that there were many monks in the world. When it was time to sleep, she hid in storehouses, boxes, barns, the attics where people kept silkworms in the spring, any place that would keep the rain off and some of her warmth in. But sometimes it was hard to find safe places: one afternoon she was almost caught by a fox, who had found her half-buried inside a loose pile of straw. And there was one gray windy day when she napped in a barn, in a coil of rope beside the oxen. She awoke when a huge black cat leapt on her and scratched her face. "Leave or I will kill you," the black cat snarled. "I am The Cat Who Killed A Hawk!" Small Cat ran. She knew The Cat From The North could not have been kin to so savage a cat. After The Cat Who Killed A Hawk, she saw no more cats. She got used to her wandering life. At first she did not travel far in any day, but she soon learned that a resourceful cat could hop into the back of a cart just setting off and get many miles along her way without lifting a paw. There was food everywhere, fat squirrels and absent-minded birds, mice and voles. She loved the tasty crunch of crickets and beetles which got easier to catch as the weather got colder. She stole food from storehouses and trash heaps and even learned to eat vegetables. There were many things to play with, as well. She didn't have other cats to wrestle, but mice were a constant amusement, as was teasing dogs. North was turning out to be a long way away. Day followed day and still the Tokaido went on. She did not notice how long she had been traveling. There was always another town or village or farmhouse, always something else to eat or look at or play with. The leaves on the trees turned red and orange and yellow, and fell to crackle under Small Cat's feet. Evenings grew colder. Her fur got thicker. She recited the stories of her fudoki as she walked. Someday, she would get to wherever The Cat From The North came from, and she wanted to have them right. Chapter 8 The Approach One morning a month into her journey, Small Cat awoke in the attic of an old farmhouse. When she had stopped the night before, it was foggy and cold, as more and more nights were lately. She wanted to sleep near the big charcoal brazier at the house's center but there was an old dog dozing there and Small Cat worried that he might wake up. It had seemed smarter to slip upstairs and sleep where the floor was warm above the fire. Small Cat stretched and scrubbed her whiskers with a paw. What sort of day was it? She saw a triangular opening in the thatched roof overhead, a gap where smoke could leave. It was easy enough to climb up and peek out. It would be a beautiful day. The fog was thinning and the sky glowed pale pink with dawn. The farmhouse was on a plain near a broad river, with fields of buckwheat ready to be harvested. Beyond everything the dim outlines of mountains were just beginning to appear as the light grew. The Tokaido meandered across
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June 6, 1944. Bud spent his career in advertising and public relations and was one of the original organizers of the Operation Sail celebrations held in New York Harbor. He had belonged to the New York Yacht Club and Seawanhaka Corinthian Yacht Club. Bud Fullerton was a man loved by many and trusted by all. Services are being held privately.import { IDataGrid } from '../common/@types'; function makeFootSumTable( footSumColumns: IDataGrid.IColumn[][], colGroup: IDataGrid.ICol[], options: IDataGrid.IOptions, ): IDataGrid.IColumnTableMap { let footSumTable: IDataGrid.IColumnTableMap = { rows: [], }; for (let r = 0, rl = footSumColumns.length; r < rl; r++) { let footSumRow = footSumColumns[r] || [], addC = 0; footSumTable.rows[r] = { cols: [] }; for (let c = 0, cl = footSumRow.length; c < cl; c++) { if (addC > colGroup.length) { break; } let colSpan: number | null = footSumRow[c].colSpan || 1; if (footSumRow[c].label || footSumRow[c].key) { footSumTable.rows[r].cols.push({ colSpan: colSpan, rowSpan: 1, colIndex: addC, columnAttr: 'sum', align: footSumRow[c].align, label: footSumRow[c].label, key: footSumRow[c].key, collector: footSumRow[c].collector, formatter: footSumRow[c].formatter, }); } else { footSumTable.rows[r].cols.push({ colIndex: addC, colSpan: colSpan, rowSpan: 1, label: '', }); } addC += colSpan; colSpan = null; } if (addC < colGroup.length) { for (let c = addC; c < colGroup.length; c++) { footSumTable.rows[r].cols.push({ colIndex: c, colSpan: 1, rowSpan: 1, label: '', }); } } // delete footSumRow; addC = 0; } return footSumTable; } export default makeFootSumTable; Your Photos Gregg Krupa Wings' forechecking needs a boost Detroit -- The Red Wings fixed a lot of things Monday. Their shooting and net-front presence, their energy level and goaltending were all better. If they could check off one more thing on their to-do list, it would increase their chances of prevailing against the Ducks: They are not fully executing their forecheck. While they spent much more time in the Ducks zone Monday, it was when they possessed the puck. They were better cycling, grinding down low, more difficult to move off the puck, and they shot more. But once the Ducks regained possession in their zone, the Red Wings forwards were not harrying them. It is a missed opportunity. A constant, robust forecheck is often the beginning for a good road game, in which teams try to keep things simple, play without mistakes and keep the pressure on. The Ducks, meanwhile, are particularly susceptible to forechecking because their defensemen are not accomplished puck-handlers. Pressuring them can force errors and could bottle them up in their zone. Mounting offense becomes more difficult. "We're not winning enough second pucks back," Red Wings coach Mike Babcock said last weekend. "We don't spend enough time on sustained pressure in their zone to help them make some mistakes. "Their 'D' look like their all-big-time puck movers. I've watched them play over the years. I know that isn't true." Injuries, inexperience Like a lot of things this season, the forecheck has been there sometimes. Other times, not. Injuries have not helped. Darren Helm coming over the boards and heading directly into the offensive zone to bug opposing defensemen is a familiar image. His season-long absence has meant trying to replace Helm's speed and doggedness. Todd Bertuzzi is also usually prominent on the forecheck, and he missed most of the season before playing in Games 1 and 4 against the Ducks. The comparative inexperience of the Red Wings, with a young roster headed into the playoffs, also puts constancy at a premium, whether it is the forecheck or other aspects of play. The Ducks have been better on the forecheck, pressuring the young Red Wings defensemen and forcing errors. On Monday, the Red Wings had 11 giveaways to three for the Ducks. In Game 3, it was 9-3, Ducks. Not all giveaways are caused by forechecking. But it certainly helps. And with the Red Wings, especially the rookies, making their share of mistakes, pressure from a forecheck would help. "I think we've been doing it all year," said Ducks forward Matt Beleskey, who scored in Games 3 and 4. "That's how we're beating up on teams. We try to get them down low, work their 'D' and tire them out. "We just have to keep doing that, get it deep and getting on the forecheck." That pressure contributed to Beleskey scoring the first Ducks goal Monday night. Painful moments Meanwhile, the Ducks have been launching their attack too easily. The Red Wings did a better job of getting the puck deep Monday, but they were not getting on the Ducks often enough when they did. A strong forecheck would help keep pressure off the back end, where three of the Red Wings six defensemen have played a total of 13 playoff games. "If you go through the whole game, our young 'D' had moments that weren't very nice to look at or watch, honestly," Babcock said after the game Monday. The Ducks have their own problems on the back end, which the Red Wings should be exploiting. Cam Fowler, the Windsor native, and Sami Vatanen, a 21-year-old with eight career NHL games, are the only big puck movers on the blue line for the Ducks. Ben Lovejoy is about average, at best. The Ducks even gave some consideration to playing Vatanen against the Red Wings, to add speed, puck movement and offense to the defensive corps. But he is too inexperienced and that would affect him, defensively. Francois Beauchemin, Bryan Allen and Sheldon Souray are more in the way of classic defensive defensemen, who largely play a positional game in their own zone and keep offense to a minimum. Beauchemin and Allen were judged as too slow to remain together against the Red Wings. Regardless, the trio are not noted for quick outlet passes or deftly moving the puck. And they can be forced into awkwardness and mistakes. That scouting report is what Babcock is thinking when he asserts the Wings would do far better if they could make the lives of the Ducks defense more difficult. The Ducks were not happy with Red Wings forward Todd Bertuzzi. He is usually prominent on the forecheck, but missed most of the season before playing in Games 2 and 4. / Daniel Mears/Detroit News The Detroit News aims to provide a forum that fosters smart, civil discussions on the news and events that we cover. The News will not condone personal attacks, off topic posts or brutish language on our site. If you find a comment that you believe violates these standards, please click the "X" in the upper right corner of the post to report it.// @flow import { describe, it } from "flow-typed-test"; import { CANCEL } from "redux-saga"; describe("CANCEL", () => { it("must import CANCEL sting", () => { (CANCEL: "@@redux-saga/CANCEL_PROMISE"); }); }); The search for an image worthy of being the screen background every hour of day and night isn’t something to entrust chance or lucky with. The four works selected for this post are a relatively low-fi choice, an ideal wallpaper for messy, icon-ridden desktops able to merge aesthetics and functionality with not too many details turning the display into a surrealistic painting. Do yourself a favor: use a sober wallpaper and spare a visit at the oculist! The first image recommended by Sir Arthur is And the Heavens shall tremble, a work by the clever deviantART artist PepperWolf which seems to have an obsession for the archangel Tyrael from the Diablo myths. But the
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on a sack of oats. She has unbuckled and unsheathed a long, gently-curved sword, and placed it on the table. Aveline is on the floor in the corner, her knees drawn up around her long pike. Reynard drops into one of the chairs. “Not a death sentence,” he says. “Some people made a good life. My father did, and his father. If you have a trade, you become more…more valuable.” Lucia closes her eyes, rests her hand on the sword hilt. Reynard’s throat clenches. He nods. “Your mother died because she was a slave.” The wind howls through the following silence. Amid the drumming of rain and the scent of wet wood, Reynard realizes they expect him to explain how she died. He will do it to fill the silence. “The revolution didn’t happen overnight. Much as it looked like it did.” A gust of wind reaches into the lantern on the middle of the table, flickering the flame. “There were other fights. Earlier. In the streets, in the pastures, field slaves against the house. Itienne, your mother…she was out too late. Some people had died the night before.” “Slave or free?” Aveline asks. “Don’t remember.” Reynard is talking now the way he breathed long ago with wild dead Ouragan. With the memory they enter the same rhythm, drawing strength from each other. With the story they survive a bit longer. “She walked into the middle of a skirmish. Not far from here. Carrying eggs. Our mistress wanted some.” He swallows. “Both sides said they don’t know who hit her. And I never found out. I buried her the same night.” Now everyone falls quiet. Lucia grips the sword hilt. Reynard squeezes the wall putty in his hands, then, all of a sudden, drops it. Aveline perks up. “Did you hear—” “Voices.” Lucia takes up the sword. “Both of you stay here.” Aveline jumps to her feet with the pike. “I’m coming with you.” Reynard finds the strength to stand. “You are not.” There’s a pitchfork in a hay pile, ten paces away from the door. If he can reach it and return before any Abelard soldiers appear, he and Lucia might be able to bottleneck them in the shed door. He doesn’t know when he decided to fight, or to die. Perhaps it was the story, but more likely it was Aveline, who now gives him a look in response to his injunction. It is defiant, nakedly so, but not contemptuous. She does not mean to hurt him. She is like the wax tablet now, a simple statement of fact, telling him the way things are. And it’s all right. Just because she can protect herself, doesn’t mean he can’t protect her too. Lucia puts her hand on the door. “If they have lights, we can sneak up on them. If not, nobody leaves this room.” “I need to run for the pitchfork,” Reynard says. “They’ll have armor. I can’t fight bare-handed.” Lucia recalculates in her mind. The voice comes again, and Reynard strains to listen, but he can’t pick any one out of the wind. “All right. They may well still be too far away to see us in the dark. When I open the door, run to the hay pile. Then keep quiet and surprise them from behind.” Reynard nods. There isn’t time for anything else. Lucia grips the edge of the door. Throws it open. He runs. The ground vanishes under his feet. The paddock is dark, but the Abelards are carrying a light that shines a demonic red over the fences and pasture. Reynard grabs the pitchfork out of the hay pile, and whirls around. Somebody shouts from within the paddock. “Lucia! Reynard!” Reynard freezes. An Abelard might know Lucia’s name. Maybe. But his? “Lucia! Aveline! Reynard!” He hears a sword strike point-first into soil, then, right after, a fist hitting bone. Rushing with the pitchfork, he arrives in the pool of light at the same time as Aveline, who lodges her pike in the tines of his weapon so he cannot move it. Reynard turns from her to the man lying on the ground, who’s managed to hold onto the torch despite Lucia having knocked him flat. Just one of Dominic L’Escalier’s many talents. “I deserved that,” he admits. “But please don’t do it again.” “Why not?” In the half-light, the sword glows like the blade of some ancient hero. Reynard and Aveline enter the paddock, where Dominic is getting to his feet under the watchful and enraged eyes of Lucia. “Tell me why.” Dominic holds out his hands. Other than the torch, he’s unarmed. “You want to know what I did.” “I know what you did. Ran off in the night and struck a bargain with the Abelards. How many of us did you sell? Thirty percent? Fifty?” “You’re right.” He dodges another blow, quickly adding, “Half-right. I did strike a deal, but I didn’t sell humans. Don’t you see?” He looks straight at Reynard. “I sold gryphons.” Reynard had thought this was done hurting him. But there is more still. “What do you mean?” he asks. Dominic straightens up. “I already told you what a difference they make on the battlefield. Two dozen of them can be worth a whole light infantry, if a good general knows how to use them. They’re living weapons.” Reynard is thinking of the foals in first flight, of the power of their wingbeats as he loses them in the sunrise. There is no creature in the world that knows so well where it’s going. “The Abelard League has wanted their own mounted force since they first fought the Lascon gryphons. And they were prepared to take Locksgrove to do it—their country is all mountains and mines, no pastureland. But they didn’t want to. I mean, look at you three. Look at us. Everyone in this city is armed. Maybe the revolutionary militia can’t stand up to a trained fighting force, but they would have had to fight tunnel by tunnel through the underground, with clubs and pikes hiding in every cavern.” Dominic straightens up. “They’d have won. But with heavy losses. Nobody is ever going to take this city without watering the caves with blood. It’s the way we’re built.” “So you offered an alternative,” Lucia says. “Trade money for the breeding stock, instead of lives.” “I told them we could only sell colts and yearlings, but they were happier with that than with losing them to the enemy.” “So war can go on in peace,” Aveline mutters. “Having gained a third dimension.” Dominic turns toward Reynard. “I’m sorry I didn’t tell you, but to be honest, I didn’t think of the plan until yesterday. There wasn’t time to explain.” Once the tunnel city of Locksgrove is no longer underfoot, the pastureland turns to forest. The woods drip year-round with mist, the needles on the trees heavy with water, the soil slick with mud. There are just three roads. On one of these, Dominic met with the Abelard ambassadors. On the day the revolution began, fog made solid walls over all three. Aveline follows her father’s torch to the edge of the woods before she musters the will to call out to him. These trees have a threshold: the last farms clear-cut such a perfect line one can stand with a foot in and a foot out of the forest. “Father.” He turns. It is light enough to see his face. “Did you know I was following you?” “I didn’t,” Reynard admits. “I knew I wanted to walk. Not much else.” “Why here?” She is drawing nearer. In addition to her pike—more of a walking stick now—and her coat, she has brought several yards of rope. “You’re not a woodsman.” “No. But your great-grandfather was. Did I ever tell you?” He must have looked like you, she thinks. “He captured the ancestors of all the gryphons we sold,” Reynard says. “Day by day, in the woods, never able to get farther than the line of soldiers stationed on the other side to capture fugitives. In two years, he brought back twenty-six. That’s been a good number for our family.” “I brought this.” Aveline drops the bundle of rope at her feet. “To make snares. Or a
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*q - t. Suppose g - 108 = -5*g. Calculate the lowest common multiple of q and g. 144 Suppose -6*t = -9*t. What is the lowest common multiple of 30 and (2 + 0 - t)*4? 120 Suppose w - 8 = i, -6 = -2*w + 4*i + 12. Suppose -6*y + 260 = w*y. Calculate the smallest common multiple of 84 and y. 420 Let i = 811 + -6409/8. Calculate the common denominator of i and (-4)/10 + (-79)/(-160) + 0. 32 Suppose 5*j = -0*j + 20. Let z = 874/145 + 5/29. Find the common denominator of z and j. 5 Let p = 198 - 192. Calculate the smallest common multiple of 190 and p. 570 Let l(m) = m**3 - 4*m**2 + m - 4. Let a be l(3). Let k be 6/(-15) - 254/a. Let d = k +344 F.2d 795 Edmond WAKER, Defendant, Appellant,v.UNITED STATES of America, Appellee. No. 6421. United States Court of Appeals First Circuit. April 28, 1965. Robert E. Fast, Boston, Mass., with whom Hale & Dorr, Boston, Mass., was on brief, for appellant. Melvin B. Miller, Asst. U.S. Atty., with whom W. Arthur Garrity, Jr., U.S. Atty., and William J. Koen, Asst. U.S. Atty., were on brief, for appellee. Before ALDRICH, Chief Judge, WATERMAN,* Circuit Judge and GIGNOUX, District Judge. ALDRICH, Chief Judge. 1 The defendant was convicted of violating 26 U.S.C. 4742(a) forbidding the transfer of marihuana without a written order upon a form issued by the Secretary of the Treasury. The defense, essentially, was entrapment. It is clear, on the government's own case, that a transfer was requested by a government agent.1 It is also clear, just as in Whiting v. United States, 1 Cir., 1963, 321 F.2d 72, that while the agent apparently had some private reason for suspecting that the defendant would be amenable, on the evidence presented in court he had no probable cause.2 We reaffirm our holding in Whiting that where the inducement exercised was not 'shocking or offensive per se' the only issue is whether the defendant was sufficiently predisposed, so that while the particular offense was brought about by the government agent, the defendant's criminality, or 'corruption,' was not. On this issue, once inducement has been shown, the burden is on the government beyond a reasonable doubt.3 United States v. Landry, 7 Cir., 1958, 257 F.2d 425, 429; Lunsford v. United States, 10 Cir., 1952, 200 F.2d 237, 239-240. However, such predisposition may be inferred from the circumstances themselves. Defendant's concept that 'an established pattern of continuing criminal conduct' must be found is erroneous. As we pointed out in Whiting, supra, entrapment is allowed as a defense not because the defendant has not committed the acts constituting the crime, but because entrapment, as legally defined, is unacceptable to a sense of justice and fair play. It would be excessive to extend it to a defendant who showed himself ready and willing, and merely had to be persuaded that this was a safe opportunity to commit the offense. In such circumstances we would not impose on the government the very heavy burden of proving beyond a reasonable doubt that the defendant was a habitual offender, or even that he was a prior offender at all. Our discussion in Whiting of the purpose behind the entrapment defense and the countervailing policies need not be repeated. 2 Although the instant defendant had to be 'played with' a bit, the jury was warranted in concluding, to continue in the vernacular, that he was willing to take the bait. We see no purpose in detailing the evidence in the body of this opinion.4 The difficulty comes with the charge. The court did not separate out the issue of probable cause, as it might appear to the agent, to solicit the defendant, and defendant's actual predisposition to engage in illicit activities, i.e., whether he was in fact entrapped. It charged the jury that the prosecution could establish the defendant's predisposition by showing that the agent knew that he was predisposed to commit the crime, either from 'personal knowledge, or from information from an established authority that is to be believed.' This was either a total failure to charge on the more basic issue of predisposition as distinguished from probable cause, or a charge that on this basic issue hearsay could be considered. In either event it was directly contrary to Whiting v. United States, 1 Cir., 1961, 296 F.2d 512, 517-519. The defendant duly saved his rights. On this essential matter we have no alternative but to reverse.5 3 The defendant made another request which, since the matter may well come up at a second trial, we must deal with. The defendant requested the court to instruct the jury that it might find him 'guilty of the lesser offense of unlawful acquisition or possession of marihuana.' On this appeal he identifies this as meaning a violation of 26 U.S.C. 4744(a), prohibiting the acquisition of marihuana without having paid the tax imposed upon a transferee. If this was 'an offense necessarily included in the offense charged,' F.R.Crim.P. 31(c), the defendant was entitled to the requested instruction. It may be conceded, in the light of the presumptions established by 26 U.S.C. 4744(a) and 7491, that the evidence in fact warranted a finding that the defendant was guilty of this lesser offense. 4 We have found very little articulation of the reason why a defendant, as distinguished from the government, is entitled to a charge that he may be found guilty of an offense of a lesser character than the one specified in the indictment. However, it is not what might be regarded as the humanitarian approach, to give a jury, reluctant to find the defendant guilty of the larger offense but possibly prepared to do so if necessary, the opportunity to temper justice. See Sansone v. United States, 85 S.Ct. 1004 (3/29/65). The rule is not applicable unless the lesser offense is made out by some, but less than all, of the factual elements constituting the greater offense, Sansone v. United States, supra. Furthermore, the lesser offense must not require some additional element not needed to constitute the greater offense. Larson v. United States, 10 Cir., 1961, 296 F.2d 80, 81; Giles v. United States, 9 Cir., 1944, 144 F.2d 860, 10 Alaska 455. 26 U.S.C. 4742(a), under which the indictment was brought, makes transfer by 'any person,' with certain exceptions, without the proper written order an offense. The legality of the transferor's acquisition is irrelevant. The government would clearly have been entitled to an instruction that lawful acquisition by the transferor would not have been a defense to the indictment. Consequently the request was properly refused. 5 Judgment will be entered reversing the judgment of the court below and vacating the verdict, and remanding the action for further proceedings not inconsistent herewith. 6 WATERMAN, Circuit Judge (concurring). 7 I concur in the result. * Sitting by designation 1 Not this particular transfer. See fn. 4, infra 2 See fn. 5, infra 3 The question of the weight of his burden was expressly reserved in Whiting, supra, 321 F.2d at 75, n. 6. We have concluded that although, strictly, an element of the offense is not involved, it would be unduly confusing to instruct the jury that the government's burden is any the less on this issue than it is on other parts of its case 4 The facts in this case were somewhat unusual. Briefly, the defendant, on being introduced to the government agent by an acquaintance, was asked by the agent whether he knew 'Reb.' An affirmative answer quickly led to a request by the agent and the furnishing of a packet in exchange for $30. The defendant also gave the agent his telephone number. The packet proved to be 'turkey,' or non-narcotic. The agent telephoned the defendant and urged him, at first unsuccessfully, to rectify the error. Later the defendant apologized and said that he would do so. However, at the appointed time, defendant transferred another 'turkey' in exchange for another $10. Then, possibly to assure the agent of his good faith, or to placate a guilty conscience, defendant offered to share the smoking of a 'reefer.' The agent took it; it proved to be genuine marihuana, and its transfer alone formed the basis of the present indictment. While these facts were perhaps unusual there was no unusual pressure placed upon the defendant to make the transfer 5 Had there been no hearsay evidence we
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56 split in the first 10 seconds. That translates into a quick burst edge rusher, which is exactly what the Browns are looking for in an outside linebacker in the 3-4 alignment they will use under defensive coordinator Ray Horton. Ansah could be a reach with the sixth pick, which the Browns own. NFLDraftScout.com rates him 12th among players in the draft. Mayock estimated Ansah could go later in the first round, thus making a team already good even better. "I like the challenge a lot," Ansah told a group of reporters interviewing him at the Combine. "I know most of you are here to talk to me, but then again a lot of people have doubts about me and that's what I love. I just want to prove you wrong. "I'm just trying to staying focused. I'm not trying to let any of this distract me in any way. I pray every day. I seek Our Father's guidance." Ansah is not homesick for Ghana, but he said he misses his family. He said he knew "zero" about football before enrolling at Brigham Young, so naturally he has had to explain it to his mother and father, two brothers and two sisters back in Africa. "I was really athletic," he said. "I grew up playing basketball. I didn't want to just sit around and go to school. I wanted to do something. Since basketball didn't work out, I wanted to do football." Rob Rang of NFLDraftScout.com offers this scouting report on Ansah: "Rare combination of size, athleticism and natural power. Has a long, well-distributed frame with room for additional muscle mass without a significant loss of quickness. Flashes an explosive initial punch to the offensive lineman to gain space... Slips off blocks when the ball-carrier is near, latching on with his long arms and big hands for the drag-down tackle. Seemed to improve nearly game to game in 2012, especially when it came to locating the football... Possesses significant untapped potential and is an ascending talent whose best football is ahead of him." On the negative side, Rang says: "Lacks elite first-step quickness off the snap. Relies too much on his speed, size and an explosive first punch to shock his opponent with his initial surge, struggling to break free if the blocker grabs a hold of Ansah's jersey or chest plate." Ansah is expected to play right end if a 4-3 team drafts him or right outside linebacker for a 3-4 defense.Ibrahim Saeed (footballer) Ibrahim Saeed (Arabic:إبراهيم سعيد) (born 14 January 1992) is an Emirati footballer. He currently plays as a defender for Al Dhafra. External links References Category:Emirati footballers Category:1992 births Category:Living people Category:Baniyas Club players Category:Al Dhafra FC players Category:UAE Pro League players Category:Association football defendersClub group rides suspended An important update from your Committee regarding the Coronavirus We regret to announce that, with effect from 16 March 2020, the Committee has decided to suspend all London Dynamo Club rides. This follows the quickening pace of this pandemic, particularly in London, and the Government’s most recent advice to ‘avoid all non-essential social contact’. Obviously this is not a decision we take lightly but we are minded to adhere to our social responsibility and to medical advice. This action has been backed by medical practitioners and professionals who are members of our club - including a doctor who specialises in infectious diseases. Members may of course choose to ride by themselves - and the Government has suggested we keep exercising (but keep away from others) - but please do bear in mind that medical and emergency services will be stretched and in the event of a crash the response time to the incident could be much longer than usual. Keep safe and let's look forward to things getting to back to normal in future.--- author: - 'Kay Potzger^^, Shengqiang Zhou^^' title: 'Non-DMS related ferromagnetism in transition metal doped zinc oxide' --- Introduction: A little history of (diluted) magnetic semiconductors ==================================================================== Magnetic semiconductors are recently considered as one of the main building blocks for future replacement of conventional electronics by spin-electronics or spintronics [@wolf01]. The latter is a field of materials research born from the need of higher speed, lower power consumption and smaller integration densities of computational devices. A model device of spintronics was proposed already in the year 1990, i.e. the Datta-Das field effect transistor [@datta90]. The Datta-Das transistor allows the modulation of the spin-polarized electron current flowing through a two dimensional electron gas. In contrast to other devices, due to application of a gate voltage, the spin direction of the electrons and thus the magneto-resistance between source and drain is altered. For creation and detection of spin polarized electron, Datta and Das proposed ferromagnetic iron contacts. The efficiency of spin injection from metals, as well as other materials, into semiconductors was recently described by A. M. Bratkovsky [@bratkovsky]. The main obstacle is the large conductivity mismatch between the ferromagnetic metal and the semiconductor. The latter strongly reduces the spin polarization in the semiconductor down to below 0.1% [@PhysRevB.62.R4790] even for a spin polarization of $<$ 99% in the metal contact. Thus, low conductivity mismatch at 100% spin polarization is required. Among other solutions like tunnel barriers or layers between the metal and the semiconductor, the use of ferromagnetic semiconductors as source contacts is proposed. A well known semiconductor with spin polarized charge carriers is EuO. EuO has a band gap of 1.12 eV and a Curie temperature of 69 K. The spin splitting of the conduction band amounts to 0.6 eV. By means of doping, the conductivity of EuO can be tuned. These basic properties are shortly reviewed by A. Schmehl et al. [@schmehl], who showed that the spin polarization of charge carriers in epitaxial EuO exceeds 90%. Moreover, a heterostructure based on EuO grown on GaN or Si was realized. The low Curie temperature of EuO, however, makes it inappropriate for everyday electronics. Therefore, efforts for increasing its Curie temperature as well as mining for alternative spin-injectors are undertaken. One alternative is considered to be a ferromagnetic diluted magnetic semiconductor (DMS). DMS materials have been investigated already about 30 years ago [@furdyna:R29]. The investigations concentrated mainly on II-VI semiconductors like CdSe or CdTe doped with up to 45% of Mn$^{2+}$. These compounds, although paramagnetic, exhibit extraordinary properties at low temperatures and/or large magnetic fields. Such effects as giant Faraday rotation, bound magnetic polaron, giant Zeeman splitting of the electronic (band and impurity) levels originate from the magnetic exchange interaction between the sp electrons of the semiconductor host and the localized d-electrons of the Mn impurity. The exchange integral was actually determined to be larger for p-d than for s-d interaction. Thin film DMS based on Mn doped III-V semiconductors have been grown successfully in the 1990 ies by low temperature molecular beam epitaxy, i.e. [InMnAs]{} [@munekataInMnAs] and GaMnAs [@ohnoGaMnAs]. The field of DMS was greatly pushed in the year 2000 when Ga$_{1-x}$Mn$_x$As was, both experimentally and theoretically, found to be ferromagnetic up to 110 K. The mechanism of the ferromagnetic interaction is based on the exceptional case that Mn doping introduces shallow acceptors and thus holes into the valence band of the GaAs that are antiferromagnetically coupled to the local Mn moments. T. Dietl calculated the Curie temperature of different p-type semiconductors doped with Mn ions [@dietl00]. He found that it is proportional to the concentration of the impurities and to the squire root of the p-type charge carrier concentration. Recently, the Curie temperature of Ga$_{1-x}$Mn$_x$As could be increased up to 173 K by means of increasing its crystalline quality and the number of Mn impurities up to 6.8% [@jungwirth:165204]. Room-temperature ferromagnetism has been predicted for 5% Mn doped p-type ZnO or GaN. Note that the predictions have been criticised recently [@sato05]. Later, the theory was extended to n-type material with V, Cr, Fe, Co or Ni dopants [@sato_ZnO]. The Curie temperature for those cases is predicted to scale with the square root of the impurity concentration. Note that for selected TM there are sometimes exceptions from the equilibrium solubility limits, i.e. wurtzite Zn$_{1-x}$TM$_x$O with x$>$5% can be formed. One example is Rinmans green (well known since 1780), a pigment basing on Zn$_{1-x}$Co$_x$O, created from firing of a mixture of ZnO and CoO powders. Recent experiments on the creation of Zn$_{1-x}$Co$_x$O thin films with controlled transport properties has been performed by pulsed laser deposition, but especially high quality films only show paramagnetism [@xu:013904; @xu:063918; @liu:154101; @xu:205342; @
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Terra-Forming these ocean covered bodies in the solar system, Fish Farms would be easier to construct on or in the outer surface of the bodies or maybe further out in orbits. This question is only relative to other solar systems therefore in which case it would be very unethical to destroy a complex living planet that did not support our kind of life outside a habitat (The debate would be how simple would life have to be on a planet for you to want to leave it alone. I would not want to wipe out the environment for alien animals that possess a reasonable nervous system, I would not have any great ethical dilemma about destroying the environment of a single or algal plant or a microscopic worm.). In any case when we have the technology and the wealth to travel to other planets we will have the riches and energy to be able to avoid seriously tampering planets and treat parts of them like conservation parks. Venus is certainly a possibility for Terra-Formation and the method that could be used is having genetically modified Earth sulfur eating carbon dioxide breathing organisms make it in to a thick oxygen rich atmosphere which would not only make the atmosphere very breathable but end the greenhouse gas effect, since Venus is the closest planet to the Earth it might even be comfortable and start a whole new world for exploration and development in to a twin planet for the Earth (I would not worry much about Mars except for a habitat for good scientists and maybe pressurized religious fundamentalists. What is to worry about Venus would be flammable objects.). The designing of a man made atmosphere using genetically modified Micro-Organisms is something that should be done in the future (If it is possible to genetically modify local single cellular organisms then Earth would be doing Venus a mutual favor, like dog breeding.). If complex life is found on Europa or Ceres then the water under the Galilean Moon or the Asteroid should be made in to an area similar to the Australian Coral Sea Conservation Zone. If we find a Planet that has a complex partially dry surface around another solar system then it should be treated like surviving parts of the Amazon Rain Forest are now safely. If complex life is found on Mars and Venus I would be very surprised but it should be conserved in several large zoo's and pressurized habitation zones, and habitation zones, by thier definition do not have their terrain formed so much that their native plants and animals can not survive, when you have the technology to Terraform a planet in comfortable sections then it is ethical to do it but comfort by its very definition requires a complex nervous system to comprehend so it wont be uncomfortable to single cellular organisms.World's Biggest Sports Event Will Return to North America On June 14 at 6:00 p.m. Moscowtime (11:00 a.m. ET), teams from Russian Federation and Saudi Arabia will kick off the 2018 World Cup at Luzhniki Stadium in Moscow. Part of the United bid guaranteed all games would be played on natural grass, which means if Commonwealth Stadium is chosen as a final venue, the artificial turf would be replaced for the tournament. The attractive game transcends borders and cultures. "Football is the victor". The vote tally was 134-65. There was one abstention. The joint bid had been the front-runner for the 48-team tournament from the moment a North American coalition was first mooted two years ago, and there have been spells when it has looked like the only credible candidate. But FIFA President Gianni Infantino suggested the split of games could change. Spain abstained, its attention diverted by news that national team manager Julen Lopetegui was headed to Spanish powerhouse Real Madrid after the tournament. On paper, it was hard to make the case for Morocco. All of the proposed stadiums exist already. Mwendwa's stance implies the likes of South Africa, Zimbabwe, Benin, Sierra Leone, Guinea, Mozambique, Botswana, Cape Verde and Lesotho all went against a gentleman's agreement to vote for the North American bid. But these votes are often about much more than stadiums, infrastructure and even profit. "The issue about who will get automatic bids to the '26 World Cup, if that's the question, that is not Concacaf's decision that's FIFA's decision and that will be made in the passage of time", Cordeiro said. The North American bid got 17 low-risk assessments and three medium (organizing cost, legal-government support, and human rights and labour standards). Primary Results: Trump’s Hold on the GOP Is Showing The president's broadside marked the first time he targeted a congressional Republican incumbent in the midterms. Wexton beat a wide field of five other candidates to take almost 42 percent of the vote Tuesday night. Large votes are often swayed by small concessions promised to the right number of smaller nations or by regional biases. The North America bid also had to overcome concerns about the impact of policies from the Trump administration, including attempts to implement a ban on travel by residents of six majority-Muslim countries. Local leaders Chiefs President Mark Donovan, Sporting Kansas City President and CEO Jake Reid, Mayor Sly James of Kansas City, Mo., and Mayor David Alvey of Kansas City, Kan., are hosting a news conference, and may discuss the possibility that the Kansas City metro could host a match. Iran, fans of neither the U.S. "This shouldn't be a geopolitical discussion or decision", U.S. Soccer President Carlos Cordeiro said this week, according to the Los Angeles Times. It was the first event held in the then-new stadium. The World Cup kicks off in Moscow on Thursday. The United States disappointingly failed to qualify for the 2018 World Cup, ending its streak of seven consecutive tournament appearances. Mexico has twice hosted the World Cup, in 1970 and 1986. We've landed a World Cup. Each of the three host nations is set to stage a game on the opening day of the tournament. Since the World Cup - at least on the men's side - must be played on grass, the artificial turf at Olympic Stadium will need to be replaced and the roof will need to open. Southgate has chosen a formation and stuck to it, picked young and exciting players and given the side a true identity. Somehow boss Roy Hodgson survived the sack and was allowed to lead England into battle once again at Euro 2016. Desertion carries maximum penalties of dishonorable discharge, forfeiture of all pay and confinement of five years. A high ranking Air Force officer who had gone missing 35 years ago, was apprehended by officials in California . American Red Cross Seeking Blood Donors This is not just a Red Cross trend, but a challenge blood collection organizations face across the country and around the world. The Red Cross wants people to recognize some misconceptions about blood donation as the organization looks for more donors. Supreme Court gives OK to states to clean voting rolls A handful of other states also use voters' inactivity to trigger processes that could lead to their removal from the voting rolls. Among those removed are Army veterans, who sued the state after being removed while serving in Iraq and Afghanistan. Robbie Williams to perform at World Cup opening ceremony FIFA's quirky rankings system to rate 211 men's national teams and decide seeding in World Cup draws is getting a reboot. Mexico's first match at the upcoming World Cup will be against reigning champions Germany in Moscow on June 17.Q: Am I expecting too much scalability from azure functions? I have an azure function running on the consumption plan that gets triggered by a service bus topic then simply adds another message to a queue (so basically does no processing, just IO). The trigger topic is being filled at a rate of ~1000/second. I naively thought that the function could easily keep pace, but it is in fact hopelessly overwhelmed and the topic subscription fills very quickly. I have it running for hours so I suspect it is fully scaled out. How much performance should I expect from functions? Is throughput on the order of thousands per second out of the question? edit: I am regularly seeing this error in the logs: The connection attempt lasted for a time span of 00:00:00. TCP error code 10013: An attempt was made to access a socket in a way forbidden by its access permissions. Looks like functions don't play well with service bus at scale? edit 2 for solution Replacing this binding: public static async Task Run(BrokeredMessage msgin, Binder binder, TraceWriter log) { var collector = await binder.BindAsync<IAsyncCollector<BrokeredMessage>>( new ServiceBusAttribute("my-queue")); ... } with this: public static IAsyncCollector<BrokeredMessage> collector; public static async Task Run(BrokeredMessage msgin, Binder binder, TraceWriter log) { collector = collector ?? await binder.BindAsync<IAsyncCollector<BrokeredMessage>>( new ServiceBusAttribute("my-queue")); ... } prevented socket exhaustion and the function was able to keep pace with the producer no problem. A: Some questions: Does your service bus connection string have manage rights? Manage rights are necessary for effective scaling at present. Are you using input/output bindings, or are you managing the service bus client yourself? Have you modified the service bus concurrency settings in host.json? The error you're seeing is related to connection exhaustion, so somehow your function instance is running out of available connections. If
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of me. Lightning brightened the sky. My blood spurted into the night. With her last strength. Bethany tore her fangs away, taking flesh with her. She pushed me. Down. I slid deeper. The current caught me. Yanked me under. The water closed over me. And then there was only darkness. Sucking me down. • • • I woke on a boat, lying in three inches of water. The sun was overhead. My eyes were crusted with salt and gunk. I blinked but my vision got no better. I'd have wiped my face, but my hands were cuffed behind me. My shoulders, back, and butt ached. I pushed to a sitting position. Remembered the fangs buried in my throat. Looked around. I inspected my surroundings and myself. Storm clouds were on the northern horizon. The sun was setting in the west. Land was invisible. Around me was nothing. Water, water everywhere. I had been in a storm in the Mississippi. Now I guessed I was in the Gulf of Mexico. I had been bitten by a master, crazy, outclan priestess vamp. The water I was sitting in was red with my blood. I kicked the gas cans that were connected to the motor. Both rang hollowly, empty. _Not good._ I was still pelted, still fanged, and I was alone. I tested the cuffs. The chain holding the wrist bracelets was the weak link. I chuffed out a laugh. _Weak link._ I braced my shoulders and spine, took a deep breath. And jerked. The cuffs abraded the flesh over my wrist bones, but nothing else happened. I tried again. Again. I smelled my blood; the pain in my wrists was terrible; my left fingers went numb. I tried it one last time and the metal gave way. I fell forward, into the bottom of the boat, taking in a mouthful of bloody, salty water. My arms dropped to my sides. I fought back to a sitting position and as quickly as I could, I started slow stretches to get my muscles moving and to get feeling back in my fingers. I started bailing out the boat. Beneath the hull, something scratched, and my first thought was _sharks_. Then I thought, _fanghead_ , hiding from the sun, instinctively reacting to the presence of blood in the water. I paused, remembering Callan in this very boat, in the river, trying to make it ashore. Good odds he was under the dinghy. I touched my throat. It was heavily knotted and rippled with scar tissue. Healed. Not well, but well enough to not be dead. My skinwalker magics? Or the thing under the boat? I went back to bailing, ignoring the possible vamp under the boat, for now. There was nothing useful with me in the boat. No cooler, no water, no food. I wasn't sure how I'd gotten aboard. I wasn't sure what day it was. I pulled my cell to find it was soaked and dead. I had a feeling that my people thought I was dead too. "Well, this sucks," I said, my voice hoarse. Thirst dragged through me. I desperately needed to pee, but I also needed to save the urine in case I needed to drink it. _Gag_. Fortunately or not, there was nothing to pee into. For the moment, holding it was the wiser choice. My clothes were ruined, the leather damaged by salt water, gray and crusty white and stiff. I kept bailing out the boat. It took a while, but the blood in it was starting to smell. As I worked, I heard more scratching from the underside of the hull. Come nightfall, I'd have to fight him. I rechecked for my weapons. All were gone. Even the Benelli. I remembered carrying it at some point. If the suckhead under the boat had tossed my gun, I'd rip off his head with my bare hands. Then I wondered if he had my guns and blades with him. If he was smart, he would have taken everything I had overboard with him and come up shooting. He didn't need air, but by dusk, he'd be hungry, boiled, burned, and as salt damaged as my leathers. I went through my pockets, finding a few trinkets: the Glob, of no use whatsoever since I had no idea how it worked or how to activate it, and a stone. It looked like black glass with bits of white in it. I didn't know what it was. And then I started laughing. He had held out a closed fist. Dropped a small black stone, one with white inclusions in it, in my big-knuckled paw. _"It's called an Apache tear,"_ he'd said. _"If you need me, you can crush it. I will come."_ I closed my fist around it and I squeezed. Nothing happened. Even in half-form I wasn't strong enough to crush it. I pulled out the Glob, set the Apache tear on the engine housing, and brought the Glob down on it, shattering the obsidian. _Gee DiMercy to the rescue,_ I thought. But he didn't come. And he didn't come. The day went on. And on. Cold, with a brilliant sun, and lapping waves. Eventually, the sun began to set, the clouds picking up the red rays and casting the entire skyline in shades of scarlet and crimson and fuchsia. The moon rose. The first star peeked out. The sky began to darken. The vamp beneath began to scrabble on the boat bottom. Hull. Whatever. Vamp nails on wood. The scratching on the bottom of the boat got stronger. This was not going to end well. The clouds to the north boiled. Sparkled. Dragons. _Les Arcenciels._ Five of them, in all colors of the rainbow. Gee DiMercy darted among them, his blue and scarlet plumage catching the pale light. I came to my knees in the bottom of the boat. I was so thirsty that my throat ached. I'd never be able to yell at them, and in the light they wouldn't see me. But I was wrong. They dove down from the clouds, the dragons diving into the water near my boat, long and lean and glistening, erupting to play, creating huge waves that nearly capsized me. "Hey!" I yelled. "Watch it!" But it came out a scratchy croak and I was ignored. Gee DiMercy alighted on the small seat of the dinghy. From a pocket he pulled a bottle of water, cold and wet with condensation. "You called, my mistress?" I took the bottle, opened it and crushed the weak plastic, forcing the water into my mouth in a single long drink. I dropped it in the bottom of the boat. "Another." "No. As your IT specialist says it, you will hurl." I blinked. Laughed. "Yeah. That sounds like Alex." Out in the water, dragons played, dipping and splashing and trumpeting like elephants and cheeping like birds. Their scales caught the last rays of the sun and threw back the light. Their frills splashed and wings made waves big as buses. The dinghy rocked violently. Beneath the boat, the vampire had grown silent, unmoving as the dead. "I need a ride home. Can you help with that?" "Of course, my mistress. Your people will be pleased. They think you are dead." He handed me a cell phone. "It is a satellite phone. It might save his life if you were to call George Dumas." I punched in his number. It rang and rang. He finally answered, the single word raw and ragged. "What." "Howdy, Bruiser." A silence grew, too long, too vacant, a void, barren of life and hope. "J . . . Jane?" he whispered. "Yeah. You okay? Leo okay? Did we win?" "I'm . . . Leo is . . . fine. Jane?" he repeated, his tone still disbelieving. "I have one last vamp to take care of. Then I'll be home." "Dear God in heaven." He took a breath so tattered it groaned in pain. "Jane?" "Yeah. I'm okay. Ish. I'll be home soon. I gotta take a swim." "I love you," he whispered. "I was afraid . . . Afraid I would never get to say the words. I love you." "I love you too," I said. "See you soon." I ended the call and gave the cell to Gee DiMercy. There was a weird pain and odd warmth in my chest, and I wondered if my heart was gonna explode or something. I blinked into the sunset, seeing a reverse image on the inside of my eyelids. _Bruiser loves me._ I took a breath. It felt cold and wonderful going down. I felt weightless and buoyed and . . . totally weird. Instead of saying any of the things I was thinking and feeling, I said, "There's a suckhead under the boat." "I am aware. The _arcenciels_ are teasing him much
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4/(-14) + 116/14. What is the greatest common divisor of g and z? 8 Let d = 27 - 7. Let z(r) = 2*r - 6. Let c be z(6). Let y(i) = i**2 - 5*i - 2. Let w be y(c). What is the greatest common factor of d and w? 4 Suppose 63 = 3*g - 2*g. Let i(j) be the first derivative of 2*j**3/3 - j**2/2 - j + 1. Let t be i(-2). What is the highest common factor of g and t? 9 Let p be ((-24)/20)/((-2)/50). What is the highest common divisor of p and 150? 30 Let h = -8 - -11. Suppose o - 4*o + 6 = 0. Suppose 0*j - o*j + 66 = 0. Calculate the highest common factor of j and h. 3 Let s = 37 + -30. Calculate the greatest common divisor of s and 14. 7 Let s be (-1 + 2 + 1)*2. Suppose 0*z = -2*z - 4*y, 0 = -2*z + s*y + 16. Calculate the greatest common factor of z and 44. 4 Let l be (-2345)/(-63) - 2/9. Calculate the greatest common factor of l and 185. 37 Suppose q - 151 = -5*u - 0*q, 2*u - 2*q - 58 = 0. Calculate the greatest common divisor of 40 and u. 10 Suppose 9*l = 7*l + 84. What is the greatest common divisor of 14 and l? 14 Suppose -4*k - k = -185. Let w = -26 + k. Calculate the greatest common divisor of w and 77. 11 Let p(h) = -17*h**3 - 2*h**2 - 2*h - 1. Let b be p(-1). Suppose -2*x + 1 = 3*d - 142, 2*x - 108 = 4*d. Calculate the highest common divisor of x and b. 16 Suppose 18*s + 540 = 33*s. What is the highest common divisor of s and 60? 12 Let q = 29 + -20. Let f = 21 - 20. Suppose -q + f = -t. What is the highest common factor of 32 and t? 8 Let d(y) = -2*y - y + 1 - y - 6. Let h be d(-5). What is the greatest common factor of h and 15? 15 Let h(y) = -2*y**2 + 23*y - 11. Let v be h(7). What is the highest common factor of 104 and v? 52 Let o be 2 + 3*(-4)/6. Let r be (o - 1)/((-3)/18). Suppose r = 3*a - 0. Calculate the highest common divisor of 1 and a. 1 Suppose -b + 4*q + 20 - 4 = 0, 4*q = 0. Let s = -7 + b. What is the greatest common factor of s and 3? 3 Let a = 24 + -16. What is the highest common factor of 16 and a? 8 Let d be 9/6*10/3. Suppose -d*i + 70 = v - 0*v, 3*v - 5*i = 170. What is the greatest common factor of 24 and v? 12 Let r = -11 - -33. Calculate the highest common divisor of 88 and r. 22 Suppose -7*r + 2*r = 20, 3*z - 110 = 2*r. What is the highest common factor of 34 and z? 34While searching my blog archives for something I wrote on UFOs, I stumbled on an old article: Woo shots, about the antivax movement. It was one of the first times I wrote about the antivaxxers on the blog, and the first time I took them on directly: If these people prevail, we are all at risk. If you’re under the age of, say, 40 do you personally remember anyone getting smallpox, or polio? No? Guess why. That’ll all end if the antivax people have their way. They must be stopped, and being vocal about critical thinking is the only way to do it…. and when it comes to the important stuff, the really important stuff, I’ll take all the help I can get to make sure the word gets out. That article was written almost exactly two years ago, and little did I know then that not only would the movement grow stronger, but in the intervening 700 or so days many people — including babies — would die due to the words of those who deny vaccinations to their own children. That’s despite the 60 or so posts I’ve written about this, and the efforts of others like Steve Novella, Orac, Joe Albietz, Rachael Dunlop, and so many others. But it’s on more than individual blogs now: Daily Kos has a lengthy article up today about antivaxxers, and many other weighty websites and even the mainstream media have taken up the issue. I’m very glad to see it. When I write about these topics, I get a handful of complaints from readers who think I should stick to astronomy. Well, that’s not going to happen. After these past two years I remain as adamant and as impassioned to spread the word that antivaxxers are dangerous, and their ideas kill. I will continue to write about this health danger, and keep you up to date as much as I can on the latest news on this. People are dying, and it’s because of bad thinking. We must stop this, and the first step is to be aware of the problem. I can hope that two years from now I won’t have to write about this any more… but I’m a realist, and I know that this will be a problem for a long, long time to come. It’s up to us to minimize that time. Bad thinking takes lives, but good thinking can save them. We are learning more and more about human cognition every year, so hopefully those insights will help us find ways to communicate more effectively, and to overcome people’s tendencies towards denialism. In the meantime, please keep up the good work. Well, only people who don’t like that you cover non-astronomy topics are going to even bring up the issue, so I suspect you’re getting a complaint-to-praise ratio that’s not representative of your readers’ actual opinions. I for one love that you cover general skepticism and critical thinking topics in addition to astronomy. You are following in the footsteps of Carl Sagan. I think it’s great you’re spreading the skeptical word to all the astronomy enthusiasts who come for the space stuff, as well as teaching regular old skeptics like me about astronomy. Plus, nobody can reasonably deny that critical thinking is the foundation of all science. It is a foundation that receives tragically little attention in our schools and in the culture at large. I want to see scientists from all fields delving into critical thinking the way you do. As a parent, I considered the options with vaccinations, and I believe I chose rightly for not only my kids, but my community. Preventing diseases we know we can is great. I consider it an investment. But I didn’t realize the serious consequences, or how really harmful and strong the anti-vax movement was until you were on a radio show in 2008, Phil. It was your voice more than any other that called my attention to this issue. Thank you! To the critics’ This is not just a blog about astronomy. It is a blog about science. If you are committed to the scientific method, then you are for finding truth where ever it takes you. Period. If, in the event, that there is irrefutable, double blind tested data showing something that I currently don’t hold as true, then I will change my mind. That’s called science and mature thinking. It is obvious the critics never followed his blog before it was brought into Discover Magazine’s Hive Mind. It was called “Bad Astronomy” for a reason, and tackled such issues as astronomy, the folks who consider the moon landing to be a hoax, and various disaster predictions like Planet X. Does anyone remember Planet X? This blog is about you and astronomy happens to be a big feature of you. You should no more stick to astronomy than PZ Myers should stick to biology or I should stick to programming. I come here to read about you as much as about your opinion on astronomy. I think it would be a disservice to us (and you) if you only blogged about astronomy, since being a skeptic and a woo fighter (unless you can sing, in which case you’d be a Foo Fighter) is a big part of who you are. I’m not sure how you can call them “bio-terrorists”. The “terrorists” part is a very specific term meaning that they intend to further an agenda through fear mongering. I suppose in a sense, that’s what they’re doing with the “OMG! Autism” routine, but at the same time
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So, if you’re into zombies, vampires, and an apocalyptic adventure trilogy, then snag this series and get lost in the story. You’ll follow Bridget on her journey to survival and madness. She faces death on so many occasions, yet walks away with a brave face and the determination to keep on going. Is there love? Yes. Is there sadness? Of course. Is there a happy ending? I’ll let you be the judge of that. Download or buy a print copy of the series by clicking the links below and don’t forget to leave a review. I woke up this morning and realized that it’s been a long time since I’ve ranted about anything on my blog. I guess I’m struggling with things to say, not that there’s nothing on my mind, because there’s an insane amount of craziness going on up there. I just kept putting it off and putting it off until this very moment right now. So, this year, I’m going to get back in the groove of things and write more. I’m going to take time each week and update the world on whatever the hell I’m working on. As of right now, I have a number of projects I’ve begun and a few that are finished. One of which is a young adult, dystopian thriller set in the future where the population dwindles above extinction. Just to give you all a taste of what that entails, let’s just say that repopulating the human race is of dire importance so the government goes to great lengths to make sure it survives. That means plucking healthy people of proper breeding age and thrusting them into a life where that is not only necessary but demanded upon by the founders of the facility. I can’t give away too much, but I will tell you all that I have been sending out queries for this one I’ve titled The Facility. It’s part of a trilogy that I will soon be working on the sequels to. So, that’s it for the night. My heartfelt rant in a nutshell. See you next time!Some of our readers might prefer the rustic touch, but this unique mobile home definitely has charm While some of our readers may prefer a more rustic touch, many modern greenies don’t want to sacrifice style and comfort for their environmental sensibilities. In which case, the Mehrzeller is right up their alley. Resembling a network of cells on wheels, this contemporary caravan by NONSTANDARD has a clean and angular interior. And best of all, digital software allows buyers to tweak the design in accordance with their own needs. Once the buyer works with NONSTANDARD to nip and tuck corners and customize other interior details, the digital model is finalized by the architect to ensure that the resulting design is feasible. All that is left to do then is hook up the geometric dwelling to a trailer hitch and drive it down the road. As mobility becomes an increasingly popular way of life, more people are seeking innovative solutions that combine adventure and security in one tidy home. LEAVE A COMMENT NEW USER CURRENT USERS LOGIN 1 Comment GreenfinchAugust 3, 2012 at 3:33 am This looks like another case of form over function, purely for the sake of it. Green credentials? – What green credentials! It appears to be made from petro-chemical based materials i.e. plastics, is towed by a petrol or diesel vehicle and being bespoke requires additional human energy input and it’s associated costs, in the design and manufacture and has to be ratified by an architect to boot! Imagine the costs and the amount of hot air that would generate. Caravan fail in my opinion.Performance Verification of the Iris iQ200 Sprint Automated Urine Microscopy Analyzer in a Hospital Routine Laboratory. Systematic performance verification is required before a laboratory can introduce a new measurement procedure for reporting results of patient testing. The aim of this study was to determine whether a new Iris iQ200 Sprint automated urine microscopy analyzer (iQ200 Sprint) could be incorporated into our routine laboratory. A total of 421 fresh urine samples were selected from the Affiliated Hospital of Nantong University, including those from healthy individuals and those with a variety of abnormalities to ensure a wide range of results. Precision, recovery, carry-over, linearity and reference interval were verified according to well-established protocols. The repeatability studies found coefficients of variability (CVs) in the range of 10.53% - 20.28% for red blood cells, white blood cells, and squamous epithelial cells, while the CV for the iQ Positive Control sample was 3.23%. The relative bias was 0.5% for the iQ Positive Control sample and no carry-over was detected. Linearity was observed at concentrations of 10 - 2069.5 particles/μL (y = 0.989x + 9.1, R2 = 0.999). The manufacturer's claimed reference interval meets the requirements for medical usefulness. Performance verification is needed before a clinical laboratory can introduce a new measurement procedure. The iQ200 Sprint is sufficiently precise and reliable to be applied in our clinical laboratory.[Dye laser photocoagulation treatment for experimental subretinal neovascularization. 2. Histopathological findings of unsuccess lesions]. We observed the histopathological process in unhealed lesions following photocoagulation treatment for experimental subretinal neovascularization (SRN) in rhesus monkey eyes. Long-lasting SRNs were produced experimentally by the method which we previously reported. These SRNs were treated by a 590nm dye laser beam, and were examined clinically and histopathologically. Lesions in which insufficient photocoagulation treatment was performed showed serous fluid accumulation and fluorescein angiography revealed remaining neovascularization. In these lesions abundant patent neovascularization was seen with proliferation of spindle-shaped fibroblast-like retinal pigment epithelial (RPE) cells in the subretinal space. These metaplastic RPE cells produced matrix and abundant collagen fiber around the cells. The above results showed that insufficient photocoagulation induced neovascularization and proliferation of RPE cells in the subretinal space and promoted the formation of fibrovascular membrane.Q: Display crouton in PreferenceScreen I am using Crouton library to display warning messages to user. In this scenario, I want to display in a particular preference screen. I have written following code in my PreferenceActivity However, the Crouton is only displayed in the first Preference screen and not on the child preference screen where the Crouton is actually triggered. Any ideas to resolve this issue ? findPreference(key.key).setOnPreferenceChangeListener(new OnPreferenceChangeListener() { @Override public boolean onPreferenceChange(Preference preference, Object newValue) { int count = 0; for (ANALYTICS_KEYS key : ANALYTICS_KEYS.values()) { if (appPreferences.getAnalyticProperty(key)) { count++; } } Crouton crouton = null; if (count > 5 && count < 7) { Style.Builder style = new Builder(Style.INFO).setConfiguration(new Configuration.Builder().setDuration(Configuration.DURATION_INFINITE).build()); crouton = Crouton.makeText(DashAnalyticsPreferenceActivity.this, "More than 5 attributes might not be visible", style.build()); } else if (count > 7) { crouton = Crouton.makeText(DashAnalyticsPreferenceActivity.this, "More than 7 attributes are not allowed. Only first 7 will be considered", Style.ALERT); } else Crouton.cancelAllCroutons(); if (crouton != null) { crouton.show(); crouton.setOnClickListener(new View.OnClickListener() { @Override public void onClick(View v) { //Crouton.hide(crouton); } }); } return true; } A: The Crouton gets attached to the Activites view. Thus it will only be displayed in the Activity that has been passed to create it. If you want to display a Crouton in an other Activity you'll have to pass the corresponding Activity to it. Optimize performance. Ensure high quality work & take your company to a whole new level. Increase Quality Increase Capacity Increase Profitability The QM Wizard is a stand-alone module designed to improve quality management in your shop regardless of what system you employ for day-to-day operations. For customers already using MotorBase or My Shop, the QM Wizard is an add-on module designed to share information with MotorBase or My Shop to enhance data collection and reporting features already inherent in those ERP systems.EPL: Manchester United Look To Cash Out On Juan Cuadrado And Daley Blind By Collin Ruby Getty Images Apparently, Manchester United are severely close to signing Fiorentina and Colombian midfielder, Juan Cuadrado. Manchester United boss, Louis Van Gaal has offered a £32 million fee, but Fiorentina has been adamant in asking for nothing less than £
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distances to the polynyas of the deep sea. Genetic analyses have confirmed that belugas of the Beaufort Sea are clearly distinct from those of other Canadian and Alaskan waters, despite they often share a common wintering habitat. The food chain of the Beaufort Sea is relatively simple: It starts with phytoplankton and epontic algae (single-cell algae associated with the lower interface of sea ice), which provide energy to zooplankton, and epontic and coastal amphipods. The latter serve as a food for seabirds and fish, primarily as polar cod and Arctic char. Polar cod is a major food of Arctic char, beluga, narwhal, seabirds and seals, which are dominated by the bearded seal (Erignatus barbatus) and ringed seal (Pusa hispida). Bearded seal and walrus also feed on benthic invertebrates. On top of the food pyramid stands polar bear, which feeds primarily on seals, but also on any large marine mammals when it has a chance, such as carcasses and whales trapped in ice fields. Human activities "There is only one proposed Early-Entry site in eastern Beringia that still has proponents, Bluefish Caves in the Porcupine River Basin, Yukon Territory, Canada. Claims of great antiquity in the area [e.g., 30kya] have a convoluted history. A caribou tibia flesher, the most diagnostic human implement from the Old Crow basin, had been dated at near 28 kya. When redated using accelerator mass spectrometry (AMS) of small amounts of remnant collagen the bone produced a 1.8 kya date (Yesner 1996b:255)". There is no evidence for anomalous occupation of Beaufort coasts in the context of Arctic cultures generally, including the arrival about 4,000 years ago by Paleo-Eskimos such as the Dorset culture, around 1,000 years ago by the Thule and finally by the modern Inuit. From early ages, they practiced fishing – bones of Arctic char were found at the 4,000 years old settlements. While originally they lived nomadic life, later, they started to form permanent settlements. Modern Inuit are mostly concentrated near the Mackenzie River delta. Their population is increasing, but the unemployment rate is relatively high. Bowhead whales were hunted in the sea between 1888 and 1914. This practice stopped, first because of the decline in whale population and then because of government regulations, but resumed in the 1990s. The major settlements along the Beaufort Sea are Tuktoyaktuk (population 930 in 2009) in Canada and Prudhoe Bay, Alaska. Although Prudhoe Bay is permanently populated by only a few people, there are thousands of contract workers in the area employed on petroleum production at the Prudhoe Bay Oil Field, which is on the coastal lowland known as the North Slope. Artificial islands, such as Endicott and Northstar, have been raised near the shores in 1987 and 2001, respectively. The crude oil is transported through the Trans-Alaska Pipeline System to the southern port of Valdez. Fishing and sea hunting are practised by the local inhabitants and have no commercial value, especially after a US moratorium on commercial fishing of the Beaufort Sea, adopted in 2009. Trapping of muskrat at the Mackenzie River delta was the main source of income for the Athabaskan First Nations peoples and Inuit during 1920–1960, but has since declined. Oil and gas exploration The Beaufort Sea contains major gas and petroleum reserves beneath the seabed, a continuation of proven reserves in the nearby Mackenzie River and North Slope. The Beaufort Sea was first explored for sub-shelf hydrocarbons in the 1950s and estimated to contain about of oil and of natural gas under its coastal shelf. Offshore drilling began in 1972; about 70 wells were set up by the 1980s and 200 wells by 2000. These activities resulted in dredging of about 46.5 million m3 of sea bottom soil, as well as discharge of drilling muds which contained barite, clay, caustic soda, and heavy metals zinc, copper, lead, chromium, cobalt, nickel, cadmium and mercury. About of oil was produced in 1986. A major gas field, named Taglu Gas Field, was discovered in the Mackenzie River delta in 1971, followed by the Parson Lake field and Niglintgak field. The estimated gas reserves of these fields are , and , respectively. Moreover, further into the sea from the Mackenzie delta lies the Amauligak field. This, the largest known oil deposit of the Beaufort Sea, was discovered in 1984, and is estimated to contain of oil and of gas. The development of these fields is hindered by their remote location. This problem was alleviated for Prudhoe Bay by constructing the Trans-Alaska Pipeline, but is limiting regular commercial production at Mackenzie River deposits. For example, the Amauligak Project was started soon after the discovery of the field. In September 1985, the tanker Gulf Beaufort has transported of crude oil to Japan, which was the first shipment of oil from the Arctic deposits. However, the project has stalled after that. In July 2017, the U.S. Bureau of Ocean Energy Management approved a plan to allow Eni, an Italian multinational oil and gas company, to drill four oil exploration wells on Spy Island, one of four artificial islands in the Beaufort Sea. In popular culture Stan Rogers references the Beaufort Sea in his popular Canadian Folk Song Northwest Passage (song). See also Arctic policy of the United States Canadian Internal Waters List of areas disputed by Canada and the United States List of seas Northwest Passage Petroleum exploration in the Arctic References Bibliography L. S. Parsons, William Henry Lear, National Research Council of Canada Perspectives on Canadian marine fisheries management, NRC Research Press, 1993 Further reading External links Sea Ice in the Beaufort Sea from NASA Earth Observatory CAC (Civil Applications Committee)/USGS Global Fiducials Program web page containing scientific description and interactive map viewer featuring declassified high-resolution time-series imagery Category:Canada–United States border disputes Category:Disputed waters Category:Geography of the Inuvialuit Settlement Region Category:Bodies of water of North Slope Borough, Alaska Category:Seas of the Arctic Ocean Category:Seas of the United States Category:Bodies of water of Alaska Category:Arctic Watershed of North America Category:Bodies of water of Yukon Category:Bodies of water of the Northwest Territories Category:Seas of CanadaQ: Trouble understanding on how to calculate all possible events of sample space S While doing some exercises I had following question: How many possible events can be defined if the sample space S looks as follows: $S = \{1,2,3\} $ $S = \{1,2,3,4\} $ $S = \{s_1, ..., s_n\}$ The solution is $8$, $16$, $2^n$. Can someone explain me why the solution is $2^n$? A: I think it’s because each number in the sample space is either part of the event or not, which is two possibilities. So with the three numbers 1, 2 and 3, there are 2 x 2 x 2 possibilities which is 2$^3$ This is then generalized with n numbers to 2$^n$ A: Hint: You can count the events. The sample space $S$ contains $n$ possible outcomes. What is the event space at the first case? It is $\{\emptyset,1,2,3,12,13,23,123\}$. $\emptyset$ is the empty set (Never forget it!). It constains $2^3=8$ events. If you say that $k$ is the number of elements of a sequence then it can be written as a sum: $\sum\limits_{k=0}^n \binom{n}{k}=2^n$. Barcelona vs Juventus 2nd Leg - PES 2017 Penalty Shootout Thursday, January 5, 2017 At CES 2017, which runs from 5 to 8 January in Las Vegas, Google announced the integration of emergency service, the voice assistant Google on Assistant a wide range of additional devices. Google currently Assistant works with devices such as smart speakers the Google Home and Google Pixel. Soon, however, his opportunities will be available on the set-top boxes and TVs with the Android TV platform, including new NVIDIA Shield. In the coming months, Google Assistant will be introduced to telepractice and televisions in the United States based on Android 6.0 Marshmallow or Nougat Android 7.0, such as AirTV Player, Sharp Aquos, Sony Bravia, Xiaomi Mi Box and so on. According to the developers, the NVIDIA Shield will be the first TV-gadget with completely wireless access to Google Assistant, with the possibility of the activation phrase "Ok Google". For other STB and TV may need special voice do. Over time, Google Assistant will be available for smart watch at the upcoming release of Android Wear 2.0, some vehicles with the media based on Android and other devices by using the tools Embedded SDK Google Assistant.The first thing that sprang to mind for me is the possibility of (corporate
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only possible with my consent.If the photos are not taken by me, the source is properly given. If you do not want your pictures published on my blog, please contact me and I will delete them immediately.Thanks. [email protected] information Girls Games Only N/A Description Hey, these celebrities desperately need medical care! Call the Celebrities Doctor to help them! Or you can play doctor games with real surgery on your own! Feel like a professional in this celebrity doctor game! HOW TO PLAY: first of all, choose a character! Then, examine the celebrity and give him or her the remedies from the bottom of the screen. It's an amazing hospital dash in your phone!Look at all the famous people here, screaming "Cure me!". They don't even need the celebrity dress up games, or a celebrity dentist! The surgery simulator is their only way to look fabulous again! And you are the only one to cure an injury or a flue! Celebrities Doctor features:- doctor games for all girls with famous characters- you can guess the celebrity and cure him or her- operations surgery games with a lot of medical instrumentsCome on, try the hospital games in a wonderful design! It's high time to become a real Celebrities Doctor! You can also follow us on Facebook: https://www.facebook.com/GirlsAppsOnly and always remain in touch with up-to-date information about our striking apps and other interesting news! Also you can follow us on Twitter: https://twitter.com/GirlsApps to become an expert in our fascinating apps for girls! - New patients: even more famous and rich!- Modern cure from all sicknesses!- Brand new equipment and meds! Hey, these celebrities desperately need medical care! Call the Celebrities Doctor to help them! Or you can play doctor games with real surgery on your own! Feel like a professional in this celebrity doctor game! HOW TO PLAY: first of all, choose a character! Then, examine the celebrity and give him or her the remedies from the bottom of the screen. It's an amazing hospital dash in your phone!Look at all the famous people here, screaming "Cure me!". They don't even need the celebrity dress up games, or a celebrity dentist! The surgery simulator is their only way to look fabulous again! And you are the only one to cure an injury or a flue! Celebrities Doctor features:- doctor games for all girls with famous characters- you can guess the celebrity and cure him or her- operations surgery games with a lot of medical instrumentsCome on, try the hospital games in a wonderful design! It's high time to become a real Celebrities Doctor! You can also follow us on Facebook: https://www.facebook.com/GirlsAppsOnly and always remain in touch with up-to-date information about our striking apps and other interesting news! Also you can follow us on Twitter: https://twitter.com/GirlsApps to become an expert in our fascinating apps for girls!Reduction of infarct volume and apoptosis by grafting of encapsulated basic fibroblast growth factor-secreting cells in a model of middle cerebral artery occlusion in rats. This study was conducted to evaluate the effects of grafting encapsulated basic fibroblast growth factor (bFGF)-secreting cells in rat brains subjected to ischemic injury. Two cell lines were used for encapsulated grafting in this experiment, namely, a bFGF-secreting cell line established by genetic manipulation of baby hamster kidney (BHK) cells, and a naive BHK cell line. Forty-seven Sprague-Dawley rats were used in this experiment. The animals were divided into the following three groups: those receiving grafts of encapsulated bFGF-secreting cells (BHK-bFGF group); those with grafts of encapsulated naive BHK cells (naive BHK group); and those with no grafts (control group). The authors implanted encapsulated cells into the right striatum of host rats in the BHK-bFGF and naive BHK groups. Six days after grafting, the host and control animals underwent permanent right middle cerebral artery occlusion (MCAO) with an intraluminal suture procedure. The infarct volume was evaluated using 2,3,5-triphenyltetrazolium chloride staining and computerized image analysis 24 hours after MCAO. Fragmentations of DNA in the host brains were analyzed using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling 12 hours after MCAO. The authors found that the infarct volume in the BHK-bFGF group was reduced by approximately 30% compared with that in the naive BHK and control groups. In the ischemic penumbral area, the number of apoptotic cells in the BHK-bFGF group was significantly decreased compared with that in the other groups. The grafting of encapsulated BHK bFGF-secreting cells protected the brain from ischemic injury. Encapsulation and grafting of genetically engineered cells such as bFGF-secreting cells is thus thought to be a useful method for protection against cerebral ischemia.A U.S. House ethics committee on Tuesday announced it’s investigating U.S. Rep. Rod Blum, the incumbent Republican in Iowa’s first congressional district, following news reports earlier this year that he failed to disclose his private business on a required form. The Committee on Ethics for the U.S. House of Representatives said that its top leaders had decided to “extend” a “matter” about Blum. The Office of Congressional Ethics referred the issue to the House committee in July. The office is a nonpartisan, independent entity that reviews allegations of misconduct. The House committee plans to announce “a course of action” on or before Dec. 17, according to the letter. That’s just over a month after the November election, where Blum faces a challenge by state Democratic Rep. Abby Finkenauer. The district, which covers the northeast part of the state, is considered competitive and one of the Democrats’ best chances to reclaim a majority in the House. Tuesday’s release from the ethics committee doesn’t offer more specifics, and notes its existence doesn't indicate a violation has occurred. Blum, however, quickly released a statement confirming the inquiry is related to his disclosure form. Blum accused Finkenauer and other Democrats of waging "a crusade of personal destruction on me and other principled leaders working to drain the swamp in Washington — this is the Swamp fighting back." "Rather than present solutions, the Democratic elite aim to destroy their opponents' reputations through distortions. In my case they scream 'ETHICS VIOLATION!' over a clerical error on a form," Blum added. The Associated Press reported in February that Blum didn’t disclose his role in an internet marketing company he formed. A chief of staff in Blum's congressional office was also featured in a testimonial about the company. Blum, who has repeatedly said the lack of disclosure was an administrative oversight, later amended the form. He reiterated that point in his Tuesday statement and said errors in financial disclosure forms are common. Blum then criticized the press for reporting about the form. "Still, the complicit media continues to take its cues from the Democratic party and they work to make mountains out of molehills in order to deliver an election scandal headline," he said. National Democrats pounced on the Ethics Committee's release. "Rod Blum promised Iowans that he would drain the swamp, now he’s caught swimming in it," said Rachel Irwin, a spokesperson for the Democratic Congressional Campaign Committee. The DCCC is House Democrat's campaign arm.Vladimir SVERDLOV ASHKENAZY, Pianist Born in 1976 in Moscow, Russia. Nephew of the conductor and pianist Vladimir Ashkenazy, also grandson of the pianist and composer David Ashkenazy*. First prize winner of the international competition città di senigallia(Italy,1993), prize winner of the Queen Elizabeth Competition** (Brussels, year 1999), first prize winner of the Prince Albert Award of Piano Master 2006 (Monte Carlo). Performed in several festivals, e.g. Palais Princier de Monaco, Festival de Menton, La Roque d‟Antheron, Progetto Martha Argerich, Festival de Music de Gstaad, Palaces of Saint-Petersburg. Famous for the cycle of pieces for piano opus 4 ***, preludes opus 9 for violin and piano, fantasy opus 11 for violin, viola and piano. Founder of the competition for young pianists, Chiba Festival (Japan, year 2005). Returned to composition inspired by French composer Nicolas Bacri. The constant search for unconventional sound and desire to fuse classical music with modern days technologies, created new pieces intended for theatre, cinema and television.Birthday’s are special for everyone, but for kids it’s more special. They plan it out days and months before in advance all because of excitement. Planing out a party for them is not a bigContinue reading Photo Credit: Wikimedia Commons In May 1968, a well digger named Wilbur Riddle traveled along U.S. Route 25 in the Kentucky backwoods, collecting glass telephone pole insulators. In the midst of his search, he came upon a bundled up green tarp. Riddle nudged the mass with his foot, sending it down an embankment. In the rapid movement, the tarp unraveled
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Harm avoidance, no matter the degree of harm in question, guides clinical decision-making to the exclusion of others values including patient autonomy. The verdure of procreative beneficence and reproductive non-maleficence to support physician refusals in the context of embryo transfer is of questionable strength given two obvious challenges to the theories' admonitions. First, there is the question of by whom and what methodology are benefit and harm measured? The clinician\'s uptake of these theories in defense of treatment refusals could be matched by patient assertions that she is in the best position to adjudge which child will have the best possible life, and that failure to transfer any and all embryos produced causes her tremendous harm. Second, we could---and have---challenge the certainty that transferring an anomalous embryo will produce harm (by the consequence of producing a child with health care needs). The problems of mosaicism and inaccuracies in test results are aspects of this prediction problem, but even when the genetic disorder is correctly diagnosed at the embryo stage, physicians are not always in the best position to predict or judge the quality of life the resulting child will experience. The possibility that the child will endure a difficult life is real, and raises the possibility that the parents may seek legal redress against the physician, despite earlier pleas for assistance and assurances of non-retribution. Concerns about potential legal liability may provide the strongest tug toward transfer refusal. ### C.. Avoiding Legal Liability {#sec2-3-3} Physician concern over potential legal liability for actions taken and decisions made in the course of patient relations is a reality that significantly impacts the practice of medicine.^[118](#fn118){ref-type="fn"}^ Classically, physicians respond to perceived threat of malpractice lawsuit by engaging in defensive medicine---defined by one research group as 'medical practices that may exonerate physicians from liability without significant benefit to patients'.^[119](#fn119){ref-type="fn"}^ These practices are sometimes referred to as assurance behaviors, and include ordering imaging, laboratory tests, specialist referrals, and hospitals admission done to avoid a possible lawsuit.^[120](#fn120){ref-type="fn"}^ Concerns about legal liability are no less robust in the field of infertility care, and may be even greater compared to other specialties because of the unique potential harms at stake.^[121](#fn121){ref-type="fn"}^ Damage calculations, generally limited to harm suffered by the patient, can escalate substantially when an award provides for the lifetime medical and custodial care of a child born with health deficits linked to ART.^[122](#fn122){ref-type="fn"}^ Medical liability claims in the ART sphere can allege a failure to meet the standard of care in both the commission and omission of treatment provided. Narrowing our focus to liability in the context of PGT, claims for the commission of sub-par performance typically allege a provider or laboratory botched the detection of carrier status in one of the intended parents, misread or misreported the results of PGT analysis, or selected the wrong embryo for transfer after testing.^[123](#fn123){ref-type="fn"}^ These claims generally sound in medical malpractice or negligence. Plaintiff harm attributed to omission can raise a physician\'s failure to recommend or offer genetic testing (either of the intended parents or the embryo), failure to inform patients of the inherent risks and errors associated with PGT, or failure to disclose the physician or lab\'s minimal experience in performing genetic testing.^[124](#fn124){ref-type="fn"}^ These claims often fall under the lack of informed consent rubric, and require discernment of both the standard by which disclosure is measured in a particular jurisdiction and whether the particular patient-physician exchange met that standard. In the majority of US states, the standard for informed consent is measured according to a prudent physician standard.^[125](#fn125){ref-type="fn"}^ A court would be asked to discern what a reasonably prudent physician would have disclosed to a patient under similar circumstances. The less-adopted reasonable patient standard requires the physician to disclose those risks and benefits a reasonable patient would deem material to her medical decision-making. With this rough framework in mind, what liability concerns might an infertility specialist dwell upon in either agreeing or refusing to transfer embryos with known genetic anomalies? A crude assessment suggests the potential liability for refusing to make the transfer subjects the provider to a far lower damage calculus than transferring an embryo that results in the birth of a health-affected child. Damage awards for the birth of unhealthy or unwanted children can include the steep costs associated with lifetime medical and custodial costs, as well as damages for loss of consortium or even punitive damages.^[126](#fn126){ref-type="fn"}^ These claims include wrongful life (a claim brought on behalf of the child for damages resulting from being born with a defect due to defendant\'s negligence), wrongful birth (a claim brought on behalf of parents for damages they face as a result of giving birth to and raising a child with health issues), and wrongful conception (a claim for birth of a healthy child whose conception was the result of the defendant\'s negligence).^[127](#fn127){ref-type="fn"}^ On the other hand, claims for refusing to make a requested transfer would likely not include costs associated with child-rearing. Instead, at most, a provider might be assessed the value of a dignitary harm or even the cost associated with procuring the embryo in the first place (essentially reimbursement for the IVF and PGD costs). Perhaps a claim for intentional infliction of emotional distress or conversion could be mounted, but again the value of these claims are likely small in comparison to those that could arise once an unhealthy child is born. While not trivial, a rational assessment of the potential damages associated with complying with a patient\'s request for transfer favors refusal over compliance. This is true even if a patient agrees to waive any future claims against the provider. Such a waiver might be effective to bar the patient\'s future claim after change of heart, but it would be ineffective against a claim by the child---such as a claim for wrongful life---as a parent cannot waive a future child\'s legal claims against the provider.^[128](#fn128){ref-type="fn"}^ Further, some scholars have suggested the physicians who agree to transfer embryos with known, disabling anomalies should be subject to civil or even criminal liability for child abuse.^[129](#fn129){ref-type="fn"}^ Whether legal claims have the potential to be filed by the child, the parents, or the state, physician reluctance to facilitate the birth of an unhealthy child for fear of future liability is a strong disincentive to agreeing to such transfers. Enduring, defending, and possibly reporting such legal claims---even if they fail or prove frivolous---can have lasting impacts on physicians, including their willingness to continue to provide specialty care. Even physicians with deep respect for patient autonomy and the value of reproductive liberty may pause when confronted with the reality that a patient\'s pledge to hold the provider harmless for the consequences of the transfer may later prove to be worthless. Predicting a patient\'s future sentiments about rearing a health-impaired child is as illusive for the provider as it is for the would-be parent. Accurately assessing the exact course of a genetic disease known for deep variation in health impact, as is true in numerous instances, is simply not clinically possible and thus invites uncertainty as to the legal recourse a patient might seek. For this reason, concerns about potential legal liability for embryo transfer stand as a rationale for physician refusal to assist with such patient requests. IV.. Improving the Clinical Landscape {#sec2-4} ------------------------------------- The clinical landscape surrounding patient requests for transfer of anomalous embryos has only recently come into focus. In all likelihood, patients and physicians will face this dilemma with increasing frequency as testing technologies grow more sensitive and greater knowledge surrounding mosaicism emerges. Best practices dictate that clinics debate and develop written guidelines detailing their approach toward patient requests for transfer of embryos determined to be abnormal through preimplantation testing. In so doing, providers can consider the range of arguments in support of assisting and declining to assist in such transfers, as detailed in Parts II and III. In addition, policy makers could consider at least two approaches suggested by professional ART societies and government oversight entities. Both the American and British infertility organizations---the former a voluntary trade group and the latter a national government oversight and licensing authority---have published guidance on the question of abnormal embryo transfer. Given the generally laissez-faire environment in the US surrounding ART regulation, clinics can feel fairly unburdened to draft and implement policies along a broad spectrum of permissiveness and restriction. Deciding where to set the mark may be of matter of physician values and preferences, along with possible market impacts arising from patient behavior in response to announced clinic policies. ### A.. The ASRM View {#sec2-4-1} In May 2017, the American Society for Reproductive Medicine published the opinion of its Ethics Committee on the question of genetically anomalous embryo transfer.^[130](#fn130){ref-type="fn"}^ After setting out the clinical circumstances in which patients request such transfers, followed by the interests and arguments invoked when patients and physicians clash over these transfer decisions, the Ethics Committee sets out its recommendations. Adopting a non-directive approach, the Committee found '\[v\]alid and reasoned argument exist to support provider decision to assist in transferring genetically anomalous embryos, and in declining to assist in such transfers'.^[131](#fn131){ref-type="fn"}^ The only exception to this stance of neutrality involves offspring who are born into extreme illness with no hope for recovery. '\[I\]n circumstances in which a child is highly likely to be born with a life-threatening condition that causes severe and early debility with no possibility of reasonable function
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doing behind the scenes at the club. "We hope that it continues because it is important to go into January with a full squad and we will be losing Gervinho to the Africa Cup of Nations." Wenger is also boosted by news that Olivier Giroud and Tomas Rosicky are available to face Newcastle this weekend after missing the 1-0 win at Wigan through illness. "We should not have any new injuries from our last game," the Frenchman said. "Giroud and Rosicky should be available again. They were sick at Wigan." Rosicky's return has been welcomed by team-mate Santi Cazorla. The 28-year-old has impressed since his summer arrival from Malaga and is looking forward to building up an understanding with the Czech midfielder. "I think that Rosicky is an amazing player, now I have started playing with him because he too has been through a long injury, and he is also a 'Spanish' type of player," Cazorla said. "He associates himself very well, and seeing the positions that we play in, we will understand each other very well, as we do every day during training, and I hope to enjoy many good moments with him on the pitch." Cazorla is hoping he can build up a rapport with Rosicky similar to that already achieved with Jack Wilshere and Mikel Arteta. "Every day that goes by we understand each other better," he added. "It is very easy for me to play with them. "Mikel is more of a tactical player, a very important player in any side. He always has to be well positioned, to cover the open spaces that we leave further up the field. "And Jack is an amazing football player. I did not know him well because when I arrived he was injured, but every day that goes by I understand why he is so well rated here, and especially for what he brings to the team."Q: How do I write many random files to separate drives using Bash? My current script looks like the following: #! /bin/bash for n in {1..10}; do dd if=/dev/urandom of=file$("$n").bin bs=1 count=$(( RANDOM + 1024 )) done It is only writing one file named "file{1..10}" and I have exhausted my limited scripting knowledge trying to fix it. Optimally, I would like to be able to use this script to write as many random files as I would like to any physical drive currently connected to the computer(sda, sdb, sdc). A: the $("$n") make execution which is not necessary: #!/bin/bash for n in {1..10}; do echo $n dd if=/dev/urandom of=file${n}.bin bs=1 count=$(( RANDOM + 1024 )) done Share In a normal winter, Carver said, his herd would be feasting on natural and nutritious green grasses carpeting his winter rangeland about 30 miles north of Bakersfield. But this winter is not normal. Not even close. This land hasn't seen rain of any consequence since late November, when nearly 1 inch fell over a four-day period, according to the National Weather Service. Then it went dry again, and stayed dry, with mere traces of moisture in December and virtually nothing in January. "In most years, it would already be green out here," Carver said, looking around at the dirt-brown hills. "We did have green -- but it didn't last." Instead, Carver and scores of other ranchers in Kern County are in survival mode. Many are buying hay, and lots of it, to feed the animals whose "genetics" have been painstakingly bred over generations. Ranchers from the Temblor Range to the Tehachapis are digging into their reserve funds, turning to banks for loans, or if they're lucky, securing emergency funding from the U.S. Department of Agriculture's Farm Service Agency -- all to buy hay and feed for their cows: their livlihoods, their lives. "I've never seen it this bad," said Glennville rancher Fred Beard, who is in his mid-60s. If the drought extends into a fourth year, "you've got to think about selling out," he said. A brook that runs across Beard's property is not babbling. It's not even whispering, as winter snowfall in the Sierra -- at about 20 percent of normal -- has come to a halt. What grass that is left on Beard's ranch has turned brown. "I had a spring go dry," he said. "But the low country has suffered more, and the west side (of the valley) is really suffering." As caretakers of not just businesses, but proud family traditions, Carver and Beard intend some day to hand off their operations to future generations. No one wants to be remembered as the guy who lost the ranch. So they cull their herds, buy feed, work every day and hang on. "People are selling cattle like crazy," said Jack Lavers, a former president of the Kern County Cattlemen's Association who has sold about 100 of his own cows to cut feed costs and help him ride out the drought. And more cows may need to be sold. Lavers looks for high-quality hay to keep his herd in good shape, but hay prices are higher than they were in previous years as many farmers have shifted from growing hay and other row crops to planting permanent crops, such as grapes or almonds. Lavers pays about $235 a ton, delivered. The number of bales in a ton of hay ranges from about 33 to 50. A herd of 350 head can eat roughly 50 bales a day. Add the cost of specialized protein feeds and it means ranchers, depending on the size of their herds, are dealing with several thousands of dollars per month in additional costs. At the junction of Highway 99 and Famoso Road north of Bakersfield, Justin Mebane was in the saddle Thursday morning, working with a group of cowboys to separate "pairs" -- cow and calf -- from a herd being readied for sale. Mebane, owner-manager of Famoso-Western Stockman's Market, said he's seen a jump in the number of cattle being placed on the auction block. But if the rains and mountain snows don't return, the young cattleman said he's expecting a much more radical spike in sales activity. "This is just the tip of the iceberg," he said. "If we don't get some rain, we're going to get really, really busy. Ranchers will need to liquidate their herds." And that means bringing to an end generations spent building not just the numbers, but the characteristics -- the genetics, as the cattlemen say -- of the herd. If there's any softening of the blow for ranchers, it's that beef prices are at record highs, Mebane said. Cattle on the hoof, going from feedlot to packing plant, are selling at an average of about $1.44 per pound, compared to $1.25 a pound about a year ago. Of course, that's not good news for beef consumers who are seeing prices rise. Drought in Texas, the nation's largest beef producer, had already reduced the number of cattle in the United States. Now it's happening here, too. And fewer cattle translates to higher prices. For Mebane, the situation may prove to be a short-term windfall. But in the long run, he said, it's worrisome. Fewer mother cows in Kern County will result in smaller herds and, ultimately, less commerce. "This is their livelihood," Mebane said of local ranchers. Fortunately, the USDA's Farm Service Agency offers a range of assistance to ranchers in Kern County and throughout drought-stricken California. Val Dolcini, state executive director for the FSA, said the federal-government programs include NAP, the Noninsured Crop Disaster Assistance Program, which provides financial assistance to producers of noninsurable crops when low yields or loss of inventory occur due to a natural disaster. In the case of local ranchers, that crop is natural forage, grasses cattle feed on from the valley floor to the Sequoia National Forest. About 100 ranchers in Kern are eligible for NAP benefits when drought destroys or severely limits livestock forage. Ranchers can buy into the federal insurance for just $250 per year. "Calls to our offices have increased significantly across the state," Dolcini said. Another component of the FSA's safety net for ranchers is called the livestock forage program. It's similar to NAP, but it's connected to the federal farm bill, and the farm bill has been tied up in the U.S. Congress for months. For Carver, whose cows are eating at least $300 per day in profits, being a good caretaker of his family's business means doing whatever it takes to get through this crisis. And driving into the valley every morning, loading up his truck and feeding his cows is part of what it takes. "This is
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and the stone is made as flexible as life in the waists of the bathing-women. One of them, as she steps out, feels the water with her feet, and we feel, with her, a sensation that the water is cold. The coolness of the marble-hall realizes this feeling. Let us go out into the sunshine, and up to the neighbouring cliff, which rises above the mansions and houses. Here the wild roses shoot forth from the crevices in the rock; the sunbeams fall prettily between the splendid pines and the graceful birches, upon the high grass before the colossal bronze bust of Bellmann. This place was the favourite one of that Scandinavian improvisatore. Here he lay in the grass, composed and sang his anacreontic songs, and here, in the summer-time, his annual festival is held. We will raise his altar here in the red evening sunlight. It is a flaming bowl, raised high on the jolly tun, and it is wreathed with roses. Morits tries his hunting-horn, that which was Oberon's horn in the inn-parlour, and everything danced, from Ulla to "Mutter paa Toppen:"[M] they stamped with their feet and clapped their hands, and clinked the pewter lid of the ale-tankard; "hej kara Sjæl! fukta din aske!" (Hey! dear soul! moisten your clay). A Teniers' picture became animated, and still lives in song. Morits blows the horn on Bellmann's place around the flowing bowl, and whole crowds dance in a circle, young and old; the carriages too, horses and waggons, filled bottles and clattering tankards: the Bellmann dithyrambic clangs melodiously; humour and low life, sadness — and amongst others, about " —— hur ögat gret Ved de Cypresser, som ströddes."[N] Painter, seize thy brush and palette and paint the Maenade — but not her who treads the winebag, whilst her hair flutters in the wind, and she sings ecstatic songs. No, but the Maenade that ascends from Bellmann's steaming bowl is the Punch's Anadyomene — she, with the high heels to the red shoes, with rosettes on her gown and with fluttering veil and mantilla — fluttering, far too fluttering! She plucks the rose of poetry from her breast and sets it in the ale-can's spout; clinks with the lid, sings about the clang of the hunting horn, about breeches and old shoes and all manner of stuff. Yet we are sensible that he is a true poet; we see two human eyes shining, that announce to us the human heart's sadness and hope. ## A STORY. All the apple-trees in the garden had sprung out. They had made haste to get blossoms before they got green leaves; and all the ducklings were out in the yard — and the cat too! He was, so to speak, permeated by the sunshine; he licked it from his own paws; and if one looked towards the fields, one saw the corn standing so charmingly green! And there was such a twittering and chirping amongst all the small birds, just as if it were a great feast. And that one might indeed say it was, for it was Sunday. The bells rang, and people in their best clothes went to church, and looked so pleased. Yes, there was something so pleasant in everything: it was indeed so fine and warm a day, that one might well say: "Our Lord is certainly unspeakably good towards us poor mortals!" But the clergyman stood in the pulpit in the church, and spoke so loud and so angrily! He said that mankind was so wicked, and that God would punish them for it, and that when they died, the wicked went down into hell, where they would burn for ever; and he said that their worm would never die, and their fire never be extinguished, nor would they ever get rest and peace! It was terrible to hear, and he said it so determinedly. He described hell to them as a pestilential hole, where all the filthiness of the world flowed together. There was no air except the hot, sulphurous flames; there was no bottom; they sank and sank into everlasting silence! It was terrible, only to hear about it; but the clergyman said it right honestly out of his heart, and all the people in the church were quite terrified. But all the little birds outside the church sang so pleasantly, and so pleased, and the sun shone so warm: — it was as if every little flower said: "God is so wondrous good to us altogether!" Yes, outside it was not at all as the clergyman preached. In the evening, when it was bed-time, the clergyman saw his wife sit so still and thoughtful. "What ails you?" said he to her. "What ails me?" she replied; "what ails me is, that I cannot collect my thoughts rightly — that I cannot rightly understand what you said; that there were so many wicked, and that they should burn eternally! — eternally, alas, how long! I am but a sinful being; but I could not bear the thought in my heart to allow even the worst sinner to burn for ever. And how then should our Lord permit it? he who is so wondrously good, and who knows how evil comes both from without and within. No, I cannot believe it, though you say it." It was autumn. The leaves fell from the trees; the grave, severe clergyman sat by the bedside of a dying person; a pious believer closed her eyes — it was the clergyman's own wife. "If any one find peace in the grave, and grace from God, then it is thou," said the clergyman, and he folded her hands, and read a psalm over the dead body. And she was borne to the grave: two heavy tears trickled down that stern man's cheeks; and it was still and vacant in the parsonage; the sunshine within was extinguished: — she was gone. It was night. A cold wind blew over the clergyman's head; he opened his eyes, and it was just as if the moon shone into his room. But the moon did not shine. It was a figure which stood before his bed — he saw the spirit of his deceased wife. She looked on him so singularly afflicted; it seemed as though she would say something. The man raised himself half erect in bed, and stretched his arms out towards her. "Not even to thee is granted everlasting peace. Thou dost suffer; thou, the best, the most pious!" And the dead bent her head in confirmation of his words, and laid her hand on her breast. "And can I procure you peace in the grave?" "Yes!" it sounded in his ear. "And how?" "Give me a hair, but a single hair of the head of that sinner, whose fire will never be quenched; that sinner whom God will cast down into hell, to everlasting torment." "Yes; so easily thou canst be liberated, thou pure, thou pious one!" said he. "Then follow me," said the dead; "it is so granted us. Thou canst be by my side, wheresoever thy thoughts will. Invisible to mankind, we stand in their most secret places; but thou must point with a sure hand to the one destined to eternal punishment, and ere the cock crow he must be found." And swift, as if borne on the wings of thought, they were in the great city, and the names of the dying sinners shone from the walls of the houses in letters of fire: "Arrogance, Avarice, Drunkenness, Voluptuousness;" in short, sin's whole seven-coloured arch. "Yes, in there, as I thought it, as I knew it," said the clergyman, "are housed those condemned to eternal fire." And they stood before the splendidly-illumined portico, where the broad stairs were covered with carpets and flowers, and the music of the dance sounded through the festal saloons. The porter stood there in silk and velvet, with a large silver-headed stick. "Our ball can match with the King's," said he, and turned towards the crowd in the street — his magnificent thoughts were visible in his whole person. "Poor devils! who stare in at the portico, you are altogether ragamuffins, compared to me!" "Arrogance," said the dead; "dost thou see him?" "Him!" repeated the clergyman; "he is a simpleton — a fool only, and will not be condemned to eternal fire and torment." "A fool only," sounded through the whole house of Arrogance. And they flew into the four bare walls of Avarice, where skinny, meagre, shivering with cold, hungry and thirsty, the old man clung fast with all his thoughts to his gold. They saw how he, as in a fever, sprang from his wretched pallet, and
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Davis's petition could not be construed to assert an ERISA claim and that he should not be permitted to amend his petition in order to include such a claim. These rulings provide the bases for the next two issues. II. Notice Pleading. Our rules, and the cases under them, evidence a liberal view of pleading. Rule of civil procedure 69(a) requires only that a petition include "a short and plain statement of the claim showing that the pleader is entitled to relief." This rule has been interpreted to turn on the reasonableness of the notice conveyed by the petition. The rule does not require the identification of a specific theory of recovery if it advises the defendant of the incident out of which the claim arises and gives fair notice of the general nature of the claim. Stessman v. Black Hawk Broadcasting Co., 416 N.W. 2d 685, 686 (Iowa 1987); Unertl v. Bezanson, 414 N.W.2d 321, 324 (Iowa 1987). Despite the liberality of our pleading rules, however, we still require that a petition give "fair notice" of the claim. Shill v. Careage Corp., 353 N.W.2d 416, 420 (Iowa 1984); Gosha v. Woller, 288 N.W.2d 329, 331 (Iowa 1980). The key in the present case, therefore, is whether Davis's original petition was sufficient to provide fair notice to the defendants that he was making a claim under ERISA. It is clear that an ERISA claim was not in the contemplation of any of the parties at the outset. It was only after Pilot Life was decided in April 1987 that the parties attempted to conform their pleadings to the holding of that case. On May 7, 1987, Blue Cross and the YMCA sought to amend their answers and their previous motions for summary judgment. The court allowed the defendants' amendments. On June 3, 1987, Davis attempted to amend his petition to assert an ERISA claim. This chronology of events is a clear indication that none of the parties, most significantly the defendants, had "fair notice" from Davis's petition of an ERISA claim. It is difficult to believe that a state common-law claim based on negligence and breach of contract could be construed to be fair notice of an intent to rely on a federal statutory claim. In this respect, the present case is similar to Shill, in which the petitioner originally pleaded only negligence and gave no hint of the theory of implied warranty on which the plaintiff attempted to rely. It is also similar to Gosha, in which the plaintiff pleaded only an express warranty and the district court found for him on the basis of implied warrant of habitability. In both of these cases, we held the petitions were inadequate to convey fair notice to the defendants. We reach that same conclusion here. This raises our next issue of whether *14 Davis should have been allowed to amend his petition to assert an ERISA claim. III. The Attempted Amendment. Davis's attempt to amend his petition to assert an ERISA claim, filed approximately 130 days before the trial date, was rejected by the district court which held it would substantially change the issues and would result in a "gross injustice" to the defendants. The amendment basically restated the earlier allegations of the petition but added elements and damage for emotional distress and attorney fees. Davis argues that these changes were not so substantial as to justify rejection of his proposed amendment, pointing to the similarity in the issues and the relatively long time remaining before the date set for trial. He further argues that it was unfair for the court to allow the defendants to amend their answers to assert the preemptive effect of ERISA following Pilot Life and then refuse Davis leave to amend his petition to meet the preemption problem. Iowa Rule of Civil Procedure 88 states that "leave to amend, including leave to amend to conform to the proof, shall be freely given when justice so requires." We have found that amendments are the rule and denials the exception. Ackerman v. Lauver, 242 N.W.2d 342, 345 (Iowa 1976). We have, however, accorded considerable discretion to the trial court rulings on such motions, and will reverse the court only when a clear abuse of discretion has been shown. B & B Asphalt Co. v. T.S. McShane Co., 242 N.W.2d 279, 284 (Iowa 1976). Moreover, an amendment which substantially changes the issues should not be allowed, Ackerman, 242 N.W.2d at 345, nor should amendments be allowed if it is found that the movants were negligent in asserting their cause. See Neylan v. Moser, 400 N.W.2d 538, 543 (Iowa 1987) (record did not support finding seven-month delay in amending claim was negligent). It might be argued that Davis was negligent in not asserting his ERISA claim in his original petition. As he concedes, Pilot Life did not create new law; it only interpreted an existing one. His motion to amend came approximately one month after the defendants had moved to amend their answer to conform to Pilot Life and two months after Pilot Life was decided. We do not believe Davis was negligent in failing to foresee the preclusive effect given to ERISA under the Pilot Life decision. It seems that all parties were caught by surprise. As to Davis's amendment substantially changing the issues, what ERISA requires is that every employee benefit plan ... comply with Department of Labor regulations on giving notice to any participant or beneficiary whose claim for benefits has been denied, and affording a reasonable opportunity for review of the decision denying the claim. Under the civil enforcement provisions of § 502(a), a plan participant or beneficiary may sue to recover benefits due under the plan, to enforce the participant's rights under the plan, or to clarify rights to future benefits. Relief may take the form of accrued benefits due, a declaratory judgment on entitlement to benefits, or an injunction against a plan administrator's improper refusal to pay benefits.... In an action under these civil enforcement provisions, the court in its discretion may allow an award of attorney's fees to either party. Pilot Life, 481 U.S. at 53, 107 S.Ct. at 1556, 95 L.Ed.2d at 51. It is unlikely that the defendants would have "wasted" any discovery in preparing to defend against the common-law claims were an ERISA amendment allowed. The evidence supporting and refuting the common-law and ERISA claims would be virtually identical. The bottom line on the amendment issue is whether the district court abused its discretion in refusing it. Abuse of discretion does not entail ill will, improper motive, or intentional wrong. We have held that discretion is abused when it is exercised on clearly untenable grounds or to a clearly unreasonable extent. Ashmead v. Harris, 336 N.W.2d 197, 199 (Iowa 1983) (abuse of discretion found in district court's compelling production of documents prepared *15 in anticipation of litigation); Hubby v. State, 331 N.W.2d 690, 697 (Iowa 1983). We have stated the test another way—that an abuse of discretion is found where the discretion is exercised on grounds or for reasons clearly unreasonable. Sheer Constr. Co. v. W. Hodgman & Sons, Inc., 326 N.W.2d 328, 334 (Iowa 1982). A United States Supreme Court case, Foman v. Davis, 371 U.S. 178, 83 S.Ct. 227, 9 L.Ed.2d 222 (1962), involved a claim of abuse of discretion in denying leave to amend a complaint pursuant to Federal Rule of Civil Procedure 15(a), quite similar to Iowa Rule of Civil Procedure 88. Under the federal rule, leave to amend is a matter left to the district court's discretion, as it is in Iowa. In Foman, the complainant originally alleged an express agreement by the complainant's father not to make a will, thus assuring the complainant of an intestate share as payment for her services on behalf of her mother. The complaint was dismissed on the basis of a state statute of frauds. Foman moved to vacate the judgment and amend her petition to allege the theory of quantum meruit. The district court denied her motions, and the court of appeals affirmed. Because an express contract could not survive a statute-of-frauds objection and the quantum meruit amendment had been denied, Foman was effectively foreclosed from pursuing any theory. The Supreme Court said: The Court of Appeals ... erred in affirming the District Court's denial of petitioner's motion to vacate the judgment in order to allow amendment of the complaint. As appears from the record, the amendment would have done no more than state an alternative theory for recovery. [Federal r]ule 15(a) declares that leave to amend "shall be freely given when justice so requires"; this mandate is to be heeded.... If the underlying facts or circumstances relied upon by a plaintiff may be a proper subject of relief, he ought to be afforded an opportunity to test his claim on the merits. In the absence of any apparent or declared reason—such as undue delay, bad faith or dilatory motive on the part of the movant, repeated failure to cure deficiencies by amendments previously allowed, undue prejudice to the opposing party by virtue of allowance of the amendment, futility of amendment, etc.—the leave sought should, as the rules require, be "freely given." Of course, the grant or denial of an opportunity to amend is within the discretion of the District Court, but outright refusal to grant the leave without any justifying reason appearing for the denial is not an exercise of discretion; it is merely abuse of that discretion and inconsistent with the spirit of the Federal Rules. Id. at 182, 83 S.Ct. at 230, 9 L.Ed.2d at 226. The present case is similar to
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or all of the following: * A toolchain * A bootloader * A kernel * A root filesystem Building from upstream source code is important for a number of reasons. It means that you have peace of mind that you can rebuild at any time, without external dependencies. It also means that you have the source code for debugging and also that you can meet your license requirements to distribute the code to users where necessary. Therefore, to do its job, a build system has to be able to do the following: 1. Download the source code from upstream, either directly from the source code control system or as an archive, and cache it locally. 2. Apply patches to enable cross compilation, fix architecture-dependent bugs, apply local configuration policies, and so on. 3. Build the various components. 4. Create a staging area and assemble a root filesystem. 5. Create image files in various formats ready to be loaded onto the target. Other things that are useful are as follows: 1. Add your own packages containing, for example, applications or kernel changes. 2. Select various root filesystem profiles: large or small, with and without graphics or other features. 3. Create a standalone SDK that you can distribute to other developers so that they don't have to install the complete build system. 4. Track which open source licenses are used by the various packages you have selected. 5. Have a user-friendly user interface. In all cases, they encapsulate the components of a system into packages, some for the host and some for the target. Each package is defined by a set of rules to get the source, build it, and install the results in the correct location. There are dependencies between the packages and a build mechanism to resolve the dependencies and build the set of packages required. Open source build systems have matured considerably over the last few years. There are many around, including the following: * **Buildroot** : This is an easy-to-use system using GNU make and Kconfig (<https://buildroot.org/>) * **EmbToolkit:** This is a simple system for generating root filesystems; the only one so far that supports LLVM/Clang out of the box (<https://www.embtoolkit.org>) * **OpenEmbedded:** This is a powerful system, which is also a core component of the Yocto Project and others (<http://openembedded.org>) * **OpenWrt:** This is a build tool oriented towards building firmware for wireless routers (<https://openwrt.org>) * **PTXdist:** This is an open source build system sponsored by Pengutronix (<http://www.pengutronix.de/software/ptxdist/index_en.html>) * **The Yocto Project:** This extends the OpenEmbedded core with metadata, tools and documentation: probably the most popular system (<http://www.yoctoproject.org>) I will concentrate on two of these: Buildroot and the Yocto Project. They approach the problem in different ways and with different objectives. Buildroot has the primary aim of building root filesystem images, hence the name, although it can build bootloader and kernel images as well. It is easy to install and configure and generates target images quickly. The Yocto Project, on the other hand, is more general in the way it defines the target system, and so it can build fairly complex embedded devices. Every component is generated as a binary package, by default, using the RPM format, and then the packages are combined together to make the filesystem image. Furthermore, you can install a package manager in the filesystem image, which allows you to update packages at runtime. In other words, when you build with the Yocto Project, you are, in effect, creating your own custom Linux distribution. # Package formats and package managers Mainstream Linux distributions are, in most cases, constructed from collections of binary (precompiled) packages in either RPM or DEB format. RPM stands for the Red Hat package manager and is used in Red Hat, Suse, Fedora, and other distributions based on them. Debian and Debian-derived distributions, including Ubuntu and Mint, use the Debian package manager format, DEB. In addition, there is a light-weight format specific to embedded devices known as the **Itsy package format** or **IPK** , which is based on DEB. The ability to include a package manager on the device is one of the big differentiators between build systems. Once you have a package manager on the target device, you have an easy path to deploy new packages to it and to update the existing ones. I will talk about the implications of this in Chapter 8, _Updating Software in the Field_. # Buildroot The Buildroot project website is at <http://buildroot.org>. The current versions of Buildroot are capable of building a toolchain, a bootloader, a kernel, and a root filesystem. It uses GNU `make` as the principal build tool. There is good online documentation at <http://buildroot.org/docs.html>, including _The Buildroot user manual_ at <https://buildroot.org/downloads/manual/manual.html>. # Background Buildroot was one of the first build systems. It began as part of the uClinux and uClibc projects as a way of generating a small root filesystem for testing. It became a separate project in late 2001 and continued to evolve through to 2006, after which it went into a rather dormant phase. However, since 2009, when Peter Korsgaard took over stewardship, it has been developing rapidly, adding support for `glibc` based toolchains and a greatly increased number of packages and target boards. As a matter of interest, Buildroot is also the ancestor of another popular build system, **OpenWrt** (<http://wiki.openwrt.org>), which forked from Buildroot around 2004. The primary focus of OpenWrt is to produce software for wireless routers, and so the package mix is oriented toward the networking infrastructure. It also has a runtime package manager using the IPK format so that a device can be updated or upgraded without a complete reflash of the image. However, Buildroot and OpenWrt have diverged to such an extent that they are now almost completely different build systems. Packages built with one are not compatible with the other. # Stable releases and long-term support The Buildroot developers produce stable releases four times a year, in February, May, August, and November. They are marked by git tags of the form: `<year>.02`, `<year>.05`, `<year>.08`, and `<year>.11`. From time to time, a release is marked for **Long Term Support** ( **LTS** ), which means that there will be point releases to fix security and other important bugs for 12 months after the initial release. The 2017.02 release is the first to receive the LTS label. # Installing As usual, you can install Buildroot either by cloning the repository or downloading an archive. Here is an example of obtaining version 2017.02.1, which was the latest stable version at the time of writing: **$ git clone git://git.buildroot.net/buildroot -b 2017.02.1** **$ cd buildroot** The equivalent TAR archive is available at <http://buildroot.org/downloads>. Next, you should read the section titled **System requirement** from The Buildroot user manual available at http://buildroot.org/downloads/manual/manual.html, and make sure that you have installed all the packages listed there. # Configuring Buildroot uses the kernel Kconfig/Kbuild mechanism, which I described in the section _Understanding kernel configuration_ in Chapter 4, _Configuring and Building the Kernel_. You can configure Buildroot from scratch directly using `make menuconfig` (`xconfig` or `gconfig`), or you can choose one of the 100+ configurations for various development boards and the QEMU emulator, which you can find stored in the directory, `configs/`. Typing `make list-defconfigs` lists all the default configurations. Let's begin by building a default configuration that you can run on the ARM QEMU emulator: **$ cd buildroot** **$ make qemu_arm_versatile_defconfig** **$ make** You do not tell `make` how many parallel jobs to run with a `-j` option: Buildroot will make optimum use of your CPUs all by itself. If you want to limit the number of jobs, you can run `make menuconfig` and look under the Build options. The build will take half an hour to an hour or more depending on the capabilities of your host system and the speed of your link to the internet. It will download approximately 220 MiB of code and will consume about 3.5 GiB of disk space. When it is complete, you will find that two new directories have been created: * `dl/:` This contains archives of the upstream projects that Buildroot has built * `output/:` This contains all the intermediate and final compiled resources You will see the following in `output/`: * `build/`: Here,
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.E.P., 825 A.2d 1266, 1272 (Pa. Super. 2003). With respect to subsection 2511(a)(1), our Supreme Court has Held that [o]nce the evidence establishes a failure to perform parental duties or a settled purpose of relinquishing parental rights, the court must engage in three lines of inquiry: (1) the parent’s explanation for his or her conduct; (2) the post-abandonment contact between parent and child; and (3) consideration of the effect of termination of parental rights on the child pursuant to Section 2511(b). In re Adoption of Charles E.D.M., 708 A.2d 88, 92 (Pa. 1988) (citation omitted). Further, the trial court must consider the whole history of a given case and not mechanically apply the six-month statutory provision. The court must examine the individual circumstances of each case and consider all explanations offered by the parent facing termination of his or her parental rights, to determine if the evidence, in light of the totality of the circumstances, clearly warrants the involuntary termination. - 10 - J-A31006-15 J-A31007-15 In re N.M.B., 856 A.2d 847, 854-855 (Pa. Super. 2004) (citations omitted). In regard to incarcerated persons, our Supreme Court has stated that incarceration is a factor, and indeed can be a determinative factor, in a court’s conclusion that grounds for termination exist under § 2511(a)(2) where the repeated and continued incapacity of a parent due to incarceration has caused the child to be without essential parental care, control or subsistence and that [sic] the causes of the incapacity cannot or will not be remedied. In re Adoption of S.P., 47 A.3d 817, 828 (Pa. 2012). ... [W]e now definitively hold that incarceration, while not a litmus test for termination, can be determinative of the question of whether a parent is incapable of providing “essential parental care, control or subsistence” and the length of the remaining confinement can be considered as highly relevant to whether “the conditions and causes of the incapacity, abuse, neglect or refusal cannot or will not be remedied by the parent,” sufficient to provide grounds for termination pursuant to 23 Pa.C.S. § 2511(a)(2). See e.g. Adoption of J.J., [511 Pa. at 605], 515 A.2d at 891 (“[A] parent who is incapable of performing parental duties is just as parentally unfit as one who refuses to perform the duties.”); [In re:] E.A.P., [944 A.2d 79, 85 (Pa. Super. 2008)] (holding termination under § 2511(a)(2) supported by mother’s repeated incarcerations and failure to be present for child, which caused child to be without essential care and subsistence for most of her life and which cannot be remedied despite mother’s compliance with various prison programs). If a court finds grounds for termination under subsection (a)(2), a court must determine whether termination is in the best interests of the child, considering the developmental, physical, and emotional needs and welfare of the child pursuant to § 2511(b). In this regard, trial courts must carefully review the individual circumstances for every child to determine, inter alia, how a parent’s incarceration will factor into an assessment of the child’s best interest. - 11 - J-A31006-15 J-A31007-15 Id., at 830-831.5 The Adoption Act provides that a court “shall give primary consideration to the developmental, physical and emotional needs and welfare of the child.” 23 Pa.C.S.A. § 2511(b). The Adoption Act does not make specific reference to an evaluation of the bond between parent and child but our case law requires the evaluation of any such bond. See In re E.M., 620 A.2d 481 (Pa. 1993). However, this Court has held that the court is not required by statute or precedent to order a formal bonding evaluation performed by an expert. See In re K.K.R.-S., 958 A.2d 529, 533 (Pa. Super. 2008). The court first addressed the question of the change of Child’s goal. [Father] is admittedly not a resource for [Child] at this point in time and cannot be available to be a resource until, optimistically, October of 2019, but possibly never. Reunification with [Father] cannot be achieved in a reasonable amount of time. Therefore, a change of the court-ordered goal is necessary to achieve permanency for [Child]. The feasible goals at this point, considering the age of [Child] and the circumstances of this case, are adoption and placement with a fit and willing relative. The [c]ourt recognizes that [Father] objects to placement of [Child] with his brother – although [Father] was the individual who first offered that individual as a resource – but his brother is not the only relative proposed. In fact, [Father] himself has recommended placement with his sister 5 In In re Adoption of S.P., 47 A.3d 817, 822 (Pa. 2012), the Court cited its decision in In re: Adoption of McCray, 331 A.2d 652, 655 (Pa. 1975), for the proposition that termination may be appropriate for an incarcerated parent who has failed to perform his parental duties for a six-month period of time. See id., at 828. S.P. was written in the context of section 2511(a)(2), but applies as well to section 2511 (a)(1). - 12 - J-A31006-15 J-A31007-15 who resides in Kentucky and an ICPC[6] has been initiated. The Adoption and Safe Families Act requires the court to set feasible goals to establish permanency for [C]hild. This [c]ourt, therefore, respectfully requests that the Superior Court affirm its Order changing [Child’s] goal so that placement of [Child] with a safe, permanent resource can be pursued. TCO, at 2. At a permanency hearing, the court must consider the following factors. (f) Matters to be determined at permanency hearing.-- At each permanency hearing, a court shall determine all of the following: (1) The continuing necessity for and appropriateness of the placement. (2) The appropriateness, feasibility and extent of compliance with the permanency plan developed for the child. (3) The extent of progress made toward alleviating the circumstances which necessitated the original placement. (4) The appropriateness and feasibility of the current placement goal for the child. (5) The likely date by which the placement goal for the child might be achieved. (5.1) Whether reasonable efforts were made to finalize the permanency plan in effect. ... 42 Pa.C.S.A. § 6351(f)(1)-(5.1). The court’s findings make clear that, given Father’s incarceration, Child’s placement in foster care is entirely appropriate, (1). Father’s 6 ICPC stands for, “Interstate Compact on the Placement of Children” - 13 - J-A31006-15 J-A31007-15 incarceration prohibits him from complying with CYF’s permanency plan, (2). Father has made little, if any progress toward alleviating the circumstances that necessitated Child’s placement, (3). Child’s goal of reunification was inappropriate and unfeasible, (4). The likely date by which Child might be reunited with Father was at some time in October of 2019 and, by Father’s admission, he may serve a life sentence and never be reunited with Child, (5). CYF has done all that it could do to assist Father in completing the permanency plan, (5.1). To continue to attempt to reunite Child with Father would mean that Child would remain in foster care for at least the next four years—and possibly many more
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); } else if (strncmp(type_string.GetString(), "indexed_triangle_mesh", 21) == 0) { result = parse_indexed_triangle_mesh(obj); } else { throw std::runtime_error(""); } // Parse common node properties if (obj.HasMember("name")) { assert(result != nullptr); rapidjson::Value const& name = obj["name"]; result->name() = name.GetString(); } if (obj.HasMember("children")) { assert(result != nullptr); rapidjson::Value const& children = obj["children"]; parse_children(result, children); } } else { throw std::runtime_error(""); } return result; } template <typename Object> std::shared_ptr<sg::node> vsnray_parser::parse_camera(Object const& obj) { auto cam = std::make_shared<sg::camera>(); vec3 eye(0.0f); parse_optional(eye, obj, "eye"); vec3 center(0.0f); parse_optional(center, obj, "center"); vec3 up(0.0f); parse_optional(up, obj, "up"); float fovy = 45.0f; parse_optional(fovy, obj, "fovy"); float znear = 0.001f; parse_optional(znear, obj, "znear"); float zfar = 1000.0f; parse_optional(zfar, obj, "zfar"); recti viewport(0, 0, 0, 0); parse_optional(viewport, obj, "viewport"); float lens_radius = 0.1f; parse_optional(lens_radius, obj, "lens_radius"); float focal_distance = 10.0f; parse_optional(focal_distance, obj, "focal_distance"); float aspect = viewport.w > 0 && viewport.h > 0 ? viewport.w / static_cast<float>(viewport.h) : 1; cam->perspective(fovy * constants::degrees_to_radians<float>(), aspect, znear, zfar); if (viewport.w > 0 && viewport.h > 0) { cam->set_viewport(viewport); } cam->set_lens_radius(lens_radius); cam->set_focal_distance(focal_distance); cam->look_at(eye, center, up); return cam; } template <typename Object> std::shared_ptr<sg::node> vsnray_parser::parse_include(Object const& obj) { auto inc = std::make_shared<sg::node>(); if (obj.HasMember("path")) { std::string path_string(obj["path"].GetString()); boost::filesystem::path p(path_string); if (!p.is_absolute()) { // Extract base path boost::filesystem::path bp(filename_); bp = bp.parent_path(); // Append path to base path p = bp / p; path_string = p.string(); } model mod; if (mod.load(path_string)) { if (mod.scene_graph == nullptr) { std::unordered_map<std::string, std::shared_ptr<sg::texture2d<vector<4, unorm<8>>>>> texture_map; for (auto it = mod.texture_map.begin(); it != mod.texture_map.end(); ++it) { auto tex = std::make_shared<sg::texture2d<vector<4, unorm<8>>>>(); tex->name() = it->first; tex->resize(it->second.width(), it->second.height()); tex->reset(it->second.data()); tex->set_filter_mode(it->second.get_filter_mode()); tex->set_address_mode(it->second.get_address_mode()); texture_map.insert(std::make_pair(it->first, tex)); } if (mod.primitives.size() > 0) { // Vertices (disassemble triangles..) for (auto tri : mod.primitives) { if (tri.geom_id >= inc->children().size()) { auto props = std::make_shared<sg::surface_properties>(); // Add material auto obj = std::make_shared<sg::obj_material>(); obj->ca = mod.materials[tri.geom_id].ca; obj->cd = mod.materials[tri.geom_id].cd; obj->cs = mod.materials[tri.geom_id].cs; obj->ce = mod.materials[tri.geom_id].ce; obj->cr = mod.materials[tri.geom_id].cr; obj->ior = mod.materials[tri.geom_id].ior; obj->absorption = mod.materials[tri.geom_id].absorption; obj->transmission = mod.materials[tri.geom_id].transmission; obj->specular_exp = mod.materials[tri.geom_id].specular_exp; obj->illum = mod.materials[tri.geom_id].illum; props->material() = obj; bool insert_dummy = false; if (tri.geom_id < mod.textures.size()) { // Find texture in texture_map bool found = false; for (auto it = mod.texture_map.begin(); it != mod.texture_map.end(); ++it) { auto ref = texture_ref<vector<4, unorm<8>>, 2>(it->second); if (ref.data() == mod.textures[tri.geom_id].data()) { std::string name = it->first; // Find in local texture map auto res = texture_map.find(name); if (res != texture_map.end()) { props->add_texture(res->second); found = true; break; } } } if (!found) { insert_dummy = true; } } else { insert_dummy = true; } if (insert_dummy) { // Add a dummy texture vector<4, unorm<8>> dummy_texel(1.0f, 1.0f, 1.0f, 1.0f); auto tex = std::make_shared<sg::texture2d<vector<4, unorm<8>>>>(); tex->resize(1, 1); tex->set_address_mode(Wrap); tex->set_filter_mode(Nearest); tex->reset(&dummy_texel); props->add_texture(tex); } // Add to scene graph props->add_child(std::make_shared<sg::triangle_mesh>()); inc->add_child(props); } auto mesh = std::dynamic_pointer_cast<sg::triangle_mesh>( inc->children()[tri.geom_id]->children()[0] ); vec3 verts[3] = { tri.v1, tri.v1 + tri.e1, tri.v1 + tri.e2 }; mesh->vertices.insert(mesh->vertices.end(), verts, verts + 3); if (mod.shading_normals.size() > tri.prim_id * 3 + 3) { for (int i = 0; i < 3; ++i) { mesh->normals.push_back(mod.sh
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that would be Dow 36,000 - even while wiping out 80% of real investment values. How Inflation Hid A 70% Market Loss: 1968-1982 History has already shown us what can happen to long term investment returns when persistent high inflation collides with stubborn high unemployment, resulting in stagflation. Consider the graph below. As shown in yellow, the Dow Jones Industrial Average reached 919 in May of 1968, and by August of 1982, had fallen to a level of 777, for a loss of 15%. Many investors recall a previous "Lost Decade" for the stock market when the market stayed flat to somewhat down, moving sideways but never persistently up, and what is seen in yellow is consistent with that market perception. Except - a 15% loss in a long-term sideways market isn't what happened at all, not when we look at what a dollar would buy. That is, a US dollar in 1982 was only worth 35 cents compared to what it would have bought in 1968, because the dollar had lost 65% of its value to inflation. As shown in blue in the graph, when we adjust the August, 1982 Dow index of 777 to account for a dollar being worth 35 cents, then the real value of the Dow drops to 274. So when we consider the purchasing power of the dollar, then our stock portfolio wasn't remotely close to flat, but rather had dropped by a staggering 70% in fourteen years, from 919 to 274. This 70% decline in the value of what our assets would buy for us was entirely real, but to this day, many of us don't realize just how bad it was - because inflation in prices was hiding deflation in investment values. The 65% plunge in the value of the dollar "hid" the great majority of the 70% plunge in the value of stocks, with most of the surface value of the Dow index by 1982 consisting of dollars that were worth far less than what they had been before. Three False Peaks & Inflation Hiding Deflation Even though long-term asset deflation of 70% (in real terms) was the result of the last time we had persistent high unemployment coupled with inflation, many investors and newspaper readers of a certain age may not remember the 1970s that way at all. Instead they may recall three powerful bull markets when the Dow repeatedly flirted with the "magical" 1,000 mark. Each surge filled innumerable financial columns with the hopes that the good times and a long term bull market had returned again, with those hopes being quickly dashed as the market repeatedly proved unable to sustain itself above the 1,000 level. The reality is that there never were three bull markets, but rather only an inflationary illusion fooling the public. Indeed when we look closely, instead of seeing three peaks, we will see three historical object lessons in how destroying the value of money can hide the destruction of the value of assets - and repeatedly fool the headline writers along with much of the investing public. The cold reality of the Dow adjusted for inflation is shown in blue. There aren't three interim peaks, but merely a market moving steadily and powerfully down. The "bull market" that peaked in January of 1973 when the Dow hit 1,047 - was in a reality a fall to Dow 848 (asset deflation in inflation-adjusted terms), that was masked by the dollar being worth only 81 cents when compared to May of 1968 (monetary inflation). Inflation had created an almost 200 point illusion in the Dow. The "bull market" that peaked in September of 1976 at 1,014, really represented the Dow falling by over 300 points - translating to asset deflation of 34% - which was hidden from savers by the illusory profit created as a result of the dollar dropping in value by 40% (monetary inflation). The cruelest illusion of all was the "bull market" of April of 1981, when the Dow finally reached 1,024. Because the real value of the market had fallen to 399, and a 57% destruction of the purchasing power of investor assets was being entirely hidden by the 61% destruction of the value of investor dollars. Fully understanding this relationship of simultaneous monetary inflation and asset deflation is absolutely essential for financial survival, because there is a very good chance that we may all be seeing the greatest "bull market" in stocks that we have ever seen in the years ahead. (We will use "monetary inflation" interchangeably with "price inflation" herein.) Three Wealth Destroyers vs "Perfect Timing" In my opinion, the greatest threat to long-term and retirement investors is the wealth-destroying triple combination of monetary inflation, asset deflation, and inflation taxes. One of the most common investor approaches to a truly difficult market is to attempt to "outrun" the problems. Just make better decisions than the rest of the public, and make so much money that the problems can be overcome and wealth kept intact. How well does that work in practice and just how good do you (or your financial advisor) have to be? To answer that question, we will go back in history and assume that through the use of a time machine (or peerless skill, or uncanny luck) we did a perfect job of long-term market timing during an environment of asset deflation and monetary inflation. Aided by this time machine, we put every dollar we had into the market on May 26, 1970, when the Dow closed at 631. What makes this day remarkable is that 631 is the lowest level the Dow index closed at between November 20, 1962 and September 12, 1974. It was the single cheapest day to buy stocks over an almost 12 year time period, and at the time, the lowest that stock prices had been at in more than 7 years. Perfection. Subject to the conditions that 1) as long-term investors we need to be in the market ten or more years, and 2) that we want to stay within the 1968 - 1982 period of sustained asset deflation and high monetary inflation, we instruct our time machine to find the best possible place to sell. This turns out to be April 27, 1981, when the Dow closed at 1,024. April 27, 1981 was the single highest close for the Dow index between January 22, 1973 and October 19th, 1982. So we buy in on the exact day with the lowest stock prices in an almost 12 year period, and we sell everything out on the exact day with the highest prices over an almost a ten year period. Double perfection! So then, how did we do? As shown in the following graph, which begins on our purchase date and ends on our sale date - our time machine allowed us to get the best possible results in a thoroughly bad market. If our returns had exactly tracked the Dow between when we bought and sold, our perfect timing would have taken us from 631 to 1024, for a 62% price gain in the midst of one of the worst markets in memory. A whopping profit indeed! Before we adjust for inflation, that is, so let's do that. A dollar on our sale date in April of 1981 was only worth 43 cents compared to what it was worth on our purchase date in 1970. When we adjust for what our assets will buy for us - we have Dow 440, not Dow 1024. So even the perfect timing delivered by our time machine leads to a 30% asset deflation loss in real terms, not a 62% gain. The Internal Revenue Service did not "see" these losses, however, but on the contrary, was quite impressed by our remarkable investment prowess. Moreover, taxes were higher back then (when we confine ourselves to federal income tax rates, we truly are at a low level now compared to much of the modern era). Assuming we were in the highest income tax bracket, and traded often enough to pay ordinary income tax rates, then given that the average top income tax rate over that period was 68%, this means that we would have paid out 267 in taxes on our 393 gain. These taxes on effectively non-existent income are known to economists as "inflation taxes", and during times of high inflation, they can be devastating. Subtracting out real taxes on imaginary income leaves us with Dow 757 in after-tax terms, and Dow 325 in after-inflation and after-tax terms. Thus, even with our quite unrealistic assumption of absolutely perfect market timing - which allowed us to radically outperform almost every other investor in the nation - we still lost almost half (48%) of the purchasing power of our net worth. Lessons Learned & Implications For Today The most important takeaway from our time machine scenario is not about 1970 or 1981, but about what investors face today. The world has changed immensely, and there are numerous reasons to fear that long term asset deflation could become reality again. And with the fight for survival of both governments and banking systems, that are each effectively dependent on rampant monetary creation and deficits without end - the chances for major inflation have never been higher in the modern era. History does show what can happen next for an entire nation with a deeply troubled economy. For
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parties’ briefs or the appellate record persuades us that there was any error in the district court’s analysis of Ms. Murdock’s claims or in its orders. Therefore, we affirm for substantially the reasons stated by the district court in its order dated March 30, 2011, dismissing some of Ms. Murdock’s claims under Rule 12(b), see Aplt. App. Vol. II, at 16-26, and its order dated September 18, 2012, dismissing the remainder of her claims under Rule 56(a), see id. at 371-92. Entered for the Court Stephen H. Anderson Circuit Judge -6- ###### Strengths and limitations of this study - Designed and reported using Preferred Reporting Items for Systematic Reviews and Meta-Analyses. - Robust search strategy designed by the Specialist Unit for Review Evidence. - Two reviewers checked eligibility of manuscripts. - Two reviewers checked study quality. - Insufficient randomised control trials for a meta-analysis. Introduction {#s1} ============ The incidence of musculoskeletal pain is known to be high globally, and to be a significant factor in causing disability through reduced functioning and lower levels of general well-being. In 2016, musculoskeletal problems were the second most common cause of work-related absence in the UK, with an estimated 30.8 million days lost.[@R1] The impact on concurrently existing long-term conditions, health resource utilisation and societal impacts such as work disability are considerable.[@R2] Worldwide, musculoskeletal conditions account for 21.3% of the total years lived with disability within the general population,[@R5] but this is even higher in older populations; reaching a high point of 28.5% in the 50--69-year-old age group and 23.4% in the 70-year plus age group.[@R6] As a result, individuals may not be able to be physically active with a possible knock-on effect on the prevention and treatment of other non-communicable diseases.[@R7] Hip and knee osteoarthritis (OA) is one of the most common musculoskeletal conditions and causes chronic joint pain after non-specific low back pain. It has a prevalence of 3.7% in the population, affecting approximately 268 million individuals worldwide. This increases to 14% in individuals over 65 years.[@R6] A number of evidence-based guidelines exist detailing what treatment should be delivered. These centre on the delivery of self-management, education, exercise and joint replacement surgery when needed or at the end stage of OA.[@R9] What is less frequently considered in both research and guidelines is the organisation of care: where it is carried out, how it is done and the complex inter-relationships between these factors and the type of treatment given. For example, the first point of contact for most individuals seeking help for a musculoskeletal condition is usually a general practitioner (GP) in a primary care setting.[@R9] If treatment fails or assessment for surgery is required, then a 'specialist' opinion will be sought, which may occur in primary or secondary care.[@R9] The 'specialist' could be from any one of several healthcare professionals: a physiotherapist, a GP with a specialist interest in musculoskeletal conditions, an advanced nurse practitioner or an orthopaedic surgeon.[@R15] Understanding the variation and interrelationships between how and where treatment is delivered is required in order[@R6] to optimise care around patient outcomes and efficiency in a multilevel whole systems approach.[@R6] At a macro level, there needs to be consideration of the scope and functionality of healthcare policy, healthcare systems and socioeconomic factors. At a 'meso' level, considerations relate to health services, clinical workforce, competencies, education and infrastructure. Finally, at a 'micro' level, considerations relate to the involvement of an individual in their own care.[@R6] Applying this to care pathway research helps to identify where the evidence already exists and enables more effective research planning. This review will focus on the care pathway for chronic hip and knee pain for adults referred for specialist opinion. The joint-specific focus at this point in the care pathway recognises the rising demand for both care and joint replacement surgery in this group, which is associated rising healthcare costs.[@R19] Thus, the following are the aims of this review:to understand the evidence for the clinical and/or cost effectiveness of current care pathways for adults with chronic hip/knee pain patients accessing care for specialist opinion.to identify the key information required to inform effective referral decisions for specialist opinion. Methods {#s2} ======= This systematic review is reported in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidance.[@R20] A protocol with full details of the methodology for this systematic review, including the search terms used has been published, so only a brief overview is provided here.[@R21] Search strategy {#s2a} --------------- Searches were undertaken without language restrictions for both published and grey literature that considered models of service delivery and care pathways. All sources were searched for evidence published between 1 January 1990 and 20 December 2017. The following databases were searched: Medline, Medline in Process, Cumulative Index of Nursing and Allied Health Literature, Embase, Pedro, PubMed, Web of Science, Cochrane Central Register of Controlled Trials and Health Management Information Consortium. In addition, websites were searched for grey literature, care pathways and policy documents. Finally, reference lists were checked and citations tracked for included evidence. Full details of the search, including the Medline search strategy are provided in the published protocol.[@R21] Details of searches for other databases are available on request from the authors. Eligibility {#s2b} ----------- All study designs and documents that considered care pathways for musculoskeletal hip and/or knee pain for adults from the point of referral for specialist opinion meeting the European Pathway Association definition of a care pathway[@R22] were included. No diagnostic criteria were specified as musculoskeletal pathways accept all hip/knee pain without such criteria. Publications were excluded if their primary focus was generalised inflammatory arthropathy, stroke, postsurgical care or musculoskeletal care pathways that did not include hip and knee joint-specific data. Data selection {#s2c} -------------- After duplicate results were removed, two reviewers (KB and Cheryl Cleary, FM) independently considered citations against inclusion/exclusion criteria. At both title/abstract and full-text stages, disagreement was resolved by discussion with a third reviewer. Quality assessment {#s2d} ------------------ Studies were appraised using validated checklists for specific research designs: The Critical Appraisal Skills Programme checklist for randomised controlled trials (RCTs)[@R23] and the Joanna Briggs Institute checklists for qualitative studies, cross-sectional surveys, longitudinal studies and case series.[@R24] After a sample of studies had been piloted to ensure a baseline of understanding and agreement between reviewers, papers were assessed by one reviewer (KB) and checked by a second (FM). Data extraction and synthesis {#s2e} ----------------------------- Data were extracted into a standardised form. After piloting, data extraction was completed by one reviewer (KB) and checked for accuracy by another (FM). The protocol[@R21] specified the utilisation of a mixed-methods approach to data synthesis. However, only one qualitative study was identified. This combined with the low quality and heterogeneity of the evidence precluded any mixed-methods synthesis or meta-analysis. Consequently, the results are presented narratively by primary outcome type reported. These categories were identified inductively from the data: patient flow (the movement of patients between healthcare professionals, services and organisations),[@R25] professional competency (the level of agreement in diagnosis and treatment between Advanced Physiotherapy Practitioners and orthopaedic surgeon or expert physicians), resource use including clinical and cost effectiveness, time (changes in patient waiting times experienced as a direct result of the way the pathway was delivered), patient satisfaction and patient experience. These outcomes are organised according to where they apply in a multilevel, whole systems approach, that is, macro, meso or micro level.[@R6] Patient and public involvement {#s2f} ------------------------------ A patient representative was involved at the planning stages and helped to formulate the aims of this systematic review. Results {#s3} ======= Pathways for the delivery of care for hip and knee pain after referral for specialist opinion have not been widely researched. Although 1248 citations were identified, most of the primary research in this area has looked at generalised pathways for musculoskeletal conditions that are not specific to body regions. In most instances, findings were not disaggregated and therefore were excluded. Thus, of the 140 full-text articles assessed for eligibility, 121 were excluded and only 19 articles reporting the results of 17 studies were included in the analysis (see [figure 1](#F1){ref-type="fig"}). ![Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols flow chart for study selection.](bmjopen-2018-027874f01){#F1} All the included studies were from high income, developed countries: eight from the UK,[@R16] five from Canada,[@R33] two from New Zealand[@R15] and one each from Australia[@R39] and the Netherlands.[@R40] There were some differences in the patient population being evaluated across the studies: seven studies included patients with a knee condition only,[@R26] two studies with a hip condition only[@R16] and
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LUC and CAT activity were measured 16 h after transfection. The LUC/CAT activity ratio is expressed as a percentage of the control (pcDNA3) set at 100%. The experiments were performed four times in duplicate.](200504039f2){#fig2} eIF4E localizes to P-bodies --------------------------- Because 4E-T localizes to P-bodies, and because it interacts with eIF4E, it was pertinent to ask whether eIF4E also localizes to P-bodies, and whether this localization requires 4E-T. To this end, we performed immunofluorescence analysis of endogenous eIF4E in HeLa cells using a monoclonal antibody, which recognizes eIF4E in the cytoplasm ([@bib29]). Although eIF4E is distributed throughout the cytoplasm, it is concentrated in foci reminiscent of P-bodies ([Fig. 3](#fig3){ref-type="fig"} A). This staining pattern is observed in two different HeLa cell sublines: HeLa CCL2 and HeLa S3 ([@bib6]), but with qualitative differences ([Fig. 3, A](#fig3){ref-type="fig"} and B--E, respectively), and in mouse embryo fibroblasts (not depicted). Furthermore, transiently transfected HA-eIF4E also displays a similar cytoplasmic distribution pattern (see below, [Fig. 4](#fig4){ref-type="fig"} A). ![**eIF4E colocalizes with 4E-T, Dcp1a, and Dcp2 in P-bodies.** (A) HeLa cells (CCL2) were fixed and the localization of eIF4E was determined by indirect immunofluorescence with mouse anti-eIF4E monoclonal antibody and Alexa Fluor 594 anti--mouse IgG. The localization of 4E-T was examined with anti--4E-T and that of Dcp2 with anti-Dcp2 and Alexa Fluor 488 anti--rabbit IgG. The colocalization of these factors appears yellow in the merged image. (B) The colocalization of endogenous eIF4E with 4E-T and Dcp1a was examined with anti--4E-T and anti-Dcp1a in HeLa S3 as above. The left panel demonstrates endogenous eIF4E localization in HeLa S3. Zoomed images (right panel) display colocalization of endogenous eIF4E and Dcp1a in P-bodies. Some of the more distinct P-bodies are indicated by arrowheads. (C) HeLa cells were transfected with GFP-4E-T and the staining of endogenous eIF4E was performed with anti-eIF4E antibody as described above. (D) The intensity of fluorescence of endogenous eIF4E in P-bodies from GFP--4E-T--transfected cells (from panel C) was compared against the intensity of fluorescence of eIF4E from nontransfected cells along the path, which is indicated by the arrow. The P-bodies along the path of the arrow are circled in the adjacent panel for comparison for better visibility. The signal was allowed to bleach before quantification to avoid a saturated signal. The graphs plot the intensity of fluorescence against the distance (μm) traversed by the arrow. (E) HeLa cells transfected with GFP-4E-T were incubated with Alexa Fluor 594 anti--mouse IgG (M-AF594) without previous incubation with anti-eIF4E antibody to demonstrate the integrity of the green filter.](200504039f3){#fig3} ![**eIF4E requires interaction with 4E-T for localization to P-bodies, whereas the other components of the eIF4F complex are excluded from P-bodies.** (A) HeLa cells were transfected with HA-eIF4E wt, HA-eIF4E W73A, or HA-4E-T Y30A. Localization of proteins was studied by indirect immunofluorescence with anti-HA (Covance) and Alexa Fluor 594 anti--mouse IgG. (B and C) HeLa cells were transfected with GFP-Dcp1b and staining of endogenous eIF4GI (B) or eIF4A (C) was detected with anti-eIF4GI and Texas Red conjugated anti--rabbit IgG or with anti-eIF4A and Alexa Fluor 594 anti--mouse IgG. (D) HeLa extract (50 and 100 μg) was resolved by SDS-8% PAGE and a Western blot was performed with rabbit anti--eIF4GI polyclonal antibody. For eIF4A detection, proteins were resolved by SDS-10% PAGE and Western blot was performed with a mouse anti-eIF4A monoclonal antibody.](200504039f4){#fig4} Double-label immunofluorescence analysis shows that eIF4E colocalized with 4E-T and Dcp2 in P-bodies ([Fig. 3](#fig3){ref-type="fig"} A). eIF4E exhibited a more pronounced association with P-bodies in CCL2 ([Fig. 3](#fig3){ref-type="fig"} A) as compared with HeLa S3 ([Fig. 3](#fig3){ref-type="fig"} B). eIF4E colocalized with Dcp1a and 4E-T in P-bodies, albeit staining of eIF4E in these structures is not as apparent as the staining of 4E-T and Dcp1a in HeLa S3 ([Fig. 3](#fig3){ref-type="fig"} B). Strikingly, overexpression of GFP--4E-T resulted in enhanced staining of eIF4E in P-bodies ([Fig. 3](#fig3){ref-type="fig"} C). Because localization of eIF4E in P-bodies was more prominent, and the foci appeared larger and brighter in GFP--4E-T overexpressing cells than in parental cells, these data suggest that 4E-T might tether eIF4E to P-body structures. This effect is illustrated in a graph plotting the intensity of the eIF4E signal (red channel) in two P-bodies marked by an arrow in cells overexpressing 4E-T levels ([Fig. 3](#fig3){ref-type="fig"} D, right panel) and in cells expressing endogenous 4E-T levels ([Fig. 3](#fig3){ref-type="fig"} D, left panel; the respective P-bodies traversed by the arrow are circled in the adjacent panel for comparison). The signal intensity of eIF4E was approximately twofold higher in cells overexpressing 4E-T as compared with endogenous 4E-T levels, when P-bodies of weaker intensity were selected from cells overexpressing 4E-T to avoid signal saturation of the plot. Similar results were obtained with a monoclonal antibody against eIF4E from Transduction Laboratories (610270), and with a monoclonal antibody (10C6), which recognizes eIF4E predominantly in the nucleus ([@bib34]; [@bib13]; unpublished data). The enhanced eIF4E signal is not due to leakage of the FITC signal, because no significant signal was detected in the red channel when cells transfected with GFP--4E-T were stained with the secondary antibody alone ([Fig. 3](#fig3){ref-type="fig"} E). To determine whether the association of eIF4E with P-bodies requires its interaction with 4E-T, we performed immunofluorescence analysis using wild-type HA-eIF4E and a mutant lacking the 4E-T binding site (eIF4E W73A) ([@bib12]). Low eIF4E cDNA amounts were transfected transiently into HeLa cells to obtain a predominantly cytoplasmic ([@bib12]) and P-body localization ([Fig. 4](#fig4){ref-type="fig"} A). Cytoplasmic eIF4E levels in HA-eIF4E--expressing cells were similar to endogenous levels. However, a more pronounced cytoplasmic foci staining was observed in ∼40% of the transfected cells, presumably because more eIF4E is expressed in these cells. In contrast, HA-eIF4E W73A did not localize to P-bodies, and was distributed uniformly between the cytoplasm and the nucleus ([Fig. 4](#fig4){ref-type="fig"} A). Therefore, loss of 4E-T interaction (and also interaction with eIF4G and 4E-BPs) ([@bib38]) leads to deregulated cellular localization, which results in diffuse staining throughout the cell. In addition, because the HA--4E-T (Y30A) mutant, which is defective in eIF4E binding ([@bib12]), still localizes to P-bodies, these results suggest that 4E-T is required for the association of eIF4E with P-bodies, but not vice versa (see also [Fig. 5](#fig5){ref-type="fig"} C). ![**Depletion of 4E-T from HeLa cells results in disappearance of decapping factors from P-bodies.** (A) HeLa cells were transfected with siRNA against 4E-T or control siRNAs (4AIII inverted or 4E-T inverted). 48 h after transfection, cells were split into chamber slides for immunofluorescence analysis \[see (C)\] and into a 6-cm dish for Western blot analysis. 60 h after transfection, protein cell extracts were prepared and 20 μg of extract was resolved by SDS-10% PAGE. Western blotting was performed with rabbit anti--4E-T and anti-eIF4E antibodies, or mouse anti--β-actin monoclonal antibody (Sigma-Aldrich). 4E-T levels were quantified against β-actin, which served
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fundamental property of the Gaussian distribution or an issue with numerical accuracy in the computation? I've come across this issue by trying to weight samples from a Gaussian distribution obtained from a Gaussian process prediction, where I will get massive probabilities. Thanks A: The code in the question returns the values of probability density function. The values of probability density function can be greater than one. The actual probability $P(X<x)$ for random variable $X$ with probability density function $p(x)$ is integral $\int_{-\infty}^xp(t)dt$. The values of this integral are of course restricted to interval $[0,1]$. Prince Pompadore is celebrating his eighteenth birthday when out of his birthday cake bursts a magic scroll, a magic mirror, and a doorknob. The scroll warns the young prince that if he does not marry a “proper princess” in a week, his entire kingdom will disappear. With the help of his elephant Kabumpo, Prince Pompadore sets out to Emerald City to find a princess to marry. However, the proper princess that the Prince is searching for may not be who he expects.… (more) Prince Pompadore is celebrating his eighteenth birthday when out of his birthday cake bursts a magic scroll, a magic mirror, and a doorknob. The scroll warns the young prince that if he does not marry a “proper princess” in a week, his entire kingdom will disappear. With the help of his elephant Kabumpo, Prince Pompadore sets out to Emerald City to find a princess to marry. However, the proper princess that the Prince is searching for may not be who he expects. This eBook comes complete with over 100 of the original images that graced the pages of the book when it was first published.Q: What is the best approach here? The question in context is this. I had posted an answer to this question on five months ago. However, a few months later I received a comment on the answer saying that it is not a valid answer. I took this feedback and tried to answer the question again. However, I received a similar comment on my new answer without any explanation. How do I ask the user to give a scenario where the answer won't apply, or what can I do so that answer is best understood by others? Another comment (which gave the scenario where it didn't work) by the same user helped improved the answer though. A: It's their word against yours. Don't focus on one individual too much. If they have a point, they should elaborate. If you think you're correct to the best of your knowledge and nobody has proven you wrong yet, then don't lose sleep over it. If you're indeed wrong, the community is supposed to figure that out and vote and comment accordingly. Just let it go. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. If you continue browsing the site, you agree to the use of cookies on this website. See our User Agreement and Privacy Policy. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. If you continue browsing the site, you agree to the use of cookies on this website. See our Privacy Policy and User Agreement for details. 17. Best of Twitter USE RETWEET AND NOT RT KEEP TWEETS SHORT Retweet drives 23x higher engagement then abbreviation Less than 100characters received more than 17% higher engagement also results in higher RT USE ATLEAST ONE HASHTAG USE IMAGES IN YOUR TWEET Brands that use Twitpics received 2x higher engagement ADD A CALL TO ACTION Call to action increases engagement to 12x higher Brands that use atleast one hashtag received 2x higher engagementFriday, April 13, 2018 Writing Articles as an Affordable Internet Marketing Method From Overture, a keyword suggestion tool, you will see the millions of searches done to a certain keyword. When these keywords are typed on search boxes of search engines, indexed websites containing articles with those keywords will be displayed. And this is what leads traffic to websites with keyword-rich articles. Yes, the magic word is articles. Content is king. You can say that again. That is why writing articles is one of the most utilized Internet marketing media today. Internet surfers just can't get enough of information on various fields. Providing information through these articles is a surefire way to drive hot traffic to your web site. Why is this so? Here are the benefits that writing articles can give your Internet business. 1. It's absolutely free. Too good to be true? Not. Okay, you have to pay for your Internet Service Provider. That's it. All you need is your thoughts, your computer, and your hands. If you have those, nothing will stop you from typing words that will make you complete that article for your website. On which aspect of that process did you really shell out any cent? Maybe later when your electric bills come. 2. Your website will be noticed in a short period of time. Submit that article of yours to article directories that get the most web traffic and in no time your web site will be crawled. That is if you don't forget including your resource box or byline. 3. Obtain back links automatically. When you submit your articles to directories, surely, other websites will make use of your article too. With the copyright terms of your articles, the URL of your website will still be in tact and will subsequently direct more traffic to your website. 4. Improve your reputation. As an Internet marketer, if you plainly display your products on your website, you will not gain much conversion rate. Conversion is when your traffic converts to sales. You have to show that you are knowledgeable on your field. And what better way to show that than by writing articles that will allow you some bragging rights, right? Just make your creative juices flow and jot down or key in those ideas quickly to jumpstart your article writing momentum. With those benefits listed above, a writer's block is the last problem you will ever be able to surmount.Tv Wall Unit is match and guidelines that suggested for you, for motivation about you search. The exactly sizing of Tv Wall Unit was 1920x1080 pixels. You can even look for a few pictures that related to Tv Wall Unit by scroll right down to collection on below this picture. If you wish to find the other picture or article about Tv Wall Unit just drive another button or earlier button; or if you are considering similar pictures of Tv Wall Unit, you are absolve to flick through search feature that situated on top this site or arbitrary post section at below of the post. Hopefully it can benefit someone to get information of the picture. Please if you want the image or gallery that you what I'd like anyone to do is to aid and help us producing more experience by writing this design or clicking some arbitrary posts below for much more pictures and additional information. Furthermore you can help us expand by posting These Resources of Tv Wall Unit on Facebook, Course, Twitter, Yahoo Plus and Pinterest.Cruise control is a popular retrofit for 996 and 986 Boxster models which have drive-by-wire (eGas) throttle systems. This includes 996 Carrera models from MY2000 onwards, Boxsters from MY2000 onwards, and all 996 Carrera 4 cars. If you want to fit cruise, it makes sense to fit the OBC at the same time, as a new 4-stalk control unit is required. We can also retrofit factory cruise control to 997, 991, 987 & 981 Boxster and Cayman models. This includes fitting of the cruise control stalk, and a new lower cover to the steering column. The standard retrofit includes a black plastic cover, but if your car has additional leather trim options fitted, you may want to have a leather lower cover. In this case we can order a matching cover, but this part is much more expensive than the plastic item, and we also require a deposit before ordering.Q: ImportError: cannot import name 'AppLayout' from 'ipywidgets' While importing AppLayout I'm getting the following error. I am using Jupyter and have installed ipywidgets. The same error is being raised when importing GridspecLayout. Can anyone help me with this? All other imports from ipywidgets are working properly, atleast the ones I have imported. ImportError: cannot import name 'AppLayout' from 'ipywidgets' (C:\Appl\Anaconda3\lib\site-packages\ipywidgets\__init__.py) A: Check you have the latest version of ipywidgets with help(ipywidgets). 7.5.2 is required for this (https://github.com/jupyter-widgets/ipywidgets/blob/master/docs/source/changelog.md). Carrinho Capturing the Future Now I am personally interested in random places that have the ‘Blade Runner’ feel,” says Ryan Allen, a PhD student from New York, who co-created the account @bladerunnerreality to post pictures of places that are aesthetically similar to Ridley Scott’s cult film. This is Caption “We realized we had a lot of photos of a certain kind of architecture or lighting which evoked flashbacks of ‘Blade Runner.’ We both loved
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7407, 7938, 34044, 275, 30243, 7891, 685, 26769, 285, 1110, 275, 625, 25979, 2390, 2975, 13, 534, 9945, 281, 253, 50050, 8037, 275, 30243, 7891, 15, 48140, 25930, 275, 30243, 7891, 13, 347, 4080, 407, 7891, 2281, 3910, 13, 671, 42248, 875, 2806, 285, 3168, 7625, 285, 2439, 26367, 2390, 1309, 253, 2469, 1264, 8007, 15, 2053, 7101, 285, 5675, 2675, 25930, 275, 30243, 7891, 6613, 4828, 281, 253, 7342, 273, 253, 3872, 1786, 15952, 326, 5841, 323, 2007, 23082, 390, 20408, 273, 1786, 25930, 275, 253, 1986, 2077, 13, 1690, 1110, 275, 13440, 2728, 13, 407, 9169, 15775, 709, 25, 1184, 187, 187, 23954, 14, 3169, 30270, 3910, 275, 30243, 7891, 2361, 1060, 403, 5185, 342, 1110, 387, 253, 2060, 1268, 15, 46283, 11033, 2728, 7891, 4142, 275, 13842, 14, 14643, 285, 7901, 14, 11496, 407, 2060, 14, 5251, 30270, 285, 18825, 5319, 3559, 11249, 943, 5752, 347, 253, 8245, 941, 323, 5301, 342, 625, 3332, 7891, 956, 14, 484, 941, 275, 253, 27218, 3338, 285, 323, 5301, 342, 5213, 6127, 15775, 709, 1166, 1184, 187, 187, 49497, 900, 17989, 285, 15066, 16, 678, 9335, 43586, 275, 30243, 7891, 4887, 25930, 275, 253, 2675, 3126, 313, 70, 15, 72, 904, 2144, 3811, 2515, 13, 2675, 1329, 13, 285, 4073, 582, 14613, 2495, 2616, 824, 347, 10470, 13, 13833, 13, 3520, 275, 12135, 13, 2728, 8996, 13, 285, 11723, 2289, 285, 1971, 15775, 709, 23, 2947, 709, 24, 2947, 709, 883, 2947, 709, 1047, 1184, 496, 253, 1986, 2077, 13, 15066, 16, 678, 9335, 31691, 824, 347, 26769, 13, 2448, 16869, 16, 2422, 11304, 427, 3993, 13, 285, 3032, 4029, 982, 403, 10260, 12307, 2961, 275, 30270, 49049, 2429, 281, 19991, 15, 1583, 452, 3012, 2406, 4730, 285, 6021, 2308, 285, 2169, 4142, 273, 14192, 13, 20549, 13, 285, 3480, 273, 1786, 6503, 685, 19991, 15775, 709, 18, 2947, 709, 1508, 17548, 709, 1099, 1184, 6408, 253, 2469, 577, 8007, 13, 14192, 4142, 323, 26769, 285, 3032, 4029, 982, 452, 644, 374, 14, 20, 2069, 2169, 685, 253, 2281, 323, 19991, 13, 285, 253, 20549, 2281, 323, 22513, 556, 12724, 644, 7019, 326, 323, 19991, 15775, 709, 18, 2947, 709, 1508, 2947, 709, 1348, 1184, 380, 6832, 3168, 14, 11958, 8037, 275, 8876, 2021, 6021, 556, 32178, 13, 285, 7880, 15066, 3910, 275, 6021, 452, 42248, 689, 673, 15775, 709, 1348, 2947, 709, 1099, 1184, 187, 187, 688, 2087, 13, 16175, 31691, 285, 4292, 342, 2406, 43135, 390, 275, 625, 25979, 3672, 273, 253, 1986, 2077, 452, 3777, 2289, 281, 1786, 1557, 285, 403, 625, 2779, 281, 2273, 2184, 390, 5778, 31382, 390, 3058, 3739, 1557, 685, 616, 625, 4545, 2961, 21421, 15775, 709, 18, 2947, 709, 883, 2947, 709, 938, 1184, 2726, 3777, 2289, 281, 31382, 1557, 285, 2393, 5481, 3238, 13, 4292, 275, 12307, 2961, 15156, 2390, 403, 625, 2779, 281, 320, 11245, 342, 7269, 2728, 285, 452, 2406, 5788, 4142, 1014, 846, 10938, 323, 30270, 5319, 15775, 709, 938, 1184, 187, 187, 51, 19601, 16, 678, 9335, 285, 30270, 6127, 275, 2495, 2616, 824, 347, 10470, 13, 14300, 13, 285, 6658, 13559, 403, 3839, 5185, 342, 1110, 275, 30243, 7891, 15, 3774, 6856, 8996, 310, 2169, 275, 2448, 16869, 16, 2422, 11304, 427, 3993, 13, 19991, 13, 285, 26769, 685, 1284, 2458, 15775, 709, 18, 2947, 709, 1036, 1184, 3774, 6856, 8996, 310, 671, 9619, 2169, 275, 2406, 43135, 2390, 390, 625, 25979, 3672, 13, 285, 556, 13547, 1199, 625, 9086, 275, 2169, 43135, 2390, 685, 275, 625, 12307, 2961, 2390, 15775, 709, 18, 2947, 709, 1036, 1184, 496, 4050, 13, 253, 8996, 273, 14300, 369, 6480, 6, 2169, 275, 26769, 685, 19991, 13, 5727, 1110, 342, 1698, 4730, 285, 2021, 6021, 2308, 574, 271, 5512, 2456, 6, 2169, 8996, 273, 14300, 685, 616, 1698, 14, 52, 1410, 21421, 15775, 709, 1036, 1184, 1707, 310, 247, 5185, 6021, 11786, 275, 1029, 13559, 2308, 13, 342, 7108, 387, 2406, 6021, 2308, 1907, 28249, 2169, 6658, 448, 11201, 3017, 685, 616, 2169, 14, 20666, 21421, 15775, 709, 18, 2947, 709, 1036, 1184, 187, 187, 9379, 12343, 8996, 310, 2169, 2190, 2406, 30270, 2390, 285, 2190, 26769, 13, 2448, 16869, 16, 2422, 11304, 427, 3993, 13, 285, 3032, 4029, 982, 15775, 709, 18, 2947, 709, 1036, 2947, 709, 1731, 1184, 8404, 966, 27935, 285, 15066, 43586, 275, 1982, 13833, 4142, 452, 32178, 323, 253, 2469, 577, 8007, 15775, 709, 18, 2947, 709, 1731, 1184, 2726, 13833, 285, 8401, 8996, 11440, 281, 6054, 275, 253, 1986, 2077, 285, 10470, 285, 3520, 275, 12135, 2308, 1146, 4942, 1029, 2190, 2067, 15066, 16, 678, 9335, 285, 10621, 46193, 5576, 2390, 13, 2007, 34044, 275, 1982, 13440, 2728, 7891, 403, 417, 247, 1677, 15775, 709, 18, 2947, 709, 1036, 2947, 709, 1731, 1184, 8079, 13, 342, 8996, 273, 1142, 6722, 2728, 2495, 2616, 327, 253, 6054, 275, 1142, 4243, 273, 253, 1533, 13, 253, 4156, 7977, 273, 13440, 2728, 285, 643, 1327, 14, 11713, 35232, 6578, 824, 347, 2923, 285, 8401, 310, 3264, 281, 2572, 2007, 13, 3782, 275, 1698, 14, 285, 4766, 14, 20666, 4343, 13, 835, 689, 5096, 6, 273, 512, 30243, 8923, 2826, 15775, 709, 23, 2947, 709, 24, 2947, 709, 1630, 2947, 709, 1619, 1184, 187, 187, 510, 11935, 6127, 275, 30243, 7891, 2011, 1060, 403, 5185, 342, 1110, 2540, 3786, 323, 253, 1986, 2077, 13, 835, 30270, 43586, 313, 249, 2426, 273, 4103, 25930, 10, 2559, 689, 673, 1014, 347, 4583, 30243, 7891, 4142, 13072, 22293, 15775, 709, 883, 1184, 329, 2045, 27218, 3338, 1783, 1754, 327, 253, 13842, 14, 14643, 956, 14, 484, 2692, 6832, 13737, 30270, 27935, 275, 30243, 7891, 13, 342, 1821, 285, 2255, 342, 1698, 2308, 273, 4730, 285, 2021, 6021, 1907, 4791, 14, 3571, 6, 2169, 10904, 10502, 273, 30243, 7891, 685, 1110, 342, 1029, 4730, 285, 6021, 2308, 13, 247, 4560, 13333, 342, 776, 1263, 15775, 709, 1012, 1184, 5220, 5185, 342, 776, 1263, 13, 253, 2045, 27218, 3338, 1263, 1119, 4567, 14, 1857, 6, 2406, 30243, 7891, 10502, 275, 28787, 2255, 285, 1821, 685, 616, 1327, 14, 8389, 19239, 3168, 21421, 13, 1014, 846, 19427, 323, 30270, 285, 18825, 5319, 15775, 709, 1012, 1184, 38078, 30270, 43586, 275, 30243, 7891, 2011, 1060, 403, 5185, 342, 1110, 2540, 323, 2067, 5284, 4343, 3738, 253, 9777, 273, 43135, 43586, 275, 253, 1982, 14280, 281, 320, 3687, 685, 326, 323, 690, 4343, 275, 10586, 3060, 15775, 709, 1717, 17548, 709, 1610, 1184, 6975, 253, 1986, 2077, 13, 2675, 966, 27935, 275, 13440, 2728, 285, 23523, 2798, 2728, 7891, 275, 253, 1986, 11491, 285, 643, 5284, 4343, 2559, 347, 7891, 4142, 13072, 625, 9086, 323, 1110, 275, 2406, 2675, 966, 2390, 390, 625, 25979, 3672, 15775, 709, 1717, 17548, 709, 1610, 1184, 187, 187, 22807, 285, 11841, 4775, 3173, 35663, 1712, 1704, 18, 14, 22, 94, 187, 4578, 6428, 187, 187, 10252, 86, 960, 275, 30243, 7891, 4142, 323, 512, 30270, 285, 15066, 16, 678, 9335, 2390, 275, 253, 1982, 452, 9945, 9619, 281, 15988, 275, 1495, 36082, 689, 673, 285, 1364, 320, 2326, 347, 247, 2201, 1345, 1786, 19797, 15, 1723, 13, 253, 5675, 30270, 285, 15066, 43586, 275, 30243, 7891, 3464, 247, 2201, 1345, 3646, 4468, 15, 4923, 13440, 6578, 403, 253, 4283, 2847, 273, 2471, 285, 2395, 323, 4829, 581, 14, 19016, 273, 512, 1982, 8923, 13, 841, 50050, 25930, 275, 30243, 7891, 8162, 10260, 281, 4583, 2308, 273, 1786, 285, 7891, 25930, 275, 253, 1986, 2077, 15775, 709, 18, 2947, 709, 21, 2947, 709, 740, 2947, 709, 883, 1184, 2053, 43586, 275, 7891, 4887, 6832, 285, 11440, 18388, 275, 30243, 12212, 285, 1453, 6031, 2439, 2710, 3072, 22105, 15, 23230, 11370, 275, 2675, 285, 14613, 2495, 2616, 310, 4931, 271, 1774, 15979, 2803, 323, 253, 1986, 2077, 8, 43257, 6306, 275, 30243, 7891, 4103, 281, 1142, 643, 17273, 323, 19190, 15859, 318, 285, 9753, 313, 32658, 3717, 10, 4343, 15775, 709, 1237, 17548, 709, 1706, 1184, 1198, 1650, 13, 6144, 13, 1986, 11491, 13, 6976, 13, 6176, 13, 16842, 13, 20341, 13, 22783, 13, 285, 18908, 452, 3012, 2406, 7891, 4142, 432, 23523, 2798, 2728, 13, 285, 253, 4142, 323, 3684, 9733, 13, 4047, 13, 285, 6181, 403, 3925, 14, 1967, 6, 2406, 685, 1110, 323, 253, 1986, 2077, 15775, 709, 1706, 1184, 187, 187, 6175, 2544, 275, 253, 2675, 47149, 273, 14613, 2495, 2616, 824, 347, 10470, 13, 6196, 13, 3520, 275, 12135, 13, 285, 7665, 897, 778, 452, 644, 8127, 5506, 323, 11935, 2675, 25930, 275, 30243, 7891, 13, 253, 25930, 275, 14898, 2616, 403, 3746, 8127, 3413, 407, 6944, 2675, 285, 5054, 2616, 15775, 709, 883, 2947, 709, 1047, 2947, 709, 1010, 2947, 709, 938, 2947, 709, 1671, 1184, 29475, 267, 285, 1786, 1557, 12214, 651, 2779, 320, 1679, 3576, 1293, 15974, 253, 4067, 38058, 16, 21637, 285, 5054, 5621, 326, 1918, 6054, 281, 25930, 275, 14613, 2495, 2616, 275, 253, 806, 1659, 15775, 709, 883, 2947, 709, 1047, 2947, 709, 1229, 2947, 709, 1671, 1184, 329, 3862, 2282, 273, 3646, 2250, 342, 247, 2590, 15075, 327, 253, 14200, 2675, 29647, 310, 13, 3103, 13, 3058, 281, 18915, 253, 1895, 273, 5675, 25930, 275, 30243, 7891, 15775, 709, 883, 2947, 709, 1229, 2947, 709, 1671, 1184, 4775, 285, 2675, 3646, 12214, 824, 347, 5520, 2289, 281, 1786, 3238, 285, 23082, 275, 25930, 275, 4730, 13, 14192, 13, 20549, 13, 17238, 13, 285, 8039, 403, 5667, 323, 46710, 1048, 14, 3945, 1786, 25930, 275, 30243, 7891, 875, 30270, 285, 15066, 2390, 275, 253, 1986, 2077, 15775, 709, 23, 2947, 709, 883, 2947, 709, 1047, 2947, 709, 1229, 2947, 709, 1671, 1184, 187, 187, 5146, 10030, 15551, 1131, 187, 187, 15383, 16, 11300, 43586, 275, 7891, 432, 13440, 2728, 313, 783, 4283, 2847, 273, 2471, 275, 253, 1982, 323, 253, 2469, 4314, 8007, 10, 9461, 12724, 701, 2721, 257, 16648, 285, 4072, 15, 25216, 2308, 273, 2170, 14, 285, 2060, 14, 5251, 30270, 1899, 497, 2330, 342, 9619, 2169, 4142, 273, 13440, 14, 69, 42294, 7891, 2190, 1982, 1821, 285, 2255, 1309, 253, 1263, 2180, 15, 23954, 30270, 25930, 275, 13440, 14, 69, 42294, 7891, 2559, 12724, 875, 16648, 285, 4332, 323, 253, 2264, 1982, 3072, 13, 19991, 13, 285, 26769, 347, 2169, 30270, 2390, 7407, 7938, 7891 ]
.54-1.21 304.79 27.93 1.03 0.82-1.24 5.15 Craftsmen and kindred 343.38 62.17 0.93 0.54-1.32 315.02 30.67 1.07 0.84-1.30 8.26 Operatives, except transport 425.18 79.55 1.15 1.66-1.65 368.08 23.05 1.25 1.05-1.44 13.43 Transport equipment operatives 757.06 112.86 2.57 1.77-3.36 Laborers 551.14 73.65 1.50 0.99-2.01 298.11 47.83 1.01 0.68-1.34 45.91 Discussion {#sec1-4} ========== Cardiovascular disease mortality rates have decreased substantially for all socioeconomic and racial/ethnic groups in the United States. Despite the impressive overall decline in mortality, socioeconomic and racial disparities in CVD mortality have remained marked and increased over time, as relative inequalities in mortality widened consistently between 1969 and 2013. During 1969-2013, whites and those in more affluent groups experienced faster declines in CVD mortality than blacks and those in more deprived groups respectively, which contributed to the widening gap in CVD mortality. Absolute inequalities in CVD mortality, as measured by mortality rate differences, also widened between black and white populations and across deprivation groups during the past three decades. These marked and growing social inequalities in CVD mortality runs counter to the goals of the national health initiative that calls for further reductions or elimination of health inequalities in the United States, including those in cardiovascular disease, by 2020.\[[@ref8]\] Area-based socioeconomic differences in CVD mortality reported here are consistent with those at the individual level. Cardiovascular disease mortality rates in 1979-1989 and 1990-1998 by individual-level socioeconomic and demographic characteristics presented herein should serve as the baseline data for comparison with more recent mortality follow-up data in the NLMS and for comparison with international patterns.\[[@ref17]\] Socioeconomic and racial/ethnic disparities in CVD mortality reflect inequalities in the social environment (e.g., material living conditions, social support, and stress), behavioral risk factors such as smoking, obesity, physical inactivity, disease prevalence, and healthcare access and treatment.\[[@ref6],[@ref7],[@ref11],[@ref14]\] In the United States, racial/ethnic minorities such as blacks, American Indians/Alaska Natives, and Hispanics are greatly disadvantaged in socioeconomic attainment compared to whites. They have significantly lower education and income levels and higher rates of poverty, unemployment, and lack of health insurance than whites.\[[@ref1],[@ref23]-[@ref25]\] During the past 4 decades, poverty rates for blacks and Hispanics have been 2-3 times higher than the rate for whites, and the unemployment rate for backs has consistently been twice that for whites.\[[@ref1],[@ref23],[@ref24]\] The substantial white-black gap in median family income has persisted, and absolute racial differences in income have widened over time.\[[@ref24],[@ref25]\] In general, ethnic minorities and individuals with lower SES or in more deprived areas of the United States have reduced access to health care and are more likely to forego or delay preventive or needed medical care than their more advantaged counterparts.\[[@ref1],[@ref11],[@ref20]\] With reduced access to preventive care and early detection services, individuals in disadvantaged minority groups are more likely to be diagnosed with advanced disease and have lower survival rates even after controlling for socioeconomic characteristics.\[[@ref20]\] Racial/ethnic and socioeconomic patterns in risk factors such as smoking, hypertension, and serum cholesterol are generally consistent with those in CVD mortality. Smoking prevalence is higher in American Indians/Alaska Natives, whites, and blacks than Asians.\[[@ref1],[@ref16]\] Smoking prevalence is also substantially higher in lower SES groups or more deprived areas, and has fallen much more rapidly in higher SES groups than in more disadvantaged groups.\[[@ref1],[@ref16]\] In 2012, the prevalence of hypertension was 38% higher in blacks than whites, whereas those with low education and family income levels had an approximately 50% higher prevalence of hypertension than their low-SES counterparts.\[[@ref16]\] There is a consistent income gradient in high cholesterol levels, with Americans at lower income levels having moderately higher serum cholesterols than their higher-income counterparts.\[[@ref1],[@ref16]\] Obesity prevalence is higher among lower socioeconomic groups and among blacks, American Indians/Alaska Natives, and Hispanics.\[[@ref1],[@ref16],[@ref26]\] Social class gradients and racial disparities in US obesity rates have persisted for the past 4 decades.\[[@ref1],[@ref26]\] With obesity and diabetes prevalence continuing to rise in the United States and smoking and physical inactivity levels being relatively high among several racial/ethnic and sociodemographic groups, further declines in US cardiovascular disease mortality are not a given.\[[@ref1],[@ref16],[@ref26]\] Indeed, with prevalence of many chronic disease risk factors on the rise in many parts of the world, the global burden of cardiovascular disease and other non-communicable diseases such as cancer and diabetes is expected to increase further, particularly in low- and middle-income countries, where over 80% of all CVD deaths occur.\[[@ref6],[@ref7],[@ref27],[@ref28]\] The temporal patterns in CVD mortality shown here are consistent with those observed previously for the United States, where socioeconomic disparities (in terms of relative inequalities) increased over time even as overall CVD mortality rates declined markedly.\[[@ref11]\] A previous NLMS analysis based on the 1979-1989 follow-up showed substantial inverse socioeconomic gradients in CVD mortality, with men and women with low levels of education and family income having 35-63% higher adjusted risks of CVD mortality than those with high education and income levels, a finding compatible with our study.\[[@ref13]\] Also consistent with our study, the previous NLMS study found 32-45% lower CVD mortality risks in Hispanic women and men than their non-Hispanic white counterparts, even after adjusting for socioeconomic and demographic characteristics.\[[@ref13]\] Increasing socioeconomic disparities in CVD mortality shown here are consistent with those observed for several European countries although the magnitude of SES disparities in the US tends to be greater than that for some countries in Southern Europe.\[[@ref29]-[@ref33]\] Like the United States, social class gradients in cardiovascular disease and ischemic heart disease mortality in the United Kingdom and other European countries increased as mortality rates declined more rapidly for those in lower social class groups or more deprived areas.\[[@ref29]-[@ref33]\] Conclusions and Global Health Implications {#sec1-5} ========================================== Reductions in CVD mortality rates for all socioeconomic and racial/ethnic groups in the US have contributed substantially to gains in life expectancy over time and must be seen as a major public health achievement. However, the growing socioeconomic and racial disparities in CVD mortality remain a major public policy concern. Because cardiovascular diseases are the leading cause of death and account for nearly one-third of all US deaths, these widening inequalities in CVD mortality contribute greatly to overall levels of health and mortality inequalities in the United States.\[[@ref1],[@ref4],[@ref10],[@ref11]\] These disparities in mortality reflect substantial and continuing gaps in CVD prevention and control efforts across various population subgroups. Higher inequality in social and behavioral risk factors is perhaps an important contributing factor for the United States' unfavorable standing in CVD mortality relative to many other Organization for Economic Cooperation and Development (OECD) countries.\[[@ref32]-[@ref34]\] For example, Canada, United Kingdom, Australia, Germany, Sweden, Norway, Denmark, and Switzerland have significantly lower mortality rates from ischemic heart disease, and the rates for South Korea, Japan, and France are 60-70% lower than those for the United States.\[[@ref34]\] While changes in the social patterning of behavioral risk factors such as smoking, diet, physical inactivity, and alcohol use may have been largely responsible for temporal social inequalities in CVD mortality, the inequalities in lifestyle factors are themselves largely determined by underlying social and economic factors.\[[@ref11],[@ref14],[@ref15],[@ref20],[@ref35]\] Behavioral and health care interventions would likely be less effective without addressing the larger societal/social and economic forces that give rise to inequalities in behavioral risk factors in the first place.\[[@ref11],[@ref14],[@ref30],[@ref35]\] A broad course of policy action with a clear emphasis on the wider social determinants is, therefore, needed to tackle the problem of growing inequalities in CVD mortality.\[[@ref11],[@ref30],[@ref35]\] Health and social policy interventions such as improved access to health services and reductions in inequalities in education, poverty, unemployment, occupation, and housing are essential for tackling long-term health inequalities in CVD mortality between socioeconomic and racial groups in the United States.\[[@ref6],[@ref11],[@ref14],[@ref30],[@ref35]\] ###### Key Messages Black/white disparities in mortality from cardiovascular disease (the leading cause of death in the US for the past eight decades) rose consistently betzeen 1969 and 2013.Lower levels of area- and individual-level socioeconomic position were associated with substantially higher rates of cardiovascular-disease mortality among US men and women during the study period.Area socioeconomic inequalities in cardiovascular-disease mortality increased consistently between 1969 and 2011 for the total US population, whites, and blacks as higher socioeconomic groups experienced faster mortality
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{{\mathbb Z}}/2Z$). Similarly the collection of above $g^*$’s defines a global graded ring homomorphism $$g^*: {{\mathcal B}}^\bullet(Y;R)\to {{\mathcal B}}^\bullet(X;R) \ .$$ We can summarize the above achievements as follows: $$X \ \Rightarrow {{\mathcal B}}^\bullet(X;R)$$ $$g:X\to Y \ \Rightarrow g^*: {{\mathcal B}}^\bullet(Y;R)\to {{\mathcal B}}^\bullet(X;R)$$ [*define a contravariant functor from the category of compact boundaryless (possibly oriented) smooth manifolds and smooth maps to the category of graded rings and graded ring homomorphisms.*]{} [A graded ring verifying the [*non*]{} commutative rule (3) in Proposition \[cup\] is sometimes called a “commutative” graded ring.]{} \[ring-point\][A particular case of the above constructions is when $X$ is reduced to one point. In this case the product $${{\mathcal B}}^r(R) \times {{\mathcal B}}^s(R) \to {{\mathcal B}}^{r+s}(R)$$ for every couple of indices $r,s\leq 0$ is just defined by the product of representatives $$[M]\sqcup [N] = [M\times N] \ .$$]{} \[non-compact\] (Non compact $X$) [Referring to the setting of the tranversality theorems of Section \[map-transv\], we can extend the range of cobordism functors and product to the category of boundaryless possibly non compact manifolds $X$ but which can be embedded anyway in some ${{\mathbb R}}^k$ being also a closed subset, and smooth [*proper*]{} maps between these manifolds.]{} Duality, intersection forms {#intersection-form} --------------------------- Assume that $X$ is connected (possibly oriented), $\dim (X)=n$. Then $${{\mathcal B}}^n(X;R)\sim {{\mathcal B}}_0(X;R) \sim R \ .$$ If $R={{\mathbb Z}}/2{{\mathbb Z}}$, we have a generator $\beta_X$ of ${{\mathcal B}}^n(X;{{\mathbb Z}}/2{{\mathbb Z}})$ represented as $\beta_X=[x,i]$ where $x \in X$ and $i$ is the inclusion (it does not depend on the choice of $x$ because $X$ is path connected). If $R={{\mathbb Z}}$ we have two generators of the form $[\pm x, i]$. As usual we encode the point sign by associating to $+x$ the orientation on $T_xX$ carried by the global orientation of $X$ and this selects again one generator $\beta_X$. By this choice of generators we have fixed in both cases an identification of ${{\mathcal B}}^n(X;R)$ with $R$. For every $r,s$, set $p=n-r$, $q=n-s$. Let $r,s$ be such that $r+s=n$ (hence also $p+q= n$, $p=s$, $q=r$). Then $$\sqcup : {{\mathcal B}}^r(X;R)\times {{\mathcal B}}^s(X;R) \to R \ .$$ Note in particular that $$d(\alpha_X)\sqcup \beta_X=1$$ where $\alpha_X=[X,{\rm id}_X]\in {{\mathcal B}}_n(X;R)$ is the bordism fundamental class of $X$ and $d:{{\mathcal B}}_n(X;R)\to {{\mathcal B}}^0(X;R)$ is the tautological isomorphism. By using the tautological isomorphisms, all this can be lifted to a bilinear map $$\bullet: {{\mathcal B}}_{p}(X;R)\times {{\mathcal B}}_{q}(X;R)\to R$$ or to a bilinear pairing $$\sqcap: {{\mathcal B}}^r(X;R)\times {{\mathcal B}}_{q}(X;R)\to R \ .$$ This last induces a linear map ($q=r$) $$\phi^r: {{\mathcal B}}^r(X;R)\to {\rm Hom}({{\mathcal B}}_{r}(X;R),R), \ \gamma\to \phi_\gamma, \ \phi_\gamma(\sigma)=\gamma \sqcap \sigma \ .$$ Recall that by applying the Hom functors we have a basic way to convert the covariant bordism funtors into cotravariant ones $$X \ \Rightarrow {\rm Hom}({{\mathcal B}}_m(X;R), R)$$ $$g:X\to Y \ \Rightarrow g^t_*: {\rm Hom}({{\mathcal B}}_m(Y;R),R)\to {\rm Hom}({{\mathcal B}}_m(X;R),R)$$ $g^t_*(\gamma)= \gamma \circ g_*$. The homomorphisms $\phi^r$, $g^t_*$ and $g^*$ are compatible; in a slogan: “$ \phi^r \circ g^* = g^t_* \circ \phi^r$” The map $\phi^r$ is in general not injective nor surjective. A reason is the possible existence of non trivial submodules of ${{\mathcal B}}_*(X;R)$ isomorphic to ${{\mathcal B}}_*={{\mathcal B}}_*(\{x_0\};R)$. The image via the tautological isomorphism of such submodule in ${{\mathcal B}}^r(X;R)$ is contained in the kernel of $\phi^r$. If $R={{\mathbb Z}}/2{{\mathbb Z}}$, so that ${{\mathcal B}}_{r}$ can be realized as a direct addend of ${{\mathcal B}}_{r}(X;{{\mathbb Z}}/2{{\mathbb Z}})$, then any functional $\gamma$ which holds $1$ on ${{\mathcal B}}_{r}$ and such that ${{\mathcal B}}_{r}(X;{{\mathbb Z}}/2{{\mathbb Z}})= {{\mathcal B}}_{r}\oplus \ker \gamma$ does not belong to the image of $\phi^r$. If $R={{\mathbb Z}}$, then the [*torsion submodule*]{} of ${{\mathcal B}}^r(X;{{\mathbb Z}})$ is contained in the kernel of $\phi^r$. For every $r$ we set $${{\mathcal H}}^r(X;R):= {{\mathcal B}}^r(X;R)/\ker (\phi^r)$$ and extending the usual reindexing set $${{\mathcal H}}_{n-r}(X;R):= {{\mathcal H}}^r(X;R)$$ where in this last equality only the $R$-module structure is considered, forgetting the multiplicative structure. Then the above map $\phi^r$ induces an injective $R$-linear map $$\hat \phi^r: {{\mathcal H}}^r(X;R)\to {\rm Hom}({{\mathcal H}}_{r}(X;R),R) \ .$$ If $X$ is connected (possibly oriented), then $${{\mathcal H}}^0(X;R) \sim R$$ and is generated by the fundamental class. The map $\sqcap$ can be formally generalized by composing $\sqcup$ with the tautological isomorphisms $$\sqcap : {{\mathcal B}}^r(X;R)\times {{\mathcal B}}_q(X;R) \to {{\mathcal B}}_{2n-(r+q)}(X;R) \ .$$ In particular $$\sqcap: {{\mathcal B}}^r(X;R)\times {{\mathcal B}}_n(X;R)\to {{\mathcal B}}_{n-r}(X;R)$$ and it is a consequence of the definitions that for every $\sigma \in {{\mathcal B}}^r(X;R)$ $$\sigma \sqcap \alpha_X = D(\sigma) \ .$$ If $\dim (X)=2m$ then we can consider $$\sqcup: {{\mathcal B}}^m(X;R)\times {{\mathcal B}}^m(X;R)\to R$$ or equivalently $$\bullet : {{\mathcal B}}_m(X;R)\times {{\mathcal B}}_m(X;R)\to R$$ this second is also called the [*$R$-bordism intersection form of $X$*]{}. Note that these forms are symmetric on ${{\mathbb Z}}/2{{\mathbb Z}}$, while on ${{\mathbb Z}}$ they are symmetric (resp. antisymmetric) if $m$ is even ($m$ is odd). The kernel of $\phi^r$ coincides in this case with the [*radical*]{} of the form, hence the induced form (also called “intersection form") $$\sqcup: {{\mathcal H}}^m(X;R) \times {{\mathcal H}}^m(X;R) \to R$$ determines an inclusion of ${{\mathcal H}}^m(X;R)$ as a submodule of its dual module $$\hat \phi^m: {{\mathcal H}}^m(X;R)\to {\rm Hom}({{\mathcal H}}_m(X;R),R) \ .$$ Cobordism theory for compact manifolds with boundary {#relative-cb} ---------------------------------------------------- First let us strengthen the notion of map between pairs of spaces $$h:(X,A)\to (Y,B) \ ;$$ it is a [*strict*]{} pair map if (as usual) $h(A)\subset B$ and furthermore $h(X\setminus A)\subset Y\setminus B$. We consider the category of compact smooth (possibly oriented) manifolds with (possibly empty) boundary $(X,\partial X)$ and smooth strict pair maps $$h: (X,\partial X)\to (Y, \partial Y)
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humiliated, shamed, or degraded. Why should they? It would be absurd that they should. They are beautiful, they are desired, they are prized. They are a lovely and precious ingredient in Gorean civilization. Are they not special? Were they not, would men bid upon them and buy them with such eagerness? A new slave, of course, might feel, at least at the beginning, what free women would like them to feel all the time, embarrassment, burning shame, acute mortification, and such. Is there not a collar on their neck, which they cannot remove? Are they in slave garb not much bared, even brazenly exhibited? Must they not now kneel, even to those who might formerly have been equals and peers? Must they not now obey instantly and unquestioningly? Are they not now owned? Are they not now properties? May they not now be bought and sold? Are they not now, too, mere animals, livestock? But these feelings tend to pass. The collar soon comes to be viewed not as an emblem of degradation but as a badge of quality, a symbol of female excellence, which, to be sure, she cannot remove, a testimonial to her desirability, a sign that she has been found of interest to men, that she is a woman of the sort men want. And when she becomes more a slave she comes to understand that slave garb is not degrading, but enhancing. She discovers that her beauty, unlike when she was a free woman, is nothing to be ashamed of, but is rather something in which to rejoice, something in which to take pleasure and pride. It does not dismay her vanity to learn that she is attractive, and beautiful, even "slave beautiful." Would it yours? And she is, of course, well aware that where her charms are concerned slave garb will keep few secrets. Accordingly, she soon comes to prize her tunics, camisks, ta-teeras, and such. She knows how wonderfully beautiful and exciting she is in them. In them, scantily clad, she is stunning, a vision of delight, delicious, a viand, a repast, a banquet, for masters; does her soft glance not invite men to her subjugation; does her walk not suggest she would leap helplessly, uncontrollably, under a male caress; in her eyes can they not detect a mute plea, expressive of the need and readiness of a slave? Best she should quickly hurry home to her master! Begone, girl! Do not torture us! Hasten to your own chains! You should see her walk before men! You see, too, slave garb augments her attractions and excitements in dimensions other than the purely aesthetic. For example, in it she is identified as a slave, a property, something which one might own. Do you think that this does not add to her interest? And, of course, she soon, as a female, learns the pleasures and proprieties of pleasing and serving, of kneeling before her master, of hastening to obey, and so on. Let her beware, of course, the switches of free women, who will hate her. Is a slave happy? In theory, this does not matter. Who cares for the feelings of a slave? But obviously this depends on many things. I certainly was not happy in the laundry, in the house of Mirus. It seems to me improbable that the girls in the mills would be happy, or very much so. I doubt that the naked slaves in the tiny, crooked shafts of silver mines, carrying water to miners, have an easy life, and so on. Too, one supposes the girls on the great farms, struggling with plows, hoeing shackled, chained in seeding and harvesting coffles, kenneled at night, would just as soon be city slaves, and so on. Most slaves, however, certainly those with private masters, are happy in their collars, even radiantly so, even pot girls, and kettle-and-mat girls, and take great pleasure in pleasing and serving their masters. They are given the domination and mastering which a woman requires, and under which she thrives and blossoms. Gor celebrates nature; she does not deny her. The slave lives in a world of intimacy and emotional richness. She belongs to her master. She finds herself fulfilled in the collar. To be sure, she knows she is only a slave. But this, too, in its way, as she wants to be a slave, gives her great pleasure. Let us take a simple example, in this discussion of supposed humiliation, and such, which may prove to be illuminating. Suppose two women, one a free woman, the other a slave, both stripped. Both are commanded to belly, and lick and kiss a man's feet. The free woman, one supposes, will experience humiliation, shame, and such, and, in performing this simple, lovely act, may feel degraded, and so on. It is not unusual, of course, that the free woman, as she is a woman, will feel there is an appropriateness in her performing this act, and may actually, in a way, find her sensations, which she would pretend to deplore, delicious. In any event, she is doubtless on her way to the collar. Now a slave, performing the same act, and doubtless with much greater skill, is likely to feel grateful and loving. Her master, after all, is permitting her to perform this appropriate, intimate and lovely act. She feels very slavelike in doing this, but this pleases her, as she is a slave. She loves her sense of lowliness, her sense of being her master's slave. She wishes to do this, as it is fitting for her, and it permits her to manifest and express her tenderness and submission. Similarly, consider the kissing of the whip. Imagine the feelings of a free woman forced to kiss the whip, perhaps finding her feelings surprisingly and troublesomely delicious, and those of the slave, grateful to be permitted an opportunity to perform this beautiful symbolic act, of submission. And so Mirus, in having had Ellen called to the ba-ta circle, had intended not only to shame her, having her dance as a slave, but had expected her to dance badly, thus shaming herself as a woman, as well, and had then intended, in consequence of her presumed inept, blundering debacle, that she would be put under the whip, to suffer a lashing commensurate with the inadequacies of her performance. But the cruel plan of Mirus had failed of its realization! She had, it seems, done well! How frustrated, how furious, he must have been. But, too, she suspected that he had been fascinated, intrigued, by her performance, that of an attractive slave, one of whom, wisely or not, he had once ridded himself. And now, perhaps regretting his earlier haste or indiscretion, he had followed her, and with the intention, it seemed, not of killing her, as his companions so clearly seemed to have in mind, but rather of bringing her again within the ambit of his mastery. "But it seems," said the spokesman, "that things did not turn out as you expected." "That is true," mused Mirus. "I had not expected her to do so well." "She saw too much, she knows too much," said the spokesman. "You should never have let her go." "I did not "let her go,"" said Mirus. "It was my intention, after forcing her to undergo the indignity and shame of a public sale, to buy her back." "But it did not work out that way." "No." "In pursuing your trivial, personal vendetta with that meaningless little collar slut," said the spokesman, "you have jeopardized our plans." "I had no way of knowing," said Mirus. "You were going to buy her back!" "Certainly." "Ah, yes, pretty little "117," and she received bids that shook the market." "I had no idea I could be outbid," said Mirus, angrily. "Yes, you had to publicly buy her, openly, before an entire market, that she would know herself a purchased slave, yours completely, owned, and for no more, you thought, than a handful of coins." "How could I know that others could bid higher?" asked Mirus, angrily. Ellen, on her knees near the wagon, sick, put her head down. It is all my fault, she thought. All my fault! Can he care for me, Ellen asked herself. Clearly, I am sure, he wants me. Slaves are familiar, of course, with being wanted. They have little doubt about such things. Can they not see that in the blazing eyes of men? They are sought, captured, stolen, netted, roped, chained, sold, bought, owned. Is their neck's encirclement not sufficient evidence as to their being wanted? This is very different, of course, from being cared for, or admired, or appreciated, or loved, or such. A slave may often find herself, sometimes to her dismay or terror, the focus of an uncompromised, ferocious lust, a desire so powerful that it can be satisfied by nothing less than the owning of her, the tearing away of her clothing and the hurling of her to one's feet, where she is collared. This is how a slave is often
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continued to climb, so as his carbon dioxide reached a level of over a hundred at – at – 2051. And I think really, the key to this is that – is that the difficulty in ventilation was already one of the key factors that was aggravating his metabolic acidosis because as carbon dioxide climbed, that led to an increase in his pulmonary-vascular resistance, which is the – basically the impedance against which the right ventricle has to eject. That in turn led to a reduction in right-ventricular function, right-ventricular performance, which decreases pulmonary blood flow. And of course, pulmonary blood flow is exactly the same as your cardiac output, so ultimately that right-ventricular dysfunction led to the cardio-vascular collapse that occurred around 2130.” It is then necessary to return to the oral evidence of Dr Barratt, upon which the trial judge placed significant weight. Dr Barratt was cross-examined about the conversation he had with Dr Sparks over the telephone. His evidence was that the conversation took place at about 9.30pm, but it was accepted that the phone call occurred just prior to 9pm. He agreed that the discussion had included the possibility of cardiac compression generating the potential for hypotension with the consequence that critical organs might not be adequately perfused. The discussion had included Dr Sparks’ concern about high arterial carbon dioxide and the fact that he had checked that the patient was properly ventilated “but he still could not explain the problem.” The cross-examination continued:[41] “Q. So your response was that probably, or maybe, a pulmonary artery was compressed along with possible cardiac compressions, it means his lung was being ventilated but not perfused? A. That is exactly correct. Q. What is ventilated but not perfused mean? A. It means that there is inability to eliminate carbon dioxide from the lung because there’s no blood going through the alveolus and all this air is just coming into the lung and can’t take the carbon dioxide out so the carbon dioxide is going to build up. Q. And the consequence of that is what? A. A carbon dioxide level of 65 is not a problem physiologically but for that to happen, you have to be pressing on a pulmonary artery in such a significant way that it’s going to impede [cardiac] output and organ perfusion. Q. And the consequence of that is what? ... If uncorrected? A. Critical end–organ ischemia. ... Q. And the consequence of that in a longer term sense if these organs are damaged was what? A. Well, a low [cardiac] output state could damage the brain, the spinal cord, the kidneys, or the liver, for instance, potentially. ... Q. Doctor Sparks told you that the various metabolic indicators were critical? A. Yes, yes. Q. Despite, apparently, adequate blood pressure and blood oxygen levels. That was one of his dilemmas, wasn’t it? A. Yes, yep. Q. Then in those circumstances, it really wasn’t appropriate, was it, to look at the blood pressure and oxygen levels alone when making a decision whether to persist or abandon surgery? A. I agree with that statement.” The trial judge’s conclusion, based on that evidence was expressed in the following terms:[42] “It is important not to lose sight of the fact that Dr Sparks and Dr Gray were confronted with what was patently a distressing and fraught intraoperative emergency. It is difficult to over-emphasise just how awful it must have been at that time for all concerned. It is clear that Dr Sparks had attempted all of the anaesthetic manoeuvres in his armoury to correct the problem without apparent success. Criticism of these doctors in those circumstances may seem harsh. However, it is not in question that stopping the surgery when no obvious answer to the problems confronting the doctors was presenting itself would have avoided the damage. We know with hindsight that postural adjustment from prone to supine produced immediate resolution of these problems. That was something which in my opinion Dr Sparks and Dr Gray should have foreseen and acted upon. Failure to do so amounted to a want of reasonable care. It was in my view not appropriate to take the risk that something that could not be explained would or might somehow spontaneously resolve or improve. It is no answer to insist that the surgery was lifesaving in circumstances where Mr Hobson’s respiratory difficulties at or after 20.30 had deteriorated below his pre-operative condition in ICU.” Finally, the judge considered that the absence of spinal cord monitoring “heightened the need to act conservatively and to proceed expeditiously. It told against the appropriateness of taking an expectant approach when the solution to Mr Hobson’s difficulties had not emerged or was not understood.” So far as Dr Sparks is concerned, and without reference to s 5O of the Civil Liability Act, in my view that conclusion was sound. Application of s 5O (a) approach adopted at trial For reasons set out above, the proper course in a case where s 5O has been pleaded and has been the subject of evidence is to determine first the standard of care to be applied, before assessing the alleged negligence against that standard. The trial judge did not take that approach but rather, in accordance with what was understood to be the appropriate course at the time, considered s 5O as a defence to be addressed after findings had been made on the plaintiff’s case. That indeed was the manner in which counsel for Dr Sparks dealt with the matter in written submissions at trial. Counsel for Dr Sparks asserted that where there is evidence to demonstrate that the defendant acted in a manner which was widely accepted by peer professional opinion as competent professional practice, that opinion determined the standard of care and the expert evidence was conclusive.[43] Counsel further asserted that the approach adopted by this Court in McKenna should not be followed as it was inconsistent with the reasoning in Dobler. However, if McKenna were to be followed, it was submitted that the conduct of the defendant in exercising judgment as to the time for cessation of the operation constituted a “practice”. The submissions simply relied upon the evidence of Dr Forrest as establishing the defence. In oral submissions, there was reference to the reasoning in McKenna, but no further attempt to grapple with the evidential requirements of s 5O. In these circumstances, it is unsurprising that the trial judge dealt with the matter by way of a defence, noting the paucity of evidence in support of it. Having already rejected the views of the defendants’ doctors as to whether the conduct of the practitioners was negligent, the judge considered that the defence under s 5O had also effectively been rejected.[44] It is correct to say that the reasoning of the trial judge did not address the submission that Dr Forrest’s evidence could not be rejected unless it was shown to be irrational. Nor did it expressly address the proposition that Dr Forrest’s opinion was “conclusive” as to the relevant standard of care. Grounds 1 and 2 in Dr Sparks’ notice of appeal rely on these matters as demonstrating error. On the appeal, Dr Sparks’ written submissions identified the evidence relied on in support of the s 5O test as that of Dr Forrest (called in Dr Sparks’ case) and the evidence of Dr Manasiev, called for Dr Gray but who expressed opinions as to the conduct of both Dr Gray and Dr Sparks. It was submitted that the opinions were unchallenged. As Simpson JA explains, the trial did not proceed smoothly. The pleadings left much to be desired as to detail; parties were joined and then removed; the plaintiff’s case was recast on more than one occasion, and the evidence of the experts was, inevitably in these circumstances, not always clearly directed to the issues as they finally emerged. The task of the trial judge in these circumstances was fraught with difficulties. Nevertheless, it is apparent that s 5O was relied upon by Dr Sparks and was not correctly disposed of at trial. It is therefore necessary for this Court to address the evidence. Despite the conclusion reached above that the proper approach where s 5O is relied upon is to consider all the evidence in order to reach satisfaction as to the relevant standard of competent professional practice, to adopt such a course on this appeal would be impractical for two reasons, both of which operated at the trial. First, one cannot seek to identify a standard of competent professional practice in the abstract; the standard must relate to the specific ways in which negligence is alleged. Because the pleadings of the plaintiff bore limited resemblance to the case ultimately presented for determination, the plaintiff’s case provided a moving target for the defendant. (Although there were grumbles in Dr Sparks’ written submissions at trial, no issue of procedural unfairness was raised on appeal.) Secondly, the reasoning of the trial judge followed the structure presented by the parties. It would not be possible to recast that reasoning on appeal to comply with a structure not presented at trial. (b) expert opinion evidence – anaesthetists The primary evidence relied upon by Dr Sparks was that of Dr Forrest, an expert anaesthetist called by Dr Sparks. In his principal report (the only report which addressed this issue) the final question and answer were as follows:[45] “5. Did Dr. Sparks, in his anaesthetic management of Mr Hobson, act in a manner that was widely accepted in Australia by peer professional opinion as competent profession practice, at the time the service was provided? Yes. Mr Hobson was a high-risk patient who required major emergency surgery on his spine, in the prone position. From the preceding, Dr. Sparks identified
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urban decay, and traffic fatalities onto the rest of society, while generating huge profits for corporations. In contrast, a more rational society would produce social use values: “functional, aesthetically attractive and durable,” meeting genuine human needs, utilizing “methods of production compatible with humanized labor processes.” Other thinkers in the same period developed related notions. John Kenneth Galbraith advanced his famous thesis of the “dependence effect” applicable to oligopolistic capitalism in The Affluent Society in 1958. He argued that the very process of “production of goods creates the wants that the goods are presumed to satisfy”—a thesis designed to overthrow the neoclassical theory of consumer sovereignty. Joan Robinson in her Richard T. Ely Lecture to the American Economic Association in 1971 (with Galbraith as the chair) raised the issue of the “Second Crisis of Economic Theory.” Mistakenly assuming that Keynes had provided the solution to “the first crisis,” i.e., the level or quantity of production, Robinson went on to contend that now was the time to turn to the “second crisis,” i.e., the quality or content of production. Military production, pollution, inequality, and poverty were all being generated, she argued, not in spite of—but because of—the strategies adopted to expand capitalist growth. In the same year Barry Commoner in his The Closing Circle highlighted the ecological dangers associated, in particular, with the petrochemical industry, which he argued was deeply embedded in an increasingly toxic mode of production driven by profit. Elements of this general ecological critique of monopoly capitalism were drawn together in Allan Schnaiberg’s 1980 treatise, The Environment: From Surplus to Scarcity, one of the founding works of environmental sociology. Already in the 1970s, environmentalists had begun to speak of environmental impact as a result of three factors: population, affluence (or consumption), and technology—with the last two factors, consumption and technology, standing for the role of the economy. The structure of Schnaiberg’s book was clearly derived from this, with chapters two through five focusing, successively, on population, technology, consumption, and production. Schnaiberg’s brilliance was to draw on Marxian and radical political economy to show that the first three of these were conditioned by the fourth, making what he called “the treadmill of production” the fundamental environmental problem. He wrote of the “monopoly capital treadmill,” and insisted: “Both the volume and source of…treadmill production is high-energy monopoly-capital industry.” For Schnaiberg, the monopoly stage of capitalism was geared to labor-saving, energy-intensive production. By constantly displacing labor and producing ever-greater economic surplus, which overflowed corporate coffers, the system generated a growing problem of effective demand—which it then attempted to solve by introducing various extraordinary means of expanding consumption. Contemporary consumption, he argued in Galbraithian terms, did not reveal consumer preferences so much as the profitability requirements of corporations—with consumer choices circumscribed by modern marketing and the technology of the treadmill. Schnaiberg’s realistic conclusion was that attempts to address the ecological problem by focusing on population, consumption, or technology would inevitably fail—since the real problem was the treadmill of production itself. The treadmill of production (or of accumulation), as we have seen, can be explained in Marx’s terms, using the general formula for capital—or M-C-M′, which in the next period of production, becomes M′-C-M′′, and in the period after that M′′-C-M′′′, ad infinitum. For Marx, capital was a system of self-expanding value. It had, as Sweezy was to say, “no braking mechanism other than periodic economic breakdowns.” This is the basis of the standard ecological critique directed at capitalism, which emphasizes the scale effect of capitalist growth in relation to the earth’s limited carrying capacity. Hence, it is rightly assumed that to solve the ecological problem it is necessary to intervene in order to slow down, stop, reverse, and eventually dismantle the treadmill, particularly at the center of the system. Nevertheless, the standard treadmill perspective, if taken by itself, tends to reduce the ecological problem to a quantitative one, deemphasizing the more qualitative aspects of the dialectic, represented today by the promotion of specifically capitalist use values and thus economic waste. Here it is useful to stress that the C in the M-C-M′ relation, standing for the concrete use value aspect of the commodity, has now become transformed under monopoly control into a specifically capitalist use value, which we can designate as CK—to stand for the almost complete subordination of use value to exchange value in the development of the commodity. The problem of M-C-M′ then becomes one of M-CK-M′, in which the qualitative as well as quantitative problems of accumulation/ecological destruction assert themselves through the creation of formal use values. In today’s packaged goods, the package, designed to sell the commodity and incorporated into its production costs, is now the larger part of the commodity. Thus Campbell soup marketers commonly refer to the soup as the mere substrate of the product. Or to take a more economically significant example, since the 1930s the production cost of the motor vehicle has only been a small part of the final sales price, most of which is related to marketing and distribution. As Stephen Fox stated in his Mirror Makers: A History of American Advertising, today’s cars are “two-ton packaged goods, varying little beneath the skins of their increasingly outlandish styling.” The average automobile sold in the United States today has lower fuel efficiency than the Model T Ford. All of this suggests that use value, C, associated with the conditions of production in general, has increasingly given way under monopoly capitalism, to specifically capitalist use value, CK—incorporating all sorts of socially unproductive features, with the object of generating higher sales, and hence realizing profit, M′. It is this relentless reduction of consumption to the needs of capital accumulation by means of the alienation of use value (e.g., making plastic wrapping part of the production price of a loaf of bread) that lies behind the worst aspects of what is mistakenly thought of as “consumerism”: the seemingly endless demand for superfluous, even toxic, products associated with today’s throwaway society. How else do we explain that, worldwide, upwards of 500 billion and perhaps as many as a trillion plastic shopping bags (given away for free) are consumed every year; that some 300 billion pounds of packaging are disposed of every year in the United States; and that 80 percent of all U.S. goods are used once and then thrown away? Much of this is toxic waste; Americans discard seven billion tons of PVC (polyvinyl chloride) plastic—the most hazardous plastic product—annually. In 2008 the Center for Health, Environment and Justice issued a report indicating that an ordinary new shower curtain, which uses PVC plastic, released 108 separate volatile compounds in the home environment over twenty-eight days of ordinary usage, creating a level of these compounds that was sixteen times beyond what was recommended by the U.S. Green Building Council. Quite apart from its toxic nature, the economic and ecological waste embedded in the production and consumption process is enormous. “To say that ‘capitalism has been simultaneously the most efficient and the most wasteful productive system in history,’” Douglas Dowd wrote in The Waste of Nations, “is to point to the contrast between the great efficiency with which a particular factory produces and packages a product, such as toothpaste, and the contrived and massive inefficiency of an economic system that has people pay for toothpaste a price over 90 percent of which is owed to the marketing, not the production, of the dentifrice.” William Morris, who saw the very beginnings of monopoly capitalism, referred to “the mass of things which no sane man could desire, but which our useless toil makes—and sells.” Today we have to recognize that many of these superfluous goods carry enormous costs to the environment and human health. Indeed, many of our most common use values, as Commoner explained, are the products of modern chemistry—introducing synthetic chemicals that are carcinogenic, mutagenic, and teratogenic into production, consumption, and the environment. These goods are cheap to produce (being energy- and chemical-intensive, not labor-intensive), they sell, and they generate high profit margins for corporations. The fact that many of them are virtually indestructible (non-biodegradable) and if incinerated—to prevent them from overwhelming landfills—give off dioxin and other deadly toxins, is viewed by the economic system as simply beside the point. In the face of such contradictions, radical economist Juliet Schor has written of the “materiality paradox,” which suggests that people in our society are not too materialistic, but rather are not materialistic enough. We no longer retain, reuse, and repair products, because we have been taught to expect them to break down or fall apart due to product obsolescence, and then quickly to discard them. Indeed, as a society, we have become entrapped in a still deeper pattern of psychological obsolescence, promoted by modern marketing, encouraging us to throw away what we have only just bought—as soon as it is no longer “new.” The Meaning of Revolution The ecological critique generated by twentieth-century monopoly capital theory—the bare outlines of which I have sought to present here—only adds additional force to Marx’s classical ecological critique of capitalism. Every day we are destroying more and more public wealth—air, water, land, ecosystems, species—in the pursuit of private riches, which turns consumption into a mere adjunct
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msg->context); /* delete from queue */ list_del_init(&pmsg->queue); } return; } /* copy Tx Data */ if (data->cur_trans->tx_buf != NULL) { if (*bpw == 8) { tx_buf = data->cur_trans->tx_buf; for (j = 0; j < data->bpw_len; j++) data->pkt_tx_buff[j] = *tx_buf++; } else { tx_sbuf = data->cur_trans->tx_buf; for (j = 0; j < data->bpw_len; j++) data->pkt_tx_buff[j] = *tx_sbuf++; } } /* if len greater than PCH_MAX_FIFO_DEPTH, write 16,else len bytes */ n_writes = data->bpw_len; if (n_writes > PCH_MAX_FIFO_DEPTH) n_writes = PCH_MAX_FIFO_DEPTH; dev_dbg(&data->master->dev, "\n%s:Pulling down SSN low - writing " "0x2 to SSNXCR\n", __func__); pch_spi_writereg(data->master, PCH_SSNXCR, SSN_LOW); for (j = 0; j < n_writes; j++) pch_spi_writereg(data->master, PCH_SPDWR, data->pkt_tx_buff[j]); /* update tx_index */ data->tx_index = j; /* reset transfer complete flag */ data->transfer_complete = false; data->transfer_active = true; } static void pch_spi_nomore_transfer(struct pch_spi_data *data) { struct spi_message *pmsg, *tmp; dev_dbg(&data->master->dev, "%s called\n", __func__); /* Invoke complete callback * [To the spi core..indicating end of transfer] */ data->current_msg->status = 0; if (data->current_msg->complete) { dev_dbg(&data->master->dev, "%s:Invoking callback of SPI core\n", __func__); data->current_msg->complete(data->current_msg->context); } /* update status in global variable */ data->bcurrent_msg_processing = false; dev_dbg(&data->master->dev, "%s:data->bcurrent_msg_processing = false\n", __func__); data->current_msg = NULL; data->cur_trans = NULL; /* check if we have items in list and not suspending * return 1 if list empty */ if ((list_empty(&data->queue) == 0) && (!data->board_dat->suspend_sts) && (data->status != STATUS_EXITING)) { /* We have some more work to do (either there is more tranint * bpw;sfer requests in the current message or there are *more messages) */ dev_dbg(&data->master->dev, "%s:Invoke queue_work\n", __func__); queue_work(data->wk, &data->work); } else if (data->board_dat->suspend_sts || data->status == STATUS_EXITING) { dev_dbg(&data->master->dev, "%s suspend/remove initiated, flushing queue\n", __func__); list_for_each_entry_safe(pmsg, tmp, data->queue.next, queue) { pmsg->status = -EIO; if (pmsg->complete) pmsg->complete(pmsg->context); /* delete from queue */ list_del_init(&pmsg->queue); } } } static void pch_spi_set_ir(struct pch_spi_data *data) { /* enable interrupts, set threshold, enable SPI */ if ((data->bpw_len) > PCH_MAX_FIFO_DEPTH) /* set receive threshold to PCH_RX_THOLD */ pch_spi_setclr_reg(data->master, PCH_SPCR, PCH_RX_THOLD << SPCR_RFIC_FIELD | SPCR_FIE_BIT | SPCR_RFIE_BIT | SPCR_ORIE_BIT | SPCR_SPE_BIT, MASK_RFIC_SPCR_BITS | PCH_ALL); else /* set receive threshold to maximum */ pch_spi_setclr_reg(data->master, PCH_SPCR, PCH_RX_THOLD_MAX << SPCR_RFIC_FIELD | SPCR_FIE_BIT | SPCR_ORIE_BIT | SPCR_SPE_BIT, MASK_RFIC_SPCR_BITS | PCH_ALL); /* Wait until the transfer completes; go to sleep after initiating the transfer. */ dev_dbg(&data->master->dev, "%s:waiting for transfer to get over\n", __func__); wait_event_interruptible(data->wait, data->transfer_complete); /* clear all interrupts */ pch_spi_writereg(data->master, PCH_SPSR, pch_spi_readreg(data->master, PCH_SPSR)); /* Disable interrupts and SPI transfer */ pch_spi_setclr_reg(data->master, PCH_SPCR, 0, PCH_ALL | SPCR_SPE_BIT); /* clear FIFO */ pch_spi_clear_fifo(data->master); } static void pch_spi_copy_rx_data(struct pch_spi_data *data, int bpw) { int j; u8 *rx_buf; u16 *rx_sbuf; /* copy Rx Data */ if (!data->cur_trans->rx_buf) return; if (bpw == 8) { rx_buf = data->cur_trans->rx_buf; for (j = 0; j < data->bpw_len; j++) *rx_buf++ = data->pkt_rx_buff[j] & 0xFF; } else { rx_sbuf = data->cur_trans->rx_buf; for (j = 0; j < data->bpw_len; j++) *rx_sbuf++ = data->pkt_rx_buff[j]; } } static void pch_spi_copy_rx_data_for_dma(struct pch_spi_data *data, int bpw) { int j; u8 *rx_buf; u16 *rx_sbuf; const u8 *rx_dma_buf; const u16 *rx_dma_sbuf; /* copy Rx Data */ if (!data->cur_trans->rx_buf) return; if (bpw == 8) { rx_buf = data->cur_trans->rx_buf; rx_dma_buf = data->dma.rx_buf_virt; for (j = 0; j < data->bpw_len; j++) *rx_buf++ = *rx_dma_buf++ & 0xFF; data->cur_trans->rx_buf = rx_buf; } else { rx_sbuf = data->cur_trans->rx_buf; rx_dma_sbuf = data->dma.rx_buf_virt; for (j = 0; j < data->bpw_len; j++) *rx_sbuf++ = *rx_dma_sbuf++; data->cur_trans->rx_buf = rx_sbuf; } } static int pch_spi_start_transfer(struct pch_spi_data *data) { struct pch_spi_dma_ctrl *dma; unsigned long flags; int rtn; dma = &data->dma; spin_lock_irqsave(&data->lock, flags); /* disable interrupts, SPI set enable */ pch_spi_set
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A tenth-century manuscript names the compilers as "Leontios the priest and John"; the latter is unidentified. It was first published in 1577. It was based on a fifteenth-century manuscript (codex Vat. gr. 1236). In its original state, it existed as three separate books which discussed dealing with God, with Man and with Virtues and Vices respectively. However, the original codex is currently lost to us. Research on this piece is based on later recensions that were made when the original three books became one. John of Damascus was a proponent for the use of icons during the rise of iconoclasm. Serving as a priest at Mar Saba near Jerusalem, John of Damascus lived under Muslim rule and was safe from persecution for his iconophile views. This could explain why the Parisian manuscript is so heavily illuminated, something not associated with texts that didn’t tell a story. Although this does not prove his position as author, it does strengthen the possibility that he had ties to the Paris manuscript. There are three commonly known recensions: The Vatican, the Rupefucaldian and the Parisinus Graecus 923. They were revealed in a study done by Karl Holl in 1897. However, he found that although the Parisinus Graecus 923, a ninth-century piece, was related to the other two recensions, it did not agree with them. Regardless of Holl’s findings, due to the manuscript’s creation in a time of iconoclasm and its rich use of gold, the piece is still considered very valuable and has been studied to some extent. The images can help researchers reconstruct lost cycles of miniatures prior to iconoclasm. The Parisinus Graecus 923 is the largest and only illuminated Greek florilegium to have survived from the Byzantine era. Description The Parisian manuscript is 35.6 x 26.5 centimeters and is bound in pressed leather with clasps dated to the fifteenth-century. The contents are written onto 394 folios of thick parchment in sloping uncial above the line. The script is organized into two columns of 36 lines that have 13 to 17 letters each. The height of the letters is around 3 millimeters. In the Parisian codex, the excerpts that are placed under each topic follows this order: Old Testament, New Testament, Church Fathers and philosopher Philo Judaeus and the historian Falvius Josephus. Illustrations Of the 1,658 illustrations within the Sacra Parallela Parisinus Graecus 923, approximately 402 are scenic illustrations and 1,256 are portraits. The placement of images in a manuscript usually follows a pattern. However, as a result of its structure as a florilegium text, the author of the Sacra Parallela lacked any notion of design when distributing the images. Some pages are full of illustrations closely followed by several that do not have any. Passages from the Church Fathers are the lengthiest and since patristic texts rarely have narrative illustrations, they are responsible for the long gaps that lack images. The use of gold was not limited and decorated the draperies, architecture and pieces of landscape within the manuscript. This use of gold was intended to create a spiritual and dematerializing effect. However, it was not used due to a lack of stylistic thought. In fact, the coloring of some of the faces actually reveals a good command of the effect of colors left over from the classical tradition. The double lines used for the folds in the draperies are not consistent in style hinting at the fact that there was more than one illuminator working on this manuscript. This is not considered unusual due to the sheer number of illustrations. However, this disparity can also be seen in the design and colors used for the faces. Some individuals, such as Josephus Flavius, show a high degree of individuality. Others, like John Chrysostom, are dull and expressionless. Researchers attribute this second style of facial expressions to repetition and not poor skills. Expressions were used when the text called for it, such as grief when Jacob saw Joseph’s blood-ridden coat. The artists were also skilled as realistically depicting gestures and motions, shown through Abraham’s firm grip on Sarah’s wrist. Overall, the styles that were used by the various artists for the creation of the Sacra Parallela were remarkably similar. The variations are not attributed to the different artists, but the fact that the artists gave the most attention to the scenes that they liked and finished the rest in a routine manner. References Category:9th-century illuminated manuscripts Category:Byzantine illuminated manuscripts Category:Bibliothèque nationale de France collections Category:Eastern Orthodox belief and doctrinePettigrew Scarp Pettigrew Scarp is an escarpment nearly 0.5 nautical miles (0.9 km) long in the south part of Annenkov Island, South Georgia. It is terminated to the southwest by a ridge, and to the northeast by three rock pinnacles. Named by the United Kingdom Antarctic Place-Names Committee (UK-APC) for Timothy H. Pettigrew, British Antarctic Survey (BAS) geologist who worked on the island, 1972-73. Category:Escarpments of Antarctica7767517 58 58 Input data 0 1 data 0=224 1=224 2=3 Convolution conv1 1 1 data conv1 0=32 1=3 2=1 3=2 4=1 5=1 6=864 8=2 ReLU relu1 1 1 conv1 conv1_relu1 ConvolutionDepthWise conv2_1/dw 1 1 conv1_relu1 conv2_1/dw 0=32 1=3 2=1 3=1 4=1 5=1 6=288 7=32 8=1 ReLU relu2_1/dw 1 1 conv2_1/dw conv2_1/dw_relu2_1/dw Convolution conv2_1/sep 1 1 conv2_1/dw_relu2_1/dw conv2_1/sep 0=64 1=1 2=1 3=1 4=0 5=1 6=2048 8=2 ReLU relu2_1/sep 1 1 conv2_1/sep conv2_1/sep_relu2_1/sep ConvolutionDepthWise conv2_2/dw 1 1 conv2_1/sep_relu2_1/sep conv2_2/dw 0=64 1=3 2=1 3=2 4=1 5=1 6=576 7=64 8=1 ReLU relu2_2/dw 1 1 conv2_2/dw conv2_2/dw_relu2_2/dw Convolution conv2_2/sep 1 1 conv2_2/dw_relu2_2/dw conv2_2/sep 0=128 1=1 2=1 3=1 4=0 5=1 6=8192 8=2 ReLU relu2_2/sep 1 1 conv2_2/sep conv2_2/sep_relu2_2/sep ConvolutionDepthWise conv3_1/dw 1 1 conv2_2/sep_relu2_2/sep conv3_1/dw 0=128 1=3 2=1 3=1 4=1 5=1 6=1152 7=128 8=1 ReLU relu3_1/dw 1 1 conv3_1/dw conv3_1/dw_relu3_1/dw Convolution conv3_1/sep 1 1 conv3_1/dw_relu3_1/dw conv3_1/sep 0=128 1=1 2=1 3=1 4=0 5=1 6=16384 8=2 ReLU relu3_1/sep 1 1 conv3_1/sep conv3_1/sep_relu3_1/sep ConvolutionDepthWise conv3_2/dw 1 1 conv3_1/sep_relu3_1/sep conv3_2/dw 0=128 1=3 2=1 3=2 4=1 5=1 6=1152 7=128 8=1 ReLU relu3_2/dw 1 1 conv3_2/dw conv3_2/dw_relu3_2/dw Convolution conv3_2/sep 1 1 conv3_2/dw_relu3_2/dw conv3_2/sep 0=256 1=1 2=1 3=1 4=0 5=1 6=32768 8=2 ReLU relu3_2/sep 1 1 conv3_2/sep conv3_2/sep_relu3_2/sep ConvolutionDepthWise conv4_1/dw 1 1 conv3_2/sep_relu3_2/sep conv4_1/dw 0=256 1=3 2=1 3=1 4=1 5=1 6=2304 7=256 8=1 ReLU relu4_1/dw 1 1 conv4_1/dw conv4_1/dw_relu4_1/dw Convolution
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it continues south to Heilbronn as B-27, the road parallel to and predating the autobahn (A-81). B-27 still leads to Stuttgart and Tübingen. #### Train Travel Heidelberg is 17 minutes from Mannheim, by S-bahn regional train, or 11 minutes on hourly InterCity Express (ICE) trains. These sleek, super-high-speed trains reach 280 kph (174 mph), so travel time between Frankfurt Airport and Mannheim is a half hour. From Heidelberg to Stuttgart, direct InterCity (IC) trains take 40 minutes. Local services link many of the smaller towns. ### Restaurants Mittagessen (lunch) in this region is generally served from noon until 2 or 2:30, Abendessen (dinner) from 6 until 9:30 or 10. Durchgehend warme Küche means that hot meals are also served between lunch and dinner. While credit cards are widely accepted, many small family owned restaurants, cafés, and pubs will accept only cash or debit cards issued by a German bank. Casual attire is typically acceptable at restaurants here, and reservations are generally not needed. Prices in the reviews are the average cost of a main course at dinner, or if dinner is not served, at lunch. ### Hotels This area is full of castle-hotels and charming country inns that range in comfort from upscale rustic to luxurious. For a riverside view, ask for a Zimmer (room) or Tisch (table) mit Neckarblick (with a view of the Neckar). The Neckar Valley offers idyllic alternatives to the cost and crowds of Heidelberg. Driving or riding the train from Neckargemünd, for example, takes 20 minutes. Prices in the reviews are the lowest cost of a standard double room in high season. ### Planning Your Time To fully appreciate Heidelberg, try to be up and about before the tour buses arrive. After the day-trippers have gone and many shops have closed, the good restaurants and the nightspots open up. Visit the castles on the Burgenstrasse at your leisure, perhaps even staying overnight. Leaving the valley toward the south, you'll drive into wine country. Even if you are not a car enthusiast, the museums of Mercedes and Porsche in Stuttgart are well worth a visit. Try to get to Tübingenduring the week to avoid the crowds of Swabians coming in for their Kaffee und Kuchen (coffee and cake). During the week, try to get a room and spend a leisurely evening in this charming half-timber university town. ### Visitor Information Die Burgenstrasse. | Allee 28, | Heilbronn | 07131/564–028 | www.burgenstrasse.de. State Tourist Board Baden-Württemberg. | Esslingerstr. 8, | Stuttgart | 0711/238–580 | www.tourismus-bw.de. Beginning of Chapter | Next Chapter | Table of Contents Previous Chapter | Next Chapter | Table of Contents Exploring | Where to Eat | Where to Stay | Nightlife and the Arts | Sports and the Outdoors | Shopping 57 km (35 miles) northeast of Karlsruhe. If any city in Germany encapsulates the spirit of the country, it is Heidelberg. Scores of poets and composers—virtually the entire 19th-century German Romantic movement—have sung its praises. Goethe and Mark Twain both fell in love here: the German writer with a beautiful young woman, the American author with the city itself. Sigmund Romberg set his operetta The Student Prince in the city; Carl Maria von Weber wrote his lushly Romantic opera Der Freischütz here. Composer Robert Schumann was a student at the university. The campaign these artists waged on behalf of the town has been astoundingly successful. Heidelberg's fame is out of all proportion to its size (population 140,000); more than 3½ million visitors crowd its streets every year. Heidelberg was the political center of the Lower Palatinate. At the end of the Thirty Years' War (1618–48), the elector Carl Ludwig married his daughter to the brother of Louis XIV in the hope of bringing peace to the Rhineland. But when the elector's son died without an heir, Louis XIV used the marriage alliance as an excuse to claim Heidelberg, and in 1689 the town was sacked and laid to waste. Four years later he sacked the town again. From its ashes arose what you see today: a baroque town built on Gothic foundations, with narrow, twisting streets and alleyways. Above all, Heidelberg is a university town, with students making up some 20% of its population. And a youthful spirit is felt in the lively restaurants and pubs of the Altstadt (Old Town). In 1930 the university was expanded, and its buildings now dot the entire landscape of Heidelberg and neighboring suburbs. Modern Heidelberg changed as U.S. Army barracks and industrial development stretched into the suburbs, but the old heart of the city remains intact, exuding the spirit of romantic Germany. #### Getting Here and Around Heidelberg is 15 minutes from Mannheim, where four ICE trains and five Autobahn routes meet. Everything in town may be reached on foot, but wear sturdy, comfortable shoes, since much of the Old City is uneven cobblestones. A funicular takes you up to the castle and Heidelberg's Königstuhl Mountain, and a streetcar runs from the city center to the main train station. From April through October there are daily walking tours of Heidelberg in German (Friday and Saturday also in English) at 10:30 am; from November through March, tours are in German only, Friday at 2:30 and Saturday at 10:30; the cost is €7. They depart from the main entrance to the Rathaus (Town Hall). Bilingual bus tours run April through October on Thursday and Friday at 1:30 and on Saturday at 1:30 and 3. From November through March, bus tours are on Saturday at 1:30. They cost €17 and depart from Universitätsplatz. #### Discounts and Deals The two-day HeidelbergCARD, which costs €14.50 per person or €31.50 for a family of up to five people, includes free or reduced admission to most tourist attractions as well as free use of all public transportation—including the Bergbahn (funicular) to the castle—and other extras such as free entrance to the castle courtyard, free guided walking tours, discounts on bus tours, and a city guidebook. It can be purchased at the tourist-information office at the main train station or the Rathaus, and at many local hotels. #### Timing Walking the length of Heidelberg's Hauptstrasse (main street) will take an hour—longer if you are easily sidetracked by the shopping opportunities. Strolling through the Old Town and across the bridge to look at the castle will add at least another half hour, not counting the time you spend visiting the sites. #### Essentials Visitor Information Heidelberg Tourist Information. | Im Rathaus, Marktpl. | 06221/58444 | Am Hauptbahnhof, Willy-Brandt-Pl. 1 | 06221/19433 | www.heidelberg-marketing.de. Previous Map | Next Map | Germany Maps ## Exploring ### Top Attractions Alte Brücke (Old Bridge). Framed by two Spitzhelm towers (so called for their resemblance to old German helmets), this bridge was part of Heidelberg's medieval fortifications. In the west tower are three dank dungeons that once held common criminals. Above the portcullis you'll see a memorial plaque that pays warm tribute to the Austrian forces that helped Heidelberg beat back a French attempt to capture the bridge in 1799. The bridge itself is one of many to be built on this spot; ice floes and floods destroyed its predecessors. The elector Carl Theodor, who built it in 1786–88, must have been confident this one would last: he had a statue of himself erected on it, upon a plinth decorated with river gods and goddesses (symbolic of the Neckar, Rhine, Danube, and Mosel rivers). As you enter the bridge from the Old Town, you'll also notice a statue of an animal that appears somewhat catlike. It's actually a monkey holding a mirror. Legend has it the statue was erected to symbolize the need for both city-dwellers and those who lived on the other side of the bridge to take a look over their shoulders as they cross—that neither group was more elite than the other. The pedestrian-only bridge is at the end of Steingasse, not far from the Marktplatz. | End of Steing. Alte Universität (Old University). The three-story baroque structure was built between 1712 and 1735 at the behest of the elector Johann Wilhelm, although Heidelberg's Ruprecht Karl University was originally founded in 1386. Today it houses the University Museum, with exhibits that chronicle the history of Germany's oldest university. The present-day Universitätsplatz (University Square) was built over
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and then continue on to checkout to easily complete your reservation today. Reserve convenient parking and save up to 50% CenturyLink Field Parking Heading to CenturyLink Field? Select your event below to get the best spot at the best price. D.C. United at Sounders Suite Access Sat, Jun 9, 2018 7:00 pm Reserve CenturyLink Field parking through SpotHero. Book parking near CenturyLink Field for Seahawks and Sounders games, concerts, and more. Save with SpotHero. New York City FC at Sounders Suite Access Sun, Jul 29, 2018 2:00 pm Reserve CenturyLink Field parking through SpotHero. Book parking near CenturyLink Field for Seahawks and Sounders games, concerts, and more. Save with SpotHero.Adolescents and emergency contraception: update 2011. This review presents the most up-to-date information regarding available methods, safety, efficacy, and availability of emergency contraception for adolescents. Recent reanalysis suggests that previously reported efficacy rates for the levonorgestrel-only method emergency contraception were probably overestimated. A newer and more efficacious method of emergency contraception, ulipristal acetate, was FDA approved in August 2010. Emergency contraception provides young women with an opportunity to prevent pregnancy in the event of unprotected sexual intercourse. Several dedicated products are available commercially in the USA with varying efficacy rates. Barriers, including cost and accessing emergency contraception within the designated time frame, often prevent use among young women.Chestnut-throated huet-huet The chestnut-throated huet-huet (Pteroptochos castaneus) is a large passerine bird of the Rhinocryptidae family. At an average mass of , it is, with the related black-throated huet-huet, the largest rhinocryptid and the third-heaviest tracheophone suboscine behind the giant and great antpittas. It is a stockily-built bird, averaging in length with a predominantly dark brown plumage except for a dark red throat and a pale buff bar on its wind – lacking in the Black-Throated species. For many decades intense debate existed as to whether these two were one species or two, but molecular studies in the 1990s demonstrated that the two species had been separated since before the Patagonian Ice Sheet first formed in southern Chile. The species is found in temperate forests of Nothofagus species and Austrocedrus chilensis on the humid fringe of the Mediterranean climate zone of Chile, chiefly in Biobío, Maule and parts of O'Higgins Regions, and also in a small adjacent area of Neuquén Province in Argentina. The species sometimes occurs in exotic Pinus radiata plantations, but only if there is a dense understory of shrubs, as it cannot move across habitat without dense understory as shown by a study of the fragmented Maulino forest. The Chestnut-Throated Huet-Huet feeds on insects and their larvae, and also a substantial number of seeds and fruit, which it digs for in the forest floor with its long claws. It may be important in the dispersal of certain forest plants. Breeding occurs in spring between September and December, but the burrows ordinarily used to nest are dug during the winter rainy season when the soil is loosest. The burrows can be as much as deep and contain two oval white eggs, which are very large for the bird's size, typically averaging long and wide with a mass of . It is believed both sexes incubate the eggs (as is usual for tracheophone suboscines), but the incubation period is not documented. The huet-huets are well known for their vocalisations, and the song of the chestnut-throated huet-huet is a series of resonant “hoots” that unlike its more southerly counterpart, is typically given as a duet between pairs. The song is higher, softer and faster than the black-throated species, and the call is a “wehk, wehk, wehk” given in alarm. References chestnut-throated huet-huet Category:Birds of Chile chestnut-throated huet-huet Category:Taxonomy articles created by Polbotbody { background: none repeat scroll 0 0 #DADADA; color: #333333; font-family: Helvetica,Arial,sans-serif; font-size: 14px; line-height: 1.4; margin: 0; padding: 0; } .top { color: #EEEEEE; background-color: #3F3F3F; border-bottom: 2px solid #E17600; padding: 5px; height: 32px; font-size: 24px; text-align: center; text-shadow: 2px 2px 1px #666666; } h2 { margin-top: 0px; margin-bottom: 5px; } #content { background-color: #FFFFFF; border: 1px solid #CCCCCC; margin-left: auto; margin-right: auto; margin-top: 10px; width: 900px; padding: 10px; } .demo-container { background: linear-gradient(#F6F6F6 0px, #FFFFFF 50px) repeat scroll 0 0 transparent; border: 1px solid #DDDDDD; box-shadow: 0 3px 10px rgba(0, 0, 0, 0.15); height: 300px; margin: 10px auto 10px; padding: 20px 15px 15px; } #placeholder { height: 100%; width: 100%; } .bottom { color: #888888; font-size: 12px; text-align: center; } .bottom a { color: #888888; } #threshold { border: 0; color: #f6931f; font-weight: bold; width: 60px; } hr { margin-top: 15px; margin-bottom: 5px; border: 0; height: 1px; background: #333; background-image: -webkit-linear-gradient(left, #ccc, #333, #ccc); background-image: -moz-linear-gradient(left, #ccc, #333, #ccc); background-image: -ms-linear-gradient(left, #ccc, #333, #ccc); background-image: -o-linear-gradient(left, #ccc, #333, #ccc); } a { color: #E17600; }Q: How to use a search bar in Beautiful Soup 4 (Python) I am making a dictonary application with the help of Beautiful Soup 4. I am using this website as the dictonary: LINE Dictionary Let's say, for example, I want to enter the word "Hello" into the search bar. How would you do that? Thank you! A: You do not need bs4 to do this, you just need to observe the url and see what changes when you enter something in the search bar: Original: http://ce.linedict.com/#/cnen/home Hello: http://ce.linedict.com/#/cnen/search?query=Hello goodbye: http://ce.linedict.com/#/cnen/search?query=goodbye Then send a request to fetch it. This will work because when you search in the search bar, it just sends a request to the server asking to match what you entered. You can pass the request to the server directly by seeing what it will accept (in use normally with the search bar) and then mimicing this effect. The construction of web database server-client system for functional food factors. In food, other than known nutrients, such as lipid, carbohydrate, protein, vitamins, and minerals, many substances with physiological function and medicinal action exist, and it is contributing to healthy improvement and/or prevention of illness. Although carotenoid, flavonoid and polyphenol, terpenoid, volatile substance and sulfur compounds, peptide, etc. have the function of illness prevention, and research of those non-nutrient functional food factors (FFF) became globally active, the research of this field is not yet done systematically. We evaluate function of FFF and reappraise known knowledge, and this knowledge is standardized and accumulated, aimed at building a web database server-client system which is easy to use for the people and nutritional research. We also collected related data such as chemical characters of FFF from literatures and other source, and formatted them into the database. We constructed the web database server-client system with MySQL database server and Apache web server based on Linux, and used Tomcat JSP engine for data connecting since they were reliable in stability and speed. We are opening the database at http://www.life-science.jp/FFF for test now.Q:
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and metallic, so instead of using rose oil I used 15g of rose oxide to give this effect. An overdose of this product. If you don’t dare or don’t try it all, it smells the same. It’s like doing an experiment, like cooking. You could make béarnaise sauce the traditional way, but why not make it with 2 to 3 different spices in there instead?” I ask Mark if overdosing is a technique that he uses often. He replies that he wants people to smell his fragrances and understand them, to get information directly. “You can do this by overdosing certain products. Everybody was using calone in traces at the start. And I put 20-30% pure. You can dress them up right, use them right. I like it ‘BANG’. Like in Devil in Disguise. It’s rhubarb that’s in your face.” I cringe at the thought of a calone overdose. Sounds like perfume murder to me. I wonder out loud if Mark has ever read Perfume: the Story of a Murderer by Patrick Suskind, and what he thinks of it. “It came out when I was freshly in perfume school in Germany. The book came out and everybody had to buy the book, being in the industry. And I must say that the book was fascinating. It was hard to put it down and I loved the way he described the odours in the whole book. Such as being born amidst all the fish and shit and certain things that were disgusting. It’s not easy to describe odours and fragrances. If you ask somebody about a product and ask them what it smells of, they find it very difficult to describe an odour. This is a shame, because it is one of the most beautiful senses, but it always stops when somebody comes into the metro and says, ‘It stinks,’ but they don’t explain why it stinks or what it smells of. And we see the difficulty. I have two boys who are 13 and 15. I’ve been trying to train them to describe smells when they are young. Instead of just saying that dinner smells nice, they’ve been saying ‘Daddy’s making roast beef, green beans, rice, roast potato.’” “Do you think people should be educated in smells?” I ask. “I’ve been asking the school where my boys go to do demonstrations using oils I have. The excitement when the kids smelt these oils was amazing. Everybody was talking at the same time. So I said to smell it first and let me talk. I definitely see that there is an interest. I think it would be cool if there were some kind of olfactive lessons at school. Make people talk about it, use their noses. Millions of years ago, humans without their noses would have been dead in ten minutes. They smell fear, danger, that there’s something wrong here, animals, whatever. And all this is lost. It’s a shame, really. We’ve got to get back to our roots.” Brilliant. Compulsory olfactory education. Being an educator myself, I can’t ever foresee such a thing happening, but as a perfume lover I certainly do wish with all my heart that all of this would come true. “Speaking of animals, I’m interested in smelling a unicorn. What notes and raw ingredients would you use?” “Well, it looks like a horse. It will need something horsey about it, that’s rather easy. It’s got to be animalic. But not violently animalic. Because it’s a very precious animal, and there’s something like a dream, like a fantasy. But it also needs something solid, because it’s a strong animal with a horn. There’s also something earthy about it as well, but also something elegant. If you would ask me for a flower, I think I would do something around magnolia. It’s a special odour and very delicate. Seldom used. So yes, a magnolia with animalic touches around it.” Now that’s something I’m looking forward to. Share this Joshua is strongly passionate about fragrance (duh!). He enjoys reading articles on Basenotes as well as on other fragrance websites. Recently, he decided to start his own blog as a journal of his thoughts on all things smelly, where he posts anything from reviews to haikus. He would be happy if you popped by his website (listed below) to say hello, of you can write to him at thesmellyvagabond at gmail dot com. Cigarette smoke is a smell that really clings to you, your fingers, your clothes. I would think if he smokes as much as is implied here, would be bathed in the stench of it, even when he is working on a project, and it would pollute his nose during the course of his work. Learning this kind of changed my opinion of him as a perfumer.Ag department proposes raising many fees Thursday Mar 26, 2009 at 12:01 AMMar 26, 2009 at 11:56 AM Illinois’ budget mess has reached the point that the director of the Illinois Department of Agriculture said Thursday it can no longer rely on the state’s general-revenue checkbook to pay for farm programs. Tim Landis Illinois’ budget mess has reached the point that the director of the Illinois Department of Agriculture said Thursday it can no longer rely on the state’s general-revenue checkbook to pay for farm programs. Tom Jennings wants to eventually make the agency self-supporting, and he has proposed starting with fee increases expected to bring in $2.9 million annually. The proposal includes raising more than two dozen fees ranging from fuel-pump inspections to costlier state fair admissions and charges for previously free services. The idea won praise Thursday from Gov. Pat Quinn. “We haven’t any choice. We can’t continue to operate off of general revenue when we’re in the tank like we are,” Jennings said after an address to about 200 participants in the annual Illinois Agriculture Legislative Day. The fee increases are a small piece of the estimated $39.1 million the agriculture department receives in general revenue. It also benefits from federal funds handled by the state. Even if his plans are approved, it will take years to wean the agency from general revenue, Jennings said. However, he added, it’s important to start. “It’s unsustainable right now. There’s not sufficient tax revenue flowing to the general revenue fund,” said Jennings. Quinn said after addressing the farm group that “modest increases” in fees should play a role in balancing the state budget. “We’re going to have to do the best we can with reasonable fees to provide those services,” said Quinn. “If we don’t do it, the state will be insolvent. I don’t believe in letting that happen. It won’t happen on my watch.” The legislative director of the Illinois Farm Bureau said the group isn’t necessarily opposed to fee increases, but farmers also want assurances the money won’t be diverted for other state expenses. “We have gone that way in many programs, but with the fund sweeps that we’ve seen, we take the funds that our members pay, and then they sweep them, and they go into the general revenue pot,” said Kevin Semlow. In the past, he added, some fees have gone up, but services to farmers have still been cut. Semlow said a state road construction bill also is high on the priority list for the farm group for the spring legislative session. “If there is a capital bill, now is a time to talk about those things and say that, if we’re going to increase road funding, we need to be looking at more access for our farmers to get to the markets,” Semlow said. Tim Landis can be reached at (217) 788-1536.Corporate Basketball-Tuesday-Season 3-DSW Dates Duration Timings Welcome to Corporate Basketball League at DSW, located at Dubai World Trade Center. Payment terms: Pay online and get 15% off team fee. Discount is valid for online payments only and expires on 13th of June Paying online via your credit card is the best way to guarantee your spot All teams/individuals must pay before league starts · Games will not start if payment has not been received by week 2 - walkovers will be awarded against teams who don't pay · Paying on time allows us to better gauge player/team commitment AHEAD of the league start date which means few no-shows and a better playing experience! Refund policy DUPLAYS only grants refunds in certain cases of injury, job relocation, or in agreed special circumstances. The rule is to refund a prorated amount based on the number of weeks of participation plus one. 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of the VA groups on or near the surface of the particles without any significant hydryolysis of the interior. Thus, according to the processes of this invention, the conditions of EVA stock temperature, the composition and temperature of the treating medium, and the concentration of the alkali in the medium are controlled so that sufficient agglomeration-resistance is imparted in the shortest possible contact time (a few seconds to a few minutes). Thus the hydrolysis will proceed very rapidly on the surface of the EVA copolymer and then essentially stop, so as to prevent significant hydrolysis from occurring within the pellets. As has already been pointed out, the known processes are not generally useful for the surface treatment of EVA copolymers containing more than about 35% by weight of VA since it is desirable that the EVA copolymer not dissolve, but more importantly that the surface treatment be accomplished rapidly without substantial overall hydrolysis. Moreover, there is no teaching in any of the heretofore known art that the treatment of already agglomerated pellets with a base can reverse the agglomeration process, so that the individual pellets are substantially regenerated from the agglomerates, and are at the same time additionally made sufficiently more resistant to blocking and sticking to prevent subsequent reagglomeration either at room temperature or at the temperatures and pressures encountered in normal use. In fact, it would logically be expected by those skilled in the art that such treatment of pellet-agglomerates with a base would merely render the agglomerates themselves resistant to sticking and blocking. The regeneration of the original, individual pellets from the pellet agglomerates is quite unexpected and surprising.The present invention is generally directed to performing authentication on a thin client using an independent mobile device. Authentication on a thin client is typically performed using a username and password as is common with most personal computers. Several problems exist with this typical authentication approach. First, when passwords and their corresponding questions are stored online, they are susceptible to hacking. Second, many users write their passwords down near the computers to which the passwords apply making a breach easily obtainable to anyone with physical access to the location of the computers. Third, many people use passwords that can be easily guessed based on information about the user that is available on social networking websites. In addition to these security issues, it may also be difficult for the user to manage his or her passwords. This is especially true when administrators apply strict security requirements when selecting passwords. For example, if a user is required to include numbers or special characters in the password or change the password frequently, he or she will be more likely write down the password or use a meaningful word or phrase within the password so that it is easier to remember. In short, regardless of the efforts that are made to enhance its security, password-based authentication will remain susceptible to hacking. To address these concerns, many computers now include biometric scanners that allow biometric-based authentication to be performed. For example, many laptops, tablets, and smart phones include fingerprint sensors that allow a user to login with a fingerprint. Unfortunately, most thin clients do not include fingerprint sensors or other biometric scanners due primarily to the fact that their inclusion would render the thin clients too expensive (or no longer “thin”) thereby defeating their purpose. Therefore, to allow biometric-based authentication in a thin client environment, it would typically be necessary to invest in biometric scanners that could be connected to the thin clients. The same is true for smart card-based authentication or other hardware token-based authentication techniques. Therefore, for cost and management reasons, these approaches will oftentimes not be suitable. Currently, some solutions exist that allow a user to unlock a computer using another device. For example, the FingerKey app allows Mac users to unlock a Mac using the Touch ID fingerprint sensor of an iPhone. For FingerKey to work, a companion application, FingerLock must be installed on the Mac. During the login process, the FingerKey app will prompt the user to scan his fingerprint on his iPhone and then communicate a successful scan to the FingerLock application which in turn will input the password into the password text box on the Mac. In essence, FingerKey provides a way for the user to input his password into the Mac without actually having to type it on the keyboard. Because FingerKey only automates the password login process, it will not function in a corporate environment (e.g., in an Active Directory environment).New Falkirk, Banori Outworlds Alliance 2 August 2784, 1845 Local Time Peter Davenport pulled the ball cap down a little tighter before opening the door to leave the grocer. His pack was stuffed with his purchase of freeze-dried meals, the last item on the list of supplies he’d be taking on this leg of the journey to his new home. He ducked his head to avoid the brunt of the wind-driven rain and jogged to the bus stop on the other side of the street. It had a small, covered shelter, though it was of little use against the storm. Huddling into the corner, he put it to the best use he could, managing to keep the blowing sheets of rain from soaking his clothes through. The disposable data tablet he’d purchased a few days earlier buzzed in his jacket’s inner pocket, it’s chirping barely audible over the pounding of the rain. He pulled it out and thumbed the answer button, not having to look at the caller identification display. He’d purchased the data-tab after learning of the change of schedule on the freight hauler he’d booked passage on, and the dropship’s passenger liaison was the only person with the number. He answered with an upbeat, “Frank, here.” “Mr. Garrison, this is Harold Nobora. We spoke earlier this week about your travel plans?” “Right! I’m on my way, Mr. Nobora. I just stopped for a few last minute things. I’ll be there in less than twenty minutes.” “Excellent. Boarding ramp is up at 1920, and we’re gear up at 1930 sharp. Captain Mills hates to be late and we’re already four days later than we’d planned.” The sound of heavy machinery was in the background and he sounded distracted, even over the poor connection. Pete made sure that Frank Garrison’s excitement was obvious, “I’ll be there. I’m ready to leave this rock!” “Great. See you soon- SHIT! Hey, watch the pressure in that tan-” the line when dead as the liaison killed the connection, his attention apparently needed elsewhere. Pete, or Frank Garrison (the identity he has assumed here on Banori for his stay,) had guessed the first time he’d met the passenger liaison that he also doubled as the cargomaster on the ship, keeping him quite busy. He was surprised that the man had taken the time to contact him at all, considering. His use for the data-tab at an end, Pete flipped it over in his hand and smashed it against the lip of the 55-gallon drum that doubled as a waste container at the bus stop. The data-tab split, the two broken halves hanging together by a ribbon of wires. He tossed the ruined device into the bin, satisfied that the micro-board inside of it was broken beyond repair. He hadn’t inputted any unnecessary data onto the device, but there wasn’t any point in taking chances, he reasoned. Certainly not after getting this far, and being so close to the end of his journey. The bus rounded the corner and came to a halt in front of the stop, splashing muddy water from the gutter up into the shelter. A quick hop behind the waste drum saved Pete the indignity and discomfort of soaked pants on his ride to the starport. The door swung open, and a man who looked old enough to be his grandfather smiled from the driver’s seat. “Just so you know, I’m headed straight for the starport.” “Well, that’s where I’m headed,” Frank beamed back from the shelter, oblivious to the rain. “Then get in here, son. You’ll catch cold in this rain,” chided the driver. Frank hopped onto the bus and made sure to take a seat far enough back to avoid conversation with the chatty driver, but not so far back it was obvious. There were two other people on the bus, both starport workers by the looks of their clothes. One snoozed silently in the back while the other sat across the isle from Frank, engrossed in a rather loud game on his data-tab. Frank leaned forward and shrugged off the pack, setting it on the seat beside him. Leaning back, he closed his eyes and relaxed a bit. He was less than 45 minutes from being off Banori and a step closer to his new home on Praxton. The gentle sway of the bus over the road out of town relaxed Pete, who had barely slept since arriving on planet over a week ago. Thankful for a chance to close his eyes, his mind wandered to the events that had lead him where he was now, light-years from his home and everything he’d ever known. In mid-2766, just months before Stefan Amaris’ bid to overthrow the Star League, Pete had been transferred to Terra. A young lieutenant in the Star League Defense Force’s 77th Special Operations Group, the “Blackhearts” as they’d come to be known, he had been conducting counter-terrorism operations out in the Taurian Concordat. The orders he’d received, awarding him six months of R&R on Terra before taking up duties at the
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)$, and $\nu_t=0.80(6)$. Using a generalized hyperscaling relation valid for theories with anisotropic interactions we obtained $\nu_s=0.90(5)$ and $z=0.89(8)$. Our preliminary $z<1$ estimate implies that the quasiparticles are stable based on energy-momentum conservation. The value of the physical critical coupling $\lambda_c=2.54(2)$ implies that freely-suspended graphene is an insulator in agreement with [@Drut2009]. We also presented the first results for the quasiparticle dispersion relation and within the accuracy of our simulations we showed that the free field Fermi velocity is renormalized. Simulations with higher resolution in momentum on larger spatial lattices are currently in progress for a more accurate study of the dispersion relation. [xx]{} K.S. Novoselov, A.K. Geim, S.V. Morozov, D. Jiang, M.I. Katsnelson, I.V. Grigorieva, S.V. Dubonos, and A.A. Firsov, Nature (London) [**438**]{} (2005) 197. G.W. Semenoff, Phys. Rev. Lett. [**53**]{} (1984) 2449. 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[**35**]{} (1975) 1678. Overcoming confirmation jitters For myself, an eighth-grader preparing for confirmation, it means a lot to know that many great saints like Mother Teresa and St. Thomas the Apostle had doubts about God during their lives. When I was younger, adults in my life — like my parents and priest ­— seemed certain about God’s plan and expectations for us. Now, thanks to this article and the words of Father Stephen Bevans, I understand the difference between faith and certainty. This will aid me in my journey toward confirmation and a more faithful relationship with God. I hope to always remember that even in my doubts, Christ is always there to light the way. — Ben Kindberg, via online comments Mass requirement At the October synod, Pope Francis wants to discuss Catholicism as seen by our modern generations. I would hope they would re-evaluate the commandment “thou shalt keep holy the Sabbath.” I would hope God’s judgment at my time of death is based on the totality of my Catholicism, not on a single misstep. I think Sunday Masses should be considered a blessing and an inspiration for a total Sunday observance of keeping holy the Sabbath, not a demand “or else.” — Bill Bandle, Manchester, Missouri Deny marriage If a man walked in and asked to be ordained a priest, the Church wouldn’t administer the sacrament to him. So why can two people walk in and ask to be married? Cardinal Collins, in discussing annulments, notes that “after careful study the Church (may) discover that (a couple) did not truly make a binding commitment.” Other studies show that divorce rates are very low among Catholics who go to church and pray together. Perhaps the time for “careful study” is during the mandatory marriage preparation classes, and if it is discovered that the couple are not making a “truly binding commitment,” refuse them the sacrament of marriage! We would consider in some cases denying them the Eucharist, why not marriage? — Tom Salapatek, Canton, Michigan Pray for war Thanks to Russell Shaw for his column. Our option in Iraq is to fall on our knees and beg God’s forgiveness for the slaughter of his children and for the destruction of their lives, health, economy, education, culture, infrastructure, egalitarian status of women, etc. There was bragging that we would “bomb them back into the stone age” and indeed we did. It had been a long climb to the achievements which we destroyed, and it will be a long climb back. War has let loose demons aplenty, and Satan laughs at the chaos, hatred and bloodshed. The same war agenda seeks a repeat performance in Iran. Let us take up our rosaries and pray a mighty defense against that happening. — Lynn Ellen Dixon, Woodward, Pennsylvania Healing refugees Everything in this article is true. But because I fled the civil war of El Salvador in 1989, I know that there is more to this crisis. America made a big mistake by simply sending these refugees back to their nations without first healing their wounds. So what we have here now are the partial results of this big mistake. And so America should not only welcome these refugees, but America should also set up a healing process specifically for them. Their healing just might be what Central America needs to overcome the images and news of those children who make us cry and cringe.1 of 13 Associated Press 25. Nebraska Cornhuskers (4-8 in 2018) Despite a four-win campaign last year, the Scott Frost hype train has stormed into the nation's consciousness this offseason. Nebraska returns a true standout quarterback in Adrian Martinez, who threw for 2,617 yards and ran for 629 as a freshman. The concern is that an objectively bad defense lost six of its top contributors. Skepticism is understandable no matter the ranking Nebraska will probably receive. 24. Northwestern Wildcats (9-5) The defending Big Ten West Division champions must replace four-year starter Clayton Thorson, but expectations aren't getting lower. Clemson transfer Hunter Johnson, a 5-star in the 2017 class, is the highest-rated quarterback in program history. Northwestern should have a reliable defense led by Paddy Fisher and Joe Gaziano, but its upside hinges primarily on Johnson's performance. 23. Washington State Cougars (11-2) Gardner Minshew turned Wazzu into one of last season's top breakout teams. Will the offense find another gem within the competition between Gage Gubrud, Trey Tinsley and Cammon Cooper? Thanks to four straight years with at least eight wins, head coach Mike Leach has probably—and rightfully—earned the voters' benefit of the doubt. However, a road-heavy slate has the potential to smother the wrong quarterback. 22. Army Black Knights (11-2) Army's inclusion goes beyond the requisite "non-Power 5 team in the 20s" part of the preseason poll. The offense returns quarterback Kelvin Hopkins Jr. behind an experienced line, and the schedule is extremely soft. Six of Army's opponents won three games or fewer in 2018, and two more are Football Championship Subdivision schools. 21. Iowa State Cyclones (8-5) Iowa State's primary appeal is a promising young quarterback in Brock Purdy. Over nine starts, he posted a terrific 10.2 yards per attempt while providing a decent rushing threat, too. But can the Cyclones withstand the departures of David Montgomery and Hakeem Butler? While keeping the entire offensive line intact is valuable, Iowa State desperately needs a couple of reliable playmakers to emerge.Acid-induced equilibrium folding intermediate of human platelet profilin. The acid-induced unfolding of human platelet profilin (HPP) can be minimally modeled as a
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field { } ::-webkit-datetime-edit-day-field { } ::-webkit-datetime-edit-year-field { } ::-webkit-inner-spin-button { } ::-webkit-calendar-picker-indicator { } I would also highly recommend using the following in order to turn off the default browser styles; I've found this to be especially useful when working with mobile browsers: input[type="date"] { -webkit-appearance: none; } A: Chrome (v79): input[type='date']::-webkit-clear-button, input[type='date']::-webkit-inner-spin-button { display: none; } Firefox (v73): Firefox has only the clear button for date inputs. To remove it, the field should be made required. <input type=’date’ required=’required’ /> Safari (v13): Safari doesn’t support type=’date’. Russell T Davies called on “the ghost of Doctor Who” – as well as one of the show’s best-loved living stars – to help inspire his new BBC production of A Midsummer Night’s Dream. In the new issue of Radio Times, Davis reveals that when he was planning his adaptation of Shakespeare’s comedy, the first person he turned to for advice was “Shakespeare expert” David Tennant – and he wasn’t disappointed. “When I embarked on this production, I scrolled down my phone to seek the advice of the greatest expert in Shakespeare I know, David Tennant,” says Davies. “Sadly, he wasn’t free to appear in this production – he would have made a great Moth – but he suggested some brilliant jokes. When you see the gag with Bernard Cribbins and a handpump, that’s copyright DT.” But Davies admits that Doctor Who had also been on his mind for other reasons when he approached the play. As a childhood fan of A Midsummer Night’s Dream, who says starring in it at school “changed my life”, Davies wanted to capture some of the same magic he had brought to Doctor Who when he ressurected it for both a new generation and for existing fans back in 2005. “The ghost of Doctor Who was invoked deliberately. When I brought the show back in 2005, I wanted to make it feel brand new, but I also wanted to stir that ancestral memory of something once loved. And I think a Midsummer Night’s Dream is the same. It wasn’t just my school putting on a production, it was 100,000 schools. This is the kids’ play!” Read the full interview with Russell T Davies in the new issue of Radio Times magazine, on sale from TuesdayFor many years personal checks, travelers checks, money orders, traditional currency and the like were the most popular means for paying for goods or services. These payment means, however, were often difficult or impossible to replace if lost or stolen. This is typically true, since these means of payment were disposable in that they were typically single-use devices, meaning that once the devices were used, the ability to reuse the devices was instantly lost to the user. As such, recent years has seen the development of transaction cards, such as credit cards, debit cards, smart cards, pre-paid cards and the like as a popular substitute for traditional means of payment. A transaction card is about the size of a driver's license, business card or the like making it easier to guard against theft by storing while maintaining control of the transaction card for later re-use. However, although transaction cards are typically configured for re-use, they, like the traditional means of payment discussed above, are often misplaced or lost by the user. To enhance the chance that a user will have uninterrupted use of a transaction device conventional transaction account providers are increasingly providing transaction devices which are better suited for securing against loss or theft. For example, the transaction device may be embodied in a form factor attachable to the accountholder's person or to an often used personal article, such as a keychain, fob or tag. In this way, the user has increased security against loss, since the personal article is handled frequently. The security provided by this attachment method is limited, however, since the transaction device may still need to be handed over to a merchant to complete a transaction. As such, account providers have increasingly sought ways to enable the user to complete a transaction without the necessity for the user to relinquish control of the device. One such method involves providing a transaction device which is configured to transmit account payment information through a radio frequency transmission. A typical example is a Radio Frequency Identification (RFID) system. Like barcode and voice data entry, RFID is a contactless information acquisition technology. RFID systems are wireless, and are usually extremely effective in hostile environments where conventional acquisition methods fail. One of the more visible uses of the RFID technology is found in the introduction of Exxon/Mobil's Speedpass® and Shell's EasyPay® products. These products use transponders placed in a fob or tag which enables automatic identification of the user when the fob is presented at a Point of Sale (POS) device. Fob identification data is typically passed to a third party server database, where the identification data is referenced to a customer (e.g., user) credit or debit account for completion of a transaction. By providing a RFID transaction device (e.g., fob) as described above, transaction account providers are able to attract account users in increasing numbers. The account users often prefer account providers which offer the RFID transaction device option because of the convenience of use and the security using a RF transaction fob provides. As such, because of the increased popularity and benefits associated with RFID transaction devices, many banking and financing institutions, department stores, petroleum companies and other organizations have developed their own RFID transaction devices for use by the organization's consumers. The proliferation of RFID transaction devices has given the consumer many choices concerning which RFID transaction device to use. As such, device providers attempt to find ways to distinguish their device over a competitive device. In response to this competition, RFID transaction device providers have developed devices including different shapes and appearances. The variations are designed to encourage use of the device and to distinguish the device from other devices on the market. Typical RFID transaction device providers encourage use of their transaction devices by making the device more aesthetically pleasing. For example, the transaction device provider may include on the surface of the device a logo, picture, apparition, or the like which holds some sentimental or endearing value to the user. The transaction device provider may address the aesthetics of a device by altering the shape of the form factor in which the RFID circuitry may be included. While altering the appearance of the surface or shape of the device has proven successful for encouraging use of a particular transaction device, transaction device providers continue to look for other ways to improve the appearance of the device. As such, a system and method is desired which addresses the aesthetics of a transaction device with little regard for the device surface or shape.Tight-skin (Tsk) maps on mouse chromosome 2 within the region of linkage homology with human chromosome 15. The tight-skin (Tsk) mutation has been mapped to mouse chromosome 2 between the visible markers pallid (pa) and agouti (a). The phenotype observed in Tsk heterozygotes includes a thickened dermis that is tightly adherent to underlying tissues, increased production of collagen and other matrix proteins in the dermis, an enlarged heart, overgrowth of bones, scoliosis, and emphysematous lungs. Although it is known that the mutation is semidominant and that homozygous Tsk/Tsk mice die at 7 or 8 days in utero, the actual defect leading to the distinct heterozygous and homozygous phenotypes is unknown. To facilitate the positional cloning of Tsk, an interspecific backcross between C57BL/6J Tsk/+ and Mus spretus has been conducted. Our data link Tsk to cloned genetic markers and indicate the order pa-B2m-Tsk-Fbn-1-II-1a-a.Washo language Washo (or Washoe; endonym ) is an endangered Native American language isolate spoken by the Washo on the California–Nevada border in the drainages of the Truckee and Carson Rivers, especially around Lake Tahoe. While there are only 20 elderly native speakers of Washo, since 1994 there has been a small immersion school that has produced a number of moderately fluent younger speakers. The immersion school has since closed its doors and the language program now operates through the Cultural Resource Department for the Washoe Tribe. The language is still very much endangered; however, there has been a renaissance in the language revitalization movement as many of the students who attended the original immersion school have become teachers. Ethnographic Washo speakers belonged to the Great Basin culture area and they were the only non-Numic group of that area. The language has borrowed from the neighboring Uto-Aztecan, Maiduan and Miwokan languages and is connected to both the Great Basin and California sprachbunds. Regional variation Washo shows very little geographic variation. Jacobsen (1986:108) wrote, "When there are two variants of a feature, generally one is found in a more northerly area and the other in a more southerly one, but the lines separating the two areas for the different features do not always coincide." Genetic relations Washo is conservatively considered a
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oria, Illinois, USA, with severe acute respiratory distress syndrome (ARDS). The transfer was from a nearby community hospital where she had sought care 4 days earlier for influenza-like symptoms consisting of cough, wheezing, progressive shortness of breath, nausea, and vomiting. In the community hospital emergency department, she mentioned that 2 children at home had similar symptoms and that her mother had recently been hospitalized with an acute respiratory illness. Despite treatment with supplemental oxygen, nebulized albuterol, and intravenous antimicrobial drugs for community-acquired pneumonia, her condition deteriorated, and she was intubated on hospital day 2, after which the antimicrobial drug treatment was changed from intravenous ceftriaxone and azithromycin to intravenous vancomycin and piperacillin/tazobactam. Results of bronchoscopy performed on hospital day 4 were unremarkable, and bacterial cultures of alveolar lavage samples were negative. Her transfer to St. Francis Medical Center was prompted by persistent mechanical ventilation requirements of 100% fraction of inspired oxygen; positive end-inspiratory pressure of 12 mm/H~2~O consistent with classic ARDS (hypoxemia, indicated by a ratio of arterial oxygen partial pressure to fractional inspired oxygen \<200 mm Hg); and bilateral infiltrates on chest radiograph ([Figure](#F1){ref-type="fig"}) without evidence of left heart failure ([@R4]). On hospital day 8 (cumulative), a nasopharyngeal swab sample was tested by FilmArray Respiratory Panel multiplex PCR (BioFire Diagnostics, Salt Lake City, UT, USA); results were positive for rhinovirus/enterovirus. That day, intravenous methylprednisolone therapy was initiated. ![Chest radiograph obtained (with portable machine) of semirecumbent adult patient with enterovirus D68--associated acute respiratory distress syndrome on hospital day 3.](14-2033-F){#F1} During a prolonged hospital stay, the patient required mechanical ventilation for 32 days, underwent a second bronchoscopic evaluation, required a percutaneous tracheostomy (and subsequent decannulation), and underwent endoscopic gastrostomy tube placement (and removal). She was discharged from the hospital after 55 days and ultimately recovered completely. To determine the etiology of the clinical syndrome for the patient reported here, molecular diagnostic testing of respiratory tract clinical specimens was required. Institutional review board approval was obtained for molecular diagnostics and sequencing of the patient's nasopharyngeal swab specimens and bronchoalveolar lavage (BAL) fluid samples. The FilmArray platform is capable of detecting enteroviral infections caused by EV-D68 but cannot differentiate between rhinoviruses and enteroviruses ([@R5]). Confirmation of EV-D68 requires EV-D68--specific PCR ([@R6]). A novel, research-based diagnostic modality that is capable of rapid identification of viral pathogens directly from clinical specimens is the combination of PCR and electrospray ionization mass spectrometry (ESI-MS) ([@R7]), which was instrumental in early recognition of the novel pandemic strain of influenza A(H1N1) virus that emerged in 2009 ([@R8]). For a variety of viral pathogens, PCR/ESI-MS sensitivity is 94% and specificity is 98% ([@R9]). In this case, PCR/ESI-MS detected a human enterovirus from the right middle lobe and left lingular segment BAL fluid samples. For the assay, 2 primer pairs were used; both confirmed the presence of human enterovirus, but only 1 matched the signatures for EV-D68. For confirmation, we pursued testing with EV-D68--specific PCR, which was performed by the Special Projects Laboratory of the Washington University Department of Pediatrics. This assay amplifies a segment of the viral protein 1 gene, which enables discrimination of EV-D68 from other enteroviruses and rhinoviruses (K.M. Wylie et al., unpub. data). The nasopharyngeal swab sample and the right middle lobe and lingula BAL fluid specimens were positive for EV-D68. PCR/ESI-MS of BAL fluid followed by EV-D68--specific PCR testing of 1 nasopharyngeal swab and 2 BAL fluid samples confirmed our clinical suspicion of ARDS secondary to EV-D68 in an adult. The patient's history of contact with sick family members and clinical signs (nonproductive cough, nausea, and vomiting) were suggestive of a viral infection. Lessons learned from the emergence of swine-origin influenza A(H1N1)pdm09 virus and recognition (in the midst of the pandemic) that younger age and obesity were risk factors for severe disease were also suggestive of a viral respiratory infection. We are developing a specific rapid molecular assay for EV-D68, which should help clinicians recognize when EV-D68 is present in the community. During those times, EV-D68 infection should be included in the differential diagnosis of severe respiratory infection. Documentation of EV-D68 infection may help with clinical management for individual patients and minimize unnecessary use of antimicrobial drugs within communities. *Suggested citation for this article*: Farrell JJ, Ikladios O, Wylie KM, O'Rourke LM, Lowery KS, Cromwell JS, et al. Enterovirus D68--associated acute respiratory distress syndrome in adult, United States, 2014 \[letter\]. Emerg Infect Dis. 2015 May \[*date cited*\]. <http://dx.doi.org/10.3201/eid2105.142033> We thank the staff at Washington University in St. Louis, MO, USA, particularly Anthony Orvedahl, for assistance with EV-D68--specific PCR. AFFORDABLE ART GUIDE BY MAV ARCHIVES Sunday, November 26, 2006 Montezuma's Chocolate On my way back from meeting with Jonathan Levien and Nipa Doshi, I couldn't resist the temptation of stopping in the Montezuma's chocolate store in Spitalfields (right next to the market) to pick up a few gifts for my husband, an incurable chocoholic. There are no traces of the bar chocolate I brought back but there is still a tiny bit of this spicy drinking chocolate left. The truth is that I am not sure he got to taste very much of it because I drank it all. Unlike many other drinking chocolates which are just powder, this one also has flakes of chocolate mixed with red pepper. If you don't like the spicy kick, there are three other kinds, including with white chocolate! The cannisters make great gifts, or just give a box full of assorted gifts, no one will waste any time looking at the packaging! Organic, gluten free and handmade in Sussex. 346 N.E.2d 566 (1976) Bennie Gray DANIELS, Appellant (Defendant below), v. STATE of Indiana, Appellee (Plaintiff below). No. 475S106. Supreme Court of Indiana. May 14, 1976. *567 John G. Bunner, Evansville, for appellant. Theodore L. Sendak, Atty. Gen., Joseph J. Reiswerg, Deputy Atty. Gen., Indianapolis, for appellee. HUNTER, Justice. Defendant-appellant, Bennie Gray Daniels, appeals from his conviction of first degree murder. Appellant entered a plea of not guilty and moved for a change of venue from the county. Appellant entered a special plea of insanity on November 4, 1974. Upon his conviction appellant was sentenced to life imprisonment at the Indiana State Prison. On appeal three contentions of error are made by appellant: 1. The verdict of the jury was not supported by sufficient evidence; 2. The trial court erred in overruling appellant's motion for change of venue from the county; 3. The trial court erred in not removing the cause from the jury. I The first issue presented is whether the verdict is supported by sufficient evidence. Appellant contends that the state failed to carry its burden of proof concerning appellant's sanity. Once an accused has raised the issue of his sanity, the burden is upon the state to prove that the accused was sane beyond a reasonable doubt. Young v. State (1972), 258 Ind. 246, 280 N.E.2d 595; Flowers v. State (1956), 236 Ind. 151, 139 N.E.2d 185. The issue of one's sanity is to be resolved by the trier of fact. Sotelo v. State (1975), Ind., 342 N.E.2d 844; Johnson v. State (1970), 255 Ind. 324, 264 N.E.2d 57. When reviewing the sufficiency of the evidence to support a determination by the trier of fact, we consider only that evidence which is most favorable to the judgment, together with all reasonable inferences to be drawn therefrom. When there is substantial evidence of probative value to support the jury's verdict, the conviction will not be set aside. Henderson v. State (1976), Ind., 343 N.E.2d 776; Sotelo v. State, supra. The evidence in support of appellant's sanity is as follows: Two court-appointed medical experts testified that in their opinion, while appellant did exhibit signs of inadequate personality development, he did not suffer from any mental illness or disease. One of the experts testified that there was a "remote possibility" that the appellant could not control his actions. In addition, the same expert was of the opinion that Daniels was able to comprehend the wrongfulness of his conduct. Furthermore, the arresting officers testified that the appellant appeared to them to be very calm and seemingly unperturbed at the time of his arrest shortly after the murder had occurred. Appellant's argument focuses upon the state's failure to call any witnesses of
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is used. In this case, there is connected at one end of a first optical waveguide a coupler which receives a light beam from a first light source and sends a light beam to a first photodetector. Between the other end of the first optical waveguide and the semi-transparent mirror there is disposed a polarization splitter, which generates a linearly polarized light beam, an optical sensor and a retardation plate. The mirror reflects a part of the light beam and transmits the other part. On the other side of the mirror there is connected a second optical waveguide, which leads to a second coupler with light source and photodetector. As in the arrangement according to FIG. 2, light beams are emitted with a time shift via the two optical waveguides. In this case also, reflections take place at optical boundary surfaces.Chemical reactions in the OceanGrace Wright F mod A reactant is a substance that takes part in and undergoes change during a reaction. A product is what comes out of that reaction. NaCl+H2O---> salt water Endothermic takes in energy just like this bottom feeder takes in its energy from eating off the bottom of the ocean. Exothermic releases energy just like these deep sea vents. Solid is a state of matter that has tightly packed particles and definite shape and volume. A liquid has loose particles with no definite shape but definite volume. A gas has chaotic particles with no definite shape or volume. Lastly, aqueous means dissolved in water. Synthesis-two or more things combined to make one big compound C+O2--->CO2 Decomposition-breaks down big compound into two or more things. CO2---> C+O2Special Internet Offer Established 1982 Over 30 years of service Protectors of Public Health and Property Take $30.00 OFF any complete mouse, squirrel, skunk, insect or wildlife removal service Take $20.00 OFF any other service Battleline Pest Managment is a family-owned business established in 1982 by Jack & Holly Evangelous in Marlborough, Massachusetts. We are family-owned and operated to provide you with the security and peace of mind you deserve. We will work closely with you and your family in an effort to provide a pest-free environment and will do everything possible to keep you our customer for life. That is our true promise. Thank you for visiting our website. If you have any questions, comments or suggestions, we would love to hear from you.As more than 100 fires burn across the north, some Saskatchewan cabin owners have seen their property literally go up in smoke, while others are spraying their homes with water to douse flying sparks. George Montgrand, whose cabin is on the Clearwater River Dene Nation in northwestern Saskatchewan, saw his home destroyed, along with a truck. The charred remains of George Montgrand's cabin in northern Saskatchewan. (Submitted by George Montgrand) "If it took you two years, by yourself, to build something like that, and come back and see it only ashes and smoke, it's kind of hard," he said. "I try to fake it, like there's nothing wrong, but that's not it at all. I'm just trying to get my kids not to worry so much about it." Montgrand and his family live in the cabin year-round, hunting and living off the land. The cabin was an essential part of that. - George Montgrand "I stay there all through the year — it's home to me," he said. "The food price is so high up here and I can't live with that. I kill a moose and it'll last me a whole year." Montgrand thinks firefighting should be more aggressive and should be started sooner. "They need to know people use this north country for their livelihood," he said. "There's a lot of people that still live off the land. Not everybody stopped doing that." While his cabin is nothing but ash now, Montgrand said he will rebuild. "I'm going back there. I'm not giving up," he said. "It'll grow back. I don't know how many years it will take, but it's going to grow back." Sprinklers Meanwhile, Mark Paquette is determined to save his cabin. Flames are currently as close as 300 metres to his recreational property on Nemeiben Lake, north of La Ronge. A screen grab of the video of the fire taken from Mark Paquette's dock. (Submitted by Mark Paquette) For the past two weeks, Paquette and his wife have been busy watering down his buildings with industrial-grade sprinklers and clear cutting neighbouring trees. "It's very serious," he said. "[The fire] is basically taking out all the trees that it can, it's so dry up here." Paquette and his wife have been sleeping in shifts, sometimes in their boat, as they wait out the fire, for safety reasons. 'It's very impressive' "When the fire is very close, and it's active, we basically pack everything up, we put it on our boat and we anchor out about 200-300 metres from the shore, depending on wind direction, of course." Paquette has seen the huge fire up close, and said it's very impressive. "All of a sudden you'll hear, it's like the airport, you'll hear a jet sort of sound start up in the forest, followed by a really black smoke," he said. "Then you'll see basically a fireball race across the trees." Despite the danger, Paquette plans to stay at his cabin until it's too dangerous. He was hoping calm weather Wednesday would continue. "Last night was the first night in two weeks where we could sleep somewhat, without being on pins and needles all night," he said. "I don't know if we're in the clear or sleeping on a bed of gasoline." Paquette thanked conservation officers for risking their lives to fight the fires, and for supplying him with fuel for his sprinkler system.Q: How to kill a thread nice in java? A common question but I haven't found any acceptable answer. I recently run in to the problem how to kill a thread in a nice way. I try to make a generic message handler that accepts runnables. The problem is that I can't exit the current runnable in a good way and fast enough. The code in the runnables are unknown i.e. jni, pure java, 3:rd part lib etc. Below is a simple example with sleep that "steels" the interrupt so the thread never exits (fast enough): I wan't to be able to interrupt the thread at any time, only between each task are not acceptable. My first idea was to use thread.stop but that's deprecated. Producer: int i = 0; MessageHandler handler = new MessageHandler(); handler.start(); handler.post(new Runnable() { @Override public void run() { System.out.println("task -" + i++ + " " + Thread.currentThread().getName()); for (int r=0;r<1000000000;r++) { System.out.println("task -" + i++ + " " + Thread.currentThread().getName()); try { Thread.sleep(1000); } catch (InterruptedException e) { e.printStackTrace(); } } } }); try { Thread.sleep(500); } catch (InterruptedException q) { q.printStackTrace(); } handler.interrupt(); Consumer (MessageHandler): package test; import java.util.concurrent.BlockingQueue; import java.util.concurrent.LinkedBlockingQueue; public class MessageHandler extends Thread implements Runnable { private BlockingQueue<Runnable> msgQue = new LinkedBlockingQueue<Runnable>(); private final static String TAG = "MessageHandler"; public void run() { try { System.out.println(TAG + " Initialized " + currentThread().getName()); while(true) { Runnable task = msgQue.take(); task.run(); if (isInterrupted()) { break; } } } catch (InterruptedException e) { System.out.println(TAG + " InterruptedException " + currentThread().getName()); } finally { System.out.println(TAG + " Exit " + currentThread().getName()); msgQue.clear(); msgQue = null; } } public void post(Runnable task) { System.out.println(TAG + " post " + currentThread().getName()); msgQue.add(task); } } I feel like a superman wihout any super power... Hey, Oracle give my power back! A: Check out this faq on why they deprecated Thread.stop() and what to use instead. The gist of it is to use Thread.interrupt(). In the process of refurbishing this old post on the Beatles and piracy, I stumbled across this NME
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,3 Hypoechoic Heterogenous Indistinct Absent 36 F 51 Antrum I Absent Absent Present Absent Absent  5 Intramural 2,3 Hypoechoic Heterogenous Indistinct Present by Yamada classification [@JR1044-6] ; ME-NBI, magnifying endoscopy with narrow-band imaging; EUS, endoscopic ultrasonography; MS, microsurface structure. As shown by EUS, the lesions were mainly located in the second (deep mucosal), third (submucosal), and/or fourth (muscularis propria) layers and ranged from 6 to 25 mm in size (median size: 13 mm) ( [Table 2](#TB1044-2){ref-type="table"} ). All lesions showed mural growth pattern and hypoechoic echogenicity. Thirty-four lesions (34/36, 94 %) were heterogeneous and the borders were indistinct in 32 lesions (32/36, 89 %). Anechoic duct-like structures appeared in 32 lesions (32/36, 89 %). Two lesions involved only one sonographic layer of the gastric wall: the third layer. Twenty-eight lesions involved two sonographic layers: 13 in the second and third layers and 15 in the third and fourth layers. Three lesions involved the second, third, and fourth layers, and three involved the third, fourth, and fifth layers. On the basis of the sonographic layer of origin, 15 of 36 lesions were S-type and the other 21 lesions were D-type. ###### Baseline and endosonographic characteristics of 36 patients with gastric heterotopic pancreas. --------------------------------------- --------------- **Patient characteristics** Median age (years, range) 40 (15 -- 70) Sex, n (%) Male 22 (61) Female 14 (39) **Endoscopic characteristics** Location, n (%) Antrum 30 (83) Lower body  4 (11) Mid-body  2 (6) Macroscopic shape, n (%) Yamada type I 36 (100) Umbilication/dimpling, n (%) Present  6 (17) Absent 30 (83) Opening, n (%) Present  9 (25) Absent 27 (75) **Endosonographic characteristics** Median size (mm, range) 13 (6 -- 25) Growth pattern, n (%) Mural 36 (100) Echogenicity, n (%) Hypoechoic 36 (100) Homogeneity, n (%) Heterogenous 34 (94) Homogenous  2 (6) Border, n (%) Indistinct 32 (89) Distinct  4 (11) Anechoic duct-like structure, n (%) Present 32 (89) Absent  4 (11) Endosonographic classification, n (%) Superficial type 15 (42) Deep type 21 (58) --------------------------------------- --------------- On ME-NBI, a microscopic opening was identified in 22 of 27 lesions (81 %) in which a macroscopic opening was not observed during conventional endoscopy ( [Table 3](#TB1044-3){ref-type="table"} ) ( [Fig. 2](#FI1044-2){ref-type="fig"} ). As a result, macroscopic or microscopic opening was observed in 31 lesions (31/36, 86 %). Of 32 lesions in which anechoic duct-like structures appeared on EUS, 29 lesions had a macroscopic or microscopic opening on ME-NBI. On the contrary, of four lesions in which anechoic duct-like structures did not appear on EUS, two lesions had a macroscopic or microscopic opening. Therefore, frequency of macroscopic or microscopic opening was higher in lesions with anechoic duct-like structures than that in lesions without anechoic duct-like structures on EUS (91 % \[29/32\] vs 50 % \[2/4\], *P*  = 0.027). Of 21 D-type lesions, 19 lesions had a macroscopic or microscopic opening on ME-NBI, and of 15 S-type lesions, 12 lesions had a macroscopic or microscopic opening. No difference was observed in the frequency of macroscopic or microscopic opening between S-type and D-type lesions (80 % \[12/15\] vs 90 % \[19/21\], *P*  = 0.370). In addition, focal loss of microsurface structure and presence of a thickened submucosal vessel were observed in six (6/36, 17 %) and five lesions (5/36, 14 %), respectively. ###### Magnifying endoscopy with narrow-band imaging of gastric heterotopic pancreas. --------------------------------------------- --------- Macroscopic or microscopic opening, n (%) Present 31 (86) Absent  5 (14) Focal loss of microsurface structure, n (%) Present  6 (17) Absent 30 (83) Thickened submucosal vessel, n (%) Present  5 (14) Absent 31 (86) --------------------------------------------- --------- ![ A representative case of heterotopic pancreas (case 31). **a** A subepithelial lesion is seen on the greater curvature of the gastric antrum. **b** On magnifying endoscopy with narrow-band imaging, a microscopic opening is observed on its surface (arrow). **c** Endosonographic image obtained with a 20-MHz catheter probe. A heterogeneously hypoechoic lesion with lobular margins is located within the submucosal layer. Anechoic duct-like structure is observed at its periphery (asterisk).](10-1055-s-0044-101350-i1044ei2){#FI1044-2} Discussion ========== A firm round or oval subepithelial lesion with central dimpling or umbilication, which corresponds to the opening of a duct, is the typical endoscopic finding for heterotopic pancreas [@JR1044-7] . However, it is seen in only about one-third of cases [@JR1044-5] [@JR1044-8] . Therefore, we used ME-NBI to identify any additional data to predict diagnosis of heterotopic pancreas. We found that a microscopic opening was present on ME-NBI in more than 80 % of lesions without a macroscopic opening. To our knowledge, this study is the first to report about ME-NBI for gastric heterotopic pancreas. ME-NBI is a powerful diagnostic modality because it can enable visualization of real-time microscopic images of the mucosal surface [@JR1044-9] , and the most advanced endoscope has a maximal resolution power as small as 6.4 µm [@JR1044-10] . Although the clinical usefulness of ME-NBI has been reported in gastritis and early gastric cancer [@JR1044-11] [@JR1044-12] , reports on use of ME-NBI in gastric subepithelial lesions are few. Histologically, heterotopic pancreas mainly consists of exocrine tissue and excretory ducts. In a case series including 32 cases of heterotopic pancreas in the gastrointestinal tract, all had excretory ducts and 97 % had acini [@JR1044-13] . As previously mentioned, the small ducts mainly drain directly into the gastric lumen. In the current study, a microscopic opening was identified in 22 of 27 heterotopic pancreas lesions without a macroscopic opening. These findings suggest the usefulness of ME-NBI to predict diagnosis of heterotopic pancreas. Is a microscopic opening present only in heterotopic pancreas? Based on our experience, we could detect a microscopic opening in about one-third of gastritis cystica profunda cases (unpublished data). However, because gastritis cystica profunda has a soft consistency due to its inner liquid component (positive pillow sign), it can be easily differentiated from heterotopic pancreas, which has a hard consistency. We also found a focal loss of microsurface structure in six lesions. The focal loss of microsurface is thought to be caused by chronic irritation from enzymes secreted by the heterotopic pancreas. In addition, a thickened submucosal vessel was noted in five lesions. The appearance of this vessel in gastric subepithelial lesions was previously reported in a case of gastric carcinoid tumor [@JR1044-14] . Therefore, we speculate that presence of a thickened submucosal vessel is an indirect sign suggesting that a lesion has subepithelial components, such as endocrine nests in the carcinoid tumor or pancreas acinar nest in the heterotopic pancreas. There remains a paucity of data about ME-NBI findings for gastric subepithelial lesions. Thus, further studies involving a larger series of patients with subepithelial lesions are necessary. Heterotopic pancreas in the stomach is often
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onov-Bohm effect and the one-dimensional Pöschl-Teller system for a generic magnetic flux value case is somewhat of the AdS/CFT holography [@ads1] nature. This observation deserves a deeper study that can be useful in the context of the integrable nonlinear equations. For the peculiar case of half-integer values of the flux, we considered this aspect in the context of non-relativistic AdS/CFT [@NRCFT; @DHH]. Namely, we showed, that the analogs of the free particle generators of the dynamical conformal, $so(2,1)$, and bosonized superconformal, $osp(2|2)$, symmetries can be transferred to the RPT system by the Crum-Darboux transformation. In the case of the conformal $so(2,1)$ dynamical symmetry, there appears a certain nonlinear deformation of the $so(2,1)$ algebra. In the case of the superconformal $osp(2|2)$ symmetry, in addition to a deformation, finite number of new fermionic integrals is generated. These dynamical symmetries of the RPT system need a further investigation. The conformal $so(2,1)$ dynamical symmetry of the planar Aharanov-Bohm effect finds a natural explanation in the AdS/CFT context [@LP1; @DHH]. The bound state Aharonov-Bohm effect, that corresponds to a particle confined to a circle pierced by the Aharonov-Bohm flux, is characterized by the hidden bosonized supersymmetry as well [@PTsusy]. It would be interesting to look for the hidden bosonized $N=2$ supersymmetry and bosonized superconformal $osp(2|2)$ dynamical symmetry in the planar Aharonov-Bohm effect [@CFJP]. Nonlinear bosonized supersymmetry of the RPT system and tri-supersymmetry of the extended RPT system are related to the nontrivial Lax operator which is the higher order differential operator. As we saw, this operator is the first order integral $\frac{d}{dx}$ of the free particle transferred to the RPT system by the Crum-Darboux transformation. Its square gives a spectral polynomial of the RPT system, that has double roots and describes a degenerate hyperelliptic curve [@integrable]. This degeneration originates from the infinite-period limit applied to the finite-gap periodic Lamé, or associated Lamé system. It is this limit that produces the RPT system with its unique, pure imaginary period from the double periodic model. The spectral polynomial of the associated Lamé system is non-degenerate. It was showed in [@trisusy; @trisusy1] that such a finite-gap periodic system is also characterized by the hidden bosonized nonlinear supersymmetry, while the pair of such systems is described by the tri-supersymmetric structure. In the case of the finite-gap periodic systems, Crum-Darboux transformations relate the systems with the same number of gaps. 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, [@B7]). While the complexity issue was already outlined in the Introduction, the following section focuses on the interoperability. Image acquisition, processing and data analysis involves data exchange between heterogeneous hardware and software. This requires maintaining interoperability between multiple, and most often, heterogeneous software packages and hardware devices. Interoperability can be achieved by: (i) adhering to common (i.e., mutually accepted) data exchange formats and communication protocols; or by (ii) direct integration of hardware (resp. software) in acquisition or analysis platforms. On the image acquisition level, the interoperability challenge is being addressed by the project μManager (Edelstein et al., [@B17]). The μManager system facilitates microscope control and image acquisition and aims at the development of open-source software for control of automated microscopes. Drivers for different microscopic components are supported in modular manner thus allowing independent setups to be built. On the image storage level the interoperability is addressed by OME (respectively OMERO) which provides structured storage and data import from a great number of proprietary image file formats. According to Swedlow et al. ([@B50]) the most important recommendations that would help bridge the heterogeneity are that the meta-data should be readable by third party software using a widely accepted package or library and the commercial software programs need to provide data export to an open meta-data specification and the scientists should use image processing and analysis tools that preserve image meta-data. On the image processing level, the challenge is addressed by CellProfiler which allows for the composition of complex processing workflows using a number of third party tools. On the measurement and application level, the interoperability is addressed by *LabIS*. Presented interoperability cases demonstrate the integration of *LabIS* in the experimental workflow on the level of the organization and interpretation of the derived data. Functionality realized in *LabIS* can be used in several directions. In the first place, *LabIS* is a workflow management tool. As such it allows for organization and reporting of the performed experiments. On the second place, *LabIS* can be used as a processed data (i.e., measurements) repository. Using the web-service or the database interfaces, the data can be accessed by computational and statistical environments, such as Matlab and the R-language. On the third place, *LabIS* can be used as a data sharing tool. It allows publication of the raw experimental data with any desired degree of restriction of the details. Such data can be used by other research teams to support collaborations. In contrast to specific atlasing tools, such as the Rodent Brain Workbench[^19^](#fn19){ref-type="fn"} (Moene et al., [@B30]), *LabIS* is much less application-centric. Sharing of the raw data and measurements in neuroscience gains momentum. It is believed that the widespread sharing of data and tools for neuroscientific research will accelerate the development of neuroinformatics (Eckersley et al., [@B16]). The exchange of raw neuroscience data between groups presents the opportunity to differently re-analyze previously collected data and encourage new interpretations (Amari et al., [@B1]). With the increase of experimental complexity and the size restrictions imposed by the scientific publishers, frequently essential experimental details are omitted from the final peer reviewed publications. This would eventually lead to unnecessary reproduction of experiments and waste of time and resources. On the other hand, data sharing can reduce experimental and analytical error. Conflict of Interest Statement ============================== The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. ^1^<http://www.openmicroscopy.org/site> ^2^<http://ccdb.ucsd.edu/index.shtm> ^3^<http://opencv.willowgarage.com/wiki/> ^4^<http://www.bioimage.ucsb.edu/bisque> ^5^<http://www.xnat.org/> ^6^<http://www.geneontology.org> ^7^<http://www.obofoundry.org/cgi-bin/detail.cgi?id=unit> ^8^<http://www.ebi.ac.uk/ols> ^9^<http://obofoundry.org/> ^10^<http://bioportal.bioontology.org/> ^11^<http://www.php.net> ^12^<http://www.mysql.com> ^13^<http://www.apache.org> ^14^<http://sourceforge.net/projects/nusoap> ^15^<http://www.mathworks.com/help/techdoc/ref/createclassfromwsdl.html> ^16^Currently only the Mozilla Firefox web browser's JavaScript engine is fully supported. Internet Explorer is supported as of version 7. While Safari and Chorme browsers are not tested. ^17^[www.zoomify.com](www.zoomify.com) ^18^<http://www.humanconnectomeproject.org/> ^19^<http://rbwb.org/> ![**The main menu of *LabIS***.](fninf-05-00025-a001){#FA1} ![**The projects module**.](fninf-05-00025-a002){#FA2} ![**The Image measurements and morphometry module**.](fninf-05-00025-a003){#FA3} B.1. XML and name-spaces ======================== The Extensible Markup Language (XML) is a general-purpose open standard for creating custom markup documents. It is extensible in the sense that it allows its users to define their own elements using "name-spaces." Its primary purpose is to facilitate sharing of information between information systems. The specification of XML is supported by the World Wide Web Consortium (W3C). The recommendation specifies both the lexical grammar and the requirements for parsing. An XML document may contain element or attribute names from more than one XML vocabulary. The XML name-spaces are controlled vocabularies of the language containing collections of structuring elements which are not part of the original specification but comply to the XML grammar. They are defined by a W3C recommendation called Namespaces in XML. XML Schema, published as a W3C recommendation in May 2001, is one of several XML schema languages. XML Schema is a XML language for data structures (i.e., schemas), prescribed by the W3C as the successor of DTDs. XML Schema can be used to express a schema: a set of rules to which an XML document must conform in order to be considered "valid" according to that schema. B.2. SOAP protocol primer ========================= ![**The SOAP protocol. Interaction between the service consumer and the service provider (top)**. Elements of the SOAP message over HTTP (bottom).](fninf-05-00025-a004){#FA4} B.3. Main functionality of the web-service ========================================== The main operations and functionality of the SOAP binding are summarized in Tables [A1](#TA1){ref-type="table"} and [A2](#TA2){ref-type="table"}. SOAP is a protocol for exchanging XML-based messages over computer networks, normally using HTTP/HTTPS. SOAP once stood for "Simple Object Access Protocol" but this acronym was dropped with Version 1.2 of the standard, as it was considered to be misleading. The primitive data types are defined by the *XMLSchema* `xsd` and `xsi` name-spaces, while the web-service components are defined by the *Web-Service Description Language* WSDL name-space (Christensen et al., [@B55]), which describes the public operations the web-service clients can execute (see Figure [A4](#FA4){ref-type="fig"}). The SOAP protocol is defined by 3 name-spaces: `xmlns:soap`, `xmlns:SOAP-ENV`, and `xmlns:SOAP-ENC` (Table [A1](#TA1){ref-type="table"}). SOAP forms the foundation layer of the web-services providing a basic messaging framework, upon which the application layers was built. The ontology names-space is denoted as `IJMes`. It is an expansion of the SOAP and WSDL name spaces. SOAP forms the foundation layer of the web-services protocol stack providing a basic messaging framework upon which abstract layers can be built. An example of the SOAP message exchange is provided in Listings 1 and 2. The protocol is based on asynchronous exchange of messages. The key features of the SOAP messages are that (i) a SOAP message is a valid XML document, (ii) a SOAP message must use the SOAP Envelope name-space and (iii) a SOAP message must use the SOAP Encoding name-space. Currently the communication patterns of the web-services are described in the terms of the WSDL specification. WSDL is an XML format for describing network services as a set of endpoints operating on messages containing either document-oriented or procedure-oriented information (Christensen et al., [@B56]). The operations and messages are described abstractly, and then bound to a concrete network protocol and message format to define an endpoint (i.e
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7791, 10425, 13057, 15687? -o**2 + 2641*o - 123 What is the m'th term of -688715, -2754846, -6198397, -11019368, -17217759, -24793570, -33746801? -688710*m**2 - m - 4 What is the t'th term of -27599, -27619, -27651, -27695, -27751, -27819, -27899? -6*t**2 - 2*t - 27591 What is the n'th term of 233, 190, 117, 14, -119, -282, -475? -15*n**2 + 2*n + 246 What is the t'th term of 7558, 7569, 7582, 7597, 7614, 7633? t**2 + 8*t + 7549 What is the p'th term of -1006, -935, -862, -787? p**2 + 68*p - 1075 What is the k'th term of -359, -803, -1259, -1733, -2231, -2759, -3323? -k**3 - 437*k + 79 What is the j'th term of 621, 2566, 5823, 10398, 16297, 23526, 32091, 41998? j**3 + 650*j**2 - 12*j - 18 What is the p'th term of -108, -483, -1126, -2037, -3216? -134*p**2 + 27*p - 1 What is the z'th term of 6170, 6163, 6154, 6143, 6130, 6115, 6098? -z**2 - 4*z + 6175 What is the z'th term of 222239, 444479, 666719, 888959, 1111199, 1333439? 222240*z - 1 What is the f'th term of 41046, 82033, 123018, 164001, 204982? -f**2 + 40990*f + 57 What is the y'th term of 2124, 2304, 2484, 2664, 2844, 3024? 180*y + 1944 What is the i'th term of 17959, 36002, 54033, 72046, 90035, 107994, 125917, 143798? -i**3 + 18050*i - 90 What is the a'th term of -61458, -122908, -184352, -245784, -307198, -368588, -429948? a**3 - 3*a**2 - 61448*a - 8 What is the f'th term of 26962, 26963, 26964, 26965? f + 26961 What is the b'th term of 94, 140, 94, -92, -466, -1076? -8*b**3 + 2*b**2 + 96*b + 4 What is the o'th term of 607, 613, 619, 625? 6*o + 601 What is the j'th term of 48602, 97206, 145810, 194414, 243018, 291622? 48604*j - 2 What is the i'th term of 31955, 31941, 31923, 31901, 31875? -2*i**2 - 8*i + 31965 What is the f'th term of 13293, 53190, 119693, 212802, 332517? 13303*f**2 - 12*f + 2 What is the n'th term of -1090541, -1090542, -1090543? -n - 1090540 What is the r'th term of -61455, -61487, -61531, -61593, -61679, -61795? -r**3 - 25*r - 61429 What is the p'th term of 1467, 1474, 1481, 1Olby Out: Al Gore's Current TV has canned it's lead purveyor of left-wing hate speech, Keith Olbermann. Awww. I'll sure miss Olby, even though I haven't watched him since he was on that other left-wing hate speech station, MSNBC (quick MSNBC hate speech example - last night Chris Matthews' show was calling Florida's Stand Your Ground law the "Kill At Will" law, which of course it is not. I don't know how anyone watches that crap). Olby will be replaced by the disgraced former Governor of New York, Eliot Spitzer. You really can't make this stuff up. I assume Malik Zulu Shabazz wasn't available. Escalate: Speaking of MSNBC, former Democratic presidential candidate, riot inciter, race baiter, framer of innocent people, MSNBC talk show host, and lynch mob leader, Al Sharpton, has called for an escalation of civil disobedience if George Zimmerman isn't arrested for the shooting of Trayvon Martin. Sharpton said he will take things to the next "level", all peacefully, of course. Maybe someone should inform Sharpton that the shooting is under investigation at both the state and FBI level, and if the facts warrant it, Zimmerman WILL be arrested. The last time I checked, Al Sharpton was not the American justice system. - A budget based on President Obama's 2013 budget plan was defeated by a unanimous vote of 414-0. Not even one Democrat voted for it. This is a similar outcome to the last Obama budget Congress voted on, over in the Senate in 2011. That one was defeated by a unanimous vote of 97-0. Again, not one Democrat voted with the President. Who says this President can't unite the country ? Because the Obama administration couldn't get Cap And Trade passed through a resistant Congress, it has turned to another legislative branch of the federal government (though we thought there was only supposed to be one), which is known as the Environmental Protection Agency (EPA). The EPA is a curious federal entity. It can make it's own rules, and those rules don't have to be approved by the constitutionally authorized legislative branch. That makes the EPA sort of an Americanized version of the old Soviet Politburo. The consent of the governed is not required. In the following video, Supreme Court Justice Antonin Scalia knocks down the federal government's alleged Commerce Clause case precedents for the ObamaCare individual mandate (and makes the point of my previous post). Scalia also gives the government solicitor a lesson on enumerated powers and the Tenth Amendment. This is music to my ears. The Supreme Court is hearing a case about the ObamaCare mandate this week. Under the mandate, all citizens of the United States will be forced to either purchase government-approved health insurance from private providers or pay a fine. The case is an appeal of an Eleventh Circuit Court decision which held the ObamaCare individual mandate to be unconstitutional under both the Commerce Clause and the Taxing And Spending Clause of the Constitution. That ruling stated the following: The collective over the individual, nationalizing health care, nationalizing banks, confiscating guns, the abolition of God, the government in charge of industry, liberty in chains, all to help the common man, of course... Correction: Before I get into today's subject matter, I want to issue a correction regarding a source I used in a post about voting fraud. In a January 23rd post titled, 'Monday Madness', I cited the South Carolina Attorney General's letter to the U.S. Justice Dept., which stated that 953 dead people voted in a South Carolina election. I used that source to say liberals were lying about occurrences of voting fraud. Liberals have been contending recently that there are very few instances of voting fraud (contrary to what liberals contended in the aftermath of the 2000 and 2004 elections). After a partial investigation of the matter, it turns out the S.C. Attorney General's voting fraud fears may be unfounded: On television last night, I saw both Rick Santorum (R-PA) and Newt Gingrich (R-GA) waving Etch-A-Sketches around onstage, saying Mitt Romney (R-MA) would erase his primary campaign and move left for the general election. This was meant to imply Romney is a flip-flopping politician with no conservative principles, and came after Romney adviser Eric Fehrnstrom went on CNN and compared the general election to an Etch A Sketch, saying Romney can "shake it up" and "start all over again" in the fall. Such is politics, I suppose, but this prompts me to share a few thoughts about the GOP primary race. Normally, I would rather get a root canal than post a clip from Bill Maher's show, but I'm going to make an exception here. The following videos were made by filmmaker Alexandra Pelosi (Nancy Pelosi's daughter). The first part of the video shows some stereotypical rednecks from the deep South being...stereotypical rednecks from the deep South (Stereotype Right). The second part of the video shows stereotypical welfare seekers looking for handouts being...stereotypical welfare seekers looking for handouts (Stereotype Left). Unfortunately
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shortest path distance of 5.656854249492381 */ public static String[] testMaze1 = new String[]{ " ", " X ", " S X G ", " X ", " ", " "}; /** * 20x32 maze with a shortest path distance of 81.69848480983497 */ public static String[] testMaze2 = new String[]{ "XXSXXXXXXXXXXXXXXXXXXXXXXXXXXXXX", "XX XXXXXXXXXXXXX XXXXXXXXXXX", "XX XXXXXXXXXX XXX XX XXXX", "XXXXX XXXXXX XXX XX XXX XXXX", "XXX XX XXXXXX XX XXX XX XX XXXX", "XXX XXXXX XXXXXX XXXXXX XXXX", "XXXXXXX XXXXXX XXXX", "XXXXXXXXXX XXXXX XXXXXXXXXXXXXXX", "XXXXXXXXXX XX XXXXX XXXX", "XXXXXXXXXX XXXXXXXX XXXX XXXX", "XXXXXXXXXXX XXXXXXXXXX XXXX XXXX", "XXXXXXXXXXX XXXX XXXX", "XXXXXXXXXXXXXXXXXXXXXXXX XX XXXX", "XXXXXX XXXX XX XXXX", "XXXXXX XXXXXXXXXXXX XX XXXX", "XXXXXX XXG XXXXXX XXXX XXXXXXX", "XXXXXX XXXXX XXX XX", "XXXXXX XXXXXXX XXXXXXXXXXX XXXXX", "XXXXXX XXXXXXX XXXXXXXXXXXXXXXXX", "XXXXXX XXXXXXXXXXXXXX"}; /** * 13x33 maze with a shortest path distance of 15.55634918610405 */ public static String[] testMaze3 = new String[]{ " G ", " ", " ", " ", " ", " ", " ", " ", " ", " ", " ", " S ", " "}; /** * 13x33 maze with a shortest path distance of 27.07106781186548 */ public static String[] testMaze4 = new String[]{ " G ", " ", " ", " ", " ", " XXXXXXXXXXXXXXXXXXXXX ", " XXXXXXXXXXXXXXXXXXXXX ", " XXX ", " XXX ", " XXX ", " XXX ", " S ", " "}; /** * 13x33 maze with a shortest path distance of 34.14213562373095 */ public static String[] testMaze5 = new String[]{ " X G ", " X ", " XXXXXXXX ", " XXXXXXXXXX XXXXX ", " X XXXXXXXXXX ", " XXXXXX XXXXXXX XXXX ", " XXXXXX XXXXXXX XXXXX ", " XXX ", " XXX ", " XXX ", " XXX ", " S ", " "}; public static String[] exampleMaze1 = new String[]{ "| _________ |", "| | | |", "| | G |", "| |_______| |", "| |", "| ||_____________________|| ||___|| ||_ |", "| || |", "| //___________ ____________ _______ |", "| // // // // |", "| // // |", "| // // |", "| // // |", "| |", "| |", "| S |", "| |" }; /** * ASCII Maze examples with the shortest path distance. */ public enum TestMaze { MAZE1(new Maze2D(testMaze1),5.656854249492381), MAZE2(new Maze2D(testMaze2),81.69848480983497), MAZE3(new Maze2D(testMaze3),15.55634918610405), MAZE4(new Maze2D(testMaze4),27.07106781186548), MAZE5(new Maze2D(testMaze5),34.14213562373095); double minimalPathCost; Maze2D maze; TestMaze(Maze2D maze, double minimalPathCost){ this.maze = maze; this.minimalPathCost = minimalPathCost; } public double getMinimalPathCost() { return minimalPathCost; } public Maze2D getMaze() { return maze; } } } Allergenicity and cross-reactivity of Russian olive pollen (Eleagnus angustifolia). The purposes of this study were: to determine the prevalence of sensitization and immunochemical characterization of Eleagnus angustifolia pollen (Russian olive) that belongs to the family Eleagnaceae. A total of 134 patients with rhinoconjunctivitis and/or asthma were studied. Its allergenicity, cross-reactivity with olive pollen and the presence of Ole e 1 and Ole e 4-like molecules were evaluated. Eleagnus angustifolia pollen was detected from May to June. Seventy-three of 134 (30.5%) had positive skin test to E. angustifolia, all of them were positive to olive. There was a good correlation between specific immunoglobulin (Ig)E levels to E. angustifolia and Olea europaea (r = 0.77, P = 0.002). Sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) immunoblots revealed major IgE-binding bands in the E. angustifolia extract of 43 and 63.7 kDa. The E. angustifolia extract was not able to inhibit olive, whereas O. europaea inhibited E. angustifolia up to 41%. The presence of Ole e 1- and Ole e 4-like allergens in E. angustifolia extract was confirmed by enzyme-linked immunosorbent (ELISA) inhibition assays. Nasal challenge with E. angustifolia was positive in three of six patients with positive skin test to both pollens and negative in five patients with positive skin test only to O. europaea. This study confirms that E. angustifolia is capable of sensitizing individuals in Madrid. A minimal-to-moderate cross-reactivity with olive pollen was established, suggesting some cross-reactivity but not excluding co-sensitization.Point Loma Office Our Point Loma office is represented by some of the best agents in the business, all of whom are specialized and experienced working in the Point Loma and surrounding real estate markets. If you are in the neighborhood, please come in and see us.Quercetin‑3‑methyl ether suppresses human breast cancer stem cell formation by inhibiting the Notch1 and PI3K/Akt signaling pathways. Breast cancer is a leading cause of mortality among women with cancer worldwide. Quercetin‑3‑methyl ether, a natural compound occurring in various plants, has been indicated to have potent anticancer activity. Breast cancer cell growth and survival were examined by CCK‑8 and colony formation assay, whilst cell cycle and apoptosis were determined by flow cytometry. Cell invasion and migration were assessed by wound‑healing assay and Transwell assay. Cancer stem cell formation was analyzed by mammosphere formation assay and related signaling pathways were detected by western blotting. In the present study, it was observed that treatment with quercetin‑3‑methyl ether significantly inhibited cell growth, induced apoptosis and cell cycle arrest at the G2‑M phase, and suppressed invasion and migration in human breast cancer cells, including the triple negative MDAMB‑231 cell line, and the estrogen receptor‑positive/progesterone receptor‑positive/human epidermal growth factor receptor 2‑negative MCF‑7 and T47D cell lines. This compound also markedly suppressed the epithelial‑mesenchymal transition process as evidenced by the upregulated expression of E‑cadherin, and the concomitant downregulated expression of vimentin and MMP‑2. Furthermore, it was demonstrated that quercetin‑3‑methyl ether treatment inhibited mammosphere formation and the expression of the stemness‑related genes, SRY‑box 2 and Nanog. Mechanistically, this compound decreased the expression of Notch1, and induced the phosphorylation of phosphoinositide 3‑kinase (PI3K) and Akt. It also attenuated the human insulin growth factor 1‑induced phosphorylation of
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ator) \ (current.allocator > previous.allocator \ ? current.allocator - previous.allocator \ : 0) static void RecordPurgeAndSuspendMemoryGrowthKB(const char* basename, const char* suffix, int memory_usage) { std::string histogram_name = base::StringPrintf("%s.%s", basename, suffix); base::UmaHistogramMemoryKB(histogram_name, memory_usage); } void RenderThreadImpl::RecordPurgeAndSuspendMemoryGrowthMetrics( const char* suffix, int foregrounded_count_when_purged) { // If this renderer is resumed, we should not update UMA. if (!RendererIsHidden()) return; if (foregrounded_count_when_purged != process_foregrounded_count_) return; RendererMemoryMetrics memory_metrics; if (!GetRendererMemoryMetrics(&memory_metrics)) return; RecordPurgeAndSuspendMemoryGrowthKB( "PurgeAndSuspend.Experimental.MemoryGrowth.PartitionAllocKB", suffix, GET_MEMORY_GROWTH(memory_metrics, purge_and_suspend_memory_metrics_, partition_alloc_kb)); RecordPurgeAndSuspendMemoryGrowthKB( "PurgeAndSuspend.Experimental.MemoryGrowth.BlinkGCKB", suffix, GET_MEMORY_GROWTH(memory_metrics, purge_and_suspend_memory_metrics_, blink_gc_kb)); RecordPurgeAndSuspendMemoryGrowthKB( "PurgeAndSuspend.Experimental.MemoryGrowth.MallocKB", suffix, GET_MEMORY_GROWTH(memory_metrics, purge_and_suspend_memory_metrics_, malloc_mb) * 1024); RecordPurgeAndSuspendMemoryGrowthKB( "PurgeAndSuspend.Experimental.MemoryGrowth.DiscardableKB", suffix, GET_MEMORY_GROWTH(memory_metrics, purge_and_suspend_memory_metrics_, discardable_kb)); RecordPurgeAndSuspendMemoryGrowthKB( "PurgeAndSuspend.Experimental.MemoryGrowth.V8MainThreadIsolateKB", suffix, GET_MEMORY_GROWTH(memory_metrics, purge_and_suspend_memory_metrics_, v8_main_thread_isolate_mb) * 1024); RecordPurgeAndSuspendMemoryGrowthKB( "PurgeAndSuspend.Experimental.MemoryGrowth.TotalAllocatedKB", suffix, GET_MEMORY_GROWTH(memory_metrics, purge_and_suspend_memory_metrics_, total_allocated_mb) * 1024); } void RenderThreadImpl::CompositingModeFallbackToSoftware() { gpu_->LoseChannel(); is_gpu_compositing_disabled_ = true; } scoped_refptr<gpu::GpuChannelHost> RenderThreadImpl::EstablishGpuChannelSync() { TRACE_EVENT0("gpu", "RenderThreadImpl::EstablishGpuChannelSync"); scoped_refptr<gpu::GpuChannelHost> gpu_channel = gpu_->EstablishGpuChannelSync(); if (gpu_channel) GetContentClient()->SetGpuInfo(gpu_channel->gpu_info()); return gpu_channel; } void RenderThreadImpl::RequestNewLayerTreeFrameSink( int routing_id, scoped_refptr<FrameSwapMessageQueue> frame_swap_message_queue, const GURL& url, const LayerTreeFrameSinkCallback& callback, mojom::RenderFrameMetadataObserverClientRequest render_frame_metadata_observer_client_request, mojom::RenderFrameMetadataObserverPtr render_frame_metadata_observer_ptr) { // Misconfigured bots (eg. crbug.com/780757) could run layout tests on a // machine where gpu compositing doesn't work. Don't crash in that case. if (layout_test_mode() && is_gpu_compositing_disabled_) { LOG(FATAL) << "Layout tests require gpu compositing, but it is disabled."; return; } const base::CommandLine& command_line = *base::CommandLine::ForCurrentProcess(); viz::ClientLayerTreeFrameSink::InitParams params; params.compositor_task_runner = compositor_task_runner_; params.enable_surface_synchronization = features::IsSurfaceSynchronizationEnabled(); params.local_surface_id_provider = std::make_unique<RendererLocalSurfaceIdProvider>(); if (features::IsVizHitTestingDrawQuadEnabled()) { params.hit_test_data_provider = std::make_unique<viz::HitTestDataProviderDrawQuad>( true /* should_ask_for_child_region */); } // The renderer runs animations and layout for animate_only BeginFrames. params.wants_animate_only_begin_frames = true; // In disable frame rate limit mode, also let the renderer tick as fast as it // can. The top level begin frame source will also be running as a back to // back begin frame source, but using a synthetic begin frame source here // reduces latency when in this mode (at least for frames starting--it // potentially increases it for input on the other hand.) if (command_line.HasSwitch(switches::kDisableFrameRateLimit)) params.synthetic_begin_frame_source = CreateSyntheticBeginFrameSource(); #if defined(USE_AURA) if (base::FeatureList::IsEnabled(features::kMash)) { if (!RendererWindowTreeClient::Get(routing_id)) { callback.Run(nullptr); return; } scoped_refptr<gpu::GpuChannelHost> channel = EstablishGpuChannelSync(); // If the channel could not be established correctly, then return null. This // would cause the compositor to wait and try again at a later time. if (!channel) { callback.Run(nullptr); return; } RendererWindowTreeClient::Get(routing_id) ->RequestLayerTreeFrameSink( gpu_->CreateContextProvider(std::move(channel)), GetGpuMemoryBufferManager(), callback); frame_sink_provider_->RegisterRenderFrameMetadataObserver( routing_id, std::move(render_frame_metadata_observer_client_request), std::move(render_frame_metadata_observer_ptr)); return; } #endif viz::mojom::CompositorFrameSinkRequest compositor_frame_sink_request = mojo::MakeRequest(&params.pipes.compositor_frame_sink_info); viz::mojom::CompositorFrameSinkClientPtr compositor_frame_sink_client; params.pipes.client_request = mojo::MakeRequest(&compositor_frame_sink_client); if (is_gpu_compositing_disabled_) { DCHECK(!layout_test_mode()); frame_sink_provider_->CreateForWidget( routing_id, std::move(compositor_frame_sink_request), std::move(compositor_frame_sink_client)); frame_sink_provider_->RegisterRenderFrameMetadataObserver( routing_id, std::move(render_frame_metadata_observer_client_request), std::move(render_frame_metadata_observer_ptr)); callback.Run(std::make_unique<viz::ClientLayerTreeFrameSink>( nullptr, nullptr, &params)); return; } scoped_refptr<gpu::GpuChannelHost> gpu_channel_host = EstablishGpuChannelSync(); if (!gpu_channel_host) { // Wait and try again. We may hear that the compositing mode has switched // to software in the meantime. callback.Run(nullptr); return; } scoped_refptr<viz::RasterContextProvider> worker_context_provider = Shared