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i m a celebrity get me out of here winners list
confirmed that Holly Willoughby will replace McPartlin as co-presenter alongside Declan Donnelly. The lineup was confirmed on 12 November. Note for "Average rating": Since 2010 incl. HD viewers and since 2011 incl. "ITV +1" consumers. A companion show, I'm a Celebrity: Extra Camp (previously I'm a Celebrity...Get Me Out of Here! NOW! from 2002–2015) is broadcast on ITV2 following every episode. It has been shown since the first series in 2002 and has featured a variety of presenters. The show is currently presented by Scarlett Moffatt, Joel Dommett and Joe Swash. I'm a Celebrity...Get Me Out of Here! (UK TV
the show its highest rating since the third series in 2004. The show finished on 9 December 2018 and was won by Harry Redknapp. The first teaser trailer was released on 27 October 2018. The line-up was confirmed on 12 November 2018. The contestants take part in daily trials to earn food. These trials aim to test both physical and mental abilities. The winner is usually determined by the number of stars collected during the trial, with each star representing a meal earned by the winning contestant for their camp mates. Members from camp will take part in the challenge
eng_Latn
3,110,953
who is the winner of survivor season 34
Survivor: Game Changers Survivor: Game Changers — Mamanuca Islands is the 34th season of the American CBS competitive reality television series "Survivor", featuring 20 returning castaways. The season premiered on March 8, 2017 with a two-hour airing, marking the series' 500th episode, and ended on May 24, 2017, when Sarah Lacina was named the winner over Brad Culpepper and Troy "Troyzan" Robertson in a 7–3–0 vote. This season was the third to film in Fiji after "" and "". It was the fourth season to feature entirely returning players, following "", "", and "" and was the 11th season overall
Sandra Diaz-Twine Sandra Diaz-Twine (born July 30, 1974) is an American television personality who became known for her appearances on the reality game show "Survivor". She won the first two seasons she appeared on, "" and "", making her the show's only two-time winner. She returned for Survivor's 34th season, "", where she placed 15th. She was born in Stamford, Connecticut and currently lives with her husband and two children. while working as a secretary for a law firm in Fayetteville, North Carolina. Diaz-Twine seemed like an early target for her lack of physical strength and inability to swim, but
eng_Latn
3,110,954
when does im a celebrity aus 2018 start
rates. On 1 August 2016 the series was renewed for a third season with Morris and Brown returning as hosts, which premiered on 29 January 2017. A fourth season commenced on 28 January 2018 and concluded 12 March 2018. A fifth season has been announced and will air from 13 January 2019. The show is set to be reduced from airing over a six week period to four weeks for the 2019 season. The premise of the show is that there is a group of well known personalities living together in a specially constructed camp site in a jungle. During
the show its highest rating since the third series in 2004. The show finished on 9 December 2018 and was won by Harry Redknapp. The first teaser trailer was released on 27 October 2018. The line-up was confirmed on 12 November 2018. The contestants take part in daily trials to earn food. These trials aim to test both physical and mental abilities. The winner is usually determined by the number of stars collected during the trial, with each star representing a meal earned by the winning contestant for their camp mates. Members from camp will take part in the challenge
eng_Latn
3,110,955
who presented the first i 'm a celebrity
million viewers. I'm a Celebrity...Get Me Out of Here! (UK series 1) The first series of 'I'm a Celebrity...Get Me Out of Here!' was broadcast on ITV from 25 August to 8 September 2002. Ant & Dec presented the main show on ITV, whilst Louise Loughman hosted the spin-off show "I'm a Celebrity...Get Me Out of Here! NOW!" on ITV2. The winner of this series was radio DJ Tony Blackburn. The show began with 8 celebrity contestants. The contestants take part in daily trials to earn food All ratings are taken from the UK Programme Ratings website, BARB. Series average
stay, with the final episode's votes nominating who wins a series and become crowned as "Jungle King/Queen". The programme's first series debuted on 25 August 2002, and was produced by both LWT and Granada Television, and filmed within Tully, Queensland. Later series were undertaken by ITV Studios, and filmed around Murwillumbah, New South Wales. Celebrities participating on the programme receive a donation from ITV to a charity they nominate, with the money raised from charges on voting via text, phone or interactive services. Each series is hosted by Anthony McPartlin and Declan Donnelly, with the exception of the eighteenth series,
eng_Latn
3,110,956
who got eliminated in rising star on 25 march 2018
of the episode, the contestant who sits on the Red Sofa gets eliminated. Wild Card Twist: Some of the eliminated contestants were brought back for another chance. Raenit Singh, Aman Biswal & Chetan Brijvasi. The Top 12 contestants compete in this round. As the round progresses, the contestant who receives less votes at that point of the competition moves to the Red Sofa. At the end of the episode, the contestant who sits on the Red Sofa gets eliminated. WILD CARD Top 12 The Top 10 contestants compete in this round. As the round progresses, the contestant who receives less
Saleem, Neha Bhasin, Akriti Kakar & Jubin Nautiyal. Finalist Maithili Thakur gave a guest performance along with Jubin Nautiyal and sang the song Bawra Mann. Takkar The two bottom scorers of the episode participate in a face-off round. In this round, the collective judges score of 21% will be given to only one contestant who, according to them, performed better. Episode 24: 23 April 2017 The top 3 finalists Maithili Thakur, Bannet Dosanjh and Ankita Kundu compete in the first round. Each expert has 1% vote each as opposed to 7%. The top 2 contestants proeed to the Face-off round.
eng_Latn
3,110,957
who got voted off of survivor on may 10th
this season's cast, but she was cut by producers at the last moment. Her spot was given to Michaela Bradshaw. "" winner Natalie Anderson was originally cast on the season as well, but she ultimately had to back out shortly before filming began due to medical reasons. Her spot on the cast was filled on short notice by "Worlds Apart" contestant Sierra Dawn Thomas. Jonathan Penner from "", "" and "" was considered, but he was cut from the final cast, and Earl Cole, winner of "" was also offered a spot, but he declined. With their appearance in this
to cement his control, causing Mogo Mogo to continually lose challenges and approach the merge in the minority. Two players voluntarily left the game. Jenna Morasca, fearing for her mother's health, decided to drop out on Day 9 and return to her mother's side; her mother would die eight days later from cancer. Sue Hawk also left, distraught after an incident during an immunity challenge in which a naked Richard Hatch had brief but inappropriate bodily contact with her. With ten players remaining, a tribal switch was held where players drew new buffs out of a bag. In an unorthodox
eng_Latn
3,110,958
when did im a celebrity get me out of here start
stay, with the final episode's votes nominating who wins a series and become crowned as "Jungle King/Queen". The programme's first series debuted on 25 August 2002, and was produced by both LWT and Granada Television, and filmed within Tully, Queensland. Later series were undertaken by ITV Studios, and filmed around Murwillumbah, New South Wales. Celebrities participating on the programme receive a donation from ITV to a charity they nominate, with the money raised from charges on voting via text, phone or interactive services. Each series is hosted by Anthony McPartlin and Declan Donnelly, with the exception of the eighteenth series,
had been influenced by the website Hot or Not. YouTube began as a venture capital-funded technology startup, primarily from an $11.5 million investment by Sequoia Capital and an $8 million investment from Artis Capital Management between November 2005 and April 2006. YouTube's early headquarters were situated above a pizzeria and Japanese restaurant in San Mateo, California. The domain name codice_1 was activated on February 14, 2005, and the website was developed over the subsequent months. The first YouTube video, titled "Me at the zoo", shows co-founder Jawed Karim at the San Diego Zoo. The video was uploaded on April 23,
eng_Latn
3,110,959
who has presented i 'm a celebrity get me outta here now
confirmed that Holly Willoughby will replace McPartlin as co-presenter alongside Declan Donnelly. The lineup was confirmed on 12 November. Note for "Average rating": Since 2010 incl. HD viewers and since 2011 incl. "ITV +1" consumers. A companion show, I'm a Celebrity: Extra Camp (previously I'm a Celebrity...Get Me Out of Here! NOW! from 2002–2015) is broadcast on ITV2 following every episode. It has been shown since the first series in 2002 and has featured a variety of presenters. The show is currently presented by Scarlett Moffatt, Joel Dommett and Joe Swash. I'm a Celebrity...Get Me Out of Here! (UK TV
I'm a Celebrity...Get Me Out of Here! (UK series 17) "I'm a Celebrity...Get Me Out of Here!" returned for its seventeenth series on 19 November 2017 on ITV. The series is the third in a three-year contract, as confirmed by Ant & Dec at the end of the Coming Out show in December 2016. In October 2017, it was confirmed that Ant & Dec will return to host the series, despite rumours suggesting that the pair would not be present due to Ant's admittance to rehab earlier in the year for drugs and alcohol addiction. "Made in Chelsea" star Georgia
eng_Latn
3,110,960
who got voted off of survivor april 11 2018
split into two tribes containing ten members each: Takali ("Gen X") and Vanua ("Millennials"). The tribe names come from the Fijian words for "open ocean" and "homeland", respectively. Michaela Bradshaw and Zeke Smith returned the following season for "". David Wright will return in Survivor's 38th season, "Edge of Extinction". The 20 new castaways were initially divided into tribes based on generation. The Gen X tribe was fractured between two alliances—one led by Paul and Chris, and the other by David and Ken—while the Millennial tribe's majority was run by Jay and Michelle. With 16 players remaining, the castaways were
to cement his control, causing Mogo Mogo to continually lose challenges and approach the merge in the minority. Two players voluntarily left the game. Jenna Morasca, fearing for her mother's health, decided to drop out on Day 9 and return to her mother's side; her mother would die eight days later from cancer. Sue Hawk also left, distraught after an incident during an immunity challenge in which a naked Richard Hatch had brief but inappropriate bodily contact with her. With ten players remaining, a tribal switch was held where players drew new buffs out of a bag. In an unorthodox
eng_Latn
3,110,961
who is the winner in rising star season 2
live via the television channel's mobile app. The show premiered on 20 January 2018 on Colors TV. This is the first reality television show in India which involves Live Audience Voting through Voot App. Popular playback singer and music director Shankar Mahadevan, playback singer and actor Monali Thakur and actor-singer Diljit Dosanjh return as the experts in the show. The show is hosted by TV Actor Ravi Dubey. The winner of Rising Star Season 2 is Hemant Brijwasi. In contrast to other singing competition TV shows which feature a cast of celebrity judges, "Rising Star" features a cast of celebrity
of the episode, the contestant who sits on the Red Sofa gets eliminated. Wild Card Twist: Some of the eliminated contestants were brought back for another chance. Raenit Singh, Aman Biswal & Chetan Brijvasi. The Top 12 contestants compete in this round. As the round progresses, the contestant who receives less votes at that point of the competition moves to the Red Sofa. At the end of the episode, the contestant who sits on the Red Sofa gets eliminated. WILD CARD Top 12 The Top 10 contestants compete in this round. As the round progresses, the contestant who receives less
eng_Latn
3,110,962
who did peter kay sing with on the late late show
Peter Andre Peter Andre (born Peter James Andrea, 27 February 1973) is an English-Australian singer, songwriter, businessman, presenter, television personality and actor. He gained popularity as a singer, best known for his singles "Mysterious Girl" and "Flava". He is also known for appearing on the third series of "I'm a Celebrity...Get Me Out of Here!", and the thirteenth series of "Strictly Come Dancing", in which he was partnered with Janette Manrara. During his time on "I'm A Celebrity", Andre developed an on-screen romantic relationship with fellow contestant Katie Price. Andre and Price got married two years after the show's finale;
the top spot for seven weeks and was the best-selling song of 2005 in the UK. In 2008, he co-wrote and starred in "Britain's Got the Pop Factor... and Possibly a New Celebrity Jesus Christ Soapstar Superstar Strictly on Ice", a parody of several British reality television shows. As the series' fictional protagonist Geraldine McQueen, he released the single "The Winner's Song", which reached #2 in the UK singles chart. His 2010–11 stand-up comedy tour was officially inaugurated into the "Guinness World Records" as the most successful of all time, playing to over 1.2 million people. He co-wrote and starred
eng_Latn
3,110,963
when was i 'm a celeb first aired
stay, with the final episode's votes nominating who wins a series and become crowned as "Jungle King/Queen". The programme's first series debuted on 25 August 2002, and was produced by both LWT and Granada Television, and filmed within Tully, Queensland. Later series were undertaken by ITV Studios, and filmed around Murwillumbah, New South Wales. Celebrities participating on the programme receive a donation from ITV to a charity they nominate, with the money raised from charges on voting via text, phone or interactive services. Each series is hosted by Anthony McPartlin and Declan Donnelly, with the exception of the eighteenth series,
million viewers. I'm a Celebrity...Get Me Out of Here! (UK series 1) The first series of 'I'm a Celebrity...Get Me Out of Here!' was broadcast on ITV from 25 August to 8 September 2002. Ant & Dec presented the main show on ITV, whilst Louise Loughman hosted the spin-off show "I'm a Celebrity...Get Me Out of Here! NOW!" on ITV2. The winner of this series was radio DJ Tony Blackburn. The show began with 8 celebrity contestants. The contestants take part in daily trials to earn food All ratings are taken from the UK Programme Ratings website, BARB. Series average
eng_Latn
3,110,964
who won i m a celebrity in 2006
programme ran on weekdays on ITV1. It was hosted by Series 5 contestant Sheree Murphy and Phillip Schofield. The series was won by Matt Willis on Day 19. Iceland, the supermarket, replaced First Choice Holidays as the shows' sponsor. On Day 8, the camp was split in two for the first time in I'm A Celebrity history and took part in a 'Battle of The Sexes' like competition. Team Base Camp consisted of David, Dean, Jason, Matt, Scott and Toby. Team Snake Rock consisted of Faith, Jan, Lauren, Malandra, Myleene and Phina. The two teams competed in Bushtucker Trials for
trial each today, to win a fully prepared three course meal for dinner. Fran Cosgrave contested in 'Eel Helmet' for the starter course. Paul Burrell contested in 'Bushtucker Bonanza' for the main course and Joe Pasquale contested in 'Danger Down Under' for the dessert course. Each of them won the maximum of 5 stars. Day 18 Joe Pasquale was crowned 'King of the Jungle' in the final vote. Paul Burrell was second and Fran Cosgrave was third. Natalie Appleton was initially selected to take part in this trial, but walked out before this and was replaced by Shelia Ferguson. All
eng_Latn
3,110,965
who was the winner of the first uk series of im a celebrity
million viewers. I'm a Celebrity...Get Me Out of Here! (UK series 1) The first series of 'I'm a Celebrity...Get Me Out of Here!' was broadcast on ITV from 25 August to 8 September 2002. Ant & Dec presented the main show on ITV, whilst Louise Loughman hosted the spin-off show "I'm a Celebrity...Get Me Out of Here! NOW!" on ITV2. The winner of this series was radio DJ Tony Blackburn. The show began with 8 celebrity contestants. The contestants take part in daily trials to earn food All ratings are taken from the UK Programme Ratings website, BARB. Series average
Nancy Wilkinson Nancy Wilkinson (29 September 1919 – 21 November 1999) was the winner of the first BBC TV Mastermind quiz series in 1972. Nancy Wilkinson was born Nancy Barbara Constance Bird in London in 1919. She studied modern languages and music at Cambridge from 1937 to 1941, and during World War II worked for the intelligence service at Bletchley Park. On 13 July 1945 she married John Wilkinson, and after some years in Cornwall they lived in Kingston, Cambridgeshire, for the rest of her life. She taught at the Cambridgeshire College of Arts and Technology (now the Anglia Ruskin
eng_Latn
3,110,966
who won the first i 'm a celebrity get me out of here
I'm a Celebrity...Get Me Out of Here! (UK series 1) The first series of 'I'm a Celebrity...Get Me Out of Here!' was broadcast on ITV from 25 August to 8 September 2002. Ant & Dec presented the main show on ITV, whilst Louise Loughman hosted the spin-off show "I'm a Celebrity...Get Me Out of Here! NOW!" on ITV2. The winner of this series was radio DJ Tony Blackburn. The show began with 8 celebrity contestants. The contestants take part in daily trials to earn food All ratings are taken from the UK Programme Ratings website, BARB. Series average = 7.57
NBC announced that there would not be a third season. The first season had 10 contestants. It aired nightly from February 19, 2003 to March 5, 2003 on ABC. John Lehr was the host from the Australian outback. The time differential created serious issues with the live feed. NBC picked up the former ABC show. It aired for 14 episodes and followed the UK's format. The series premiered with a two-hour episode 8–10 pm EDT on June 1, 2009. It aired with a two-hour episode every Monday 8–10 pm aired 8–9 pm EDT Tuesday through Thursday until its June 24
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3,110,967
who got voted out on survivor may 2 2018
to cement his control, causing Mogo Mogo to continually lose challenges and approach the merge in the minority. Two players voluntarily left the game. Jenna Morasca, fearing for her mother's health, decided to drop out on Day 9 and return to her mother's side; her mother would die eight days later from cancer. Sue Hawk also left, distraught after an incident during an immunity challenge in which a naked Richard Hatch had brief but inappropriate bodily contact with her. With ten players remaining, a tribal switch was held where players drew new buffs out of a bag. In an unorthodox
this season's cast, but she was cut by producers at the last moment. Her spot was given to Michaela Bradshaw. "" winner Natalie Anderson was originally cast on the season as well, but she ultimately had to back out shortly before filming began due to medical reasons. Her spot on the cast was filled on short notice by "Worlds Apart" contestant Sierra Dawn Thomas. Jonathan Penner from "", "" and "" was considered, but he was cut from the final cast, and Earl Cole, winner of "" was also offered a spot, but he declined. With their appearance in this
eng_Latn
3,110,968
the liquid that collects in the cavity of the glomerular ( bowman 's ) capsule is
Bowman's capsule Bowman's capsule (or the Bowman capsule, capsula glomeruli, or glomerular capsule) is a cup-like sack at the beginning of the tubular component of a nephron in the mammalian kidney that performs the first step in the filtration of blood to form urine. A glomerulus is enclosed in the sac. Fluids from blood in the glomerulus are collected in the Bowman's capsule (i.e., glomerular filtrate) and further processed along the nephron to form urine. This process is known as ultrafiltration.The Bowman's capsule is named after Sir William Bowman, who identified it in 1842. Outside the capsule, there are two
Glomerulus (kidney) The glomerulus (), plural glomeruli, is a network of capillaries known as a "tuft", located at the beginning of a nephron in the kidney. The tuft is structurally supported by intraglomerular mesangial cells. The blood is filtered across the capillary walls of this tuft through the glomerular filtration barrier, which yields its filtrate of water and soluble substances to a cup-like sac known as Bowman's capsule. The filtrate then enters the renal tubule, of the nephron. The glomerulus receives its blood supply from an afferent arteriole of the renal arterial circulation. Unlike most capillary beds, the glomerular capillaries
eng_Latn
3,110,969
what condition is associated with the feeling of incomplete evacuation of the bowel
Rectal tenesmus Rectal tenesmus (, from Greek , from to stretch, strain) is a feeling of incomplete defecation. It is the sensation of inability or difficulty to empty the bowel at defecation, even if the bowel contents have already been evacuated. Tenesmus indicates the feeling of a residue, and is not always correlated with the actual presence of residual fecal matter in the rectum. It is frequently painful and may be accompanied by involuntary straining and other gastrointestinal symptoms. Tenesmus has both a nociceptive and a neuropathic component. Vesical tenesmus is a similar condition, experienced as a feeling of incomplete
help relieve anxiety and apprehension. Abdominal distension Abdominal distension occurs when substances, such as air (gas) or fluid, accumulate in the abdomen causing its expansion. It is typically a symptom of an underlying disease or dysfunction in the body, rather than an illness in its own right. People suffering from this condition often describe it as "feeling bloated". Sufferers often experience a sensation of fullness, abdominal pressure and possibly nausea, pain or cramping. In the most extreme cases, upward pressure on the diaphragm and lungs can also cause shortness of breath. Through a variety of causes (see below), bloating is
eng_Latn
3,110,970
what are the symptoms of a systemic anaphylactic reaction
term comes from the Greek words ἀνά, "ana", meaning "against", and φύλαξις, "phylaxis", meaning "protection". There are ongoing efforts to develop sublingual epinephrine to treat anaphylaxis. Subcutaneous injection of the anti-IgE antibody omalizumab is being studied as a method of preventing recurrence, but it is not yet recommended. Anaphylaxis Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death. It typically causes more than one of the following: an itchy rash, throat or tongue swelling, shortness of breath, vomiting, lightheadedness, and low blood pressure. These symptoms typically come on over minutes to hours. Common causes
Drug reaction with eosinophilia and systemic symptoms Drug reaction with eosinophilia and systemic symptoms (DRESS syndrome), also termed drug-induced hypersensitivity syndrome (DIHS), is a rare reaction to certain medications. It involves primarily a widespread skin rash, fever, lymphadenopathy, and characteristic hematologic abnormalities such as eosinophilia, thrombocytopenia, and atypical lymphocytosis. However, it is often complicated by potentially life-threatening inflammation of internal organs: the syndrome has about a 10% mortality. Treatment consists of stopping the offending medication and providing supportive care. Systemic steroids are commonly used as well but no controlled clinical trials assess the efficacy of this treatment. DRESS syndrome is
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3,110,971
is vitamin b12 deficiency the same as pernicious anemia
Vitamin B12 deficiency anemia Vitamin B deficiency anemia, of which pernicious anemia is a type, is a disease in which not enough red blood cells are produced due to a deficiency of vitamin B. The most common initial symptom is feeling tired. Other symptoms may include shortness of breath, pale skin, chest pain, numbness in the hands and feet, poor balance, a smooth red tongue, poor reflexes, depression and confusion. Without treatment some of these problems may become permanent. Pernicious anemia refers to anemia that results from lack of intrinsic factor. Lack of intrinsic factor is most commonly due to
Vitamin B12 deficiency Vitamin B deficiency, also known as cobalamin deficiency, is the medical condition of low blood levels of vitamin B. In mild deficiency a person may feel tired and have a reduced number of red blood cells (anemia). In moderate deficiency there may be inflammation of the tongue and the beginning of neurological problems including abnormal sensations such as "pins and needles", while severe deficiency may include reduced heart function and greater neurological problems. Neurological problems may include changes in reflexes, poor muscle function, memory problems, decreased taste, and in extreme cases psychosis. Sometimes temporary infertility may also
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3,110,972
why does carbon dioxide increase in the body
Hypercapnia is generally caused by hypoventilation, lung disease, or diminished consciousness. It may also be caused by exposure to environments containing abnormally high concentrations of carbon dioxide, such as from volcanic or geothermal activity, or by rebreathing exhaled carbon dioxide. It can also be an initial effect of administering supplemental oxygen on a patient with sleep apnea. In this situation the hypercapnia can also be accompanied by respiratory acidosis. Hypercapnia is generally defined as a blood gas carbon dioxide level over 45 mmHg. Since carbon dioxide is in equilibrium with carbonic acid in the blood, hypercapnia can drive serum pH
Hypercapnia Hypercapnia, also known as hypercarbia and CO retention, is a condition of abnormally elevated carbon dioxide (CO) levels in the blood. Carbon dioxide is a gaseous product of the body's metabolism and is normally expelled through the lungs. Hypercapnia normally triggers a reflex which increases breathing and access to oxygen (O), such as arousal and turning the head during sleep. A failure of this reflex can be fatal, for example as a contributory factor in sudden infant death syndrome. Hypercapnia is the opposite of hypocapnia, the state of having abnormally reduced levels of carbon dioxide in the blood. Hypercapnia
eng_Latn
3,110,973
a medical term that means decrease in blood pressure is
is a medical concern if it causes signs or symptoms, such as dizziness, fainting, or in extreme cases, shock. When arterial pressure and blood flow decrease beyond a certain point, the perfusion of the brain becomes critically decreased (i.e., the blood supply is not sufficient), causing lightheadedness, dizziness, weakness or fainting. Sometimes the arterial pressure drops significantly when a patient stands up from sitting. This is known as orthostatic hypotension (postural hypotension); gravity reduces the rate of blood return from the body veins below the heart back to the heart, thus reducing stroke volume and cardiac output. When people are
Hypovolemia Hypovolemia is a state of decreased blood volume; more specifically, decrease in volume of blood plasma. It is thus the intravascular component of volume contraction (or loss of blood volume due to things such as bleeding or dehydration), but, as it also is the most essential one, "hypovolemia" and volume contraction are sometimes used synonymously. Hypovolemia is characterized by sodium depletion, and thus is distinct from (although often overlapping with) dehydration, excessive loss of body water. Common causes of hypovolemia are: Symptoms may not be present until 10–20% of total whole-blood volume is lost. Headache, fatigue, nausea, profuse sweating,
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3,110,974
test used to identify the presence of fibrinolysis
of fibrinogen to fibrin. This effect can be seen in the thrombin clotting time (TCT) test, which is prolonged in a person that has active fibrinolysis. FDPs, and a specific FDP, the D-dimer, can be measured using antibody-antigen technology. This is more specific than the TCT, and confirms that fibrinolysis has occurred. It is therefore used to indicate deep-vein thrombosis, pulmonary embolism, DIC and efficacy of treatment in acute myocardial infarction. Alternatively, a more rapid detection of fibrinolytic activity, especially hyperfibrinolysis, is possible with thromboelastometry (TEM) in whole blood, even in patients on heparin. In this assay, increased fibrinolysis is
enough. The fibrinolytic system is closely linked to control of inflammation, and plays a role in disease states associated with inflammation. Plasmin, in addition to lysing fibrin clots, also cleaves the complement system component C3, and fibrin degradation products have some vascular permeability inducing effects. In a process called thrombolysis (the breakdown of a thrombus), fibrinolytic drugs are used. They are given following a heart attack to dissolve the thrombus blocking the coronary artery; experimentally after a stroke to allow blood flow back to the affected part of the brain; and in the event of a massive pulmonary embolism. Thrombolysis
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3,110,975
what happens to blood pressure in anaphylactic shock
limited use if the cause is food or if the person has a normal blood pressure, and they are not specific for the diagnosis. There are three main classifications of anaphylaxis. Anaphylactic shock is associated with systemic vasodilation that causes low blood pressure which is by definition 30% lower than the person's baseline or below standard values. Biphasic anaphylaxis is the recurrence of symptoms within 1–72 hours with no further exposure to the allergen. Reports of incidence vary, with some studies claiming as many as 20% of cases. The recurrence typically occurs within 8 hours. It is managed in the
Hyperventilation Hyperventilation (a.k.a. overbreathing) occurs when the rate or tidal volume of breathing eliminates more carbon dioxide than the body can produce. This leads to hypocapnia, a reduced concentration of carbon dioxide dissolved in the blood. The body normally attempts to compensate for this homeostatically but if this fails or is overridden, the blood pH will rise, leading to respiratory alkalosis. The symptoms of respiratory alkalosis include: dizziness, tingling in the lips, hands or feet, headache, weakness, fainting and seizures. In extreme cases it may cause carpopedal spasms, a flapping and contraction of the hands and feet. Factors that may
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3,110,976
where is pseudomonas aeruginosa found in the human body
Treatment of "P. aeruginosa" infections can be difficult due to its natural resistance to antibiotics. When more advanced antibiotic drug regimens are needed adverse effects may result. It is citrate, catalase, and oxidase positive. It is found in soil, water, skin flora, and most man-made environments throughout the world. It thrives not only in normal atmospheres, but also in low-oxygen atmospheres, thus has colonized many natural and artificial environments. It uses a wide range of organic material for food; in animals, its versatility enables the organism to infect damaged tissues or those with reduced immunity. The symptoms of such infections
Pseudomonas aeruginosa Pseudomonas aeruginosa is a common Gram-negative, rod-shaped bacterium that can cause disease in plants and animals, including humans. A species of considerable medical importance, "P. aeruginosa" is a multidrug resistant pathogen recognized for its ubiquity, its intrinsically advanced antibiotic resistance mechanisms, and its association with serious illnesses – hospital-acquired infections such as ventilator-associated pneumonia and various sepsis syndromes. The organism is considered opportunistic insofar as serious infection often occurs during existing diseases or conditions – most notably cystic fibrosis and traumatic burns. It generally affects the immunocompromised but can also infect the immunocompetent as in hot tub folliculitis.
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3,110,977
beri beri is a disease caused by the deficiency of
Thiamine deficiency Thiamine deficiency is a medical condition of low levels of thiamine (vitamin B1). A severe and chronic form is known as beriberi. There are two main types in adults: wet beriberi, and dry beriberi. Wet beriberi affects the cardiovascular system resulting in a fast heart rate, shortness of breath, and leg swelling. Dry beriberi affects the nervous system resulting in numbness of the hands and feet, confusion, trouble moving the legs, and pain. A form with loss of appetite and constipation may also occur. Another type, acute beriberi, is found mostly in babies and presents with loss of
couple of weeks. The disease may be prevented at the population level through the fortification of food. Thiamine deficiency is rare in the United States. It remains relatively common in sub-Saharan Africa. Outbreaks have been seen in refugee camps. Thiamine deficiency has been described for thousands of years in Asia and became more common in the late 1800s with the increased processing of rice. Symptoms of beriberi include weight loss, emotional disturbances, impaired sensory perception, weakness and pain in the limbs, and periods of irregular heart rate. Edema (swelling of bodily tissues) is common. It may increase the amount of
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3,110,978
which gas is used in oxygen cylinder in hospital
hospitals and other institutions that need large volumes of pure oxygen gas. Liquid oxygen is passed through heat exchangers, which convert the cryogenic liquid into gas before it enters the building. Oxygen is also stored and shipped in smaller cylinders containing the compressed gas; a form that is useful in certain portable medical applications and oxy-fuel welding and cutting. Uptake of from the air is the essential purpose of respiration, so oxygen supplementation is used in medicine. Treatment not only increases oxygen levels in the patient's blood, but has the secondary effect of decreasing resistance to blood flow in many
surgical equipment. However, this has changed and instrument air is becoming a popular alternative to Nitrogen. As with Nitrogen, pressures range around 1.2 MPa (175 psi). UK systems are supplied at 11 bar to the local area and regulated down to 7-8 bar at point of use. Typically used for insufflation during surgery, and also used in laser surgeries. System pressures are maintained at about 345 kPa (50 psi), UK 4 bar. It is also used for certain respiratory disorders.It contains 5 percent. Medical vacuum in a hospital supports suction equipment and evacuation procedures, supplied by vacuum pump systems exhausting
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3,110,979
what are the two shockable rhythms in cardiac arrest
use molecular autopsy or postmortem molecular testing which uses a set of molecular techniques to find the ion channels that are cardiac defective. Clinicians classify cardiac arrest into "shockable" versus "non–shockable", as determined by the ECG rhythm. This refers to whether a particular class of cardiac dysrhythmia is treatable using defibrillation. The two "shockable" rhythms are ventricular fibrillation and pulseless ventricular tachycardia while the two "non–shockable" rhythms are asystole and pulseless electrical activity. With positive outcomes following cardiac arrest unlikely, an effort has been spent in finding effective strategies to prevent cardiac arrest. With the prime causes of cardiac arrest
Sinus rhythm A sinus rhythm is any cardiac rhythm in which depolarization of the cardiac muscle begins at the sinus node. It is characterised by the presence of correctly oriented P waves on the electrocardiogram (ECG). Sinus rhythm is necessary, but not sufficient, for normal electrical activity within the heart. The term normal sinus rhythm (NSR) is sometimes used to denote a specific type of sinus rhythm where all other measurements on the ECG also fall within designated normal limits, giving rise to the characteristic appearance of the ECG when the electrical conduction system of the heart is functioning normally.
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3,110,980
where is the blood first filtered in a nephron
water from within the nephron and returning it to the venous vasculature when appropriate. Some diseases of the nephron predominantly affect either the glomeruli or the tubules. Glomerular diseases include diabetic nephropathy, glomerulonephritis and IgA nephropathy; renal tubular diseases include acute tubular necrosis and polycystic kidney disease. The nephron is the functional unit of the kidney. Each nephron is composed of a renal corpuscle, the initial filtering component; and a renal tubule that processes and carries away the filtered fluid. The renal corpuscle is the site of the filtration of blood plasma. The renal corpuscle consists of the glomerulus, and
passive: it is dependent on the intracapillary blood pressure. About one-fifth of the plasma is filtered as the blood passes through the glomerular capillaries; four-fifths continues into the peritubular capillaries. Normally the only components of the blood that are not filtered into Bowman's capsule are blood proteins, red blood cells, white blood cells and platelets. Over 150 liters of fluid enter the glomeruli of an adult every day: 99% of the water in that filtrate is reabsorbed. Reabsorption occurs in the renal tubules and is either passive, due to diffusion, or active, due to pumping against a concentration gradient. Secretion
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3,110,981
disease caused due to lack of vitamin b
Thiamine deficiency Thiamine deficiency is a medical condition of low levels of thiamine (vitamin B1). A severe and chronic form is known as beriberi. There are two main types in adults: wet beriberi, and dry beriberi. Wet beriberi affects the cardiovascular system resulting in a fast heart rate, shortness of breath, and leg swelling. Dry beriberi affects the nervous system resulting in numbness of the hands and feet, confusion, trouble moving the legs, and pain. A form with loss of appetite and constipation may also occur. Another type, acute beriberi, is found mostly in babies and presents with loss of
Vitamin B12 deficiency Vitamin B deficiency, also known as cobalamin deficiency, is the medical condition of low blood levels of vitamin B. In mild deficiency a person may feel tired and have a reduced number of red blood cells (anemia). In moderate deficiency there may be inflammation of the tongue and the beginning of neurological problems including abnormal sensations such as "pins and needles", while severe deficiency may include reduced heart function and greater neurological problems. Neurological problems may include changes in reflexes, poor muscle function, memory problems, decreased taste, and in extreme cases psychosis. Sometimes temporary infertility may also
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3,110,982
what causes your anion gap to be high
be high if it is over 12 mEq/L. High anion gap metabolic acidosis is typically caused by acid produced by the body. More rarely, it may be caused by ingesting methanol or overdosing on aspirin. The Delta Ratio is a formula that can be used to assess elevated anion gap metabolic acidosis and to evaluate whether mixed acid base disorder (metabolic acidosis) is present. The list of agents that cause high anion gap metabolic acidosis is similar to but broader than the list of agents that cause a serum osmolal gap. The most common causes of high anion gap metabolic
High anion gap metabolic acidosis High anion gap metabolic acidosis is a form of metabolic acidosis characterized by a high anion gap (a medical value based on the concentrations of ions in a patient's serum). Metabolic acidosis occurs when the body produces too much acid, or when the kidneys are not removing enough acid from the body. Several types of metabolic acidosis occur, grouped by their influence on the anion gap. The anion gap can be increased due to relatively low levels of cations other than sodium and potassium (e.g. calcium or magnesium). An anion gap is usually considered to
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3,110,983
when was fen phen taken off the market
reports of valvular heart disease and pulmonary hypertension, primarily in women who had been undergoing treatment with fen-phen or (dex)fenfluramine, the FDA requested its withdrawal from the market in September 1997. The action was based on findings from doctors who had evaluated people taking these two drugs with echocardiograms, a procedure that can test the functioning of heart valves. The findings indicated that approximately 30 percent of people who had taken the combination up to 24 months had abnormal echocardiograms, even though they had no symptoms. This percentage of abnormal test results was much higher than would be expected from
fenfluramine with primary pulmonary hypertension and dyspnea in a small sample of patients. Fenfluramine was withdrawn from the U.S. market in 1997 after reports of heart valve disease and continued findings of pulmonary hypertension, including a condition known as cardiac fibrosis. It was subsequently withdrawn from other markets around the world. It was banned in India in 1998. Fenfluramine was formerly marketed under the brand names Pondimin, Ponderax, and Adifax, among others. Unlike various other amphetamine derivatives, fenfluramine is reported to be dysphoric, "unpleasantly lethargic", and non-addictive at therapeutic doses. However, it has been reported to be used recreationally at
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3,110,984
acute viral infection of upper and lower respiratory tracts is called
Lower respiratory tract infection Lower respiratory tract infection (LRTI), while often used as a synonym for pneumonia, can also be applied to other types of infection including lung abscess and acute bronchitis. Symptoms include shortness of breath, weakness, fever, coughing and fatigue. There are a number of symptoms that are characteristic of lower respiratory tract infections. The two most common are bronchitis and edema. Influenza affects both the upper and lower respiratory tracts. Antibiotics are the first line treatment for pneumonia; however, they are not effective or indicated for parasitic or viral infections. Acute bronchitis typically resolves on its own
Bronchitis Bronchitis is inflammation of the bronchi (large and medium-sized airways) in the lungs. Symptoms include coughing up mucus, wheezing, shortness of breath, and chest discomfort. Bronchitis is divided into two types: acute and chronic. Acute bronchitis is also known as a chest cold. Acute bronchitis usually has a cough that lasts around three weeks. In more than 90% of cases the cause is a viral infection. These viruses may be spread through the air when people cough or by direct contact. Risk factors include exposure to tobacco smoke, dust, and other air pollution. A small number of cases are
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most common cause of death in burn patients
order of frequency, potential complications include: pneumonia, cellulitis, urinary tract infections and respiratory failure. Risk factors for infection include: burns of more than 30% TBSA, full-thickness burns, extremes of age (young or old), or burns involving the legs or perineum. Pneumonia occurs particularly commonly in those with inhalation injuries. Anemia secondary to full thickness burns of greater than 10% TBSA is common. Electrical burns may lead to compartment syndrome or rhabdomyolysis due to muscle breakdown. Blood clotting in the veins of the legs is estimated to occur in 6 to 25% of people. The hypermetabolic state that may persist for
prognosis is worse in those with larger burns, those who are older, and those who are females. The presence of a smoke inhalation injury, other significant injuries such as long bone fractures, and serious co-morbidities (e.g. heart disease, diabetes, psychiatric illness, and suicidal intent) also influence prognosis. On average, of those admitted to United States burn centers, 4% die, with the outcome for individuals dependent on the extent of the burn injury. For example, admittees with burn areas less than 10% TBSA had a mortality rate of less than 1%, while admittees with over 90% TBSA had a mortality rate
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3,110,986
what is rate of fluid filtered out in bowman 's capsule
"poles": Inside the capsule, the layers are as follows, from outside to inside: The process of filtration of the blood in the Bowman's capsule is ultrafiltration (or glomerular filtration), and the normal rate of filtration is 125 ml/min, equivalent to 80 times the daily blood volume. Any proteins under roughly 30 kilodaltons can pass freely through the membrane, although there is some extra hindrance for negatively charged molecules due to the negative charge of the basement membrane and the podocytes. Any small molecules such as water, glucose, salt (NaCl), amino acids, and urea pass freely into Bowman's space, but cells,
platelets and large proteins do not. As a result, the filtrate leaving the Bowman's capsule is very similar to blood plasma (filtrate or glomerular filtrate is composed of blood plasma minus plasma protein i.e. it contains all the components of blood plasma except the proteins) in composition as it passes into the proximal convoluted tubule. Measuring the glomerular filtration rate (GFR) is a diagnostic test of kidney function. A decreased GFR may be a sign of renal failure. A number of diseases can result in various problems within the glomerulus. Examples include acute proliferative (endocapillary) glomerulonephritis, mesangioproliferative glomerulonephritis, mesangiocapillary (membranoproliferative)
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3,110,987
a key characteristic feature of acute respiratory distress syndrome ( ards ) is
Acute respiratory distress syndrome Acute respiratory distress syndrome (ARDS) is type of respiratory failure characterized by rapid onset of widespread inflammation in the lungs. Symptoms include shortness of breath, rapid breathing, and bluish skin coloration. Among those who survive, a decreased quality of life is relatively common. Causes may include sepsis, pancreatitis, trauma, pneumonia, and aspiration. The underlying mechanism involves diffuse injury to cells which form the barrier of the microscopic air sacs of the lungs, surfactant dysfunction, activation of the immune system, and dysfunction of the body's regulation of blood clotting. In effect, ARDS impairs the lungs' ability to
known as the PALLIC definition. The signs and symptoms of ARDS often begin within two hours of an inciting event, but can occur after 1–3 days. Signs and symptoms may include shortness of breath, fast breathing, and a low oxygen level in the blood due to abnormal ventilation. Diffuse compromise of the pulmonary system resulting in ARDS generally occurs in the setting of critical illness. ARDS may be seen in the setting of severe pulmonary (pneumonia) or systemic infection (sepsis), following trauma, multiple blood transfusions (TRALI), severe burns, severe inflammation of the pancreas (pancreatitis), near-drowning or other aspiration events, drug
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3,110,988
medical term for deficiency of oxygen in the blood
iron atom to its ferric form. This form of inactive hemoglobin is called methemoglobin and can be made by ingesting sodium nitrite as well as certain drugs and other chemicals. Hemoglobin plays a substantial role in carrying oxygen throughout the body, and when it is deficient, anemia can result, causing 'anaemic hypoxia' if tissue perfusion is decreased. Iron deficiency is the most common cause of anemia. As iron is used in the synthesis of hemoglobin, less hemoglobin will be synthesised when there is less iron, due to insufficient intake, or poor absorption. Anemia is typically a chronic process that is
Hypoxemia Hypoxemia (or hypoxaemia in British English) is an abnormally low level of oxygen in the blood. More specifically, it is oxygen deficiency in arterial blood. Hypoxemia has many causes, often respiratory disorders, and can cause tissue hypoxia as the blood is not supplying enough oxygen to the body. "Hypoxemia" refers to low oxygen in the blood, and the more general term "hypoxia" is an abnormally low oxygen content in any tissue or organ, or the body as a whole. Hypoxemia can cause hypoxia (hypoxemic hypoxia), but hypoxia can also occur via other mechanisms, such as anemia. Hypoxemia is usually
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3,110,989
an antiviral drug that is also used in the treatment of parkinson 's disease is
antagonistic properties and is used as an antiparkinsonic drug (i.e., in the treatment of Parkinson's disease). However, in general, neither rimantadine nor amantadine is a preferred agent for this therapy and would be reserved for cases of the disease that are less responsive to front-line treatments. Taking paracetamol (acetaminophen, Tylenol) or acetylsalicylic acid (aspirin) while taking rimantadine is known to reduce the body's uptake of rimantadine by approximately 12%. Cimetidine also affects the body's uptake of rimantadine. Rimantadine can produce gastrointestinal and central nervous system adverse effects. Approximately 6% of patients (compared to 4% of patients taking a placebo) reported
of $500 million to help combat the African AIDS epidemic included nevirapine, among other medications and programs. Nevirapine Nevirapine (NVP), marketed under the trade name Viramune among others, is a medication used to treat and prevent HIV/AIDS, specifically HIV-1. It is generally recommended for use with other antiretroviral medication. It may be used to prevent mother to child spread during birth but is not recommended following other exposures. It is taken by mouth. Common side effects include rash, headache, nausea, feeling tired, and liver problems. The liver problems and skin rash may be severe and should be checked for during
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3,110,990
visual signs of spoilage for fruits and vegetables
the process. While the bacteria itself may or may not be harmful, the waste products may be unpleasant to taste or may even be harmful to one's health. Yeasts can be responsible for the decomposition of food with a high sugar content. The same effect is useful in the production of various types of food and beverages, such as bread, yogurt, cider, and alcoholic beverages. Signs of food spoilage may include an appearance different from the food in its fresh form, such as a change in color, a change in texture, an unpleasant odour, or an undesirable taste. The item
symptoms are severe wasting, leaving little or no edema, minimal subcutaneous fat, severe muscle wasting, and non-normal serum albumin levels. Marasmus can result from a sustained diet of inadequate energy and protein, and the metabolism adapts to prolong survival. It is traditionally seen in famine, significant food restriction, or more severe cases of anorexia. Conditions are characterized by extreme wasting of the muscles and a gaunt expression. Undernutrition encompasses stunted growth (stunting), wasting, and deficiencies of essential vitamins and minerals (collectively referred to as micronutrients). The term hunger, which describes a feeling of discomfort from not eating, has been used
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3,110,991
the signs and symptoms of include dermatitis dementia diarrhea
alcoholism, long-term diarrhea, carcinoid syndrome, Hartnup disease, and a number of medications such as isoniazid. Diagnosis is typically based on symptoms and may be assisted by urine testing. Treatment is with either niacin or nicotinamide supplementation. Improvements typically begin within a couple of days. General improvements in diet are also frequently recommended. Decreasing sun exposure via sunscreen and proper clothing is important while the skin heals. Without treatment death may occur. It occurs most commonly in the developing world, specifically sub-Saharan Africa. The classic symptoms of pellagra are diarrhea, dermatitis, dementia, and death ("the four Ds"). A more comprehensive list
by fungal infection such as Candida albicans causing oral thrush. Pharyngitis may also be caused by mechanical, chemical or thermal irritation, for example cold air or acid reflux. Some medications may produce pharyngitis such as pramipexole and antipsychotics. It is hard to differentiate a viral and a bacterial cause of a sore throat based on symptoms alone. Thus often a throat swab is done to rule out a bacterial cause. The modified Centor criteria may be used to determine the management of people with pharyngitis. Based on 5 clinical criteria, it indicates the probability of a streptococcal infection. One point
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3,110,992
where do filtration secretion and reabsorption take place
This filtrate then flows along the length of the nephron, which is a tubular structure lined by a single layer of specialized cells and surrounded by capillaries. The major functions of these lining cells are the reabsorption of water and small molecules from the filtrate into the blood, and the secretion of wastes from the blood into the urine. Proper function of the kidney requires that it receives and adequately filters blood. This is performed at the microscopic level by many hundreds of thousands of filtration units called renal corpuscles, each of which is composed of a glomerulus and a
to the filtrate in the nephron and aids in the reabsorption of water. Blood is filtered in the glomerulus by solute size. Ions such as sodium, chloride, potassium, and calcium are easily filtered, as is glucose. Proteins are not passed through the glomerular filter because of their large size, and do not appear in the filtrate or urine unless a disease process has affected the glomerular capsule or the proximal and distal convoluted tubules of the nephron. Though the renal medulla only receives a small percentage of the renal blood flow, the oxygen extraction is very high, causing a low
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3,110,993
where does the highest rate of tubular reabsorption occur
Sodium passes along an electrochemical gradient (passive transport) from the lumen into the tubular cell, together with water and chloride which also diffuse passively. Water is reabsorbed to the same degree, resulting in the concentration in the end of the proximal tubule being the same as in the beginning. In other words, the reabsorption in the proximal tubule is isosmotic. Sodium is reabsorbed in the thick ascending limb of loop of Henle, by Na-K-2Cl symporter and Na-H antiporter. It goes against its chemical driving force, but the high electrical driving force renders the overall electrochemical driving force positive anyway, availing
some sodium to diffuse passively either the transcellular or paracellular way.. In the distal convoluted tubule sodium is transported against an electrochemical gradient by sodium-chloride symporters. The principal cells are the sodium-transporting cells in the collecting duct system. Although only a fragment of total reabsorption happens here, it is the main part of intervention. This is e.g. done by endogenous production of aldosterone, increasing reabsorption. Since the normal excretion rate of sodium is ~100mmoles/day, then a regulation of the absorption of still more than 1000 mmoles/day entering the collecting duct system has a substantial influence of the total sodium excreted.
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3,110,994
a medical term which means a deficiency but not a total lack of oxygen
Hypoxia (medical) Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level. Hypoxia may be classified as either "generalized", affecting the whole body, or "local", affecting a region of the body. Although hypoxia is often a pathological condition, variations in arterial oxygen concentrations can be part of the normal physiology, for example, during hypoventilation training or strenuous physical exercise. Hypoxia differs from hypoxemia and anoxemia in that hypoxia refers to a state in which oxygen supply is insufficient, whereas hypoxemia and anoxemia refer specifically to states
Ischemia Ischemia or ischaemia is a restriction in blood supply to tissues, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive). Ischemia is generally caused by problems with blood vessels, with resultant damage to or dysfunction of tissue. It also means local anemia in a given part of a body sometimes resulting from congestion (such as vasoconstriction, thrombosis or embolism). Ischemia comprises not only insufficiency of oxygen, but also reduced availability of nutrients and inadequate removal of metabolic wastes. Ischemia can be partial (poor perfusion) or total. Since oxygen is carried to tissues in
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3,110,995
what two body systems are involved with ph balance
the extracellular fluid, including the blood plasma, is normally tightly regulated between 7.32 and 7.42, by the chemical buffers, the respiratory system, and the renal system. Aqueous buffer solutions will react with strong acids or strong bases by absorbing excess hydrogen ions, or hydroxide ions, replacing the strong acids and bases with weak acids and weak bases. This has the effect of damping the effect of pH changes, or reducing the pH change that would otherwise have occurred. But buffers cannot correct abnormal pH levels in a solution, be that solution in a test tube or in the extracellular fluid.
fluoride ions, the free scale is significantly different from both the total and seawater scales. Because of the relative unimportance of the fluoride ion, the total and seawater scales differ only very slightly. The pH of different cellular compartments, body fluids, and organs is usually tightly regulated in a process called acid-base homeostasis. The most common disorder in acid-base homeostasis is acidosis, which means an acid overload in the body, generally defined by pH falling below 7.35. Alkalosis is the opposite condition, with blood pH being excessively high. The pH of blood is usually slightly basic with a value of
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3,110,996
what is the term called for the sensation of needing to urinate immediately
Urinary urgency Urinary urgency is a sudden, compelling urge to urinate. MedNet defines it as “an immediate unstoppable urge to urinate, due to a sudden involuntary contraction of the muscular wall of the bladder.” It is often, though not necessarily, associated with urinary incontinence, polyuria, nocturia, and interstitial cystitis. It tends to increase with age. When uncontrollable, it is described as urge incontinence. Urinary urgency often occurs as a result of irritation and/or inflammation of the bladder wall (urothelium). In interstitial cystitis, urinary frequency and urgency are the hallmark symptoms, in addition to nocturia and dyspareunia. In many cases, these
Urination Urination is the release of urine from the urinary bladder through the urethra to the outside of the body. It is the urinary system's form of excretion. It is also known medically as micturition, voiding, uresis, or, rarely, emiction, and known colloquially by various names including peeing, weeing, and pissing. In healthy humans (and many other animals) the process of urination is under voluntary control. In infants, some elderly individuals, and those with neurological injury, urination may occur as a reflex. It is normal for adult humans to urinate up to seven times during the day. In some animals,
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3,110,997
how long does invanz stay in your system
an oral suspension, and as a solution for intravenous administration. When administered over one hour as an intravenous infusion, ciprofloxacin rapidly distributes into the tissues, with levels in some tissues exceeding those in the serum. Penetration into the central nervous system is relatively modest, with cerebrospinal fluid levels normally less than 10% of peak serum concentrations. The serum half-life of ciprofloxacin is about 4–6 hours, with 50-70% of an administered dose being excreted in the urine as unmetabolized drug. An additional 10% is excreted in urine as metabolites. Urinary excretion is virtually complete 24 hours after administration. Dose adjustment is
low affinity to voltage-dependent calcium channels. It has been theorised that it may act not by inhibiting calcium entry into cells, but rather by an intracellular mechanism such as antagonising calmodulin, a calcium binding protein. Flunarizine is well absorbed (>80%) from the gut and reaches maximal blood plasma concentrations after two to four hours, with more than 99% of the substance bound to plasma proteins. It readily passes the blood–brain barrier. When given daily, a steady state is reached after five to eight weeks. Concentrations in the brain are about ten times higher than in the plasma. The substance is
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3,110,998
an idiopathic condition associated with asprin treatment during certain viral infections
Reye syndrome Reye syndrome is a rapidly progressive encephalopathy. Symptoms may include vomiting, personality changes, confusion, seizures, and loss of consciousness. Even though liver toxicity typically occurs, jaundice usually does not. Death occurs in 20–40% of those affected and about a third of those who survive are left with a significant degree of brain damage. The cause of Reye syndrome is unknown. It usually begins shortly after recovery from a viral infection, such as influenza or chickenpox. About 90% of cases in children are associated with aspirin (salicylate) use. Inborn errors of metabolism are also a risk factor. Changes on
of acute appendicitis. In a person with an equivocal score of 5 or 6, a CT scan or ultrasound exam may be used to reduce the rate of negative appendectomy. The definitive diagnosis is based on pathology. The histologic finding of appendicitis is neutrophilic infiltrate of the muscularis propria. Periappendicitis, inflammation of tissues around the appendix, is often found in conjunction with other abdominal pathology. Children: Gastroenteritis, mesenteric adenitis, Meckel's diverticulitis, intussusception, Henoch–Schönlein purpura, lobar pneumonia, urinary tract infection (abdominal pain in the absence of other symptoms can occur in children with UTI), new-onset Crohn's disease or ulcerative colitis, pancreatitis,
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3,110,999
who discovered treacher collins syndrome and when was it first diagnosed
and potentially confirmation by genetic testing. Treacher Collins syndrome is not curable. Symptoms may be managed with reconstructive surgery, hearing aids, speech therapy, and other assistive devices. Life expectancy is generally normal. TCS occurs in about one in 50,000 people. The syndrome is named after Edward Treacher Collins, an English surgeon and ophthalmologist, who described its essential traits in 1900. Symptoms in people with Treacher Collins syndrome vary. Some individuals are so mildly affected that they remain undiagnosed, while others have moderate to severe facial involvement and life-threatening airway compromise. Most of the features of TCS are symmetrical and are
treatment with intravenous injections to treat the crisis. Individuals with Addison's disease have more than a doubled mortality rate. Furthermore, individuals with Addison's disease and diabetes mellitus have an almost 4 time increase in mortality compared to individuals with only diabetes. Addison’s disease is named after Thomas Addison, the British physician who first described the condition in "On the Constitutional and Local Effects of Disease of the Suprarenal Capsules" (1855). All of Addison's six original patients had tuberculosis of the adrenal glands. While Addison's six patients in 1855 all had adrenal tuberculosis, the term "Addison's disease" does not imply an
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3,111,000
what is the definition of an asthma attack
not the alveoli. An acute asthma exacerbation is commonly referred to as an "asthma attack". The classic symptoms are shortness of breath, wheezing, and chest tightness. The wheezing is most often when breathing out. While these are the primary symptoms of asthma, some people present primarily with coughing, and in severe cases, air motion may be significantly impaired such that no wheezing is heard. In children, chest pain is often present. Signs occurring during an asthma attack include the use of accessory muscles of respiration (sternocleidomastoid and scalene muscles of the neck), there may be a paradoxical pulse (a pulse
Asthma Asthma is a common long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and bronchospasm. Symptoms include episodes of wheezing, coughing, chest tightness, and shortness of breath. These episodes may occur a few times a day or a few times per week. Depending on the person, they may become worse at night or with exercise. Asthma is thought to be caused by a combination of genetic and environmental factors. Environmental factors include exposure to air pollution and allergens. Other potential triggers include medications such as aspirin and beta
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removal of excretory products from the human body
Excretion Excretion is a process by which metabolic waste is eliminated from an organism. In vertebrates this is primarily carried out by the lungs, kidneys and skin. This is in contrast with secretion, where the substance may have specific tasks after leaving the cell. Excretion is an essential process in all forms of life. For example, in mammals urine is expelled through the urethra, which is part of the excretory system. In unicellular organisms, waste products are discharged directly through the surface of the cell. During life activities such as cellular respiration, several chemical reactions take place in the body.
Detoxification Detoxification or detoxication (detox for short) is the physiological or medicinal removal of toxic substances from a living organism, including the human body, which is mainly carried out by the liver. Additionally, it can refer to the period of withdrawal during which an organism returns to homeostasis after long-term use of an addictive substance. In medicine, detoxification can be achieved by decontamination of poison ingestion and the use of antidotes as well as techniques such as dialysis and (in a limited number of cases) chelation therapy. Many alternative medicine practitioners promote various types of detoxification such as detoxification diets.
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ascites is one of the late features of
Ascites Ascites is the abnormal buildup of fluid in the abdomen. Technically, it is more than 25 mL of fluid in the peritoneal cavity. Symptoms may include increased abdominal size, increased weight, abdominal discomfort, and shortness of breath. Complications can include spontaneous bacterial peritonitis. In the developed world, the most common cause is liver cirrhosis. Other causes include cancer, heart failure, tuberculosis, pancreatitis, and blockage of the hepatic vein. In cirrhosis, the underlying mechanism involves high blood pressure in the portal system and dysfunction of blood vessels. Diagnosis is typically based on a examination together with ultrasound or a CT
scan. Testing the fluid can help in determining the underlying cause. Treatment often involves a low salt diet, medication such as diuretics, and draining the fluid. A transjugular intrahepatic portosystemic shunt (TIPS) may be placed but is associated with complications. Effects to treat the underlying cause, such as by a liver transplant may be considered. Of those with cirrhosis, more than half develop ascites in the ten years following diagnosis. Of those in this group who develop ascites, half will die within three years. The term is from the Greek "askítes" meaning "baglike". Mild ascites is hard to notice, but
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when do you need to do decompression stops
Decompression (diving) The decompression of a diver is the reduction in ambient pressure experienced during ascent from depth. It is also the process of elimination of dissolved inert gases from the diver's body, which occurs during the ascent, during pauses in the ascent known as decompression stops, and after surfacing until the gas concentrations reach equilibrium. Divers breathing gas at ambient pressure need to ascend at a rate determined by their exposure to pressure and the breathing gas in use. A diver who only breathes gas at atmospheric pressure when free-diving or snorkelling will not usually need to decompress, Divers
Physiology of decompression The physiology of decompression involves a complex interaction of gas solubility, partial pressures and concentration gradients, diffusion, bulk transport and bubble mechanics in living tissues. Gas is breathed at ambient pressure, and some of this gas dissolves into the blood and other fluids. Inert gas continues to be taken up until the gas dissolved in the tissues is in a state of equilibrium with the gas in the lungs, (see: "Saturation diving"), or the ambient pressure is reduced until the inert gases dissolved in the tissues are at a higher concentration than the equilibrium state, and start
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who sanctioned oral rehydration salts ( ors ) recipe
vomiting is not a contraindication to receiving oral rehydration therapy. In persons who are vomiting, drinking oral rehydration solution at a slow and continuous pace will help the vomiting to resolve. WHO and UNICEF jointly have developed official guidelines for the manufacture of oral rehydration solution and the oral rehydration salts used to make it (both often abbreviated as ORS). They also describe acceptable alternative preparations, depending on material availability. Commercial preparations are available as either pre-prepared fluids or packets of oral rehydration salts ready for mixing with water. The formula for the current WHO oral rehydration solution (also known
Alka-Seltzer Alka-Seltzer is an effervescent antacid and pain reliever first marketed by the Dr. Miles Medicine Company of Elkhart, Indiana, United States. Alka-Seltzer contains three active ingredients: aspirin (acetylsalicylic acid) (ASA), sodium bicarbonate, and anhydrous citric acid. The aspirin is a pain reliever and anti-inflammatory, the sodium bicarbonate is an antacid, and the citric acid reacts with the sodium bicarbonate and water to form effervescence. It was developed by head chemist Maurice Treneer. Alka-Seltzer is marketed for relief of minor aches, pains, inflammation, fever, headache, heartburn, stomachache, indigestion, acid reflux and hangovers, while neutralizing excess stomach acid. It was launched
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effect of increased carbon dioxide in the blood
Hypercapnia Hypercapnia, also known as hypercarbia and CO retention, is a condition of abnormally elevated carbon dioxide (CO) levels in the blood. Carbon dioxide is a gaseous product of the body's metabolism and is normally expelled through the lungs. Hypercapnia normally triggers a reflex which increases breathing and access to oxygen (O), such as arousal and turning the head during sleep. A failure of this reflex can be fatal, for example as a contributory factor in sudden infant death syndrome. Hypercapnia is the opposite of hypocapnia, the state of having abnormally reduced levels of carbon dioxide in the blood. Hypercapnia
suffix. It is a misspelling by writers who misunderstand that the word "hypercapnia" does not end in the same suffix that "apnea" does. Hypercapnia Hypercapnia, also known as hypercarbia and CO retention, is a condition of abnormally elevated carbon dioxide (CO) levels in the blood. Carbon dioxide is a gaseous product of the body's metabolism and is normally expelled through the lungs. Hypercapnia normally triggers a reflex which increases breathing and access to oxygen (O), such as arousal and turning the head during sleep. A failure of this reflex can be fatal, for example as a contributory factor in sudden
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medical term for flow or discharge from the nose
Rhinorrhea Rhinorrhea or rhinorrhoea is a condition where the nasal cavity is filled with a significant amount of mucus fluid. The condition, commonly known as a runny nose, occurs relatively frequently. Rhinorrhea is a common symptom of allergies (hay fever) or certain diseases, such as the common cold. It can be a side effect of crying, exposure to cold temperatures, cocaine abuse or withdrawal, such as from opioids like methadone. Treatment for rhinorrhea is not usually necessary, but there are a number of medical treatments and preventive techniques available. The term was coined in 1866 and is a combination of
Nosebleed A nosebleed, also known as epistaxis ( ), is the common occurrence of bleeding from the nose. It is usually noticed when blood drains out through the nostrils. There are two types: anterior (the most common), and posterior (less common, more likely to require medical attention). Sometimes in more severe cases, the blood can come up the nasolacrimal duct and out from the eye. Fresh blood and clotted blood can also flow down into the stomach and cause nausea and vomiting. Although the sight of large amounts of blood can be alarming and may warrant medical attention, nosebleeds are
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alteration of consciousness during deep sea diving is known as
Nitrogen narcosis Narcosis while diving (also known as nitrogen narcosis, inert gas narcosis, raptures of the deep, Martini effect) is a reversible alteration in consciousness that occurs while diving at depth. It is caused by the anesthetic effect of certain gases at high pressure. The Greek word "ναρκωσις" (narcosis) is derived from "narke", "temporary decline or loss of senses and movement, numbness", a term used by Homer and Hippocrates. Narcosis produces a state similar to drunkenness (alcohol intoxication), or nitrous oxide inhalation. It can occur during shallow dives, but does not usually become noticeable at depths less than . Except
Decompression sickness Decompression sickness (DCS; also known as divers' disease, the bends, aerobullosis, or caisson disease) describes a condition arising from dissolved gases coming out of solution into bubbles inside the body on depressurisation. DCS most commonly refers to problems arising from underwater diving decompression (i.e., during ascent), but may be experienced in other depressurisation events such as emerging from a caisson, flying in an unpressurised aircraft at altitude, and extravehicular activity from spacecraft. DCS and arterial gas embolism are collectively referred to as decompression illness. Since bubbles can form in or migrate to any part of the body, DCS
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which route of administration is most likely to subject a drug to a first pass effect
THC, is enhanced by transformation of a significant portion into 11-hydroxy-THC that more readily crosses the blood brain barrier and thus achieves greater potency than the original THC. [Cannabis edible] First pass metabolism may occur in the liver (for propranolol, lidocaine, chloromethiasole and GTN) or in the gut (for benzylpenicillin and insulin). After a drug is swallowed, it is absorbed by the digestive system and enters the hepatic portal system. It is carried through the portal vein into the liver before it reaches the rest of the body. The liver metabolizes many drugs, sometimes to such an extent that only
be absorbed directly into the systemic circulation. Drugs with high first pass effect have a considerably higher oral dose than sublingual or parenteral dose. There is marked individual variation in the oral dose due to differences in the extent of first pass metabolism. Oral bioavailability is apparently increased in patients with severe liver diseases like cirrhosis. It is also increased if another drug competing with it in first pass metabolism is given concurrently. E.g. propranolol and chlorpromazine. First pass effect The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the
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inflammatory lung condition caused by bacteria medical term
Respiratory disease Respiratory disease is a medical term that encompasses pathological conditions affecting the organs and tissues that make gas exchange possible in higher organisms, and includes conditions of the upper respiratory tract, trachea, bronchi, bronchioles, alveoli, pleura and pleural cavity, and the nerves and muscles of breathing. Respiratory diseases range from mild and self-limiting, such as the common cold, to life-threatening entities like bacterial pneumonia, pulmonary embolism, acute asthma and lung cancer. The study of respiratory disease is known as pulmonology. A doctor who specializes in respiratory disease is known as a pulmonologist, a chest medicine specialist, a respiratory
which can either be acute or chronic. Acute bronchitis is usually caused by viral or bacterial infections. Most sufferers of chronic bronchitis also suffer from chronic obstructive pulmonary disease (COPD), and this is usually associated with smoking or long-term exposure to irritants. The left main bronchus departs from the trachea at a greater angle than that of the right main bronchus. The right bronchus is also wider than the left and these differences predispose the right lung to aspirational problems. If food, liquids, or foreign bodies are aspirated, they will tend to lodge in the right main bronchus. Bacterial pneumonia
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where does most reabsorption in the renal tubule occur
Sodium passes along an electrochemical gradient (passive transport) from the lumen into the tubular cell, together with water and chloride which also diffuse passively. Water is reabsorbed to the same degree, resulting in the concentration in the end of the proximal tubule being the same as in the beginning. In other words, the reabsorption in the proximal tubule is isosmotic. Sodium is reabsorbed in the thick ascending limb of loop of Henle, by Na-K-2Cl symporter and Na-H antiporter. It goes against its chemical driving force, but the high electrical driving force renders the overall electrochemical driving force positive anyway, availing
to the filtrate in the nephron and aids in the reabsorption of water. Blood is filtered in the glomerulus by solute size. Ions such as sodium, chloride, potassium, and calcium are easily filtered, as is glucose. Proteins are not passed through the glomerular filter because of their large size, and do not appear in the filtrate or urine unless a disease process has affected the glomerular capsule or the proximal and distal convoluted tubules of the nephron. Though the renal medulla only receives a small percentage of the renal blood flow, the oxygen extraction is very high, causing a low
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excessive amount of sugar in the blood is called
Hyperglycemia Hyperglycemia (also spelled hyperglycaemia or hyperglycæmia), also known as high blood sugar, is a condition in which an excessive amount of glucose circulates in the blood plasma. This is generally a blood sugar level higher than 11.1 mmol/l (200 mg/dl), but symptoms may not start to become noticeable until even higher values such as 15–20 mmol/l (~250–300 mg/dl). A subject with a consistent range between ~5.6 and ~7 mmol/l (100–126 mg/dl) (American Diabetes Association guidelines) is considered slightly hyperglycemic, while above 7 mmol/l (126 mg/dl) is generally held to have diabetes. For diabetics, glucose levels that are considered to
Hypoglycemia Hypoglycemia, also known as low blood sugar, is when blood sugar decreases to below normal levels. This may result in a variety of symptoms including clumsiness, trouble talking, confusion, loss of consciousness, seizures or death. A feeling of hunger, sweating, shakiness and weakness may also be present. Symptoms typically come on quickly. The most common cause of hypoglycemia is medications used to treat diabetes mellitus such as insulin and sulfonylureas. Risk is greater in diabetics who have eaten less than usual, exercised more than usual or have drunk alcohol. Other causes of hypoglycemia include kidney failure, certain tumors, such
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where can the gene linked to cystic fibrosis be found
Cystic fibrosis Cystic fibrosis (CF) is a genetic disorder that affects mostly the lungs, but also the pancreas, liver, kidneys, and intestine. Long-term issues include difficulty breathing and coughing up mucus as a result of frequent lung infections. Other signs and symptoms may include sinus infections, poor growth, fatty stool, clubbing of the fingers and toes, and infertility in most males. Different people may have different degrees of symptoms. CF is inherited in an autosomal recessive manner. It is caused by the presence of mutations in both copies of the gene for the cystic fibrosis transmembrane conductance regulator (CFTR) protein.
produce proteins that do not use energy (in the form of ATP) normally, do not allow chloride, iodide, and thiocyanate to cross the membrane appropriately, and degrade at a faster rate than normal. Mutations may also lead to fewer copies of the CFTR protein being produced. The protein created by this gene is anchored to the outer membrane of cells in the sweat glands, lungs, pancreas, and all other remaining exocrine glands in the body. The protein spans this membrane and acts as a channel connecting the inner part of the cell (cytoplasm) to the surrounding fluid. This channel is
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what does sodium pentothal do to the body
three drugs administered during most lethal injections in the United States, but the U.S. manufacturer Hospira stopped manufacturing the drug and the EU banned the export of the drug for this purpose. Although thiopental abuse carries a dependency risk, its recreational use is rare. Sodium thiopental is an ultra-short-acting barbiturate and has been used commonly in the induction phase of general anesthesia. Its use has been largely replaced with that of propofol, but retains popularity as an induction agent for rapid sequence intubation and in obstetrics. Following intravenous injection, the drug rapidly reaches the brain and causes unconsciousness within 30–45
hounds will have prolonged recoveries from sodium thiopental due to their lack of body fat and their lean body mass. Conversely, obese animals will have rapid recoveries, but it will be some time before it is entirely removed (metabolized) from their bodies. Sodium thiopental is always administered intravenously, as it can be fairly irritating; severe tissue necrosis and sloughing can occur if it is injected incorrectly into the tissue around a vein. Sodium thiopental decreases the cardiac stroke volume, which results in a decrease in cardiac output. The decrease in cardiac output occurs in conjunction with a decrease in systemic
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what is the first step in the major events of the inflammatory process
Sydenham and Virchow. Redness and heat are due to increased blood flow at body core temperature to the inflamed site; swelling is caused by accumulation of fluid; pain is due to the release of chemicals such as bradykinin and histamine that stimulate nerve endings. Loss of function has multiple causes. Acute inflammation of the lung (usually caused in response to pneumonia) does not cause pain unless the inflammation involves the parietal pleura, which does have pain-sensitive nerve endings. The process of acute inflammation is initiated by resident immune cells already present in the involved tissue, mainly resident macrophages, dendritic cells,
to cease once the stimulus has been removed. As defined, acute inflammation is an immunovascular response to an inflammatory stimulus. This means acute inflammation can be broadly divided into a vascular phase that occurs first, followed by a cellular phase involving immune cells (more specifically myeloid granulocytes in the acute setting). The vascular component of acute inflammation involves the movement of plasma fluid, containing important proteins such as fibrin and immunoglobulins (antibodies), into inflamed tissue. Upon contact with PAMPs, tissue macrophages and mastocytes release vasoactive amines such as histamine and serotonin, as well as eicosanoids such as prostaglandin E2 and
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what type of athlete would benefit from altitude training
Altitude training Altitude training is the practice by some endurance athletes of training for several weeks at high altitude, preferably over above sea level, though more commonly at intermediate altitudes due to the shortage of suitable high-altitude locations. At intermediate altitudes, the air still contains approximately 20.9% oxygen, but the barometric pressure and thus the partial pressure of oxygen is reduced. Depending very much on the protocols used, the body may acclimate to the relative lack of oxygen in one or more ways such as increasing the mass of red blood cells and hemoglobin, or altering muscle metabolism. Proponents claim
a hormone secreted by the kidneys, EPO stimulates red blood cell production from bone marrow in order to increase hemoglobin saturation and oxygen delivery. Some athletes demonstrate a strong red blood cell response to altitude while others see little or no gain in red cell mass with chronic exposure. It is uncertain how long this adaptation takes because various studies have found different conclusions based on the amount of time spent at high altitudes. While EPO occurs naturally in the body, it is also made synthetically to help treat patients suffering from kidney failure and to treat patients during chemotherapy.
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when does a man exert more pressure on floor while standing or while walking
object's weight divided by contact area. The ground pressure of motorized vehicles is often compared to the ground pressure of a human foot, which can be 60 - 80 kPa while walking or as much as 13 MPa for a person in spike heels. Increasing the size of the contact area on the ground (the "footprint") in relation to the weight decreases the ground pressure. Ground pressure of 14 kPa (2 psi) or less is recommended for fragile ecosystems like marshes. Decreasing the ground pressure increases the flotation, allowing easier passage of the body over soft terrain. This is often
Orthostatic hypotension Orthostatic hypotension, also known as postural hypotension, occurs when a person's blood pressure falls when suddenly standing up from a lying or sitting position. It is defined as a fall in systolic blood pressure of at least 20 mm Hg or diastolic blood pressure of at least 10 mm Hg when a person assumes a standing position. It occurs predominantly by delayed constriction of the lower body blood vessels, which is normally required to maintain an adequate blood pressure when changing position to standing. As a result, blood pools in the blood vessels of the legs for a
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how much voltage does an electric eel have
an electric potential difference. In the electric eel, some 5,000 to 6,000 stacked electroplaques can make a shock up to 860 volts and 1 ampere of current (860 watts) for two milliseconds (ms). Such a shock is extremely unlikely to be deadly for an adult human, due to the very short duration of the discharge. Atrial fibrillation requires that roughly 700 mA be delivered across the heart muscle for 30 ms or more, far longer than the eel can produce. Still, this level of current is reportedly enough to produce a brief and painful numbing shock likened to a stun
the ability to generate two types of electric organ discharges: low voltage and high voltage. These organs are made of electrocytes, lined up so a current of ions can flow through them and stacked so each one adds to a potential difference. When the eel finds its prey, the brain sends a signal through the nervous system to the electrocytes. This opens the ion channels, allowing sodium to flow through, reversing the polarity momentarily. By causing a sudden difference in electric potential, it generates an electric current in a manner similar to a battery, in which stacked plates each produce
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where does the filtrate go after it leaves the bowman 's capsule
platelets and large proteins do not. As a result, the filtrate leaving the Bowman's capsule is very similar to blood plasma (filtrate or glomerular filtrate is composed of blood plasma minus plasma protein i.e. it contains all the components of blood plasma except the proteins) in composition as it passes into the proximal convoluted tubule. Measuring the glomerular filtration rate (GFR) is a diagnostic test of kidney function. A decreased GFR may be a sign of renal failure. A number of diseases can result in various problems within the glomerulus. Examples include acute proliferative (endocapillary) glomerulonephritis, mesangioproliferative glomerulonephritis, mesangiocapillary (membranoproliferative)
"poles": Inside the capsule, the layers are as follows, from outside to inside: The process of filtration of the blood in the Bowman's capsule is ultrafiltration (or glomerular filtration), and the normal rate of filtration is 125 ml/min, equivalent to 80 times the daily blood volume. Any proteins under roughly 30 kilodaltons can pass freely through the membrane, although there is some extra hindrance for negatively charged molecules due to the negative charge of the basement membrane and the podocytes. Any small molecules such as water, glucose, salt (NaCl), amino acids, and urea pass freely into Bowman's space, but cells,
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xerophthalmia in human beings is caused due to deficiency of vitamin
Xerophthalmia Xerophthalmia (from Ancient Greek xērós (ξηρός) meaning dry and ophthalmos (οφθαλμός) meaning eye) is a medical condition in which the eye fails to produce tears. It may be caused by vitamin A deficiency, which is sometimes used to describe that condition, although there may be other causes. Xerophthalmia caused by a severe vitamin A deficiency is described by pathologic dryness of the conjunctiva and cornea. The conjunctiva becomes dry, thick and wrinkled. If untreated, it can lead to corneal ulceration and ultimately to blindness as a result of corneal damage. Xerophthalmia usually implies a destructive dryness of the conjunctival
term can describe oral and eye dryness that is not caused by autoimmune diseases (e.g., Sjögren syndrome). Oral dryness may also be caused by mouth breathing, usually caused by partial obstruction of the upper respiratory tract. Examples include hemorrhage, vomiting, diarrhea, and fever. Alcohol may be involved in the cause of salivary gland disease, liver disease, or dehydration. Smoking is another possible cause. Other recreational drugs such as methamphetamine, cannabis, hallucinogens, or heroin, may be implicated. Hormonal disorders, such as poorly controlled diabetes, chronic graft versus host disease or low fluid intake in people undergoing haemodialysis for renal impairment may
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what would a score of 15 on the glascow coma scale indicate
the Eye Response element. Note that a motor response in any limb is acceptable. The scale is composed of three tests: eye, verbal and motor responses. The three values separately as well as their sum are considered. The lowest possible GCS (the sum) is 3 (deep coma or death), while the highest is 15 (fully awake person). There are four grades starting with the most severe: There are five grades starting with the most severe: There are six grades: Individual elements as well as the sum of the score are important. Hence, the score is expressed in the form "GCS
9 = E2 V4 M3 at 07:35". Generally, brain injury is classified as: Tracheal intubation and severe facial/eye swelling or damage make it impossible to test the verbal and eye responses. In these circumstances, the score is given as 1 with a modifier attached (e.g. "E1c", where "c" = closed, or "V1t" where t = tube). Often the 1 is left out, so the scale reads Ec or Vt. A composite might be "GCS 5tc". This would mean, for example, eyes closed because of swelling = 1, intubated = 1, leaving a motor score of 3 for "abnormal flexion". The
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when does a dead dog start to decompose
the Greek word "taphos", meaning tomb. One can differentiate abiotic from biotic decomposition (biodegradation). The former means "degradation of a substance by chemical or physical processes, e.g., hydrolysis. The latter means "the metabolic breakdown of materials into simpler components by living organisms", typically by microorganisms. Decomposition begins at the moment of death, caused by two factors: 1.) autolysis, the breaking down of tissues by the body's own internal chemicals and enzymes, and 2.) putrefaction, the breakdown of tissues by bacteria. These processes release compounds such as cadaverine and putrescine, that are the chief source of the unmistakably putrid odor of
time. Among those animals that have a heart, the "fresh" stage begins immediately after the heart stops beating. From the moment of death, the body begins cooling or warming to match the temperature of the ambient environment, during a stage called rigor mortis. Shortly after death, within three to six hours, the muscular tissues become rigid and incapable of relaxing, during a stage called rigor mortis. Since blood is no longer being pumped through the body, gravity causes it to drain to the dependent portions of the body, creating an overall bluish-purple discolouration termed livor mortis or, more commonly, lividity.
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what is the common end result in all shock states
about 2% of the cell's total need per hour, even restoring oxygen is futile at this point because there is no adenosine to phosphorylate into ATP. The first change seen in shock is an increased cardiac output followed by a decrease in mixed venous oxygen saturation (SmvO2) as measured in the pulmonary artery via a pulmonary artery catheter. Central venous oxygen saturation (ScvO2) as measured via a central line correlates well with SmvO2 and are easier to acquire. If shock progresses anaerobic metabolism will begin to occur with an increased blood lactic acid as the result. While many laboratory tests
Shock (circulatory) Shock is the state of not enough blood flow to the tissues of the body as a result of problems with the circulatory system. Initial symptoms may include weakness, fast heart rate, fast breathing, sweating, anxiety, and increased thirst. This may be followed by confusion, unconsciousness, or cardiac arrest as complications worsen. Shock is divided into four main types based on the underlying cause: low volume, cardiogenic, obstructive, and distributive shock. Low volume shock may be from bleeding, vomiting, or pancreatitis. Cardiogenic shock may be due to a heart attack or cardiac contusion. Obstructive shock may be due
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what is the relatively rare condition that can cause respiratory ​ depression
Hypoventilation Hypoventilation (also known as respiratory depression) occurs when ventilation is inadequate ("hypo" meaning "below") to perform needed gas exchange. By definition it causes an increased concentration of carbon dioxide (hypercapnia) and respiratory acidosis. Hypoventilation is not synonymous with respiratory arrest, in which breathing ceases entirely and death occurs within minutes due to hypoxia and leads rapidly into complete anoxia, although both are medical emergencies. Hypoventilation can be considered a precursor to hypoxia and its lethality is attributed to hypoxia with carbon dioxide toxicity. Hypoventilation may be caused by: As a side effect of medicines or recreational drugs, hypoventilation may
become potentially life-threatening. Many different central nervous system (CNS) depressant drugs such as ethanol, benzodiazepines, barbiturates, GHB, sedatives and opioids produce respiratory depression when taken in large or excessive doses, or mixed with other depressants. Strong opiates (such as fentanyl, heroin, or morphine), barbiturates, and certain benzodiazepines (short acting ones and alprazolam) are known for depressing respiration. In an overdose, an individual may cease breathing entirely (go into respiratory arrest) which is rapidly fatal without treatment. Opioids, in overdose or combined with other depressants, are notorious for such fatalities. Respiratory stimulants such as nikethamide were traditionally used to counteract respiratory
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obligate anaerobic bacteria may be killed by high doses of
Obligate anaerobe Obligate anaerobes are microorganisms killed by normal atmospheric concentrations of oxygen (20.95% O). Oxygen tolerance varies between species, some capable of surviving in up to 8% oxygen, others losing viability unless the oxygen concentration is less than 0.5%. An important distinction needs to be made here between the obligate anaerobes and the microaerophiles. Microaerophiles, like the obligate anaerobes, are damaged by normal atmospheric concentrations of oxygen. However, microaerophiles metabolise energy aerobically, and obligate anaerobes metabolise energy anaerobically. Microaerophiles therefore require oxygen (typically 2–10% O) for growth. Obligate anaerobes do not. The oxygen sensitivity of obligate anaerobes has been
their hosts cellular defences, including the ability to survive in distinct cellular compartments. One of the mechanisms that hosts employ in their attempt to reduce the replication and spread of pathogens is apoptosis (programmed cell death). Some obligate parasites have developed ways to suppress this phenomenon, for example "Toxoplasma gondii" although the mechanism is not yet fully understood. Changes in a host’s behaviour following infection with obligate parasites are extremely common. Unusual behaviour observed in infected individuals is noted, and if its complexity suggests that this behaviour will benefit the transmission of the parasite, then this is said to be
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what are the effects of extreme sleep deprivation
past stage 1 of NREM sleep. In addition to insomnia, patients may experience panic attacks, paranoia, phobias, hallucinations, rapid weight loss, and dementia. Death usually occurs between 7 and 36 months from onset. Sleep deprivation Sleep deprivation commonly known as insufficient sleep is the condition of not having enough sleep. It can be either chronic or acute. The levels of sleep deprivation can vary widely. A chronic sleep-restricted state can cause fatigue, daytime sleepiness, clumsiness and weight loss or weight gain. It adversely affects the brain and cognitive function. However, in a subset of cases sleep deprivation can, paradoxically, lead
Sleep deprivation Sleep deprivation commonly known as insufficient sleep is the condition of not having enough sleep. It can be either chronic or acute. The levels of sleep deprivation can vary widely. A chronic sleep-restricted state can cause fatigue, daytime sleepiness, clumsiness and weight loss or weight gain. It adversely affects the brain and cognitive function. However, in a subset of cases sleep deprivation can, paradoxically, lead to increased energy and alertness and enhanced mood; although its long-term consequences have never been evaluated, it has even been used as a treatment for depression. Few studies have compared the effects of
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the decreased amount of oxygen in the bloodstream resulting from respiratory insufficiency is called
altitudes and was defined generally as defective oxygenation of the blood. Hypoxemia Hypoxemia (or hypoxaemia in British English) is an abnormally low level of oxygen in the blood. More specifically, it is oxygen deficiency in arterial blood. Hypoxemia has many causes, often respiratory disorders, and can cause tissue hypoxia as the blood is not supplying enough oxygen to the body. "Hypoxemia" refers to low oxygen in the blood, and the more general term "hypoxia" is an abnormally low oxygen content in any tissue or organ, or the body as a whole. Hypoxemia can cause hypoxia (hypoxemic hypoxia), but hypoxia can
Ischemia Ischemia or ischaemia is a restriction in blood supply to tissues, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive). Ischemia is generally caused by problems with blood vessels, with resultant damage to or dysfunction of tissue. It also means local anemia in a given part of a body sometimes resulting from congestion (such as vasoconstriction, thrombosis or embolism). Ischemia comprises not only insufficiency of oxygen, but also reduced availability of nutrients and inadequate removal of metabolic wastes. Ischemia can be partial (poor perfusion) or total. Since oxygen is carried to tissues in
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what does mi stand for in medical terms
accompanied by either typical symptoms, pathological Q waves, ST elevation or depression or coronary intervention are diagnostic of MI. Previous WHO criteria formulated in 1979 put less emphasis on cardiac biomarkers; according to these, a patient is diagnosed with myocardial infarction if two (probable) or three (definite) of the following criteria are satisfied: The general appearance of patients may vary according to the experienced symptoms; the patient may be comfortable, or restless and in severe distress with an increased respiratory rate. A cool and pale skin is common and points to vasoconstriction. Some patients have low-grade fever (38–39 °C). Blood
diagnosis when a person's history, physical exam, ECG and cardiac biomarkers suggest the likelihood of a problem. Cardiac markers or cardiac enzymes are proteins that leak out of injured myocardial cells through their damaged cell membranes into the bloodstream. Until the 1980s, the enzymes SGOT and LDH were used to assess cardiac injury. Now, the markers most widely used in detection of MI are "MB" subtype of the enzyme creatine kinase and cardiac troponins T and I as they are more specific for myocardial injury. The cardiac troponins T and I which are released within 4–6 hours of an attack
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a deficiency of thiamin causes a disorder called
Thiamine deficiency Thiamine deficiency is a medical condition of low levels of thiamine (vitamin B1). A severe and chronic form is known as beriberi. There are two main types in adults: wet beriberi, and dry beriberi. Wet beriberi affects the cardiovascular system resulting in a fast heart rate, shortness of breath, and leg swelling. Dry beriberi affects the nervous system resulting in numbness of the hands and feet, confusion, trouble moving the legs, and pain. A form with loss of appetite and constipation may also occur. Another type, acute beriberi, is found mostly in babies and presents with loss of
motion and sensation of the hands and feet indeed sometimes of the whole body." As most feedstuffs used in poultry diets contain enough quantities of vitamins to meet the requirements in this species, deficiencies in this vitamin do not occur with commercial diets. This was, at least, the opinion in the 1960s. Mature chickens show signs 3 weeks after being fed a deficient diet. In young chicks, it can appear before 2 weeks of age. Onset is sudden in young chicks. There is anorexia and an unsteady gait. Later on, there are locomotor signs, beginning with an apparent paralysis of
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what is m p v in blood test
Mean platelet volume Mean platelet volume (MPV) is a machine-calculated measurement of the average size of platelets found in blood and is typically included in blood tests as part of the CBC. Since the average platelet size is larger when the body is producing increased numbers of platelets, the MPV test results can be used to make inferences about platelet production in bone marrow or platelet destruction problems. MPV is higher when there is destruction of platelets. This may be seen in inflammatory bowel disease, immune thrombocytopenic purpura (ITP), myeloproliferative diseases and Bernard-Soulier syndrome. It may also be related to
Urine flow rate Urine flow rate or urinary flow rate is the volumetric flow rate of urine during urination. It is a measure of the quantity of urine excreted in a specified period of time (per second or per minute). It is measured with uroflowmetry, a type of flowmetry. The letters "V" (for volume) and "Q" (a conventional symbol for flow rate) are both used as a symbol for urine flow rate. The V often has a dot (overdot), that is, V̇ ("V-dot"). Q indicates the maximum flow rate. Q is used as an indicator for the diagnosis of enlarged
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where does reabsorption of sodium and chloride ions occur
Renal sodium reabsorption Renal reabsorption of sodium (Na) is a part of renal physiology. It uses Na-H antiport, Na-glucose symport, sodium ion channels (minor). It is stimulated by angiotensin II and aldosterone, and inhibited by atrial natriuretic peptide. It is very efficient, since more than 25,000 mmoles/day of sodium is filtered into the nephron, but only ~100 mmoles/day, or less than 0.4% remains in the final urine. Most of the reabsorption (65%) occurs in the proximal tubule. In the latter part it is favoured by an electrochemical driving force, but initially it needs the cotransporter SGLT and the Na-H antiporter.
some sodium to diffuse passively either the transcellular or paracellular way.. In the distal convoluted tubule sodium is transported against an electrochemical gradient by sodium-chloride symporters. The principal cells are the sodium-transporting cells in the collecting duct system. Although only a fragment of total reabsorption happens here, it is the main part of intervention. This is e.g. done by endogenous production of aldosterone, increasing reabsorption. Since the normal excretion rate of sodium is ~100mmoles/day, then a regulation of the absorption of still more than 1000 mmoles/day entering the collecting duct system has a substantial influence of the total sodium excreted.
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class of drugs administered to lower high blood pressure
Antihypertensive drug Antihypertensives are a class of drugs that are used to treat hypertension (high blood pressure). Antihypertensive therapy seeks to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Evidence suggests that reduction of the blood pressure by 5 mmHg can decrease the risk of stroke by 34%, of ischaemic heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease. There are many classes of antihypertensives, which lower blood pressure by different means. Among the most important and most widely used drugs are thiazide diuretics, calcium channel blockers,
of hypertension. However, they may be useful for some men with symptoms of prostate disease. Vasodilators act directly on the smooth muscle of arteries to relax their walls so blood can move more easily through them; they are only used in hypertensive emergencies or when other drugs have failed, and even so are rarely given alone. Sodium nitroprusside, a very potent, short-acting vasodilator, is most commonly used for the quick, temporary reduction of blood pressure in emergencies (such as malignant hypertension or aortic dissection). Hydralazine and its derivatives are also used in the treatment of severe hypertension, although they should
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where does most absorption occur in the nephron
passive: it is dependent on the intracapillary blood pressure. About one-fifth of the plasma is filtered as the blood passes through the glomerular capillaries; four-fifths continues into the peritubular capillaries. Normally the only components of the blood that are not filtered into Bowman's capsule are blood proteins, red blood cells, white blood cells and platelets. Over 150 liters of fluid enter the glomeruli of an adult every day: 99% of the water in that filtrate is reabsorbed. Reabsorption occurs in the renal tubules and is either passive, due to diffusion, or active, due to pumping against a concentration gradient. Secretion
to be filtered out of the blood plasma, and into the interior of Bowman's capsule, called Bowman's space. Only about a fifth of the plasma is filtered in the glomerulus. The rest passes into an efferent arteriole. The diameter of the efferent arteriole is smaller than that of the afferent, and this difference increases the hydrostatic pressure in the glomerulus. The Bowman's capsule, also called the glomerular capsule, surrounds the glomerulus. It is composed of a visceral inner layer formed by specialized cells called podocytes, and a parietal outer layer composed of simple squamous epithelium. Fluids from blood in the
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all of the air that can be forced out of your lungs following a normal expiration is called
Exhalation Exhalation (or expiration) is the flow of the breath out of an organism. In humans it is the movement of air from the lungs out of the airways, to the external environment during breathing. This happens due to elastic properties of the lungs, as well as the internal intercostal muscles which lower the rib cage and decrease thoracic volume. As the thoracic diaphragm relaxes during exhalation it causes the tissue it has depressed to rise superiorly and put pressure on the lungs to expel the air. During forced exhalation, as when blowing out a candle, expiratory muscles including the
a person's capacity to inhale and exhale in different circumstances. The volume of air inhaled and exhaled by a person at rest is the tidal volume (normally 500-750mL); the inspiratory reserve volume and expiratory reserve volume are the additional amounts a person is able to forcibly inhale and exhale respectively. The summed total of forced inspiration and expiration is a person's vital capacity. Not all air is expelled from the lungs even after a forced breath out; the remainder of the air is called the residual volume. Together these terms are referred to as lung volumes. Pulmonary plethysmographs are used
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the chest during breathing, especially when one inhales and exhales. It feels worse with deep breathing, coughing, sneezing, or laughing. The pain may stay in one place, or it may spread to the shoulder or back. Sometimes, it becomes a fairly constant dull ache. Depending on its cause, pleuritic chest pain may be accompanied by other symptoms: The pleural space can be invaded by fluid, air, and particles from other parts of the body, which fairly complicates diagnosis. Viral infection (coxsackie B virus, HRSV, CMV, adenovirus, EBV, parainfluenza, influenza) is the most common cause of pleurisy. However, many other different
Abdominal distension Abdominal distension occurs when substances, such as air (gas) or fluid, accumulate in the abdomen causing its expansion. It is typically a symptom of an underlying disease or dysfunction in the body, rather than an illness in its own right. People suffering from this condition often describe it as "feeling bloated". Sufferers often experience a sensation of fullness, abdominal pressure and possibly nausea, pain or cramping. In the most extreme cases, upward pressure on the diaphragm and lungs can also cause shortness of breath. Through a variety of causes (see below), bloating is most commonly due to buildup
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a noninvasive method to monitor oxygen saturation levels in arterial blood is
Pulse oximetry Pulse oximetry is a noninvasive method for monitoring a person's oxygen saturation (S). Though its reading of Sp (peripheral oxygen saturation) is not always identical to the more desirable reading of Sa (arterial oxygen saturation) from arterial blood gas analysis, the two are correlated well enough that the safe, convenient, noninvasive, inexpensive pulse oximetry method is valuable for measuring oxygen saturation in clinical use. In its most common (transmissive) application mode, a sensor device is placed on a thin part of the patient's body, usually a fingertip or earlobe, or in the case of an infant, across a
requirements, the pH-stat method may lead to cerebral microembolisation and intracranial hypertension. These are typical reference ranges, although various analysers and laboratories may employ different ranges. Contamination of the sample with room air will result in abnormally low carbon dioxide and possibly elevated oxygen levels, and a concurrent elevation in pH. Delaying analysis (without chilling the sample) may result in inaccurately low oxygen and high carbon dioxide levels as a result of ongoing cellular respiration. The normal range for pH is 7.35–7.45. As the pH decreases (< 7.35), it implies acidosis, while if the pH increases (> 7.45) it implies
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pneumonia directly affects which part of the body
Pneumonia Pneumonia is an inflammatory condition of the lung affecting primarily the small air sacs known as alveoli. Typically symptoms include some combination of productive or dry cough, chest pain, fever, and trouble breathing. Severity is variable. Pneumonia is usually caused by infection with viruses or bacteria and less commonly by other microorganisms, certain medications and conditions such as autoimmune diseases. Risk factors include other lung diseases such as cystic fibrosis, COPD, and asthma, diabetes, heart failure, a history of smoking, a poor ability to cough such as following a stroke, or a weak immune system. Diagnosis is often based
Pneumonia (non-human) Pneumonia is an illness which can result from a variety of causes, including infection with bacteria, viruses, fungi, or parasites. Pneumonia can occur in any animal with lungs, including mammals, birds, and reptiles. Symptoms associated with pneumonia include fever, fast or difficult breathing, nasal discharge, and decreased activity. Different animal species have distinct lung anatomy and physiology and are thus affected by pneumonia differently. Differences in anatomy, immune systems, diet, and behavior also affects the particular microorganisms commonly causing pneumonia. Diagnostic tools include physical examination, testing of the sputum, and x-ray investigation. Treatment depends on the cause of
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A.J. stands by, he relapses into depression. Tony eavesdrops on Joane, Carmela and Kelli discussing Chris' death. On a private trip to Las Vegas, he receives another call from Phil, who refuses to assist with the asbestos removal and mocks him over Chris' death. Tony meets Sonya, a stripper Chris knew, and tells her about his death. They have sex and smoke marijuana; she tells him he seems sad. They take peyote and win in roulette. Tony mumbles "he's dead" and collapses on the floor laughing, seemingly attributing his winning streak to the fact Chris is no longer in his
Heroin Heroin, also known as diamorphine among other names, is an opioid most commonly used as a recreational drug for its euphoric effects. Medically it is used in several countries to relieve pain or in opioid replacement therapy. Heroin is typically injected, usually into a vein; however, it can also be smoked, snorted or inhaled. The onset of effects is usually rapid and lasts for a few hours. Common side effects include respiratory depression (decreased breathing), dry mouth, drowsiness, impaired mental function, constipation, and addiction. Side effects of use by injection can include abscesses, infected heart valves, blood borne infections,
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when was the last time houston astros were in the world series
the U.S. crewed space program—was adopted three years later, when they moved into the Astrodome, the first domed sports stadium. The Astros played in the NL from 1962 to 2012, first in the West Division from 1969 to 1993, followed by the Central Division from 1994 to 2012. The team was reclassified to the American League West from 2013 onward. While a member of the NL, the Astros played in one World Series in 2005, losing in four games to the Chicago White Sox. In 2017, they became the first franchise in MLB history to have won a pennant in
March 31, 2013, where they were victorious over their in-state division competitor, the Texas Rangers, with a score of 8–2. On September 29, the Astros completed their first year in the American League, losing 5–1 in a 14-inning game to the New York Yankees. The Astros finished the season with a 51–111 record (a franchise worst) with a season ending 15-game losing streak, again surpassing their worst record from the previous season. The team finished 45 games behind the division winner Oakland Athletics, further adding to their futility. This marked three consecutive years that the Astros had lost more than
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when was the ballpark in arlington tx built
The Ballpark in Arlington, began on April 2, 1992 a short distance away from Arlington Stadium, the stadium it would replace, and the new Ballpark in Arlington opened on April 1, 1994 in an exhibition contest between the Rangers and the New York Mets. The first official game was on April 11 against the Milwaukee Brewers. The largest crowd to watch a Rangers baseball game was on October 30, 2010, when 52,419 fans watched Game 3 of the 2010 World Series against the San Francisco Giants. On May 20, 2016, the Rangers announced that they intend to move from Globe
Arlington Stadium Arlington Stadium was a baseball stadium located in Arlington, Texas, United States, located between Dallas and Fort Worth, Texas. It served as the home for the Texas Rangers (MLB) from 1972 until 1993, when the team moved into The Ballpark in Arlington (now Globe Life Park in Arlington), which has been the team's current home since 1994. The stadium was built in 1965 as Turnpike Stadium, a minor league ballpark seating 10,000 people named for the nearby Dallas-Fort Worth Turnpike (Interstate 30, also known as the Tom Landry Highway). The Fort Worth Cats of the Texas League moved
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inning, several hundred youths stormed the field, raiding it for souvenirs. One man grabbed first base and ran off with it. With no security in sight and only three bases, umpire crew chief Jim Honochick forfeited the game to the New York Yankees. During the off-season, improvements were made to Turnpike Stadium, which reopened as Arlington Stadium for the 1972 season. Meanwhile, ownership announced that the franchise would be renamed the Texas Rangers. The team played its first game on April 15, 1972, a 1–0 loss at the California Angels. The next day, the Rangers defeated the Angels 5–1 for
public displays from violent mob reaction. With the passage of the Volstead Act and the beginning of nationwide prohibition on January 16, 1920, their duties extended to scouting the border for tequila smugglers and detecting and dismantling the illegal stills that abounded along Texas's territory. One of the Rangers' highest-profile interventions during this period was taming Texas's oil boomtowns (beginning with Spindletop's discovery in 1901), which had developed into lawless territories. During the 1920s, martial law was decreed on several of these towns, such as Mexia and Borger; at others, like Desdemona, Wink, Ranger, Kilgore and Burkburnett, the situation was
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a half of the season in first place in the National League Central division. That was considered a disappointment due to hopes of reaching the World Series after signing free agent starting pitchers Clemens and Pettitte, and acquiring Beltrán weeks earlier. The 2004 Major League Baseball All-Star Game was the 75th playing of the midseason exhibition baseball game between the all-stars of the American League (AL) and National League (NL). The game was held on July 13, 2004 at Minute Maid Park in Houston, Texas, the Houston Astros' home stadium. The previous All-Star Game held in Houston was in 1986
Minute Maid Park Minute Maid Park, previously known as The Ballpark at Union Station, Enron Field, and Astros Field, is a ballpark in Downtown Houston, Texas, United States, that opened in 2000 to house the Houston Astros of Major League Baseball (MLB). The ballpark is Houston's first retractable-roofed stadium, and features a natural grass playing field. The ballpark was built as a replacement of the Astrodome, the first domed sports stadium ever built, which opened in 1965. It is named for beverage brand Minute Maid, a subsidiary of The Coca-Cola Company, which acquired naming rights in 2002 for $100 million
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when did houston move to the national league
Houston Astros The Houston Astros are an American professional baseball team based in Houston, Texas. The Astros compete in Major League Baseball (MLB) as a member club of the American League (AL) West division, having moved to the division in 2013 after spending their first 51 seasons in the National League (NL). The Astros have played their home games at Minute Maid Park since 2000. The Astros were established as the Houston Colt .45s and entered the National League as an expansion team in along with the New York Mets. The current name—reflecting Houston's role as the control center of
the new league the Continental League. Wanting to protect potential new markets, both existing leagues chose to expand from eight teams to ten. However, plans eventually fell through for the Houston franchise after the Houston Buffaloes owner, Marty Marion, could not come to an agreement with the HSA to sell the team. To make matters worse, the Continental League as a whole folded in August 1960. However, on October 17, 1960, the National League granted an expansion franchise to the Houston Sports Association in which their team could begin play in the 1962 season. According to the Major League Baseball
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when did the astros move to the american league
Houston Astros The Houston Astros are an American professional baseball team based in Houston, Texas. The Astros compete in Major League Baseball (MLB) as a member club of the American League (AL) West division, having moved to the division in 2013 after spending their first 51 seasons in the National League (NL). The Astros have played their home games at Minute Maid Park since 2000. The Astros were established as the Houston Colt .45s and entered the National League as an expansion team in along with the New York Mets. The current name—reflecting Houston's role as the control center of
the way that baseball was watched in Houston and around the league. On December 1, 1964, the team announced the name change from Colt .45s to "Astros." With Judge Roy Hofheinz now the sole owner of the franchise and the new venue complete, the renamed "Astros" moved into their new domed stadium, the "Astro"dome, in 1965. The name honored Houston's position as the center of the nation's space program; NASA's new Manned Spacecraft Center had recently opened southeast of the city. The Astrodome, coined the "Eighth Wonder of the World", did little to improve the home team's results on the
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the U.S. crewed space program—was adopted three years later, when they moved into the Astrodome, the first domed sports stadium. The Astros played in the NL from 1962 to 2012, first in the West Division from 1969 to 1993, followed by the Central Division from 1994 to 2012. The team was reclassified to the American League West from 2013 onward. While a member of the NL, the Astros played in one World Series in 2005, losing in four games to the Chicago White Sox. In 2017, they became the first franchise in MLB history to have won a pennant in
of discriminatory hiring practices regarding women and minorities, among other issues. This delayed MLB's approval process. During the summer of 2011, a frustrated Crane hinted that the delays might threaten the deal. In October 2011, Crane met personally with MLB Commissioner Bud Selig, in a meeting that was described as "constructive". On November 15, 2011, it was announced that Crane had agreed to move the franchise to the American League for the 2013 season. The move was part of an overall divisional realignment of MLB, with the National and American leagues each having 15 teams in three geographically balanced divisions.
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when 's the last time the houston astros won the pennant
both the NL and the AL, when they defeated the New York Yankees in the ALCS. They won the 2017 World Series against the Los Angeles Dodgers, winning four games to three, earning the team, and the state of Texas, its first World Series title. From 1888 until 1961, Houston's professional baseball club was the minor league Houston Buffaloes. Although expansion from the National League eventually brought an MLB team to Texas in 1962, Houston officials had been making efforts to do so for years prior. There were four men chiefly responsible for bringing Major League Baseball to Houston: George
of discriminatory hiring practices regarding women and minorities, among other issues. This delayed MLB's approval process. During the summer of 2011, a frustrated Crane hinted that the delays might threaten the deal. In October 2011, Crane met personally with MLB Commissioner Bud Selig, in a meeting that was described as "constructive". On November 15, 2011, it was announced that Crane had agreed to move the franchise to the American League for the 2013 season. The move was part of an overall divisional realignment of MLB, with the National and American leagues each having 15 teams in three geographically balanced divisions.
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when is the last time the astros went to world series
the U.S. crewed space program—was adopted three years later, when they moved into the Astrodome, the first domed sports stadium. The Astros played in the NL from 1962 to 2012, first in the West Division from 1969 to 1993, followed by the Central Division from 1994 to 2012. The team was reclassified to the American League West from 2013 onward. While a member of the NL, the Astros played in one World Series in 2005, losing in four games to the Chicago White Sox. In 2017, they became the first franchise in MLB history to have won a pennant in
both the NL and the AL, when they defeated the New York Yankees in the ALCS. They won the 2017 World Series against the Los Angeles Dodgers, winning four games to three, earning the team, and the state of Texas, its first World Series title. From 1888 until 1961, Houston's professional baseball club was the minor league Houston Buffaloes. Although expansion from the National League eventually brought an MLB team to Texas in 1962, Houston officials had been making efforts to do so for years prior. There were four men chiefly responsible for bringing Major League Baseball to Houston: George
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who does the houston astros play in the playoffs
As winners of their respective division, the Astros received a bye during the procession of the AL Wild Card Game, played between the wild card winners, New York Yankees and Minnesota Twins. The Astros were seeded #2 in the AL, the result of attaining the second-most wins in the league. Their first playoff game of 2017 was in the American League Division Series, versus the Boston Red Sox. It was the first time the Astros had faced the Red Sox in the postseason. The Astros played American League East division champion Boston Red Sox in the ALDS. In Game 1,
2018 Houston Astros season The 2018 Houston Astros season was the 57th season for the Major League Baseball (MLB) franchise in Houston, their 54th as the Astros, sixth in both the American League (AL) and AL West division, and 19th at Minute Maid Park. The Astros were the defending World Series champions, having won the 2017 World Series four games to three over the Los Angeles Dodgers. Houston began the season March 29 against the Texas Rangers and finished the season on September 30 against the Baltimore Orioles. They repeated as American League West champions and swept the Cleveland Indians
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where do the down east wood ducks play
Down East Wood Ducks The Down East Wood Ducks are a Minor League Baseball team of the Carolina League and the owned-and-operated Class A-Advanced affiliate of the Texas Rangers. They are located in Kinston, North Carolina. Established in 2017, the team plays its home games at Grainger Stadium, which opened in 1949 and holds 4,100 fans. The Rangers signed a 12-year contract with the city of Kinston to provide a team to play at Grainger Stadium which began in the 2017 season. Kinston has hosted farm clubs for eleven different major league franchises and one minor league club in its
August 22, the Rangers announced that they would indeed site an owned-and-operated High-A affiliate in Kinston for the 2017 season. The Astros would eventually announce their own stadium deal in Fayetteville, but with no suitable facility available until the 2019 season, the Astros temporarily placed their club at Campbell University as the Buies Creek Astros. Both clubs officially entered the Carolina League as expansion franchises, with their predecessor California League franchises terminated rather than relocated. During the Wood Ducks inaugural season in 2017 they were crowned co-champions of the Carolina League by defeating the Myrtle Beach Pelicans. Down East and
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when did the texas rangers go to the world series
in six games. In the 2010 World Series, the franchise's first, the Rangers fell to the San Francisco Giants in five games. They repeated as American League champions the following year, then lost the 2011 World Series to the St. Louis Cardinals in seven games. When the second Washington Senators moved to Minnesota in 1960 to become the Twins, Major League Baseball decided to expand a year earlier than planned to stave off the twin threats of competition from the proposed Continental League and loss of its exemption from the Sherman Antitrust Act. This new Senators team of the American
man grabbed first base and ran off with it. With no security in sight and only three bases, umpire crew chief Jim Honochick forfeited the game to the New York Yankees. The nation's capital went with out Major League Baseball for 33 years until the relocation of the National League's Montreal Expos who became the Washington Nationals. Prior to the 1972 season, improvements were made to Turnpike Stadium, which reopened as Arlington Stadium, in preparation for the inaugural season of the Texas Rangers. The team played its first game on April 15, 1972, a 1–0 loss at the hands of
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where do texas rangers play their home games
head six times. Arlington Stadium Arlington Stadium was a baseball stadium located in Arlington, Texas, United States, located between Dallas and Fort Worth, Texas. It served as the home for the Texas Rangers (MLB) from 1972 until 1993, when the team moved into The Ballpark in Arlington (now Globe Life Park in Arlington), which has been the team's current home since 1994. The stadium was built in 1965 as Turnpike Stadium, a minor league ballpark seating 10,000 people named for the nearby Dallas-Fort Worth Turnpike (Interstate 30, also known as the Tom Landry Highway). The Fort Worth Cats of the
over a decade. Years earlier, Charles O. Finley, the owner of the Kansas City Athletics, sought to relocate his baseball team to Dallas, Texas, but the idea was rebuffed and ultimately declined by the other AL team owners. Arlington's hole card was Turnpike Stadium, a 10,000-seat park which had been built in to house the Double-A Dallas-Fort Worth Spurs of the Texas League. Only minor excavations would be necessary to expand the park to accommodate major league crowds as it had been built to major league specifications. Vandergriff's offer of a multimillion-dollar down payment prompted Short to make the move
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the first team in Major League history to win three different divisions: National League West in 1980 and 1986, National League Central from 1997 to 1999 and 2001, and American League West in 2017. On September 29, the Astros won their 100th game of the season, the second time the Astros finished a season with over 100 wins, the first being in 1998. They finished 101–61, with a 21-game lead in the division, and faced the Red Sox in the first round of the AL playoffs. The Astros defeated the Red Sox three games to one, and advanced to the
American League Championship Series against the New York Yankees. The Astros won the ALCS four games to three, and advanced to the World Series to play against the Los Angeles Dodgers. The Astros defeated the Dodgers in the deciding seventh game of the World Series, winning the first championship in franchise history. The city of Houston celebrated the team's accomplishment with a parade on the afternoon of November 3, 2017. Houston's Independent School District gave the students and teachers the day off to watch the parade. On November 16, 2017 José Altuve was named the American League Most Valuable Player,
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