dedup-isc-ft-v107-score
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0.452514 | 5af31e08d98145318d08311d13b91736 | PRISMA flowchart of the scientific literature search and study selection. Data added to the PRISMA template (from Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ 2021;372:n71) under the terms of the Creative Commons Attribution License. n: number of references | PMC10159312 | SNI-14-124-g003.jpg |
0.403221 | a52bcdcd246b435fb1d4c972fa230ca5 | Flow diagram of studies searched in this meta-analysis. | PMC10159347 | pone.0285197.g001.jpg |
0.474215 | 99f514681a604fe2b9b4510ecf7f1dea | Graphs of risk of bias for studies. | PMC10159347 | pone.0285197.g002.jpg |
0.384302 | 00a09ec1f08943948a04cbbfa6167b7f | Quality assessment for risk of bias for studies. | PMC10159347 | pone.0285197.g003.jpg |
0.404759 | fd3f1e2fbb134df5bed75089bcd61792 | Effect of tirzepatide vs placebo on body weight. | PMC10159347 | pone.0285197.g004.jpg |
0.377971 | a88871dd82d14e3692b357c4d16fe941 | Effect of tirzepatide vs GLP-1 RAs (semaglutide and dulaglutide) on body weight. | PMC10159347 | pone.0285197.g005.jpg |
0.423128 | 97e21b1290d34e0c93c2a60d4a74781f | Effect of tirzepatide vs insulin (insulin degludec and insulin glargine) on body weight. | PMC10159347 | pone.0285197.g006.jpg |
0.403616 | 79daf0b8c40d4789be10b60197703e48 | Scaffolding strategy to assemble multi-enzymatic systems.a Schematic representation of the TRAP-based scaffold composed by TRAP1 (in purple) and TRAP3 (in blue) and their corresponding cognate recognition peptides (MEEVV for TRAP1 and MRRVW for TRAP3) fused to FDH dimer (in red, PDB ID: “5DNA [10.2210/pdb5DNA/pdb]”) and AlaDH hexamer (in green, PDB ID: “1PJB [10.2210/pdb1PJB/pdb]”). b Assembly architecture, in which first AlaDH3 hexamer nucleates 6 TRAP1-3 units and the complex is then loaded with three FDH1 dimers, resulting in a 6:3:1 TRAP1-3:FDH1:AlaDH3 stoichiometry in the final assembly (i.e. a 1:1:1 stoichiometry of monomers). c Hydrodynamic radius (Rh) of the different systems measured by Fluidity One W. Rh of free scaffold (TRAP1-3), tagged enzymes (FDH1 and AlaDH3), incomplete assemblies with only one enzyme bound (FDH1@TRAP and AlaDH3@TRAP), and complete assembly with the two enzymes bound (FDH1/AlaDH3@TRAP). The data are presented as the mean of two replicate experiments (n = 2). Source data are provided as Source Data file. | PMC10160029 | 41467_2023_38304_Fig1_HTML.jpg |
0.418552 | 8a7d5e17e63f42c0a8c44a43016a01b3 | Activity of scaffolded enzyme systems on TRAP assemblies.Relative activity of free enzymes (FDH1 and AlaDH3) and scaffolded enzyme systems (FDH1@TRAP, AlaDH3@TRAP, and FDH1/AlaDH3@TRAP). 100% of AlaDH and FDH activities correspond to 22.1 U·mg−1 and 0.83 U·mg−1, respectively. The data are presented as the mean of two replicate experiments (n = 2). Source data are provided as Source Data file. | PMC10160029 | 41467_2023_38304_Fig2_HTML.jpg |
0.446732 | 4cc4443c260844aa85e703fb323720fc | L-Alanine synthesis activity of the scaffolded enzymes in batch-mode.a Scheme of the catalytic cycle that was tested by the HPLC. b L-Alanine yield at 1:1 molar ratio of FDH1:AlaDH3 monomers for the free enzyme system (FDH1/AlaDH3, empty circles) and the scaffolded enzyme system (FDH1/AlaDH3@TRAP, full circles). c Structure of the TRAP1-3 scaffold showing the surface electrostatic potential. Peptides 1 and 3 are shown in orange and green sticks, respectively and the distance between the two recognition sites is shown. NADH co-factor docked on the TRAP scaffold is shown in light blue sticks representation. d Interpolation line for FDH1/AlaDH3 free system with the transient time highlighted with an arrow. Reaction mixture: 100 mM formate, 75 mM pyruvate, 500 mM ammonium chloride and 0.5 mM NADH. The data are presented as the mean of two replicate experiments (n = 2), and error bars represent standard deviations. Source data are provided as Source Data file. | PMC10160029 | 41467_2023_38304_Fig3_HTML.jpg |
0.483583 | 8eeb0587c1b24c3ea8e91bc232b613d7 | Side reaction competitive catalytic assay.a Schematic representation of the competitive catalytic assay reaction. b Competitive catalytic assay results reported as the consumption of NADH cofactor measured at 340 nm and the formation of H2O2 by measuring the production of resorufin at 560 nm. Both reactions using separately scaffolded enzymes (FDH1@TRAP/AlaDH3@TRAP, empty bars) or scaffolded enzymes in the same scaffold (FDH1/AlaDH3@TRAP, filled bars) were analyzed at both wavelengths to observe changes in the NADH consumption and H2O2 formation. Reaction mixture: 100 mM formate, 75 mM pyruvate, 500 mM ammonium chloride, 0.5 mM NADH, 0.15 mM FAD+, 0.1 mg/mL HRP, and 0.05 mM Amplex Red (AR). The data are presented as the mean of two replicate experiments (n = 2). Source data are provided as Source Data file. | PMC10160029 | 41467_2023_38304_Fig4_HTML.jpg |
0.432786 | ce05ac2abba24e3f9a3bf0025ef29421 | Isotopic enrichment assay coupled to competition assay for the synthesis of L-Alanine-2-d.a Scheme of the catalytic cycle that was tested by the HPLC-MS. b Isotopic abundance of deuterated L-Alanine-2-d (M/z = 324) for the free enzyme system (FDH1/AlaDH3, empty circles) and the scaffolded enzyme system (FDH1/AlaDH3@TRAP, filled orange circles). Reaction mixture: 75 mM deuterated formate, 25 mM formate, 75 mM pyruvate, 500 mM ammonium chloride, 0.5 mM NADH and 0.15 mM FAD+. Alanine standard is shown in filled black circles. Source data are provided as Source Data file. | PMC10160029 | 41467_2023_38304_Fig5_HTML.jpg |
0.378272 | 6241fed5bc694a81aba38792757f7f6b | Confocal fluorescence microscopy images (20X magnification) of co-immobilized FDH1/AlaDH3@TRAP on tri-functional carrier.AlaDH3 and FDH1 were labeled with Alexa Fluor-488 (AF488) and Alexa-Fluor 647 (AF647). a Spatial distribution of AlaDH3 (green channel), b FDH1 (red channel) and c overlay of the two fluorophores. The inlet shows micrographs at lower magnification. d Radial profile and e relative infiltration distance of labeled AlaDH3 (green line and bar) and FDH1 (red line and bar). Relative infiltration distance is defined as the fraction of the radius where the fluorescence intensity was higher than 50% of the maximum intensity. The data are presented as the mean of ten replicate experiments (n = 10), and error bars represent standard deviations. f Co-localization map created with Colormap Image J plugin. The scale refers to the co-localization degree of the two labeled enzymes. Blue pixels (value = −1) mean the absence of co-localization. Red pixels (value = 1) mean a high degree of co-localization. The regions framed with the dashed red square represent those pixels with co-localization values > 0.1 where the spatial colocalization of the two fluorophores is statistically significant. Source data are provided as Source Data file. | PMC10160029 | 41467_2023_38304_Fig6_HTML.jpg |
0.459987 | c07d29cd73e54df7b4704da8f9cd8c71 | Operational performance and reusability of the scaffolded enzyme systems immobilized on porous carriers.a L-Alanine yield % comparing different multi-enzyme systems in solution and immobilized after 24 h. b L-Alanine yield % in a reusability test for free (FDH1/AlaDH3) (empty bars) and scaffolded (FDH1/AlaDH3@TRAP) (orange bars) enzyme systems. Reaction mixture: 100 mM formate, 75 mM pyruvate, 500 mM ammonium chloride and 0.5 mM NADH. The data are presented as the mean of two replicate experiments (n = 2). Source data are provided as Source Data file. | PMC10160029 | 41467_2023_38304_Fig7_HTML.jpg |
0.443269 | cc63f9b7079e4dd9a3366bcd2490aa2d | Benzylamine biosynthesis using a three-enzyme organized multi-enzymatic system.a Scheme of the parallel reactions to produce benzylamine. b Relative activity of ωTA2 in the free and scaffolded form (FDH1/ωTA2/AlaDH3@TRAP). 100% of ωTA activity corresponds to 5.58 U·mg−1. c Benzylamine chromatographic yield % at an enzyme monomer ratio of 1:1:1 for in free (FDH1/ωTA2/AlaDH3) and scaffolded system (FDH1/ωTA2/AlaDH3@TRAP). Reaction mixture: 10 mM benzaldehyde, 50 mM pyruvate, 500 mM ammonium formate, 0.1 mM PLP and 0.5 mM NADH. The data are presented as the mean of two replicate experiments (n = 2). Source data are provided as Source Data file. | PMC10160029 | 41467_2023_38304_Fig8_HTML.jpg |
0.43042 | f05ce07f6e75411595c07f26dfd81871 | a Stick balancing on a linear track. The stick is pinned to the cart, which is constrained to move along the rail. Subjects were asked to sit on a chair so that their shoulders were parallel to the rail, and balance the stick in the ML direction with their dominant hand using the handle of the cart. b Two degree of freedom mechanical model of the stick balancing task, where the generalized coordinates are \documentclass[12pt]{minimal}
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\begin{document}$$\varphi $$\end{document}φ and x. The stick exerts planar motion in the \documentclass[12pt]{minimal}
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\begin{document}$$(x_1,y_1)$$\end{document}(x1,y1) plane. The mass and length of the stick are m and \documentclass[12pt]{minimal}
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\begin{document}$$\ell $$\end{document}ℓ, respectively. The mass and height of the truncated cone for modeling the human forearm are \documentclass[12pt]{minimal}
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\begin{document}$$m_{\textrm{f}}$$\end{document}mf and \documentclass[12pt]{minimal}
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\begin{document}$$\ell _{\textrm{f}}$$\end{document}ℓf, the radius of the base and top circles are \documentclass[12pt]{minimal}
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\begin{document}$$r_{\textrm{f}}$$\end{document}rf and \documentclass[12pt]{minimal}
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\begin{document}$$R_{\textrm{f}}$$\end{document}Rf, respectively. The mass of the hand and of the cart are \documentclass[12pt]{minimal}
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\begin{document}$$m_{\textrm{h}}$$\end{document}mh and \documentclass[12pt]{minimal}
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\begin{document}$$m_{\textrm{c}}$$\end{document}mc | PMC10160210 | 422_2023_957_Fig1_HTML.jpg |
0.416201 | 4afebf3da1864a1db5b690b13bf09aea | Linear stability diagrams for a stick of length \documentclass[12pt]{minimal}
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\begin{document}$$\ell =90$$\end{document}ℓ=90 cm controlled by DSF and by PF for feedback delay \documentclass[12pt]{minimal}
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\begin{document}$$\tau =230$$\end{document}τ=230 ms. The dashed black curves show the stability boundaries for PF while \documentclass[12pt]{minimal}
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\begin{document}$$P_{\textrm{c}}=D_{\textrm{c}}=0$$\end{document}Pc=Dc=0, the stable domain in this case is the quarter plane defined by \documentclass[12pt]{minimal}
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\begin{document}$$P_{\textrm{s}}\ge g(m+m_{\textrm{e}})$$\end{document}Ps≥g(m+me) and \documentclass[12pt]{minimal}
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\begin{document}$$D_{\textrm{s}}\ge 0$$\end{document}Ds≥0. The solid black curves show the stability boundaries for DSF while \documentclass[12pt]{minimal}
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\begin{document}$$P_{\textrm{c}}=D_{\textrm{c}}=0$$\end{document}Pc=Dc=0 and the stable region is shown by gray shading. The blue and the red curves show the D-curves for PF and DSF respectively, while \documentclass[12pt]{minimal}
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\begin{document}$$P_{\textrm{c}}$$\end{document}Pc and \documentclass[12pt]{minimal}
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\begin{document}$$D_{\textrm{c}}$$\end{document}Dc are set according to the label above each panel. Reddish and blueish shaded areas indicate the corresponding stable domains | PMC10160210 | 422_2023_957_Fig2_HTML.jpg |
0.460584 | 455dc7770eac4623be0db765f353927f | a Time histories, phase portraits and PSDs of \documentclass[12pt]{minimal}
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\begin{document}$$\varphi $$\end{document}φ and x for a representative trial by S21 (OD subject). b Time histories, phase portraits and PSDs of the solution provided by the DSF model with parameters identified for S21. Parameters: \documentclass[12pt]{minimal}
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\begin{document}$$P_{\textrm{s}}=22, D_{\textrm{s}}=6.3, P_{\textrm{c}}=0.5, D_{\textrm{c}}=1, \varPi _{{\dot{\varphi }}}=0.05^{\circ }$$\end{document}Ps=22,Ds=6.3,Pc=0.5,Dc=1,Πφ˙=0.05∘/s, \documentclass[12pt]{minimal}
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\begin{document}$$\varPi _{\varphi }=0.05^{\circ }$$\end{document}Πφ=0.05∘, \documentclass[12pt]{minimal}
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\begin{document}$$\tau =200$$\end{document}τ=200 ms | PMC10160210 | 422_2023_957_Fig3_HTML.jpg |
0.438065 | 66911fdcc7af41ee94e1c50fb535a0d3 | a Time histories, phase portraits and PSDs of \documentclass[12pt]{minimal}
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\begin{document}$$\varphi $$\end{document}φ and x for a representative trial by S6 (MD subject). b Time histories, phase portraits and PSDs of the solution provided by the DSF model with parameters identified for S6. Parameters: \documentclass[12pt]{minimal}
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\begin{document}$$P_{\textrm{s}}=25.2, D_{\textrm{s}}=9.6, P_{\textrm{c}}=0.5, D_{\textrm{c}}=1, \varPi _{{\dot{\varphi }}}=0.1^{\circ }$$\end{document}Ps=25.2,Ds=9.6,Pc=0.5,Dc=1,Πφ˙=0.1∘/s, \documentclass[12pt]{minimal}
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\begin{document}$$\varPi _{\varphi }=0^{\circ }$$\end{document}Πφ=0∘, \documentclass[12pt]{minimal}
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\begin{document}$$\tau =170$$\end{document}τ=170 ms | PMC10160210 | 422_2023_957_Fig4_HTML.jpg |
0.46547 | 55eebd7357434e32a4252026b7ece59e | Stabilometry parameters determined from the measured time signals of \documentclass[12pt]{minimal}
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\begin{document}$$\varphi $$\end{document}φ and x as a function of subject number. Symbol ‘+’ denotes values for many-day (MD) subjects, while ‘\documentclass[12pt]{minimal}
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\begin{document}$$*$$\end{document}∗’ denotes values for one-day (OD) subjects. Black markers show stabilometry values for measurements and red markers show stabilometry values obtained from simulations with the control parameters identified for each subject individually. Green check marks show significant difference (\documentclass[12pt]{minimal}
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\begin{document}$$p<0.05$$\end{document}p<0.05) in the stabilometry parameters between MD (S1–S6) and OD balancers (S7–S31) while red cross depicts no significant difference | PMC10160210 | 422_2023_957_Fig5_HTML.jpg |
0.421815 | 2b4c0074e04f44a29eea137dc661c2d8 | Top: distribution of the identified \documentclass[12pt]{minimal}
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\begin{document}$$\tau $$\end{document}τ values based on the minimum of the cost function for a many-day (MD) and for b one-day (OD) subjects for the DSF model. Bottom: boxplot for the cost function values as a function of the applied time delays for c MD and for d OD subjects. Red central mark: median; blue box: interquartile range (IQR); black dashed whiskers: min–max values not considered outliers; red \documentclass[12pt]{minimal}
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\begin{document}$$+$$\end{document}+ marks: outliers | PMC10160210 | 422_2023_957_Fig6_HTML.jpg |
0.410285 | 3db194f890814ea4b6df830420f593ff | Top: distribution of the identified \documentclass[12pt]{minimal}
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\begin{document}$$\tau $$\end{document}τ values based on the minimum of the cost function for a many-day (MD) and for b one-day (OD) subjects for the PF model. Bottom: boxplot for the cost function values as a function of the applied time delays for c MD and for d OD subjects. Boxplot notation is the same as in Fig. 6 | PMC10160210 | 422_2023_957_Fig7_HTML.jpg |
0.41322 | 557b624d2e5d476ab8e9d9359d26cd12 | Validation of the parameter identification method using simulation with the identified OD parameters of the DSF model. Top: distribution of the identified \documentclass[12pt]{minimal}
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\begin{document}$$\tau $$\end{document}τ values based on the minimum of the cost function for a PF and b DSF model. Bottom: boxplot for the cost function values as a function of the applied time delays for c PF and for d DSF model. Boxplot notation is the same as in Fig. 6 | PMC10160210 | 422_2023_957_Fig8_HTML.jpg |
0.475447 | 6297b52fec90402d864bf79fbb0fb4c6 | Left panels: linear stability diagrams of a MD and c OD subjects, symbol ‘+’ denotes the estimated \documentclass[12pt]{minimal}
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\begin{document}$$P_{\textrm{s}}$$\end{document}Ps and \documentclass[12pt]{minimal}
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\begin{document}$$D_{\textrm{s}}$$\end{document}Ds values for MD, while ‘\documentclass[12pt]{minimal}
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\begin{document}$$*$$\end{document}∗’ denotes the estimated \documentclass[12pt]{minimal}
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\begin{document}$$P_{\textrm{s}}$$\end{document}Ps and \documentclass[12pt]{minimal}
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\begin{document}$$D_{\textrm{s}}$$\end{document}Ds values for OD subjects. Grey shading indicates stable regions and contour curves indicate different exponential decay rates \documentclass[12pt]{minimal}
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\begin{document}$$\gamma $$\end{document}γ. Right panels: the corresponding time histories for b MD and d OD subjects (without dead zone applied in the model) | PMC10160210 | 422_2023_957_Fig9_HTML.jpg |
0.530477 | 1172a883ea2c496ab816c852d8da7c96 | Kaplan-Meier analysis of OS and PFS for BLNLR, ΔNLR%, BMI, number of metastatic sites. (A) OS curve for BLNLR. (B) OS curve for ΔNLR%. (C) OS curve for BMI. (D) OS curve for number of metastatic sites. (E) PFS curve for BLNLR. (F) PFS curve for ΔNLR%. (G) PFS curve for BMI. (H) PFS curve for number of metastatic sites. BLNLR, neutrophil-to-lymphocyte ratio before the first cycle of PD-1 inhibitor; ΔNLR%, relative NLR change (calculated as % change) before the third cycle of PD-1 inhibitor; BMI, body mass index; OS, overall survival; PFS, progression-free survival. | PMC10160371 | fonc-13-1118301-g001.jpg |
0.44214 | 50364e01aec84543b8338be80e3b7e91 | Kaplan-Meier analysis of OS and PFS for the combination of BLNLR and ΔNLR%. (A) OS curve. (B) PFS curve. BLNLR, neutrophil-to-lymphocyte ratio before the first cycle of PD-1 inhibitor; ΔNLR%, relative NLR change (calculated as % change) before the third cycle of PD-1 inhibitor; BMI, body mass index; OS, overall survival; PFS, progression-free survival. | PMC10160371 | fonc-13-1118301-g002.jpg |
0.463179 | 583bf30817d04b9791ec9c050dfd59f6 | Pathway and resource use associated with risk-stratification in a breast cancer screening programme
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0.447046 | ce5e44d37149431099d3245dfc42942c | Pathway and resource use for obtaining breast density images (sub-model A). | PMC10161319 | 10.1177_23814683231171363-fig2.jpg |
0.482993 | 01349d3c7e724955a2920c4452ce1ce4 | Pathway and resource use for obtaining genetic data (sub-model B). | PMC10161319 | 10.1177_23814683231171363-fig3.jpg |
0.553128 | 36b36de712a148c7b49cc86dbb1055d6 | Cost of genetic testing (SNP analysis) by batch size. | PMC10161319 | 10.1177_23814683231171363-fig4.jpg |
0.461713 | 22fbe6a0e8ba4648b4093791757e9203 | Legend? | PMC10162604 | APJCP-24-471-g001.jpg |
0.447954 | 851dc90e001240aa9a185150a5b306c5 | Box Plot of Different Delays | PMC10162604 | APJCP-24-471-g002.jpg |
0.506571 | 73d86842dbf74aaa8802517e72452b3b | Blaschkoid lesions on the lower limb | PMC10162736 | IJD-68-123e-g001.jpg |
0.456946 | 7c1048b57e694a1dbe5c9d379250bc11 | Lesions in Blaschkoid pattern on the back | PMC10162736 | IJD-68-123e-g002.jpg |
0.466914 | 58fab683d9f7434da17389089a3e93b4 | Lesions on the front of the chest | PMC10162736 | IJD-68-123e-g003.jpg |
0.495875 | 32b70a7cb2e8445fac9d2c5609a453b8 | 10× view histopathology showing psoriasiform dermatitis | PMC10162736 | IJD-68-123e-g004.jpg |
0.438203 | ff1394349be3420eb5c418a193f4acac | 40× view histopathology showing hyperkeratosis, parakeratosis, and thinned granular layer | PMC10162736 | IJD-68-123e-g005.jpg |
0.460663 | 162de9d192844fa19810f1705174f371 | Components of the delivery strategies for RTS, S/AS01E vaccination in areas with seasonal malaria. EPI, Essential Programme on Immunisation. | PMC10163455 | bmjgh-2023-011838f01.jpg |
0.41105 | 354acdaa04704789857f8493ea7c76ac | Potential strategies for the delivery of RTS, S/AS01E alongside SMC. EPI, Essential Programme on Immunisation; MVCs, mass vaccination campaigns; NMCP, National Malaria Control Programme; SMC, seasonal malaria chemoprevention. | PMC10163455 | bmjgh-2023-011838f02.jpg |
0.41051 | eda8f8b51e1d49fc98f8ae2e0268d73d | The benefits and challenges are labelled as to whether within the strategy, they relate to the vaccination schedule, or the delivery system(s) used. EPI, Essential Programme on Immunisation; HWs, health workers; MVCs, mass vaccination campaigns; SMC, seasonal malaria chemoprevention. | PMC10163455 | bmjgh-2023-011838f03.jpg |
0.565487 | 037c540314424ee58a98631523ba916a | Holistic needs assessment: the concerns checklist. | PMC10163480 | bmjopen-2022-066829f01.jpg |
0.517028 | 7e9cce9cd41d49559ab0d006c5dba94f | Flow of participants through the trial. | PMC10163480 | bmjopen-2022-066829f02.jpg |
0.43173 | bea16a0600a249e085fd7ca3c27d6719 | Barchart: Mean scores for Lorig Self-Efficacy scale by group, with 95% CIs. | PMC10163480 | bmjopen-2022-066829f03.jpg |
0.422856 | f7a9fe8742c04080b66c83a5c78fb62f | Opioid Prescribing by Race/Ethnicity and Guideline-Procedure Group. Mean percent differences in prescribed total morphine milligram equivalents (MME) versus non-Hispanic white group were derived from statistical models, with adjustment and propensity-score weighting for warranted covariates (see Methods section). Error bars represent 95% confidence intervals. Above or below each bar is the calculated, absolute mean difference in total MME and, in parentheses, the mean difference in 5-mg oxycodone equivalent pills, for each racial and ethnic minority group relative to the NHW group based on unadjusted values for NHW patients. *Indicates statistically significant difference, at alpha of 0.05, in bold text. MIS, minimally invasive surgery; NHA, non-Hispanic Asian; NHB, non-Hispanic Black; NHO, non-Hispanic Other; SLNB, sentinel lymph node biopsy; TKA, total knee arthroplasty | PMC10163682 | 13690_2023_1095_Fig1_HTML.jpg |
0.453829 | da8a16b8ac5b4dac80ce52d98d2c0a71 | Flowchart of the Search Phases to Select Studies for Systematic Review Based on the PRISMA Statement | PMC10163913 | IJPS-18-83-g001.jpg |
0.423535 | 3ff9b1cf23b74b5ebee9482a81c20aee | Proliferation and differentiation of large yellow croaker PSCs and PADSCs.a Diagrams showing that epaxial muscles and coelom walls of large yellow croaker were used to isolate the primary culture of PSCs and PADSCs respectively. Scale bars: 80 µm. b Primary cultures at different time points and passage 3 of PSCs and PADSCs. Scale bars: 80 µm; c The growth curves of PSCs and PADSCs at passage 3 were analyzed by CCK-8 method with three replicates. d Representative images of immunofluorescence staining of PSCs at passage 3. Green: Pax7 or MyoD1; Blue: Hoechst 33342 for nuclear staining. Scale bars: 80 µm. e Average percentages of Pax7- and MyoD1-positive cells derived from image d with five replicates. Box indicates IQR; whisker indicates min or max; plus shows mean. f Representative images of bright-field and fluorescence staining of PSCs during myogenic differentiation at day 0, 3, 6. Green: Desmin; Blue: Hoechst 33342; Scale bars: 80 µm. g Myotube fusion index counted from image i with five replicates. Box: IQR; Whiskers: min or max; Plus: mean. h Image of immunofluorescence staining of PADSCs at passage 3. Green: HoxC9; Blue: Hoechst 33342. Scale bars: 80 µm. i Average percentage of HoxC9-positive cells counted from image f with 5 replicates. Box: IQR; Whisker: min or max; Plus: mean. j Representative images of bright-field and oil red O staining of PADSCs during adipogenic differentiation at day 0, 1, 6. Lipid droplets in red were stained by oil red O and nuclei in blue were stained by hematoxylin. Scale bars: 40 µm. | PMC10164169 | 41538_2023_194_Fig1_HTML.jpg |
0.382771 | dba704c56d8346ff857f0e23509623b0 | Improving the myogenic differentiation efficiency by transcriptomic analysis.a Heatmap showing the z value of all differentially expressed genes during myogenic differentiation between day 0, day 3 and day 6. Genes (rows) and sample (columns) were clustered using average linkage clustering with Euclidean distances. b Volcano plot showing differentially expressed genes between day 0 and day 3. Significantly differentially expressed myogenesis genes were highlighted. c Top 10 enrichment GO analysis for up-regulation (red bar) and downregulated (blue bar) DEGs at day 3, compared to day 0. The number indicated the proportion of the significantly up/downregulated genes in total genes per gene ontology. d–i, Heatmaps showing the expression patterns of genes corresponding to myogenesis (d), cell cycle (e), notch signal pathways (f), TGF-beta signal pathways (g), myofibroblastic (h), extracellular matrix (i), from day 0 to day 6. j Representative bright-field and immunofluorescence images of PSCs at day 6 in different differentiation media. In first two days, the cells were cultured with F12 medium containing 8% HS, 1×PS and with or without Repsox (R, 5 μM) and LY411575 (L, 10 nM). After 2 days. The culture was added with same volume DMEM medium containing 8% FBS, 200 nM dexamethasone, 1×PS. Scale bars: 80 µm. k Myotube fusion index counted from images j with three replicates. Statistical analysis was performed on relevant data using Student’s two-tailed t-test. Error bars indicated s.d. **P < 0.005, ***P < 0.0005. | PMC10164169 | 41538_2023_194_Fig2_HTML.jpg |
0.409942 | 139f6094967e426a9b48bf9928255dde | Effects of supporting materials of 3D-scaffold on fish cell adhesion and growth.a Average cell viabilities in different supporting materials including porcine gelatin (PG), fish gelatin (FG), Hyaluronic acid (HA), silk fibroin (SF), and chitosan. Statistical analysis was performed on relevant data using Student’s two-tailed t-test. Error bars for three replicates indicated s.d. NS: not significant; *P < 0.05. b, c Gel point (b) and viscosity (c) of supporting materials with different ratios of gelatin basis (5/10%) and 1% sodium alginate (SA). The square and triangle symbols in b represented G’ and G” respectively. d Calcein-AM fluorescence images of PSCs treated with different concentrations of CaCl2 for different times. The non-adherent PSCs were spherical, while the adherent PSCs became spindle-shaped and gradually underwent proliferation. Scale bar, 50 μm. e, f Elastic modulus of scaffolds (e) and cell adhesion rates of PSCs (f) treated with different concentrations of CaCl2 for different times. The experiments were repeated for three times and statistical analysis was performed on relevant data using Student’s two-tailed t-test. Error bars indicated s.d. **P < 0.005, ****P < 0.0001. g Average number of PSCs measured with CCK-8 kit at day 5 of 3D culture with three replicates. Error bars indicated s.d. **P < 0.005, ***P < 0.0005, ****P < 0.0001. h Average myotube fusion index in different 3D Culture Conditions as indicated. R: Repsox; L: LY411575. Statistical analysis was performed on relevant data using Student’s two-tailed t-test. Error bars for three replicates indicated s.d. **P < 0.005, ***P < 0.0005. | PMC10164169 | 41538_2023_194_Fig3_HTML.jpg |
0.403572 | 23fbfdba1d484bffaae4b59e3e9833af | Muscle tissue formation under guidance of biomimetic model of scaffold.a Schematic diagram of construction of biomimetic 3D-printed model based on native large yellow croaker muscle tissue. b Micro-CT images of native fish epaxial muscle. Blue: Intermuscular filler tissues; Orange: Muscle tissues; Muscle scaffold model was designed from simplified native muscle texture. Scale bar: 1 mm. c Calcein-AM fluorescence images of PSCs in scaffolds at day 3 and 10 days of proliferation. Scale bar, 100 μm. d Representative fluorescence image of myobubes in 3D culture at days 7 of differentiation. The PSCs in scaffolds were cultured in proliferation medium for 10 days, and then transferred to differentiation medium for 7 days. Green: Desmin; Blue: DAPI. Scale bar, 100 μm. e Growth curve of PSCs in optimized gelatin-based scaffold. Error bars for three replicates indicate s.d. | PMC10164169 | 41538_2023_194_Fig4_HTML.jpg |
0.423206 | 28a87864d4bb48dfae174194a518ebbe | Characterization of tissue-like cultured fish fillets.a Representative images of cultured and native tissue fillets of large yellow croaker. Scale bar, 5 mm. b Average numbers of muscle cells and adipocytes in cultured fish fillets and native fish fillets with a size about 0.96 cm3. Error bars for three replicates indicated s.d.. NS: not significant. *P < 0.05. c Muscle and fat ratios in cell cultured fish fillets and native fish fillets. Error bars for three replicates indicated s.d. NS, not significant. *P < 0.05. d Representative images of muscle fibers of native fish fillets and cultured fish fillets. Red: hematoxylin-eosin (HE) staining; SEM: scanning electron microscopy; Scale bar, 100 μm. e Texture properties of empty scaffold, cultured fish fillet and native fish fillet. f Water distribution of transverse relaxation time (T2) spectra. “a.u.” denoted arbitrary unit. | PMC10164169 | 41538_2023_194_Fig5_HTML.jpg |
0.526329 | e00b4dfee44140188b208cb8345d2fcd | INCISIVE common data model backbone | PMC10164664 | 41747_2023_336_Fig1_HTML.jpg |
0.397956 | ae1675c7c43c4dc8bee4b6ce556dcd8e | The Extract-Transform-Load (ETL) process in INCISIVE | PMC10164664 | 41747_2023_336_Fig2_HTML.jpg |
0.402135 | 5badbe74640d468e9ef3c50d264b7ae3 | Diagnostic workup in AIHA. A, additional criteria for mixed AIHA (DAT strongly positive for both IgG and C3d, cold agglutinin titer ≥64, indirect antiglobulin test positive for IgG at 37°C); ARC, absolute reticulocyte count; BM, bone marrow; CAD, cold agglutinin disease; cAIHA, cold-antibody autoimmune hemolytic anemia; CAS, cold agglutinin syndrome; DAT, direct antiglobulin test; LDH, lactate dehydrogenase; SPEP, serum protein electrophoresis; wAIHA, warm-antibody autoimmune hemolytic anemia. | PMC10165002 | fimmu-14-1180509-g001.jpg |
0.457284 | 8beeb91edd5a46ac952a2cac038ba140 | Severity of anemia in CAD. Hemoglobin levels correlate negatively with parameters of hemolysis, but do not correlate with IgM levels. LDH, lactate dehydrogense; LLN, lower limit of normal. Based on data from Berentsen et al. (61). Figure first published in Front Immunol 2020 by Berentsen (71), reused under a Creative Commons CC-BY license 4.0 (https://creativecommons.org/licenses/by/4.0/). © S. Berentsen 2020. | PMC10165002 | fimmu-14-1180509-g002.jpg |
0.454084 | 00f5336add7c4580a0562fe99ab7c643 | Suggested therapeutic algorithm in warm-antibody AIHA. ESA may be used as a supplement at any stage as well as in the last line. CyA, cyclosporine A; ESA, erythropoiesis-stimulating agent; Pred, prednisolone or prednisone. | PMC10165002 | fimmu-14-1180509-g003.jpg |
0.430019 | 4c4259b95e2646b9a4eccd15c98c47bd | Suggested therapeutic algorithm in cold agglutinin disease. B, bendamustine; R, rituximab; W&W, watch and wait. | PMC10165002 | fimmu-14-1180509-g004.jpg |
0.462491 | 49d182e98c98489480fd8c3a93968fcc | Variable network based on GLASSO model (Lambda = 0.1). | PMC10165092 | fpsyg-14-1129692-g001.jpg |
0.480039 | 7b0991f6f1ee42b1aeaeb880f22e403c | Estimation results of a higher-order factor model of the influence mechanism of teachers’ emotional intelligence. | PMC10165092 | fpsyg-14-1129692-g002.jpg |
0.515902 | bf51c4ac60ae4cffb20c333590298fcd | Structural equation model estimation results of AEE affecting life satisfaction. | PMC10165092 | fpsyg-14-1129692-g003.jpg |
0.506875 | c5280a9f4afa4c93b4cc4cdac557a424 | Structural equation model estimation results of UE affecting life satisfaction. | PMC10165092 | fpsyg-14-1129692-g004.jpg |
0.53016 | e46f725365424560ab513fb0fa10aa37 | Structural equation model estimation results of RE affecting life satisfaction. | PMC10165092 | fpsyg-14-1129692-g005.jpg |
0.404655 | 2aa459d2e7fa4fa3ad0bd1fe7ee1b223 | Selection of study participants. | PMC10165120 | fpsyt-14-1152286-g001.jpg |
0.411517 | 158c94ac57b840d58d7393d091dff6f3 | Associations between predictors and initiation of medication use for attention deficit hyperactivity disorder (odds ratios and 95% confidence intervals comparing initiators with non-initiators). | PMC10165120 | fpsyt-14-1152286-g002.jpg |
0.47559 | 35c4c32171934ee68ec211cae062ae4d | (A) Time to discontinuation of attention deficit hyperactivity disorder medication use (N = 20179). (B) Time to discontinuation of use for 5 most common initial attention deficit hyperactivity disorder medication (other medications have very few users). LA, long-acting; SA, short-acting; polytherapy, initiation with two or more drugs at the same time. | PMC10165120 | fpsyt-14-1152286-g003.jpg |
0.425536 | b626d57a97e94387827bd8c27ae9740c | Associations between predictors and discontinuation of attention deficit hyperactivity disorder (ADHD) medication (hazard ratios and 95% confidence intervals comparing those who discontinued with those who continued ADHD during the follow-up. | PMC10165120 | fpsyt-14-1152286-g004.jpg |
0.424786 | 8e723f6945e8450da0d75c245e753dd4 | The operation process of PEB. (a) The 8‐F vascular introducer sheath was put in close touch with tissue in the filling defect according to angiography. (b) Multiangle angiography to determine the relative position of the sheath and the lesion. (c) Endomyocardial biopsy forceps (2.2 mm × 50 cm, 7 F Maxi‐Curved; Argon Medical Devices). (d) Under fluoroscopic guidance, the biopsy device was advanced outside the introducer tip and subsequently gently placed on the mass to obtain the tissue sample. (e) After the procedure, a second pulmonary angiography confirmed the absence of vascular injury. (f) Right pulmonary artery mass tissue obtained by biopsy forceps and the final histological findings was TE by choriocarcinoma. PEB, percutaneous endovascular biopsy; TE, tumoral embolism. | PMC10166081 | PUL2-13-e12234-g001.jpg |
0.442451 | 7da4d69ded1445be9ba5e24be47c96aa | The difference between 8‐F MPA catheter and 8‐F vascular introducer sheath. (a) The biopsy forceps can just pass through the 8‐F MPA catheter (outer diameter of 2.7 mm; inner diameter of 2.2 mm; Cordis). And the biopsy forceps needed to be sent outside the tip of the catheter for angiography to determine the location of the biopsy forceps (red arrow). (b) The 8‐F vascular introducer sheath (inner diameter of 2.87 mm, Super Arrow‐Flex; Arrow) with a large space between the biopsy forceps and the sheath. Angiography can be directly performed to confirm that the tip of the introducers is adjacent to the mass without pulling back the introducer sheath (red arrow). MPA, main pulmonary artery. | PMC10166081 | PUL2-13-e12234-g002.jpg |
0.456341 | 37d8f15cb91947da99bd50447e63115a | Meta-analysis flow-chart diagram according to the PRISMA guideline. | PMC10166833 | fmed-10-1171294-g001.jpg |
0.482627 | 871dfb2fe0c344ffb3b5867804bf51f5 | Methodological quality assessment of the included studies (Cochrane risk-of-bias tool 1.0). | PMC10166833 | fmed-10-1171294-g002.jpg |
0.494098 | ae44790b8aad4cec8f073a746df17e02 | The forest plot depicts the mortality by comparing the melatonin group versus control group. | PMC10166833 | fmed-10-1171294-g003.jpg |
0.417878 | f818261117a94e1db498745c999101d1 | Forest plots demonstrate the secondary outcomes comparing the melatonin group versus control group in (A) recovery rate of symptoms, (B) changes of C-reactive protein (CRP), (C) changes of Erythrocyte sedimentation rate (ESR), (D) changes of Neutrophil-to-lymphocyte ratio (NLR). | PMC10166833 | fmed-10-1171294-g004.jpg |
0.447411 | 79cbb100eb184c4eb139471f863f7886 | Trial sequential analysis of mortality rate. A diversity adjusted information size of 10,277 patients was calculated using 5% of type 1 error (2-sided), a power of 80%, an anticipated relative risk of 20.0%. | PMC10166833 | fmed-10-1171294-g005.jpg |
0.418165 | acf5135ce24c4d299892efaa3ba86924 | Trial sequential analysis of recovery rate of symptoms. A diversity adjusted information size of 2,154 patients was calculated using 5% of type 1 error (2-sided), a power of 80%, an anticipated relative risk of 20.0%. | PMC10166833 | fmed-10-1171294-g006.jpg |
0.473543 | 28611960057840f39f476dbf85d2c18d | Schematic summarizing the multiple avenues of research involving EVs in the retina including (A) examining the contribution different subpopulation of EVs (microvesicles and exosomes) in retinal pathophysiology, (B) developing EV based biomarker for ocular diseases from different biofluids, and (C) targeting retinal diseases with EV-mediated therapies. Figure was prepared using bioRender®. | PMC10166895 | fcell-11-1059141-g001.jpg |
0.456393 | 36fc95e0049c49f48a7874a04d37ce86 | Schematic showing the complex interplay of EVs in the retina with several confounding factors including potential systemic contribution of EVs that need to be further articulated to precisely understand the role of EVs in retinal (patho)physiology, develop rational biomarkers, and target retinal diseases with EV-mediated therapies. Potential EV-mediated autocrine paracrine and signaling between different retinal cell types is illustrated on the left and the possibility of retinal EVs in systemic circulation or EVs from systemic circulation within the retina is indicated on the right. Figure was prepared using bioRender®. | PMC10166895 | fcell-11-1059141-g002.jpg |
0.415815 | b7e58cc4d521450aba1961b8aa5f59c6 | Top-down synthesis methods. (A) Schematic of the laser exfoliation device for 2H-MoS2 flakes in aqueous media (Zhai et al., 2021) (Copyright 2021, American Chemical Society). (B) Schematic of the preparation of MoS2 nanosheets through femtosecond laser exfoliation (Zuo et al., 2021) (Copyright 2021, American Chemical Society). (C) Schematic of the mechanism for laser thinning of MoTe2 (Nagareddy et al., 2018) (Copyright 2018, Wiley-VCH). (D) Schematic of the laser-driven phase patterning process of MoTe2 from 2H to 1T′ (Cho et al., 2015) (Copyright 2015, American Association for the Advancement of Science). | PMC10167011 | fchem-11-1195640-g001.jpg |
0.430099 | 6de6597cbd4a4de8973482c082bbf595 | Bottom-up synthesis methods. (A) Flow diagram of direct laser writing, a method for the laser-directed synthesis of MoS2 on the SiO2/Si wafer (Xu et al., 2021a) (Copyright 2021, Elsevier). (B) Schematic of MoS2 synthesized by femtosecond laser (Xu et al., 2022) (Copyright 2022, American Chemical Society). (C) Schematic of the layer synthesis of MoS2–WS2 heterostructure (Park et al., 2020a) (Copyright 2020, American Chemical Society). (D) Schematic of Au-doped MoS2 (Huo et al., 2021) (Copyright 2021, American Chemical Society). | PMC10167011 | fchem-11-1195640-g002.jpg |
0.444613 | b59eeb5d5ddc4a0e8b1c3fe62b705ba6 | The experimental design of the evaluation test. (A) Experimental set-up. (B) The layout of fNIRS channels. The red dots represented sources, and the blue dots represented detectors. The 15 sources and 15 detectors constitute 30 channels, overlaying six brain regions: LPFC, RPFC, LMC, RMC, LOL, and ROL. (C) Experiment procedure. Each trial consisted of a combination of a 15 s task and a 30 s rest and was repeated five times in each condition. | PMC10167054 | fbioe-11-1176054-g001.jpg |
0.440598 | 81ea04b3d27c430287db513f88605293 | The results of the functional connectivity between 30 channels in different conditions (p < 0.05). (A) Correlation matrix between 30 channels under 20% MVC of the dominant side. (B) Correlation matrix between 30 channels under 80% MVC of the dominant side. (C) The significant difference of functional connectivity of the 80% MVC relative to the 20% MVC between 30 channels under the dominant side. (D) Correlation matrix between 30 channels under 20% MVC of the non-dominant side. (E) Correlation matrix between 30 channels under 80% MVC of the non-dominant side. (F) The significant difference of functional connectivity of the 80% MVC relative to the 20% MVC between 30 channels under the non-dominant side. | PMC10167054 | fbioe-11-1176054-g002.jpg |
0.390955 | d6d721d493ca4a6790fc0158b5f10449 | The results of significant differences in functional connections between brain regions in different conditions. (A,B) The change is represented by the functional connectivity of the 80% MVC relative to the 20% MVC under the dominant side. (C,D) The change is represented by the functional connectivity of the 80% MVC relative to the 20% MVC under the non-dominant side. The red line (p < 0.01) and blue line (0.01 < p < 0.05) indicate significant increase statistically. | PMC10167054 | fbioe-11-1176054-g003.jpg |
0.444608 | f92f4d4e58594d27893177c27979fca8 | The results of significant differences in effective connectivity between brain regions in different conditions. (A,B) The change is represented by the effective connectivity of the dominant side relative to the non-dominant side under 80% MVC. (C,D) The change is represented by the effective connectivity of the dominant side relative to the non-dominant side under 20% MVC. The red line indicates a significant increase statistically (p < 0.05), where * indicates p < 0.05. | PMC10167054 | fbioe-11-1176054-g004.jpg |
0.451262 | a96efd71c3b94c9a809b3b3ecb9174e3 | Significant global and local metric changes of elbow flexion in the contralateral motor cortex. (A) Global metrics results of the clustering coefficient (ΔHbO2). (B) Local metrics results of the node-local efficiency (ΔHbO2), where ** indicates p < 0.01. Abbreviation: DS, dominant side; NDS, non-dominant side. | PMC10167054 | fbioe-11-1176054-g005.jpg |
0.446126 | 1f58c7342adf4ffba132dbb928658f96 |
(A) Change of fApEn of BIC with the change of window N. (B) Change of fApEn of TRI with the change of window N. (C) Change of fApEn of BIC with the change of tolerance r. (D) Change of fApEn of TRI with the change of tolerance r. EMG signals were picked out from four different conditions from a subject. Abbreviation: DS, dominant side; NDS, non-dominant side. | PMC10167054 | fbioe-11-1176054-g006.jpg |
0.445759 | f5a6ad0b730b41168389dcfc27f4af75 |
(A) fApEn values of EMG signals of BIC. (B) fApEn values of EMG signals of TRI. (C) The CCI of EMG signals in different conditions. The significant difference between different conditions was represented by *p < 0.05 and ****p < 0.0001. Abbreviation: DS, dominant side; NDS, non-dominant side. | PMC10167054 | fbioe-11-1176054-g007.jpg |
0.484025 | 03cc63e748b4416cb0a6366c8bb26ea5 |
(A–C) Correlation of HbO2 and fApEn of the dominant side in LPFC (r = 0.6995, p < 0.0001), LMC (r = 0.6268, p < 0.0001) and LOL (r = 0.4815, p = 0.0012). (D–F) Correlation of HbO2 and fApEn of the non-dominant side in RPFC (r = 0.5945, p < 0.0001), RMC (r = 0.5091, p = 0.0006) and ROL (r = 0.5749, p < 0.0001). | PMC10167054 | fbioe-11-1176054-g008.jpg |
0.403484 | e77c0879136448558caa4558274fcaef |
(A,B) Correlation of node-local efficiency and fApEn of the dominant side in LMC (r = 0.3789, p = 0.0133) and the non-dominant side in RMC (r = 0.0371, p = 0.8157). (C,D) Correlation of clustering coefficient and fApEn of the dominant side in LMC (r = 0.2797, p = 0.0728) and the non-dominant side in RMC (r = 0.2045, p = 0.1939). | PMC10167054 | fbioe-11-1176054-g009.jpg |
0.470049 | 999c4d2c8a5b4ad5a37b4cce8c404e62 | Scheme of the pilot cardiac telerehabilitation program. | PMC10167584 | cardio_v7i1e44179_fig1.jpg |
0.437351 | 385a5534ef4d42469467d745de189696 | HumanITcare dashboard: heart rate over the time control panel. | PMC10167584 | cardio_v7i1e44179_fig2.jpg |
0.457802 | d7d09030a9d748fca57932270f4fd780 | The app screen for the patient. PREDIMED: Prevención con Dieta Mediterránea. | PMC10167584 | cardio_v7i1e44179_fig3.jpg |
0.508677 | a93c32a3f45542d2b06219384bc4d67d | Adherence to the Mediterranean diet, emotional state, and quality of life before and after the program in the study population. P<.05 values significantly different between the indicated groups. HADS-A: P=.03; HADS-D: P=.09; PREDIMED: P=.04; EuroQol: P=.006. EuroQoL: European health questionnaire combining quantity and quality of life; HADS-A: Hospital Anxiety and Depression Scale–Anxiety; HADS-D: Hospital Anxiety and Depression Scale–Depression; PREDIMED: Prevención con Dieta Mediterránea—Mediterranean diet using the Mediterranean diet and lifestyle. | PMC10167584 | cardio_v7i1e44179_fig4.jpg |
0.412002 | 85ea9fcfb934486483825dc64c143f3b | PBS-M buffer improves cell viability and does not inhibit reverse transcription.a, The fraction of live C. robusta blood cells recovered after resuspension in CMF-ASW, PBS, or PBS-M buffers. Data is averaged over 3–4 replicates. Shaded regions indicate 95% confidence intervals.b, Capillary electrophoresis traces of amplified cDNA from L1210 cells prepared in CMF-ASW, PBS, or PBS-M buffers. Peaks at 35 bp and 10380 bp are size markers. | PMC10168337 | nihpp-2023.04.26.538465v1-f0001.jpg |
0.462597 | 82553e4f488643bbbdb931534bb78cd6 | PBS-M buffer improves scRNA-seq data quality and recovers missing cell states in C. robusta blood.a, Experimental set-up for testing the effect of cell suspension buffer on scRNA-seq data quality. Blood from five animals was used.b,c, Preparing cells by standard dilution of high-salt buffer (dCMF-ASW) or PBS-M renders differences in: b, the number of single cell barcodes passing the scRNA-seq data filters, and c, the fraction of mapped reads whose barcodes pass the filters. Cells are filtered by the number of transcripts detected and mitochondrial fraction.d, The number of mRNA molecules detected per bin, with cell barcodes binned based on their transcript count. The dashed line shows the median number of transcripts in non-cell barcodes (571 transcripts/barcode in dCMF-ASW and 194 transcripts/barcode in PBS-M). These values quantify the background resulting from free-floating mRNA, which is reduced in PBS-M.e, Histogram of the mitochondrial fraction per cell, an indicator of cell lysis.f, Joint UMAP embedding of cells prepared in dCMF-ASW or PBS-M buffers, with cells colored by sample. Left: dCMF-ASW cells are marked in blue with the rest of the cells in grey. Right: PBS-M cells are marked in pink with the rest of the cells in grey. Cell states strongly depleted in the dCMF-ASW sample are circled in b lack.g, Joint UMAP embedding with cells colored by the log-ratio of the relative local sample density. The coloring represents the amount of local enrichment of cells from PBS-M (pink) or dCMF-ASW (blue) samples. | PMC10168337 | nihpp-2023.04.26.538465v1-f0002.jpg |
0.397858 | c641414054ed40e48593a57dbd4dcf48 | Underlying disease described as the cause of chronic cough in patients with refractory chronic cough (n = 126). Data expressed as number (%) of patients | PMC10169201 | 408_2023_620_Fig1_HTML.jpg |
0.394899 | f65c53c74b9c4723b4ac698bfa35276f | Percentage of patients receiving antibiotic therapies for empirical treatment of chronic cough and number of antibiotic cycles. Numbers in the bars represent the mean (standard deviation) number of cycles received per patient who received a specific antibiotic from each class. Percentages reflect the percentage of patients who had received such an antibiotic at least once to treat chronic cough without evidence of underlying infection. RCC refractory chronic cough, UCC unexplained chronic cough | PMC10169201 | 408_2023_620_Fig2_HTML.jpg |
0.499165 | b1e3f331745548a491001f9592a35784 | Schematic diagram of nested pits for the boundary optimization problem of open pit mines. | PMC10169206 | 41598_2023_34641_Fig10_HTML.jpg |
0.445527 | 1906c86a077b49f79c928424933b2544 | Comparison of the final state adjustment of open pit mines and coal price volatility. | PMC10169206 | 41598_2023_34641_Fig11_HTML.jpg |
0.469952 | e74ce4bd70ab4e8ebbdffb22ee8ad71e | Two-dimensional topology structure of a small inclined coal seam open pit mine. | PMC10169206 | 41598_2023_34641_Fig12_HTML.jpg |
0.519294 | 863204f451054d99a47cfc36236c30b8 | Schematic diagram of the layout of the open pit mine mining and stripping project. | PMC10169206 | 41598_2023_34641_Fig13_HTML.jpg |
0.452422 | ec2211f5f1cc4f95a3c2d442a051066f | Schematic diagram of two-dimensional boundary adjustment under risk conditions. | PMC10169206 | 41598_2023_34641_Fig14_HTML.jpg |
0.510168 | f9c31310e23e40559a3cddee155e142a | Schematic diagram of the block model section of a small open-pit mine. | PMC10169206 | 41598_2023_34641_Fig15_HTML.jpg |
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