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6640591955269665512-hardneg-43 | Neuron | Adult neurogenesis can occur and studies of the age of human neurons suggest that this process occurs only for a minority of cells, and that the vast majority of neurons in the neocortex forms before birth and persists without replacement. The extent to which adult neurogenesis exists in humans, and its contribution to cognition are controversial, with conflicting reports published in 2018. | [
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6640591955269665512-hardneg-44 | Neuron | The body contains a variety of stem cell types that have the capacity to differentiate into neurons. Researchers found a way to transform human skin cells into nerve cells using transdifferentiation, in which "cells are forced to adopt new identities". | [
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6640591955269665512-hardneg-45 | Neuron | At different stages of mammalian nervous system development two DNA repair processes are employed in the repair of DNA double-strand breaks. These pathways are homologous recombinational repair used in proliferating neural precursor cells, and non-homologous end joining used mainly at later developmental stages | [
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6640591955269665512-hardneg-46 | Neuron | Peripheral axons can regrow if they are severed, but one neuron cannot be functionally replaced by one of another type (Llinás' law). | [
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-2937766636613639776-hardneg-0 | Coagulation | Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The mechanism of coagulation involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin. | [
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-2937766636613639776-hardneg-1 | Coagulation | Disorders of coagulation are disease states which can result in problems with hemorrhage, bruising, or thrombosis. | [
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-2937766636613639776-hardneg-2 | Coagulation | Coagulation is highly conserved throughout biology. In all mammals, coagulation involves both cellular components (platelets) and proteinaceous components (here, coagulation factors). The pathway in humans has been the most extensively researched and is the best understood. | [
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-2937766636613639776-hardneg-3 | Coagulation | The coagulation factors are generally enzymes called serine proteases, which act by cleaving downstream proteins. The exceptions are tissue factor, FV, FVIII, FXIII. Tissue factor, FV and FVIII are glycoproteins, and Factor XIII is a transglutaminase. The coagulation factors circulate as inactive zymogens. | [
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-2937766636613639776-hardneg-4 | Coagulation | The coagulation cascade is therefore classically divided into three pathways. The "tissue factor" and "contact activation" pathways both activate the "final common pathway" of factor X, thrombin and fibrin. | [
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-2937766636613639776-hardneg-5 | Coagulation | The main role of the tissue factor (TF) pathway is to generate a "thrombin burst", a process by which thrombin, the most important constituent of the coagulation cascade in terms of its feedback activation roles is released very rapidly. FVIIa circulates in a higher amount than any other activated coagulation factor. The process includes the following steps: | [
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-2937766636613639776-hardneg-6 | Coagulation | The division of coagulation in two pathways is arbitrary, originating from laboratory tests in which clotting times were measured either after the clotting was initiated by glass, the intrinsic pathway; or clotting was initiated by thromboplastin (a mix of tissue factor and phospholipids), the extrinsic pathway. | [
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-2937766636613639776-hardneg-7 | Coagulation | Further, the final common pathway scheme implies that prothrombin is converted to thrombin only when acted upon by the intrinsic or extrinsic pathways, which is an oversimplification. In fact, thrombin is generated by activated platelets at the initiation of the platelet plug, which in turn promotes more platelet activation. | [
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-2937766636613639776-hardneg-8 | Coagulation | Thrombin functions not only to convert fibrinogen to fibrin, it also activates Factors VIII and V and their inhibitor protein C (in the presence of thrombomodulin); and it activates Factor XIII, which forms covalent bonds that crosslink the fibrin polymers that form from activated monomers. | [
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-2937766636613639776-hardneg-9 | Coagulation | The coagulation cascade is maintained in a prothrombotic state by the continued activation of FVIII and FIX to form the tenase complex until it is down-regulated by the anticoagulant pathways. | [
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-2937766636613639776-hardneg-10 | Coagulation | A newer model of coagulation mechanism explains the intricate combination of cellular and biochemical events that occur during the coagulation process "in vivo". Along with the procoagulant and anticoagulant plasma proteins, normal physiologic coagulation requires the presence of two cell types for formation of coagulation complexes: cells that express tissue factor (usually extravascular) and platelets. | [
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-2937766636613639776-hardneg-11 | Coagulation | Five mechanisms keep platelet activation and the coagulation cascade in check. Abnormalities can lead to an increased tendency toward thrombosis: | [
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-2937766636613639776-hardneg-12 | Coagulation | Antithrombin is a serine protease inhibitor (serpin) that degrades the serine proteases: thrombin, FIXa, FXa, FXIa, and FXIIa. It is constantly active, but its adhesion to these factors is increased by the presence of heparan sulfate (a glycosaminoglycan) or the administration of heparins (different heparinoids increase affinity to FXa, thrombin, or both). Quantitative or qualitative deficiency of antithrombin (inborn or acquired, e.g., in proteinuria) leads to thrombophilia. | [
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-2937766636613639776-hardneg-13 | Coagulation | Tissue factor pathway inhibitor (TFPI) limits the action of tissue factor (TF). It also inhibits excessive TF-mediated activation of FVII and FX. | [
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-2937766636613639776-hardneg-14 | Coagulation | Plasmin is generated by proteolytic cleavage of plasminogen, a plasma protein synthesized in the liver. This cleavage is catalyzed by tissue plasminogen activator (t-PA), which is synthesized and secreted by endothelium. Plasmin proteolytically cleaves fibrin into fibrin degradation products that inhibit excessive fibrin formation. | [
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-2937766636613639776-hardneg-15 | Coagulation | Prostacyclin (PGI2) is released by endothelium and activates platelet Gs protein-linked receptors. This, in turn, activates adenylyl cyclase, which synthesizes cAMP. cAMP inhibits platelet activation by decreasing cytosolic levels of calcium and, by doing so, inhibits the release of granules that would lead to activation of additional platelets and the coagulation cascade. | [
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-2937766636613639776-hardneg-16 | Coagulation | Eventually, blood clots are reorganized and resorbed by a process termed "fibrinolysis". The main enzyme responsible for this process (plasmin) is regulated by various activators and inhibitors. | [
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-2937766636613639776-hardneg-17 | Coagulation | The contact activation (intrinsic) pathway is initiated by activation of the "contact factors" of plasma, and can be measured by the activated partial thromboplastin time (aPTT) test. | [
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-2937766636613639776-hardneg-18 | Coagulation | The tissue factor (extrinsic) pathway is initiated by release of tissue factor (a specific cellular lipoprotein), and can be measured by the prothrombin time (PT) test. PT results are often reported as ratio (INR value) to monitor dosing of oral anticoagulants such as warfarin. | [
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-2937766636613639776-hardneg-19 | Coagulation | The quantitative and qualitative screening of fibrinogen is measured by the thrombin clotting time (TCT). Measurement of the exact amount of fibrinogen present in the blood is generally done using the Clauss method for fibrinogen testing. Many analysers are capable of measuring a "derived fibrinogen" level from the graph of the Prothrombin time clot. | [
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-2937766636613639776-hardneg-20 | Coagulation | Coagulation defects may cause hemorrhage or thrombosis, and occasionally both, depending on the nature of the defect. | [
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-2937766636613639776-hardneg-21 | Coagulation | The best-known coagulation factor disorders are the hemophilias. The three main forms are hemophilia A (factor VIII deficiency), hemophilia B (factor IX deficiency or "Christmas disease") and hemophilia C (factor XI deficiency, mild bleeding tendency). | [
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] |
-2937766636613639776-hardneg-22 | Coagulation | Von Willebrand disease (which behaves more like a platelet disorder except in severe cases), is the most common hereditary bleeding disorder and is characterized as being inherited autosomal recessive or dominant. In this disease, there is a defect in von Willebrand factor (vWF), which mediates the binding of glycoprotein Ib (GPIb) to collagen. This binding helps mediate the activation of platelets and formation of primary hemostasis. | [
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-2937766636613639776-hardneg-23 | Coagulation | In acute or chronic liver failure, there is insufficient production of coagulation factors, possibly increasing risk of bleeding during surgery. | [
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] |
-2937766636613639776-hardneg-24 | Coagulation | The use of adsorbent chemicals, such as zeolites, and other hemostatic agents are also used for sealing severe injuries quickly (such as in traumatic bleeding secondary to gunshot wounds). Thrombin and fibrin glue are used surgically to treat bleeding and to thrombose aneurysms. Hemostatic Powder Spray TC-325 is used to treated gastrointestinal bleeding. | [
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-2937766636613639776-hardneg-25 | Coagulation | Coagulation factor concentrates are used to treat hemophilia, to reverse the effects of anticoagulants, and to treat bleeding in people with impaired coagulation factor synthesis or increased consumption. Prothrombin complex concentrate, cryoprecipitate and fresh frozen plasma are commonly used coagulation factor products. Recombinant activated human factor VII is increasingly popular in the treatment of major bleeding. | [
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-2937766636613639776-hardneg-26 | Coagulation | Tranexamic acid and aminocaproic acid inhibit fibrinolysis and lead to a "de facto" reduced bleeding rate. Before its withdrawal, aprotinin was used in some forms of major surgery to decrease bleeding risk and the need for blood products. | [
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-2937766636613639776-hardneg-27 | Coagulation | The theory that thrombin is generated by the presence of tissue factor was consolidated by Paul Morawitz in 1905. At this stage, it was known that "thrombokinase/thromboplastin" (factor III) is released by damaged tissues, reacting with "prothrombin" (II), which, together with calcium (IV), forms "thrombin", which converts fibrinogen into "fibrin" (I). | [
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-2937766636613639776-hardneg-28 | Coagulation | The remainder of the biochemical factors in the process of coagulation were largely discovered in the 20th century. | [
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-2937766636613639776-hardneg-29 | Coagulation | A first clue as to the actual complexity of the system of coagulation was the discovery of "proaccelerin" (initially and later called Factor V) by (1905–1990) in 1947. He also postulated its function to be the generation of accelerin (Factor VI), which later turned out to be the activated form of V (or Va); hence, VI is not now in active use. | [
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-2937766636613639776-hardneg-30 | Coagulation | Factor VII (also known as "serum prothrombin conversion accelerator" or "proconvertin", precipitated by barium sulfate) was discovered in a young female patient in 1949 and 1951 by different groups. | [
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-2937766636613639776-hardneg-31 | Coagulation | Factor VIII turned out to be deficient in the clinically recognized but etiologically elusive hemophilia A; it was identified in the 1950s and is alternatively called "antihemophilic globulin" due to its capability to correct hemophilia A. | [
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] |
-2937766636613639776-hardneg-32 | Coagulation | Factor IX was discovered in 1952 in a young patient with hemophilia B named Stephen Christmas (1947–1993). His deficiency was described by Dr. Rosemary Biggs and Professor R.G. MacFarlane in Oxford, UK. The factor is, hence, called Christmas Factor. Christmas lived in Canada and campaigned for blood transfusion safety until succumbing to transfusion-related AIDS at age 46. An alternative name for the factor is "plasma thromboplastin component", given by an independent group in California. | [
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] |
-2937766636613639776-hardneg-33 | Coagulation | Hageman factor, now known as factor XII, was identified in 1955 in an asymptomatic patient with a prolonged bleeding time named of John Hageman. Factor X, or Stuart-Prower factor, followed, in 1956. This protein was identified in a Ms. Audrey Prower of London, who had a lifelong bleeding tendency. In 1957, an American group identified the same factor in a Mr. Rufus Stuart. Factors XI and XIII were identified in 1953 and 1961, respectively. | [
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-2937766636613639776-hardneg-34 | Coagulation | The view that the coagulation process is a "cascade" or "waterfall" was enunciated almost simultaneously by MacFarlane in the UK and by Davie and Ratnoff in the US, respectively. | [
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-2937766636613639776-hardneg-35 | Coagulation | Factors III and VI are unassigned, as thromboplastin was never identified, and actually turned out to consist of ten further factors, and accelerin was found to be activated Factor V. | [
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-2937766636613639776-hardneg-36 | Coagulation | All mammals have an extremely closely related blood coagulation process, using a combined cellular and serine protease process. In fact, it is possible for any mammalian coagulation factor to "cleave" its equivalent target in any other mammal. The only non-mammalian animal known to use serine proteases for blood coagulation is the horseshoe crab. | [
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-5733715803549946687-hardneg-0 | State of Palestine | In 1964, when the West Bank was controlled by Jordan, the Palestine Liberation Organization was established there with the goal to confront Israel. The Palestinian National Charter of the PLO defines the boundaries of Palestine as the whole remaining territory of the mandate, including Israel. Following the Six-Day War, the PLO moved to Jordan, but later relocated to Lebanon in 1971. | [
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-5733715803549946687-hardneg-1 | State of Palestine | The State of Palestine has been recognized by 138 of the 193 UN members and since 2012 has had a status of a non-member observer state in the United Nations. | [
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-5733715803549946687-hardneg-2 | State of Palestine | On 29 November 2012, in a 138–9 vote (with 41 abstentions and 5 absences), the United Nations General Assembly passed resolution 67/19, upgrading Palestine from an "observer entity" to a "non-member observer state" within the United Nations system, which was described as recognition of the PLO's sovereignty. Palestine's new status is equivalent to that of the Holy See. | [
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] |
-5733715803549946687-hardneg-3 | State of Palestine | The areas claimed by the State of Palestine lie in the Levant. The Gaza Strip borders the Mediterranean Sea to the west, Egypt to the south, and Israel to the north and east. The West Bank is bordered by Jordan to the east, and Israel to the north, south, and west. Thus, the two enclaves constituting the area claimed by State of Palestine have no geographical border with one another, being separated by Israel. These areas would constitute the world's 163rd largest country by land area. | [
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-5733715803549946687-hardneg-4 | State of Palestine | Palestine has a number of environmental issues; issues facing the Gaza Strip include desertification; salination of fresh water; sewage treatment; water-borne diseases; soil degradation; and depletion and contamination of underground water resources. In the West Bank, many of the same issues apply; although fresh water is much more plentiful, access is restricted by the ongoing dispute. | [
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-5733715803549946687-hardneg-5 | State of Palestine | Three terrestrial ecoregions are found in the area: Eastern Mediterranean conifer-sclerophyllous-broadleaf forests, Arabian Desert, and Mesopotamian shrub desert. | [
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-5733715803549946687-hardneg-6 | State of Palestine | The State of Palestine consists of the following institutions that are associated with the Palestine Liberation Organization (PLO): | [
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-5733715803549946687-hardneg-7 | State of Palestine | These should be distinguished from the President of the Palestinian National Authority, Palestinian Legislative Council (PLC) and PNA Cabinet, all of which are instead associated with the Palestinian National Authority. | [
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-5733715803549946687-hardneg-8 | State of Palestine | The State of Palestine's founding document is the Palestinian Declaration of Independence, and it should be distinguished from the unrelated PLO Palestinian National Covenant and PNA Palestine Basic Law. | [
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-5733715803549946687-hardneg-9 | State of Palestine | On 15 December 1988, the State of Palestine's declaration of independence of November 1988 was acknowledged in the General Assembly with Resolution 43/177. | [
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-5733715803549946687-hardneg-10 | State of Palestine | () of the member states of the United Nations have recognised the State of Palestine. Many of the countries that do not recognise the State of Palestine nevertheless recognise the PLO as the "representative of the Palestinian people". The PLO's executive committee is empowered by the PNC to perform the functions of government of the State of Palestine. | [
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-5733715803549946687-hardneg-11 | State of Palestine | On 29 November 2012, UN General Assembly resolution 67/19 passed, upgrading Palestine to "non-member observer state" status in the United Nations. The change in status was described as ""de facto" recognition of the sovereign state of Palestine". | [
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-5733715803549946687-hardneg-12 | State of Palestine | On 2 December 2014, the French parliament voted by 331 to 151 in favour of urging their government to recognise Palestine as a state. The text, proposed by the ruling Socialists and backed by left-wing parties and some conservatives, asked the government to "use the recognition of a Palestinian state with the aim of resolving the conflict definitively". | [
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-5733715803549946687-hardneg-13 | State of Palestine | On 31 December 2014, the United Nations Security Council voted down a resolution demanding the end of Israeli occupation and statehood by 2017. Eight members voted for the Resolution (Russia, China, France, Argentina, Chad, Chile, Jordan, Luxembourg), however following strenuous US and Israeli efforts to defeat the resolution, it did not get the minimum of nine votes needed to pass the resolution. Australia and the United States voted against the resolution, with five other nations abstaining. | [
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-5733715803549946687-hardneg-14 | State of Palestine | On 16 January 2015, the International Criminal Court announced that, since Palestine was granted observer State status in the UN by the UNGA, it must be considered a "State" for the purposes of accession to the Rome Statute. | [
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-5733715803549946687-hardneg-15 | State of Palestine | On 13 May 2015, the Vatican announced it was shifting recognition from the PLO to the State of Palestine, confirming recognition of Palestine as a state after the UN vote of 2012. Monsignor Antoine Camilleri, Vatican foreign minister, said the change was in line with the evolving position of the Holy See, which has referred unofficially to the State of Palestine since Pope Francis's visit to the Holy Land in May 2014. | [
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-5733715803549946687-hardneg-16 | State of Palestine | In August 2015, Palestine's representatives at the UN presented a draft resolution that would allow the non-member observer states Palestine and the Holy See to raise their flags at the United Nations headquarters. Initially, the Palestinians presented their initiative as a joint effort with the Holy See, which the Holy See denied. | [
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-5733715803549946687-hardneg-17 | State of Palestine | In a letter to the Secretary General and the President of the General Assembly, Israel's Ambassador at the UN Ron Prosor called the step "another cynical misuse of the UN ... in order to score political points". | [
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-5733715803549946687-hardneg-18 | State of Palestine | After the vote, which was passed by 119 votes to 8 with 45 countries abstaining, the US Ambassador Samantha Power said that "raising the Palestinian flag will not bring Israelis and Palestinians any closer together". US Department of State spokesman Mark Toner called it a "counterproductive" attempt to pursue statehood claims outside of a negotiated settlement. | [
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-5733715803549946687-hardneg-19 | State of Palestine | At the ceremony itself, U.N. Secretary-General Ban Ki-moon said the occasion was a "day of pride for the Palestinian people around the world, a day of hope", and declared "Now is the time to restore confidence by both Israelis and Palestinians for a peaceful settlement and, at last, the realization of two states for two peoples." | [
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-5733715803549946687-hardneg-20 | State of Palestine | There are a wide variety of views regarding the status of the State of Palestine, both among the states of the international community and among legal scholars. The existence of a state of Palestine, although controversial, is a reality in the opinions of the states that have established bilateral diplomatic relations. | [
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-5733715803549946687-hardneg-21 | State of Palestine | The State of Palestine has a number of security forces, including a Civil Police Force, National Security Forces and Intelligence Services, with the function of maintaining security and protecting Palestinian citizens and the Palestinian State. | [
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-5733715803549946687-hardneg-22 | State of Palestine | According to the Palestinian Central Bureau of Statistics, the State of Palestine had population of 4,420,549 people in 2013. Within an area of , there is a population density of about 827 people per square kilometre. To put this in a wider context, the average population density of the world was 25 people per square kilometre as of 2017. | [
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-5733715803549946687-hardneg-23 | State of Palestine | According to the Palestinian Ministry of Health (MOH), as of 2017, there were 743 primary health care centers in Palestine (583 in the West Bank and 160 in Gaza), and 81 hospitals (51 in the West Bank, including East Jerusalem, and 30 in Gaza). | [
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-5733715803549946687-hardneg-24 | State of Palestine | Operating under the auspices of the World Health Organization (WHO), the Health Cluster for the occupied Palestinian territory (oPt) was established in 2009 and represents a partnership of over 70 local and international nongovernmental organisations and UN agencies providing a framework for health actors involved in the humanitarian response for the oPt. The Cluster is co-chaired by the MOH to ensure alignment with national policies and plans. | [
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-5733715803549946687-hardneg-25 | State of Palestine | The report of WHO Director-General of 1 May 2019 describes health sector conditions in the oPt identifying strategic priorities and current obstacles to their achievement pursuant to the country cooperation strategy for WHO and the Occupied Palestinian Territory 2017–2020. | [
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-5733715803549946687-hardneg-26 | State of Palestine | The literacy rate of Palestine was 96.3% according to a 2014 report by the United Nations Development Programme, which is high by international standards. There is a gender difference in the population aged above 15 with 5.9% of women considered illiterate compared to 1.6% of men. Illiteracy among women has fallen from 20.3% in 1997 to less than 6% in 2014. | [
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-5733715803549946687-hardneg-27 | State of Palestine | 93% of Palestinians are Muslim, the vast majority of whom are followers of the Sunni branch of Islam, with a small minority of Ahmadiyya, and 15% being nondenominational Muslims. Palestinian Christians represent a significant minority of 6%, followed by much smaller religious communities, including Druze and Samaritans. | [
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-5733715803549946687-hardneg-28 | State of Palestine | On 12 June 2020, the World Bank approved a US$15 million grant for the Technology for Youth and Jobs (TechStart) Project aiming to help the Palestinian IT sector upgrade the capabilities of firms and create more high-quality jobs. Kanthan Shankar, World Bank Country Director for West Bank and Gaza said "The IT sector has the potential to make a strong contribution to economic growth. It can offer opportunities to Palestinian youth, who constitute 30% of the population and suffer from acute unemployment." | [
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-5733715803549946687-hardneg-29 | State of Palestine | The Palestine Monetary Authority has issued guidelines for the operation and provision of electronic payment services including e-wallet and prepaid cards. | [
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-5733715803549946687-hardneg-30 | State of Palestine | Water supply and sanitation in the Palestinian territories are characterized by severe water shortage and are highly influenced by the Israeli occupation. The water resources of Palestine are fully controlled by Israel and the division of groundwater is subject to provisions in the Oslo II Accord. | [
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-5733715803549946687-hardneg-31 | State of Palestine | Generally, the water quality is considerably worse in the Gaza strip when compared to the West Bank. About a third to half of the delivered water in the Palestinian territories is lost in the distribution network. The lasting blockade of the Gaza Strip and the Gaza War have caused severe damage to the infrastructure in the Gaza Strip. | [
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-5733715803549946687-hardneg-32 | State of Palestine | Concerning wastewater, the existing treatment plants do not have the capacity to treat all of the produced wastewater, causing severe water pollution. The development of the sector highly depends on external financing. | [
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-5733715803549946687-hardneg-33 | State of Palestine | There are a number of newspapers, news agencies, and satellite television stations in the State of Palestine. Its news agencies include Ma'an News Agency, Wafa, Palestine News Network. Al-Aqsa TV, Al-Quds TV, Sanabel TV are its main satellite broadcasters. | [
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-5733715803549946687-hardneg-34 | State of Palestine | Association football (soccer) is the most popular sport among the Palestinian people. The Palestine national football team represents the country in international football. Rugby is also a popular sport. | [
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-7601725997240567725-hardneg-0 | Atmosphere of Earth | The atmosphere of Earth, commonly known as air, is the layer of gases retained by Earth's gravity that surrounds the planet and forms its planetary atmosphere. The atmosphere of Earth protects life on Earth by creating pressure allowing for liquid water to exist on the Earth's surface, absorbing ultraviolet solar radiation, warming the surface through heat retention (greenhouse effect), and reducing temperature extremes between day and night (the diurnal temperature variation). | [
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-7601725997240567725-hardneg-1 | Atmosphere of Earth | By mole fraction (i.e., by number of molecules), dry air contains 78.08% nitrogen, 20.95% oxygen, 0.93% argon, 0.04% carbon dioxide, and small amounts of other gases. | [
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-7601725997240567725-hardneg-2 | Atmosphere of Earth | Air also contains a variable amount of water vapor, on average around 1% at sea level, and 0.4% over the entire atmosphere. Air composition, temperature, and atmospheric pressure vary with altitude. Within the atmosphere, air suitable for use in photosynthesis by terrestrial plants and breathing of terrestrial animals is found only in Earth's troposphere. | [
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-7601725997240567725-hardneg-3 | Atmosphere of Earth | Earth's early atmosphere consisted of gases in the solar nebula, primarily hydrogen. The atmosphere changed significantly over time, affected by many factors such as volcanism, life, and weathering. Recently, human activity has also contributed to atmospheric changes, such as global warming, ozone depletion and acid deposition. | [
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-7601725997240567725-hardneg-4 | Atmosphere of Earth | The study of Earth's atmosphere and its processes is called atmospheric science (aerology), and includes multiple subfields, such as climatology and atmospheric physics. Early pioneers in the field include Léon Teisserenc de Bort and Richard Assmann. The study of historic atmosphere is called paleoclimatology. | [
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-7601725997240567725-hardneg-5 | Atmosphere of Earth | The average molecular weight of dry air, which can be used to calculate densities or to convert between mole fraction and mass fraction, is about 28.946 or 28.96 g/mol. This is decreased when the air is humid. | [
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-7601725997240567725-hardneg-6 | Atmosphere of Earth | The exosphere is the outermost layer of Earth's atmosphere (i.e. the upper limit of the atmosphere). It extends from the thermopause, at the top of the thermosphere at an altitude of about 700 km above sea level, to about 10,000 km (6,200 mi; 33,000,000 ft), where it merges into the solar wind. | [
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-7601725997240567725-hardneg-7 | Atmosphere of Earth | The exosphere is too far above Earth for meteorological phenomena to be possible. However, Earth's auroras—the aurora borealis (northern lights) and aurora australis (southern lights)—sometimes occur in the lower part of the exosphere, where they overlap into the thermosphere. The exosphere contains many of the artificial satellites that orbit Earth. | [
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-7601725997240567725-hardneg-8 | Atmosphere of Earth | The thermosphere is the second-highest layer of Earth's atmosphere. It extends from the mesopause (which separates it from the mesosphere) at an altitude of about up to the thermopause at an altitude range of . The height of the thermopause varies considerably due to changes in solar activity. Because the thermopause lies at the lower boundary of the exosphere, it is also referred to as the exobase. The lower part of the thermosphere, from above Earth's surface, contains the ionosphere. | [
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-7601725997240567725-hardneg-9 | Atmosphere of Earth | This layer is completely cloudless and free of water vapor. However, non-hydrometeorological phenomena such as the aurora borealis and aurora australis are occasionally seen in the thermosphere. The International Space Station orbits in this layer, between . It is this layer where many of the satellites orbiting the earth are present. | [
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-7601725997240567725-hardneg-10 | Atmosphere of Earth | The mesosphere is the third highest layer of Earth's atmosphere, occupying the region above the stratosphere and below the thermosphere. It extends from the stratopause at an altitude of about to the mesopause at above sea level. | [
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-7601725997240567725-hardneg-12 | Atmosphere of Earth | The stratosphere is the second-lowest layer of Earth's atmosphere. It lies above the troposphere and is separated from it by the tropopause. This layer extends from the top of the troposphere at roughly above Earth's surface to the stratopause at an altitude of about . | [
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-7601725997240567725-hardneg-13 | Atmosphere of Earth | The troposphere is the lowest layer of Earth's atmosphere. It extends from Earth's surface to an average height of about , although this altitude varies from about at the geographic poles to at the Equator, with some variation due to weather. The troposphere is bounded above by the tropopause, a boundary marked in most places by a temperature inversion (i.e. a layer of relatively warm air above a colder one), and in others by a zone that is isothermal with height. | [
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-7601725997240567725-hardneg-16 | Atmosphere of Earth | Air pressure actually decreases exponentially with altitude, dropping by half every or by a factor of 1/e (0.368) every , (this is called the scale height) -- for altitudes out to around . However, the atmosphere is more accurately modeled with a customized equation for each layer that takes gradients of temperature, molecular composition, solar radiation and gravity into account. At heights over 100 km, an atmosphere may no longer be well mixed. Then each chemical species has its own scale height. | [
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-7601725997240567725-hardneg-17 | Atmosphere of Earth | commercial airliners typically cruise between where the lower density and temperature of the air improve fuel economy; weather balloons reach and above; and the highest X-15 flight in 1963 reached . | [
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-7601725997240567725-hardneg-18 | Atmosphere of Earth | Because in an ideal gas of constant composition the speed of sound depends only on temperature and not on pressure or density, the speed of sound in the atmosphere with altitude takes on the form of the complicated temperature profile (see illustration to the right), and does not mirror altitudinal changes in density or pressure. | [
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-7601725997240567725-hardneg-19 | Atmosphere of Earth | The density of air at sea level is about 1.2 kg/m3 (1.2 g/L, 0.0012 g/cm3). Density is not measured directly but is calculated from measurements of temperature, pressure and humidity using the equation of state for air (a form of the ideal gas law). Atmospheric density decreases as the altitude increases. This variation can be approximately modeled using the barometric formula. More sophisticated models are used to predict the orbital decay of satellites. | [
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-7601725997240567725-hardneg-20 | Atmosphere of Earth | The average mass of the atmosphere is about 5 quadrillion (5) tonnes or 1/1,200,000 the mass of Earth. According to the American National Center for Atmospheric Research, "The total mean mass of the atmosphere is 5.1480 kg with an annual range due to water vapor of 1.2 or 1.5 kg, depending on whether surface pressure or water vapor data are used; somewhat smaller than the previous estimate. The mean mass of water vapor is estimated as 1.27 kg and the dry air mass as 5.1352 ±0.0003 kg." | [
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-7601725997240567725-hardneg-21 | Atmosphere of Earth | Solar radiation (or sunlight) is the energy Earth receives from the Sun. Earth also emits radiation back into space, but at longer wavelengths that humans cannot see. Part of the incoming and emitted radiation is absorbed or reflected by the atmosphere. In May 2017, glints of light, seen as twinkling from an orbiting satellite a million miles away, were found to be reflected light from ice crystals in the atmosphere. | [
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-7601725997240567725-hardneg-22 | Atmosphere of Earth | Different molecules absorb different wavelengths of radiation. For example, O2 and O3 absorb almost all radiation with wavelengths shorter than 300 nanometers. Water (H2O) absorbs at many wavelengths above 700 nm. When a molecule absorbs a photon, it increases the energy of the molecule. This heats the atmosphere, but the atmosphere also cools by emitting radiation, as discussed below. | [
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-7601725997240567725-hardneg-23 | Atmosphere of Earth | Because of its temperature, the atmosphere emits infrared radiation. For example, on clear nights Earth's surface cools down faster than on cloudy nights. This is because clouds (H2O) are strong absorbers and emitters of infrared radiation. This is also why it becomes colder at night at higher elevations. | [
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