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0.461716 | b5c7f0337577403c8c2bd5449b562544 | The location of the study area. | PMC10169206 | 41598_2023_34641_Fig16_HTML.jpg |
0.417869 | 4c94dfff68b54cb6851d5058d0eda4b2 | Division and mining sequence diagram of an open pit mine. | PMC10169206 | 41598_2023_34641_Fig17_HTML.jpg |
0.50079 | 14de0e03491347df8a39eb325c71d369 | Cross section of an open pit mine. | PMC10169206 | 41598_2023_34641_Fig18_HTML.jpg |
0.536739 | 7c3fb7a113554a239d98c5f12d416b77 | Comparison between the used and actual coal prices in the multistep boundary optimization design process. | PMC10169206 | 41598_2023_34641_Fig19_HTML.jpg |
0.453938 | dbdb6432c68f47c1a49604b7fa07eb5e | Schematic diagram of sparrow population division of labour. | PMC10169206 | 41598_2023_34641_Fig1_HTML.jpg |
0.36613 | b3927d9d3cf14775ab7c924dd2da1e0e | The change trend of boundary and profit value during the coal price forecast period. | PMC10169206 | 41598_2023_34641_Fig20_HTML.jpg |
0.525557 | 2d5589092a9b489fbdabd99c53a4ea6c | Flow chart of the ISSA. | PMC10169206 | 41598_2023_34641_Fig2_HTML.jpg |
0.473902 | 604e271353074ffe8ae44599770b33e3 | SVR 2D schematic. | PMC10169206 | 41598_2023_34641_Fig3_HTML.jpg |
0.444318 | f7a2a4796e7f4eb894b21d936c3ec911 | ISSA–LSSVR process. | PMC10169206 | 41598_2023_34641_Fig4_HTML.jpg |
0.434265 | 0993a0d7f7a148ddac8443c41ff6efc3 | Comparison of coal pithead price and thermal coal price trend. | PMC10169206 | 41598_2023_34641_Fig5_HTML.jpg |
0.428328 | 7fd7cad163454eeda2a9ae5db9dbb7a6 | ISSA–SVR model prediction results. | PMC10169206 | 41598_2023_34641_Fig6_HTML.jpg |
0.560426 | 8091d09512c745b09f38458f7b2be324 | Plot of adaptation with number of iterations. | PMC10169206 | 41598_2023_34641_Fig7_HTML.jpg |
0.468727 | d8ed3aa5a7e24204908228424e437136 | The ARIMA model prediction flow chart. | PMC10169206 | 41598_2023_34641_Fig8_HTML.jpg |
0.493989 | 2dd3864f439245da9c7eb8025da1fe39 | Coal price ARIMA model prediction results. | PMC10169206 | 41598_2023_34641_Fig9_HTML.jpg |
0.473681 | 7f2579b24bbf4fca80d69876d17b03a1 | Transabdominal and sagittal ultrasound view demonstrating cervical pregnancy with empty endometrial cavity. | PMC10169242 | CRIOG2023-4725663.001.jpg |
0.430787 | 31b3d169274f421f9b041fd8113dcb65 | Transabdominal and sagittal ultrasound view demonstrating the Cook intracervical ripening balloon compressing the GS (arrow). | PMC10169242 | CRIOG2023-4725663.002.jpg |
0.495884 | 68c8b8ceaf8b495b94d7dc7d38d9efd1 | Transabdominal and sagittal ultrasound 12 weeks after removal of balloon demonstrating GS decreased to 1.4 cm. | PMC10169242 | CRIOG2023-4725663.003.jpg |
0.46197 | 249d09048ab541aea244b30129a89d98 | Scatter plot of FPG and HbA1c% values in 15,312 diabetes patients | PMC10169464 | 13098_2023_1077_Fig1_HTML.jpg |
0.510539 | 283db09183dd49f194c8d99bb078bbd3 | Comparison of GDI values in patients in the normal and high glycemic variability groups (Mann-Whitney U test) | PMC10169464 | 13098_2023_1077_Figd_HTML.jpg |
0.463507 | 2d6bc778118d4572a548dda75997b60f | A ROC curves of GDI, |2hPG—FPG|, and HbA1c% for screening high levels of glycemic variability. B ROC curve of GA/HbA1c for excluding high levels of glycemic variability | PMC10169464 | 13098_2023_1077_Fige_HTML.jpg |
0.447958 | 1d8d83a9a6774ebca5e0f781163a864c | Schematic presentation of sampling procedure for a study on quality of care for SAM management among caregivers of under-five children in selected public hospital in Addis Ababa, Ethiopia, 2022. Y12MCH, Yekatit 12 Hospital Medical College; ZMGH, Zewditu Memorial General Hospital; MIIGRH, Menelik the Second General Referral Hospital; TBGH, Tirunesh Beijing General Hospital. | PMC10169666 | fpubh-11-1089323-g0001.jpg |
0.454968 | 0a719ed3a62c4eff99b3fb7f76bc19ab | Innovativeness appraisals (n = 141) | PMC10169980 | 41669_2023_393_Fig1_HTML.jpg |
0.451459 | d81a757fb33d48ed8f65c19d76ab78c1 | Argyreiasubrotunda Q.R.Liu & M.L.Zhang, sp. nov. A stem with leaves and inflorescences B bract (outside) C bract (inside) D sepals from outer (left) to innermost (right) E opened corolla showing mid-petaline bands F opened corolla with stamens G pistil H fruit with persistent sepals I seed (adaxial surface) J seed (lateral surface). All drawn by Quan-Ru Liu from voucher specimens M. L. Zhang BNU2021YN074 (BNU!) (A–G), X. B. Guo BNU2021YN081 (BNU!) (H–J). | PMC10170312 | phytokeys-225-199_article-100646__-g001.jpg |
0.428646 | 698a45d185e44cfba2881b2d7d9b0f60 | Argyreiasubrotunda Q.R.Liu & M.L.Zhang, sp. nov. A plant habit B inflorescence C flower in frontal view D fruit with persistent sepals E seeds: adaxial surface (left); lateral surface (right). Scale bar: 5 mm. Photographs A–C, E by Mao-Lin Zhang, D by Xi-Bing Guo. | PMC10170312 | phytokeys-225-199_article-100646__-g002.jpg |
0.501349 | ede3e41b31fe43e2843ebd0ec5b35911 | Distribution of Argyreiasubrotunda in China. Drawn by Yi He. | PMC10170312 | phytokeys-225-199_article-100646__-g003.jpg |
0.438852 | d447334ad64346a284622f79e5d03dbc | Comparison of pollen morphology AArgyreiasubrotundaBA.wallichiiCA.marlipoensis. Scale bars: 20 μm. | PMC10170312 | phytokeys-225-199_article-100646__-g004.jpg |
0.41803 | 7a42c94e8d594452a47709cf15552313 | ArgyreiasubrotundaA opened corolla with 5 stamens B bract E inflorescence. A.wallichiiC opened corolla with 5 stamens D bract F inflorescence. | PMC10170312 | phytokeys-225-199_article-100646__-g005.jpg |
0.429816 | 16273a9065d844209ea76c70d67d7e77 | Knockdown of FPR2 promotes cell migration and invasion through the PI3K-AKT pathway. (A) Western blotting of FPR2, p-PI3K, PI3K, p-AKT and AKT in HTR8 cells transfected with si-FPR2 or si-NC in the presence or absence of LY294002 and densitometry quantification of western blots. (B) Gap closure and (C) Transwell assays of FPR2 silencing cells in the presence of LY294002. Scale bars=200 µm. Data are presented as mean ± SD obtained from at least three independent experiments. *P<0.05, **P<0.01. FPR2, formyl peptide receptor 2; p-, phosphorylated; si, small interfering; NC, negative control.. | PMC10170491 | mmr-27-06-12998-g00.jpg |
0.402637 | 4728c870e9c1494ca54a483fa32775ad | NHEJ pathway suppresses HR pathway inT. reesei. NHEJ starts with recognizing and binding the DSBs by the Ku70/80 complex, which serves as a scaffold to recruit repair enzymes Mus53(Lig4) to finish the DNA ends ligation. Because NHEJ pathway is dominant during DSB repair in eukaryotic organisms including T. reesei, the NHEJ defective strains, such as Δku70 and Δmus53, have been developed to increase the rate of HR in T. reesei | PMC10170752 | 12934_2023_2104_Fig1_HTML.jpg |
0.476231 | 547d7afad67549f8aa7f4bc4476c5042 | Strategies for synthesis of siRNA inT. reesei. (a) Identical sequences with target genes are transcribed in both directions under the control of a dual promoter to generate dsRNA. (b) The shRNA is generated by constructing a cassette in which the promoter drives the transcription of two inverted repeat sequences identical to the target gene with a spacer. (c) A complementary sequence to targeting mRNA is transcribed as antisense ssRNA by constructing a cassette in which the promoter drives a transcription of sequence from the antisense strand. The antisense ssRNA will pair with target mRNA to generate the dsRNA. The dsRNA as well as shRNA will be processed by ribonuclease Dicer to generate siRNA for RNAi induction | PMC10170752 | 12934_2023_2104_Fig2_HTML.jpg |
0.385216 | 9334ce1ce145445bbd1b8f6007c47a78 | Strategies for local promoter replacement. An artificial cassette was orderly assembled in vitro by four fragments containing 5’ flanking region, the pyr4 expression cassette (P and T represent promoter and terminator, respectively), Ptcu1 promoter, and ORF of the local gene. When an artificial cassette integrates into the correct loci of the genome, the local gene expression will be controlled by copper from the environment | PMC10170752 | 12934_2023_2104_Fig3_HTML.jpg |
0.507819 | 27f3e86cc10b4514b76129060b2c380e | Diagram of RIP process. Two haploid strains with different mating types are crossed. Between them, a strain (left) harboring an unlinked duplication (box) of the chromosomal fragment. For clarity, only two chromosomes are indicated. After fertilization, both copies of the strain harboring duplicated fragments are mutant by RIP during the dikaryon stage. Karyogamy and meiosis immediately follow and the four possible combinations (a-d) of chromosomes in progeny are shown. If the duplicated fragment derives from the target gene coding region, the target gene of two progenies (a-b) is inactivated | PMC10170752 | 12934_2023_2104_Fig4_HTML.jpg |
0.441395 | 7340ed4ec6634da4bf06d663747cdbf8 | Schematic diagram of the CRISPR/Cas9 system developed inT. reesei. (a) Two plasmids expressing NLS-Cas9 fusion protein and sgRNA were constructed, respectively, and were delivered together to cells. (b) The NLS-Cas9 protein and sgRNA were synthesized and assembled in vitro, and then they were transformed together into cells. (c) A plasmid expressing NLS-Cas9 fusion protein was constructed and delivered to cells. The sgRNA was prepared by in vitro transcription and transformed into host cells harboring the NLS-Cas9 expression cassette. The Cas9-sgRNA complex unwinds the double-stranded DNA (dsDNA) and the sgRNA binds to one of the DNA strands. Upon binding, the Cas9 nuclease cleaves both DNA strands upstream of the PAM sequence to form DSB, which is repaired either by the HR pathway or the NHEJ pathway | PMC10170752 | 12934_2023_2104_Fig5_HTML.jpg |
0.535617 | 32b6c5e4a53f493baa1e886456721036 | Decomposition of the problem into a hierarchy. | PMC10171687 | pone.0285452.g001.jpg |
0.553258 | 0374608997e84286b3902df2381ea1fb | Characteristics of the sample.(a) Age Distribution, (b) Educational qualification held, (c) Occupation. | PMC10171687 | pone.0285452.g002.jpg |
0.411374 | caa7cb9968ad4e7a9a4394f4bae78d29 | Propensity to vaccination for level of education. | PMC10171687 | pone.0285452.g003.jpg |
0.404432 | 5a12ee333ec0452185d85ac9dc18fa68 | Analysis of the propensity to vaccination for group of age.Each pie chart reports the percentage of people per age group (represented in different colors, as shown in the legend) that agree to each of the following statements: “I do not vaccinate”, “I would vaccinate after a few months”, “I would vaccinate after a few days”, and “I would vaccinate right away”. | PMC10171687 | pone.0285452.g004.jpg |
0.394468 | 10765fa98a06458690f34b1f082c5d6f | Relation between 5G and Covid-19 for level of education (express in absolute value). | PMC10171687 | pone.0285452.g005.jpg |
0.425793 | 26c51b07184a4452bf60f846bded02bf | Overall evaluation (blue), and partial evaluations based on economic (green) and healthcare criteria (red) for Italian regions. | PMC10171687 | pone.0285452.g006.jpg |
0.519309 | b4687c8538f44cabb540f5235d1ff81e | Italian regions evaluations.Light colors correspond to a high (positive) evaluation, dark colors correspond to a low (negative) evaluation. The regions are identified according to the following numbers: (1) Valle d–Aosta, (2) Piemonte, (3) Lombardia, (4) Trentino Alto Adige, (5) Friuli Venezia Giulia, (6) Veneto, (7) Emilia Romagna, (8) Liguria, (9) Toscana, (10) Marche, (11) Umbria, (12) Lazio, (13) Abruzzo, (14) Molise, (15) Campania, (16) Puglia, (17) Basilicata, (18) Calabria, (19) Sicilia, (20) Sardegna. (a) Map of the Italian regions, (b) Overall evaluation, (c) Partial evaluation based on healthcare criteria, (d) Partial evaluation based on economic criteria. | PMC10171687 | pone.0285452.g007.jpg |
0.433194 | 4c6ef3684bde4d22891f1f5071c9e117 | Overall evaluation (blue), and partial evaluations based on economic (green) and healthcare criteria (red) for Italian regions considering only respondents in the 18-25 age group. | PMC10171687 | pone.0285452.g008.jpg |
0.422794 | 239047f779c24df98074444dfaceb6e9 | Overall evaluation (blue), and partial evaluations based on economic (green) and healthcare criteria (red) for Italian regions considering only people who would not vaccinate. | PMC10171687 | pone.0285452.g009.jpg |
0.421148 | 498d5058c563415689d5e13099262d02 | Linear SCAP of the scalp, conformed by multiple grouped papules with central umbilication and crusted surface. | PMC10173062 | gr1.jpg |
0.392468 | 62d1d79a923847e0b2c8b3119f61fcac | (A) Red papillomatous projection with central ulceration in an erythematous background and polymorphic vessels in the periphery of the lesion (asterisk) (B) Another lesion with multiple ulcerations, whitish-yellow crusts (asterisk), and small white circles (arrow) on the periphery. | PMC10173062 | gr2.jpg |
0.500077 | 4fa736cb7bfd48db95d2ede4adef3159 | (A) Irregular papillary projections protruding into the lumen with plasmocytes in the core (Hematoxylin & eosin, 100×). (B) Cystic spaces are lined by two layers of glandular epithelium. Cells of the inner layer are columnar with oval nuclei, while in the outer layer, the cells are smaller, cuboidal, and have oval nuclei with scatty cytoplasm. Decapitation on the luminal surface can be noticed (↙) (Hematoxylin & eosin, 400×). | PMC10173062 | gr3.jpg |
0.440888 | 7163e5b4294b4bd58ff796433c977893 | Schematic illustration of the chemical structure of functionalized
NC. | PMC10173339 | ao2c07033_0002.jpg |
0.438175 | 74ce2f2fcaf948ccbdceabd9ae0fd8af | FTIR spectra for neat NC and chemically functionalized NC. Inset:
zoomed spectral range of 1200–1700 cm–1. | PMC10173339 | ao2c07033_0003.jpg |
0.458561 | b2bf268e13fa4173bf1f36346355989a | Surface elemental analysis of the NC-based nanomaterials by XPS
survey. | PMC10173339 | ao2c07033_0004.jpg |
0.420023 | 416dcd9d253847b0a5d9a43cfdf97b0b | High-resolution
C1s spectral deconvolution from XPS of neat NC
and chemically functionalized NC. | PMC10173339 | ao2c07033_0005.jpg |
0.59488 | 35befbb1896f4590bdc2205b1fae7d7e | TGA curves
and DTG profiles (inset) of neat NC and chemically functionalized
NC. | PMC10173339 | ao2c07033_0006.jpg |
0.455295 | 862d75c79458439f9de2a79bfaf80445 | DSC curves registered for the ELO-NC formulation curing
process. | PMC10173339 | ao2c07033_0007.jpg |
0.416784 | df7f30badef14f4fba4158adb41134ba | Graphical representation for storage modulus
and tan δ
(inset) curves for ENC nanocomposites. | PMC10173339 | ao2c07033_0008.jpg |
0.571233 | 23f2d41ffed54652b3a986b517d74e83 | TGA profiles for ENC
nanocomposite materials. | PMC10173339 | ao2c07033_0009.jpg |
0.510086 | 2a9a8a91139d4098b6faeb3dcb082baf | Surface characteristics for ELO-NC nanocomposite materials. | PMC10173339 | ao2c07033_0010.jpg |
0.486992 | 18330000d481460d93bef5c98bf84394 | SEM micrographs
for ELO nanocomposites with 3% nanocellulose. | PMC10173339 | ao2c07033_0011.jpg |
0.413337 | d00a7791f1c74175a6e5407b6ddab9df | MRPL12 interacts with ANT3 specifically(A) Mass spectrometry assay. The criteria for identifying candidate binding partners are described in the results. The total scores of candidate proteins were calculated by analysis software and are listed in descending order.(B) Interaction of MRPL12 and ANT3 in HK-2 cells visualized by the Duolink@ proximity ligation assay. Scale bars = 25 μm.(C) Duolink@ proximity ligation assay of MRPL12 and ANT1/2 in HK-2 cells. Scale bars = 25 μm.(D) Coimmunoprecipitation assay of MRPL12 and ANT3 in HK-2 cells.(E) Coimmunoprecipitation assay of MRPL12 and ANT1/2 in HK-2 cells.(F) Coimmunoprecipitation assay of MRPL11 and ANT3 in HK-2 cells.(G) Duolink@ proximity ligation assay of MRPL11 and ANT3 in HK-2 cells. Scale bars = 25 μm. The independent experiments above were performed in triplicate. | PMC10173734 | gr1.jpg |
0.393352 | 3059fb5e172144d7a1d263b9fc20791d | MRPL12 influences the opening of MPTP via ANT3(A–F) qRT‒PCR and Western blotting were performed to detect MRPL12 and ANT3 expression in HK-2 cells transfected with MRPL12-silencing shRNA or MRPL12-overexpressing plasmids.(G and H) The opening of the mPTP in HK-2 cells was detected by a CoCl2-calcein fluorescence quenching assay. After CoCl2 quenching, calcein fluorescence decreased, indicating MPTP pore opening. Scale bars = 25 μm.(I and J) Quantification of calcein fluorescence was performed using Image J and is shown in the histogram. The independent experiments above were performed in triplicate. The differences were analyzed by Student’s t test. Data are presented as the mean ± SD, ∗∗∗∗p<0.0001. | PMC10173734 | gr2.jpg |
0.432791 | 09493d1a7bf04b1c811cb725469d514b | MRPL12 manipulates MPTP opening by influencing ANT3 conformation(A) Domain structure of MRPL12 FL and MRPL12 DMs. MRPL12 DM1: 45–198 amino acids; MRPL12 DM2: 1–45 and 91–198 amino acids; MRPL12 DM3: 1–90 and 129–198 amino acids; MRPL12 DM4: 1–128 amino acids.(B) FLAG and rabbit immunoglobulin (IgG, used as a negative control) immunoprecipitations (IP) of lysates from 293 T cells cotransfected with ANT3-FLAG and MRPL12 FL-HA or the indicated MRPL12 DMs-HA. Immunoprecipitates were immunoblotted (IB) either with HA or FLAG antibodies to examine deletion mutants of MRPL12 or ANT3, respectively.(C and E) The opening of the MPTP in HK-2 cells was detected by a CoCl2-calcein fluorescence quenching assay. After CoCl2 quenching, calcein fluorescence decreased, indicating MPTP pore opening. Scale bars = 25 μm.(D and F) Quantification of calcein fluorescence was calculated by Image J and is shown in the histogram.(G) Western blotting for OXPHOS components in MRPL12 FL-overexpressing or MRPL12 DM3-overexpressing HK-2 cells. The independent experiments above were performed in triplicate. The differences were analyzed by Student’s t test. Data are presented as the mean ± SD, ∗∗p<0.01, ∗∗∗p<0.001 and ∗∗∗∗p<0.0001. | PMC10173734 | gr3.jpg |
0.471562 | 84838bf03b264b3792a12859fdc3edf6 | MRPL12 involves in mitochondria-mediated apoptosis in an ANT3-dependent manner(A and B) Apoptosis in HK-2 cells was detected by flow cytometry analysis. The results of flow cytometry analysis were quantified.(C and D) Apoptosis in HK-2 cells was detected by flow cytometry analysis. Cells transfected with MRPL12 FL-overexpressing plasmid or MRPL12 DM3-overexpressing plasmid were treated with 5 μM ATR. The results of flow cytometry analysis were quantified.(E and F) Release of cyt-C from the mitochondria to the cytoplasm in HK-2 cells. Cells were fractionated into the cytoplasm and the mitochondria. Cyt-C protein levels were assessed by Western blot analysis.(G and H) The release of cyt-C from the mitochondria to the cytoplasm in HK-2 cells was assessed by Western blot analysis. Cells transfected with MRPL12 FL-overexpressing plasmid or MRPL12 DM3-overexpressing plasmid were treated with 5 μM ATR. The independent experiments above were performed in triplicate. The differences were analyzed by Student’s t test. Data are presented as the mean ± SD, ∗∗∗p<0.001 and ∗∗∗∗p<0.0001. | PMC10173734 | gr4.jpg |
0.394496 | 68bddce0cd7448aaa2642a4c7b165025 | The MRPL12/ANT3 interaction is diminished in I/R-injured kidneys and H/R-treated HK-2 cells(A and E) Coimmunoprecipitation with endogenous proteins indicated that MRPL12 physically interacted with ANT3. HK-2 cells were treated with H/R or left untreated. Cell lysates were immunoprecipitated with normal IgG, MRPL12 (A), or ANT3 (E) antibody. The immunoprecipitates were immunoblotted (IB) with MRPL12 and ANT3 antibodies. The interaction between MRPL12 and ANT3 was diminished by H/R treatment.(B, C, F, and G) Quantifications of MRPL12 (B, F) and ANT3 (C, G) expression as shown in A and E, respectively.(D and H) Quantifications of ANT3 immunoprecipitated with MRPL12 (D) and of MRPL12 immunoprecipitated with ANT3 (H), as shown in A and E, respectively. The coimmunoprecipitated proteins were normalized to β-actin.(I) Interaction of MRPL12 and ANT3 in HK-2 cells visualized by the Duolink@ proximity ligation assay. Scale bars = 25 μm.(J and K) Renal function of mice was evaluated by serum creatinine (sCr) and blood urea nitrogen (BUN).(L–O) HE staining for patients and mice with AKI compared with controls. Scale bars = 50 or 100 μm. Renal tubule injury was quantitatively analyzed.(P and Q) Representative images of immunohistochemical staining for MRPL12 and ANT3 expression in the human renal cortex. Scale bars = 100 μm.(R) Interaction of MRPL12 and ANT3 in the human renal cortex visualized by the Duolink@ proximity ligation assay. Scale bars = 25 μm. The independent experiments above were performed at least in triplicate. The differences were analyzed by Student’s t test. Data are presented as the mean ± SD, ∗∗p<0.01, ∗∗∗p<0.001 and ∗∗∗∗p<0.0001. | PMC10173734 | gr5.jpg |
0.422989 | dc6a93a988eb46f198b2ffd090efab91 | MRPL12 attenuates MPTP opening by interacting with ANT3 under H/R conditions(A) HK-2 cells transfected with MRPL12 FL-overexpressing plasmid were subjected to H/R treatment, and the interaction of MRPL12 and ANT3 was visualized by a Duolink@ proximity ligation assay. Scale bars = 25 μm.(B) Mean intensity was calculated by Image J and is shown in the histogram.(C) HK-2 cells transfected with empty vector, MRPL12 FL-overexpressing plasmid or MRPL12 DM3-overexpressing plasmid were subjected to H/R treatment. The opening of the MPTP in HK-2 cells was detected by a CoCl2-calcein fluorescence quenching assay. Scale bars = 25 μm.(D) Quantification of calcein fluorescence was performed using Image J and is shown in the histogram.(E) HK-2 cells transfected with scramble shRNA or MRPL12-silencing shRNA were subjected to H/R treatment. The opening of the MPTP in HK-2 cells was detected by a CoCl2-calcein fluorescence quenching assay. Scale bars = 25 μm.(F) Quantification of calcein fluorescence was performed using Image J and is shown in the histogram. The independent experiments above were performed in triplicate. The differences were analyzed by Student’s t test. Data are presented as the mean ± SD, ∗∗p<0.01, ∗∗∗p<0.001 and ∗∗∗∗p<0.0001. | PMC10173734 | gr6.jpg |
0.417153 | b1f622fad9814d1195d9c1db5550a901 | MRPL12 alleviates mitochondria-mediated apoptosis by interacting with ANT3 under H/R conditions(A and B) The release of cyt-C from the mitochondria to the cytoplasm in HK-2 cells was assessed by Western blot analysis. HK-2 cells transfected with MRPL12-silencing shRNA were subjected to H/R treatment.(C and D) Apoptosis in HK-2 cells was detected by flow cytometry analysis. HK-2 cells transfected with MRPL12-silencing shRNA were subjected to H/R treatment. The results of flow cytometry analysis were quantified.(E and F) The release of cyt-C from the mitochondria to the cytoplasm in HK-2 cells was assessed by Western blot analysis. HK-2 cells transfected with empty vector, MRPL12 FL-overexpressing plasmid or MRPL12 DM3-overexpressing plasmid were subjected to H/R treatment.(G and H) Apoptosis in HK-2 cells was detected by flow cytometry analysis. HK-2 cells transfected with empty vector, MRPL12 FL-overexpressing plasmid or MRPL12 DM3-overexpressing plasmid were subjected to H/R treatment. The results of flow cytometry analysis were quantified. The independent experiments above were performed in triplicate. The differences were analyzed by Student’s t test. Data are presented as the mean ± SD, ∗p< 0.05, ∗∗p<0.01, ∗∗∗p<0.001 and ∗∗∗∗p<0.0001. | PMC10173734 | gr7.jpg |
0.369801 | 27e892fe65c848508790b5f067bca522 | Two screenshots of the virtual reality interface for decision-making used during the emergency public health training scenarios show what the training participant sees. Background setting was captured separate from filming with an actor and was produced for the virtual reality format by coauthors (Foundry 45). *The person depicted is not a patient and the screenshot was taken with the actor’s knowledge and consent for publication. | PMC10173982 | bmjopen-2022-063527f01.jpg |
0.536047 | c561bedc6263480d9af1ed1c0e9efa0e | Inductive and deductive codes with associated definitions and examples applied to participant feedback during qualitative analysis. TAM, Technology Assessment Model. | PMC10173982 | bmjopen-2022-063527f02.jpg |
0.449968 | d3c8593814634a2bb84bfb1af960f1ba | Graphic representation of the Extended Technology Acceptance Model (TAM2) used to predict user beliefs contributing to future use of a technology (adapted from model presented in Venkatesh and Davis20). VR, virtual reality. | PMC10173982 | bmjopen-2022-063527f03.jpg |
0.448076 | 0cd20fd3166c4641bd8ca829ac97a520 | Jerry Brody in the lab in Boston University Pulmonary Center. Courtesy of Kalman Zabarsky/Boston University Photography. | PMC10174165 | rcmb.2023-0044EDf1.jpg |
0.477798 | 06ff954dbce2448092feeedcfcd6b276 | Number of authors identified at different stages. | PMC10174437 | froh-04-1059023-g001.jpg |
0.547744 | 75643fb078354c0cb2b48dd078ea786c | Schematic representation of the gene structure of p63. (A) The human p63 gene is located on chromosome 3q27 and spans over 250 kb, comprising 14 exons. Alternative splicing generates five isoforms (α, β, γ, δ, and ε), which differ in their C-terminus. The TAp63 isoforms, which contain a trans-activating domain (TAD), are encoded by exons 1, 2, and 3. (B) While ΔNp63 isoforms lack the TAD, TAp63 and ΔNp63 share a DNA binding domain (DBD), oligomerization domain (OD), sterile alpha domain (SAM), and a transactivation inhibitory domain (TID) in the C-terminal region. | PMC10174455 | fonc-13-1116061-g001.jpg |
0.497116 | 0acd9a17a0ae4918831c18dd3513ad09 | The function of mutated p53. (A) In normal cells, MDM2 plays an important role in regulating apoptosis. MDM2 binds to ΔNp63 and promotes its entry into the cytoplasm for degradation via proteasome, which can be blocked by the drug Leptomycin B (63). (B) In tumor cells, mut-p53 behaves in a prion-like behavior, not only possessing “seeding” ability and spreading to other cells, but also forming amyloid aggregates with TAp63 and wt-p53, leading to inactivation and promoting cell proliferation. However, MDM2 can block the aggregation of mut-p53, prevent mut-p53 from binding to TAp63, and alleviate mut-p53-related suppression to TAp63 (13, 64). (Created with Biorender.com). | PMC10174455 | fonc-13-1116061-g002.jpg |
0.394854 | 7a849d04275e44c6ac2fd2a4706a9fed | TAp63 and ΔNp63 exert different roles in response to chemotherapy. The TAp63 isoform is frequently associated with tumor suppression involved in cell cycle arrest, apoptosis, and DNA repair. In contrast, the ΔNp63 isoform serves as an oncogene, repressing proapoptotic genes, increasing chemotherapeutic resistance, and inducing cell proliferation. | PMC10174455 | fonc-13-1116061-g003.jpg |
0.439202 | f2a10f068fc74080b136f06bafa73467 | Model of p53 and p63 in response to DNA damage. (A) TAp63 and p53 induce apoptosis pathways to activate the mitochondrial cascades, and ΔNp63 is phosphorylated at S385G (p-ΔNp63S385G) by ATM and degraded following DNA damage. (B) The modular structure of ΔNp63 with putative phosphorylation sites. The arrows indicate the newly identified phosphorylation sites for MAPK (T187/T207), ATM (S385), CDK2 (T397), and p70s6K (S466) kinases (75, 105, 106). | PMC10174455 | fonc-13-1116061-g004.jpg |
0.504344 | 6efeb60377f74edfb6fc3e23c5ff634b | Schematic view of the overall work process. | PMC10174510 | pone.0285608.g001.jpg |
0.403442 | 2275f6afac964bfcbe06518ecc60fab8 | The data preparation process.CBCT images were generated by masking out the background signal noise (a). MDCT images were resampled to match the resolution of the CBCT images and then prepared using region-of-interest (ROI) masking and a two-step registration process utilizing affine and non-rigid registration to match the CBCT images (b). The final set of CBCT and MDCT image pairs was used for training and testing (c). CBCT, cone-beam computed tomography; MDCT, multidetector computed tomography. | PMC10174510 | pone.0285608.g002.jpg |
0.430621 | 48c17b73a4184cd08f7d1ac62f8f57a9 | Schematic of COMPUNet (multi-planar 2.5D U-Net), which comprises three single-planar 2.5D U-Nets.(a) The architecture of a single-planar 2.5D U-Net with a ResNet-34 encoder and (b) attention modules. xl: input features, α: attention coefficients, g: gating signal collected from a coarser scale. | PMC10174510 | pone.0285608.g003.jpg |
0.426982 | d98ed23176ea4c90beed55b24e5dc97f | Quantitative evaluation through an ablation study.NRMSE (a), SSIM (b), and MAE (c) for comparisons between the original (oCBCT) and predicted CBCT (pCBCT), showing that the best-performing model was the proposed model compared to Model 1 and Model 2. (* p < 0.005). | PMC10174510 | pone.0285608.g004.jpg |
0.450577 | 60dd445aaa29411fb80b8eeb25041bdb | The trabecular bone pattern (arrow) in the same image slides.The fine bone details are best preserved in the predicted CBCT of the proposed model, COMPUNet, compared to that of Model 1 and Model 2. | PMC10174510 | pone.0285608.g005.jpg |
0.473603 | f504b4b968f54bc88709da7c78aef427 | Mean scores of individual items in the clinical CBCT evaluation chart.Items for the artifacts and noise criteria showed improvements in the pCBCT images, while those for the resolution criterion improved less. | PMC10174510 | pone.0285608.g006.jpg |
0.435666 | 64dcd96c35714ac0a70171d2fad03a1d | Original CBCT with an overall image grade of poor and the corresponding predicted CBCT image.(a) The maxilla in an axial view (b), the anterior teeth region in a sagittal view, and (c) the temporomandibular region in a parasagittal view show reduced artifacts and noise in the COMPUNet CBCT compared to the original CBCT images. | PMC10174510 | pone.0285608.g007.jpg |
0.413046 | 86a9899aea7a4fa29e464ed75d0e8478 | Distribution of overall image quality evaluation grades.The proportion of CBCT with poor grades decreases (sky blue) and those with good grades increases (dark blue) in the predicted CBCT (pCBCT) compared to the original CBCT (oCBCT) for both observers. | PMC10174510 | pone.0285608.g008.jpg |
0.430901 | 774d2d34163049f79e20dbcdc6226829 | A) January 2021 Eruption of left lower extremity (LLE) ulcers during his international trip post his bike accident. B) One month later (February): New linear lesions on right (the nontraumatized) lower extremity (RLL). C) Three months later (April): Reemergence of ulcers with linear streaks of alopecia of LLE after second treatment of IVIG. D) Four months later (May): return of postweeping lesions on RLL after third treatment of Intravenous Immunoglobulin. | PMC10174739 | pg9-4-e277-g001.jpg |
0.460367 | 4d424cf956d742e1a3aedfffd635cbd4 | Biopsychosocial model of pain and illness as relates to our patient. | PMC10174739 | pg9-4-e277-g002.jpg |
0.379325 | c2e42be8d39044c6a7017a8f21de4e7c | First-line monitoring. DAP: Diastolic arterial pressure; MAP: Mean arterial pressure; PPV: Pulse pressure variation; SAP: Systolic arterial pressure. | PMC10175734 | gr1.jpg |
0.435362 | 1280d3892db74ed0bc0470f0a3c26cf6 | Parameters derived from central venous catheterization. CVP: Central venous pressure; Hb: Hemoglobin; PCO2 gap: Veno-arterial difference of CO2 pressure; RV: Right ventricular; ScVO2: Saturation of central venous oxygen saturation. | PMC10175734 | gr2.jpg |
0.395657 | aa30ec8dde6d499384fc10d414be42ea | Advanced hemodynamic monitoring. CFI: Cardiac function index; GEF: Global ejection fraction; MPAP: Mean pulmonary arterial pressure; PCO2 gap: Veno-arterial difference of CO2 pressure; PCWP: Pulmonary capillary wedge pressure; SVO2: Venous oxygen saturation. | PMC10175734 | gr3.jpg |
0.457658 | 6b508487a7224a35abade42189f97d67 | a OCT: optic disc oedema b OCT: macular degeneration c Pure tone audiogram: bilateral severe sensorineural hearing loss | PMC10176949 | 12886_2023_2966_Fig1_HTML.jpg |
0.466545 | 85af732dff2d4ccbbf72b8064dc9f4cf | Different biological effects of autophagy in gliomas are schematically identified. | PMC10177137 | cancers-15-02622-g001.jpg |
0.403117 | 5be40c24f6ce4e15be8cfa0f10d06221 | The role of the most relevant autophagy-involved agents in gliomas. | PMC10177137 | cancers-15-02622-g002.jpg |
0.466792 | 1ba8608bd75745b9bc4d688fec5a2b53 | Evaluation of seizure onset following CCI injury: (A) Control cortical impact (CCI) injury was induced using either a 2.0 mm or 2.5 mm impactor depth over the right parietal cortex of male adult CD1 mice on day 0. Continuous 24/7 EEG and video recording was performed at 2–4 months post-injury. (B) EEG electrode implantation was performed utilizing a bipolar montage composed of two recording electrodes (ipsilateral and contralateral to injury), one ground electrode (green), and two anchor screws to improve retention. (C) EEG readings displayed generalized seizures with typical interictal spikes, seizure activity, and post-seizure depression. (D) CCI injury was performed on 41 mice (21 at 2.5 mm depth and 20 at 2.0 mm depth) and 12 shams. We observed electrographic and behavioral seizures in 15 CCI-injured and 0 sham-injured mice. | PMC10177146 | cells-12-01248-g001.jpg |
0.552048 | f7dfc74383a74481ada0b951c8a53c86 | Histological comparison of injury severity in CCI-injured mice: (A–D) Cresyl violet acetate staining of the serial coronal section of the murine brain from anterior to posterior, encompassing the brain lesion or sham. Based on the quantification of the cavity volume, and hippocampal displacement, there were 4 categories: Sham (A), severe (B), moderate/severe (C), and moderate (D) injury based on hippocampal pathology. Centered in each coronal section is a magnified micrograph of the hippocampus. Scale bar = 150 μm. (E) Quantified data displaying lesion volume (mm3) based on the four categories of histopathology. (F) Whole-brain images showing the gross pathology of cavitation induced by unilateral CCI injury between 2.5 mm depth (top panel) and 2.0 mm depth (bottom panel). Total n = 15 receiving 2.0 mm depth, n = 13 receiving 2.5 mm depth, and n = 8 sham, all of which were processed for Nissl staining and stratified accordingly. | PMC10177146 | cells-12-01248-g002.jpg |
0.429261 | e080d3f0317244e19f54830c3b9c6848 | PTE+ mice show increased aberrant migration of DCX+/Prox1+ cells in the dentate gyrus: (A) Representative max z-projected confocal image of the contralateral PTE− dentate gyrus (D,G), showing Prox1 and DCX immunofluorescence. (B–G) High-magnification max z-projected confocal image at four months in: PTE− (B–D) and PTE+ (E–G) ipsilateral DG. Prox1 and Prox1/DCX double-labeled cells were observed in the upper two-thirds of the DG (blue arrows) and in the hilus (white arrows). (H) Quantified graph showing that PTE+ mice display greater increase in the number of Prox1+/DCX+ cells compared to PTE− mice (p = 0.008). (I) Quantified graph showing a significant increase in the number of Prox1+ cells in the ipsilateral hilus of CCI-injured mice compared to sham mice (p < 0.0001). ** p < 0.01; *** p < 0.001; **** p < 0.00001. One-way ANOVA with Bonferroni post hoc correction; n = 5–9/group. ns = not significant. | PMC10177146 | cells-12-01248-g003.jpg |
0.432208 | 48d97256d8144787b71610c69bc9aaf8 | PTE+ mice display altered c-Fos in the dentate gyrus: (A) Stereological quantification of c-Fos-positive cells (a neuronal activation marker) in the contralateral and ipsilateral DG. Injury induced an increase in the number of c-Fos-expressing neurons relative to sham, regardless of PTE status (PTE− p = 0.02; PTE+ p = 0.002). (B) Quantified graph showing no change in contralateral hilar c-Fos; however, PTE+ (p = 0.0001) and PTE− (p = 0.02) are significant compared to sham in the ipsilateral hilus. PTE+ mice displayed a greater increase in c-Fos compared to PTE− mice (p = 0.03). (C–E) Representative max z-projection of the dentate gyrus from sham (C), PTE− (D), and PTE+ (E) mice stained with DAPI in blue and c-Fos in green. * p < 0.05; ** p < 0.01; **** p < 0.00001. One-way ANOVA with Bonferroni post hoc correction; scale bar = 100 µm; n = 5–9/group. ns = not significant. Scale in H = 100 μm. | PMC10177146 | cells-12-01248-g004.jpg |
0.424289 | fc94348fc4a546bab3c40ccc0e7af391 | PTE+ mice show altered neuronal composition in the hilus: (A) Quantified data showing that PTE+ mice displayed a trend towards reduced overall numbers of NeuN-positive cells in the ipsilateral hilus, increased numbers of Prox1/NeuN double-labeled granule cells (p = 0.005), and reduced numbers of Prox1-negative, NeuN-positive inhibitory neurons (p = 0.0001) compared to sham mice. A significant reduction in Prox1−/NeuN+ cells in PTE+ mice was observed compared to PTE− mice (p = 0.04). (B) Quantified data showing a reduction in the overall numbers of NeuN+ cells in the contralateral hilus of PTE+ mice compared to sham mice (p = 0.004), as well as a reduction in Prox1-/NeuN+ inhibitory neurons in CCI-injured PTE+ (p = 0.0001) and PTE− (p = 0.01) mice compared to sham mice. (C–E) Representative max z-projected confocal images of Prox1 (green) and NeuN (red) in the PTE− contralateral, (F–H) PTE− ipsilateral, (I–K) PTE+ contralateral, and (L–N) PTE+ ipsilateral hippocampus. (O) Proportion of Prox1+/NeuN+ granule cells/total NeuN vs. Prox1−/NeuN+ inhibitory neurons/total NeuN in the ipsilateral hilus of sham, PTE−, and PTE+ mice. (P) Similar proportions displayed for the contralateral hilus. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.00001. One-way ANOVA with Bonferroni post hoc correction; scale bar = 100 µm; sham n = 5; PTE− n = 5; PTE+ n = 9. ns = not significant. Scale in low mag = 100 μm and high mag = 20 μm. | PMC10177146 | cells-12-01248-g005.jpg |
0.432755 | c105422641a84e8e884d339ae46cce25 | Alterations in hilar astrocyte morphology show distinct changes after CCI injury and reduced branching in PTE+ mice: (A) Quantified data displaying the ratio of hilar astrocyte coverage. CCI induced an increase in astrocytic coverage in the ipsilateral hilus of PTE− (p = 0.03) and PTE+ mice (p = 0.02) compared to the corresponding contralateral hemisphere. (B–D) Morphological changes assessed using Imaris software analysis revealed no significant differences in sphericity (B) or prolation (C). Ipsilateral hilar astrocytes in PTE+ (p = 0.003) and PTE− (p = 0.004) mice showed a reduction in the oblate index (D). (E,F) Representative 3D confocal max z-projected images from PTE− and PTE+ hippocampi, respectively. (G) Sholl analysis comparing the ipsilateral hemispheres of sham, PTE +, and PTE− animals. PTE+ astrocytes showed a reduction in branching within 1 and 6 μm from the cell soma compared to PTE− astrocytes (p < 0.05), and within 4 to 15 μm compared to sham astrocytes (p < 0.05). Astrocytes from PTE+ mice had reduced branching compared to those from sham mice within 2 to 12 μm from the soma (p < 0.05). (H) A 3D graphical representation of hilar astrocytes in Imaris, displaying an oblong shape and reduced cell processes in injured mice compared to sham mice. * p < 0.05; ** p < 0.01. One-way ANOVA with Bonferroni post hoc correction; n = 4–8/group. ns = not significant. Scale in H = 2.5 μm; E-F = 20 μm. | PMC10177146 | cells-12-01248-g006.jpg |
0.451013 | 294605f4033e4ad3bbdd0ff17342b0a4 | Transcriptomic analysis of hippocampal astrocytes demonstrates key differences in PTE+ mice: RNA sequencing was performed on purified astrocytes from the hippocampus. (A) Venn diagram DEGs between sham and injured mice in the contralateral hippocampus. (B) Venn diagram showing unique DEGs between comparisons in the ipsilateral hippocampus. (C,D) GO circle plots showing the top 10 gene ontology enrichment terms in PTE− vs. PTE+ astrocytes from the hippocampus. These include GO terms associated with cellular response to hypoxia, cognition, and response to interferon-gamma. (E) Top 5 up- and downregulated genes in the contralateral and (F) ipsilateral PTE+ astrocytes compared to PTE− astrocytes. Contralateral: n = 5 sham and PTE+; n = 10 PTE−. Ipsilateral: n = 5 sham, n = 4 PTE+, and n = 8 PTE−. (G–I) Representative micrographs of the PTE+ ipsilateral hilus, (J–L) PTE+ contralateral hilus, and (M) PTE− ipsilateral hilus, immunostained against CST3, GFAP, and DAPI. (H,I) Magnified view of the hilus, showing co-labeling of CST3/GFAP astrocytes (arrowheads). Single-astrocyte micrographs reveal detailed co-localization of stained proteins in the soma of astrocytes. (N) Stereological cell counts of CST3+ cells and CST3/GFAP double-positives, showing no difference in the contralateral hemisphere of PTE+ compared to PTE−. (O) Ipsilateral hilus showing increased total numbers of CST3 (* p = 0.03) and CST3/GFAP (* p = 0.03) cells in PTE+ mice. CL = contralateral, IL = ipsilateral. | PMC10177146 | cells-12-01248-g007.jpg |
0.43162 | 2119a3cb6b8b494dba31fd9b6be494e1 | Characteristics of neoplasms. SCC—squamous cell carcinoma; BCC—basal cell carcinoma. | PMC10177333 | cancers-15-02464-g001.jpg |
0.432018 | b99ac56d7ce24650a636747d40ea4da2 | (A) Biopsies taken upon suspicious skin changes; (B) resection defect after tumor-free resection margins reached; (C) first-step reconstruction of nasal inner lining with free radial forearm flap; (D) second-step reconstruction with nasal alar reconstruction by autologous cartilage graft and (E) pedicled paramedian forehead flap; (F) follow-up result 18 months postoperatively. | PMC10177333 | cancers-15-02464-g002.jpg |
0.416232 | 6bfb0db6b87748dca5ac5a8093b75106 | Mediolateral view of the left upper leg (left side) and the right distal lower arm (right side). | PMC10177558 | animals-13-01540-g0A1.jpg |
0.41034 | d3c39f390315485cbbb6caf175b20d1a | Densities (g/mL) of Mucor cultures during 14-day aerobic cultivation at 30 °C and 200 rpm agitation in 100 mL yogurt acid whey. The markers show the means of biological triplicates, and the error bars refer to one standard error from the mean. MC = M. circinelloides; MG = M. genevensis; +E = with lactase addition; NH = without lactase addition. | PMC10177860 | foods-12-01784-g001.jpg |
0.480331 | 1a05bee179cc4f2fb33307160e193b7d | Changes in biochemical oxygen demand during 14-day aerobic cultivations of Mucor species at 30 °C and 200 rpm agitation in 620 mL yogurt acid whey (YAW). The bars show the means of biological triplicates, and the error bars refer to one standard error from the mean. On each day, the bars denoted with different letters are significantly different from each other. MC = M. circinelloides; MG = M. genevensis; +E = with lactase addition; NH = without lactase addition. | PMC10177860 | foods-12-01784-g002.jpg |
0.358709 | 3d0f76f4a4ab46febad91499da7de29a | The changes in pH during the 14-day aerobic cultivations of Mucor species at 30 °C and 200 rpm agitation in 100 mL yogurt acid whey. The markers show the means of biological triplicates, except for MCNH on day 12 where an outlier was removed. The error bars refer to one standard error from the mean. MC = M. circinelloides; MG = M. genevensis; +E = with lactase addition; NH = without lactase addition. | PMC10177860 | foods-12-01784-g003.jpg |
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