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Conclusion: People all agree that the Covid-19 vaccine brings benefits that outweigh the risks.
Adverse reactions occurred such as mild fever, headache, fatigue, muscle pain... No serious events requiring hospitalization were recorded.
Detection of TP53 gene mutation and IGHV gene mutation status in chronic lymphocytic leukemia at Blood transfusion hematology hospital
The purpose of this study was to investigate the clinical characteristics and the factors associated with external ventricular drainage (EVD) - related ventriculitis in patients with intraventricular hemorrhage (IVH) undergoing EVD.
We did a retrospective observational study of patients with IVH undergoing EVD admitted to the Center for Emergency Medicine of Bach Mai Hospital in Hanoi, Vietnam between January 2015 and February 2021.
Of 124 patients, 24.2% had EVD - related ventriculitis.
On admission, the median Glasgow Coma Score was 7 (IQR: 6.00 - 8.75), and the mean serum glucose level was 9.61 (SD: 2.80) mmol / L.
Hospital - acquired pneumonia occurred in 41.5% (51/123) of patients.
In a multivariate analysis, hospital - acquired pneumonia (odds ratio, OR: 2.641; 95% confidence interval, CI: 1.056 - 6.602) was independently associated with an increased risk of EVD - related ventriculitis.
Additionally, serum glucose level ≥11.10 mmol / L (OR: 2.618; 95% CI: 0.969 - 7.069) also tended to be related to patients with EVD - related ventriculitis.
Thus, to decrease the rate of EVD - related ventriculitis, the prevention of EVD - related ventriculitis needs to be enhanced through improving both prevention and treatment of hospital - acquired pneumonia and treating hyperglycemia more optimally in patients with IVH undergoing EVD.
Characteristics and in-vitro resistance to bacteria causing community- acquired pneumonia at Ho Chi Minh city university medical center 2020
We initially investigated TP53 gene mutation and IGHV gene mutation status in patients with chronic lymphocytic leukemia (CLL) diagnosed at the Blood Transfusion and Hematology Hospital (BTH).
Method: A case series.
We used PCR techniques, Sanger sequencing and analyse TP53 and IGHV gene sequences by SeqScape and IMGT software to identify TP53 gene mutations and IGHV gene mutation status in patients diagnosed with CLL at BTH.
Results: From December 2021 to June 2022, peripheral blood samples from 7 cases of CLL were collected and performed DNA sequencing to identify mutations in the TP53 gene, but no cases of TP53 gene mutations were found.
Next, we determined the mutation status of IGHV gene on these patients, there were 3 cases without IGHV gene mutation (≥ 98% identity to the germline sequence) and 4 cases with IGHV gene mutation (< 98% identity to the germline sequence).
Conclusions: Thus, the TP53 gene mutation and the IGHV gene mutation status are useful markers for prognostic classification more accurately and guide for an appropriate treatment decision for each CLL patient.
Outcomes of decitabine monotherapy for elderly acute myeloid leukemia patients in the National institute of hematology and blood transfusion during 2019-2021
Investigating characteristics and in-vitro resistance to bacteria causing community-acquired pneumonia at HCMC University Medical Center 2020.
P aeruginosae had relatively low resistance to Ceftazidime, Piperacillin / Tazobactam, Levofloxacin.
K pneumoniae had relatively low resistance to Amikacin, Piperacillin / Tazobactam, Levofloxacin.
Conclusion: Gram-positive bacteria accounted for the majority compared to gram-negative bacteria.
The most common strains was K pneumoniae, S pneumoniae, P aeruginosae, Staphylococcus spp.
Bacteria caused CAP are multiform and increasing high antibiotic resistance.
Methods: 224 community - acquired pneumonia patients including 115 adult males and 109 adult females were treated at University Medical Center HCMC from November 2020 to October 2021. Among them, 74 (33%) patients were determined to have positive sputum or BAL culture.
Results: Gram-negative bacteria accounted for the majority (52.7%) compared to gram-positive bacteria (47.3%).
The most common strains was K pneumoniae (33.7%), next was S pneumoniae (27%), P aeruginosae (20%), Staphylococcus spp.
S pneumoniae was high resistant to Penicillin và Clindamycin.
was not resistant to Vancomycin.
Study on serum NT-proBNP levels and association with severity of coronary artery disease assessed by SYNTAX II score in patients with acute myocardial infarction
Deciding initial treatment for elderly leukemia patients (≥60 years of age) require determination of a few prognosis factors, such as age, cytogenetic and molecular genetic abnormalities, performance status and comorbidities.
Decitabine is a new drug which being widely used as a therapeutic option for elderly acute myeloid leukemia patients.
Objective: evaluate the efficacy of Decitabine as a monotherapy in elderly patients with acute myeloid leukemia.
Materials and methods: Prospective intervention study without control group. 40 AML patients in NIHBT were enrolled and treated with Decitabine monotherapy from 2019 to 2021.
Results and conclusions: overall response rate was 32.5%, 17.5% achieved complete remission, 5% achieved partial remission and 10% had hematologic improvements.
Related factors associate with treatment access for hepatitis C virus positive patients Hai Duong hospital for tropical diseases in 2021
To evaluate serum NT-proBNP levels and to investigate the relationship between NT-proBNP and SYNTAX II score, which is a measure of the complexity of coronary artery disease in patients with acute myocardial infarction (MI).
Conclusion: The serum NT-proBNP levels of patients with acute MI were quite strongly correlated with severity of coronary lesions assessed by SYNTAX II score.
Materials and methods: The descriptive cross-sectional study on 69 patients with acute MI, who underwent coronary angiographic examination in Heart Center, Military Hospital 103 from January 2020 to June 2021.
Results: The average age was 65.8 ± 11.2 years, male accounted for 76.8%.
Medium NT-proBNP levels in the group with 2-vessel lesions (310.9 pg / ml) and 3-vessel lesions (746.1 pg / ml) was significantly higher than in the group with 1-vessel lesion (89.2 pg / ml) (p<0.05).
Medium NT-proBNP levels in the group with SYNTAX score < 23 (214.8 pg / ml) was significantly lower than in the group with SYNTAX score ≥ 23 (1124.7 pg / ml) (p <0.05).
SYNTAX score was positively correlated with serum NT-proBNP levels (r=0.62; p<0.05).
The cut-off value of NT-proBNP concentration to predict SYNTAX score ≥ 23 was 496.85 pg / ml, sensitivity 75%, specificity 77.4% (p<0.05).
Assessment of early rehabilitation in patient after hemiarthroplasty due to trauma
In a study of 196 patients infected with the hepatitis C virus by means of the cross-sectional descriptive method at Hai Duong Hospital for Tropical Diseases in 2021, we obtained the following results: There is a relationship between access to HCV treatment with high school education or higher (OR= 2.65); Patients with average family background or higher (OR= 2.27); Patients with clinical manifestations (OR=6.30); The group with increased ALT; In patients with cirrhosis (F3, F4), the difference was statistically significant with p<0.05.
The clinical epidemiology characteristics of cardiac arrest in children at the National children's hospital
Results: The early rehabilitation group improved better than control group in term of hip function and Harris score with p <0.05 at 1 week after surgery.
Conclusion: Early rehabilitation in patients after hemiathroplasty surgery due to trauma help patients achieve hip function and reduce postoperative complications.
The histopathological classification of cervical carcinoma at National hospital of Obstetrics and Gynecology
Study to determining the rate of cervical carcinoma's histopathological types at the National hospital of Obstetrics and Gynecology according to the classification of the World Health Organization in 2014.
The cross-sectional method was performed with 200 patients of cevical invasive carcinomas histopathologically diagnosed at National hospital of Obstetrics and Gynecology from January 2017 to December 2018.
The results show most case diagnosed as invasive cervical cancer was at the 40 - 49 age group (32.5%).
Squamous cell carcinoma was the most common at 60.5%, adenocarcinoma, adenosquamous carcinoma, undifferentiated carcinoma and small cell carcinoma accounted for 29.5%; 8%; 1% and 1%.
Conclusions: Invasive cervical cancer was popularly diagnosed at the 40 - 49 age group.
Squamous cell carcinoma had high rate in which non-keratinizing carcinoma was the most popular.
ASsessment of effects of electroacupuncture at'giap tich L1 to L5' points, and'accupoint formula 8' combined with acupressure massage
To describe the clinical epidemiology characteristics of cardiac arrest in children at the National children's hospital from June 2018 to June 2019.
Methods: A cross-sectional study on 102 children with confirmed cardiac arrest.
Results: The group under 1 year old was the most common group (43.1%).
Cardiac arrest mainly in the emergency department and intensive care unit (accounting for 49.0% and 43.1% respectively).
The rate of in-hospital cardiac arrest was higher than that of out-of-hospital (68.6% vs 31.4%).
Cardiovascular causes account for the highest rate (22.6%), followed by infectious diseases (20.6%) and respiratory diseases (17.7%).
Conclusion: Cardiac arrest is common in thegroup of less than 1 year old and mainly occurs in the emergency department and intensive care unit.
Cardiovascular, infectious, and respiratory diseases are common causes of cardiac arrest.
Clinical and laboratory characteristics of cancer patients outside the hematopoietic system treated at the National Institute of Hematology and Blood Transfusion in 2020-2021
Low back pain arising from lumbar spondylosis is a common musculoskeletal disease and patients with this disease tend to rejuvenate over time.
Our study was designed to evaluate the pain degree and motor function improvement effects of the lumbar spine by electroacupuncture at 'Giap Tich L1 to L5' points, and' accupoint formula 8', combined with acupressure massage.
Participants in the study will receive a 14-day course of treatment.
Our study applied method of clinical trials, comparing results before and after treatment.
From September 2021 to September 2022, 50 patients with low back pain stem from spinal degeneration, treated at the Traditional Medicine Hospital of the Ministry of Public Security approved to participate in the study.
The results showed that after treatment, the pain grade according to the VAS scale of the studied patients decreased statistically significantly from 5.94 ± 1.35 (points) to 1.50 ± 1.33 (points), the range of motion of the lumbar spine also increased significantly compared to before treatment.
The above results show that the accupoint formula is significantly effective and should be applied in clinical practice.
Magnetic resonance imaging features of sacral and coccyx myelomeningocele in children
Describe the clinical and laboratory characteristics and conditions of nonhematologic cancer patients in the National Institute of Hematology and Blood Transfusion.
16.1% of patients had DIC status, 70.8% of DIC patients had bone marrow metastases.
54.7% of patients have increased iron stores, 26.7% of patients have iron deficiency.
Subjects and methods: cross-sectional descriptive study, 161 non-hematologic cancer patients in the National Institute of Hematology and Blood Transfusion from 2020 to 2021.
Results and conclusions: 161 patients were found in most of the cancer groups, of which the most common were colorectal cancer (19.3%), stomach cancer (18.6%), thyroid cancer (16.8%).
Common clinical symptoms are anemia (84.5%), hemorrhage (31.1%), infection (20.5%).
Anemia was mainly moderate (26.7%) and severe (31.1%).
The major features of anemia were microcytic and normocytic with 44.1% and 44.9% respectively.
50.3% thrombocytopenia, 14.9% thrombocytosis.
28% leukopenia, 8.6% leukocytosis; Thrombocytosis and leukocytosis were most common in gastric cancer, colorectal cancer, and broncho-pulmonary cancer.
Normal hematopoietic bone marrow 57.3%, bone marrow metastases 17.9%, myeloproliferative disorders 12%, marrow hypoplasia 12.8%.
Characteristics of elevated osmolar pressure in patients with acute ethanol and methanol poisonings
Describe magnetic resonance imaging (MRI) of sacral and coccyx myelomeningocele in children.
Method: A cross-sectional descriptive study, including 32 patients diagnosed and treated for sacral and coccyx myelomeningocele at the Neurological Center - National Children's Hospital, during 1 year (from July 1, 2020 to June 30, 2021).
Results: 32 patients with mean age at admission was 10.4 ± 14.2 months, more boys were infected than girls (the male / female ratio was 1.46/1).
MRI of sacral and coccyx showed that the rate of herniated mass in the sacral region was 59.4%, and the coccyx region was 40.6%.
The average length of the herniated mass was 2.2 ±1.0 cm.
The average width of the herniated mass was 2.3±1.4 cm.
The composition of the herniated mass: 100% contains fluid, 87.5% contains marrow, 46.9% contains fat, 40.6% contains nerve roots and 37.5% contains fibrous.
Distribution of myelomeningocele type: 46.9% lipomyelomeningocele; 40.6% myelomeningocele and 12.5% meningocele.
Conclusion: Spine MRI is the most accurate imaging method in diagnosing sacral and coccyx myelomeningocele in children: determining the location, size and composition of the herniated mass to help the doctors to have prognosis and the best plans for treatment.
Clinical case of renal infarction at Vinmec Phu Quoc international
to assess the characteristics of osmotic pressure increased in patients with acute ethanol and methanol poisonings.
Subjects and methods: A prospective observational study on 121 acute ethanol and methanol poisoned patients with elevated osmolar pressure treated at the Poison Control Center, Bach Mai Hospital was conducted from 7/2019 to 7/2020.
Results: Ethanol and methanol poisonings caused an increase in osmotic pressure; 54.4% of ethanol poisonings and 72.3% of methanol poisonings had severe increases in OG.