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-4057742626596309727-hardneg-1 | Prolactin | Discovered in non-human animals around 1930 by Oscar Riddle and confirmed in humans in 1970 by Henry Friesen, prolactin is a peptide hormone, encoded by the "PRL" gene. | [
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-4057742626596309727-hardneg-2 | Prolactin | Several variants and forms are known per species. Many fish have variants "prolactin A" and "prolactin B". Most vertebrates, including humans, also have the closely related somatolactin. In humans, three smaller (4, 16, and 23 kDa) and several larger (so-called big and big-big) variants exist. | [
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-4057742626596309727-hardneg-3 | Prolactin | Prolactin has a wide variety of effects. It stimulates the mammary glands to produce milk (lactation): increased serum concentrations of prolactin during pregnancy cause enlargement of the mammary glands and prepare for milk production, which normally starts when levels of progesterone fall by the end of pregnancy and a suckling stimulus is present. Prolactin plays an important role in maternal behavior. | [
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-4057742626596309727-hardneg-4 | Prolactin | It has been shown in rats and sheep that prolactin affects lipid synthesis differentially in mammary and adipose cells. Prolactin deficiency induced by bromocriptine increased lipogenesis and insulin responsiveness in adipocytes while decreasing them in the mammary gland. | [
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-4057742626596309727-hardneg-5 | Prolactin | Elevated levels of prolactin decrease the levels of sex hormones—estrogen in women and testosterone in men. The effects of mildly elevated levels of prolactin are much more variable, in women, substantially increasing or decreasing estrogen levels. | [
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-4057742626596309727-hardneg-6 | Prolactin | Prolactin also stimulates proliferation of oligodendrocyte precursor cells. These cells differentiate into oligodendrocytes, the cells responsible for the formation of myelin coatings on axons in the central nervous system. | [
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-4057742626596309727-hardneg-7 | Prolactin | Other actions include contributing to pulmonary surfactant synthesis of the fetal lungs at the end of the pregnancy and immune tolerance of the fetus by the maternal organism during pregnancy. Prolactin promotes neurogenesis in maternal and fetal brains. | [
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-4057742626596309727-hardneg-8 | Prolactin | Prolactin and its receptor are expressed in the skin, specifically in the hair follicles, where they regulate hair growth and moulting in an autocrine fashion. Elevated levels of prolactin can inhibit hair growth, and knock-out mutations in the prolactin gene cause increased hair length in cattle and mice. Conversely, mutations in the prolactin receptor can cause reduced hair growth, resulting in the "slick" phenotype in cattle. Additionally, prolactin delays hair regrowth in mice. | [
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-4057742626596309727-hardneg-9 | Prolactin | Analogous to its effects on hair growth and shedding in mammals, prolactin in birds controls the moulting of feathers, as well as the age at onset of feathering in both turkeys and chickens. | [
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-4057742626596309727-hardneg-10 | Prolactin | In humans, prolactin is produced at least in the anterior pituitary, decidua, myometrium, breast, lymphocytes, leukocytes and prostate. | [
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] |
-4057742626596309727-hardneg-11 | Prolactin | In decidual cells and in lymphocytes the distal promoter and thus prolactin expression is stimulated by cAMP. Responsivness to cAMP is mediated by an imperfect cAMP–responsive element and two CAAT/enhancer binding proteins (C/EBP). Progesterone upregulates prolactin synthesis in the endometrium and decreases it in myometrium and breast glandular tissue. Breast and other tissues may express the Pit-1 promoter in addition to the distal promoter. | [
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-4057742626596309727-hardneg-12 | Prolactin | Extrapituitary production of prolactin is thought to be special to humans and primates and may serve mostly tissue-specific paracrine and autocrine purposes. It has been hypothesized that in vertebrates such as mice a similar tissue-specific effect is achieved by a large family of prolactin-like proteins controlled by at least 26 paralogous "PRL" genes not present in primates. | [
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-4057742626596309727-hardneg-13 | Prolactin | Vasoactive intestinal peptide and peptide histidine isoleucine help to regulate prolactin secretion in humans, but the functions of these hormones in birds can be quite different. | [
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-4057742626596309727-hardneg-14 | Prolactin | Prolactin follows diurnal and ovulatory cycles. Prolactin levels peak during REM sleep and in the early morning. Many mammals experience a seasonal cycle. | [
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-4057742626596309727-hardneg-15 | Prolactin | During pregnancy, high circulating concentrations of estrogen and progesterone increase prolactin levels by 10- to 20-fold. Estrogen and progesterone inhibit the stimulatory effects of prolactin on milk production. The abrupt drop of estrogen and progesterone levels following delivery allow prolactin—which temporarily remains high—to induce lactation. | [
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-4057742626596309727-hardneg-16 | Prolactin | In usual circumstances, in the absence of galactorrhea, lactation ceases within one or two weeks following the end of breastfeeding. | [
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-4057742626596309727-hardneg-17 | Prolactin | Levels can rise after exercise, high-protein meals, minor surgical procedures, following epileptic seizures or due to physical or emotional stress. In a study on female volunteers under hypnosis, prolactin surges resulted from the evocation, with rage, of humiliating experiences, but not from the fantasy of nursing. | [
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-4057742626596309727-hardneg-18 | Prolactin | The structure of prolactin is similar to that of growth hormone and placental lactogen. The molecule is folded due to the activity of three disulfide bonds. Significant heterogeneity of the molecule has been described, thus bioassays and immunoassays can give different results due to differing glycosylation, phosphorylation and sulfation, as well as degradation. The non-glycosylated form of prolactin is the dominant form that is secreted by the pituitary gland. | [
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-4057742626596309727-hardneg-19 | Prolactin | Prolactin levels may be checked as part of a sex hormone workup, as elevated prolactin secretion can suppress the secretion of follicle stimulating hormone and gonadotropin-releasing hormone, leading to hypogonadism and sometimes causing erectile dysfunction. | [
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-4057742626596309727-hardneg-20 | Prolactin | Prolactin levels may be of some use in distinguishing epileptic seizures from psychogenic non-epileptic seizures. The serum prolactin level usually rises following an epileptic seizure. | [
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] |
-4057742626596309727-hardneg-21 | Prolactin | The following chart illustrates the variations seen in normal prolactin measurements across different populations. Prolactin values were obtained from specific control groups of varying sizes using the IMMULITE assay. | [
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] |
-4057742626596309727-hardneg-22 | Prolactin | The following table illustrates variability in reference ranges of serum prolactin between some commonly used assay methods (as of 2008), using a control group of healthy health care professionals (53 males, age 20–64 years, median 28 years; 97 females, age 19–59 years, median 29 years) in Essex, England: | [
0.6331649422645569,
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0.4144597053527832,
0.6326280832290649,
0.6941325068473816,
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2.193286657333374,
0.4125761389732361,
0.21616651117801666,
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2.0739586353302,
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0.8557925820350647,
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0.8360371589660645,
0.4665030539035797,
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0.38788801431655884,
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1.2524524927139282,
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0.5838788747787476,
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1.4399241209030151,
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0.6547890305519104,
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1.073462963104248,
0.22735460102558136,
0.3186032474040985,
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2.034249782562256,
1.4785749912261963,
0.20315252244472504,
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] |
-4057742626596309727-hardneg-23 | Prolactin | An example of the use of the above table is, if using the Centaur assay to estimate prolactin values in µg/L for females, the mean is 7.92 µg/L and the reference range is 3.35–16.4 µg/L. | [
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-4057742626596309727-hardneg-24 | Prolactin | Hyperprolactinaemia, or excess serum prolactin, is associated with hypoestrogenism, anovulatory infertility, oligomenorrhoea, amenorrhoea, unexpected lactation and loss of libido in women and erectile dysfunction and loss of libido in men. | [
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-4057742626596309727-hardneg-25 | Prolactin | Hypoprolactinemia, or serum prolactin deficiency, is associated with ovarian dysfunction in women, and arteriogenic erectile dysfunction, premature ejaculation, oligozoospermia, asthenospermia, hypofunction of seminal vesicles and hypoandrogenism in men. In one study, normal sperm characteristics were restored when prolactin levels were raised to normal values in hypoprolactinemic men. | [
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-4057742626596309727-hardneg-26 | Prolactin | Hypoprolactinemia can result from hypopituitarism, excessive dopaminergic action in the tuberoinfundibular pathway and ingestion of D2 receptor agonists such as bromocriptine. | [
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-7832418849601935514-hardneg-0 | Child benefit | Child benefit or children's allowance is a social security payment which is distributed to the parents or guardians of children, teenagers and in some cases, young adults. A number of countries operate different versions of the program. In most countries, child benefit is means-tested and the amount of child benefit paid is usually dependent on the number of children one has. | [
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-7832418849601935514-hardneg-1 | Child benefit | A number of conditional cash transfer programs in Latin America and Africa link payment to the receivers' actions, such as enrolling children into schools, and health check-ups and vaccinations. In the UK, in 2011 CentreForum proposed an additional child benefit dependent on parenting activities. | [
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-7832418849601935514-hardneg-2 | Child benefit | On 1 July 2000 the Australian government introduced major changes to the tax system including the introduction of a broad-based Goods and Service Tax (a VAT), substantial income tax cuts, as well as major changes to assistance for families. | [
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-7832418849601935514-hardneg-3 | Child benefit | The Family Tax Benefit Part A is paid for dependent children up to 20 years of age, and for dependent full-time students up to the age of 24 (who are not getting Youth Allowance or similar payments such as ABSTUDY and Veterans' Children Education Supplement). It is essentially a two-tier but integrated payment directed to most families with children, with a higher rate for lower income families, including both those in work and receiving income support. | [
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-7832418849601935514-hardneg-4 | Child benefit | The maximum rate is paid up to a family income of $28,200, and is then reduced by 30 cents for every extra dollar of income, until the minimum rate is reached. Part-payment at the minimum rate is available up to a family income of $73,000 (plus an additional $3,000 for each dependent child after the first). Payments are then reduced by 30 cents in every dollar over that amount until the payment reaches nil. | [
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-7832418849601935514-hardneg-5 | Child benefit | To receive some Family Tax Benefit Part A, the maximum income levels are $76,256 a year for a family with one dependent child under 18 and $77,355 a year for a family with one dependent 18- to 24-year-old. These thresholds are lifted by $6,257 for each additional dependent child under 18 and $7,356 for each additional dependent 18- to 24-year-old. | [
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-7832418849601935514-hardneg-6 | Child benefit | Families receiving Family Tax Benefit Part A may also be eligible for extra payments, such as Rent Assistance if renting privately, the Large Family Supplement for four or more children, and Multiple Birth Allowance for three or more children born during the same birth. | [
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-7832418849601935514-hardneg-7 | Child benefit | The previous entry referred to Youth allowance and Parenting Payment. These are income support payments for young people and for parents who are not employed and looking after children respectively. | [
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-7832418849601935514-hardneg-8 | Child benefit | The Canada child benefit (CCB) is a tax-free monthly payment made to eligible families to help them with the cost of raising children under 18 years of age. Basic benefit for July 2019 to June 2020 is calculated as: | [
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-7832418849601935514-hardneg-9 | Child benefit | This amount is reduced for families with adjusted family net income (AFNI) over $31,120, based on AFNI and the number of children. | [
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-7832418849601935514-hardneg-10 | Child benefit | Child benefit scheme was introduced to Finland in 1948 by law. Since the 1920s there was a child benefit allowance that covered state workers with children. In 1948 this benefit became universal following the example of other Nordic countries. Benefit is paid for children until they turn 17, and it is only paid for children that live in Finland. There is also a supplement for single parents. Benefit is paid through national Finnish Social Insurance institution (KELA). Åland has a different scheme. | [
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-7832418849601935514-hardneg-11 | Child benefit | In Hungary there are several forms of family support. Every person who has a work permit and lives permanently in Hungary is eligible for almost all of them. | [
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-7832418849601935514-hardneg-12 | Child benefit | If the child misses more than 50 school hours without permission, the "family allowance" will be suspended until the child re-fulfills his/her school attendance obligation properly. In the case of pre-school age children, "family allowance" will be suspended in case of an unjustified absence exceeding 20 days of education. | [
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-7832418849601935514-hardneg-13 | Child benefit | According to some sources the government plans to raise the child benefit. However, there has been no official declaration on the issue. | [
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-7832418849601935514-hardneg-14 | Child benefit | The other one is called "family tax benefit" ("") which is a tax reduction for families according to the number of children living in the household. Its amount can be maximal 10,000 HUF for parents with one child, 15,000 HUF for parents with two children and 33,000 HUF for parents with three or more children per month. There are no differences between single and double households or between families with one or two parents employed. | [
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-7832418849601935514-hardneg-15 | Child benefit | People get "family allowance" and "family tax benefit" at the same time, so it is also common to count them together as a kind of "child benefit". | [
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-7832418849601935514-hardneg-16 | Child benefit | Child Benefit ("Sochar Leanaí") is payable to parents of children under 16 years of age, or under 18 years of age if they are in full-time education, Youthreach training or has a disability. The payment is paid by the Department of Social Protection. The monthly payments are as follows: | [
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-7832418849601935514-hardneg-17 | Child benefit | Multiple births are a special case. In the event of twins, 150% of the monthly payment is paid for each child. Triplets, or more, are paid the double (200%) rate each; provided that all of them remain qualified (i.e. stay in further education until 19). In addition, a special 'once-off' grant of €635 is paid on all multiple births. Further 'once-off' grants of €635 are paid when the children are 4 and 12 years old respectively. | [
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-7832418849601935514-hardneg-19 | Child benefit | The Luxembourg Government, through the "Caisse pour l'avenir des enfants" (Children's Future Fund), pays €271.66 per month per child. The allowance is universal and is not means-tested. | [
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-7832418849601935514-hardneg-20 | Child benefit | The family allowance is paid until the child turns 18, unless they continue in education, in which case it is paid until the adult child ceases being enrolled at an educational institution or turns 25 years old, whichever comes first. | [
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-7832418849601935514-hardneg-21 | Child benefit | The family allowance amount is increased by €200 per month for children who have a permanent disability causing them to lose at least 50% of their physical or mental capacity in comparison to a child of the same age with no disabilities. | [
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-7832418849601935514-hardneg-22 | Child benefit | In addition to the family allowance, a lump-sum back-to-school allowance is paid once a year in August for every child aged 6 or over enrolled at a primary or secondary school or college. | [
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-7832418849601935514-hardneg-23 | Child benefit | The allowance is €235 every August per child over 12 years old until their schooling comes to an end. | [
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-7832418849601935514-hardneg-24 | Child benefit | In 2021, the amount per child per month is: 55.75 euros for children aged 0 to 5 years; 67.75 euros for children aged 6 to 11 years; 79.75 euros per quarter for children from 12 to 17 years. | [
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-7832418849601935514-hardneg-25 | Child benefit | In comparison to Netherlands, its neighbour Germany pays 4 times more per month with lower income tax. | [
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-7832418849601935514-hardneg-26 | Child benefit | New Zealand has a tax rebate system known as 'Working For Families', which are allocated to families based on income and the number of children. A report in 2012 by the children's commissioner Dr Russell Wills recommended New Zealand adopt a universal child benefit, which the-then National government rejected. | [
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-7832418849601935514-hardneg-27 | Child benefit | In 2018, the Sixth Labour Government introduced a new universal BestStart Payment of $60 per week for parents with newborn dependents. | [
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-7832418849601935514-hardneg-28 | Child benefit | Between 2007 and 2010, Spain provided unconditional cash transfers to new mothers. The policy substantially increased the birth rate in Spain. | [
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-7832418849601935514-hardneg-29 | Child benefit | The system was first implemented in August 1946 as "family allowances" under the Family Allowances Act 1945, at a rate of 5"s" (= £0.25) per week per child in a family, except for the eldest. This was raised from September 1952, by the Family Allowances and National Insurance Act 1952, to 8"s" (= £0.40), and from October 1956, by the Family Allowances Act and National Insurance Act 1956, to 8"s" for the second child with 10"s" (= £0.50) for the third and subsequent children. | [
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-7832418849601935514-hardneg-30 | Child benefit | Today, child benefit is administered by Her Majesty's Revenue and Customs (HMRC). As of April 2015, this is £20.70 per week for the first child (including the eldest of a multiple birth) and £13.70 per week for each additional child. | [
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6640591955269665512-hardneg-0 | Neuron | A neuron or nerve cell is an electrically excitable cell that communicates with other cells via specialized connections called synapses. The neuron is the main component of nervous tissue in all animals except sponges and placozoa. Plants and fungi do not have nerve cells. | [
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6640591955269665512-hardneg-1 | Neuron | Most neurons receive signals via the dendrites and soma and send out signals down the axon. At the majority of synapses, signals cross from the axon of one neuron to a dendrite of another. However, synapses can connect an axon to another axon or a dendrite to another dendrite. | [
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6640591955269665512-hardneg-3 | Neuron | Axons may bundle into fascicles that make up the nerves in the peripheral nervous system (like strands of wire make up cables). Bundles of axons in the central nervous system are called tracts. | [
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6640591955269665512-hardneg-4 | Neuron | Neurons are highly specialized for the processing and transmission of cellular signals. Given their diversity of functions performed in different parts of the nervous system, there is a wide variety in their shape, size, and electrochemical properties. For instance, the soma of a neuron can vary from 4 to 100 micrometers in diameter. | [
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6640591955269665512-hardneg-6 | Neuron | Axons and dendrites in the central nervous system are typically only about one micrometer thick, while some in the peripheral nervous system are much thicker. The soma is usually about 10–25 micrometers in diameter and often is not much larger than the cell nucleus it contains. The longest axon of a human motor neuron can be over a meter long, reaching from the base of the spine to the toes. | [
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6640591955269665512-hardneg-7 | Neuron | Sensory neurons can have axons that run from the toes to the posterior column of the spinal cord, over 1.5 meters in adults. Giraffes have single axons several meters in length running along the entire length of their necks. Much of what is known about axonal function comes from studying the squid giant axon, an ideal experimental preparation because of its relatively immense size (0.5–1 millimeters thick, several centimeters long). | [
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6640591955269665512-hardneg-8 | Neuron | Fully differentiated neurons are permanently postmitotic however, stem cells present in the adult brain may regenerate functional neurons throughout the life of an organism (see neurogenesis). Astrocytes are star-shaped glial cells. They have been observed to turn into neurons by virtue of their stem cell-like characteristic of pluripotency. | [
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6640591955269665512-hardneg-9 | Neuron | There are different internal structural characteristics between axons and dendrites. Typical axons almost never contain ribosomes, except some in the initial segment. Dendrites contain granular endoplasmic reticulum or ribosomes, in diminishing amounts as the distance from the cell body increases. | [
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6640591955269665512-hardneg-10 | Neuron | Some unique neuronal types can be identified according to their location in the nervous system and distinct shape. Some examples are: | [
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6640591955269665512-hardneg-12 | Neuron | It is possible to identify the type of inhibitory effect a presynaptic neuron will have on a postsynaptic neuron, based on the proteins the presynaptic neuron expresses. Parvalbumin-expressing neurons typically dampen the output signal of the postsynaptic neuron in the visual cortex, whereas somatostatin-expressing neurons typically block dendritic inputs to the postsynaptic neuron. | [
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6640591955269665512-hardneg-13 | Neuron | Neurons have intrinsic electroresponsive properties like intrinsic transmembrane voltage oscillatory patterns. So neurons can be classified according to their electrophysiological characteristics: | [
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6640591955269665512-hardneg-15 | Neuron | #AMPA and Kainate receptors function as cation channels permeable to Na+ cation channels mediating fast excitatory synaptic transmission. | [
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6640591955269665512-hardneg-16 | Neuron | #NMDA receptors are another cation channel that is more permeable to Ca2+. The function of NMDA receptors depend on glycine receptor binding as a co-agonist within the channel pore. NMDA receptors do not function without both ligands present. | [
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6640591955269665512-hardneg-17 | Neuron | Glutamate can cause excitotoxicity when blood flow to the brain is interrupted, resulting in brain damage. When blood flow is suppressed, glutamate is released from presynaptic neurons, causing greater NMDA and AMPA receptor activation than normal outside of stress conditions, leading to elevated Ca2+ and Na+ entering the post synaptic neuron and cell damage. Glutamate is synthesized from the amino acid glutamine by the enzyme glutamate synthase. | [
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6640591955269665512-hardneg-18 | Neuron | Neurons communicate with each other via synapses, where either the axon terminal of one cell contacts another neuron's dendrite, soma or, less commonly, axon. Neurons such as Purkinje cells in the cerebellum can have over 1000 dendritic branches, making connections with tens of thousands of other cells; other neurons, such as the magnocellular neurons of the supraoptic nucleus, have only one or two dendrites, each of which receives thousands of synapses. | [
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6640591955269665512-hardneg-20 | Neuron | The human brain has some 8.6 x 1010 (eighty six billion) neurons. Each neuron has on average 7,000 synaptic connections to other neurons. It has been estimated that the brain of a three-year-old child has about 1015 synapses (1 quadrillion). This number declines with age, stabilizing by adulthood. Estimates vary for an adult, ranging from 1014 to 5 x 1014 synapses (100 to 500 trillion). | [
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6640591955269665512-hardneg-21 | Neuron | Beyond electrical and chemical signaling, studies suggest neurons in healthy human brains can also communicate through: | [
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6640591955269665512-hardneg-22 | Neuron | They can also get modulated by input from the environment and hormones released from other parts of the organism, which could be influenced more or less directly by neurons. This also applies to neurotrophins such as BDNF. The gut microbiome is also connected with the brain. | [
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6640591955269665512-hardneg-23 | Neuron | In 1937 John Zachary Young suggested that the squid giant axon could be used to study neuronal electrical properties. It is larger than but similar to human neurons, making it easier to study. By inserting electrodes into the squid giant axons, accurate measurements were made of the membrane potential. | [
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6640591955269665512-hardneg-24 | Neuron | The cell membrane of the axon and soma contain voltage-gated ion channels that allow the neuron to generate and propagate an electrical signal (an action potential). Some neurons also generate subthreshold membrane potential oscillations. These signals are generated and propagated by charge-carrying ions including sodium (Na+), potassium (K+), chloride (Cl−), and calcium (Ca2+). | [
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6640591955269665512-hardneg-25 | Neuron | Several stimuli can activate a neuron leading to electrical activity, including pressure, stretch, chemical transmitters, and changes of the electric potential across the cell membrane. Stimuli cause specific ion-channels within the cell membrane to open, leading to a flow of ions through the cell membrane, changing the membrane potential. Neurons must maintain the specific electrical properties that define their neuron type. | [
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6640591955269665512-hardneg-26 | Neuron | Some neurons do not generate action potentials, but instead generate a graded electrical signal, which in turn causes graded neurotransmitter release. Such non-spiking neurons tend to be sensory neurons or interneurons, because they cannot carry signals long distances. | [
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6640591955269665512-hardneg-27 | Neuron | Neural coding is concerned with how sensory and other information is represented in the brain by neurons. The main goal of studying neural coding is to characterize the relationship between the stimulus and the individual or ensemble neuronal responses, and the relationships among the electrical activities of the neurons within the ensemble. It is thought that neurons can encode both digital and analog information. | [
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6640591955269665512-hardneg-28 | Neuron | Other receptor types include quickly adapting or phasic receptors, where firing decreases or stops with steady stimulus; examples include skin which, when touched causes neurons to fire, but if the object maintains even pressure, the neurons stop firing. The neurons of the skin and muscles that are responsive to pressure and vibration have filtering accessory structures that aid their function. | [
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6640591955269665512-hardneg-29 | Neuron | The German anatomist Heinrich Wilhelm Waldeyer introduced the term "neuron" in 1891, based on the ancient Greek νεῦρον "neuron" 'sinew, cord, nerve'. | [
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6640591955269665512-hardneg-31 | Neuron | The neuron's place as the primary functional unit of the nervous system was first recognized in the late 19th century through the work of the Spanish anatomist Santiago Ramón y Cajal. | [
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6640591955269665512-hardneg-32 | Neuron | To make the structure of individual neurons visible, Ramón y Cajal improved a silver staining process that had been developed by Camillo Golgi. The improved process involves a technique called "double impregnation" and is still in use. | [
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6640591955269665512-hardneg-33 | Neuron | In 1888 Ramón y Cajal published a paper about the bird cerebellum. In this paper, he stated that he could not find evidence for anastomosis between axons and dendrites and called each nervous element "an absolutely autonomous canton." This became known as the neuron doctrine, one of the central tenets of modern neuroscience. | [
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6640591955269665512-hardneg-34 | Neuron | In 1891, the German anatomist Heinrich Wilhelm Waldeyer wrote a highly influential review of the neuron doctrine in which he introduced the term "neuron" to describe the anatomical and physiological unit of the nervous system. | [
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6640591955269665512-hardneg-35 | Neuron | The silver impregnation stains are a useful method for neuroanatomical investigations because, for reasons unknown, it stains only a small percentage of cells in a tissue, exposing the complete micro structure of individual neurons without much overlap from other cells. | [
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6640591955269665512-hardneg-36 | Neuron | The neuron doctrine is the now fundamental idea that neurons are the basic structural and functional units of the nervous system. The theory was put forward by Santiago Ramón y Cajal in the late 19th century. It held that neurons are discrete cells (not connected in a meshwork), acting as metabolically distinct units. | [
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6640591955269665512-hardneg-37 | Neuron | Later discoveries yielded refinements to the doctrine. For example, glial cells, which are non-neuronal, play an essential role in information processing. Also, electrical synapses are more common than previously thought, comprising direct, cytoplasmic connections between neurons. In fact, neurons can form even tighter couplings: the squid giant axon arises from the fusion of multiple axons. | [
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6640591955269665512-hardneg-38 | Neuron | Ramón y Cajal also postulated the Law of Dynamic Polarization, which states that a neuron receives signals at its dendrites and cell body and transmits them, as action potentials, along the axon in one direction: away from the cell body. The Law of Dynamic Polarization has important exceptions; dendrites can serve as synaptic output sites of neurons and axons can receive synaptic inputs. | [
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6640591955269665512-hardneg-39 | Neuron | Charcot–Marie–Tooth disease (CMT) is a heterogeneous inherited disorder of nerves (neuropathy) that is characterized by loss of muscle tissue and touch sensation, predominantly in the feet and legs extending to the hands and arms in advanced stages. Presently incurable, this disease is one of the most common inherited neurological disorders, affecting 36 in 100,000 people. | [
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6640591955269665512-hardneg-40 | Neuron | Myasthenia gravis is a neuromuscular disease leading to fluctuating muscle weakness and fatigability during simple activities. Weakness is typically caused by circulating antibodies that block acetylcholine receptors at the post-synaptic neuromuscular junction, inhibiting the stimulative effect of the neurotransmitter acetylcholine. Myasthenia is treated with immunosuppressants, cholinesterase inhibitors and, in selected cases, thymectomy. | [
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6640591955269665512-hardneg-41 | Neuron | Demyelination is the act of demyelinating, or the loss of the myelin sheath insulating the nerves. When myelin degrades, conduction of signals along the nerve can be impaired or lost, and the nerve eventually withers. This leads to certain neurodegenerative disorders like multiple sclerosis and chronic inflammatory demyelinating polyneuropathy. | [
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6640591955269665512-hardneg-42 | Neuron | Neurons are born through the process of neurogenesis, in which neural stem cells divide to produce differentiated neurons. Once fully differentiated neurons are formed, they are no longer capable of undergoing mitosis. Neurogenesis primarily occurs in the embryo of most organisms. | [
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