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23์ธ ์ฌ์ฑ ํ์๊ฐ ๊ฐ์์ค๋ฌ์ด ํธํก ๊ณค๋๊ณผ ํ๋ง์ฑ ํํต์ด ๋ฐ์ํ ์ง 8์๊ฐ ํ์ ์๊ธ์ค๋ก ์ด์ก๋์๋ค. ํ์๋ ๋ญ์ฑ ์ฌ์ ์ฆ์ ์๊ณ ์์ผ๋ฉฐ, ์ง๋ 1๋
๋์ 4๋ฒ์ ํธํก๊ธฐ ์
ํ๋ก ์
์ ์น๋ฃ๋ฅผ ๋ฐ์๋ค. ํ์ฌ ํฌ์ฝ ์ค์ธ ์ฝ๋ฌผ์ ํก์
๊ธฐ๊ด์ง ํ์ฅ์ , ํก์
์ฝ๋ฅดํฐ์ฝ์คํ
๋ก์ด๋, ํก์
N-์์ธํธ์์คํ
์ธ, ์์งํธ๋ก๋ง์ด์ ์ด๋ค. ํ์๋ ๋ง์ฑ์ ์ผ๋ก ์ ์ฝํด ๋ณด์ธ๋ค. ์ฒด์จ์ 37.9ยฐC (100.2ยฐF), ๋งฅ๋ฐ์ 96/min, ํธํก์ 22/min์ด๋ฉฐ ํธํก ๊ณค๋์ด ์๊ณ , ํ์์ 106/64 mm Hg์ด๋ค. ๋น๊ฐ ์บ๋ผ๋ผ๋ฅผ ํตํด 2 L/min์ ์ฐ์๋ฅผ ํฌ์ฌํ ์ํ์์ ๋งฅ๋ฐ ์ฐ์ ์ธก์ ๊ฒฐ๊ณผ ์ฐ์ ํฌํ๋๋ 96%์ด๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ์ ํ ํ๋ถ ์ง๊ฒฝ์ด ์ฆ๊ฐํ๋ค. ์๊ฐ๋ฝ ๊ณค๋ด์ฆ์ด ๊ด์ฐฐ๋๋ค. ํ๋ถ ์ด๋๊ณผ ์ด์ง ์ง๋์ด ์ค๋ฅธ์ชฝ์์ ๊ฐ์ํ๋ค. ํ๋ถ ์ฒญ์ง ์, ์ค๋ฅธ์ชฝ ํ ์์ญ์์ ํธํก์์ด ํ์ ํ๊ฒ ๊ฐ์ํ๊ณ , ์ผ์ชฝ ํ ์์ญ์์ ๊ด๋ฒ์ํ ์ฒ๋ช
์ด ๋ค๋ฆฐ๋ค. ๋ค์ ์ค ์ด ํ์์ ํ์ฌ ์ฆ์์ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ๊ทผ๋ณธ ์์ธ์ ๋ฌด์์ธ๊ฐ? | Apical subpleural cyst | {
"A": "๊ธฐ๊ด์ง ๊ณผ๋ฏผ ๋ฐ์",
"B": "๊ทธ๋ ์์ฑ ๊ตฌ๊ท -๊ฐ๊ท ๊ฐ์ผ",
"C": "ํ์ฒจ๋ถ ๋๋งํ ๋ญ์ข
",
"D": "ํ ๋ชจ์ธํ๊ด ํฌ๊ณผ์ฑ ์ฆ๊ฐ"
} | step2&3 | C | [
"23 year old woman",
"brought",
"emergency department 8 hours",
"sudden onset of shortness",
"breath",
"pleuritic chest pain",
"cystic fibrosis",
"past year",
"4 respiratory exacerbations",
"required hospitalization",
"Current medications include",
"inhaled bronchodilator",
"inhaled corticosteroid",
"inhaled",
"acetylcysteine",
"azithromycin",
"patient appears chronically ill",
"temperature",
"100",
"pulse",
"96 min",
"respirations",
"min",
"labored",
"blood pressure",
"64 mm Hg",
"Pulse oximetry",
"L/min",
"oxygen",
"nasal cannula shows",
"oxygen saturation",
"96",
"Examination shows",
"increased",
"chest diameter",
"digital clubbing",
"Chest",
"tactile fremitus",
"decreased",
"right side",
"auscultation",
"chest",
"breath sounds",
"diminished",
"right lung field",
"diffuse wheezing",
"heard",
"left lung field",
"following",
"most likely underlying cause",
"patient's current symptoms"
] | 00000000000000000201 |
61์ธ์ ๋น๋จ๋ณ ์ฌ์ฑ ํ์๊ฐ ์ง๋ 24์๊ฐ ๋์ ์ฌ๋ฌ ์ฐจ๋ก ๋ณตํต์ ํธ์ํ๋ฉฐ ์๊ธ์ค๋ก ์ด์ก๋์์ต๋๋ค. ํ์๋ ํต์ฆ์ด ๋ํ๊ณ ์ค์๋ ๋ฏํ ์ฑ๊ฒฉ์ด๋ฉฐ, ๋ฑ์ชฝ์ผ๋ก ๋ฐฉ์ฌ๋๊ณ , ์์ฌ ํ ์
ํ๋๋ค๊ณ ๋งํฉ๋๋ค. ๋ํ ๋ฉ์ค๊บผ์๊ณผ ๊ฐํ์ ์ธ ๊ตฌํ ๋ฅผ ํธ์ํฉ๋๋ค. ๊ณผ๊ฑฐ์๋ ์ ์ฌํ ์ฆ์์ผ๋ก ๋ฐ๋ณต์ ์ผ๋ก ์
์ํ ์ ์ด ์์ต๋๋ค. ์ฒด์จ์ 37ยฐ C (98.6ยฐ F), ํธํก์๋ 16ํ/๋ถ, ๋งฅ๋ฐ์ 77ํ/๋ถ, ํ์์ 120/89 mm Hg์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ๊ฒจ๋๋์ด ํผ๋ถ์ ์ด๋์ด ๊ณผ์์์นจ์ฐฉ์ด ๊ด์ฐฐ๋ฉ๋๋ค. ์ง๋๋ฌ ํ์ก ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค.
Glycated hemoglobin (HbA1c): 9.1%
Triglyceride: 675 mg/dL
LDL-Cholesterol: 102 mg/dL
HDL-Cholesterol: 35 mg/dL
Total Cholesterol: 250 mg/dL
Serum Creatinine: 1.2 mg/dL
BUN: 12 mg/dL
Alkaline phosphatase: 100 U/L
Alanine aminotransferase: 36 U/L
Aspartate aminotransferase: 28 U/L
์ด ๊ฒฝ์ฐ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ง๋จ์ ๋ฌด์์
๋๊น? | Pancreatitis | {
"A": "Cholecystitis",
"B": "Choledocholithiasis",
"C": "Pancreatitis",
"D": "Duodenal peptic ulcer"
} | step2&3 | C | [
"61 year old diabetic woman",
"brought",
"emergency department",
"complaint",
"multiple bouts",
"abdominal pain",
"last 24 hours",
"pain",
"dull aching",
"nature",
"radiates",
"back",
"worsens",
"meals",
"nausea",
"occasional vomiting",
"hospitalized repeatedly",
"past",
"similar complaints",
"temperature",
"98",
"F",
"respiratory rate",
"min",
"pulse",
"min",
"blood pressure",
"mm Hg",
"physical exam",
"dark hyperpigmentation of the axillary skin",
"noted",
"blood test report",
"month",
"given",
"Glycated hemoglobin",
"Triglyceride",
"675 mg/dL LDL-Cholesterol",
"mg/dL HDL-Cholesterol",
"35 mg/dL Total Cholesterol",
"mg dL Serum Creatinine",
"1.2 mg dL BUN",
"mg/dL Alkaline phosphatase",
"100 U/L Alanine aminotransferase",
"36 U/L Aspartate aminotransferase",
"U/L",
"most diagnosis",
"case"
] | 00000000000000000202 |
82์ธ ์ฌ์ฑ ํ์๊ฐ ์ค๋ฅธ์ชฝ ๋ค๋ฆฌ์ ์ต์ฑ ๊ดด์ ๋ก ์ธํด ์
์ํ์ต๋๋ค. ์
์ ์ดํ ํ, ๊ทธ๋
๋ ์ ์ ๋ ํผ๋์ค๋ฌ์์ง๊ณ ๋นํธํก์ด ๋ํ๋ฌ์ต๋๋ค. ๊ธฐ๊ด ์ฝ๊ด์ ์ํํ๊ณ ์ธ๊ณต ํธํก ๋ณด์กฐ๋ฅผ ์์ํ์ต๋๋ค. ๊ทธ๋
์ ์ฒด์จ์ 39.6ยฐC (102.5ยฐF)์ด๊ณ , ๋งฅ๋ฐ์ 127/min์ด๋ฉฐ, ํ์์ 83/47 mm Hg์
๋๋ค. ์ธ๊ณต ํธํก๊ธฐ๋ FiO2 100% ๋ฐ ํธํก๋ฅ 20/min์ผ๋ก ์ค์ ๋์์ต๋๋ค. ๊ธฐ๊ด ์ฝ๊ด 30๋ถ ํ์ ํ์ธํ ๋๋งฅํ ๊ฐ์ค ๊ฒ์ฌ ๊ฒฐ๊ณผ PCO2๋ 41 mm Hg์ด๊ณ PO2๋ 55 mm Hg์์ต๋๋ค. ์ ์ ํ ์น๋ฃ์๋ ๋ถ๊ตฌํ๊ณ , ํ์๋ ํธํก ๋ถ์ ์ผ๋ก ์ฌ๋งํ์ต๋๋ค. ์ด ํ์์ ๋ํ ์ถ๊ฐ ํ๊ฐ๋ ๋ค์ ์๊ฒฌ ์ค ๋ฌด์์ ๊ฐ์ฅ ์ ๋ํ๋ผ ๊ฐ๋ฅ์ฑ์ด ์์ต๋๊น? | Fluid in the alveolar space | {
"A": "ํ ๊ณผํฝ์ฐฝ",
"B": "ํ ํ๊ด ๋ด ์์ ์ฆ",
"C": "ํ ์ค์ง ๋ด ๋์",
"D": "ํํฌ ๊ณต๊ฐ ๋ด ์ฒด์ก"
} | step1 | D | [
"year old woman",
"admitted",
"hospital",
"of wet gangrene",
"right leg",
"Two days",
"admission",
"confused",
"tachypneic",
"intubated",
"support",
"initiated",
"temperature",
"pulse",
"min",
"blood pressure",
"83",
"mm Hg",
"ventilator",
"set",
"FiO2",
"100",
"respiratory rate",
"20 min",
"arterial blood gas checked 30 minutes",
"intubation shows",
"PCO2",
"mm Hg",
"PO2",
"55 mm Hg",
"appropriate care",
"patient dies",
"respiratory",
"Further evaluation",
"most likely to show",
"following findings"
] | 00000000000000000203 |
57์ธ์ ํ ๊ฝ์ง ์ฃผ์ธ์ด ๊ฐ์กฑ ์ฃผ์น์์๊ฒ ์ค๋ฅธ์ชฝ ์๊ณผ ํ๋์ ๊ฒฐ์ ์ฑ ๋ณ๋ณ์ ๋ณด์ด๋ฉฐ ๋ด์ํ์ต๋๋ค. ๊ทธ๋ ์ค๋ฅธ์ชฝ "๊ฒ์ง"์ ์ฅ๋ฏธ ๊ฐ์์ ์ฐ๋ ค ์ฒ์ ๋ณ๋ณ์ด ๋ํ๋ฌ๊ณ , ๊ทธ ํ ๋ค๋ฅธ ๋ณ๋ณ๋ค์ด ์๋ก ์ฌ๋ผ๊ฐ๋ ๋ฐฉ์์ผ๋ก ๋ํ๋ฌ๋ค๊ณ ์ค๋ช
ํฉ๋๋ค. ์ฃผ์น์๋ ์ฝ๋ฌผ์ ์ฒ๋ฐฉํ๊ณ ์ฅ๊ธฐ๊ฐ ๋ณต์ฉ ์ ์ฌ์ฑํ ์ ๋ฐฉ์ฆ์ ๋ถ์์ฉ์ผ๋ก ๊ฒฝ๊ณ ํ์ต๋๋ค. ๋ค์ ์ค ์ด ์ฝ๋ฌผ์ ์์ฉ ๊ธฐ์ ์ ๋ฌด์์
๋๊น? | Inhibits ergosterol synthesis | {
"A": "์๋ฅด๊ณ ์คํ
๋กค ํฉ์ฑ์ ์ต์ ํ๋ค",
"B": "์๋ฅด๊ณ ์คํ
๋กค์ ๊ฒฐํฉํ์ฌ ์ธํฌ๋ง์ ํ๊ดด์ ์ธ ๊ธฐ๊ณต์ ํ์ฑํ๋ค",
"C": "๋ฒ ํ ๊ธ๋ฃจ์นธ ํ์ฑ์ ์ต์ ํ๋ค",
"D": "๋ฏธ์ธ ์๊ด ๊ธฐ๋ฅ์ ํ๊ดดํ๋ค"
} | step1 | A | [
"57 year old florist presents",
"family physician",
"nodular lesions",
"right hand",
"forearm",
"got pricked",
"rose thorn",
"right",
"pointer finger",
"first lesions appeared",
"lesions then began to appear",
"ascending",
"physician prescribed",
"medication",
"warned",
"gynecomastia",
"side effect",
"taken",
"long periods",
"time",
"following",
"mechanism of action",
"medication"
] | 00000000000000000204 |
58์ธ ์ฌ์ฑ ํ์๊ฐ ์ง ์ถํ์ ์ฃผ์๋ก ์์ฌ ์ง๋ฃ์ค์ ๋ด์ํ์๋ค. ์ถํ์ ๊ฒฝ๋ฏธํ ์ถํ๋ก ์์๋์ด ์ง๋ ํ ๋ฌ ๋์ ์ฆ๊ฐํ์ฌ ์ง์์ ์ผ๋ก ๋ํ๋๊ณ ์๋ค. ํ์๋ G3P1์ด๋ฉฐ, ๋ค๋ญ์ฑ ๋์ ์ฆํ๊ตฐ๊ณผ ์ 2ํ ๋น๋จ๋ณ ๋ณ๋ ฅ์ด ์๋ค. 4๋
์ ์ ํ๊ฒฝ์ ์๋ฃํ๋ค. ํ๊ฒฝ ์ด๊ธฐ์ 1๋
๋์ ์ฃผ๊ธฐ์ ์์คํธ๋ก๊ฒ-ํ๋ก๊ฒ์คํ
๋ก ํธ๋ฅด๋ชฌ ๋์ฒด ์๋ฒ์ ๋ฐ์๋ค. ์ฒด์ค์ 89 kg (196 lb), ํค๋ 157 cm (5 ft 2 in)์ด๋ค. ํ๋ ฅ ์งํ๋ ๋ค์๊ณผ ๊ฐ๋ค: ํ์ 135/70 mm Hg, ์ฌ๋ฐ์ 78/min, ํธํก์ 12/min, ์ฒด์จ 36.7โ (98.1โ). ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ํน์ด ์ฌํญ์ ์๋ค. ๊ฒฝ์ง ์ด์ํ ๊ฒ์ฌ์์ ์๊ถ ๋ด๋ง ๋๊ป๋ 6 mm๋ก ๋ํ๋ฌ๋ค. ์ง๊ฒฝ ๊ฒ์ฌ์์ ๊ตญ์ ๋ณ๋ณ์ด ์๋ ์๊ถ ๊ฒฝ๋ถ๊ฐ ํ์ธ๋์์ผ๋ฉฐ, ํ์ฅ๋์ง ์์ ์ธ๋ถ ์๊ถ๊ตฌ์์ ํ์ฑ ๋ถ๋น๋ฌผ์ด ๊ด์ฐฐ๋์๋ค. ๊ณจ๋ฐ ๊ฒ์ฌ์์ ์๊ถ์ ์ฝ๊ฐ ๋น๋ํด์ ธ ์์ผ๋ฉฐ, ๊ฐ๋์ฑ์ด ์๊ณ ์ํต์ ์๋ค. ๋ถ์๊ธฐ๋ ์ด์ง๋์ง ์๋๋ค. ์ด ํ์์ ๊ด๋ฆฌ์ ์์ด ๋ค์์ผ๋ก ์ ์ ํ ๋จ๊ณ๋ ๋ฌด์์ธ๊ฐ? | Endometrial biopsy | {
"A": "์๊ถ๊ฒฝ ๊ฒ์ฌ ๋ฐ ์๊ถ ๋ด๋ง ์ํ์ ",
"B": "์๊ถ ๋ด๋ง ์๊ฒ",
"C": "์๋ฆฌ์์ผ์ ์ฃผ์
์ด์ํ ๊ฒ์ฌ",
"D": "ํ์ ์๊ฒ์ ๋๋ฐํ ์๊ถ๊ฒฝ ๊ฒ์ฌ"
} | step2&3 | B | [
"58 year old woman presents",
"physicians office",
"vaginal bleeding",
"bleeding started",
"spotting",
"increased",
"persistent",
"month",
"patient",
"history",
"polycystic ovary syndrome",
"type 2 diabetes mellitus",
"completed menopause",
"years",
"took cyclic estrogen progesterone replacement therapy",
"year",
"beginning",
"menopause",
"weight",
"kg",
"height",
"5 ft 2",
"vital signs",
"follows",
"blood pressure",
"70 mm Hg",
"heart rate",
"min",
"respiratory rate",
"min",
"temperature 36",
"98",
"Physical examination",
"unremarkable",
"Transvaginal ultrasound reveals",
"endometrium of",
"mm thickness",
"Speculum examination shows",
"cervix",
"focal lesions",
"bloody discharge",
"non dilated external os",
"pelvic examination",
"uterus",
"slightly enlarged",
"movable",
"non-tender",
"Adnexa",
"non-palpable",
"next appropriate step",
"management",
"patient"
] | 00000000000000000205 |
ํ ํ์์ด ์ฉ๋-๋ฐ์ ๊ณก์ ์ ๋ํ๋ผ ์ ์๋ ๋ค์ํ ํจ๊ณผ๋ฅผ ๊ฒํ ํ๊ณ ์์ต๋๋ค. ๊ทธ๋ ํน์ ์ฝ๋ฌผ์ด ํน์ ๋ถ์์์ ํจ๋ฅ์ ๋ฐ ๊ธธํญ์ ์ญํ ์ ํ ์ ์์์ ๊ด์ฐฐํ์ต๋๋ค. ๊ทธ๋ ํน์ ๊ทธ๋ํ(์๋ ๊ทธ๋ฆผ ์ฐธ์กฐ)๋ฅผ ๊ทธ๋ฆฌ๊ณ ๋์ผํ ๊ทธ๋ํ์์ ์ธก์ ํ ์ ์๋ ๋ค๋ฅธ ๋ฐ์์ ํ์ธํ๊ณ ์์ต๋๋ค. ๊ทธ๋ ์ฝ๋ฌผ B๊ฐ ์ฝ๋ฌผ A๋ณด๋ค ํจ๋ฅ์ด ๋ฎ๋ค๋ ๊ฒ์ ์๊ฒ ๋์์ต๋๋ค. ์ฝ๋ฌผ B๋ ๋ํ ๋์ผํ ์ฉ์ก์์ ๊ฒฐํฉ๋ ๋ ์ฝ๋ฌผ A์ ํจ๋ฅ์ ๊ฐ์์ํต๋๋ค. ๊ทธ๋ฌ๋ ์ฉ์ก์ ์ฝ๋ฌผ A๋ฅผ ์ถ๊ฐํ๋ฉด ์ฝ๋ฌผ A์ ์ต๋ ํจ๋ฅ(Emax)์ด ์ฆ๊ฐํฉ๋๋ค. ๊ทธ๋ ์ฝ๋ฌผ C์ ๋ํ ๋ ๋ค๋ฅธ ๊ณก์ ์ ๊ทธ๋ฆฌ๊ณ ์ถ์ดํฉ๋๋ค. ๊ทธ๋ ์ฝ๋ฌผ C๊ฐ ์ฝ๋ฌผ A ๋ฐ B์ ๋์ผํ ๋ถ์์ ์์ฉํ์ง๋ง ์ฝ๋ฌผ C๋ ์ฝ๋ฌผ A์ ๊ฒฐํฉ๋ ๋ ์ฝ๋ฌผ A์ ์ต๋ ํจ๋ฅ(Emax)์ ํฌ๊ฒ ๊ฐ์์ํจ๋ค๋ ๊ฒ์ ์๊ฒ ๋ฉ๋๋ค. ๋ค์ ์ค ์ฝ๋ฌผ C๋ฅผ ๊ฐ์ฅ ์ ์ค๋ช
ํ๋ ๊ฒ์ ๋ฌด์์
๋๊น? | Non-competitive antagonist | {
"A": "Competitive antagonist",
"B": "Non-competitive antagonist",
"C": "Inverse agonist",
"D": "Reversible antagonist"
} | step1 | B | [
"student",
"reviewing",
"various effects",
"dose-response curve",
"observed",
"certain drugs",
"work",
"agonist",
"antagonist",
"site",
"graph",
"shown",
"checking",
"responses",
"measured",
"same graph",
"learned",
"drug",
"less potent than drug",
"Drug",
"potency",
"drug",
"combined",
"same solution",
"additional drug",
"added",
"solution",
"maximal efficacy",
"drug",
"increases",
"wishes to",
"curve",
"drug",
"learns",
"drug",
"works",
"same molecules",
"drugs",
"drug",
"maximal efficacy",
"drug",
"combined",
"drug",
"following best",
"drug"
] | 00000000000000000206 |
๊ทํ๋ ํ๋์ฑ ๊ฒฐํต ์น๋ฃ๋ฅผ ์ต๊ทผ ์์ํ ํ์๋ฅผ ์ง๋ฃ์ค์์ ์ง์ฐฐํ๊ณ ์์ต๋๋ค. ํ์ฌ ํ์๋ ๋ฆฌํํ, ์์ด์๋์์ง๋, ํผ๋ผ์ง์๋ฏธ๋ ๋ฐ ์ํ๋ถํจ๋ก ์น๋ฃ๋ฅผ ๋ฐ๊ณ ์์ต๋๋ค. ํ์๋ ์ฝ ๋ณต์ฉ์ ์ต์ํ์ง ์์ ๋ถ์์ฉ์ ๋ํด ๋งค์ฐ ์ฐ๋ คํ๊ณ ์์ต๋๋ค. ํนํ ํ์ํ๋ฌผ ์คํฉ ์ต์ ์ฝ๋ฌผ๊ณผ ๊ด๋ จํ์ฌ, ๋ค์ ์ค ์๋ ค์ง ๋ถ์์ฉ์ ๋ฌด์์
๋๊น? | Vision loss | {
"A": "ํผ๋ถ ํ์กฐ",
"B": "์๊ณผ ๋ฐ์ ๊ฐ๊ฐ ์ด์",
"C": "์๋ ฅ ์์ค",
"D": "๊ด์ ํต"
} | step1 | C | [
"seeing",
"patient in clinic",
"recently started treatment",
"active",
"patient",
"currently",
"treated with rifampin",
"isoniazid",
"pyrazinamide",
"ethambutol",
"patient",
"not used",
"taking medicines",
"very concerned",
"side effects",
"carbohydrate polymerization inhibiting medication",
"following",
"known side effect"
] | 00000000000000000207 |
32์ธ ๋จ์ฑ์ด ์ ๊ธฐ ๊ฑด๊ฐ ๊ฒ์ง์ ์ํด ์ฃผ์น์๋ฅผ ๋ฐฉ๋ฌธํฉ๋๋ค. ๊ฒ์ฌ ์ค ๊ทธ๋ ์๋ฒ์ง๊ฐ ๋๊ณ ์ถ์ง ์๋ค๋ ์ฐ๋ ค๋ฅผ ํ๋ช
ํฉ๋๋ค. ๊ทธ๋ ์ง๋ 5๋
๋์ ์๋ด์ ์ฑ์ ์ผ๋ก ํ๋ฐํ๊ณ ์ผ๋ถ์ผ์ฒ ๊ด๊ณ๋ฅผ ์ ์งํด ์์ผ๋ฉฐ, ํผ์์ ์ํด ์ฝ๋์ ์ผ๊ด์ฑ ์์ด ์ฌ์ฉํฉ๋๋ค. ๊ทธ๋ ์ฃผ์น์์๊ฒ ์ ๊ด ์์ ์ ๋ฐ๊ณ ์ถ๋ค๊ณ ๋งํฉ๋๋ค. ๊ทธ์ ์๋ด ๋ํ ์ฃผ์น์์ ์ง๋ฃ๋ฅผ ๋ฐ๊ณ ์์ผ๋ฉฐ, ๋ง์ง๋ง ์ง๋ฃ ์ ์์ ์ ์ํ๊ธฐ ๋๋ฌธ์ ์์ ์ ๊ฐ์๋ ฅ์ ์ํฅ์ ๋ฏธ์น ์ ์๋ ์ฝ๋ฌผ์ ์ฒ๋ฐฉ๋ฐ๋ ๊ฒ์ ๋ํด ์ฐ๋ ค๋ฅผ ํ๋ช
ํ์ต๋๋ค. ์ด ํ์์ ์ ๊ด ์์ ์ ๋ํ ์๋ง๊ณผ ๊ด๋ จํ์ฌ ์์ฌ๊ฐ ์ทจํด์ผ ํ ๊ฐ์ฅ ์ ์ ํ ์กฐ์น๋ ๋ฌด์์
๋๊น? | Explain the procedure's benefits, alternatives, and potential complications | {
"A": "ํ์์๊ฒ ์๋ด์ ํจ๊ป ๋์์ ์์ ์ ์ํ๊ณผ ์ด์ ์ ๋ํด ํจ๊ป ๋
ผ์ํ๋๋ก ์ฃผ์ฅํ๋ค",
"B": "์ ์ฐจ์ ์ด์ , ๋์ ๋ฐ ์ ์ฌ์ ํฉ๋ณ์ฆ์ ์ค๋ช
ํ๋ค",
"C": "ํ์์ ์๋ด์๊ฒ ์ ํํ์ฌ ์์ ์ ๋ํ ๋์๋ฅผ ์ป๋๋ค",
"D": "์๋ด๊ฐ ์์ด๋ฅผ ์ํ๊ธฐ ๋๋ฌธ์ ํ์๊ฐ ์์ ์ ๋ฐ์ง ์๋๋ก ๋ง๋ฅํ๋ค"
} | step1 | B | [
"year old man visits",
"primary care physician",
"routine health maintenance examination",
"examination",
"concerns",
"not",
"to",
"father",
"sexually active",
"monogamous",
"wife",
"past",
"years",
"use condoms",
"contraception",
"physician",
"to",
"vasectomy",
"wife",
"patient",
"care",
"physician",
"last appointment",
"concerns over",
"prescribed",
"drugs",
"affect",
"fertility",
"to",
"following",
"most appropriate action",
"physician",
"patient's wish to",
"vasectomy"
] | 00000000000000000208 |
48์ธ ๋จ์ฑ์ด ์๋ด์ ์ํด ์๊ธ์ค๋ก ์ด์ก๋์์ผ๋ฉฐ, ์๋ด๋ ๊ทธ๊ฐ ์ฝ 1๋ถ ๋์ ๊ฒฉ๋ ฌํ๊ฒ ๋ชธ์ ๋ ๋ ๊ฒ์ ๋ชฉ๊ฒฉํ ํ 20๋ถ์ด ์ง๋ ์์ ์ด์์ต๋๋ค. ์ด ์ํผ์๋ ๋์ ๊ทธ๋ ์์ ๋ ๋ชจ๋ฅด๊ฒ ์๋ณ์ ๋ดค์ต๋๋ค. ๊ทธ๋ ์กธ๋ฆฌ๊ณ ๋ฉ์ค๊บผ์์ ๋๋๋๋ค. ๊ทธ๋ ๋ง์ฑ ์์ฝ์ฌ ์ค๋
๋ณ๋ ฅ์ด ์์ผ๋ฉฐ, ์ง๋ 3์ผ ๋์ ๋งค์ผ ๋งฅ์ฃผ 15์บ์ ๋ง์
จ์ต๋๋ค. ์ด์ ์๋ ๋งค์ผ ๋งฅ์ฃผ 8์บ์ ๋ง์
จ์ต๋๋ค. ๋ง์ง๋ง ์์ฃผ๋ 2์๊ฐ ์ ์ด์์ต๋๋ค. ๊ทธ๋ ๋ฌด๊ธฐ๋ ฅํด ๋ณด์
๋๋ค. ํ๋ ฅ ์งํ๋ ์ ์ ๋ฒ์ ๋ด์ ์์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๋ฐ ์ ๊ฒฝํ์ ๊ฒ์ฌ์์๋ ๋ค๋ฅธ ์ด์์ด ๋ฐ๊ฒฌ๋์ง ์์์ต๋๋ค. ์ ์ ์ํ ๊ฒ์ฌ์์ ๊ทธ๋ ํผ๋์ค๋ฌ์ํ๊ณ ์๊ฐ์ ๋ํ ์ง๋จ๋ ฅ์ด ์์ต๋๋ค. ์คํ์ค ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค.
Hematocrit 44.0%
Leukocyte count 12,000/mm3
Platelet count 320,000/mm3
Serum
Na+ 112 mEq/L
Cl- 75 mEq/L
K+ 3.8 mEq/L
HCO3- 13 mEq/L
Urea nitrogen 6 mEq/L
Creatinine 0.6 mg/dL
Albumin 2.1 g/dL
Glucose 80 mg/dL
์ด ํ์์ ํ์ฌ ์ํ์ ๋ํ ๊ธด๊ธ ์น๋ฃ๋ ๋ค์ ์ค ์ด๋ค ๋ถ์์ฉ์ ์ํ์ ์ฆ๊ฐ์ํฌ ์ ์์ต๋๊น?" | Osmotic myelinolysis | {
"A": "Cerebral edema",
"B": "Hyperglycemia",
"C": "Osmotic myelinolysis",
"D": "Wernicke encephalopathy"
} | step2&3 | C | [
"48 year old man",
"brought",
"emergency department",
"wife 20 minutes",
"witnessed",
"vigorously shaking",
"minute",
"episode",
"feels drowsy",
"nausea",
"history of chronic alcoholism",
"drinking",
"beers daily",
"past 3 days",
"time",
"drank",
"beers daily",
"last drink",
"2 hours",
"appears lethargic",
"vital signs",
"normal limits",
"Physical",
"neurologic examinations show",
"abnormalities",
"mental",
"confused",
"not oriented to time",
"Laboratory studies show",
"Leukocyte count",
"Platelet count",
"mEq",
"HCO3",
"mg dL Albumin",
"treatment",
"patient",
"urrent ondition uts ",
"ncreased risk ",
"ollowing dverse events?"
] | 00000000000000000209 |
48์ธ ๋จ์ฑ์ด ์๋ฒฝ ์ผ์ฐ ๊ฐ์ด์ ํ๋ ๋ฏํ ๋๋์ ํธ์ํ๋ฉฐ ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ๊ทธ๋ ํ๊ณจ ์๋์์ ์ง๋๋ฅด๋ ๋ฏํ ๋๋์ด ๋ ๋ค๊ณ ์ค๋ช
ํ๋ฉฐ ์ผ์ชฝ ๋ชฉ์ ํต์ฆ์ด ์๋ค๊ณ ๋ณด๊ณ ํ์ต๋๋ค. ๋ํ, ๊ทธ๋ ํธํก ๊ณค๋์ ํธ์ํฉ๋๋ค. ์ด์ ฏ๋ฐค ๋ฆ๊ฒ ์ง์ ์์ TV๋ฅผ ๋ณด๋ฉด์ ํผ์ ๊ฐ์กฑ์ฉ ๋ผ์๋๋ฅผ ๋จน์์ต๋๋ค. ๊ทธ์ ๊ณผ๊ฑฐ ๋ณ๋ ฅ์ ์ 2ํ ๋น๋จ๋ณ๊ณผ ์ ๋๋ก ์กฐ์ ๋์ง ์๋ ๊ณ ํ์์ผ๋ก ์ค์ํฉ๋๋ค. ํ์๋ ์ข
์ข
์ฝ ๋ณต์ฉ์ ์ํํ ํ๊ณ ๊ถ์ฅ ์๋จ์ ๋ฐ๋ฅด์ง ์๋๋ค๊ณ ์ธ์ ํฉ๋๋ค. ํ์ฌ ๋ณต์ฉ ์ค์ธ ์ฝ๋ฌผ์ aspirin, metformin, ๊ทธ๋ฆฌ๊ณ captopril์
๋๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ ๋์ ๋ง์ด ํ๋ฆฌ๋, ๊ดด๋ก์ํ๋ ๊ณผ์ฒด์ค ๋จ์ฑ์ผ๋ก ๋ํ๋ฌ์ต๋๋ค. ์ฒญ์ง ์ ๋ค์ ์ค ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์๊ฒฌ์ ๋ฌด์์
๋๊น? | Fourth heart sound | {
"A": "Ejection systolic murmur",
"B": "Expiratory wheezes",
"C": "Fixed splitting of the second heart sound",
"D": "Fourth heart sound"
} | step2&3 | D | [
"48 year old man presents early",
"morning",
"emergency department",
"burning sensation",
"chest",
"crushing feeling",
"sternum",
"reports",
"neck pain",
"left side",
"difficulty breathing",
"Late",
"night",
"home",
"eaten",
"family size lasagna",
"watching TV",
"past medical history",
"significant",
"type 2 diabetes",
"poorly controlled hypertension",
"patient admits",
"often neglects to take",
"medications",
"not",
"following",
"diet",
"current medications",
"aspirin",
"metformin",
"captopril",
"Examination reveals",
"distressed",
"overweight male sweating",
"following",
"most likely to",
"found",
"auscultation"
] | 00000000000000000210 |
76์ธ ๋จ์ฑ์ด ๊ฐํ ์ํผ์๋ ํ ๊ฑด์ผ๋ก ์๊ธ์ค๋ก ์ด์ก๋์๋ค. ๋งฅ๋ฐ์ ๋ถ๋น 110ํ์ด๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ์ฐฝ๋ฐฑํจ์ด ๊ด์ฐฐ๋์์ผ๋ฉฐ, ๊ตฌ๊ฐ ๋ด์ ํ์ก์ด ์๋ค. ๋น๊ฒฝ์ ์ด์ฉํ ๋น๊ฐ ๊ฒ์ฌ์์ ํ๋น๊ฐ์์ ํ๋์ฑ ์ถํ์ด ๊ด์ฐฐ๋์๋ค. ํ์ ์นดํ
ํฐ๋ฅผ ์ด์ฉํ ์งํ์ด ์๋๋์์ผ๋ ์ฑ๊ณตํ์ง ๋ชปํ๋ค. ๊ด๋ฆฌ์ ๋ค์ ๋จ๊ณ๋ก์ ๊ฐ์ฅ ์ ์ ํ ์กฐ์น๋ ๋ค์ ๋๋งฅ ์ค ์ด๋ค ๋๋งฅ์ ๊ฐ์ง๋ฅผ ๊ฒฐ์ฐฐํ๋ ๊ฒ์ธ๊ฐ? | Maxillary artery | {
"A": "์ ๋๋ ๋๋งฅ",
"B": "์๋ฉด ๋๋งฅ",
"C": "ํ๋ ๋๋งฅ",
"D": "์์
๋๋งฅ"
} | step1 | D | [
"76 year old man",
"brought",
"emergency room",
"of one episode",
"hemoptysis",
"pulse",
"min",
"Physical examination shows pallor",
"blood in",
"oral cavity",
"Examination",
"nasal",
"nasal speculum shows active bleeding",
"posterior nasal cavity",
"Tamponade",
"balloon catheter",
"attempted",
"success",
"most appropriate next step",
"management",
"ligation",
"branch",
"vessel",
"following arteries"
] | 00000000000000000211 |
์ฐ๊ตฌ์๋ ์๋ผํค๋์ฐ ๋์ฌ ์ฐ๋ฌผ์ด ์ฅ์ ์ผ์ฆ ๋ฐ์์ ์ด๋ป๊ฒ ๋งค๊ฐํ๋์ง ์ฐ๊ตฌํ๊ณ ์์ต๋๋ค. ๊ทธ๋
๋ ์๋ผํค๋์ฐ ๊ฒฝ๋ก์ ๊ฐ๋ณ ๋จ๋ฐฑ์ง์ ๊ตฌ์ฒด์ ์ผ๋ก ํ์ ์ผ๋ก ํ๋ ์ฌ๋ฌ ํจ์ ์ต์ ์ ๋ฅผ ๊ฐ๋ฐํ์ต๋๋ค. ๊ทธ๋
๋ ํํ ์ธ๊ท ๋ณ์์ฒด์ ๋
ธ์ถ๋ ์ฅ์๊ฒ ์ด ์ต์ ์ ๋ฅผ ์ฃผ์ฌํ๊ณ ๊ทธ๋ค์ ํ์ ์ํฅ์ ๋ถ์ํฉ๋๋ค. ๊ทธ๋
์ ํ ์คํ์์, ๊ทธ๋
๋ ๋ฅ์ฝํธ๋ฆฌ์ B4 ์ต์ ์ ๋ฅผ ์ฅ์๊ฒ ์ฃผ์ฌํ๊ณ ๋น์ ์์ ์ธ ์ธํฌ ๋ฐ์์ ๊ด์ฐฐํฉ๋๋ค. ๋ค์ ์ธํฐ๋ฃจํจ ์ค ์ด๋ค ๊ฒ์ด ๋๋ฝ๋ ์์ฑ๋ฌผ ์ค ํ๋์ ๊ธฐ๋ฅ์ ๊ฐ์ฅ ๊ฐ๊น๊ฒ ํ๋ณต์ํฌ ์ ์์ต๋๊น? | Interleukin 8 | {
"A": "์ธํฐ๋ฃจํจ 1",
"B": "์ธํฐ๋ฃจํจ 4",
"C": "์ธํฐ๋ฃจํจ 5",
"D": "์ธํฐ๋ฃจํจ 8"
} | step1 | D | [
"researcher",
"studying",
"arachidonic acid metabolites mediate",
"inflammatory response",
"rats",
"multiple enzyme inhibitors",
"target individual proteins",
"arachidonic acid pathway",
"injects",
"inhibitors",
"rats",
"exposed",
"common bacterial pathogens",
"downstream effects",
"one",
"experiments",
"injects a leukotriene B4 inhibitor",
"rat",
"observes",
"abnormal cell response",
"following interleukins",
"most",
"function",
"one",
"missing products"
] | 00000000000000000212 |
23์ธ ๋จ์ฑ์ด ๋ฐ๋ณต์ ์ธ ํํต, ์จ๊ฐ์จ, ์ฌ๊ณํญ์ง, ๊ทธ๋ฆฌ๊ณ ์ง์๊ฐ ๋๋ฌธ์ ์์ฌ๋ฅผ ์ฐพ์์์ต๋๋ค. ์ฆ์์ ๋๊ฐ ์ฝ 5๋ถ ํ ์ฌํธํก ์ด๋์ผ๋ก ํด์๋ฉ๋๋ค. ๊ทธ๋ ๋ ๋ค๋ฅธ ๋ฐ์์ด ์์๊น ๋ด ๊ฑฑ์ ๋์ด ๋ํ์ ์์
์ ๊ฐ๋ ๊ฒ์ ํผํ๊ณ ์์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ํน์ด์ฌํญ์ด ์์ต๋๋ค. lorazepam ์น๋ฃ๊ฐ ์์๋์์ต๋๋ค. ์ด ํ์์๊ฒ์ ๋ค์ ์ค ์ด๋ค ์ฝ๋ฌผ์ ๋ณ์ฉ ์ญ์ทจ๋ฅผ ํผํด์ผ ํฉ๋๊น? | Diphenhydramine | {
"A": "Diphenhydramine",
"B": "Naloxone",
"C": "Fluoxetine",
"D": "Ondansetron"
} | step1 | A | [
"23 year old man",
"physician",
"recurrent episodes",
"chest pain",
"shortness of breath",
"palpitations",
"sensation",
"choking",
"symptoms usually resolve",
"deep breathing exercises",
"about",
"minutes",
"now",
"graduate school classes",
"worried",
"episode",
"Physical examination",
"unremarkable",
"Treatment",
"lorazepam",
"initiated",
"concurrent intake",
"following drugs",
"patient"
] | 00000000000000000213 |
์ฒด์ง๋์ง์(BMI) 14.5 kg/m2์ 17์ธ ์๋
๊ฐ ์ ๊ฒฝ์ฑ ์์๋ถ์ง ์น๋ฃ๋ฅผ ์ํด ๋ณ์์ ์
์ํ์ต๋๋ค. ํ์์๊ฒ ์ ๋งฅ ์์ก์ ํฌ์ฌํ๊ณ ๋งค์ผ 1,600์นผ๋ก๋ฆฌ๋ฅผ ๊ณต๊ธํ๋ฉฐ ๋งค์ผ 200์นผ๋ก๋ฆฌ์ฉ ๋๋ฆฝ๋๋ค. ์น๋ฃ 5์ผ์งธ์ ํ์๋ ์ ์ฝ๊ณผ ํผ๋ ์ฆ์, ๊ทธ๋ฆฌ๊ณ ์ง์ ๊ฐ์ ์๋ณ์ ๋ณด์
๋๋ค. ๋ค์ ์ค ํ์์ ์ฆ์์ ๊ฐ์ฅ ์ ๋ ฅํ ์์ธ์ด ๋๋ ์์์ ์ํ๋ ๋ฌด์์
๋๊น? | Hypophosphatemia | {
"A": "Hypercalcemia",
"B": "Hypermagnesemia",
"C": "Hypophosphatemia",
"D": "Thiamine deficiency"
} | step2&3 | C | [
"year old girl",
"BMI",
"kg/m2",
"admitted",
"hospital",
"treatment",
"anorexia nervosa",
"patient",
"administered intravenous fluids",
"supplied",
"600 calories daily",
"increase",
"200 calories",
"day",
"day 5",
"treatment",
"patient manifests symptoms",
"weakness",
"confusion",
"dark",
"following clinical conditions",
"most likely cause",
"patient's symptoms"
] | 00000000000000000214 |
25์ธ ์ฌ์ฑ์ด ํ๋ฐฉ ์ถ๋ ์ฌ๊ณ ํ ์๊ธ์ค๋ก ์ด์ก๋์์ผ๋ฉฐ, ๊ทธ๋
๋ ๋ค์ฐจ์ ์์ ๋ฒจํธ๋ฅผ ์ฐฉ์ฉํ ์ด์ ์์์ต๋๋ค. ๋์ฐฉ ์, ๊ทธ๋
๋ ์์์ด ๋ช
๋ฃํ๊ณ ํ๋์ ์
๋๋ค. ๊ทธ๋
๋ ์์ชฝ ๋ฌด๋ฆ์ ํต์ฆ๊ณผ ์ค๋ฅธ์ชฝ ์ฌํ๊ตฌ๋ ๋ถ์์ ์ฌํ ํต์ฆ์ ํธ์ํฉ๋๋ค. ์ฒด์จ์ 37ยฐC (98.6ยฐF), ๋งฅ๋ฐ์ 116ํ/๋ถ, ํธํก์ 19ํ/๋ถ, ํ์์ 132/79 mm Hg์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ์์ชฝ ๋ฌด๋ฆ๋ผ์ ์ํต์ด ์์ต๋๋ค. ์ค๋ฅธ์ชฝ ์ฌํ๊ตฌ๋๋ ์ด์ง ์ ์ํต์ด ์์ต๋๋ค. ์ค๋ฅธ์ชฝ ๋ค๋ฆฌ๋ ์ฝ๊ฐ ์งง์์ง๊ณ , ๊ตด๊ณก๋๊ณ , ๋ด์ ๋๊ณ , ๋ดํ์ ๋์ด ์์ต๋๋ค. ๋๋จธ์ง ๊ฒ์ฌ์์๋ ์ด์ ์๊ฒฌ์ด ์์ต๋๋ค. ๋ค์ ์ค ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ ๋์ ์ง๋จ์ ๋ฌด์์
๋๊น? | Posterior hip dislocation | {
"A": "Femoral neck fracture",
"B": "Anterior hip dislocation",
"C": "Femoral shaft fracture",
"D": "Posterior hip dislocation"
} | step2&3 | D | [
"year old woman",
"brought",
"emergency department",
"involved",
"rear-end collision",
"restrained driver of",
"back car",
"arrival",
"alert",
"active",
"reports pain in both knees",
"severe pain",
"right",
"Temperature",
"98",
"pulse",
"min",
"respirations",
"min",
"blood pressure",
"mm Hg",
"Physical examination shows tenderness",
"knee",
"right groin",
"tender",
"palpation",
"right leg",
"slightly shortened",
"flexed",
"adducted",
"internally rotated",
"examination shows",
"abnormalities",
"following",
"most likely diagnosis"
] | 00000000000000000215 |
ํ ์ฐ๊ตฌ์๊ฐ ์ธ๊ฐ ์ ์ ํ๊ณผ ์ธํฌ ๋ถ์ด์ ์ฐ๊ตฌํ๊ณ ์์ต๋๋ค. ๋ถ์๋ ์๋ ์ผ์์ฒด ๊ฐ์ ์ ์ ๋ฌผ์ง ๊ตํ์ ์ต์ ํ๋ ๋ฐ ์ฌ์ฉ๋ฉ๋๋ค. ์ด ๋ถ์๋ ์ธํฌ ์ฃผ๊ธฐ์ ๋ค์ ์ค ์ด๋ ๋จ๊ณ๋ฅผ ํ์ ์ผ๋ก ํฉ๋๊น? | Prophase I | {
"A": "Telophase I",
"B": "Metaphase II",
"C": "Prophase I",
"D": "Anaphase I"
} | step1 | C | [
"investigator",
"studying human genetics",
"cell division",
"molecule",
"used to inhibit",
"exchange",
"genetic",
"homologous chromosomes",
"following phases",
"cell cycle",
"molecule target"
] | 00000000000000000216 |
์ด๋ค ์ฐ๊ตฌ์๊ฐ ์ ๊ฒฝ ์ธํฌ ์ฌ์์ ์ฐ๊ตฌํ๊ณ ์์ต๋๋ค. ์ ๊ฒฝ ์ธํฌ์ ํ๋ฏธ๊ฒฝ์ ์๊ฐํ๋ฅผ ์ํด, ์๋๋ฆฐ ์ผ๋ฃ๊ฐ ์ฌ์ฉ๋ฉ๋๋ค. ์ผ์ ํ, ์ ๊ฒฝ ์ธํฌ์ ์ธํฌ์ฒด์ ์์๋๊ธฐ๋ง ์๊ฐํ๋๋ฉฐ, ์ถ์ญ์ ์๊ฐํ๋์ง ์์ต๋๋ค. ๋ค์ ์ธํฌ ์์ ์ค ์ด๋ค ์์์ ์กด์ฌ๊ฐ ์ด๋ฌํ ์ผ์ ํจํด์ ๊ฐ์ฅ ์ ์ค๋ช
ํฉ๋๊น? | Rough endoplasmic reticulum | {
"A": "๋ฏธ์ธ ์๊ด",
"B": "ํต",
"C": "๋ฆฌ์์ข",
"D": "์กฐ๋ฉด ์ํฌ์ฒด"
} | step1 | D | [
"investigator",
"studying neuronal regeneration",
"microscopic visualization",
"neuron",
"aniline stain",
"applied",
"staining",
"only",
"soma",
"dendrites",
"neurons",
"visualized",
"not",
"axon",
"Presence of",
"following cellular elements best",
"staining pattern"
] | 00000000000000000217 |
67์ธ ์ฌ์ฑ์ด ์ง๋ 2๊ฐ์ ๋์ ๋ฌดํต์ฑ, ์์ํ ์ปค์ง๋ ์ด๊ฐ ์ฃผ๋ณ์ ๊ถค์์ ์ฃผ์๋ก ์ธ๊ณผ ์์ฌ์๊ฒ ๋ด์ํ๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ๋ถ๊ท์นํ ๋ชจ์์ ๊ถค์์ด ๊ด์ฐฐ๋์์ผ๋ฉฐ, ํฌ๊ธฐ๋ 2cm x 1cm์ด๊ณ , ๊ฐ์ฅ์๋ฆฌ๊ฐ ๋ถ๊ท์นํ๋ฉฐ ํ๋ฉด์ ๊ฐํผ๋ก ๋ฎ์ฌ ์๋ค. ์ด ์ฌ์ฑ์ ํผ๋ถ๊ฐ ํฌ๊ณ ์ผ๊ด์์ ์ฆ๊ธฐ๋ ์ฌ๋์ด๋ค. ์
์ฑ ์ข
์์ ๊ฐ์กฑ๋ ฅ์ ์๋ค. ์ ์ ์ ์ฒด ๊ฒ์ฌ ํ, ์ธ๊ณผ ์์ฌ๋ ๊ตญ์ ๋ง์ทจ ํ์ ๋ณ๋ณ์ ๋ํ ์๊ฒ์ ์ํํ๊ณ ์กฐ์ง์ ์กฐ์ง ๋ณ๋ฆฌํ์ ๊ฒ์ฌ๋ฅผ ์ํด ๋ณด๋ธ๋ค. ๋ณ๋ฆฌ๊ณผ ์์ฌ๋ ํผ๋ถ ํธํ ์ธํฌ ์์ข
์ ์ง๋จ์ ํ์ ํ๋ค. ํ์๊ฐ ์์ธ์ ๋ํด ๋ฌป์, ์ธ๊ณผ ์์ฌ๋ ๋ง์ ๊ฐ๋ฅํ ์์ธ์ด ์์ง๋ง, ํนํ ์์ธ์ B(UVB) ๊ด์ ๊ณผ ๊ฐ์ด ํ๋น์ ๋ฐ๋ณต์ ์ผ๋ก ๋
ธ์ถ๋์ด ์ผ๊ตด์ ํธํ ์ธํฌ ์์ข
์ด ๋ฐ์ํ์ ๊ฐ๋ฅ์ฑ์ด ๋๋ค๊ณ ์ค๋ช
ํ๋ค. ๋ง์ฝ ์ธ๊ณผ ์์ฌ์ ์๊ฒฌ์ด ์ณ๋ค๋ฉด, ๋ค์ ์ค ์ด๋ค ๊ธฐ์ ์ด ์ด ์งํ์ ๋ฐ๋ณ ๊ธฐ์ ์ ๊ฐ์ฅ ๊ด๋ จ์ด ์์ ๊ฐ๋ฅ์ฑ์ด ๋์๊ฐ? | Intrastrand cross-linking of thymidine residues in DNA | {
"A": "DNA ๋ด์ ํฐ๋ฏธ๋ ์๊ธฐ์ ๋ด๋ถ ๊ฐ๊ต ๊ฒฐํฉ",
"B": "์ฌ์ดํด๋ฆฐ D2 ๋ฐํ์ ์ํฅ ์กฐ์ ",
"C": "์ ์ฌ ์ธ์ NF-ฮบB์ ํ์ฑํ",
"D": "๋ฐ์์ฑ ์ฐ์ ์ข
์ ํ์ฑ์ผ๋ก ์ธํ DNA ์์"
} | step1 | A | [
"67 year old woman presents",
"surgeon",
"painless",
"slowly",
"ulcer",
"region",
"last",
"months",
"physical examination",
"irregular shaped ulcer",
"2",
"dimensions",
"irregular margins",
"crusting",
"surface",
"woman",
"fair-skinned individual",
"loves to go sunbathing",
"family history",
"malignancy",
"complete physical examination",
"surgeon performs",
"biopsy",
"lesion",
"local anesthesia",
"sends",
"tissue",
"histopathological examination",
"pathologist confirms the diagnosis of squamous cell carcinoma",
"skin",
"cause",
"surgeon",
"possible causes",
"likely",
"squamous cell carcinoma",
"face due to repeated exposure",
"ultraviolet rays",
"sun",
"ultraviolet",
"rays",
"surgeons opinion",
"correct",
"following mechanisms",
"most likely involved",
"pathogenesis",
"condition"
] | 00000000000000000218 |
67์ธ ๋จ์ฑ์ด ๋ฐ์ด ๋ฐ ๊ฒฝ๋ จ์ฑ ๋ณตํต๊ณผ ํจ๊ป ๋ค๋์ ์์ฑ ์ค์ฌ ์ฆ์์ผ๋ก ์์ฌ์๊ฒ ๋ด์ํ์ต๋๋ค. ๊ทธ๋ ํธํก๊ธฐ ๊ฐ์ผ ์น๋ฃ๋ฅผ ์ํด ์ฝ 1์ฃผ์ผ ๋์ ์ธํฝ์ฌ(cefixime) ํญ์์ ์น๋ฃ๋ฅผ ๋ฐ๊ณ ์์์ต๋๋ค. ๋ณ์ ์ง์ฐฐ ์ ๋งฅ๋ฐ์ 112ํ/๋ถ, ํ์์ 100/66 mm Hg, ํธํก์๋ 22ํ/๋ถ, ์ฒด์จ์ 38.9ยฐC (102.0ยฐF)์
๋๋ค. ๊ตฌ๊ฐ ์ ๋ง์ ๊ฑด์กฐํด ๋ณด์ด๋ฉฐ ๋ณต๋ถ๋ ์ ๋ฐ์ ์ผ๋ก ๋ชจํธํ ์ํต๊ณผ ํจ๊ป ๋ถ๋๋ฝ์ต๋๋ค. ์ง์ฅ ์์ง ๊ฒ์ฌ๋ ์ ์์
๋๋ค. ์คํ์ค ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค.
Hemoglobin 11.1 g/dL
Hematocrit 33%
Total leucocyte count 16,000/mm3
Serum lactate 0.9 mmol/L
Serum creatinine 1.1 mg/dL
์ง๋จ์ ํ์ ํ๋ ๋ฐ ๊ฐ์ฅ ์ ํฉํ ๊ฒ์ ๋ฌด์์
๋๊น? | Identification of C. difficile toxin in stool | {
"A": "Identification of C. difficile toxin in stool",
"B": "Colonoscopy",
"C": "Abdominal X-ray",
"D": "CT scan of the abdomen"
} | step2&3 | A | [
"67 year old man presents",
"physician",
"watery diarrhea",
"fever",
"crampy abdominal pain",
"taking",
"antibiotic course",
"cefixime",
"about",
"week to treat",
"respiratory tract infection",
"doctors office",
"pulse",
"min",
"blood pressure",
"100 66 mm Hg",
"respirations",
"min",
"temperature",
"oral mucosa appears dry",
"abdomen",
"soft",
"vague diffuse tenderness",
"digital rectal examination",
"normal",
"Laboratory studies show",
"Hemoglobin",
"g dL Hematocrit 33",
"Total leucocyte count",
"Serum lactate",
"9 mmol/L",
"creatinine",
"mg dL",
"most likely to confirm",
"diagnosis"
] | 00000000000000000219 |
45์ธ ๋จ์๊ฐ 3์ผ ๋์ ๋ฐ์ด๊ณผ ๋ฉ๋ฆ์ ์ฝ๊ฒ ๊ฒฝํํ์ฌ ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ๊ทธ๋ 2์ฃผ ๋์ ํผ๋ก๊ฐ์ ๋๊ปด์์ต๋๋ค. ๊ทธ๋ ๊ณผ๊ฑฐ ๋ณ๋ ฅ์ด ์์ผ๋ฉฐ, ๋ณต์ฉํ๋ ์ฝ๋ฌผ๋ ์์ต๋๋ค. ๊ฐํธ์ฌ๋ ์ ๋งฅ ์ฃผ์ฌ ๋ผ์ธ์์ ๊ณผ๋ํ ์ถํ์ ๋ณด๊ณ ํ์ต๋๋ค. ๊ทธ๋ ํก์ฐ์ด๋ ์์ฃผ๋ฅผ ํ์ง ์์ต๋๋ค. ์ฒด์จ์ 38.2ยฐC (102.6ยฐF), ๋งฅ๋ฐ์ 105/๋ถ, ํธํก์๋ 18/๋ถ, ํ์์ 110/70 mm Hg์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ๊ทธ๋ ํ์ฒด์ ๋ค๋ฐ์ฑ ์๋ฐ์ฆ์ด ์๊ณ , ํ๋ฆฌ์ ๋๋ถ์ ์ฌ๋ฌ ๋ฉ์ด ์์ต๋๋ค. ๊ตฌ๊ฐ์ ์ ์ ์ถํ์ด ๊ด์ฐฐ๋ฉ๋๋ค. ์์ชฝ ๊ฒฝ๋ถ์ ๋ฌดํต์ฑ ๋ฆผํ์ ๋ณ์ฆ์ด ๊ฐ์ง๋ฉ๋๋ค. ํ, ์ฌ์ฅ ๋ฐ ๋ณต๋ถ ๊ฒ์ฌ์์๋ ๋ค๋ฅธ ์ด์ ์๊ฒฌ์ด ๋ํ๋์ง ์์ต๋๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค.
ํ์์ 8 g/dL
ํ๊ท ์ ํ๊ตฌ ์ฉ์ 90 ฮผm3
๋ฐฑํ๊ตฌ ์ 18,000/mm3
ํ์ํ ์ 10,000/mm3
๋ถ๋ถ ํธ๋กฌ๋ณดํ๋ผ์คํด ์๊ฐ(ํ์ฑํ) 60์ด
ํ๋กํธ๋กฌ๋น ์๊ฐ 25์ด (INR: 2.2)
ํผ๋ธ๋ฆฐ ๋ถํด ์์ฑ๋ฌผ ์์ฑ
ํ์ฒญ ์ ์ฐ ํ์์ ํจ์ 1,000 U/L
๊ธฐ์์ ์ผ์ ๋ง์ด ํ์ก ๋๋ง ๊ฒ์ฌ๊ฐ ์ด๋ฏธ์ง๋ก ์ ์๋ฉ๋๋ค. ํ์์๊ฒ ์ ๋งฅ ์์ก, ํ์ก ์ ์ ๋ฐ ํญ์์ ๊ฐ ํฌ์ฌ๋ฉ๋๋ค. ๊ฐ์ฅ ์ ๋ ฅํ ์ง๋จ์ ๋ฐํ์ผ๋ก, ์ด ํ์์๊ฒ ํ์ฌ ๊ฐ์ฅ ์ ํฉํ ์น๋ฃ๋ฒ์ ๋ฌด์์
๋๊น? | All-trans retinoic acid (ATRA) | {
"A": "์ -ํธ๋์ค ๋ ํฐ๋
ธ์ฐ (ATRA)",
"B": "์กฐํ๋ชจ์ธํฌ ์ด์",
"C": "๋ฆฌํญ์๋ง, ์ฌ์ดํด๋กํฌ์คํ๋ฏธ๋, ๋
์๋ฃจ๋น์ , ๋นํฌ๋ฆฌ์คํด ๋ฐ ํ๋ ๋๋์ (R-CHOP)",
"D": "์๋๋ฆฌ์๋ง์ด์ , ๋ธ๋ ์ค๋ง์ด์ , ๋น๋ธ๋ผ์คํด ๋ฐ ๋ค์นด๋ฐ์ง (ABVD)"
} | step2&3 | A | [
"year old man presents",
"emergency department",
"fever",
"easy bruising",
"3 days",
"fatigue",
"2 weeks",
"past medical history",
"takes",
"medications",
"Excessive bleeding",
"intravenous lines",
"reported",
"nurse",
"not smoke",
"drink alcohol",
"temperature",
"pulse",
"min",
"respiration rate",
"min",
"blood pressure",
"70 mm Hg",
"physical examination",
"multiple purpura",
"lower extremities",
"several ecchymoses",
"lower back",
"buttocks",
"Petechiae",
"soft palate",
"Cervical painless lymphadenopathy",
"detected",
"sides",
"examination",
"lungs",
"heart",
"abdomen shows",
"abnormalities",
"laboratory test results",
"follows",
"Hemoglobin",
"g",
"Mean corpuscular volume 90 m3 Leukocyte count",
"mm3 Platelet",
"Partial thromboplastin time",
"activated",
"60 seconds Prothrombin time",
"INR",
"2.2",
"Fibrin split products Positive Lactate dehydrogenase",
"serum",
"U/L",
"Giemsa-stained peripheral blood smear",
"shown",
"image",
"Intravenous fluids",
"blood products",
"antibiotics",
"given",
"patient",
"Based",
"likely diagnosis",
"following",
"best therapy",
"patient",
"time"
] | 00000000000000000220 |
์ํ 2๊ฐ์ ๋ ์์๊ฐ ๊ฑด๊ฐ ๊ฒ์ง์ ์ํด ์์ฌ์๊ฒ ๋ฐ๋ ค์์ก๋ค. ์์๋ 39์ฃผ ์์ ๊ธฐ๊ฐ์ ์์ฐ ์ง์ ๋ถ๋ง์ ํตํด ํ์ด๋ฌ์ผ๋ฉฐ, ๋ชจ์ ์์ ๋ง ํ๊ณ ์๋ค. ์ถ์ ์ ๋ชธ๋ฌด๊ฒ๋ 3,400 g (7 lb 8 oz)์ด์๋ค. ์์ฌ ์ง์ฐฐ์ค์์ ์์๋ ๊ฑด๊ฐํด ๋ณด์ธ๋ค. ๋งฅ๋ฐ์ 136/min์ด๊ณ , ํธํก์ 41/min์ด๋ฉฐ, ํ์์ 82/45 mm Hg์ด๋ค. ๋ชธ๋ฌด๊ฒ๋ 5,200 g (11 lb 8 oz)์ด๊ณ , ํค๋ 57.5 cm (22.6 in)์ด๋ค. ์ ์ฒด ๊ฒ์ฌ์ ๋๋จธ์ง ๋ถ๋ถ์ ์ ์์ด๋ค. ๋ค์ ๋ฐ๋ฌ ์ด์ ํ ์ค ์ด ํ์๊ฐ ๊ฐ์ฅ ์ ๋ฌ์ฑํ์ ๊ฐ๋ฅ์ฑ์ด ๋์ ๊ฒ์ ๋ฌด์์ธ๊ฐ? | Smiles in response to face | {
"A": "๋น๋์นญ ๊ฐ์ง ๋ชฉ ๋ฐ์ฌ ๋ถ์ฌ",
"B": "๋จ์์ ์น์์ด",
"C": "์ผ๊ตด์ ๋ฐ์ํ์ฌ ๋ฏธ์",
"D": "์์ ์ ์์ ์ณ๋ค๋ด"
} | step2&3 | C | [
"2 month old",
"brought",
"physician",
"well",
"born",
"weeks gestation",
"spontaneous vaginal delivery",
"breastfed",
"3 400 g",
"8 oz",
"birth",
"physician's office",
"appears well",
"pulse",
"min",
"respirations",
"min",
"blood pressure",
"mm Hg",
"5 200 g",
"8 oz",
"measures 57",
"length",
"physical examination",
"normal",
"following developmental milestones",
"patient",
"likely met"
] | 00000000000000000221 |
40์ธ ์ฌ์ฑ์ด ์๊ฐ์๊ฐ์ ์๋์น ์์ ์ฒด์ค ๊ฐ์, ๋ช
์น ํต์ฆ ๋ฐ ๋ณต๋ถ ์๋ฐ๊ฐ์ ํธ์ํ๋ฉฐ ๋ด์ํ์ต๋๋ค. ๊ทธ๋
๋ metformin์ผ๋ก ์ ์กฐ์ ๋๋ ๋น๋จ๋ณ์ ์๊ณ ์์ง๋ง ๋ค๋ฅธ ๋ณ๋ ฅ์ ์์ต๋๋ค. ์ด์ ์์ ๊ฒฝํ์ ์์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ์์ฌ๋ ๊ทธ๋
์ ๋ชฉ์ ๊ฐ์์ ๋ฒจ๋ฒณ ๊ฐ์ ์์ ์นจ์ฐฉ ๋ถ์๋ฅผ ๋ฐ๊ฒฌํฉ๋๋ค. ๋ํ ์์ฌ๋ ๋น๋ํด์ง ์ผ์ชฝ ์๊ณจ ์ ๋ฆผํ์ ์ ๋ฐ๊ฒฌํฉ๋๋ค. ๋ด์๊ฒฝ ๊ฒ์ฌ ๊ฒฐ๊ณผ ์๋ฒฝ์ด ์ก์์ผ๋ก ๋๊บผ์์ง ๊ฒ์ผ๋ก ๋ณด์
๋๋ค. ๋ค์ ์ค ์๊ฒ์์ ๊ฐ์ฅ ํํ๊ฒ ๊ด์ฐฐ๋ ์ ์๋ ์๊ฒฌ์ ๋ฌด์์
๋๊น? | Cells with central mucin pool | {
"A": "Cells with central mucin pool",
"B": "Keratin pearls",
"C": "Psammoma bodies",
"D": "Peyer's patches"
} | step1 | A | [
"40 year old female",
"several months of unintentional weight loss",
"epigastric pain",
"sensation of abdominal pressure",
"diabetes well-controlled",
"metformin",
"prior medical history",
"not",
"surgeries",
"physical exam",
"doctor",
"brown",
"areas",
"pigmentation",
"neck",
"doctor",
"enlarged",
"left supraclavicular node",
"Endoscopic findings show",
"stomach wall",
"appears to",
"thickened",
"following findings",
"most likely",
"seen",
"biopsy"
] | 00000000000000000222 |
6์ธ ๋จ์์์ด๊ฐ ์ ์น์ ์ ์๋๊ณผ ํจ๊ป ๊ตฌ๊ธ์ฐจ๋ก ์๊ธ์ค์ ์ค๋ ค ์์ต๋๋ค. ์๊ธ์ค ์ง์๋ค์ ๊ทธ์ ๋ถ๋ชจ์๊ฒ ์ฐ๋ฝ์ ์๋ํ์ง๋ง ์ฐ๋ฝ์ด ๋ฟ์ง ์์์ต๋๋ค. ์์ด์ ๋ณ๋ ฅ์ ์๋ ค์ง์ง ์์์ต๋๋ค. ์ ์๋์ ๋ฐ๋ฅด๋ฉด, ์์ด๋ ์น๊ตฌ๋ค๊ณผ ํจ๊ป ๊ตฌ๋ด์๋น์์ ์์ฌํ๋ ์ค ๊ฐ์๊ธฐ ๊ฐ๋ ค์์ ํธ์ํ๋ฉฐ ์ ์ ์ ๋ฐ์ง์ด ์๊ฒผ์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ๋ฏธ๋ง์ฑ ๋๋๋ฌ๊ธฐ์ ํ ๋ถ์ข
์ด ๋๋๋ฌ์ง๊ฒ ๋ํ๋ฌ์ต๋๋ค. ๊ทธ์ ๋งฅ๋ฐ์ 100ํ/๋ถ์ด๊ณ ํ์์ 90/60 mmHg์
๋๋ค. ์์ด๋ ๊ฒ์ ์ง๋ฆฐ ๋ฏ ๋ณด์ด๋ฉฐ ๋ถ๋ชจ๋์ด ๋์ฐฉํ ๋๊น์ง ์ด๋ค ์น๋ฃ๋ ๋ฐ๊ณ ์ถ์ง ์๋ค๊ณ ๋งํฉ๋๋ค. ์ด ํ์์ ๊ด๋ฆฌ์ ์์ด ๋ค์์ผ๋ก ๊ฐ์ฅ ์ ์ ํ ๋จ๊ณ๋ ๋ฌด์์
๋๊น? | Immediately administer epinephrine and sedate and intubate the patient | {
"A": "ํ์์ ๋ถ๋ชจ์๊ฒ ๊ณ์ ์ ํํ๊ณ ์ ํ๋ก ๊ตฌ๋ ๋์๋ฅผ ๋ฐ์ ๋๊น์ง ์ฝ๊ดํ์ง ๋ง์ญ์์ค.",
"B": "์ฆ์ epinephrine์ ํฌ์ฌํ๊ณ ํ์๋ฅผ ์ง์ ์ํจ ํ ์ฝ๊ดํ์ญ์์ค.",
"C": "ํ์์ ์ ์๋์ผ๋ก๋ถํฐ ์ฝ๊ด์ ๋ํ ์๋ฉด ๋์๋ฅผ ๋ฐ์ผ์ญ์์ค.",
"D": "ํ์์ ๋ถ๋ชจ๊ฐ ๋์ฐฉํ ๋๊น์ง ๊ธฐ๋ค๋ฆฌ๊ณ , ํ์๋ฅผ ์ง์ ์ํค๊ณ , ์ฝ๊ดํ๊ธฐ ์ ์ ์๋ฉด ๋์๋ฅผ ๋ฐ์ผ์ญ์์ค."
} | step1 | B | [
"year old boy",
"brought",
"emergency room",
"ambulance",
"kindergarten teacher",
"Emergency department staff attempt to call",
"parents",
"reached",
"boys medical history",
"unknown",
"teacher",
"boy",
"eating",
"cafeteria",
"friends",
"itching",
"widespread rash",
"Physical exam",
"notable",
"diffuse hives",
"tongue edema",
"pulse",
"100 min",
"blood pressure",
"90 60 mmHg",
"boy appears frightened",
"not",
"treatment",
"parents",
"following",
"next best step",
"management",
"patient"
] | 00000000000000000223 |
12๊ฐ์ ๋ ๋จ์์์ด๊ฐ ๊ฑด๊ฐ ๊ฒ์ง์ ์ํด ์์ฌ์๊ฒ ์๋ค. ๊ทธ๋ ์์ 38์ฃผ์ ํ์ด๋ฌ์ผ๋ฉฐ ํค๋ 48 cm (19 in), ๋ชธ๋ฌด๊ฒ๋ 3061 g (6 lb 12 oz)์ด์๋ค. ํ์ฌ ํค๋ 60 cm (24 in), ๋ชธ๋ฌด๊ฒ๋ 7,910 g (17 lb 7 oz)์ด๋ค. ๊ทธ๋ ํ ์์ ์ก๊ณ ๊ฑธ์ ์ ์์ผ๋ฉฐ ์์ ๊ณต์ ๋์ง ์ ์๋ค. ๊ทธ๋ ์์ง์๊ฐ๋ฝ๊ณผ ๊ฒ์ง์๊ฐ๋ฝ ์ฌ์ด์ ๋ฌผ๊ฑด์ ์ง์ ์ ์๋ค. ๊ทธ๋ 'bye-bye'๋ผ๊ณ ์์ ํ๋ค ์ ์๋ค. ๊ทธ๋ 'mama', 'dada', 'uh-oh'๋ผ๊ณ ๋งํ ์ ์๋ค. ๊ทธ๋ ํผ์ ๋ฏ์ ์ฌ๋๊ณผ ๋๋๋ก ๋ด๋ฒ๋ ค๋๋ฉด ์ด๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ์ด์ ์๊ฒฌ์ ๋ณด์ด์ง ์๋๋ค. ๋ค์ ์ค ์ด ์์ด์๊ฒ์ ๊ฐ์ฅ ์ง์ฐ๋์์ ๊ฐ๋ฅ์ฑ์ด ๋์ ๊ฒ์ ๋ฌด์์ธ๊ฐ? | Growth | {
"A": "Gross motor skills",
"B": "Growth",
"C": "Fine motor skills",
"D": "Social skills"
} | step2&3 | B | [
"month old boy",
"brought",
"physician",
"well",
"born",
"weeks",
"gestation",
"48",
"length",
"g",
"oz",
"currently 60",
"length",
"7",
"g",
"17",
"7 oz",
"walk",
"one hand held",
"throw",
"small ball",
"pick",
"object",
"thumb",
"index finger",
"wave",
"mama",
"oh",
"cries",
"left to play",
"alone",
"Physical examination shows",
"abnormalities",
"following",
"most likely delayed",
"child"
] | 00000000000000000224 |
27์ธ ์ฌ์ฑ์ด ์ฐ์ธก ํ๋ณต๋ถ ํต์ฆ ๋ฐ ์ง ์ถํ์ ์ฃผ์๋ก ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ์ค์ฌ, ๋ณ๋น ๋๋ ํ๋ณ์ ๋ถ์ธํฉ๋๋ค. ๋ณ๋ ฅ์ ํน์ด์ฌํญ์ด ์์ต๋๋ค. ๋ด๋ฐฐ๋ฅผ ํผ์ฐ๊ฑฐ๋ ์ ์ ๋ง์์ง ์์ต๋๋ค. ๋จํธ๊ณผ ์ฑ์ํ์ ํ๊ณ ์์ผ๋ฉฐ ํผ์ ๋ฐฉ๋ฒ์ผ๋ก IUD๋ฅผ ์ฌ์ฉํ๊ณ ์์ต๋๋ค. ์ฒด์จ์ 37.2 ยฐC (99.0ยฐF), ํ์์ 110/70 mm Hg, ๋งฅ๋ฐ์ 80/min, ํธํก์๋ 12/min์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ์ฐ์ธก ์๊ถ ๋ถ์๊ธฐ ๋ถ์์์ ๊ตญ์์ ์ธ ์ํต์ด ์์ง๋ง ์ข
๊ดด๋ ์ด์ง๋์ง ์์ต๋๋ค. ๋ง์ง๋ง ์๊ฒฝ์ผ์ 8์ฃผ ์ ์ด์์ต๋๋ค. ๋ค์ ์ค ์ด ํ์์ ์ง๋จ๊ณผ ๊ฐ์ฅ ๊ด๋ จ์ด ์๋ ๊ฒ์ ๋ฌด์์
๋๊น? | Positive urinary beta-HCG and no intrauterine mass | {
"A": "Physical examination ๊ฒฐ๊ณผ ๋ฐ๋ ์ํต ๋ฐ McBurney's point ์ํต์ด ๋ํ๋จ",
"B": "์๋ณ beta-HCG ์์ฑ ๋ฐ ์๊ถ ๋ด ์ข
๊ดด ์์",
"C": "Barium enema ๊ฒ์ฌ์์ ๊ฒฐ์ฅ์ ์ง์ฑ ๊ฒ์ค์ด ๋ณด์",
"D": "์๋ณ beta-HCG ์์ฑ ๋ฐ ์๊ถ ๋ด ์ผ๋ถ ์์ ์ฐ๋ฌผ ์กด์ฌ"
} | step2&3 | B | [
"27 year old woman presents",
"emergency department",
"right lower quadrant abdominal pain",
"vaginal spotting",
"denies diarrhea",
"constipation",
"blood in",
"stool",
"medical history",
"unremarkable",
"not use tobacco",
"drink alcohol",
"sexually active",
"husband",
"uses",
"IUD",
"contraception",
"temperature",
"99",
"blood pressure",
"70 mm Hg",
"pulse",
"80 min",
"respiratory rate",
"min",
"physical examination reveals localized tenderness",
"right",
"masses",
"palpated",
"LMP",
"weeks",
"following",
"most likely associated with",
"patients diagnosis"
] | 00000000000000000225 |
๋น๋จ๋ณ, ๊ณ ํ์, ๊ทธ๋ฆฌ๊ณ ๊ณ ์งํ์ฆ์ ๊ณผ๊ฑฐ ๋ณ๋ ฅ์ ๊ฐ์ง 58์ธ ๋จ์ฑ์ด ๋ฉฐ์น ๋์ ์ ์ ์์ง ์๊ณ ์ต๊ทผ์ ์ฌ๋ฌ ์ ์ฉ์นด๋๋ฅผ ๊ฐ์คํ์ฌ ํ๋๊น์ง ์ฌ์ฉํ ๊ฒ์ ์๋ด๊ฐ ๋ฐ๊ฒฌํ ํ ์๊ธ์ค๋ก ์ด์ก๋์์ต๋๋ค. ์๋ด๋ ๋ํ ๊ทธ๊ฐ ๋ฐํ
๋ ์ง์
์ ๊ทธ๋ง๋์๊ณ ์ง๋ ๋ช ์ฃผ ๋์ ์ง๋์น๊ฒ ๋ง์ด ๋ง๊ณ ์ฝ๊ฒ ์ง์ฆ์ ๋๋ค๊ณ ๋ณด๊ณ ํฉ๋๋ค. ํ์๋ ์ด์ ์ ์ ์ ๊ณผ์ ๋ณ๋ ฅ์ด ์์ต๋๋ค. ์ผ์์ ์ธ ์ํ์ ๊ฒ์ฌ, ์กฐ์ฌ ๋ฐ ๋
์ฑ ๊ฒ์ฌ๋ ์ํ์ ์์ธ์ด๋ ์ฝ๋ฌผ ๋จ์ฉ์ ๋ฐฐ์ ํฉ๋๋ค. ์คํ์ค ๊ฒฐ๊ณผ๋ ๋ง์ฑ์ ์ผ๋ก ์์๋ ์ ์ฅ ๊ธฐ๋ฅ๊ณผ ์ผ์นํฉ๋๋ค. ์ด ํ์๋ฅผ ์ํ ๊ฐ์ฅ ์ ์ ํ ๋จ์ผ ์น๋ฃ๋ฒ์ ๋ฌด์์
๋๊น? | Valproic acid | {
"A": "Valproic acid",
"B": "Lithium",
"C": "Pregabalin",
"D": "Lamotrigine"
} | step1 | A | [
"58 year old man",
"past medical history of diabetes",
"hypertension",
"hyperlipidemia",
"brought",
"emergency department",
"wife",
"observed",
"go",
"sleep",
"several days",
"recently open",
"out",
"credit cards",
"reports",
"quit",
"job",
"excessively talkative",
"easily",
"weeks",
"patient",
"previous psychiatric history",
"Routine medical examination",
"investigations",
"toxicology rule out",
"medical cause",
"substance abuse",
"Lab results",
"consistent with",
"impaired renal function",
"single best treatment",
"patient"
] | 00000000000000000226 |
42์ธ ์ฌ์ฑ ํ์๊ฐ ํ ๋ฌ ์ ๋ถํฐ ์์๋ ๋ํ ํ๋ณต๋ถ ํต์ฆ, ์์ ๋ถ์ง, 5kg (11-lb) ์ฒด์ค ๊ฐ์์ ๋ํ ํ๊ฐ๋ฅผ ๋ฐ๊ธฐ ์ํด ์์ฌ๋ฅผ ์ฐพ์์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์๋ ์ด์ ์๊ฒฌ์ด ๊ด์ฐฐ๋์ง ์์์ต๋๋ค. ๊ณจ๋ฐ ์ด์ํ ๊ฒ์ฌ ๊ฒฐ๊ณผ ์์ธก ๋์ ๋น๋์ ์ง์ฅ ์๊ถ์ ๋ด ์ก์ฒด๊ฐ ๊ด์ฐฐ๋์์ต๋๋ค. ๋์ ์๊ฒ ํ๋ณธ์์๋ ํธํํ๊ณ ์ฃผ๋ณ๋ถ์ ์์นํ ํต์ ๊ฐ์ง ๋ค์์ ๋ฅ๊ธ๊ณ ์ ์ก์ผ๋ก ์ฑ์์ง ์ธํฌ๊ฐ ๊ด์ฐฐ๋์์ต๋๋ค. ์ด ํ์์ ์ถ๊ฐ ํ๊ฐ์์ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์๊ฒฌ์ ๋ค์ ์ค ๋ฌด์์
๋๊น? | Gastric wall thickening | {
"A": "TSH ์์น ๊ฐ์",
"B": "ํ
์คํ ์คํ
๋ก ์์น ์ฆ๊ฐ",
"C": "์ง์ ํธ๋ฅธ์ ๋ณต๋ง ๋ฐ์ ",
"D": "์๋ฒฝ ๋นํ"
} | step1 | D | [
"year old woman",
"physician",
"evaluation",
"month history",
"dull lower abdominal pain",
"decreased appetite",
"5 kg",
"weight loss",
"Physical examination shows",
"abnormalities",
"Pelvic ultrasonography shows bilateral ovarian enlargement",
"free fluid",
"rectouterine pouch",
"Biopsy specimens",
"ovaries show multiple",
"round",
"mucin filled cells",
"flat",
"peripheral nuclei",
"Further evaluation of",
"patient",
"most likely to show",
"following findings"
] | 00000000000000000227 |
71์ธ ๋จ์ฑ์ด 2์ผ ๋์ ์ค๋ฅธ์ชฝ ์๋ชฉ ํต์ฆ์ ํธ์ํ๋ฉฐ ์ง๋ฃ์ค์ ๋ด์ํ์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ์ค๋ฅธ์ชฝ ์๋ชฉ์ ๋ฑ์ชฝ์ ๋ฐ์ ๊ณผ ๋ถ์ข
์ด ๊ด์ฐฐ๋์์ต๋๋ค. ๊ทธ๋ ์๋ชฉ์ ๊ทน์ฌํ ๊ฐ๋ ๋ฒ์์์ ํต์ฆ์ ๋๊ผ์ต๋๋ค. ๊ทธ์ ๋ณ๋ ฅ์๋ 2๋ฒ์ ๊ณ ๊ด์ ์นํ์ , ์์ชฝ ์ฒซ ๋ฒ์งธ ์ค์กฑ์ง๊ด์ ์์ 2๋ฒ์ ํตํ ์ํผ์๋, ๊ณ ํ์์ด ํฌํจ๋ฉ๋๋ค. ์ดํ ํ, ์ค๋ฅธ์ชฝ ์๋ชฉ๊ณผ ์์ ๋ฑ์ชฝ ๋ถ์ข
์ด ์ฆ๊ฐํ์ต๋๋ค. ์๋ชฉ ๊ตด๊ณก์ ์ฌํ ํต์ฆ๊ณผ ํจ๊ป 80%๋ก ์ ํ๋์์ต๋๋ค. ํต์ฆ์ ์๋ฐฐ๋ผ ์ด์ง ์ ๋ํ๋ฌ์ต๋๋ค. ๊ณจ์ ์ด ์์ฌ๋์ด ํ์๋ ๋ฐฉ์ฌ์ ์ดฌ์์ ์ํด ์ฃผ์น์์๊ฒ ์๋ขฐ๋์์ต๋๋ค. ์ด๋ฌํ ์๊ฒฌ์ ํตํ์ฑ ๊ด์ ์ผ๊ณผ ์ผ์นํ์ต๋๋ค. ์ด ๊ณผ์ ์ ๊ด๋ จ๋ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ฌ์ดํ ์นด์ธ์ ๋ฌด์์
๋๊น? | IL-1 | {
"A": "IL-1",
"B": "IL-10",
"C": "INFฮณ",
"D": "IL-5"
} | step1 | A | [
"71 year old man presents",
"clinic",
"complaints of right wrist pain",
"2 days",
"examination",
"redness",
"swelling",
"noted",
"dorsal aspect of",
"right wrist",
"pain with extreme range of motion",
"wrist",
"history includes 2 hip replacements",
"2 previous episodes of gout",
"first metatarsophalangeal joints",
"hypertension",
"Two days later",
"swelling",
"increased",
"dorsal aspect of",
"right wrist",
"hand",
"Wrist flexion",
"limited",
"80",
"severe pain",
"pain",
"present",
"palpation of",
"scaphoid bone",
"Due to",
"suspicion",
"fracture",
"patient",
"referred",
"general practitioner",
"radiographs",
"findings",
"consistent with gouty arthritis",
"most likely cytokine involved",
"process"
] | 00000000000000000228 |
์ฐ๊ตฌ์ ์ง๋จ์ ๊ตญ์ ๋ฐ์ ๋น๋ ๊ฐ์์ ์์ด ์๋ก์ด ์๋ฐ๋
ธ์ A1 ์์ฉ์ฒด ํจ๋ฅ์ ๋ฅผ ํ์ค ํญ๊ฐ์ง ์น๋ฃ์ ์ถ๊ฐํ๋ ๊ฒ์ ํจ๋ฅ์ ํ๊ฐํ๊ธฐ ์ํด ๋ฌด์์ ์์ ์ํ์ ์ค์ํ๋ค. ์กฐํฉ ์๋ฒ์ ๋ฐ๋ ํ์(n = 200)๊ฐ ํ์ค ์น๋ฃ๋ง ๋ฐ๋ ํ์(n = 200; p < 0.01)์ ๋นํด ๋ฐ์ ๋น๋๊ฐ ๋ ๋ฎ์ ๊ฒ์ผ๋ก ๋ํ๋ฌ๋ค. ๊ทธ๋ฌ๋ ์๋ก์ด ์ฝ๋ฌผ์ ๋ณต์ฉํ ์ฐธ๊ฐ์ ์ค ์ผ๋ถ๋ ์ฌํ ์กธ์์ ํธ์ํ๋ค. ์ฐ๊ตฌ์๋ค์ ์กธ์์ด ์ผ์ ๊ธฐ๋ฅ์ ์ง์ฅ์ ์ฃผ๋์ง ํ๊ฐํ๊ธฐ ์ํด ์ ๋๋ ์๋์ค ์ค๋ฌธ์ง๋ฅผ ์ฌ์ฉํ์ฌ ์กฐํฉ ์น๋ฃ ๊ทธ๋ฃน๊ณผ ํ์ค ์น๋ฃ ๊ทธ๋ฃน ๋ชจ๋์๊ฒ ์ค๋ฌธ ์กฐ์ฌ๋ฅผ ์ค์ํ๋ค. ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ๋ค.
์ผ์ ๊ธฐ๋ฅ ๋ฐฉํด ์ (ํ์ ์) ์๋์ค (ํ์ ์)
์กฐํฉ ์น๋ฃ ๊ทธ๋ฃน 115 85
ํ์ค ์น๋ฃ ๊ทธ๋ฃน 78 122
๋ค์ ์ค ์ด๋ฌํ ๊ฒฐ๊ณผ์ ํต๊ณ์ ์ ์์ฑ์ ํ๊ฐํ๋ ๋ฐ ๊ฐ์ฅ ์ ํฉํ ํต๊ณ์ ๋ฐฉ๋ฒ์ ๋ฌด์์ธ๊ฐ?" | Chi-square test | {
"A": "Multiple linear regression",
"B": "Chi-square test",
"C": "Unpaired t-test",
"D": "Analysis of variance"
} | step1 | B | [
"A group",
"investigators",
"conducted",
"randomized clinical trial to evaluate",
"efficacy",
"adding a novel adenosine receptor agonist",
"standard anti epileptic treatment",
"reducing",
"frequency",
"focal",
"found",
"patients taking",
"combination regimen",
"n",
"200",
"lower seizure frequency compared",
"patients taking",
"standard treatment alone",
"n",
"200",
"p",
"0.01",
"several participants taking",
"novel drug reported severe drowsiness",
"investigators administered",
"survey",
"combination treatment group",
"standard treatment group to evaluate",
"drowsiness interfered",
"daily functioning using",
"yes",
"questionnaire",
"Results",
"shown",
"Interference",
"daily functioning Yes",
"number of patients",
"number of patients",
"Combination treatment group",
"85 Standard",
"following statistical methods",
"most appropriate",
"assessing",
"statistical significance",
"results"
] | 00000000000000000229 |
39์ธ ๋จ์ฑ์ด ์ค๋ฅธ์ชฝ ์์์ ์ค๋ฅธ์ชฝ ์ด๊นจ๋ก ์งํ๋๋ ๊ฒฐ์ ์ฑ ํผ๋ถ ๋ณ๋ณ์ผ๋ก ๊ทํ์ ์ฌ๋ฌด์ค์ ๋ด์ํ์ต๋๋ค. ํ์๋ ํ์ฌ ๊ดด์ฌ์ฑ ๋ฐ ๊ถค์์ฑ์ธ ์ด๊ธฐ ๋ณ๋ณ์ด ๋ช ์ฃผ ์ ๊ด๋ชฉ์ ์ ๊ฑฐํ๋ค๊ฐ ์
์ ๋ถ์์ผ๋ก ์ธํด ๋ฐ์ํ๋ค๊ณ ๋ณด๊ณ ํฉ๋๋ค. ํ์๋ ํธํก๊ธฐ ๋๋ ์๋ง ์งํ์ ์ฆ์์ ๋ถ์ธํฉ๋๋ค. ๋ค์ ์ค ์ด ํ์์ ํผ๋ถ ๋ณ๋ณ ํจํด์ ๊ฐ์ฅ ์ ๋ํ๋ด๋ ๊ฒ์ ๋ฌด์์
๋๊น? | Ascending lymphangitis | {
"A": "Contact dermatitis",
"B": "Hematogenous dissemination",
"C": "Dermatophyte colonization",
"D": "Ascending lymphangitis"
} | step1 | D | [
"year old male presents",
"office",
"nodular skin lesions",
"progress",
"right hand",
"right shoulder",
"patient reports",
"initial lesion",
"currently necrotic",
"ulcerative",
"injury",
"received",
"weeding",
"couple weeks earlier",
"patient denies symptoms",
"respiratory",
"meningeal disease",
"following most likely characterizes",
"pattern",
"patients skin lesions"
] | 00000000000000000230 |
๊ณผ๊ฑฐ ๋ณ๋ ฅ์ด๋ ๊ฐ์กฑ๋ ฅ์ด ๋๋ ทํ์ง ์์ 17์ธ ๋ผํด ์๋ฉ๋ฆฌ์นด ์ฌ์ฑ ํ์๊ฐ ์ฌ๋ฌ ๋ง์ฑ ํผ๋ถ ๋ณ๋ณ์ ๋ํ ์ฐ๋ ค๋ฅผ ๊ฐ์ง๊ณ ์์๊ณผ์ ๋ด์ํ์ต๋๋ค. ๊ทธ๋
๋ ์ง๋ 2๋
๋์ ๊ฐ์ด๊ณผ ๋ณต๋ถ์ ์
์ ์์ ๋ฐ์ง์ด ์์๋ค๊ณ ์ธ๊ธํ์ต๋๋ค. ํ์์ 111/81 mm Hg, ๋งฅ๋ฐ์ ๋ถ๋น 82ํ, ํธํก์๋ ๋ถ๋น 16ํ, ์ฒด์จ์ 37.3ยฐC (99.1ยฐF)์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ, ๊ทธ๋
์ ๊ฐ์ด๊ณผ ๋ณต๋ถ์ ์๋ง์ ์ ์์์ฑ ๋ฐ์ ์ด ๋ํ๋ฌ์ต๋๋ค. ์๋ฐ๋ฅ์ด๋ ๋ฐ๋ฐ๋ฅ์๋ ๋ณ๋ณ์ด ๊ด์ฐฐ๋์ง ์์์ต๋๋ค. ์ง๋ฌธ์ ๋ฐ์ ๊ทธ๋
๋ ํ๋น์ ๋
ธ์ถ๋์์ ๋ ์ด๋ฌํ ๋ณ๋ณ์ด ๋ค๋ฅธ ํผ๋ถ์ฒ๋ผ ํ๋๋์ง ์๋๋ค๊ณ ์ง์ ํ์ต๋๋ค. ๋๋จธ์ง ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ์์ฑ์ด์์ต๋๋ค. ์ด๋ฌํ ๋ณ๋ณ์ ๊ฐ์ฅ ์ ๋ ฅํ ์์ธ์ ๋ฌด์์
๋๊น? | Malassezia yeast | {
"A": "Malassezia yeast",
"B": "Cutaneous T cell lymphoma",
"C": "TYR gene dysfunction in melanocytes",
"D": "Treponema pallidum infection"
} | step2&3 | A | [
"year old Latin American woman",
"significant past medical history",
"family history presents",
"pediatrician",
"concerns",
"long standing skin lesions",
"notes",
"light-colored rash",
"chest",
"abdomen",
"present",
"years",
"blood pressure",
"81 mm Hg",
"pulse",
"min",
"respiratory rate",
"min",
"temperature",
"3C",
"99",
"Physical examination reveals numerous hypopigmented macules",
"chest",
"abdomen",
"lesions",
"seen",
"palms",
"soles",
"questioned",
"states",
"lesions",
"not tan",
"rest",
"skin",
"exposed",
"sun",
"of",
"review",
"systems",
"negative",
"most likely cause",
"lesions"
] | 00000000000000000231 |
45์ธ ๋จ์ฑ์ด ์ฌํ ์ค์ฌ๋ฅผ ํธ์ํ๋ฉฐ ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ๊ทธ๋ ์ต๊ทผ ๋ฐฉ๊ธ๋ผ๋ฐ์ ์ถ์ฅ์ ๋ค๋
์์ต๋๋ค. ๊ท๊ตญ ํ, ๊ทธ๋ ํ๋ฃจ์ ์ฌ๋ฌ ๋ฒ์ ๋ฌฝ๊ณ ํ๋ณ์ ๊ฒฝํํ์ผ๋ฉฐ, ๋ณต๋ถ ๊ฒฝ๋ จ๊ณผ ๋๋๋ก ๋ฉ์ค๊บผ์๊ณผ ๊ตฌํ ๋ฅผ ๋๋ฐํ์ต๋๋ค. ๊ทธ์ ์ฒด์จ์ 101.7ยฐF (38.7ยฐC)์ด๊ณ , ํ์์ 100/60 mmHg, ๋งฅ๋ฐ์ 120/min, ํธํก์ 20/min์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์, ๊ทธ๋ ๋ณต๋ถ ์ ์ฒด์ ๊ฑธ์ณ ๊ฒฝ๋ฏธํ ์ํต์ ๋ณด์๊ณ , ๋ชจ์ธํ๊ด ์ฌ์ถฉ์ ์ง์ฐ ๋ฐ ์ ๋ง ๊ฑด์กฐ๋ฅผ ๋ณด์์ต๋๋ค. ๋๋ณ ๊ฒ์ฒด ๋ฐ ํ์ ๋๋ณ ๋ฐฐ์ ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ๋ณด๋ฅ ์ค์
๋๋ค. ์ด ํ์์ ํ์ฌ ์ํ๋ฅผ ์ ๋ฐํ๋ ๋ณ์์ฒด์ ์ํด ์์ฑ๋ ๋
์์ ์์ฉ ๊ธฐ์ ์ ๋ฌด์์
๋๊น? | Inhibition of 60S ribosomal subunit | {
"A": "elongation factor 2์ ADP-๋ฆฌ๋ณด์คํ",
"B": "guanylyl cyclase์ ์๊ทน",
"C": "G ๋จ๋ฐฑ์ง์ ADP-๋ฆฌ๋ณด์คํ",
"D": "60S ๋ฆฌ๋ณด์ ์๋จ์ ์ต์ "
} | step1 | D | [
"year old male presents",
"emergency room",
"severe diarrhea",
"recently returned",
"business trip",
"Bangladesh",
"Since returning",
"loose bloody",
"day",
"abdominal cramping",
"occasional nausea",
"vomiting",
"temperature",
"blood pressure",
"100 60 mmHg",
"pulse",
"min",
"respirations",
"20 min",
"examination",
"demonstrates mild tenderness",
"palpation",
"abdomen",
"delayed capillary refill",
"dry mucus membranes",
"Results",
"stool sample",
"subsequent stool culture",
"mechanism of action",
"toxin",
"pathogen responsible",
"patients current condition"
] | 00000000000000000232 |
80์ธ ์ฌ์ฑ์ด ์ธ๋ ์ง๋ฃ์์์ ์ข์ธก ์์์ ๋จ๋จํ ๊ฒฐ์ ์ฑ ๋ฉ์ด๋ฆฌ์ ๋ํ ํ๊ฐ๋ฅผ ๋ฐ๊ณ ์ ํฉ๋๋ค. ๋ณ๋ ฅ์ผ๋ก๋ ๊ณ ํ์, CABG ์์ ํ์ ๊ด์ ๋๋งฅ ์งํ, ํ์์ ๋ฐ๋ผ ์ผ๋ฐ์์ฝํ ์คํ
๋ก์ด๋ ํฌ๋ฆผ์ผ๋ก ์น๋ฃํ ์ง์ ํธํ ํ์ ์ด ์์ต๋๋ค. ์ฝ 5๊ฐ์ ์ ์ ์ฒ์ ๋ฉ์ด๋ฆฌ๋ฅผ ๋ฐ๊ฒฌํ์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ์ฒด์จ์ 37ยฐC (98.6ยฐF), ํ์์ 135/89 mm Hg, ๋งฅ๋ฐ์ 95/min, ํธํก์๋ 17/min์
๋๋ค. ์์๊ธฐ ๋ถ์ ๊ฒ์ฌ ๊ฒฐ๊ณผ ์ข์ธก ๋์์์ ์์ ๊ฒฐ์ ์ฑ ๋ฉ์ด๋ฆฌ๊ฐ ์๊ณ ๋์ ๋๋ ์ฐฐ๊ณผ์์ด ์์ง๋ง ํฐ์ ํ๋ผํฌ ๋ชจ์์ ๋ณ๋ณ์ ์์ต๋๋ค. ๋ค์์ผ๋ก ๊ฐ์ฅ ์ ์ ํ ๊ด๋ฆฌ ๋จ๊ณ๋ ๋ฌด์์
๋๊น? | Vulvar punch biopsy | {
"A": "HPV DNA testing",
"B": "Estrogen level measurement",
"C": "Pap smear",
"D": "Vulvar punch biopsy"
} | step2&3 | D | [
"80 year old woman",
"evaluation",
"outpatient clinic",
"firm nodular lump",
"left side",
"labia",
"medical history",
"notable",
"hypertension",
"coronary artery disease status post CABG",
"lichen sclerosus",
"vagina",
"treated with",
"over-the-counter steroid cream as needed",
"first",
"lump",
"months",
"physical examination",
"temperature",
"98",
"blood pressure",
"mm Hg",
"pulse",
"95 min",
"respiratory rate",
"min",
"Examination",
"genital area reveals",
"small nodular lump",
"left labium majus",
"visible excoriations",
"white plaque-like lesions",
"next best step",
"management"
] | 00000000000000000233 |
75์ธ ๋จ์ฑ์ด ์์ฌ ํ ํ๋ณ๊ณผ ๋ณตํต์ผ๋ก ์
์ํ์ต๋๋ค. ๋ด์๊ฒฝ ๊ฒ์ฌ์ CT ์ค์บ ๊ฒฐ๊ณผ ๋ด๋น ์์ฌ๋ ๋น์ฅ ๊ตด๊ณก ๋ถ์์ ํํ์ฑ ๋์ฅ์ผ์ผ๋ก ์ง๋จํ์ต๋๋ค. ๋ค์ ์ค ์ด๋ค ๊ฒ์ด ์ด ํ์์ ํํ์ฑ ๋์ฅ์ผ์ ์ ๋ฐํ ๊ฐ๋ฅ์ฑ์ด ๊ฐ์ฅ ๋์ต๋๊น? | Obstruction of the abdominal aorta following surgery | {
"A": "Increased splanchnic blood flow following a large meal",
"B": "Essential hypertension",
"C": "Obstruction of the abdominal aorta following surgery",
"D": "Juxtaglomerular cell tumor"
} | step1 | C | [
"75 year old male",
"hospitalized",
"bloody diarrhea",
"abdominal pain",
"meals",
"Endoscopic work-up",
"CT scan lead",
"attending physician to diagnose ischemic colitis",
"splenic flexure",
"following",
"most likely",
"patient",
"ischemic colitis"
] | 00000000000000000234 |
์๋ค์ ์ํ ์ถ์ฐํ ์ง ์ดํ ํ, ํ ์ด๋จธ๋๊ฐ ๋ด์ฆ์ฑ ๊ตฌํ ๋ก ์ธํด ์ ์๋ฅผ ์์ ์๊ธ์ค๋ก ๋ฐ๋ ค์๋ค. ์ ์์๋ ํ๋ณ์ ๋ฐฐ์ถํ์ง ๋ชปํ๊ณ ๋ณต๋ถ๊ฐ ํฝ๋ง๋์ด ์๋ค. ๊ทผ์ ๊ฒฐ์ฅ์ ๋ด์๊ฒฝ ์๊ฒ ๊ฒฐ๊ณผ ์ฅ๋ฒฝ์์ ๋ง์ด์ค๋ ์ ๊ฒฝ์ด๊ณผ ์์ฐ์ด๋ฐํ ์ ๊ฒฝ์ด์ด ๋ชจ๋ ๊ฒฐ์ฌ๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ๋ค. ๋ค์ ์ค ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ง๋จ์ ๋ฌด์์ธ๊ฐ? | Hirschsprungโs disease | {
"A": "Hirschsprung's disease",
"B": "Ileocecal intussusception",
"C": "Meckel's diverticulum",
"D": "Juvenile polyposis syndrome"
} | step1 | A | [
"Two days following",
"home birth",
"son",
"mother",
"infant",
"pediatric emergency room",
"bilious vomiting",
"unable to pass meconium",
"abdomen",
"distended",
"Endoscopic biopsy of",
"proximal colon demonstrates",
"absence",
"Auerbachs plexi",
"bowel wall",
"following",
"most likely diagnosis"
] | 00000000000000000235 |
49์ธ ๋จ์ฑ์ด 6๊ฐ์ ๋์ ์ฌํด์ง๋ ํผ๋ก๊ฐ๊ณผ ์ฑ์ ๊ฐํด๋ฅผ ํธ์ํ๋ฉฐ ์์ฌ๋ฅผ ์ฐพ์๋ค. ๊ทธ๋ ๋ํ ์์์ ๊ด์ ํต์ ํธ์ํ๋ค. ํ๋ ฅ ์งํ๋ ์ ์ ๋ฒ์ ๋ด์ ์๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ, ํผ๋ถ๋ ๊ทธ์๋ฆฐ ์ํ์๊ณ , ๊ณ ํ์ ์์๋ค. ์์์ ๋ ๋ฒ์งธ์ ์ธ ๋ฒ์งธ ์ค์์ง๊ด์ ์ ์ด์ง ์ ์ํต์ด ์์ผ๋ฉฐ, ์ด๋ ๋ฒ์๊ฐ ์ ํ์ ์ด๋ค. ๊ฐ์ ์ฐ์ธก ๋๊ณจ ์๋ 2~3cm์์ ์ด์ง๋๋ค. ๊ฐ ์๊ฒ ํ๋ณธ์ ์กฐ์ง๋ณ๋ฆฌํ์ ๊ฒ์ฌ ๊ฒฐ๊ณผ, ํ๋ฌ์์ ๋ธ๋ฃจ ์ผ์์ ์ผ์๋๋ ์ธํฌ ๋ด ๋ฌผ์ง์ด ๋ํ๋ฌ๋ค. ์ด ํ์๋ ๋ค์ ํฉ๋ณ์ฆ ์ค ์ด๋ค ๊ฒ์ ๋ฐ๋ณํ ์ํ์ด ๊ฐ์ฅ ํด๊น? | Restrictive cardiomyopathy | {
"A": "๋์ฅ์",
"B": "์ ํ์ฑ ์ฌ๊ทผ๋ณ์ฆ",
"C": "์ท์ฅ ์ ์์ข
",
"D": "๋นํธ์งํจ ๋ฆผํ์ข
"
} | step1 | B | [
"year old man",
"physician",
"month history",
"increasing fatigue",
"reduced libido",
"joint pain",
"hands",
"vital signs",
"normal",
"Physical examination shows tanned skin",
"small testes",
"second",
"third",
"joints of",
"hands",
"tender",
"palpation",
"range of motion",
"limited",
"liver",
"palpated 2",
"3 cm",
"right costal margin",
"Histopathologic examination of",
"liver biopsy specimen shows intracellular material",
"stains",
"Prussian blue",
"patient",
"greatest risk",
"following complications"
] | 00000000000000000236 |
์ผ๋ฐ ์ธ๊ณผ ์ธํด์ ์ฌ๋ฐ์ฑ ๊ฒ์ค์ผ ์น๋ฃ๋ฅผ ์ํด ์ฑ๊ณต์ ์ธ sigmoidectomy๋ฅผ ๋ฐ์ 59์ธ ๋จ์ฑ์ ๋ณ์์ผ๋ก ํธ์ถ๋์์ต๋๋ค. ํ์์ ๊ฐํธ์ฌ๋ ๋ฐฉ๊ธ 38.7 C์ ์ฒด์จ์ ๊ธฐ๋กํ์ผ๋ฉฐ ํ์๊ฐ ์คํ์ ํธ์ํ๋ค๊ณ ๋งํฉ๋๋ค. ์์ ์ 8์๊ฐ ์ ์ ์๋ฃ๋์์ผ๋ฉฐ ์ถ์ ํ์ก ์์ค๋ 1,700 mL์ ๊ด๋ฒ์ํ ์ถํ๋ก ์ธํด ๋ณต์กํ์ต๋๋ค. ํค๋ชจ๊ธ๋ก๋น ์์น๊ฐ 5.9 g/dL๋ก ๋ํ๋ ํ ์์ ํ ๋นํ์ด ์ง๋จ๋์๊ณ , ๋์ถ ์ ํ๊ตฌ 2๋จ์๋ฅผ ์ฒ๋ฐฉํ์ฌ 90๋ถ ์ ์ ์ํ์ ์์ํ์ต๋๋ค. ํ์์ ํ๋ ฅ ์งํ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค. T 38.7 C, HR 88, BP 138/77, RR 18, SpO2 98%. ์ ์ฒด ๊ฒ์ฌ์์๋ ์ด์์ด ๋ฐ๊ฒฌ๋์ง ์์์ต๋๋ค. ์ํ์ ์ฆ์ ์ค๋จํ ํ, ์ด ํ์ ์ํ์ ๋ํ ์ต์ ์ ๊ด๋ฆฌ๋ ๋ค์ ์ค ๋ฌด์์
๋๊น? | Monitor patient and administer acetaminophen | {
"A": "Monitor patient and administer acetaminophen",
"B": "Prescribe diphenhydramine",
"C": "Start supplemental oxygen by nasal cannula",
"D": "Initiate broad spectrum antibiotics"
} | step2&3 | A | [
"general surgery intern",
"paged",
"59 year old male",
"successful sigmoidectomy",
"treatment",
"recurrent diverticulitis",
"patient's nurse",
"recorded",
"temperature",
"relates",
"patient",
"chills",
"surgery",
"completed 8 hours",
"complicated",
"extensive bleeding",
"estimated blood loss of 1",
"mL",
"Post-operative anemia",
"diagnosed",
"a hemoglobin",
"5.9 g/dL",
"found",
"2 units",
"packed red blood cells",
"ordered",
"transfusion",
"initiated 90 minutes",
"patient's vital signs",
"follows",
"T",
"88",
"BP",
"RR",
"98",
"Physical examination",
"not show",
"abnormalities",
"immediately stopping",
"transfusion",
"following",
"best management",
"patient's"
] | 00000000000000000237 |
22์ธ ๋จ์ฑ์ด ๋ถ์ ์ฆ์ธ๋ก ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ํ์๋ ๋งค์ฐ ๋ถ์ํ๋ฉฐ, ์ํ์์ ๋ณต์ฉํ๋ ๋ถ์ ๊ด๋ จ ์ฝ๋ฌผ์ ๋ณต์ฉํ์ง ๋ชปํ๋ค๊ณ ์ง์ ํฉ๋๋ค. ํ์๋ ์ํ์์ ๋ณต์ฉํ๋ ์ฝ๋ฌผ์ ํฌ์ฌ๋ฅผ ์์ฒญํ๊ณ ์์ต๋๋ค. ํ์๋ ๊ณผ๊ฑฐ ๋ถ์ ๋ฐ ์ฐ์ธ์ฆ ๋ณ๋ ฅ์ ๊ฐ์ง๊ณ ์์ต๋๋ค. ํ์ฌ ๋ณต์ฉ ์ค์ธ ์ฝ๋ฌผ์ ํด๋ก๋์ ํ, ์๋ฏธํธ๋ฆฝํธ๋ฆฐ, ๋ก๋ผ์ ํ์
๋๋ค. ํนํ, ํ์๋ ํ์ฌ ์ง๋ฃ๋ฅผ ์ ๊ณตํ๋ ์ฌ๋ฌ ๋ช
์ ์ ์ ๊ณผ ์ง๋ฃ ์ ๊ณต์๋ฅผ ๋๊ณ ์์ต๋๋ค. ์ฒด์จ์ 99.2ยฐF (37.3ยฐC)์ด๊ณ , ํ์์ 130/85 mmHg์ด๋ฉฐ, ๋งฅ๋ฐ์ 112/min, ํธํก์๋ 22/min, ์ค๋ด ๊ณต๊ธฐ ์ค ์ฐ์ ํฌํ๋๋ 100%์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ, ์๊ธ์ค์ ๋จธ๋ฌด๋ ๋์ ๋์ฑ ํผ๋์ค๋ฌ์์ง๋ ๋ถ์ํ๊ณ ๋์ ํ๋ฆฌ๋ฉฐ ๋จ๋ฆฌ๋ ์ ์ ๋จ์ฑ์ด ๊ด์ฐฐ๋์์ต๋๋ค. ์ด ํ์์๊ฒ ๋ค์ ์ค ์ด๋ค ๊ฒ์ ํฌ์ฌํด์ผ ํ ๊น์? | Diazepam | {
"A": "Diazepam",
"B": "Midazolam",
"C": "Sodium bicarbonate",
"D": "Supportive therapy and monitoring"
} | step2&3 | A | [
"year old man presents",
"emergency department",
"anxiety",
"patient states",
"very anxious",
"not",
"able to take",
"home anxiety medications",
"requesting to",
"home medications administered",
"patient",
"past medical anxiety",
"depression",
"current medications include clonazepam",
"amitriptyline",
"lorazepam",
"patient",
"multiple psychiatric providers",
"currently care",
"temperature",
"99",
"3C",
"blood pressure",
"85 mmHg",
"pulse",
"min",
"respirations",
"min",
"oxygen saturation",
"100",
"room air",
"Physical exam",
"notable",
"anxious",
"sweating",
"tremulous young man",
"more confused",
"emergency department",
"following",
"given",
"patient"
] | 00000000000000000238 |
๊ฐ๋ฐ ๋์๊ตญ ์ฌํ์์ ๋์์จ 18์ธ ์ฌ์ฑ์ด ์ค์ฌ์ ๋ณต๋ถ ํต์ฆ์ ํธ์ํ๋ฉฐ ๋ด์ํ์ต๋๋ค. ๋๋ณ์ ํ๋ฏธ๊ฒฝ ๊ฒ์ฌ ๊ฒฐ๊ณผ RBC์ WBC์ ์กด์ฌ๊ฐ ํ์ธ๋์์ต๋๋ค. ํ์๋ ๋ฐฉ๋ฌธํ ์ง์ญ์ ์ด์
ํ ํ์๋ ์์ ์ํ๋ฅผ ๋ณด๊ณ ํ์ต๋๋ค. ์์ฌ๋ ์ธ๊ท ๊ฐ์ผ์ ์์ฌํ๊ณ ๋ฐฐ์ ๊ฒฐ๊ณผ lactose๋ฅผ ๋ฐํจ์ํค์ง ์๋ Gram-negative rods๊ฐ ๋ฐ๊ฒฌ๋์์ต๋๋ค. ์ธ๊ท ๋
์์ A subunit์ ๋ค์๊ณผ ๊ฐ์ด ์์ฉํฉ๋๋ค. | Inhibit the 60S ribosome | {
"A": "60S ribosome ์ต์ ",
"B": "์ ํ๊ตฌ ์ฉํด",
"C": "์๊ท ์์ฉ ๋ฐฉ์ง",
"D": "์๋
์ค ๋ง๋จ์์ ACh์ ์ธํฌ์ธ๋ฐฐ์ถ ์ต์ "
} | step1 | A | [
"year old female returning",
"trip",
"developing country presents",
"diarrhea",
"pain",
"abdominal region",
"Microscopic evaluation",
"stool reveals",
"presence",
"RBC's",
"WBC's",
"patient reports poor sewage sanitation",
"region",
"visited",
"physician suspects",
"bacterial infection",
"culture reveals Gram-negative rods",
"non lactose",
"subunit",
"bacteria's toxin acts to"
] | 00000000000000000239 |
์ต๊ทผ ์ํ์ฑ ๊ถค์ ์งํ์ผ๋ก ์ง๋จ๋ฐ๊ณ ๊ฒฝ๊ตฌ์ฉ ์์ฑ์ ํํ ์ต์ ์ ๋ฅผ ํ๋ฃจ ๋ ๋ฒ ๋ณต์ฉ ์ค์ธ 51์ธ ๋จ์ฑ์ด 2์๊ฐ ์ด๋ด์ ๊ฐ์๊ธฐ ์์๋ ๊ธ์ฑ ๋ณตํต์ ํธ์ํ๋ฉฐ ์๊ธ ์น๋ฃ ์ผํฐ์ ๋ด์ํ์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ๋ณต๋ถ๋ ๊ฒฝ๋ฏธํ๊ฒ ํฝ์ฐฝ๋์ด ์๊ณ , ์ด์ง ์ ์ ๋ฐ์ ์ผ๋ก ์ํต์ด ์์ผ๋ฉฐ, ๋ฐ๋ ์ํต ์์ฑ์ผ๋ก ๋ํ๋ฌ์ต๋๋ค. ๋ค์ ์ต์
์ ๊ณ ๋ คํ ๋, ํ์ ๊ด๋ฆฌ์ ๋ค์์ผ๋ก ๊ฐ์ฅ ์ ์ ํ ๋จ๊ณ๋ ๋ฌด์์
๋๊น? | Urgent CT abdomen and pelvis | {
"A": "Abdominal radiographs",
"B": "Urgent CT abdomen and pelvis",
"C": "H. pylori testing",
"D": "Serum gastrin level"
} | step2&3 | B | [
"year old man",
"recent diagnosis",
"peptic ulcer disease currently treated with",
"oral proton pump inhibitor twice daily presents",
"urgent care center",
"acute abdominal pain",
"began",
"hours",
"physical exam",
"find",
"abdomen to",
"mildly distended",
"tender",
"palpation",
"positive",
"rebound tenderness",
"Given",
"following options",
"next best step",
"patient management"
] | 00000000000000000240 |
31์ธ ๋จ์ฑ์ด ์ง์ญ ์๋ฃํ์ ์์ ์๋๋ค๊ณผ์ ๋คํผ ํ ์๊ธ์ค๋ก ๋ด์ํ์ต๋๋ค. ๊ทธ๋ ๋ณ์ ์ง์์๊ฒ ๊ณต๊ฒฉ์ ์ผ๋ก ํ๋ํ๊ณ ์์ผ๋ฉฐ ์กด์ฌํ์ง ์๋ ์ฌ๋๋ค์๊ฒ ๋งํ๋ ๊ฒ์ฒ๋ผ ๋ณด์
๋๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ, ๋น๋งฅ ๋ฐ ๋ฐํ ์ฆ์ธ๋ฅผ ๋ณด์
๋๋ค. ์ํ ๋ฐ ์์ง ์์ง์ด ๊ด์ฐฐ๋ฉ๋๋ค. ํ์๋ ๊ฒฐ๊ตญ ์ ๋
์ผ์ฐ ๋ถ๋ฒ ์ฝ๋ฌผ์ ๋ณต์ฉํ๋ค๊ณ ์ธ์ ํฉ๋๋ค. ๋ค์ ์ค ์ด ํ์๊ฐ ๋ณต์ฉํ ๋ฌผ์ง๊ณผ ๊ฐ์ฅ ์ผ์นํ๋ ์์ฉ ๊ธฐ์ ์ ๋ฌด์์
๋๊น? | NMDA receptor antagonist | {
"A": "Adenosine antagonist",
"B": "Mu receptor agonist",
"C": "GABA agonist",
"D": "NMDA receptor antagonist"
} | step1 | D | [
"31 year old male presents",
"emergency room following",
"altercation",
"local grocery store",
"acting",
"hospital staff",
"appears to",
"speaking",
"non existent individuals",
"examination",
"tachycardic",
"diaphoretic",
"Horizontal",
"vertical nystagmus",
"noted",
"patient",
"admits",
"illegal substance earlier",
"evening",
"of",
"following mechanisms",
"action",
"most consistent with",
"substance",
"patient took"
] | 00000000000000000241 |
29์ธ ์ฌ์ฑ์ด ์๊ณผ ๋ฌด๋ฆ์ ํต์ฆ ๋ฐ ๊ฒฝ์ง์ ํธ์ํ๋ฉฐ ์ฃผ์น์์๊ฒ ๋ด์ํ์ต๋๋ค. ๊ทธ๋
๋ ๊ฒฝ์ง์ด ์์นจ์ ๋ ์ฌํ๊ณ ํ๋ฃจ ์ข
์ผ ๋์์ง๋ ๊ฒ ๊ฐ๋ค๊ณ ๋ณด๊ณ ํฉ๋๋ค. ๋ค๋ฅธ ์ ์์๋ ๊ฑด๊ฐํ๋ฉฐ ์ต๊ทผ ์ง๋ณ์ ๋ถ์ธํฉ๋๋ค. ๊ทธ๋
๋ ์คํฌ์ธ ๋ฅผ ํ์ง ์์ต๋๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ, ๊ทธ๋
์ ์ค์์ง์ (MCP) ๋ฐ ๊ทผ์ ์ง์ ๊ฐ(PIP) ๊ด์ ์ด ๋ถ๊ณ ํ๋ฐ์ฑ์ด ์์ต๋๋ค. ๊ทธ๋
์ ์์ ์ง์ ๊ฐ(DIP) ๊ด์ ์ ์ ์์ผ๋ก ๋ณด์
๋๋ค. ๊ทธ๋
๋ ์์ชฝ ๋ฌด๋ฆ์์ ์๋ ๋ฐ ๋ฅ๋ ์ด๋ ๋ฒ์ ๋ชจ๋์์ ํต์ฆ์ ๋ณด์
๋๋ค. ํ์ฒญ ๋ถ์ ๊ฒฐ๊ณผ anti-cyclic citrullinated peptide antibodies์ ๋์ ์ญ๊ฐ๊ฐ ๋ํ๋ฌ์ต๋๋ค. ๋ค์ ์ค ์ด๋ค ๊ณผ์ ์ด ์ด ํ์์ ์ํ์ ๊ทผ๋ณธ ์์ธ์
๋๊น? | Synovial hypertrophy and pannus formation | {
"A": "๊ด์ ๋ด ๊ณต๊ฐ์์ monosodium urate ๊ฒฐ์ ์ ์นจ์ ",
"B": "๊ด์ ํ๋ฉด์ ๊ฐ์ผ ํ ์ผ์ฆ",
"C": "๊ด์ ์ฐ๊ณจ์ ํดํ์ฑ ์
ํ",
"D": "ํ๋ง ๋น๋ ๋ฐ ํ๋์ค ํ์ฑ"
} | step1 | D | [
"29 year old female presents",
"primary care provider",
"pain",
"stiffness",
"hands",
"knees",
"reports",
"stiffness",
"worse",
"morning",
"appears to",
"better",
"day",
"healthy",
"denies",
"recent illness",
"not play sports",
"examination",
"metacarpal phalangeal",
"proximal interphalangeal",
"joints",
"swollen",
"erythematous",
"distal interphalangeal",
"joints appear normal",
"exhibits pain",
"passive",
"active range of motion",
"knees",
"Serological analysis reveals high titers",
"anti-cyclic citrullinated peptide antibodies",
"following processes",
"patients condition"
] | 00000000000000000242 |
28์ธ ๋จ์ฑ์ด ์ฌํ ๋ณตํต์ ํธ์ํ๋ฉฐ ๋ด์ํ์ฌ ์ถฉ์๋๊ธฐ์ผ์ผ๋ก ์ง๋จ๋ฐ์์ต๋๋ค. ๊ทธ๋ ์๊ธ ์ถฉ์ ์ ์ ์ ์ ๋ฐ์์ต๋๋ค. ์์ ์ค ํ์๋ ๋๋์ ์ง์์ ์ธ ์ถํ์ ๋ณด์ฌ ์ํ์ด ํ์ํ์ต๋๋ค. ์์ ์ ๊ฒ์ฌ ๊ฒฐ๊ณผ, ์ ์์ ์ธ ์ถํ ์๊ฐ, ์ ์์ ์ธ ํ๋กํธ๋กฌ๋น ์๊ฐ(PT), INR 1.0, ์ ์ ํ์ํ ์์น๋ฅผ ๋ณด์์ต๋๋ค. ์์ ํ, ํ์๋ ์์ ์ค ํฉ๋ณ์ฆ์ ๋ํด ๋ฃ๊ณ , ์ ์ ์๋ ์ถํ ์งํ์ ๊ฐ์กฑ๋ ฅ์ ์ธ๊ธํ๋ ๊ฒ์ ์์๋ค๊ณ ํ์ํ์ต๋๋ค. ์์ ํ ๊ฒ์ฌ ๊ฒฐ๊ณผ, ์ฐ์ฅ๋ ๋ถ๋ถ ํธ๋กฌ๋ณดํ๋ผ์คํด ์๊ฐ(PTT)์ด ๋ํ๋ฌ์ต๋๋ค. ์ด ํ์์๊ฒ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ง๋จ์ ๋ฌด์์
๋๊น? | Hemophilia A | {
"A": "ํ์ฐ๋ณ A",
"B": "๋ฒ ๋ฅด๋๋ฅด-์ ๋ฆฌ์ ์ฆํ๊ตฐ",
"C": "๊ธ๋์ธ ๋ง ํ์ํ ๋ฌด๋ ฅ์ฆ",
"D": "ํ์ ์ฑ ํ์ํ ๊ฐ์์ฑ ์๋ฐ๋ณ"
} | step2&3 | A | [
"year old man presents",
"severe abdominal",
"diagnosed",
"appendicitis",
"taken",
"emergent appendectomy",
"procedure",
"patient",
"massive",
"persistent bleeding",
"blood transfusion",
"preoperative laboratory studies showed",
"normal bleeding time",
"normal prothrombin time",
"INR",
"1.0",
"normal platelet count",
"patient",
"complications",
"surgery",
"recalls",
"forgot to",
"family history of",
"unknown bleeding disorder",
"postoperative laboratory tests reveal",
"prolonged partial thromboplastin time",
"following",
"most likely diagnosis",
"patient"
] | 00000000000000000243 |
11์ธ ์ฌ์๊ฐ ๊ณ ์ด, ๋ํต ๋ฐ ๋ฉ์ค๊บผ์์ 3์ผ ๋์ ํธ์ํ์ฌ ์๊ธ์ค๋ก ์ด์ก๋์์ต๋๋ค. ๊ทธ๋
๋ ๋ํต์ ์
ํ์ํค๊ธฐ ๋๋ฌธ์ ๋น์ ์ณ๋ค๋ณด๋ ๊ฒ์ ํผํฉ๋๋ค. ๊ทธ๋
๋ ๊ธ์ฑ ๋ฆผํ๋ชจ๊ตฌ์ฑ ๋ฐฑํ๋ณ์ ์๊ณ ์์ผ๋ฉฐ ๋ง์ง๋ง ํํ ์๋ฒ ์ฃผ๊ธฐ๋ 2์ฃผ ์ ์ด์์ต๋๋ค. ๊ทธ๋
๋ ๊ธฐ๋ฉด ์ํ๋ก ๋ณด์
๋๋ค. ๊ทธ๋
์ ์ฒด์จ์ 40.1ยฐC (104.2ยฐF)์ด๊ณ , ๋งฅ๋ฐ์ 131ํ/๋ถ, ํ์์ 100/60 mm Hg์
๋๋ค. ์ง์ฐฐ ๊ฒฐ๊ณผ ๋ชฉ์ด ๋ปฃ๋ปฃํฉ๋๋ค. ๋๊ณต์ ๋์ผํ๋ฉฐ ๋น์ ๋ฐ์ํฉ๋๋ค. ๋ชฉ ๊ตด๊ณก์ ๋ฌด๋ฆ๊ณผ ์๋ฉ์ด์ ๊ตด๊ณก์ ์ ๋ฐํฉ๋๋ค. ๊ทผ๋ ฅ์ ์ค๋ฅธ์ชฝ ์์ง์์ ๊ฐ์๋์์ต๋๋ค. ์ฌ๋ถ๊ฑด ๋ฐ์ฌ๋ ์์ชฝ ๋ชจ๋ 2+์
๋๋ค. ๊ฐ๊ฐ์ ์จ์ ํฉ๋๋ค. ์ธ์๊ทผ ์ด๋์ ์ ์์
๋๋ค. ๋ ์ธํธ์ ํ์ก ๋ฐฐ์์ ์ค์ํฉ๋๋ค. ๋ค์ ์ค ๊ด๋ฆฌ์ ์์ด ๊ฐ์ฅ ์ ์ ํ ๋ค์ ๋จ๊ณ๋ ๋ฌด์์
๋๊น? | Antibiotic therapy | {
"A": "CT scan of the head",
"B": "MRI of the brain",
"C": "Antibiotic therapy",
"D": "Lumbar puncture"
} | step2&3 | C | [
"year old girl",
"brought",
"emergency department",
"high-grade fever",
"headache",
"nausea",
"3 days",
"looking",
"light source",
"aggravates",
"headache",
"acute lymphoblastic leukemia",
"last chemotherapy cycle",
"2 weeks",
"appears lethargic",
"temperature",
"40",
"pulse",
"min",
"blood pressure",
"100 60 mm Hg",
"Examination shows",
"stiff neck",
"pupils",
"equal",
"reactive to light",
"Neck flexion results in flexion of",
"knee",
"hip",
"Muscle",
"decreased",
"right upper extremity",
"Deep tendon reflexes",
"2",
"Sensation",
"intact",
"Extraocular movements",
"normal",
"Two sets of blood cultures",
"obtained",
"following",
"most appropriate next step",
"management"
] | 00000000000000000244 |
49์ธ ๋จ์ฑ์ด ์ง๋ ํ ๋ฌ ๋์ ํผ๋ก๊ฐ๊ณผ ๊ฐ๋ ์ด์ด ๋๋ ์ฆ์์ ์ฃผ ํธ์ํ๋ฉฐ ์๋ก์ด ์ฃผ์น์์๊ฒ ์ง๋ฃ๋ฅผ ๋ฐ์ต๋๋ค. ์ด๋ฌํ ์ฆ์๋ค์ด ์ง์
์ ์ํฅ์ ๋ฏธ์น๊ธฐ ์์ํ์ฌ ์น๋ฃ๋ฅผ ์ํฉ๋๋ค. ์์ฌ๋ ํ์ค ๋์ฌ ๊ฒ์ฌ๋ฅผ ์ค์ํ๊ณ , AST์ ALT๊ฐ ์์น๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ์ต๋๋ค. ํ์๋ ๊ทธ ํ ๊ฐ์ผ ๋ฐ์ด๋ฌ์ค ๊ฒ์ฌ๋ฅผ ๋ฐ์์ต๋๋ค. Cํ ๊ฐ์ผ ์์ฑ์ผ๋ก ํ๋ช
๋์์ต๋๋ค. ํ์์ ์์ฌ๋ ์น๋ฃ ์ต์
์ ๋ํด ๋
ผ์ํ๊ณ ํ๊ธธํ ์ธํฐํ๋ก ๊ณผ ๊ฒฝ๊ตฌ ๋ฆฌ๋ฐ๋น๋ฆฐ์ ๋์ํ์ต๋๋ค. ๋ฆฌ๋ฐ๋น๋ฆฐ ๋ณต์ฉ ์ค ๊ฐ์ฅ ๋ฐ์ํ ๊ฐ๋ฅ์ฑ์ด ๋์ ๋ถ์์ฉ์ ๋ฌด์์
๋๊น? | Hemolytic anemia | {
"A": "์ฉํ์ฑ ๋นํ",
"B": "์ฝ๋ฌผ ๊ด๋ จ ๋ฃจํธ์ค",
"C": "๊ฐ์์ ๊ธฐ๋ฅ ํญ์ง์ฆ",
"D": "๋ฐ์ง"
} | step1 | A | [
"year old man presents",
"new primary care provider",
"fatigue",
"occasional fever",
"month",
"symptoms",
"starting to affect",
"job",
"treatment",
"physician runs",
"standard metabolic panel",
"shows elevated AST",
"ALT",
"patient",
"then tested",
"hepatitis viruses",
"hepatitis",
"positive",
"patient",
"doctor discuss treatment options",
"agree",
"interferon",
"oral ribavirin",
"side-effect",
"most likely",
"taking",
"ribavirin"
] | 00000000000000000245 |
45์ธ์ ์ด๋ฏผ์๊ฐ ์๋ํ์ง ์์ ์ฒด์ค ๊ฐ์, ์๋ฉด ์ค ๋คํ์ฆ, ๊ทธ๋ฆฌ๊ณ ์ง์์ ์ธ ๊ธฐ์นจ์ ํธ์ํ๋ฉฐ ๋ด์ํ์ต๋๋ค. ํ์๋ ์ด๋ฌํ ์ฆ์์ด ๊ฝค ์ค๋ซ๋์ ์ง์๋์๋ค๊ณ ๋งํฉ๋๋ค. ์์ ๊ฒ์ฌ ๊ฒฐ๊ณผ, ์์ฝ์ ๋ค์์ granuloma๊ฐ ๊ด์ฐฐ๋์์ต๋๋ค. ์ด๋ฌํ apical granuloma์ ์น์ฆ ๋ชจ์์ ๊ดด์ฌ ์ค์ฌ๋ถ๋ฅผ ๊ฐ์ง๊ณ ์๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ์ต๋๋ค. ๊ดด์ฌ ๋ถ์๋ฅผ ๋๋ฌ์ธ๊ณ ์๋ ๊ฒ์ ์
์ ์์ ์ธํฌ์ง์ ๊ฐ์ง ํฐ ์ธํฌ๋ค์
๋๋ค. ๋ค์ ํ๋ฉด ๋ง์ปค ์ค, ์ด๋ฌํ ์ธํฌ์ ํน์ด์ ์ธ ๊ฒ์ ๋ฌด์์
๋๊น? | CD14 | {
"A": "CD8",
"B": "CD4",
"C": "CD3",
"D": "CD14"
} | step1 | D | [
"year old immigrant presents",
"unintentional weight loss",
"sleep hyperhidrosis",
"persistent cough",
"symptoms",
"present",
"time",
"imaging",
"granulomas",
"upper lobes",
"present",
"noted",
"apical granulomas",
"centers",
"necrosis",
"appear cheese",
"appearance",
"Encircling",
"area",
"necrosis",
"large cells",
"cytoplasms pale",
"color",
"following surface markers",
"one",
"specific",
"cells"
] | 00000000000000000246 |
27์ธ ์ฌ์ฑ์ด ์ง๋์ฃผ๋ถํฐ ์์๋ ๋ฐ์ด๊ณผ ์ฌํ ์ข์ธก ๋ฌด๋ฆ ํต์ฆ์ผ๋ก ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ํด๋น ๋ถ์์ ์ธ์์ด๋ ๋ถ์์ ์
์ ์ ์ด ์์ผ๋ฉฐ, ์ต๊ทผ์ ์ฌํ์ ๊ฐ๊ฑฐ๋ ์ผ์ธ ํ๋์ ์ฐธ์ฌํ ์ ๋ ์์ต๋๋ค. ๊ทธ๋
๋ ํ ๋ช
์ ๋จ์ฑ ํํธ๋์ ์ฑ์ ์ผ๋ก ํ๋์ ์ด๋ฉฐ, ์ฝ๋์ ๋ถ๊ท์น์ ์ผ๋ก ์ฌ์ฉํฉ๋๋ค. ๊ทธ๋
๋ ์ํ ๋ณด์
๋๋ค. ์ฒด์จ์ 38ยฐC(100.4ยฐF), ๋งฅ๋ฐ์ 98ํ/๋ถ, ํธํก์๋ 17ํ/๋ถ, ํ์์ 106/72 mm Hg์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ, ์์ชฝ ๋ฐ๋ชฉ๊ณผ ๋ฐ๋ฑ ๋ฐ ๋ฐ๋ฐ๋ฅ์ ๋ค์์ ๋ฌดํต์ฑ ๋ํฌ์ฑ ๋ณ๋ณ์ด ์์ผ๋ฉฐ, ๋ถ์ด์ค๋ฅด๊ณ ํ๋ฐ์ฑ์ด๋ฉฐ ๊ทน์ฌํ๊ฒ ์ํต์ด ์๋ ์ข์ธก ๋ฌด๋ฆ์ด ๊ด์ฐฐ๋ฉ๋๋ค. ์๋ชฉ ๋ํ ๊ฒฝ๋ฏธํ๊ฒ ๋ถ์ด ์๊ณ ์ํต์ด ์์ผ๋ฉฐ, ์ ์ ์ ํต์ฆ์ด ์์ต๋๋ค. ๋ฌด๋ฆ X-ray ์ดฌ์ ๊ฒฐ๊ณผ ์กฐ์ง ๋ถ์ข
์ด ๋ํ๋ฉ๋๋ค. ๋ฌด๋ฆ ๊ด์ ์ฒ์ ๊ฒฐ๊ณผ ๋
ธ๋์ ํ๋์ฑ ์ก์ฒด๊ฐ ํ์ธ๋ฉ๋๋ค. Gram ์ผ์ ๊ฒฐ๊ณผ๋ ์์ฑ์
๋๋ค. ํ์ก ๋ถ์ ๊ฒฐ๊ณผ ๋ฐฑํ๊ตฌ ์๋ 58,000/mm3์ด๋ฉฐ, ์ค์ฑ๊ตฌ๋ 93%, ๊ฒฐ์ ์ฒด๋ ์์ต๋๋ค. ๋ค์ ์ค ๊ฐ์ฅ ์ ์ ํ ์ฝ๋ฌผ ์๋ฒ์ ๋ฌด์์
๋๊น? | Intramuscular ceftriaxone and oral azithromycin | {
"A": "Oral penicillin V",
"B": "Intramuscular ceftriaxone and oral azithromycin",
"C": "Oral doxycycline",
"D": "Intramuscular ceftriaxone"
} | step2&3 | B | [
"27 year old woman",
"emergency room",
"fever",
"severe left knee pain",
"past week",
"not sustained",
"trauma",
"injury",
"area",
"traveled",
"taken part",
"outdoor activities",
"recent past",
"sexually active",
"one male partner",
"use condoms",
"appears ill",
"temperature",
"100 4F",
"pulse",
"98 min",
"respirations",
"min",
"blood pressure",
"72 mm Hg",
"Physical examination shows multiple painless pustular lesions",
"ankles",
"dorsum",
"soles of",
"feet",
"swollen",
"erythematous",
"tender left",
"wrists",
"mildly edematous",
"tender",
"pain",
"extension",
"X-ray",
"knees shows tissue swelling",
"Arthrocentesis of",
"knee shows yellow purulent fluid",
"Gram stain",
"negative",
"Analysis",
"synovial fluid shows",
"leukocyte count",
"58",
"mm3",
"neutrophils",
"crystals",
"following",
"most appropriate pharmacotherapy"
] | 00000000000000000247 |
30์ธ ๋จ์ฑ์ด ์ง๋ 2์ผ ๋์ ์์ ๋ถ์ ๋ชปํจ๊ณผ ์๊ฑฐ๋ ๋์ง ๋ชปํ๋ ์ฆ์์ผ๋ก ๋ด์ํ์ต๋๋ค. ๊ณผ๊ฑฐ ๋ณ๋ ฅ์ 3์ฃผ ์ ์ ์ ์ ๋ถ์ด๋ณ์ผ๋ก ์ง๋จ๋ฐ์์ผ๋ฉฐ, ์ฝ๋ฌผ๋ก ๊ด๋ฆฌ๋ฐ๊ณ ์์ต๋๋ค. ํ๋ ฅ ์งํ๋ ํ์ 140/90 mm Hg, ๋งฅ๋ฐ 96/min์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ํ์๋ ์์ ๋ถ์ ๋ชปํ๊ณ ๋ถ์ํดํ์ง๋ง, ์ง๋จ๋ ฅ์ ์ํธํฉ๋๋ค. ์ด ํ์์๊ฒ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ง๋จ์ ๋ฌด์์
๋๊น? | Akathisia | {
"A": "์ ์ ๋ณ์ ์ด์กฐ",
"B": "๋ณธํ์ฑ ๋จ๋ฆผ",
"C": "์ฝ๋ฌผ ์ ๋ฐ ํํจ์จ์ฆ",
"D": "์ ์ข๋ถ๋ฅ์ฆ"
} | step1 | D | [
"30 year old man presents",
"restlessness",
"sit",
"past",
"days",
"medical history",
"significant",
"schizophrenia",
"diagnosed 3 weeks",
"managed",
"Vital signs",
"blood pressure",
"90 mm Hg",
"pulse",
"96 min",
"physical examination",
"patient",
"fidgety",
"anxious",
"well oriented",
"following",
"most likely diagnosis",
"patient"
] | 00000000000000000248 |
์ด์ ์ ๊ฐ์ธํฌ ๊ฐ์ผ ์คํ์์ ์์กด ๊ฐ๋ฅํ HDV ๋ฐ์ด๋ฌ์ค ์
์๋ HBV์์ ๋์ ๊ฐ์ผ์ด ์กด์ฌํ๋ ๊ฒฝ์ฐ์๋ง ์์ฑ๋๋ค๋ ๊ฒ์ด ๋ฐํ์ก์ต๋๋ค. ์์กด ๊ฐ๋ฅํ HDV ๋ฐ์ด๋ฌ์ค ์
์ ์์ฐ์ ํ์ํ HBV ์
์๊ฐ ๋ฌด์์ธ์ง ๋ ์ ์ดํดํ๊ธฐ ์ํด ๊ณผํ์๋ HBV์ ๋ค์ํ ํญ์/๋จ๋ฐฑ์ง์ ๋ณ๋์ ํ๋ผ์ค๋ฏธ๋์ ์ํธํํ๊ณ ๊ฐ์ธํฌ๋ฅผ HDV์ ํจ๊ป ๊ฐ์ผ์์ผฐ์ต๋๋ค. ์ด๋ค ์คํ์์ ์ ์ ํ HBV ํญ์/๋จ๋ฐฑ์ง๊ณผ ํจ๊ป ์์กด ๊ฐ๋ฅํ HDV ๋ฐ์ด๋ฌ์ค ์
์๊ฐ ์์ฑ๋๊ฒ ์ต๋๊น? | HBsAg | {
"A": "HBsAg",
"B": "HBcAg",
"C": "HBV RNA polymerase",
"D": "HBeAg"
} | step1 | A | [
"previous experiment infecting hepatocytes",
"shown",
"viable HDV virions",
"only",
"presence of",
"co infection",
"better understand",
"particle",
"production",
"viable HDV virions",
"scientist encoded",
"separate plasmids",
"various antigens/proteins",
"co infected",
"hepatocytes",
"HDV",
"experiments",
"viable HDV virions",
"conjunction",
"appropriate",
"antigen/protein"
] | 00000000000000000249 |
61์ธ ์ฌ์ฑ์ด ์ ๊ธฐ ๊ฒ์ง์ ์ํด ์ฃผ์น์์๊ฒ ๋ด์ํ์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ, ๊ทธ๋
์ ๋ฐ์์ ๋น๋์นญ์ ์ธ ๋ง์ด ์ ๊ฒฝ๋ณ์ฆ์ด ๋ํ๋ฌ์ต๋๋ค. ํ์๋ ์ด์ ์ ๊ด๋ จ ๋ณ๋ ฅ์ด ์์ผ๋ฉฐ ๋น๋จ๋ณ ์ฆ์๋ ๋ถ์ธํ์ต๋๋ค. ์ผ๋ฐ ํ์ก ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ์ ์์ผ๋ก ๋ํ๋ฌ๊ณ , ๊ทธ๋
๋ ํ์กํ ์ ๋ฌธ์์๊ฒ ์๋ขฐ๋์์ต๋๋ค. ์ดํ ํ์ฒญ ๋จ๋ฐฑ ์ ๊ธฐ ์๋ ๊ฒ์ฌ ๊ฒฐ๊ณผ, ๊ฐ๋ง ๊ธ๋ก๋ถ๋ฆฐ ์์น๊ฐ ์ฝ๊ฐ ์์นํ ๊ฒ์ผ๋ก ๋ํ๋ฌ์ผ๋ฉฐ, monoclonal gammopathy of undetermined significance๊ฐ ์ง๋จ๋์์ต๋๋ค. ๋ค์ ์ค ์ด ํ์์ ์ํ์์ ๊ฐ์ฅ ๋ฐ์ ํ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ง๋ณ์ ๋ฌด์์
๋๊น? | Multiple myeloma | {
"A": "Waldenstrรถm macroglobulinemia",
"B": "Multiple myeloma",
"C": "Acute myelocytic leukemia",
"D": "Chronic myelocytic leukemia"
} | step1 | B | [
"61 year old woman presents",
"primary care physician",
"routine check-up",
"Physical examination demonstrates asymmetric peripheral neuropathy",
"feet",
"patient",
"previous relevant history",
"denies",
"symptoms",
"diabetes",
"Routine blood work shows normal results",
"referred to",
"hematologist",
"Subsequent serum protein electrophoresis demonstrates",
"slightly elevated gamma globulin level",
"monoclonal gammopathy of undetermined significance",
"diagnosed",
"following diseases",
"most likely to",
"course",
"patients condition"
] | 00000000000000000250 |
71์ธ ๋จ์ฑ์ด ์์ ๋จ๋ฆผ์ผ๋ก ์ธํด ์ ์ ๋ ๊ณ ํต์ค๋ฌ์ ์ฃผ์น์์๊ฒ ๋ด์ํ์ต๋๋ค. ๊ทธ๋ ๋จ๋ฆผ์ด ํด์์ ์ทจํ ๋ ๋ ์ฌํด์ง๊ณ ๋ฌผ๊ฑด์ ์ก์ผ๋ ค๊ณ ํ ๋ ํธ์ ๋๋ค๊ณ ๋งํฉ๋๋ค. ๊ทธ์ ์๋ด๋ ๊ทธ๊ฐ ์์ง์์ด ๋๋ ค์ง๊ณ ๊ฑท๊ธฐ ์์ํ๋ ๋ฐ ์ด๋ ค์์ ๊ฒช๊ณ ์๋ค๊ณ ๋ณด๊ณ ํฉ๋๋ค. ๊ทธ์ ๊ฑธ์๊ฑธ์ด๋ ์์ง์์ ์์ํ ์ ์์ ๋์๋ ์งง๊ณ ๋ถ์์ ํ์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ๋ฅ๋์ ์ด๋ ๋ฒ์ ๊ฒ์ฌ ์ ๊ทผ์ก ๊ฐ์ง์ด ๋ํ๋ฌ์ต๋๋ค. ์ด ํ์์ ์กฐ์งํ์ ๊ฒ์ฌ์์ ๋ค์ ์ค ์ด๋ค ์๊ฒฌ์ด ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ต๋๊น? | Alpha-synuclein | {
"A": "Alpha-synuclein",
"B": "Intracellular hyperphosphorylated tau",
"C": "Hyperphosphorylated tau inclusion bodies",
"D": "Perivascular inflammation"
} | step1 | A | [
"71 year old man presents",
"primary care physician",
"tremor",
"hands",
"tremor",
"worse",
"resting",
"gets better",
"reaches",
"objects",
"wife reports",
"slowing",
"movements",
"difficulty starting to walk",
"steps",
"short",
"unsteady",
"able to initiate movement",
"Physical exam reveals rigidity",
"muscles",
"tested",
"active range of motion",
"Histology",
"patient",
"most likely reveal",
"following findings"
] | 00000000000000000251 |
52์ธ ๋จ์ฑ์ด ํด๊ฐ ์ค์ ๊ฐ์์ค๋ฌ์ด ํ๊ธฐ์ฆ๊ณผ ๋ณดํ ์ฅ์ ๋ก ์๊ธ์ค์ ์ค๋ ค ์์ต๋๋ค. ๊ทธ๋ ์ผ์ฃผ์ผ ์ ํด๊ฐ๋ฅผ ์์ํ ์ดํ ์ ์์ ์ธ ๊ฑด๊ฐ ์ํ์์ผ๋, ์ค๋ ๊ท ํ ์์ค, ๊ฒฝ๋ฏธํ ๋ํต์ ๊ฒช๊ณ ์์ผ๋ฉฐ ์ง๋ ๋ช ์๊ฐ ๋์ 5-6ํ ๊ตฌํ ๋ฅผ ํ์ต๋๋ค. ๊ทธ๋ ๋ฐ์ด, ๋ชฉ ํต์ฆ, ๋จธ๋ฆฌ ์ธ์, ์ ์ฝ ๋ฐ ๋ณต์๋ฅผ ๋ถ์ธํฉ๋๋ค. ๊ณผ๊ฑฐ ๋ณ๋ ฅ์ ๊ณ ํ์๊ณผ ์ด์์ง์งํ์ฆ์ด ์์ต๋๋ค. ๊ทธ์ ์ฝ๋ฌผ์๋ valsartan๊ณผ atorvastatin์ด ํฌํจ๋์ง๋ง ์ด๋ฒ ์ฌํ์ ๋ ๋ ์ดํ ์ฌ๋ฌ ๋ฒ ๋ณต์ฉ์ ๋์ณค์ต๋๋ค. ํ์์ 198/112 mm Hg, ์ฌ๋ฐ์๋ 76/min, ํธํก์๋ 16/min, ์ฒด์จ์ 37.0ยฐC (98.6ยฐF)์
๋๋ค. ํ์๋ ์์์ด ์๊ณ ์๊ฐ, ์ฅ์, ์ฌ๋์ ๋ํด ์ง๋จ๋ ฅ์ด ์์ต๋๋ค. Extraocular movements๋ ์ ์ ๋ฒ์ ๋ด์ ์์ต๋๋ค. Muscle strength๋ 4๊ฐ์ ์ฌ์ง ๋ชจ๋์์ ์ ์์
๋๋ค. ์๊ธ ๋๋ถ CT๊ฐ ์ฃผ๋ฌธ๋์๊ณ ์ฌ์ง์ ๋์ ์์ต๋๋ค. ์ด ํ์์๊ฒ์ ์ด๋ค ์ถ๊ฐ์ ์ธ ์์์ ํน์ง์ด ์์๋ฉ๋๊น? | Inability to perform repetitive alternating movements | {
"A": "Inability to comprehend commands",
"B": "Inability to perform repetitive alternating movements",
"C": "Right-sided neglect",
"D": "Right-sided visual field loss"
} | step2&3 | B | [
"year old man",
"brought",
"emergency department",
"vacation",
"history of sudden onset vertigo",
"difficulty walking",
"normal health",
"starting",
"vacation",
"week",
"today",
"suffering",
"loss of balance",
"mild headache",
"episodes of vomiting",
"last",
"hours",
"denies fever",
"neck pain",
"head trauma",
"weakness",
"diplopia",
"Past medical history",
"significant",
"hypertension",
"dyslipidemia",
"medications include valsartan",
"atorvastatin",
"missed several doses",
"leaving",
"trip",
"Blood pressure",
"mm Hg",
"heart rate",
"76 min",
"respiratory rate",
"min",
"temperature",
"98",
"patient",
"awake",
"oriented to time",
"place",
"person",
"Extraocular movements",
"normal limits",
"Muscle strength",
"normal",
"extremities",
"urgent head CT",
"ordered",
"shown",
"picture",
"additional clinical features",
"expected",
"patient"
] | 00000000000000000252 |
๊ณผ๊ฑฐ ์ผ์ฃผ์ผ ๋์ ๋ชฉ์ ํต์ฆ ์๋ ๋ถ์ข
์ ํธ์ํ๋ 65์ธ ๋จ์ฑ์ด ๋ด์ํ์ต๋๋ค. ๊ทธ๋ ๋ํ ๋ค์ ๋ ์ท๊ณผ ์นจ๊ตฌ๋ฅ๋ฅผ ๊ฐ์์
์ด์ผ ํ ์ ๋๋ก ์ฌํ ์ผ๊ฐ ๋ฐํ์ ๊ฒฝํํ๋ค๊ณ ์ธ๊ธํ์ต๋๋ค. ๊ทธ์ ๋ณ๋ ฅ์ ์ค๋ซ๋์ ์ง์๋ ๊ณ ํ์์ผ๋ก ํน๊ธฐํ ๋งํฉ๋๋ค. ๊ทธ๋ 6๋
์ ์ ์ ์ฅ ์ด์์ ๋ฐ์์ต๋๋ค. ํ์ฌ ๋ณต์ฉ ์ค์ธ ์ฝ๋ฌผ์ amlodipine, metoprolol, furosemide, aspirin, tacrolimus ๋ฐ mycophenolate์
๋๋ค. ๊ทธ์ ๊ฐ์กฑ๋ ฅ์ ์๋
์ ๋ฆผํ์ข
์ผ๋ก ์ฌ๋งํ ๋๋๊ฐ ์๋ค๋ ์ ์ด ํน๊ธฐํ ๋งํฉ๋๋ค. ์ ์ ๊ฒํ ์์ ์ง๋ 2๊ฐ์ ๋์ 6kg (13.2lb)์ ์๋ํ์ง ์์ ์ฒด์ค ๊ฐ์๊ฐ ํ์ธ๋์์ต๋๋ค. ๊ทธ์ ํ๋ ฅ ์งํ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค: ์ฒด์จ 37.8โ (100.0โ) ๋ฐ ํ์ 120/75 mm Hg. ์ ์ฒด ๊ฒ์ฌ์์, ์์ธก ๋ชฉ์ ์์ชฝ ๋ฐ ๋ค์ชฝ ์ผ๊ฐ ๋ถ์์์ ํ๊ท ์ง๊ฒฝ 2cm์ ์ฌ๋ฌ ๊ฐ์ ํต์ฆ ์๋ ๋ฆผํ์ ์ด ์ด์ง๋ฉ๋๋ค. ๊ฒจ๋๋์ด ๋ฐ ์ฌํ๊ตฌ๋ ๋ฆผํ์ ๋ณ์ฆ์ด ์ค๋ฅธ์ชฝ์์ ์ด์ง๋ฉ๋๋ค. ๋ณต๋ถ ๊ฒ์ฌ์์ ํ์ง ์ ๋๊ณจ ํ๋จ์์ 16cm ๋จ์ด์ง ๋น์ฅ์ด ํ์ธ๋์์ต๋๋ค. ๊ฒ์ฌ์ค ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค:
Hemoglobin 9 g/dL
Mean corpuscular volume 88 ฮผm3
Leukocyte count 12,000/mm3
Platelet count 130,000/mm3
Creatinine 1.1 mg/dL
Lactate dehydrogenase (LDH) 1 000 U/L
๋ง์ด ํ์ก ๋๋ง ๊ฒ์ฌ๋ ํน์ด ์ฌํญ์ด ์์ต๋๋ค. ์ด ํ์์๊ฒ ๊ฐ์ฅ ์ ๋ ฅํ ์ง๋จ์ ๋ฌด์์
๋๊น? | Non-Hodgkinโs lymphoma (NHL) | {
"A": "์ฝ๋ฌผ ์ ๋ฐ ๋ฆผํ์ ๋ณ์ฆ",
"B": "๊ฑฐ๋์ธํฌ๋ฐ์ด๋ฌ์ค ๊ฐ์ผ",
"C": "๋ค๋ฐ์ฑ ๊ณจ์์ข
",
"D": "๋นํธ์งํจ ๋ฆผํ์ข
(NHL)"
} | step2&3 | D | [
"65 year old man presents",
"painless swelling of the neck",
"past week",
"noted severe night sweats",
"change",
"clothes",
"bed linens",
"next day",
"medical history",
"significant",
"long standing hypertension",
"received",
"kidney transplant",
"years",
"current medications include amlodipine",
"metoprolol",
"furosemide",
"aspirin",
"tacrolimus",
"mycophenolate",
"family history",
"significant",
"sister",
"died last year",
"lymphoma",
"review of systems",
"positive",
"kg",
"unintentional weight loss",
"past",
"months",
"vital signs include",
"temperature",
"100 0",
"blood pressure",
"75 mm Hg",
"physical examination",
"multiple painless lymph nodes",
"averaging 2",
"diameter",
"palpable",
"anterior",
"posterior triangles of",
"neck",
"Axillary",
"inguinal lymphadenopathy",
"palpated",
"right side",
"Abdominal examination",
"significant",
"spleen",
"cost margin",
"percussion",
"Laboratory studies",
"significant",
"following",
"Hemoglobin",
"g dL Mean corpuscular volume",
"Leukocyte 12",
"mm3 Platelet count",
"Creatinine 1",
"mg dL Lactate dehydrogenase",
"U L",
"peripheral blood smear",
"unremarkable",
"following",
"most likely diagnosis",
"patient"
] | 00000000000000000253 |
56์ธ ๋จ์ฑ์ด ์์ด ์๋ ์ค ๋ฏธ์ง์ ๋ฌผ์ง์ ์ญ์ทจํ ํ 2์๊ฐ ๋ง์ ์ด์์ ์ํด ์๊ธ์ค๋ก ์ด์ก๋์์ต๋๋ค. ๊ทธ๋ ํผ๋์ค๋ฌ์ํ๋ฉฐ ๋ ์์ธํ ๋ณ๋ ฅ์ ์ ๊ณตํ ์ ์์ต๋๋ค. ๊ทธ์ ์ฒด์จ์ 39.1ยฐC (102.3ยฐF), ๋งฅ๋ฐ์ 124ํ/๋ถ, ํธํก์๋ 12ํ/๋ถ, ํ์์ 150/92 mm Hg์
๋๋ค. ๊ทธ์ ํผ๋ถ๋ ๊ฑด์กฐํฉ๋๋ค. ๋๊ณต์ 12 mm์ด๊ณ ์ต์ํ์ผ๋ก ๋ฐ์ํฉ๋๋ค. ECG์์๋ ์ด์์ด ๋ฐ๊ฒฌ๋์ง ์์์ต๋๋ค. ๋ค์ ์ค ์ด ํ์์ ์ํ์ ๊ฐ์ฅ ์ ์ ํ ์น๋ฃ๋ฒ์ ๋ฌด์์
๋๊น? | Physostigmine | {
"A": "Sodium bicarbonate",
"B": "Physostigmine",
"C": "Glucagon",
"D": "Flumazenil"
} | step1 | B | [
"year old man",
"brought",
"emergency department",
"neighbor",
"hours",
"ingesting",
"unknown substance",
"suicide attempt",
"confused",
"unable to provide further history",
"temperature",
"pulse",
"min",
"respiratory rate",
"min",
"blood pressure",
"mm Hg",
"skin",
"dry",
"Pupils",
"mm",
"reactive",
"ECG shows",
"abnormalities",
"following",
"most appropriate treatment",
"patient's condition"
] | 00000000000000000254 |
81์ธ ๋จ์ฑ์ด ์ฐ๋ก ๊ฒ์ง์ ์ํด ์ฃผ์น์์๊ฒ ๋ด์ํ์ต๋๋ค. ๊ทธ์ ๊ณผ๊ฑฐ ๋ณ๋ ฅ์ ๊ณจ๊ฐ์์ฆ, ์ ์ฅ ๊ฒฐ์์ฆ, ๊ทธ๋ฆฌ๊ณ ๊ณ ํ์์ผ๋ก ํน๊ธฐํ ๋งํฉ๋๋ค. ๊ทธ์ ๊ฐ์กฑ๋ ฅ์ ์กฐ๊ธฐ์ ์ ๋ถ์ ์ ๊ฒช์ ์น์ฒ๋ค์ด ์์๋ค๋ ์ ์ด ํน์ง์
๋๋ค. ๊ทธ๋ ๊ฐ๋ ์์ธํธ์๋ฏธ๋
ธํ๊ณผ ์นผ์/๋นํ๋ฏผ D ๋ณด์ถฉ์ ๋ฅผ ๋ณต์ฉํฉ๋๋ค. ๊ทธ๋ ์ ์ ์ฒด์ง๋ ์ง์(BMI)๋ฅผ ์ ์งํ๋ฉฐ ์ ์ฒด์ ์ผ๋ก ํ๋์ ์ด๋ฉฐ ํ์ฌ ํน๋ณํ ์ฐ๋ ค ์ฌํญ์ ์์ต๋๋ค. ์ค๋ ๊ทธ์ ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ 15๋
์ ๊ฒฐ๊ณผ์ ๋น๊ต๋์์ผ๋ฉฐ ๋ค์๊ณผ ๊ฐ์ ์๊ฒฌ์ ๋ณด์์ต๋๋ค.
์ค๋ ๊ฒฐ๊ณผ:
ํ์ฒญ ํฌ๋ ์ํฐ๋ ๋๋: 1.1 mg/dL
์๋ณ ํฌ๋ ์ํฐ๋ ๋๋: 100 mg/dL
์๋ณ๋: 1000 mL/day
15๋
์ ๊ฒฐ๊ณผ:
ํ์ฒญ ํฌ๋ ์ํฐ๋ ๋๋: 1.1 mg/dL
์๋ณ ํฌ๋ ์ํฐ๋ ๋๋: 120 mg/dL
์๋ณ๋: 1000 mL/day
์ด๋ฌํ ํฌ๋ ์ํฐ๋ ์ฒญ์์จ ๋ณํ์ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ ์๋ ์์ธ์ ๋ฌด์์
๋๊น? | Normal aging | {
"A": "์์ฑ ์ ๋ฆฝ์ ๋น๋์ฆ",
"B": "์ ์ฅ ๊ฒฐ์์ฆ",
"C": "์ ์์ ์ธ ๋
ธํ",
"D": "์ ํ๊ด ์งํ"
} | step1 | C | [
"81 year old man presents",
"primary care physician",
"yearly exam",
"past medical history",
"significant",
"osteopenia",
"nephrolithiasis",
"hypertension",
"family history",
"significant",
"relatives",
"early onset kidney failure",
"takes occasional acetaminophen",
"supplemental calcium/vitamin D",
"active",
"normal body mass index",
"current concerns",
"Review",
"laboratory results today",
"compared",
"years",
"following findings",
"Results today",
"Serum concentration",
"1.1 mg/dL Urine creatinine concentration",
"100 mg/dL Urine volume",
"mL/day",
"Results",
"years",
"Serum concentration",
"1.1 mg/dL Urine creatinine concentration",
"mg/dL Urine volume",
"mL/day",
"most likely cause",
"changes",
"creatinine clearance"
] | 00000000000000000255 |
72์ธ ๋จ์ฑ์ด 1์ฃผ์ผ ์ ๋์ ํผ๋ก, ๊ฒฝ๋ฏธํ ๋ํต, ๊ทธ๋ฆฌ๊ณ ์น์ ๋์ ๋ถํธํจ์ ์ฃผ์๋ก ์ผ์ฐจ ์ง๋ฃ ์์ฌ๋ฅผ ๋ฐฉ๋ฌธํ์ต๋๋ค. ์ด ์ ์๋ ์ ๋ฐ์ ์ผ๋ก ๊ฑด๊ฐํ์ง๋ง, ํ์ฌ๋ ์ด๋ฌํ ์ฆ์๋ค๋ก ๋งค์ฐ ๋ถํธํจ์ ๋๋ผ๊ณ ์์ต๋๋ค. ๊ทธ์ ๋ณ๋ ฅ์ ๊ณ ํ์๊ณผ ๊ณ ์งํ์ฆ์ผ๋ก, ๋ ๋ค ์กฐ์ ๋๊ณ ์์ต๋๋ค. ์ง์ฐฐ ๊ฒฐ๊ณผ, ๊ทธ๋ ๋ถํธํด ๋ณด์ด์ง๋ง ๋
์ฑ์ ์์ด ๋ณด์
๋๋ค. ์ค๋ฅธ์ชฝ ์ธก๋ ๋๋งฅ ์ด์ง ์ ๊ฒฝ๋ฏธํ ์ํต์ด ์์์ง๋ง, ๊ทธ ์ธ์๋ ํน๋ณํ ์๊ฒฌ์ด ์์์ต๋๋ค. ์ ์ํ ์ธ์ง์ ์น๋ฃ๋ ๋ค์์ ๋๋ ค์ด ํฉ๋ณ์ฆ ์ค ๋ฌด์์ ์๋ฐฉํ ์ ์์๊น์? | Blindness | {
"A": "์ ๋ถ์ ",
"B": "์ค๋ช
",
"C": "ํ ์ฌ์ ์ฆ",
"D": "์ธ์ง ์ฅ์ "
} | step2&3 | B | [
"72 year old man presents",
"primary care provider",
"fatigue",
"mild headache",
"discomfort",
"chewing",
"week",
"felt well overall",
"now",
"symptoms",
"medical history",
"notable",
"hypertension",
"hyperlipidemia",
"controlled",
"examination",
"nontoxic appearing",
"mild tenderness",
"palpation",
"right temporal artery",
"exam",
"not revealing",
"Prompt recognition",
"treatment",
"prevent",
"following feared complications"
] | 00000000000000000256 |
14๊ฐ์ ๋ ๋จ์์์ด๊ฐ ๋ฐ์ง ํ๊ฐ๋ฅผ ์ํด ์ง๋ฃ์ค๋ก ๋ด์ํ์ต๋๋ค. ๋ฐ์ง์ ์ผ๊ตด์์ ์์ํ์ฌ ๋ชธํต์ผ๋ก ํผ์ก์ต๋๋ค. ๊ทธ๋ ๋ํ ์ง๋ 2์ผ ๋์ ์ด๊ณผ ๊ธฐ์นจ์ ๋ณด์์ต๋๋ค. ๊ทธ์ ์ด๋จธ๋๋ ๊ทธ๋ค์ด ์ต๊ทผ ์์์์์ ์ด๋ฏผ ์์ผ๋ฉฐ ์๋ฐฉ ์ ์ข
๊ธฐ๋ก์ ์ ๊ณตํ ์ ์๋ค๊ณ ๋งํฉ๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ๋ฆผํ์ ๋ณ์ฆ์ ์์ผ๋ฉฐ ์ผ๊ตด, ๋ชธํต ๋ฐ ๊ทผ์ ์ฌ์ง์ ๋ฐ์ ๊ตฌ์ง ๋ฐ์ง์ด ๋ํ๋ฌ์ต๋๋ค. ๊ตฌ๊ฐ ์ ๋ง์์ ์ฒญ๋ฐฑ์ ๋ฐ์ ์ด ๊ด์ฐฐ๋์๊ณ ์์ชฝ ๋์ ๊ฒฝ๋ฏธํ ๊ฒฐ๋ง ์ถฉํ์ด ์์์ต๋๋ค. ์ด ์งํ์ ์์ธ์ฒด๋ ๋ค์ ๋ฐ์ด๋ฌ์ค ๊ณผ ์ค ์ด๋ ๊ฒ์ ์ํฉ๋๊น? | ssRNA enveloped viruses | {
"A": "ssDNA enveloped viruses",
"B": "ssRNA naked viruses",
"C": "dsRNA naked viruses",
"D": "ssRNA enveloped viruses"
} | step1 | D | [
"month old boy",
"brought",
"clinic",
"evaluation",
"rash",
"rash started",
"face",
"spread",
"trunk",
"fever",
"cough",
"past 2 days",
"mother",
"recently",
"Asia",
"provide vaccination records",
"physical examination reveals",
"maculopapular rash on",
"face",
"trunk",
"proximal limbs",
"lymphadenopathy",
"Blue white spots",
"noted",
"oral mucosa",
"bilateral mild conjunctival injection",
"causative agent",
"condition",
"following virus families"
] | 00000000000000000257 |
31์ธ์ G1P0 ์ฌ์ฑ ํ์๊ฐ ์์ 26์ฃผ์ฐจ์ ์ด์ ํ๋น ๋ด์ฑ ๊ฒ์ฌ ํ๊ฐ๋ฅผ ์ํด ๋ณ์์ ๋ด์ํ์ต๋๋ค. ํ์๋ ์ฆ์์ ๋ถ์ธํ์ง๋ง, 1์ฃผ์ผ ์ ์ 50 g์ ๊ฒฝ๊ตฌ ํฌ๋๋น์ ํฌ์ฌ๋ฐ์๊ณ ์ดํ 1์๊ฐ ๋ค ์ ๋งฅ ํ์ฅ glucose ์์น๊ฐ 156 mg/dL๋ก ๋ํ๋ฌ๋ค๊ณ ์ง์ ํ์ต๋๋ค. ํ๋ ฅ ์งํ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค: ํ์, 112/78 mm Hg; ๋งฅ๋ฐ, 81/min; ํธํก์, 16/min. ์ ์ฒด ๊ฒ์ฌ๋ ์ ์ ๋ฒ์ ๋ด์ ์์ต๋๋ค. ๋ค์ ์ค ๊ด๋ฆฌ์์ ๊ฐ์ฅ ์ ์ ํ ๋ค์ ๋จ๊ณ๋ ๋ฌด์์
๋๊น? | Administer an oral, 3-hour 100 g glucose dose | {
"A": "Repeat the 50 g oral glucose challenge",
"B": "Administer an oral, 3-hour 100 g glucose dose",
"C": "Advise the patient to follow an American Diabetic Association diet plan",
"D": "Begin insulin treatment"
} | step2&3 | B | [
"31 year old",
"woman",
"weeks presents",
"clinic",
"evaluation",
"abnormal glucose tolerance test",
"denies",
"symptoms",
"states",
"given 50 g",
"oral 1 earlier",
"subsequent venous level",
"mg/dL 1 hour later",
"vital signs",
"blood pressure",
"mm Hg",
"pulse",
"81 min",
"respiratory rate",
"min",
"Physical examination",
"normal limits",
"following",
"most appropriate next step",
"management"
] | 00000000000000000258 |
์ฐ์ ๊ด๋ฆฌ๊ฐ ๋ถ์คํ ์ฐ๋ชจ์ ์ ์์์๊ฒ์ ์ ์๋ณด๋ค ํฐ ๋จธ๋ฆฌ ๋๋ ์ ํฝ์ฐฝ๋ ํฐํ๋ฌ์ด ๋ฐ๊ฒฌ๋์์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ, ๋๊บผํ ํํด์ ์๋ ด-ํํด ์์ง์ด ํ์ ํ ์ํ์์ ์๋๋ฅผ ํฅํ ์์ ์ด ์ฐ์ธํ๊ฒ ๋ํ๋ฌ์ต๋๋ค. ์ด์ํ ๊ฒ์ฌ์์ ํฝ์ฐฝ๋ ์ธก๋์ค๊ณผ ํฝ์ฐฝ๋ ์ 3๋์ค์ด ๊ด์ฐฐ๋์์ต๋๋ค. ์ถ๊ฐ์ ์ธ ์์ ๊ฒ์ฌ ๊ฒฐ๊ณผ ์ก๊ณผ์ฒด ๋ถ์์ ๊ณ ํ ๋ฉ์ด๋ฆฌ๊ฐ ๋ํ๋ฌ์ต๋๋ค. ๋ค์ ์ค ์ด ํ์์๊ฒ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์๊ฒฌ์ ๋ฌด์์
๋๊น? | Compression of periaqueductal grey matter | {
"A": "์ ์ ์์ถ ์ฒ์ ๊ฐ๊ตฌ ์๋ ฅ",
"B": "ํฝ์ฐฝ๋ ๋์กฐ",
"C": "๋์ค ์๋๊ด ์ฃผ์ ํ๋ฐฑ์ง ์๋ฐ",
"D": "๋น๋๋ ๊ฑฐ๋ฏธ๋ง ๊ณผ๋ฆฝ"
} | step1 | C | [
"newborn",
"mother",
"poor antenatal care",
"found to",
"larger",
"normal head circumference",
"bulging fontanelles",
"Physical examination reveals",
"predominant downward gaze",
"marked eyelid retraction",
"convergence-retraction nystagmus",
"Ultrasound examination showed dilated lateral ventricles",
"dilated third ventricle",
"Further imaging studies reveal",
"solid mass",
"pineal region",
"following",
"most likely finding",
"patient"
] | 00000000000000000259 |
22์ธ ๋จ์ฑ์ด ์ง๋ 2์ผ ๋์ ๋ฐ์ํ ์ฐ์ธก ์ฝ์ง์ ์งํ์ฑ ๋ถ์ข
๊ณผ ํต์ฆ์ผ๋ก ์์ฌ๋ฅผ ์ฐพ์์์ต๋๋ค. ํต์ฆ์ ์ถ๊ตฌ๋ฅผ ํ๋ ์ค ๋ค๋ฅธ ์ ์์ ์ ๋ํผ์ ์๊ฐ๋ฝ์ด ๊ฑธ๋ ค ๊ฐ์ ๋ก ์ก์๋น๊ฒจ์ง๋ฉด์ ์์๋์์ต๋๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ ์ฐ์ธก ์ฝ์ง๊ฐ ์ ์ ๋์ด ์์ต๋๋ค. ์์ ์ง๊ณจ๊ฐ ๊ด์ ์ ํต์ฆ๊ณผ ๋ถ์ข
์ด ์์ต๋๋ค. ํ์์๊ฒ ์ฃผ๋จน์ ์ฅ์ด๋ณด๋ผ๊ณ ํ์ ๋, ๊ทธ์ ์ฐ์ธก ์ฝ์ง๋ ์์ ์ง๊ณจ๊ฐ ๊ด์ ์์ ๊ตด๊ณก๋์ง ์์ต๋๋ค. ๊ด์ ์ด์์ ์์ต๋๋ค. ๋ค์ ์ค ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ง๋จ์ ๋ฌด์์
๋๊น? | Rupture of the flexor digitorum profundus tendon at its point of insertion | {
"A": "Rupture of the flexor digitorum profundus tendon at its point of insertion",
"B": "Closed fracture of the distal phalanx",
"C": "Inflammation of the flexor digitorum profundus tendon sheath",
"D": "Slipping of the central band of the extensor digitorum tendon"
} | step1 | A | [
"year old man",
"physician",
"progressive swelling",
"pain",
"right ring finger",
"past 2 days",
"pain began",
"playing football",
"finger",
"caught",
"jersey",
"pulled",
"Examination shows",
"right ring finger",
"extended",
"pain",
"swelling",
"distal",
"patient",
"to make",
"fist",
"right ring finger",
"not",
"distal interphalangeal joint",
"joint laxity",
"following",
"most likely diagnosis"
] | 00000000000000000260 |
50์ธ ๋จ์ฑ์ด ์ ๊ธฐ ๊ฒ์ง์ ์ํด ์์ฌ๋ฅผ ์ฐพ์์์ต๋๋ค. ๊ทธ๋ 2๊ฐ์ ๋์ ๋ชฉ๋๋ฏธ์ ์ ์ง์ ์ผ๋ก ์ฆ๊ฐํ๋ ๋ถ์ข
์ด ์์์ต๋๋ค. ๊ทธ๋ ๋ฐ์ด์ด๋ ๋ถ์ข
์ผ๋ก๋ถํฐ์ ์ด๋ ํ ๋ถ๋น๋ฌผ๋ ์์ต๋๋ค. ๊ทธ๋ 43์ธ์ ๊ฒฐ์ฅ์์ผ๋ก colectomy๋ฅผ ๋ฐ์์ต๋๋ค. ๊ทธ๋ ์ 2ํ diabetes mellitus, hypertension, ๊ทธ๋ฆฌ๊ณ ์ผ์ชฝ ๋ฌด๋ฆ์ osteoarthritis๋ฅผ ์๊ณ ์์ต๋๋ค. ํ์ฌ ๋ณต์ฉ ์ค์ธ ์ฝ๋ฌผ์๋ insulin glargine, metformin, enalapril, ๊ทธ๋ฆฌ๊ณ naproxen์ด ์์ต๋๋ค. ๊ทธ๋ ์ง๋ 6๋
๋์ ๊ตํต ๊ฐ์์์ผ๋ก ์ผํ์ผ๋ฉฐ ์์ฃผ ๊ณจํ๋ฅผ ์นฉ๋๋ค. ๊ทธ๋ ๊ฑด๊ฐํด ๋ณด์
๋๋ค. ๊ทธ์ ์ฒด์จ์ 37.3ยฐC (99.1ยฐF), ๋งฅ๋ฐ์ 88/min, ๊ทธ๋ฆฌ๊ณ ํ์์ 130/86 mm Hg์
๋๋ค. ๋ชฉ ๊ฒ์ฌ ๊ฒฐ๊ณผ 2.5cm (1-in) ํฌ๊ธฐ์ ๋จ๋จํ๊ณ ์์ง์์ด ์์ผ๋ฉฐ ํต์ฆ์ด ์๋ ๊ฒฐ์ ์ด ๋ํ๋ฉ๋๋ค. ๊ฒฐ์ ์์ ํผ๋ถ๋ ๊ผฌ์ง์ ์ ์์ต๋๋ค. ํ๋ ์ฒญ์ง์ ๊นจ๋ํฉ๋๋ค. ๋๋จธ์ง ๊ฒ์ฌ์์๋ ์ด์์ด ์์ต๋๋ค. ๋ณ๋ณ ์ฌ์ง์ด ์ ์๋ฉ๋๋ค. ๋ค์ ์ค ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ง๋จ์ ๋ฌด์์
๋๊น? | Epidermoid cyst | {
"A": "Actinic keratosis",
"B": "Epidermoid cyst",
"C": "Dermatofibroma",
"D": "Squamous cell carcinoma"
} | step2&3 | B | [
"50 year old man",
"physician",
"routine checkup",
"increasing swelling",
"the nape of",
"neck",
"2 months",
"not",
"fever",
"discharge",
"swelling",
"colectomy",
"colon cancer",
"age",
"years",
"type 2 diabetes mellitus",
"hypertension",
"osteoarthritis of",
"left knee",
"Current medications include insulin glargine",
"metformin",
"enalapril",
"naproxen",
"worked",
"traffic warden",
"past",
"years",
"frequently plays golf",
"appears healthy",
"temperature",
"3C",
"99",
"pulse",
"88 min",
"blood pressure",
"mm Hg",
"Examination of",
"neck shows",
"2.5",
"1",
"firm",
"mobile",
"painless nodule",
"skin",
"nodule",
"pinched",
"lungs",
"clear",
"auscultation",
"examination shows",
"abnormalities",
"photograph",
"lesion",
"shown",
"following",
"most likely diagnosis"
] | 00000000000000000261 |
67์ธ ๋จ์ฑ์ด 3์ผ๊ฐ์ ๋ฐ์ด, ์คํ, ๋ํต ๋ฐ ํผ๋ก๊ฐ์ผ๋ก ์ธํด ์์ฌ๋ฅผ ์ฐพ์์์ต๋๋ค. ๊ทธ๋ ์ํ ๋ณด์
๋๋ค. ๊ทธ์ ์ฒด์จ์ 39ยฐC (102.2ยฐF)์
๋๋ค. ๋น๊ฐ ๋ถ๋น๋ฌผ ๋ถ์ ๊ฒฐ๊ณผ, ์ธํผ๋ฅผ ๊ฐ์ง ๋จ์ผ ๊ฐ๋ฅ ๋ถ์ RNA ๋ฐ์ด๋ฌ์ค์ ๊ฐ์ผ๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ์ต๋๋ค. ์ด ๋ณ์์ฒด ๊ฐ์ผ์ ๋ํ ๋ฐ์์ผ๋ก ํน์ ์ธํฌ๋ ๋ณ์์ฒด์ ํญ์์ CD8+ T-lymphocytes์ ์ ์ํฉ๋๋ค. ์ด๋ฌํ ํญ์ ์ ์์ ์ฌ์ฉ๋๋ ๋ถ์์ ๋ํ ๋ค์ ์ค๋ช
์ค ๊ฐ์ฅ ์ ํํ ๊ฒ์ ๋ฌด์์
๋๊น? | The molecule consists of a heavy chain associated with ฮฒ2 microglobulin | {
"A": "The antigens are loaded onto the molecule within lysosomes",
"B": "The molecule consists of a heavy chain associated with ฮฒ2 microglobulin",
"C": "The molecule is made up of 2 chains of equal length",
"D": "The molecule is selectively expressed by antigen-presenting cells"
} | step1 | B | [
"67 year old man",
"physician",
"3-day history",
"fever",
"chills",
"headache",
"fatigue",
"appears ill",
"temperature",
"Analysis",
"nasal secretions shows infection",
"single-stranded segmented RNA virus",
"response",
"infection",
"pathogen",
"certain cells present antigens",
"pathogen",
"CD8",
"T-lymphocytes",
"following statements",
"molecules used",
"presentation",
"antigens",
"most accurate"
] | 00000000000000000262 |
58์ธ ์ฌ์ฑ ํ์๊ฐ ๋ ๋ณดํ๋ก์ฌ์ ์ผ๋ก ์ง์ญ์ฌํ ํ๋ ํ๋ ด ์น๋ฃ๋ฅผ ๋ฐ๋ ์ค ๋ฌผ ์ค์ฌ๋ฅผ ๊ฒช์ต๋๋ค. ํ์๋ ์ง๋ ์ดํ ๋์ ์ต์ 9๋ฒ์ ์ค์ฌ ์ํผ์๋๋ฅผ ๋ณด๊ณ ํ์ผ๋ฉฐ, ํ๋ณต๋ถ ๋ถํธ๊ฐ๊ณผ ๊ฒฝ๋ จ์ ํธ์ํฉ๋๋ค. ์ฒด์จ์ 98.6ยฐ F (37ยฐ C), ํธํก์๋ 15/min, ๋งฅ๋ฐ์ 67/min, ํ์์ 122/98 mm Hg์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ํน์ด ์ฌํญ์ด ์์ต๋๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค:
Hb% 13 gm/dL
์ด ๋ฐฑํ๊ตฌ ์ (WBC): 13,400/mm3
๊ฐ๋ณ ๊ณ์ฐ:
ํธ์ค๊ตฌ: 80%
๋ฆผํ๊ตฌ: 15%
๋จํต๊ตฌ: 5%
ESR: 33 mm/hr
๊ฐ์ฅ ์ ๋ ฅํ ์ง๋จ์ ๋ฌด์์
๋๊น? | C. difficile colitis | {
"A": "๊ถค์์ฑ ๋์ฅ์ผ",
"B": "C. difficile ๋์ฅ์ผ",
"C": "๊ณผ๋ฏผ์ฑ ๋์ฅ ์ฆํ๊ตฐ",
"D": "์ง์๋ฅด๋์์ฆ"
} | step2&3 | B | [
"58 year old female",
"treated",
"medical floor",
"community-acquired pneumonia",
"levofloxacin",
"watery diarrhea",
"reports",
"episodes",
"diarrhea",
"last two days",
"lower abdominal discomfort",
"cramping",
"temperature",
"98",
"F",
"respiratory rate",
"min",
"pulse",
"67 min",
"blood pressure",
"98 mm Hg",
"physical examination",
"unremarkable",
"Laboratory testing shows",
"Hb",
"gm dL Total count",
"WBC",
"400 mm3 Differential count",
"Neutrophils",
"80",
"Lymphocytes",
"Monocytes",
"5",
"ESR",
"mm",
"most likely diagnosis"
] | 00000000000000000263 |
7์ธ ์ฌ์๊ฐ ์ ๊ธฐ ๊ฒ์ง์ ์ํด ์ฃผ์น์์๊ฒ ๋ด์ํ์ต๋๋ค. ์ฃผ์น์๋ ์๋์์๊ฒ ์ ์ฒด ๊ฒ์ฌ๋ฅผ ์ํํ๋๋ก ํ์ฉํฉ๋๋ค. ์๋์์ ์ฒญ๋ ฅ ์์๊ณผ ํจ๊ป ๊ทธ๋ฆผ A์ B์์ ๋ณด์ด๋ ์๊ฒฌ์ ํ์ธํฉ๋๋ค. ๋ฐฉ์ฌ์ ์ฌ์ง์ ์น์ ๋ ์์๊ณจ์ ์ฌ๋ฌ ์ค๋๋ ๊ณจ์ ์งํ๋ฅผ ๋ณด์ฌ์ค๋๋ค. ์๋์์ ์ฌ์์ ๋ถ๋ชจ์๊ฒ ์ง๋ฌธํ ํ ํ์๊ฐ ์์์ ๋งค์ฐ ๊น๋ค๋กญ๊ณ ์ฃผ๋ก ์๋ฆฌ์ผ๊ณผ ํ์คํ๋ก ๊ตฌ์ฑ๋ ์๋จ์ ์ญ์ทจํ๋ค๋ ์ฌ์ค์ ์๊ฒ ๋ฉ๋๋ค. ํ์ ์งํ์ ๊ฐ์ฅ ์ ๋ ฅํ ๋ณ์ธ์ ๋ฌด์์
๋๊น? | Deficiency of type 1 collagen | {
"A": "Decreased bone mineral density",
"B": "Defective mineralization of cartilage",
"C": "Deficiency of type 1 collagen",
"D": "Dietary deficiency of ascorbic acid"
} | step2&3 | C | [
"year old girl presents",
"primary care physician",
"routine check-up",
"physician allows",
"medical student to perform",
"physical examination",
"medical student notes hearing impairment",
"findings show",
"Radiographs show indications of multiple old fractures",
"humerus",
"healed",
"questioning",
"girls parents",
"medical student learns",
"addition",
"patient",
"extremely",
"food",
"eats",
"diet consisting",
"cereal",
"pasta",
"most likely etiology",
"patients disease"
] | 00000000000000000264 |
47์ธ ๋จ์๊ฐ ๋ฉฐ์น ๋์ ๋ณตํต๊ณผ ์
์ทจ๊ฐ ๋๋ ์ค์ฌ๋ก ์์ฌ๋ฅผ ์ฐพ์๋ค. ๊ทธ๋ ๋ฉ์ค๊บผ์, ๊ตฌํ , ๋๋ ๋๋ณ ๋ด ํ์ก์ ๋ณด์ธ ์ ์ด ์๋ค. ๊ทธ๋ ์์ฝ์ฌ ์ฌ์ฉ ์ฅ์ ์ ๋ณ๋ ฅ์ด ์์ผ๋ฉฐ, ์ต๊ทผ ํ๋ ด์ผ๋ก 7์ผ ์ฝ์ค์ clindamycin ์น๋ฃ๋ฅผ ์๋ฃํ๋ค. ๊ทธ๋ ๋ฏธ๊ตญ ๋ฐ์ผ๋ก ์ฌํํ ์ ์ด ์๋ค. ์ด ํ์์ ์ฆ์ ๋ฐ๋ณ ๊ธฐ์ ์ ๊ด์ฌํ ๊ฐ๋ฅ์ฑ์ด ๊ฐ์ฅ ๋์ ๋
์๋ ๋ค์ ์ค ๋ฌด์์ธ๊ฐ? | Clostridioides difficile cytotoxin | {
"A": "Shiga toxin",
"B": "Cholera toxin",
"C": "Cereulide toxin",
"D": "Clostridioides difficile cytotoxin"
} | step1 | D | [
"year old man",
"physician",
"abdominal pain",
"smelling",
"watery diarrhea",
"days",
"not",
"nausea",
"vomiting",
"blood in",
"stool",
"history of alcohol use disorder",
"recently completed",
"7-day course",
"clindamycin",
"pneumonia",
"not traveled out of",
"United States",
"following toxins",
"most likely to",
"involved",
"pathogenesis",
"patient's symptoms"
] | 00000000000000000265 |
6์ธ ๋จ์ ํ์๊ฐ ์ง๋ ํ ๋ฌ ๋์ ๋จ์ผ ์ฆ์ ์ผ๋จ์ฆ์ผ๋ก ์ธํด ํด๋ฆฌ๋์ ๋ด์ํ์ต๋๋ค. ์๋ณ ๊ฒ์ฌ, ์์ธํ ํ์ ๋ณ๋ ฅ, ์ด์ ๋ฐฉ๋ฌธ ์์ ์๋ถ ์ญ์ทจ, ๋๋ณ, ๋ฐฐ๋จ ์ผ๊ธฐ ๋ชจ๋ ์ด์์ด ์๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ์ต๋๋ค. ๋ถ๋ชจ์ ์์ด๋ ๊ต์ก ๋ฐ ํ๋ ์น๋ฃ๋ฅผ ์ํด ์๋ขฐ๋์์ต๋๋ค. ์ผ๋จ์ฆ์ ๊ฐ์ํ์ง๋ง ์ง์๋ฉ๋๋ค. ํ์์ ๊ทธ์ ์ด๋จธ๋ ๋ชจ๋ ์ฐ๋ ค๋ฅผ ํ๋ช
ํ๋ฉฐ ์ด ๋ฌธ์ ๊ฐ ๊ฐ๋ฅํ ํ ๋นจ๋ฆฌ ํด๊ฒฐ๋๊ธฐ๋ฅผ ์ํฉ๋๋ค. ๋ค์ ์ค ๊ด๋ฆฌ์ ์์ด ๊ฐ์ฅ ์ ์ ํ ๋ค์ ๋จ๊ณ๋ ๋ฌด์์
๋๊น? | Enuresis alarm | {
"A": "Behavioral therapy",
"B": "DDAVP",
"C": "Enuresis alarm",
"D": "Oxybutynin"
} | step2&3 | C | [
"year old boy presents",
"clinic",
"of",
"enuresis",
"past month",
"Urinalysis",
"detailed patient history",
"fluid intake",
"stool",
"voiding diary",
"previous visit",
"show",
"abnormalities",
"parent",
"child",
"referred",
"education",
"behavioral therapy",
"Enuresis decreases",
"patient",
"mother",
"concern",
"issue to resolve",
"possible",
"following",
"most appropriate next step",
"management"
] | 00000000000000000266 |
๊ตฌ๊ธ์ฐจ์ ์ํด 32์ธ ๋
ธ์ ์ฌ์ฑ ํ์๊ฐ ์๊ธ์ค๋ก ์ด์ก๋์์ผ๋ฉฐ, ๊ฒฝ์ฐฐ์ด ๋ณด๋์์ ๊ทธ๋
๋ฅผ ๋ฐ๊ฒฌํ ์ง 30๋ถ ํ์๋ค. ๋์ฐฉ ๋น์ ๊ทธ๋
๋ ๋ฐ์์ด ์์๋ค. ๋งฅ๋ฐ์ ๋ถ๋น 76ํ, ํธํก์๋ ๋ถ๋น 6ํ, ํ์์ 110/78 mm Hg์๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ ํผ๋ถ๋ ์ฐจ๊ฐ๊ณ ๊ฑด์กฐํ๋ค. ๋๊ณต์ ์ถ๋๋์๊ณ ๋น์ ๋๋ฆฌ๊ฒ ๋ฐ์ํ๋ค. ์ฝ๋ฌผ์ ์ ๋งฅ ํฌ์ฌ๊ฐ ์์๋์๋ค. ์น๋ฃ ์์ 2๋ถ ํ, ํ์๋ ์์์ ํ๋ณตํ๊ณ ํธํก์๋ ๋ถ๋น 12ํ๋ก ์ฆ๊ฐํ๋ค. ํฌ์ฌ๋ ์ฝ๋ฌผ์ ๋ค์ ์์ฉ์ฒด ์ค ์ด๋ค ์์ฉ์ฒด์ ๊ฐ์ฅ ๊ฐ๋ ฅํ ์ํฅ์ ๋ฏธ์น๋๊ฐ? | ฮผ-receptor | {
"A": "Ryanodine receptor",
"B": "ฮผ-receptor",
"C": "GABAA receptor",
"D": "5-HT2A receptor"
} | step1 | B | [
"year old homeless woman",
"brought",
"emergency department",
"ambulance 30 minutes",
"police found",
"sidewalk",
"arrival",
"unresponsive",
"pulse",
"76 min",
"respirations",
"min",
"blood pressure",
"mm Hg",
"Examination shows cool",
"dry skin",
"pupils",
"pinpoint",
"light",
"Intravenous",
"drug",
"initiated",
"Two minutes after treatment",
"started",
"patient regains consciousness",
"respirations increase",
"min",
"drug",
"administered",
"strongest effect",
"following receptors"
] | 00000000000000000267 |
ํ ๊ฐ์ผ๋ณ ์กฐ์ฌ๊ด์ด ์ด์ ์ Bacillus Calmette-Guรฉrin (BCG) ๋ฐฑ์ ์ ์ ์ข
๋ฐ์ ํ์์์ ๊ฒฐํต ์ง๋จ์ ์ํ ์๋ก์ด interferon-gamma ๊ธฐ๋ฐ ๊ฒ์ฌ์ ์ง๋จ ์ ํ๋๋ฅผ ํ๊ฐํ๊ณ ์์ต๋๋ค. BCG ๋ฐฑ์ ์ ์ข
์ด๋ ฅ์ด ์๋ ๋์ํ ์ฐธ๊ฐ์๋ค์ interferon-gamma ๊ฒ์ฌ๋ฅผ ๋ฐ์๊ณ ์ดํ ๊ฐ๋ ๋ฐฐ์์ ํตํด ๊ฒฐํต์ ๋ํด ํ๊ฐ๋์์ต๋๋ค. ์ฐ๊ตฌ ๊ฒฐ๊ณผ๋ ์๋ ํ์ ์์ฝ๋์ด ์์ต๋๋ค.
๊ฒฐํต, ๋ฐฐ์์ผ๋ก ํ์ธ๋จ ๋น๊ฒฐํต ์ด๊ณ
์์ฑ interferon-gamma ๊ฒ์ฌ 90 6 96
์์ฑ interferon-gamma ๊ฒ์ฌ 10 194 204
์ด๊ณ 100 200 300
์ด๋ฌํ ๊ฒฐ๊ณผ๋ฅผ ๋ฐํ์ผ๋ก, ๋ณธ ์ฐ๊ตฌ์์ ๊ฒฐํต ์ง๋จ์ ์ํ interferon-gamma ๊ธฐ๋ฐ ๊ฒ์ฌ์ ๋ฏผ๊ฐ๋๋ ์ผ๋ง์
๋๊น?" | 90/100 | {
"A": "194/200",
"B": "90/100",
"C": "90/96",
"D": "194/204"
} | step1 | B | [
"infectious disease investigator",
"evaluating",
"diagnostic accuracy",
"new interferon-gamma based assay",
"diagnosing tuberculosis",
"patients",
"received",
"Bacillus Calmette",
"vaccine",
"Consenting participants",
"history of BCG vaccination received",
"interferon-gamma assay",
"evaluated",
"tuberculosis",
"sputum culture",
"Results",
"study",
"table",
"Tuberculosis",
"confirmed by culture",
"tuberculosis Total Positive interferon-gamma assay 90",
"Negative",
"100",
"Based",
"results",
"sensitivity",
"interferon-gamma based assay",
"diagnosis",
"tuberculosis",
"study"
] | 00000000000000000268 |
๋ฏธ๊ตญ ๋ด ํ ์ง์ญ ๋ณ์์ ์ฌ๋ฌ ํ์๋ค์ด ๋ง์ฑ ๋ถ๋น์ฑ ์ค์ฌ ์ฆ์ธ๋ฅผ ๋ณด์
๋๋ค. ์ด ํ์๋ค์๊ฒ ๋ํ๋๋ ์ค์ฌ์ ์ ์ฌ์ ์์ธ์ ๋ค์ํ์ง๋ง, ๋ค์ ์ค ๋ง์ฑ ๋ถ๋น์ฑ ์ค์ฌ์ ๊ฐ์ฅ ํํ ์์ธ์ผ๋ก ์ถ์ ๋๋ ๊ฒ์ ๋ฌด์์
๋๊น? | Medications | {
"A": "Lymphocytic colitis",
"B": "Medications",
"C": "Lactose intolerance",
"D": "Carcinoid tumor"
} | step1 | B | [
"Several patients",
"local",
"hospital present",
"chronic secretory",
"multiple potential causes",
"diarrhea present",
"patients",
"following",
"most likely",
"common cause",
"chronic secretory"
] | 00000000000000000269 |
๊ฒธ์ ์ ํ๊ตฌ ์งํ์ ์๊ณ ์๊ณ ์์ 39์ฃผ ๋ 27์ธ ์ฌ์ฑ์ด ํ๋ฐํ ๋ถ๋ง ์ค ์๊ธ์ค๋ก ์ด์ก๋์์ต๋๋ค. ๊ทธ๋
๋ ๊ธ์ฑ ํ๋ถ ์ฆํ๊ตฐ์ ์ฌ๋ฌ ๋ฒ ๊ฒช์๊ณ ๊ณผ๊ฑฐ์ ์ฌ๋ฌ ์ฐจ๋ก ์ํ์ ๋ฐ์์ผ ํ์ต๋๋ค. ๊ทธ๋
๋ ์ฐํ ์ถํ๋ก ์ธํด ์ง ๋ถ๋ง์ด ๊ธธ์ด์ก๊ณ , ๋์ถ ์ ํ๊ตฌ 1๋จ์๋ฅผ ์ํ๋ฐ์ต๋๋ค. ํ ์๊ฐ ํ, ํ์๋ ๊ธ์ฑ ์๊ตฌ๋ฆฌ ํต์ฆ์ ๊ฒช์ต๋๋ค. ๊ทธ๋
์ ์ฒด์จ์ 38.7ยฐC (101.6ยฐF), ๋งฅ๋ฐ์ 115/๋ถ, ํธํก์ 24/๋ถ, ํ์์ 95/55 mm Hg์
๋๋ค. Foley catheter๋ ์ง์ ๊ฐ์ ์๋ณ์ ๋ณด์ฌ์ค๋๋ค. ์ด ํ์์ ๋ํ ์ถ๊ฐ ํ๊ฐ๋ ๋ค์ ์ค ๋ฌด์์ ๋ณด์ฌ์ค ๊ฐ๋ฅ์ฑ์ด ๊ฐ์ฅ ๋์ต๋๊น? | Positive direct Coombs test | {
"A": "Serum antibodies against class I HLA antigens",
"B": "Positive direct Coombs test",
"C": "Positive blood cultures",
"D": "Low levels of serum IgA immunoglobulins"
} | step1 | B | [
"27 year old woman",
"sickle cell disease",
"weeks",
"gestation",
"brought",
"emergency department",
"active labor",
"multiple episodes of acute chest syndrome",
"required",
"transfusions",
"past",
"prolonged vaginal delivery complicated",
"postpartum bleeding",
"receives",
"transfusion of",
"packed red blood cells",
"One hour later",
"patient experiences acute flank",
"temperature",
"pulse",
"min",
"respirations",
"min",
"blood pressure",
"95 55 mm Hg",
"Foley catheter shows dark",
"Further evaluation",
"patient",
"most likely to show",
"following"
] | 00000000000000000270 |
17์ธ ๋จ์ฑ์ด ๋ํ ์
ํ ์ ๊ฑด๊ฐ ์ง๋จ์ ์์ฑ์ ์ํด ์ด๋จธ๋์ ํจ๊ป ์์๊ณผ ์์ฌ๋ฅผ ๋ฐฉ๋ฌธํฉ๋๋ค. ์ง๋ฃ ์ค ์ด๋จธ๋๋ ๋ํ์์ ์๋ค์ด ์ฃผ์ํด์ผ ํ ๊ฑด๊ฐ ์ํ ์์์ ๋ํด ์ง๋ฌธํฉ๋๋ค. ํนํ ์ต๊ทผ ๋ด์ค์์ ์ผ๋ถ ๋ํ์๋ค์ด ์น๋ช
์ ์ธ ๊ตํต์ฌ๊ณ ๋ก ์ฌ๋งํ๋ค๋ ์์์ ์ ํ์ต๋๋ค. ๋ฐ๋ผ์ ์ด ์ฐ๋ น๋์ ์ฌ๋ง ์์ธ์ ๋ํด ์ง๋ฌธํฉ๋๋ค. ๋ค์ ์ค ๋ํ์ ์ฐ๋ น๋์ ์ฌ๋ง ์์ธ์ ๋ํด ์ณ์ ๊ฒ์ ๋ฌด์์
๋๊น? | More of them die from homicide than cancer | {
"A": "์์ด๋ก ์ฌ๋งํ๋ ์ฌ๋์ด ๋ถ์์ผ๋ก ์ฌ๋งํ๋ ์ฌ๋๋ณด๋ค ๋ ๋ง์ต๋๋ค.",
"B": "ํ์ด๋ก ์ฌ๋งํ๋ ์ฌ๋์ด ์์ด๋ก ์ฌ๋งํ๋ ์ฌ๋๋ณด๋ค ๋ ๋ง์ต๋๋ค.",
"C": "์์ผ๋ก ์ฌ๋งํ๋ ์ฌ๋์ด ์์ด๋ก ์ฌ๋งํ๋ ์ฌ๋๋ณด๋ค ๋ ๋ง์ต๋๋ค.",
"D": "ํ์ด๋ก ์ฌ๋งํ๋ ์ฌ๋์ด ์์ผ๋ก ์ฌ๋งํ๋ ์ฌ๋๋ณด๋ค ๋ ๋ง์ต๋๋ค."
} | step1 | D | [
"year old man",
"brought",
"mother",
"pediatrician",
"order to complete medical clearance forms prior to attending college",
"visit",
"mother",
"health risks",
"aware",
"college",
"recently saw",
"news",
"college students",
"killed",
"fatal car crash",
"causes of death",
"population",
"following",
"true",
"causes of death",
"college age individuals"
] | 00000000000000000271 |
๊ทธ๋ฆฌ์ค์์ ์ด๋ฏผ ์จ ๋ถ๋ชจ์๊ฒ์ ํ์ด๋ 7๊ฐ์ ๋ ๋จ์์์ด๊ฐ ์ฐฝ๋ฐฑํจ๊ณผ ๋ณต๋ถ ํฝ๋ง์ผ๋ก ๋ณ์์ ๋ด์ํ์ต๋๋ค. ๋ถ๋ชจ๋ ์ต๊ทผ ์ค๋๋ ์ํํธ ๊ฑด๋ฌผ๋ก ์ด์ฌํ์ผ๋ฉฐ ์๋ค์ ๋ฒฝ์์ ๋จ์ด์ง ํ์ธํธ ์กฐ๊ฐ์ ๋
ธ์ถ๋ ๊ฒ์ ๋ํด ์ฐ๋ คํ๊ณ ์๋ค๊ณ ์ธ๊ธํ์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ํ์๋ ๊ฐ๋น๋ ๋ฐ ์ ๋๊ณจ ์ต๊ธฐ๋ฅผ ๋ณด์ด๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ์ต๋๋ค. Hemoglobin electrophoresis ๊ฒฐ๊ณผ HbF ๋ฐ HbA2 ์์น๊ฐ ํ์ ํ ์ฆ๊ฐํ ๊ฒ์ผ๋ก ๋ํ๋ฌ์ต๋๋ค. ๋ง์ด ํ์ก ๋๋ง ๊ฒ์ฌ์์ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์๊ฒฌ์ ๋ฌด์์ผ๊น์? | Microcytosis and hypochromasia of erythrocytes | {
"A": "Basophilic stippling of erythrocytes",
"B": "Microcytosis and hypochromasia of erythrocytes",
"C": "Schistocytes and normocytic erythrocytes",
"D": "Sickling of erythrocytes"
} | step2&3 | B | [
"month old boy",
"born",
"immigrant parents",
"Greece",
"presents",
"hospital",
"pallor",
"abdominal distention",
"parents note",
"recently moved",
"old apartment building",
"concerned",
"son's exposure",
"chipped paint",
"walls",
"physical exam",
"patient",
"found to",
"hepatosplenomegaly",
"frontal skull bossing",
"Hemoglobin electrophoresis reveals markedly increased HbF",
"HbA2 levels",
"most likely findings",
"peripheral blood smear"
] | 00000000000000000272 |
51์ธ ์ฌ์ฑ ํ์๊ฐ ์ ์ฐจ ์ฌํด์ง๋ ์ํต์ ์ฃผ์๋ก ๋ด์ํ์ต๋๋ค. ํต์ฆ์ ์ค๋ฅธ์ชฝ ๋ค๋ฆฌ๋ฅผ ๋ฐ๋ผ ๋ฐ์ ์ธ์ธก์ผ๋ก ๋ฐฉ์ฌ๋ฉ๋๋ค. ์ธ์, ์์ค๊ธ, ๋ฐ์ด์ ์์ต๋๋ค. ์์ถ MRI๋ L5-S1 ๋ ๋ฒจ์์ ์ถ๊ฐํ ํดํ ๋ฐ ํ์ถ์ ๋ณด์
๋๋ค. ๋ค์ ์ค ์ ์ฒด ๊ฒ์ฌ์์ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์๊ฒฌ์ ๋ฌด์์
๋๊น? | Weak achilles tendon reflex | {
"A": "๋ฐ ๋ค๊ฟ์น๋ก ๊ฑท๊ธฐ ์ด๋ ค์",
"B": "๊ณผ์ฅ๋ ์ฌ๊ฐ๊ฑด ๋ฐ์ฌ",
"C": "์ฝํ๋ ์ํฌ๋ ์ค๊ฑด ๋ฐ์ฌ",
"D": "๋ํด ์ ์ธ์ธก์ ๊ฐ๊ฐ ๊ฐ์"
} | step1 | C | [
"year old woman",
"physician",
"worsening lower back pain",
"pain radiates",
"right leg",
"lateral side of",
"foot",
"trauma",
"urinary incontinence",
"fever",
"MRI of",
"lumbar spine shows disc degeneration",
"herniation",
"level",
"following",
"most likely finding",
"physical examination"
] | 00000000000000000273 |
52์ธ ์ฌ์ฑ์ด 4๊ฐ์๊ฐ ์ ์ง์ ์ผ๋ก ์
ํ๋๋ ์ฐ์ธก ์๊ฐ๋ฝ ํต์ฆ ๋ฐ ๊ฒฝ์ง์ ์ฃผ์๋ก ๋ด์ํ์์ผ๋ฉฐ, ์ฆ์์ ํ๋ฃจ๊ฐ ๋๋ ๋ฌด๋ ต์ ๋์ฑ ์ฌํด์ง๋๋ค. ๊ทธ๋
๋ ๋ฏธ์ฉ์ฌ๋ก ์ผํ๋ฉฐ ์์ ์ฌ๊ธฐ ์ํด ์์ฃผ ํด์์ ์ทจํด์ผ ํฉ๋๋ค. ๊ทธ๋
๋ ๊ณ ํ์์ด ์์ผ๋ฉฐ, ์ด๋ฅผ ์ํด hydrochlorothiazide๋ฅผ ๋ณต์ฉํ๊ณ ์์ต๋๋ค. 2์ฃผ ์ , ์๋ก ๊ฐ์ผ์ผ๋ก ๊ฒฝ๊ตฌ ํญ์์ ์น๋ฃ๋ฅผ ์๋ฃํ์ต๋๋ค. ๊ทธ๋
์ ์๋งค๋ ์ ์ ์ฑ ํ๋ฐ ๋ฃจํธ์ค๋ฅผ ์๊ณ ์์ต๋๋ค. ๊ทธ๋
๋ ๋งค์ผ ๋งฅ์ฃผ๋ฅผ ํ๋ ์ ๋ง์๋ฉฐ, ์ฃผ๋ง์๋ ๊ฐ๋ ๋ ๋ง์ด ๋ง์ญ๋๋ค. ์ง๋ 2์ฃผ ๋์ ๊ด์ ํต์ ํ์์ ๋ฐ๋ผ ibuprofen์ ๋ณต์ฉํด ์์ต๋๋ค. ํ๋ ฅ ์งํ๋ ์ ์ ๋ฒ์ ๋ด์ ์์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ, ์ฐ์ธก ์ฒซ ๋ฒ์งธ ์ค์์ง ๊ด์ ๋ฟ๋ง ์๋๋ผ ์ฐ์ธก ์์ ๋ ๋ฒ์งธ ๋ฐ ๋ค ๋ฒ์งธ ์์ ์ง๊ณจ๊ฐ ๊ด์ ์์ ๋ถ์ข
, ๊ด์ ์ ์ํต ๋ฐ ์ด๋ ๋ฒ์ ๊ฐ์๊ฐ ๋ํ๋ฉ๋๋ค. ์ฐ์ธก ์์ ๋ ๋ฒ์งธ ๋ฐ ๋ค ๋ฒ์งธ ์์ ์ง๊ณจ๊ฐ ๊ด์ ์๋ก ๋๋ ทํ๊ณ ๋จ๋จํ๋ฉฐ ๊ฒฝ๋ฏธํ ์ํต์ด ์๋ ๋ถ์ข
์ด ์ด์ง๋ฉ๋๋ค. ๋ค์ ์ค ์ด๋ฌํ ์๊ฒฌ์ ๋ํ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ ์๋ ๊ทผ๋ณธ์ ์ธ ๊ธฐ์ ์ ๋ฌด์์
๋๊น? | Degenerative disease of the joints | {
"A": "Bacterial infection of the joint space",
"B": "Autoimmune-mediated cartilage erosion",
"C": "Degenerative disease of the joints",
"D": "Calcium pyrophosphate dihydrate crystal precipitation in the joints"
} | step2&3 | C | [
"year old woman",
"physician",
"4 month history",
"progressive pain",
"stiffness of",
"fingers",
"right hand",
"worse",
"end",
"day",
"works",
"hair dresser",
"to take frequent breaks to rest",
"hand",
"hypertension",
"takes hydrochlorothiazide",
"Two weeks",
"completed",
"course",
"oral antibiotics",
"urinary tract infection",
"sister",
"systemic lupus erythematosus",
"drinks one",
"two beers daily",
"occasionally",
"weekends",
"past 2 weeks",
"taking ibuprofen as needed",
"joint pain",
"vital signs",
"normal",
"Physical examination shows swelling",
"joint line tenderness",
"decreased range of motion",
"right first metacarpophalangeal joint",
"2nd",
"4th distal interphalangeal joints of the right hand",
"Discrete",
"hard",
"mildly tender swellings",
"palpated",
"2nd",
"4th distal interphalangeal joints of the right hand",
"following",
"most likely underlying mechanism",
"findings"
] | 00000000000000000274 |
51์ธ ๋จ์ฑ์ด ์ฌํ ๊ตฌ๋ด์ผ๊ณผ ๋ชธํต์ ์์ ํผ๋ถ ๋ฏธ๋์ผ๋ก ํผ๋ถ๊ณผ์ ๋ด์ํ์ต๋๋ค. ๊ทธ์ ์ํ๋ 2๊ฐ์ ์ ์ ์์๋์์ผ๋ฉฐ ๊ฒฝ๊ตฌ์ฉ ํญ์์ ๋ฐ ํญํค๋ฅดํ์ค ์ฝ๋ฌผ์ ๋ฐ์ํ์ง ์์์ต๋๋ค. ๊ทธ๋ ์ ์ฌํ ๋ฐ์ง์ ๋ณ๋ ฅ์ด ์์ต๋๋ค. ๊ทธ์ ๋ณ๋ ฅ์ ์ 2ํ ๋น๋จ๋ณ๊ณผ ๋ณธํ์ฑ ๊ณ ํ์์ผ๋ก ํน์ง์ง์ด์ง๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ, ์ฝ๊ฒ ํ์ด๋๋ ๋ค์์ ์ฐ์ฑ ์ํฌ์ ๋ฌผ์ง์ด ๋ํ๋ฌ์ต๋๋ค. ๋์ฝ์คํค ์งํ๋ ์์ฑ์
๋๋ค. ๋ค์ ์ค ์ด ํ์์ ์ํ์ ๋ณ์ธ์ ๊ฐ์ฅ ์ ๋ํ๋ด๋ ๊ฒ์ ๋ฌด์์
๋๊น? | Anti-desmoglein-3 antibodies | {
"A": "๊ธฐ์ ๋ฐ ์๊ธฐ์ ์ธํฌ์ ์ฆ๊ฐ๋ ์ ์ฌ ๋ถ์ด ํ๋",
"B": "ํผ๋ถ T ์ธํฌ ๋ฆผํ์ข
",
"C": "ํญ๋ฐ์ค๋ชจ๊ธ๋ ์ธ-3 ํญ์ฒด",
"D": "ํผ๋ถ์ฌ์๊ท ๊ฐ์ผ"
} | step2&3 | C | [
"year old man presents",
"dermatologist",
"severe stomatitis",
"superficial skin",
"trunk",
"condition started 2 months",
"unresponsive",
"oral antibiotics",
"medications",
"history",
"similar rash",
"medical history",
"type 2 diabetes mellitus",
"essential hypertension",
"physical examination reveals numerous flaccid",
"bullae",
"rupture easily",
"Nikolsky's sign",
"positive",
"following best represents",
"etiology",
"patients condition"
] | 00000000000000000275 |
50์ธ ๋จ์ฑ์ด ์ ๊ธฐ ๊ฒ์ง์ ์ํด ์ฃผ์น์๋ฅผ ๋ฐฉ๋ฌธํ์ต๋๋ค. ๊ทธ๋ ์ ๋ฐ์ ์ผ๋ก ์ ์ง๋ด๊ณ ์์ผ๋ฉฐ ๋ณ๋ค๋ฅธ ๋ถํธํ ์ฆ์์ ์๋ค๊ณ ๋ณด๊ณ ํ์ต๋๋ค. ๊ทธ์ ๊ณผ๊ฑฐ ๋ณ๋ ฅ์ ๋ก์ฌ๋ฅดํ์ผ๋ก ์ ์กฐ์ ๋๊ณ ์๋ ๊ณ ํ์ ์ธ์๋ ํน์ด ์ฌํญ์ด ์์ต๋๋ค. ํ๋ ฅ ์งํ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค: T 37.0 C, HR 80, BP 128/76, RR 14, SpO2 99%. ์ ์ฒด ๊ฒ์ฌ์์ ํน๋ณํ ์ด์ ์๊ฒฌ์ ๋ฐ๊ฒฌ๋์ง ์์์ต๋๋ค. ์์ฌ๋ ์ด๋ฒ ๋ฐฉ๋ฌธ์์ ํ์์ ๋๋ณ์ ์ ์ฌ์ ์ธ ๋์ฅ์์ ์์ฌํ ์ ์๋ ํ์ก ์ ๋ฌด๋ฅผ ์ ๋ณํ๊ธฐ ์ํด ๋ถ๋ณ ์ ํ ๊ฒ์ฌ๋ฅผ ๊ถ์ ํฉ๋๋ค. ๋ค์ ์ค ์ง๋ณ ์๋ฐฉ์ ์ด ๋ฐฉ๋ฒ์ ๊ฐ์ฅ ์ ์ค๋ช
ํ๋ ๊ฒ์ ๋ฌด์์
๋๊น? | Secondary prevention | {
"A": "์์ ์๋ฐฉ",
"B": "์ผ์ฐจ ์๋ฐฉ",
"C": "์ด์ฐจ ์๋ฐฉ",
"D": "์ผ์ฐจ ์๋ฐฉ"
} | step1 | C | [
"50 year old male presents",
"primary care physician",
"routine check-up",
"reports",
"well overall",
"symptoms",
"past medical history",
"significant only",
"hypertension",
"well controlled",
"losartan",
"Vital signs",
"follows",
"T",
"0",
"80",
"BP",
"76",
"RR",
"99",
"Physical examination",
"not reveal",
"concerning abnormalities",
"physician recommends",
"fecal occult blood test",
"visit to screen",
"presence",
"blood",
"patient's stool",
"suggestive of",
"underlying colorectal cancer",
"following best",
"method",
"disease prevention"
] | 00000000000000000276 |
57์ธ ๋จ์ฑ์ด ์ผ์ชฝ ํ ์๋์ชฝ๊ณผ ๋ชฉ ์ผ์ชฝ์ผ๋ก ๋ฐฉ์ฌ๋๋ ๊ฐ์ด ์ค์์ ํต์ฆ์ผ๋ก ์ธํด ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ํต์ฆ์ 30๋ถ ์ ํ์๊ฐ ์ง์ฅ์ ์๋ ๋์ ๊ฐ์๊ธฐ ์์๋์์ต๋๋ค. ํ์๋ ํต์ฆ์ ์ฑ๊ฒฉ์ ์ฅ์ด์ง๋ ๋ฏํ๋ฉฐ ๊ฐ๋๋ 10/10์ด๊ณ , ๋ฉ์ค๊บผ์๊ณผ ํธํก ๊ณค๋์ด ๋๋ฐ๋๋ค๊ณ ์ค๋ช
ํฉ๋๋ค. ๊ทธ๋ 15๋
๋์ ์ 2ํ diabetes mellitus, 10๋
๋์ hypertension, ๊ทธ๋ฆฌ๊ณ dyslipidemia๋ฅผ ์์์ง๋ง, ์ฌ์ฅ ๋ฌธ์ ๋ณ๋ ฅ์ ๋ถ์ธํฉ๋๋ค. ๊ทธ๋ 40 pack-year์ ํก์ฐ๋ ฅ์ด ์์ง๋ง ์ ์ ๋ง์์ง ์์ต๋๋ค. ํ๋ ฅ ์งํ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค. ํ์ 80/40 mm Hg, ๊ท์น์ ์ธ ๋งฅ๋ฐ 90/min, ์ฒด์จ 37.2ยฐC(98.9ยฐF). ํ๋ถ ์ฒญ์ง ๊ฒฐ๊ณผ murmurs๋ ์์ง๋ง ์์ชฝ ํ์์ ๋ฏธ๋ง์ฑ ์ํฌ์์ด ๋ํ๋ฉ๋๋ค. ECG๋ ์ ๋ V1์์ V6๊น์ง ๋ณผ๋กํ ST-segment elevation์ ๋ณด์ฌ์ฃผ๊ณ echocardiogram์ ์ ์ธ์ธก ์ด๋์ ํ, ์ข์ฌ๋ฐฉ์ผ๋ก์ ์ญ๋ฅ ํ๋ฅ, ๊ทธ๋ฆฌ๊ณ ejection fraction 45%๋ฅผ ๋ณด์ฌ์ค๋๋ค. ๋ค์ ์ค ์ด ํ์์ ์ง๋ณ ๋ฉ์ปค๋์ฆ์ ๊ฐ์ฅ ์ ์ค๋ช
ํ๋ ๊ฒ์ ๋ฌด์์
๋๊น? | Occlusion of the left anterior descending artery with rupture of a papillary muscle | {
"A": "papillary muscle ํ์ด์ ๋๋ฐํ left anterior descending artery ํ์",
"B": "interventricular septal rupture๋ฅผ ๋๋ฐํ left anterior descending artery ํ์",
"C": "์ฌ์ค ์์ ๋ฒฝ ํ์ด",
"D": "Mitral leaflet ๋นํ ๋ฐ ์ฌ์ ํ"
} | step2&3 | A | [
"57 year old man presents",
"emergency department",
"pain",
"center",
"chest",
"radiating",
"left arm",
"left side of",
"neck",
"pain started",
"30 minutes",
"patient",
"work",
"patient",
"pain",
"squeezing",
"nature",
"10",
"intensity",
"associated with nausea",
"difficulty breathing",
"type 2 diabetes mellitus",
"years",
"hypertension",
"10 years",
"dyslipidemia",
"denies",
"history",
"cardiac problem",
"40 pack-year history of smoking",
"not drink alcohol",
"Vital signs include",
"blood pressure 80 40 mm Hg",
"regular pulse 90 min",
"temperature",
"98 9F",
"Chest auscultation reveals diffuse bilateral rales",
"murmurs",
"ECG reveals convex ST-segment elevation",
"leads V1",
"V6",
"echocardiogram shows anterolateral hypokinesis",
"retrograde blood",
"left atrium",
"ejection fraction",
"following best",
"mechanism",
"patients illness"
] | 00000000000000000277 |
29์ธ์ ์ํ๋ฆฌ์นด๊ณ ๋ฏธ๊ตญ์ธ ์ฌ์ฑ์ด ๊ทน์ฌํ ํผ๋ก์ ์์ธก ๊ด์ ํต์ฆ์ผ๋ก ๊ทํ์ ์ฌ๋ฌด์ค์ ๋ด์ํ์ต๋๋ค. ํ์ฒญ ๊ฒ์ฌ ๊ฒฐ๊ณผ ๋ฅ๋งํฐ์ค ์ธ์, anti-Smith ํญ์ฒด ๋ฐ anti-dsDNA ํญ์ฒด๊ฐ ์กด์ฌํ๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ์ต๋๋ค. VDRL ๋งค๋
๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ์์ฑ์
๋๋ค. ์๊ณ ํ๋กํ์ ์ฃผ๋ฌธํ ๊ฒฐ๊ณผ ์ ์ ์ถํ ์๊ฐ, ์ ์ PT, ์ฐ์ฅ๋ PTT ๋ฐ ์ ์ ํ์ํ ์๊ฐ ๋ํ๋ฌ์ต๋๋ค. ์ถ๊ฐ ํ๊ฐ๋ ๋ค์ ์ค ๋ฌด์์ ๋ฐํ ๊ฐ๋ฅ์ฑ์ด ๊ฐ์ฅ ๋์ต๋๊น? | History of multiple spontaneous abortions | {
"A": "Palmar rash",
"B": "HLA-B27 positivity",
"C": "Factor VIII deficiency",
"D": "๋ค๋ฐ์ฑ ์์ฐ ์ ์ฐ ๋ณ๋ ฅ"
} | step1 | D | [
"29 year old African American female presents",
"office",
"extreme fatigue",
"bilateral joint pain",
"Serologies",
"presence",
"rheumatoid factor",
"Smith",
"anti-dsDNA antibodies",
"VDRL syphilis",
"positive",
"order",
"coagulation profile",
"reveals normal bleeding time",
"normal PT",
"prolonged PTT",
"normal platelet count",
"Further evaluation",
"most likely to reveal",
"following"
] | 00000000000000000278 |
31์ธ ๋จ์ฑ์ด 5์ผ ๋์์ ๋ฐ์ด, ์คํ ๋ฐ ํธํก ๊ณค๋์ ๋ณ๋ ฅ์ผ๋ก ์์ฌ๋ฅผ ์ฐพ์์์ต๋๋ค. ๊ทธ์ ์ฒด์จ์ 38.9ยฐC (102ยฐF)์ด๊ณ ๋งฅ๋ฐ์ 90ํ/๋ถ์
๋๋ค. ์ฌ์ฅ ๊ฒ์ฌ์์ ์ก์์ด ๋ค๋ฆฝ๋๋ค. ๋ค๋ฅธ ์กฐ์น ์ธ์๋ ์ฌ์ฅ ์นดํ
ํฐ ์ฝ์
์ ์ด ์ํ๋ฉ๋๋ค. ์นดํ
ํฐ ์ฝ์
์ ๊ฒฐ๊ณผ๋ฅผ ๋ณด์ฌ์ฃผ๋ ๊ทธ๋ํ๊ฐ ํ์๋ฉ๋๋ค. ์ด ํ์๋ ๋ค์ ์ค ์ด๋ค ์ฌ์ฅ ํ๋ง ๊ฒฐ์์ ๊ฐ์ง๊ณ ์์ ๊ฐ๋ฅ์ฑ์ด ๊ฐ์ฅ ๋์ต๋๊น? | Aortic regurgitation | {
"A": "Mitral stenosis",
"B": "Mitral regurgitation",
"C": "Aortic regurgitation",
"D": "Aortic stenosis"
} | step1 | C | [
"31 year old man",
"physician",
"5-day history",
"fever",
"chills",
"dyspnea",
"temperature",
"pulse",
"90 min",
"Cardiac examination shows",
"murmur",
"measures",
"cardiac catheterization",
"performed",
"graph showing",
"results",
"catheterization",
"shown",
"patient",
"likely",
"following valvular heart defects"
] | 00000000000000000279 |
54์ธ ์ฌ์ฑ์ด 1๊ฐ์ ๋์ ์ค๋ฅธ์ชฝ ๋ค๋ฆฌ์ ๋ฐ์ํ ํต์ฆ์ฑ ํผ๋ถ ๋ณ๋ณ์ผ๋ก ์ธํด ์์ฌ๋ฅผ ์ฐพ์์์ต๋๋ค. ์ฒ์์๋ ์์ ๋ถ์ ๋ฐ์ ์ผ๋ก ์์ํ์ง๋ง ์ด ๊ธฐ๊ฐ ๋์ ํฌ๊ธฐ๊ฐ ๋น ๋ฅด๊ฒ ์ฆ๊ฐํ์ต๋๋ค. ๋ณ๋ณ์ด ๋ฐ์ํ๊ธฐ ์ ์ ๋ค๋ฆฌ์ ๊ฐ๋ฏธ์ ๋ฌผ๋ฆฐ ๊ฒ์ ๊ธฐ์ตํฉ๋๋ค. 8๊ฐ์ ์ ์ corticosteroid๋ก ์ ๋ฐฉ ํฌ๋๋ง์ผ ์น๋ฃ๋ฅผ ๋ฐ์์ต๋๋ค. Crohn's disease, ์ 2ํ diabetes mellitus, ๊ทธ๋ฆฌ๊ณ hypertension์ ์๊ณ ์์ต๋๋ค. ํ์ฌ ๋ณต์ฉ ์ค์ธ ์ฝ๋ฌผ์๋ insulin, mesalamine, enalapril, ๊ทธ๋ฆฌ๊ณ aspirin์ด ์์ต๋๋ค. 2๊ฐ์ ์ ์ ์๋ค์ ๋ฐฉ๋ฌธํ๊ธฐ ์ํด Wisconsin์์ ๋์์์ต๋๋ค. ์ฒด์จ์ 37.6ยฐC (98ยฐF), ๋งฅ๋ฐ์ 98ํ/๋ถ, ํ์์ 126/88 mm Hg์
๋๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ, ํ์ง์ ํจ์ ๋ถ์ข
(pitting pedal edema)์ด ๋ํ๋ฉ๋๋ค. ์ค๋ฅธ์ชฝ ๋ค๋ฆฌ ์์ชฝ์ ์ค์ฌ ๊ดด์ฌ ๊ธฐ์ ๋ถ์ ์์ค๋น ๋ถ๊ท์นํ ๊ฒฝ๊ณ๋ฅผ ๊ฐ์ง 4cm ํฌ๊ธฐ์ ์ํต์ฑ ๊ถค์์ฑ ๋ณ๋ณ์ด ์์ต๋๋ค. ์์ชฝ ๋ค๋ฆฌ ์๋์ชฝ์ ํ์ฅ๋๊ณ ๊ผฌ๋ถ๊ผฌ๋ถํ ์ ๋งฅ์ด ์์ต๋๋ค. ๋ํด๊ณจ ๋ฐ ์กฑ๋ถ ๋งฅ๋ฐ์ ์์ชฝ ๋ชจ๋์์ ์ด์ง๋ฉ๋๋ค. ๋ค์ ์ค ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ง๋จ์ ๋ฌด์์
๋๊น? | Pyoderma gangrenosum | {
"A": "Ecthyma gangrenosum",
"B": "Pyoderma gangrenosum",
"C": "Blastomycosis",
"D": "Basal cell carcinoma"
} | step2&3 | B | [
"54 year old woman",
"physician",
"of",
"painful skin lesion",
"right leg",
"1 month",
"initially started out",
"small red spot",
"rapidly increased in size",
"period",
"remembers",
"ant bite",
"leg",
"lesion occurring",
"treated",
"anterior uveitis",
"months",
"corticosteroids",
"Crohn's disease",
"type 2 diabetes mellitus",
"hypertension",
"Current medications include insulin",
"mesalamine",
"enalapril",
"aspirin",
"returned",
"Wisconsin",
"visiting",
"son",
"months",
"temperature",
"pulse",
"98 min",
"blood pressure",
"88 mm Hg",
"Examination shows pitting pedal edema of",
"lower extremities",
"4 cm tender ulcerative lesion",
"anterior right leg",
"central necrotic base",
"irregular borders",
"dilated tortuous veins",
"lower legs",
"Femoral",
"pedal pulses",
"palpated",
"following",
"most likely diagnosis"
] | 00000000000000000280 |
์ต๊ทผ ํ ๊ฐ์ ์ํ๊ณผ ์์ฌ๊ฐ ํ์๋ค๋ก๋ถํฐ ๋ ๋ง์ ๋ถ์ ์ ์ธ ์จ๋ผ์ธ ๋ฆฌ๋ทฐ๋ฅผ ๋ฐ๊ณ ์์ต๋๋ค. ๊ทธ๋ ์ ์ ๋ ํผ๋ก๊ฐ์ ๋๋ผ๊ณ ์์ผ๋ฉฐ ์ง๋ ํ ๋ฌ ๋์์๋ง 2๊ฑด์ ์ค์ง ์ฒ๋ฐฉ์ ๋ด๋ ธ์ต๋๋ค. ํ์ฌ ๊ทธ์ ํ์ ๋ชฉ๋ก์๋ 1,051๋ช
์ ํ์๊ฐ ์์ผ๋ฉฐ ๊ทธ ์ค ์ ๋ฐ์ ๋
ธ์ธ ํ์์
๋๋ค. ๊ทธ๋ ๋งค์ฃผ ์ฝ 51์๊ฐ์ ์๋นํ์ฌ ํ๋ฃจ์ ์ฝ 20๋ช
์ ํ์๋ฅผ ์ง๋ฃํฉ๋๋ค. ๊ทธ๋ ์ฌ๊ฐํ ์ง๋ณ ๋ณ๋ ฅ์ด ์์ผ๋ฉฐ ์ฝ๋ฌผ์ ๋ณต์ฉํ์ง ์์ต๋๋ค. ์ ์ ๊ณผ ์์ฌ์ ํ๊ฐ ๊ฒฐ๊ณผ ์ฃผ์ ์ ์ ๊ณผ์ ์ฅ์ ๋ ๋ํ๋์ง ์์์ต๋๋ค. ์ต๊ทผ์ ์ ๊ตญ ์ค๋ฌธ ์กฐ์ฌ์ ๋ฐ๋ฅด๋ฉด ์์ฌ๋ค์ ๋ค์ ์ค ์ด๋ค ์์ธ์ ์ด ์์ฌ์ ํ์ฌ ์ํ์ ๋ ์์ฃผ ๊ธฐ์ฌํ๋ค๊ณ ์ธ์ํฉ๋๊น? | Excessive bureaucratic tasks | {
"A": "The number of patients on his panel",
"B": "Excessive bureaucratic tasks",
"C": "Working too many hours",
"D": "Concern over online reputation"
} | step2&3 | B | [
"primary care physician",
"recently receiving more negative",
"reviews",
"patients",
"feeling tired",
"written 2 wrong prescriptions",
"past month alone",
"Currently",
"panel",
"list",
"patients",
"half",
"geriatric patients",
"spends",
"hours per week visiting",
"20 patients",
"day",
"history",
"serious illness",
"takes",
"medications",
"evaluation",
"psychiatrist shows",
"primary psychiatric",
"recent national surveys",
"following",
"physicians",
"frequently",
"physicians current condition"
] | 00000000000000000281 |
42์ธ ๋ฐฑ์ธ ์ฌ์ฑ ํ์๊ฐ ์ฌ๋ฌ ์ฝ๋ฌผ ํ๊ฒฝ์์์ ์ฌ์ฅ ๊ธฐ๋ฅ์ ์ฐ๊ตฌํ๊ธฐ ์ํ ๋ฌด์์ ๋์กฐ ์ํ์ ๋ฑ๋ก๋์์ต๋๋ค. ํ์๋ verapamil ํฌ์ฝ์ ์์ํ๊ณ , ์ฌ๋ฌ ์ฌ์ฅ ๋งค๊ฐ๋ณ์๋ฅผ ์ธก์ ํ๋ ๋์ VO2 max์ 50% ๊ฐ๋๋ก ์ด๋ํ๋๋ก ์ง์๋ฐ์์ต๋๋ค. ์ด ์คํ ๋์, ๋ค์ ์ค ์ฌ์ฅ์ ํตํ ์๋์ ์ธ ์ ๋ ์๋๋ฅผ ๊ฐ์ฅ ๋น ๋ฆ์์ ๋๋ฆผ ์์ผ๋ก ๋ํ๋ด๋ ๊ฒ์ ๋ฌด์์
๋๊น? | Purkinje fibers > atria > ventricles > AV node | {
"A": "์ฌ๋ฐฉ > Purkinje fibers > ์ฌ์ค > AV node",
"B": "AV node > ์ฌ์ค > ์ฌ๋ฐฉ > Purkinje fibers",
"C": "Purkinje fibers > ์ฌ๋ฐฉ > ์ฌ์ค > AV node",
"D": "Purkinje fibers > AV node > ์ฌ์ค > ์ฌ๋ฐฉ"
} | step2&3 | C | [
"year old Caucasian woman",
"enrolled",
"randomized controlled trial to study cardiac",
"setting",
"different drugs",
"started",
"verapamil",
"to exercise",
"50",
"VO2",
"several cardiac parameters",
"measured",
"experiment",
"following represents",
"relative conduction speed",
"heart",
"fastest",
"slowest"
] | 00000000000000000282 |
7์ธ ๋จ์๊ฐ 3์ผ ๋์ ์ ์ ๋ฐ์ง์ผ๋ก ์ธํด ์์ฌ๋ฅผ ์ฐพ์๋ค. ์ง๋ 5์ผ ๋์ ๊ทธ๋ ๋ํ ๊ณ ์ด๊ณผ ์ธํํต์ ๊ฒช์๋ค. ๊ทธ์ 16์ธ ๋๋๋ 2์ฃผ ์ ์ ์ ์ผ์ฑ ๋จํต๊ตฌ์ฆ์ผ๋ก ์น๋ฃ๋ฅผ ๋ฐ์๋ค. ๊ทธ๋ ์ผ์ฃผ์ผ ์ ์ ์ฌ๋ฆ ์บ ํ์์ ๋์์๋ค. ๊ทธ์ ์๋ฐฉ ์ ์ข
์ ์ต์ ์ํ์ด๋ค. 3๋
์ , ๊ทธ๋ ๋ํด๋ก์ฌ์ค๋ฆฐ์ ๋ํ ์๋ ๋ฅด๊ธฐ ๋ฐ์์ผ๋ก ๊ธฐ๊ด ์ฝ๊ด์ ์ ๋ฐ์์ผ ํ๋ค. ํ์๋ ์ํ ๋ณด์ธ๋ค. ๊ทธ์ ์ฒด์จ์ 38.2ยฐC(100.8ยฐF)์ด๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ ์
์ฃผ์ ์ฐฝ๋ฐฑ์ด ๊ด์ฐฐ๋๋ค. ๊ฒฝ๋ถ ๋ฆผํ์ ๋ณ์ฆ์ด ๋ํ๋๋ค. ํธ๋ ํ๋ฐ๊ณผ ์ผ์ถ๋ฌผ์ด ์๋ค. ๊ฑฐ์น ์ง๊ฐ์ ์ตํฉ์ฑ, ์ฐฝ๋ฐฑ์ฑ, ์ ์ ํ๋ฐ์ฑ ๋ฐ์ง์ด ๋ชธํต๊ณผ ์ฌ์ง์ ํผ์ ธ ์๋ค. ๊ทธ์ ํค๋ชจ๊ธ๋ก๋น ๋๋๋ 13.3 g/dL, ๋ฐฑํ๊ตฌ ์๋ 12,000/mm3, ์ ํ๊ตฌ ์นจ๊ฐ ์๋๋ 43 mm/h์ด๋ค. ๋ค์ ์ค ๊ฐ์ฅ ์ ์ ํ ๋ค์ ๊ด๋ฆฌ ๋จ๊ณ๋ ๋ฌด์์ธ๊ฐ? | Azithromycin therapy | {
"A": "Acyclovir therapy",
"B": "Amoxicillin therapy",
"C": "Azithromycin therapy",
"D": "Cephalexin therapy"
} | step2&3 | C | [
"year old boy",
"physician",
"of",
"generalized rash",
"3 days",
"past",
"days",
"high fever",
"sore throat",
"year old sister",
"treated",
"infectious mononucleosis 2 weeks",
"returned",
"summer camp",
"week",
"immunizations",
"date",
"Three years",
"required intubation",
"allergic reaction",
"dicloxacillin",
"patient appears ill",
"temperature",
"100",
"Examination shows circumferential oral pallor",
"Cervical lymphadenopathy",
"present",
"tonsillar erythema",
"exudate",
"confluent",
"blanching",
"punctate erythematous rash",
"texture",
"spread",
"trunk",
"extremities",
"hemoglobin concentration",
"g/dL",
"leukocyte count",
"mm3",
"erythrocyte sedimentation rate",
"mm/h",
"following",
"most appropriate next step",
"management"
] | 00000000000000000283 |
30์ธ ์ฌ์ฑ ํ์๊ฐ 5๊ฐ์ ์ ๋ถํฐ ๋ชฉ์ ๋ถ์ข
์ด ์๊ฒจ ์์ฌ๋ฅผ ์ฐพ์๋ค. ๋ถ์ข
์ ํฌ๊ธฐ๋ ์ ์ง์ ์ผ๋ก ์ปค์ก์ผ๋ฉฐ ์ฝ๊ฐ์ ํต์ฆ์ด ์๋ค. ๋ํ ์ง๋ 3๊ฐ์ ๋์ ๊ฐํ์ ์ธ ๋ฐ๋์ฑ ๋ํต, ๋ฐํ, ์ฌ๊ณํญ์ง์ด ์์๋ค. ์๊ฒฝ์ ๊ท์น์ ์ธ 28์ผ ๊ฐ๊ฒฉ์ผ๋ก ๋ฐ์ํ๋ฉฐ 4~5์ผ ๋์ ์ง์๋๋ค. ํก์ฐ์ ํ์ง ์์ผ๋ฉฐ, ์ฃผ๋ง์ ๊ฐ๋ ์ ์ ๋ง์ ๋ค. ํ์๋ ๋ง๋ฅด๊ณ ์ฐฝ๋ฐฑํด ๋ณด์ธ๋ค. ์ฒด์จ์ 38.7ยฐC (101.7ยฐF), ๋งฅ๋ฐ์ 112/min, ํ์์ 140/90 mm Hg์ด๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ, ์ผํฌ ๋ ์์ง์ด๋ ๋จ๋จํ 3cm ํฌ๊ธฐ์ ๋ชฉ ๋ถ์ข
์ด ๊ด์ฐฐ๋์๊ณ , ๋ฆผํ์ ๋ณ์ฆ์ ์๋ค. ์ฌํ ๊ฒ์ฌ์์๋ ์ด์ ์๊ฒฌ์ด ๋ณด์ด์ง ์์๋ค. ๊ฒ์ฌ์ค ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ๋ค:
Hemoglobin 13 g/dL
Leukocyte count 9500/mm3
Platelet count 230,000/mm3
Serum
Na+ 136 mEq/L
K+ 3.5 mEq/L
Cl- 104 mEq/L
TSH 2.3 ฮผU/mL
Calcitonin 300 ng/dL (์ ์ < 5 ng/dL)
์ฌ์ ๋ ๊ฒ์ฌ ๊ฒฐ๊ณผ, ๋์ฑ ๋น๋งฅ์ด ๋ํ๋ฌ๋ค. ๋ค์ ๊ฒ์ฌ ์ด์ ์๊ฒฌ ์ค ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ๊ฒ์ ๋ฌด์์ธ๊ฐ?" | Increased plasma metanephrines | {
"A": "Increased serum gastrin",
"B": "Increased serum cortisol",
"C": "Increased serum T3 levels",
"D": "Increased plasma metanephrines"
} | step2&3 | D | [
"30 year old woman",
"physician",
"of",
"swelling",
"neck",
"5 months",
"enlarged",
"size",
"mildly painful",
"intermittent episodes of throbbing",
"sweating",
"palpitations",
"past 3 months",
"Menses occur",
"regular",
"day intervals",
"last",
"days",
"not smoke",
"occasionally",
"alcohol",
"weekends",
"appears thin",
"pale",
"temperature",
"pulse",
"min",
"blood pressure",
"90 mm Hg",
"Examination shows",
"firm",
"3",
"swelling",
"neck",
"moves",
"swallowing",
"lymphadenopathy",
"Cardiopulmonary examination shows",
"abnormalities",
"Laboratory studies show",
"Hemoglobin",
"g dL Leukocyte",
"mm3 Platelet count",
"Serum",
"K",
"2",
"Calcitonin 300 ng dL",
"Normal",
"5 ng/dL",
"electrocardiogram shows sinus tachycardia",
"following laboratory abnormalities",
"most likely to",
"seen"
] | 00000000000000000284 |
37์ฃผ ์์ ์ค์ธ 31์ธ์ G3P1 ์ฌ์ฑ์ด ๋ฐ๋ณต์ ์ธ ๊ฒฝ๋ จ ํ ๋จํธ์ ์ํด ์๊ธ์ค๋ก ์ด์ก๋์์ต๋๋ค. ๋จํธ์ ๋ฐ๋ฅด๋ฉด, ๊ทธ๋ค์ TV๋ฅผ ๋ณด๊ณ ์์๋๋ฐ ๊ฐ์๊ธฐ ๊ทธ๋
๊ฐ ๋ฐ์์ด ์์ด์ง๊ณ ์๊ณผ ๋ค๋ฆฌ๊ฐ ๋จ๋ฆฌ๊ธฐ ์์ํ์ต๋๋ค. ์ด ์ฆ์์ ์ฝ 5๋ถ ๋์ ์ง์๋์๊ณ ๊ทธ๋
๋ "๊ทธ ํ ์ ๋ ๊ฒ ๊ฐ์์ต๋๋ค." ๊ทธ๋
์ ๊ณผ๊ฑฐ ๋ณ๋ ฅ์ ์์ ์ฑ ๊ณ ํ์์ด ์ฃผ์ํฉ๋๋ค. ํ์๋ ํผ๊ณคํ์ง๋ง ๋ฐ์์ ๋ณด์ด๋ฉฐ ์์ค๊ธ, ๊ฐ๊ฐ ์ด์, ๋ฐ์ด, ์๊ธฐ๋ ์งํ ๋๋ ์๋ก์ด ์ฝ๋ฌผ ๋ณ๊ฒฝ์ ๋ถ์ธํฉ๋๋ค. ๊ทธ๋
๋ ๋ฐ์ ๋ณ๋ ฅ์ ๋ถ์ธํฉ๋๋ค. ๊ทธ๋
์ ์ฒด์จ์ 99ยฐF (37ยฐC), ํ์์ 186/97 mmHg, ๋งฅ๋ฐ์ 96/min, ํธํก์๋ 12/min์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ, ์ฐ์ธก ์๋ณต๋ถ์ ์ค๋ฑ๋ ์ํต์ ๋๋ฐํ ๊ธฐ๋ฉด ์ํ์ ํ์์์ด ํ์ธ๋์์ต๋๋ค. ์ด ํ์๋ฅผ ์ํ ๊ฐ์ฅ ์ ์ ํ ๋ค์ ๋จ๊ณ๋ ๋ฌด์์
๋๊น? | Intravenous magnesium sulfate | {
"A": "Emergency cesarean section",
"B": "Expectant management",
"C": "Intravenous infusion of oxytocin",
"D": "Intravenous magnesium sulfate"
} | step1 | D | [
"31 year old",
"woman",
"weeks of gestation",
"brought",
"emergency department",
"husband",
"repeated twitching",
"husband",
"watching TV",
"unresponsive",
"hands",
"legs started shaking",
"episode lasted",
"5 minutes",
"to",
"sleeping",
"past medical history",
"significant",
"pregnancy induced hypertension",
"patient",
"tired",
"responsive",
"denies urinary incontinence",
"paresthesia",
"fever",
"upper respiratory signs",
"new medication changes",
"denies",
"history",
"seizures",
"temperature",
"blood pressure",
"97 mmHg",
"pulse",
"96 min",
"respirations",
"min",
"Physical examination demonstrates",
"lethargic patient",
"moderate right upper quadrant tenderness",
"most appropriate next step",
"patient"
] | 00000000000000000285 |
65์ธ ๋จ์ฑ์ด ์ง์ญ ์ฌํ ๋ด ๋ถ์ ์ ํ ์ฅ์์์ ์๋ณ ๋ฐ ๋ฐฐ๋ณ์ ํ์ฌ ๋ณด์ ์์์ ์ํด ๋ฐ๊ฒฌ๋์์ต๋๋ค. ์ง๋ฌธ ๊ณผ์ ์์ ๊ทธ๋ ๋ถ์พํ ๋ฐ์ธ์ ํ๊ณ ๋ถ์ ์ ํ๊ฒ ํ๋ํ์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ์์ฌ๋ ์ด๋์ค์กฐ ๋ณดํ๊ณผ ๊ธฐ์ต์์ค์ ๊ด์ฐฐํ์ต๋๋ค. ์ด๊ธฐ ์๋ณ ์ฝ๋ฌผ ๊ฒ์ฌ ๊ฒฐ๊ณผ ๋จ์ฉ ์ฝ๋ฌผ์ ๋ํ ์์ฑ ๋ฐ์์ ๋ณด์์ต๋๋ค. ์ด ํ์์๊ฒ ๋ํ๋ ๊ฐ๋ฅ์ฑ์ด ๊ฐ์ฅ ๋์ ๋ณ๋ฆฌํ์ ์๊ฒฌ์ ๋ฌด์์
๋๊น? | Pick bodies | {
"A": "์ฝ๋ฌผ ๋จ์ฉ",
"B": "๋ฃจ์ด ์์ฒด",
"C": "ํฝ ์์ฒด",
"D": "์๋ฐ๋ก์ด๋ ํ๋ผํฌ"
} | step1 | C | [
"65 year old man",
"picked",
"security personnel",
"voiding urine",
"inappropriate place",
"community",
"questioning",
"making",
"remarks",
"physical examination",
"physician observed",
"ataxic gait",
"amnesia",
"Initial urine drug screen",
"negative",
"drugs of abuse",
"most likely pathological finding present",
"patient"
] | 00000000000000000286 |
52์ธ ๋จ์ฑ์ด ์ด๋์ผ๋ก ์
ํ๋๊ณ ํด์์ผ๋ก ์ํ๋๋ 1์ฃผ๊ฐ์ ํ๊ณจํ ์๋ฐ์ฑ ํํต ๋ณ๋ ฅ์ผ๋ก ์ด๋ ๋ถํ ๊ฒ์ฌ๋ฅผ ๋ฐ์ต๋๋ค. ๊ฒ์ฌ ์ค ๊ทผ์ก ์ธํฌ ๋ด ๊ธ๋ฆฌ์ฝ๊ฒ ๋ถํด์ ์๋นํ ์ฆ๊ฐ๊ฐ ๊ด์ฐฐ๋ฉ๋๋ค. ๋ค์ ์ค ์ด๋ค ๋ณํ๊ฐ ์ด๋ฌํ ์ธํฌ ๋ด ์๊ฒฌ์ ๊ฐ์ฅ ์ ์ค๋ช
ํฉ๋๊น? | Activation of phosphorylase kinase | {
"A": "Protein kinase A์ ๊ฐ์",
"B": "Phosphorylase kinase์ ํ์ฑํ",
"C": "Glucose-6-phosphate์ ์ฆ๊ฐ",
"D": "Glycogen synthase kinase์ ๋นํ์ฑํ"
} | step1 | B | [
"year old man",
"exercise stress test",
"1-week history of",
"chest pain",
"aggravated by exercise",
"relieved by rest",
"test",
"increase",
"breakdown",
"glycogen",
"muscle cells",
"following changes best",
"intracellular finding"
] | 00000000000000000287 |
35์ธ ๋จ์ฑ์ด 2์ผ ๋์ ์ง์๋ ํผ๋ถ ๋ฐ์ง์ผ๋ก ์ผ๋ฐ ์์ฌ์๊ฒ ๋ด์ํ์ต๋๋ค. ๋ฐ์ง์ ๊ฐ์๊ธฐ ๋ํ๋ฌ๊ณ ์ ์ง์ ์ผ๋ก ์
ํ๋์์ต๋๋ค. ๊ทธ๊ฒ์ ๊ทธ์ ์๋ฑ๊ณผ ์ฝ ์์ ํ๋ฐ์ฑ ๋ณ๋ณ์ผ๋ก ์์๋์์ต๋๋ค. ๊ทธ์ ์์ ์๋ ๋ณ๋ณ์ ์ํฌ์ฑ์ด๊ณ ๊ธด์ฅ๋์์ต๋๋ค. ๊ทธ๋ ์ด์ ์ ์ ์ฌํ ์ฆ์์ ๊ฒฝํํ ์ ์ด ์์ต๋๋ค. ๊ทธ๋ ๋งค์ฐ ๋ฅ๊ณ ํ์ฐฝํ ์ฃผ๋ง ๋์ ์นด๋ ์ฌํ์์ ๋ฐฉ๊ธ ๋์์์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ๋ชฉ๋๋ฏธ์ ์ฝ ๋ค๋ฆฌ์ ํ๋ฐ์ฑ ์ํฌ์ฑ ๋ณ๋ณ์ด ์๊ณ ์์ชฝ ์๋ฑ์ ๊ธด์ฅ์ฑ ๋ฌผ์ง์ด ์๋ ๊ฒ์ด ์ค์ํฉ๋๋ค. ๋ด๋น ์์ฌ๋ ํด ํฉ์ฑ์ ๊ฒฐํจ์ ์์ฌํ๊ณ ๋ช ๊ฐ์ง ํ์ก ๊ฒ์ฌ๋ฅผ ์ง์ํฉ๋๋ค. ๋ค์ ์ ๊ตฌ์ฒด ์ค ์ด๋ ๊ฒ์ด ์ด ํ์์์ ๊ฐ์ฅ ๋์ ๊ฐ๋ฅ์ฑ์ด ์์ต๋๊น? | Uroporphyrinogen III | {
"A": "Uroporphyrinogen III",
"B": "Hydroxymethylbilane",
"C": "Porphobilinogen",
"D": "ฮด-Aminolevulinic acid"
} | step1 | A | [
"35 year old man presents",
"general practitioner",
"skin rash",
"present",
"2 days",
"rash appeared",
"gotten worse",
"started",
"erythematous",
"back of",
"hands",
"nose",
"lesions",
"hands",
"bullous",
"tense",
"never experienced similar symptoms",
"got back",
"canoeing trip",
"very hot",
"sunny weekend",
"Physical exam",
"significant",
"erythematous",
"vesicular lesions",
"nape",
"neck",
"bridge of",
"nose",
"tense bullae",
"dorsum of",
"hands",
"attending physician suspects",
"defect",
"synthesis",
"heme",
"orders",
"blood tests",
"following precursors",
"most likely",
"elevated",
"patient"
] | 00000000000000000288 |
32์ธ ์ฌ์ฑ, ์์ 2ํ, ์ถ์ฐ 1ํ, ์์ 38์ฃผ์ ์ง๋ 1์๊ฐ ๋์์ ์ง ์ถํ๋ก ์ธํด ์๊ธ์ค์ ๋ด์ํ์ต๋๋ค. ํ์๋ ์ถํ์ด ์์๋๊ธฐ ์ ์ ์์ถ๊ฐ์ ๋๊ผ์ง๋ง, ์ถํ์ด ์์๋ ํ ์์ถ์ด ๋ฉ์ท๋ค๊ณ ๋ณด๊ณ ํฉ๋๋ค. ๊ทธ๋
๋ ๋ํ ์ฌํ ๋ณตํต์ ํธ์ํฉ๋๋ค. ๊ทธ๋
์ ์ฒซ ์์ด๋ ํ์ ์ฌ๋ฐ์ ๋ถ์์ ์ผ๋ก ์ธํด ํ๋ถ ์๊ถ์ ๊ฐ ํก๋จ ์ ์์ ๊ฐ๋ก ๋ถ๋งํ์ต๋๋ค. ๋งฅ๋ฐ์ 110ํ/๋ถ, ํธํก์๋ 17ํ/๋ถ, ํ์์ 90/60 mm Hg์
๋๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ ๋ฐ๋ํต์ด๋ ๊ฐ์ง์ด ์๋ ๋ฏธ๋ง์ฑ ๋ณต๋ถ ์ํต์ด ๋ํ๋๊ณ ์์ถ์ ๋๊ปด์ง์ง ์์ต๋๋ค. ํ์ ์ฌ๋ฐ์๋ ์ฌ๋ฐ์ฑ ๋ณ๋์ฑ ๊ฐ์์ ๋ณด์
๋๋ค. ๋ค์ ์ค ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ง๋จ์ ๋ฌด์์
๋๊น? | Uterine rupture | {
"A": "Abruptio placentae",
"B": "Vasa previa",
"C": "Uterine rupture",
"D": "Uterine inertia"
} | step2&3 | C | [
"year old woman",
"gravida 2",
"para 1",
"weeks",
"gestation",
"emergency department",
"of vaginal bleeding",
"past hour",
"patient reports",
"felt contractions prior to",
"onset of",
"bleeding",
"contractions stopped",
"bleeding started",
"severe abdominal",
"first child",
"delivered",
"lower segment transverse cesarean",
"fetal heart rate",
"pulse",
"min",
"respirations",
"min",
"blood pressure",
"90 60 mm Hg",
"Examination shows diffuse abdominal tenderness",
"rebound",
"guarding",
"contractions",
"felt",
"fetal heart rate shows recurrent variable decelerations",
"following",
"most likely diagnosis"
] | 00000000000000000289 |
5์ธ ๋จ์๊ฐ ํธํก ๊ณค๋์ผ๋ก ๋ถ๋ชจ์ ์ํด ์๊ธ์ค๋ก ์ด์ก๋์์ต๋๋ค. ๊ทธ๋ ๋ ์์์ ๋๊ณ ์์๊ณ , ์ ์ง์ ์ธ ์ฒ๋ช
์๊ณผ ํ๋ก๊ฑฐ๋ฆผ์ด ์์๋์์ต๋๋ค. ๊ทธ์ ๋ณ๋ ฅ์ ์ต์ง๊ณผ ๊ฒฌ๊ณผ๋ฅ ์๋ ๋ฅด๊ธฐ๋ก ํน์ง์ง์ด์ง๋๋ค. ํ์๋ ํธํก์ 22ํ/๋ถ์ด๋ฉฐ, ํ
์ด๋ธ์ ์์ ๋ค๋ฆฌ์ ์์ ์น๊ณ ์์ผ๋ก ๊ธฐ์ธ์ด์ ธ ์์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ํก๊ธฐ ๋ฐ ํธ๊ธฐ ์ฒ๋ช
์์ด ๋ํ๋ฌ์ต๋๋ค. ๋ค๋ทธ๋ผ์ด์ ์ฝ๋ฌผ์ด ์์๋์๊ณ , ํธํก ๊ณค๋์ด ์ํ๋๊ธฐ ์์ํ์ต๋๋ค. ๋ค์ ์ค ์ด ํ์์์ ์ด ์ฝ๋ฌผ์ ๊ฒฐ๊ณผ๋ก ์ฆ๊ฐํ๋ ๊ฒ์ ๋ฌด์์
๋๊น? | Cyclic AMP | {
"A": "Cyclic GMP",
"B": "Cyclic AMP",
"C": "Protein kinase C",
"D": "ATP"
} | step1 | B | [
"5 year old boy",
"brought",
"emergency department",
"parents",
"difficulty breathing",
"playing outside",
"snow",
"progressive onset",
"wheezing",
"gasping",
"history",
"notable",
"eczema",
"nut allergies",
"patient",
"respirations",
"min",
"forward",
"hands",
"legs",
"seated",
"table",
"Physical",
"notable",
"inspiratory",
"expiratory wheezes",
"exam",
"nebulized medication",
"started",
"begins to relieve",
"breathing difficulties",
"following",
"increased",
"patient",
"result",
"medication"
] | 00000000000000000290 |
๊ณผ๊ฑฐ๋ ฅ์ ๊ด์ ๋๋งฅ ์งํ์ด ์๊ณ , ํ์ฌ aspirin๊ณผ clopidogrel์ ๋ณต์ฉ ์ค์ธ ๊ด์ ๋๋งฅ ์คํ
ํธ ์ฝ์
์ ํ ์ํ์ 78์ธ ๋จ์ฑ์ด ๊ทธ์ ์๋ด์ ์ํด ์์ค์์ ์ฐ๋ฌ์ง ์ฑ ๋ฐ๊ฒฌ๋์์ต๋๋ค. ๊ทธ์ GCS ์ ์๋ 3์ ์ด์๊ณ ์ ํํ ์ ์ฒด ๊ฒ์ฌ๋ ์ ํ์ ์
๋๋ค. ์๊ธ์ผ๋ก ์ํํ ๋น์กฐ์ CT ๋ ์ค์บ์์ ์ฃผ๋ณ ๋ถ์ข
์ ๋๋ฐํ ๊ด๋ฒ์ํ ์ฐ์ธก ๋์ ์ฝ ๋๊ฐ๋ด ์ถํ์ด ๋ํ๋ฌ์ต๋๋ค. ๊ทธ๋ ์ฆ์ ๋ชจ๋ํฐ๋ง์ ์ํด ์คํ์์ค(ICU)๋ก ์ด์ก๋์์ต๋๋ค. ๋ค์๋ ๊ทธ์ ์ ์ ์ํ๋ ๊ณ์ ์
ํ๋์์ง๋ง ๋ฐ๋ณต CT ์ค์บ์์๋ ์๋ก์ด ์ถํ์ด ๋ณด์ด์ง ์์์ต๋๋ค. ๋ํ ํ์์ ์๋ณ๋์ ์ง๋ ๋ช ์๊ฐ ๋์ >200 cc/hr๋ก ์ฆ๊ฐํ์ต๋๋ค. ๊ทธ์ ์ฒด์จ์ 99.0 deg F (37.2 deg C), ํ์์ 125/72 mmHg, ๋งฅ๋ฐ์ 87/min, ํธํก์๋ 13/min์
๋๋ค. ๋ค์ ์ค ํ์์ ์๋ณ ๋น์ค, ์๋ณ ์ผํฌ์, ํ์ฅ ์ผํฌ์ ๋ฐ ํ์ฒญ ๋ํธ๋ฅจ์ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ๊ฐ์ ๋ฌด์์
๋๊น? | Low, Low, High, High | {
"A": "Low, High, High, High",
"B": "Low, Low, High, Low",
"C": "Low, Low, High, High",
"D": "High, Low, Low, High"
} | step2&3 | C | [
"year",
"male",
"history of coronary artery disease",
"status coronary currently",
"aspirin",
"clopidogrel",
"found",
"bathroom",
"wife",
"GCS score",
"3",
"accurate physical exam",
"limited",
"stat non contrast CT scan of",
"brain",
"large right parietal intracranial",
"surrounding edema",
"transferred",
"intensive care unit",
"monitoring",
"next day",
"mental status continues to worsen",
"repeat CT scan shows",
"new bleeding",
"addition",
"patients urinary output",
"200 cc",
"hours",
"increasing",
"temperature",
"99 0 deg F",
"37 2",
"blood pressure",
"72 mmHg",
"pulse",
"87 min",
"respirations",
"min",
"following values",
"most likely",
"patients urine specific gravity",
"urine osmolality",
"plasma osmolality",
"serum sodium"
] | 00000000000000000291 |
53์ธ ์ฌ์ฑ์ด ์ถ์ ๊ฒ์ฌ๋ฅผ ์ํด ์์ฌ๋ฅผ ์ฐพ์์์ต๋๋ค. ํ ๋ฌ ์ , ๊ทธ๋
๋ ์ผ์ชฝ ์ ๋ฐฉ์ ์ง๋จ์ ๋ฐ์์ต๋๋ค. ๊ทธ๋
๋ 2์ฃผ ์ ์ 2.1cm ์ข
๊ดด์ ๋ํ ์ ๋ฐฉ ์ข
๊ดด ์ ์ ์ ๊ณผ ๊ฐ์ ๋ฆผํ์ ์๊ฒ์ ๋ฐ์์ต๋๋ค. ์ ๋ฐฉ ์ข
๊ดด ์๊ฒ ๊ฒฐ๊ณผ, ์นจ์ค์ฑ ๊ด์ํผ์์ข
์ผ๋ก ํ๋ช
๋์์ผ๋ฉฐ, ์ ์ ๋ฉด์ ๊นจ๋ํ์ต๋๋ค. ๋ฉด์ญ ์กฐ์ง ํํ ๊ฒ์ฌ ๊ฒฐ๊ณผ, ์์ข
์ estrogen-receptor ๋ฐ progesterone-receptor ์์ฑ, ๊ทธ๋ฆฌ๊ณ HER2-receptor ์์ฑ์ผ๋ก ๋ํ๋ฌ์ต๋๋ค. ๋ฆผํ์ ์๊ฒ์์๋ ์ ์ด๊ฐ ๋ฐ๊ฒฌ๋์ง ์์์ต๋๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ, ์ผ์ชฝ ์ ๋ฐฉ์ ์์ ์ ๊ฐ ๋ถ์๊ฐ ์น์ ๋๊ณ ์๋ ๊ฒ์ผ๋ก ๋ํ๋ฌ์ต๋๋ค. ์ด์ง ๊ฐ๋ฅํ ์ก์ ๋ฆผํ์ ๋ณ์ฆ์ ์์ต๋๋ค. ๊ทธ๋
์ ๋ด๋น ์์ฌ๋ ์ ์ ํ ์ฝ๋ฌผ ์๋ฒ์ผ๋ก ์น๋ฃ๋ฅผ ์์ํ๊ธฐ๋ก ๊ฒฐ์ ํฉ๋๋ค. ๋ค์ ์ค ๊ด๋ฆฌ์ ์์ด ๊ฐ์ฅ ์ ์ ํ ๋ค์ ๋จ๊ณ๋ ๋ฌด์์
๋๊น? | Echocardiography | {
"A": "Echocardiography",
"B": "Fundoscopy",
"C": "X-ray of the chest",
"D": "Endometrial biopsy"
} | step2&3 | A | [
"year old woman",
"physician",
"follow-up examination",
"One month",
"diagnosed",
"carcinoma of the left breast",
"lumpectomy",
"mass",
"sentinel lymph node biopsy",
"weeks",
"biopsy of",
"breast mass showed margin free invasive ductal carcinoma",
"immunohistochemistry showed",
"carcinoma",
"estrogen-receptor",
"progesterone-receptor negative",
"HER2 receptor positive",
"lymph node biopsy",
"negative",
"metastases",
"Examination shows",
"healing",
"left",
"palpable axillary lymphadenopathy",
"physician",
"to initiate treatment",
"appropriate pharmacotherapy",
"following",
"most appropriate next step",
"management"
] | 00000000000000000292 |
์ถ์ ํ 3์ฃผ ๋ ์ฌ์๊ฐ ๋ฌดํธํก ์ฆ์์ ๋ณด์
๋๋ค. ์ง๋ ์ดํ ๋์ ์ ์ ๋ ๋ฌด๊ธฐ๋ ฅํด์ก์ผ๋ฉฐ, ์ง๋ ํ๋ฃจ ๋์ ๊ฐ๊ฐ 10์ด์ฉ ์ง์๋๋ ๋ฌดํธํก ์ฆ์์ ๋ ๋ฒ ๊ฒช์์ต๋๋ค. ๊ทธ๋
๋ ์์ 31์ฃผ์ ํ์ด๋ฌ๊ณ ์ฒด์ค์ 1600-g (3-lb 8-oz)์ด์์ต๋๋ค. Apgar ์ ์๋ 1๋ถ๊ณผ 5๋ถ์ ๊ฐ๊ฐ 4์ ๊ณผ 7์ ์ด์์ต๋๋ค. ๊ทธ๋
๋ ์ฝ๋ฌผ์ ๋ณต์ฉํ์ง ์์ต๋๋ค. ์ฒด์จ์ 36.7ยฐC (98.0ยฐF), ๋งฅ๋ฐ์ 185/๋ถ, ํธํก์ 60/๋ถ์ผ๋ก ๋ถ๊ท์นํ๋ฉฐ ํ์์ 70/35 mm Hg์
๋๋ค. ๊ทธ๋
๋ ์ฐฝ๋ฐฑํด ๋ณด์
๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์๋ ์ด์์ด ๋ฐ๊ฒฌ๋์ง ์์์ต๋๋ค. ์คํ์ค ๊ฒ์ฌ ๊ฒฐ๊ณผ ํค๋ชจ๊ธ๋ก๋น์ 6.5 g/dL, ๋ง์ ์ ํ๊ตฌ ์๋ 0.5%, ํ๊ท ์ ํ๊ตฌ ์ฉ์ ์ 92 ฮผm3์
๋๋ค. ๋ฐฑํ๊ตฌ ์, ํ์ํ ์, ์ด ๋น๋ฆฌ๋ฃจ๋น ๋ฐ ๊ฐ์ ๋น๋ฆฌ๋ฃจ๋น์ ๋ชจ๋ ์ฐธ๊ณ ๋ฒ์ ๋ด์ ์์ต๋๋ค. ๋ค์ ์ค ์ด ํ์์ ๋นํ์ ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ ์๋ ๊ธฐ์ ๋ฉ์ปค๋์ฆ์ ๋ฌด์์
๋๊น? | Impaired erythropoietin production | {
"A": "Defective ฮด-aminolevulinic acid synthase",
"B": "Bone marrow suppression",
"C": "Glucose-6-phosphate dehydrogenase deficiency",
"D": "Impaired erythropoietin production"
} | step2&3 | D | [
"Three weeks after birth",
"infant girl",
"episodes of apnea",
"lethargic",
"past two days",
"two episodes of apnea lasting 10 seconds",
"last day",
"born",
"31 weeks of gestation",
"1600 g",
"8 oz",
"Apgar scores",
"5 minutes",
"takes",
"medications",
"temperature",
"36",
"98",
"pulse",
"min",
"respirations",
"60 min",
"irregular",
"blood pressure",
"70 35 mm Hg",
"appears pale",
"Physical examination shows",
"abnormalities",
"Laboratory studies show a hemoglobin",
"g/dL",
"reticulocyte count",
"0.5",
"mean corpuscular volume",
"m3",
"Leukocyte",
"platelet count",
"total bilirubin",
"indirect bilirubin",
"reference range",
"following",
"most likely underlying mechanism",
"patient's anemia"
] | 00000000000000000293 |
45์ธ ์ฌ์ฑ ํ์๊ฐ 6๊ฐ์๊ฐ ์งํ๋๋ ํธํก ๊ณค๋ ์ฆ์์ผ๋ก ์์ฌ๋ฅผ ์ฐพ์์ต๋๋ค. ํ์ฌ ๊ทธ๋
๋ 3์ธต ์ํํธ ๊ณ๋จ์ ์ค๋ฅผ ๋๋ง๋ค ์ธ๋ค ๋ฒ ์ฌ์ด์ผ ํฉ๋๋ค. ๊ทธ๋
๋ ๋ง์ฑ์ ์ด๊ณ ๋น์์ฐ์ ์ธ ๊ธฐ์นจ๊ณผ ์ฒ๋ช
์ ํธ์ํ๋ฉฐ, ์ด๋ฅผ ์ํด ipratropium ํก์
๊ธฐ๋ฅผ ์ฌ์ฉํ๊ณ ์์ต๋๋ค. ๊ทธ๋
๋ 25 pack-year์ ํก์ฐ ์ด๋ ฅ์ด ์์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ํ์์ 130/80 mm Hg, ๋งฅ๋ฐ์๋ 95/min, ์ฒด์จ์ 36.6ยฐC (97.8ยฐF), ํธํก์๋ 26/min์
๋๋ค. ํ๋ถ ์ฒญ์ง์์ ์์ธก์ฑ ์ํฌ์์ด ๋ํ๋ฉ๋๋ค. ์ฌ์ฅ ์ฒญ์ง์์๋ ์ก์์ด๋ ๋ถ๊ฐ์ ์์ด ์ ์์ ์ธ S1๊ณผ S2๊ฐ ๋ํ๋ฉ๋๋ค. ๋๋งฅํ ๊ฐ์ค ๋ถ์ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค.
pH 7.36 (์ฐธ๊ณ ์น: 7.35-7.45)
HCO3- 32 mEq/L (์ฐธ๊ณ ์น 22-28 mEq/L)
Pco2 48 mm Hg (์ฐธ๊ณ ์น: 33-45 mm Hg)
Po2 63 mm Hg (์ฐธ๊ณ ์น: 75-105 mm Hg)
O2 saturation 91% (์ฐธ๊ณ ์น: 94-99%)
์ด ํ์์๊ฒ์ ๋ค์ ์ค ๋ฌด์์ ๊ธฐ๋ํ ์ ์์ต๋๊น? | Decreased diffusing capacity of the lungs for carbon monoxide (DLCO) | {
"A": "ํ ์๊ธฐ๋ ๊ฐ์",
"B": "์ผ์ฐํํ์(DLCO)์ ๋ํ ํ ํ์ฐ ๋ฅ๋ ฅ ๊ฐ์",
"C": "์ ๋ ์ฉ์ ๊ณก์ ์ ์ค๋ฅธ์ชฝ ์ด๋",
"D": "ํ ํ์ฑ ๊ฐ์"
} | step1 | B | [
"year old woman presents",
"physician",
"month history of progressive shortness",
"breath",
"now",
"to stop to rest three",
"four times",
"climbs",
"stairs",
"apartment",
"third floor",
"reports chronic",
"nonproductive cough",
"wheezing",
"uses ipratropium inhalers",
"pack-year smoking history",
"examination",
"blood pressure",
"80 mm Hg",
"pulse rate",
"95 min",
"temperature",
"36",
"97",
"respiratory rate",
"min",
"Chest auscultation reveals bilateral crepitations",
"Cardiac auscultation reveals normal S1",
"S2",
"murmurs",
"added sounds",
"Arterial blood gas analysis shows",
"pH 7 36",
"reference",
"HCO3",
"mEq/L",
"reference",
"mEq/L",
"Pco2 48 mm Hg",
"reference",
"mm Hg",
"Po2 63 mm Hg",
"reference",
"mm Hg",
"O2 saturation",
"reference",
"following",
"to find",
"patient"
] | 00000000000000000294 |
27์ธ ๋จ์ฑ์ด ์ ์ ๋ ๋ฉ์ด์ง๋ ๊ฒ์ ๋ํด ์ฐ๋ คํ๋ ๊ทธ์ ์ด๋จธ๋์ ์ํด ์ ์ ๊ณผ ์์ฌ์๊ฒ ๋ฐ๋ ค์์ก์ต๋๋ค. ์ง๋ฌธ์ ๋ฐ์์ ๋, ๊ทธ๋ ํผ์ ๋ฐ์ ๋๊ฐ๋ ๊ฒ์ด ๋๋ ค์์ ๋ ์ด์ ์ธ์ถํ์ง ์๋๋ค๊ณ ๋งํฉ๋๋ค. ๊ทธ๋ ์ญ ๋ ๋๋ถํฐ ๋ง์ ๊ตฐ์ค๊ณผ ๋์ค ๊ตํต์ ์ด์ฉํ๋ ๊ฒ์ด ๋ถํธํ๋ค๊ณ ๋งํฉ๋๋ค. ๊ทธ๋ ํ์ฌ ์ฌํ๊ทผ๋ฌด๋ฅผ ํ๊ณ ์์ผ๋ฉฐ ์๋ฌด์ ์ธ ์
๋ฌด ์ธ์๋ ๊ฑฐ์ ์ง์ ๋ ๋์ง ์์ต๋๋ค. ๋ค์ ์ค ์ด๋ค ์ฑ๊ฒฉ ์ฅ์ ๊ฐ ์ด ํ์์ ์ฅ์ ์ ์ ์ ์ ์ผ๋ก ๊ฐ์ฅ ๊ด๋ จ์ด ์์ ๊ฐ๋ฅ์ฑ์ด ๋์ต๋๊น? | Dependent | {
"A": "Antisocial",
"B": "Dependent",
"C": "Histrionic",
"D": "Schizotypal"
} | step1 | B | [
"27 year old man",
"brought",
"psychiatrist",
"mother",
"concerned",
"distant",
"longer",
"out",
"afraid",
"outside",
"ever",
"teenager",
"large crowds",
"public transportation",
"now works",
"home",
"rarely leaves",
"house",
"mandatory business",
"following personality disorders",
"most likely",
"associated with",
"patient's disorder"
] | 00000000000000000295 |
26์ธ ์ฌ์ฑ์ด ๊ฐ์์ค๋ฌ์ด ํ๋ถ ์ํต์ ํธ์ํ๋ฉฐ ๋ด์ํ์ต๋๋ค. ๊ทธ๋
๋ ๋ช ์๊ฐ ์ ์ฒด์ก๊ด์์ ์ด๋ํ๋ ์ค ๋ ์นด๋ก์ด ํต์ฆ์ ๋๊ผ๋ค๊ณ ๋งํฉ๋๋ค. ํต์ฆ์ ๋ค๋ฆฌ ์๋ฉด์ ๋ฐ๋ผ ๋ฐ๊น์ง ๋ฐฉ์ฌ๋ฉ๋๋ค. ์ ์ฒด ๊ฒ์ฌ์์ ๊ทธ๋
์ ํ๋ ฅ ์งํ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค. HR 95, BP 120/70, T 37.2๋ C. ํ์ง ์ง๊ฑฐ์ ๊ฒ์ฌ์์ ๋ค๋ฆฌ ์๋๋ก ๊ทน์ฌํ ํต์ฆ์ด ์์ต๋๋ค. ๊ฐ๋ฒผ์ด ์ ์ด๊ณผ ํ์ผ๋ก ์ฐ๋ฅด๋ ์๊ทน์ ๋ํ ๊ฐ๊ฐ์ ์ ๋ฐ์ ์ผ๋ก ์ ์์
๋๋ค. ๋ค์ ์ค ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ง๋จ์ ๋ฌด์์
๋๊น? | Disc herniation | {
"A": "Disc herniation",
"B": "Osteomyelitis",
"C": "Spinal stenosis",
"D": "Ankylosing spondylitis"
} | step2&3 | A | [
"year old woman presents",
"sudden-onset pain",
"lower back",
"exercising",
"hours",
"felt",
"sharp pain",
"pain",
"radiating",
"side",
"leg",
"foot",
"physical exam",
"vital signs",
"follows",
"95",
"BP",
"70",
"T",
"degrees C",
"extreme pain",
"leg",
"straight leg raise",
"sensation",
"light touch",
"pin prick",
"intact",
"following",
"most likely diagnosis"
] | 00000000000000000296 |
AIDS๋ฅผ ์๊ณ ์๋ 34์ธ ๋จ์ฑ์ด ์๋ ฅ ์ ํ์ ์ค๋ฅธ์ชฝ ๋์ ๊ฒ์ ์ ์ด ๋ณด์ด๋ 2์ผ์ ๋ณ๋ ฅ์ ์ด์ ๋ก ์์ฌ๋ฅผ ์ฐพ์์ต๋๋ค. ํต์ฆ์ ์์ผ๋ฉฐ ์ผ์ชฝ ๋์ ๋ฌด์ฆ์์
๋๋ค. 6๊ฐ์ ์ ํ๋ฃจ์ฝ๋์กธ๋ก ์ง๊ท ์ฑ ์๋์ผ ์น๋ฃ๋ฅผ ๋ฐ์์ต๋๋ค. 2๋
์ ์นดํฌ์ ์ก์ข
์ง๋จ์ ๋ฐ์์ต๋๋ค. ํ์ฌ ๋ณต์ฉ ์ค์ธ ์ฝ๋ฌผ์ ์ํ๋น๋ ์ธ , ํ
๋
ธํฌ๋น์ด, ์ ํธ๋ฆฌ์ํ๋น, ์์งํธ๋ก๋ง์ด์ , ํธ๋ฆฌ๋ฉํ ํ๋ฆผ-์คํ๋ฉํก์ฌ์กธ, ์ข
ํฉ ๋นํ๋ฏผ, ์์ ๋ณด์ถฉ์ ์
๋๋ค. ํค๋ 170cm(5ํผํธ 7์ธ์น)์ด๊ณ ๋ชธ๋ฌด๊ฒ๋ 45kg(99ํ์ด๋)์ด๋ฉฐ, BMI๋ 15.6kg/m2์
๋๋ค. ์ฒด์จ์ 37ยฐC(98.6ยฐF), ๋งฅ๋ฐ์ ๋ถ๋น 89ํ, ํ์์ 110/70mmHg์
๋๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ ๊ฒฝ๋ถ ๋ฆผํ์ ๋ณ์ฆ์ด ๋ํ๋ฌ์ต๋๋ค. ๋ชธํต๊ณผ ์ฌ์ง์ ์ฌ๋ฌ ๊ฐ์ ๋ณด๋ผ์ ๋ฐ์ ์ด ๊ด์ฐฐ๋ฉ๋๋ค. ์์ ๊ฒ์ฌ ๊ฒฐ๊ณผ ๋ง๋ง ํ๊ด ์ฃผ๋ณ์ ๊ณผ๋ฆฝ์ ํฉ๋ฐฑ์ ํผํ๊ณผ ์ฌ๋ฌ ๋ถ์์ ์ ์ ์ถํ์ด ๋ํ๋ฌ์ต๋๋ค. CD4+ T ๋ฆผํ๊ตฌ ์๋ 36/mm3์
๋๋ค. ๋ค์ ์ค ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ง๋จ์ ๋ฌด์์
๋๊น? | Cytomegalovirus retinitis | {
"A": "๊ฑฐ๋์ธํฌ๋ฐ์ด๋ฌ์ค ๋ง๋ง์ผ",
"B": "ํก์ํ๋ผ์ค๋ง ๋ง๋ง์ผ",
"C": "HIV ๋ง๋ง๋ณ์ฆ",
"D": "์๋ ๋์ ํฌ์ง ๋ง๋ง์ผ"
} | step2&3 | A | [
"year old man",
"AIDS",
"physician",
"2-day history",
"decreasing vision",
"seeing black spots",
"right eye",
"pain",
"left eye",
"asymptomatic",
"treated",
"fungal esophagitis",
"months",
"fluconazole",
"diagnosed",
"Kaposi's sarcoma 2 years",
"Current medications include efavirenz",
"tenofovir",
"emtricitabine",
"azithromycin",
"trimethoprim-sulfamethoxazole",
"multivitamins",
"nutritional supplement",
"5 ft",
"tall",
"kg",
"99 lbs",
"BMI",
"kg/m2",
"temperature",
"98",
"pulse",
"min",
"blood pressure",
"70 mm Hg",
"Examination shows cervical lymphadenopathy",
"multiple violaceous plaques seen",
"trunk",
"extremities",
"Fundoscopic examination shows granular yellow white opacities",
"retinal vessels",
"multiple areas",
"dot-blot hemorrhages",
"CD4",
"lymphocyte count",
"36 mm3",
"following",
"most likely diagnosis"
] | 00000000000000000297 |
45์ธ ๋จ์ฑ์ด ๋ฌดํต์ฑ ๋ชฉ ๋ฉ์ด๋ฆฌ์ 2๊ฐ์๊ฐ์ ์ฐํ๊ณค๋์ ํธ์ํ๋ฉฐ ์์ฌ๋ฅผ ์ฐพ์์ต๋๋ค. ๊ทธ๋ ์ฌ๋ฐ์ฑ nephrolithiasis ๋ฐ ๊ฐํ์ hypertension ๋ณ๋ ฅ์ด ์์ต๋๋ค. ์ ์ฒด ๊ฒ์ฌ ๊ฒฐ๊ณผ ๊ฐ์ ์ฐ๊ณจ ๋์ด์์ 3 ร 3cm ํฌ๊ธฐ์ ์ํต์ด ์๋ ๊ฒฐ์ ์ด ๊ด์ฐฐ๋์์ต๋๋ค. ๊ฒฐ์ ์ ์ค์ฌ๋ถ ๋ฐ๋ ์๊ฒ์ผ๋ก ์ป์ ์กฐ์ง ๋จ๋ฉด์ ํ๋ฏธ๊ฒฝ ์ฌ์ง์ด ์ ์๋์ด ์์ต๋๋ค. ๋ค์ ์ค ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ง๋จ์ ๋ฌด์์
๋๊น? | Medullary carcinoma | {
"A": "Follicular carcinoma",
"B": "Non-Hodgkin lymphoma",
"C": "Papillary carcinoma",
"D": "Medullary carcinoma"
} | step1 | D | [
"year old man",
"physician",
"painless neck lump",
"2 month history",
"difficulty swallowing",
"history of recurrent nephrolithiasis",
"episodic hypertension",
"Physical examination shows",
"3",
"3",
"nontender nodule",
"the level of",
"thyroid cartilage",
"photomicrograph",
"section",
"tissue obtained",
"core needle biopsy",
"nodule",
"shown",
"following",
"most likely diagnosis"
] | 00000000000000000298 |
17์ธ ์๋
์ด 12์ผ ๋์ ์ฐ์ธก ๋ฌด๋ฆ์ ํต์ฆ๊ณผ ๋ถ์ข
์ด ์ฆ๊ฐํ์ฌ ์์ฌ์๊ฒ ์ง์ฐฐ์ ๋ฐ์๋ค. ๊ทธ๋ 3์ฃผ ๋์ ๋ฐฐ๋จ ์ ํต์ฆ์ ๊ฒช์๋ค. ๊ทธ๋ ์ผ์ฃผ์ผ ์ ์น๋ฃ ์์ด ํธ์ ๋, ํต์ฆ์ด ์๊ณ ๋ถ์ด ์๋ ์ข์ธก ๋ฐ๋ชฉ ๊ด์ ์ ๊ฒช์๋ค. ๊ทธ์ ์ด๋จธ๋๋ ๋ฅ๋งํฐ์ค ๊ด์ ์ผ์ ์๊ณ ์๋ค. ๊ทธ๋ ๋ ๋ช
์ ์ฌ์ฑ ํํธ๋์ ์ฑ๊ด๊ณ๋ฅผ ๊ฐ์ง๋ฉฐ, ์ฝ๋์ ๋ถ๊ท์น์ ์ผ๋ก ์ฌ์ฉํ๋ค. ๊ทธ๋ ๋ถ์ํด ๋ณด์ธ๋ค. ๊ทธ์ ์ฒด์จ์ 38ยฐC (100.4ยฐF), ๋งฅ๋ฐ์ 68ํ/๋ถ, ํ์์ 100/80 mm Hg์ด๋ค. ๊ฒ์ฌ ๊ฒฐ๊ณผ ์์ธก ๊ฒฐ๋ง์ ์ผ์ฆ์ด ๋ํ๋๋ค. ์ฐ์ธก ๋ฌด๋ฆ์ ์ํต, ๋ฐ์ , ๋ถ์ข
์ด ์์ผ๋ฉฐ, ํต์ฆ์ผ๋ก ์ธํด ์ด๋ ๋ฒ์๊ฐ ์ ํ๋๋ค. ์ข์ธก ์ํฌ๋ ์ค ๊ฑด ์ฝ์
๋ถ์์ ์ํต์ด ์๋ค. ์์๊ธฐ ๊ฒ์ฌ์์๋ ์ด์์ด ๋ํ๋์ง ์๋๋ค. ์คํ์ค ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ๋ค์๊ณผ ๊ฐ๋ค:
ํ์์ 14.5 g/dL
๋ฐฑํ๊ตฌ ์ 12,300/mm3
ํ์ํ ์ 310,000/mm3
์ ํ๊ตฌ ์นจ๊ฐ ์๋ 38 mm/h
ํ์ฒญ
์์ ์ง์ 18 mg/dL
ํฌ๋๋น 89 mg/dL
ํฌ๋ ์ํฐ๋ 1.0 mg/dL
์๋ณ
๋จ๋ฐฑ์ง ์์ฑ
ํ์ก ์์ฑ
WBC 12-16/hpf
RBC 1-2/hpf
HIV์ ๋ํ ELISA ๊ฒ์ฌ ๊ฒฐ๊ณผ๋ ์์ฑ์ด๋ค. ๊ด์ ์ฒ์์ ์ ์ํํ๋ค. ํ์ก์ ํ๋ฆฌ๊ณ Gram stain ๊ฒฐ๊ณผ๋ ์์ฑ์ด๋ค. ํ์ก ๋ถ์ ๊ฒฐ๊ณผ ๋ฐฑํ๊ตฌ ์๋ 26,000/mm3, ์ค์ฑ๊ตฌ๋ 75%๋ฅผ ๋ํ๋ธ๋ค. ๋ค์ ์ค ๊ฐ์ฅ ๊ฐ๋ฅ์ฑ์ด ๋์ ์ง๋จ์ ๋ฌด์์ธ๊ฐ?" | Reactive arthritis | {
"A": "ํจํ์ฑ ๊ด์ ์ผ",
"B": "๋ผ์ ๊ด์ ์ผ",
"C": "๋ฐ์์ฑ ๊ด์ ์ผ",
"D": "๋งค๋
์ฑ ๊ด์ ์ผ"
} | step2&3 | C | [
"year old boy",
"brought",
"physician",
"increasing pain",
"swelling of",
"right knee",
"days",
"episodes of pain",
"urination",
"weeks",
"painful",
"swollen left ankle joint",
"resolved",
"treatment one week",
"mother",
"rheumatoid arthritis",
"sexually active",
"female partners",
"uses condoms",
"appears anxious",
"temperature",
"100 4F",
"pulse",
"68 min",
"blood pressure",
"100 80 mm Hg",
"Examination shows bilateral inflammation of",
"conjunctiva",
"right knee",
"tender",
"erythematous",
"swollen",
"range of motion",
"limited",
"pain",
"tenderness",
"left Achilles tendon insertion site",
"Genital examination shows",
"abnormalities",
"Laboratory studies show",
"Hemoglobin",
"count",
"mm3 Platelet count",
"rate",
"h Serum",
"Glucose",
"Creatinine",
"Protein negative",
"WBC",
"hpf",
"ELISA test",
"HIV",
"negative",
"Arthrocentesis",
"synovial fluid",
"cloudy",
"Gram stain",
"negative",
"Analysis",
"synovial fluid shows",
"leukocyte count",
"mm3",
"75",
"neutrophils",
"following",
"most likely diagnosis"
] | 00000000000000000299 |
72์ธ ๋จ์ฑ์ด ์ผ๊ฐ ๋ฐฐ๋จ ํ์์ ๋ํด ์ฃผ์น์์ ์์ํ๊ธฐ ์ํด ์ง๋ฃ์ค์ ๋ฐฉ๋ฌธํ์ต๋๋ค. ๊ทธ๋ ๋ฐค์ ์ก์ฒด ์ญ์ทจ๋ฅผ ํผํ์ง๋ง ์ฆ์์ ์ ์ง์ ์ผ๋ก ์
ํ๋์์ต๋๋ค. ๋ณ๋ ฅ์ ๊ณ ํ์ ๋ฐ ๊ณ ์งํ์ฆ์ด ์ ์๋ฏธํฉ๋๋ค. ๊ทธ๋ ๋งค์ผ lisinopril, atorvastatin ๋ฐ ์ข
ํฉ ๋นํ๋ฏผ์ ๋ณต์ฉํฉ๋๋ค. ์ค๋ ํ๋ ฅ ์งํ๋ ๋ค์๊ณผ ๊ฐ์ต๋๋ค: ํ์ 120/80 mm Hg, ์ฌ๋ฐ์ 90/๋ถ, ํธํก์ 17/๋ถ, ์ฒด์จ 37.0ยฐC (98.6ยฐF). ์ ์ฒด ๊ฒ์ฌ์์ ๊ทธ๋ ํผ๊ณคํด ๋ณด์
๋๋ค. ์ฌ์ฅ์ ๊ท์น์ ์ธ ์๋์ ๋ฆฌ๋ฌ์ ๋ณด์ด๋ฉฐ, ํ๋ ์์ธก ์ฒญ์ง ์ ๋ง์ต๋๋ค. ์นจ์ ๋ฐฉ๊ด ์ด์ํ ๊ฒ์ฌ ๊ฒฐ๊ณผ ๋ฐฉ๊ด์ด ๊ฐ๋ ์ฐจ ์์ต๋๋ค. ์ง์ฅ ์์ง ๊ฒ์ฌ ๊ฒฐ๊ณผ ๊ฒฐ์ ์ด ์๋, ๋น๋์นญ ์ ๋ฆฝ์ ๋น๋์ฆ๊ณผ ์ผ์นํ๋ ๋น๋์นญ ์ ๋ฆฝ์ ์ด ๋ํ๋ฌ์ต๋๋ค. ๊ทธ๋ ๋ํ ๊ณผ๊ฑฐ์ ์ฌ๋ฌ ์ฐจ๋ก ์ค์ ์ํผ์๋๊ฐ ์๋ ์ฆ์์ฑ ์ ํ์ ๋ณ๋ ฅ์ด ์์ต๋๋ค. ํ์๋ ํ์ง์ ์ ๊ณตํ ์ ์๋ ์ ๋ฆฝ์ ์๊ฒ์ ๊ฑฐ๋ถํ๊ณ ๋ ์นจ์ต์ ์ธ ์น๋ฃ๋ฅผ ์์ฒญํฉ๋๋ค. ๋ค์ ์ค ์ด ํ์์ ์ ๋ฆฝ์ ๋น๋์ฆ ์น๋ฃ์ ๊ถ์ฅ๋๋ ๊ฒ์ ๋ฌด์์
๋๊น? | Finasteride | {
"A": "Tamsulosin",
"B": "Finasteride",
"C": "Tadalafil",
"D": "Leuprolide"
} | step1 | B | [
"72 year old man presents",
"primary care provider to discuss",
"frequency",
"wakes up",
"night to",
"drinking liquids",
"night",
"symptoms",
"worsened",
"medical history",
"significant",
"hypertension",
"hyperlipidemia",
"takes lisinopril",
"atorvastatin",
"multivitamin",
"day",
"Today",
"vital signs include",
"blood pressure",
"80 mm Hg",
"heart rate 90 min",
"respiratory rate",
"min",
"temperature",
"98",
"physical examination",
"appears tired",
"heart",
"regular rate",
"rhythm",
"lungs",
"clear",
"auscultation",
"bladder ultrasound reveals",
"full bladder",
"digital rectal exam reveals",
"enlarged",
"symmetric prostate free",
"nodules",
"consistent with benign prostatic enlargement",
"history of symptomatic hypotension",
"several episodes of syncope",
"past",
"patient",
"prostate biopsy",
"provide",
"definitive diagnosis",
"requests less invasive treatment",
"following",
"recommended to treat",
"patients enlarged prostate"
] | 00000000000000000300 |
Subsets and Splits