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0.460599 | 3dd3647e87bd4ecab8978e19c09f129a | KEGG pathway analysis based on Cytoscape software with ClueGO was used to reveal the differences and connections of the significant signaling pathways enriched in the HEV versus Mock group (A), HEV + PS versus Mock group (B), and HEV + PS versus HEV group (C) | PMC10233519 | 12985_2023_2080_Fig5_HTML.jpg |
0.457772 | 0cdaa020fa8f4a62acb8327c7249df7f | Validation of DEPs by Western blot analysis and qRT-PCR. A The expression levels of FLNA, TXN, and CYCS in Mock or HEV-infected HepG2 cells supplemented with FBS, NPS, or PS were analyzed through Western blot analysis at 4 and 24 hpi. GAPDH served as the loading control. B The relative expression levels of FLNA, TXN, and CYCS were analyzed and normalized to the expression level of GAPDH. C Knockdown of FLNA by shRNA validated by Western blot. D The relative gene expression of RIG-I in cells infected with HEV or transfected with shRNA targeting FLNA. E The copy number of HEV in HEV-infected cells transfected with or without shRNA targeting FLNA. Three independent experiments were preformed. Student’s t-test (two-tailed) was used to compare differences between two groups. *p < 0.05, **p < 0.01, ***p < 0.001 | PMC10233519 | 12985_2023_2080_Fig6_HTML.jpg |
0.452149 | 7b4b87ad1ef348109f493de0976fddd5 | NEPS Multicohort Sequence Design (MCSD) 2009–2024 | PMC10233542 | 11618_2023_1156_Fig1_HTML.jpg |
0.474553 | 564a706fc363426098ad2ce59c38ad56 | NEPS Framework | PMC10233542 | 11618_2023_1156_Fig2_HTML.jpg |
0.447686 | b866a84edaf1400fb60c68d832fb3fb4 | Postinjury radiographs at 13 years demonstrated right both-bone forearm fractures. | PMC10233633 | 10.1177_15589447221130083-fig1.jpg |
0.482834 | 3d35bb00ee9f4c2bad259854e54e38a3 | Intraoperative fluoroscopy demonstrated appropriate reduction and hardware
placement. | PMC10233633 | 10.1177_15589447221130083-fig2.jpg |
0.451369 | 4147b08144494f1299dc53686a736a97 | Radiographs at 2 months postoperatively demonstrated good hardware position. | PMC10233633 | 10.1177_15589447221130083-fig3.jpg |
0.457399 | 1d6a6943472247a1bc905ccfcaff0561 | Radiographs at 4 years postoperatively (17 years old) demonstrated proximal hardware
migration. | PMC10233633 | 10.1177_15589447221130083-fig4.jpg |
0.451709 | 26dbced4bbf044cc906be69395e4e928 | Full-arthroscopic latissimus dorsi tendon transfer. (A) Eight portals, represented in the figure by crosses, were created. The dashed line is the continuation of the line to help position the portals. Solid lines, acromion; oval lines, coracoid process. (B) Posterior view of the shoulder. Soft tissues were released medial to the long head of the triceps to access the triangular space (delimited by the long head of the triceps laterally, the teres minor superiorly, and the latissimus dorsi/teres major distally). (C) Anterior view of the shoulder. The scope was placed in an anterolateral portal, following the long head of the biceps tendon to reach the lateral edge of the conjoint tendon and the upper border of the pectoralis major, which was partially released to facilitate exposure to the latissimus dorsi tendon. | PMC10170606 | 10.1177_23259671231160248-fig2.jpg |
0.50398 | 645a3e4a548d42b3a6e76b3b843d2311 | Posterior view of the shoulder. The “double transfer” of the latissimus dorsi and teres major was fixed onto the junction between the footprints of the supraspinatus and infraspinatus using 2 knotless anchors. | PMC10170606 | 10.1177_23259671231160248-fig3.jpg |
0.486022 | 9cb97f13e93042f09e493f458e28e244 | Patient enrollment and matching. LDTT, latissimus dorsi tendon transfer; mRCT, massive rotator cuff tear. | PMC10170606 | 10.1177_23259671231160248-fig4.jpg |
0.466958 | 7161cfdfbcc54008a12b025da3e245b5 | The chlorophyll fluorescence parameters of Limonium tetragonum under different NaCl concentrations (n = 4). (A) Maximum quantum efficiency of PSII (F
v/F
m) and (B) electron transfer rate. Statistical analysis was performed with Duncan’s multiple range test. NS, non-significant. ***p = 0.001. | PMC10170659 | fpls-14-1159625-g001.jpg |
0.435608 | abbbbab75f9b4da4b9aced119352602f | The leaf water potential of Limonium tetragonum under different NaCl concentrations (n = 4). Statistical analysis was performed with Duncan’s multiple range test. ***p = 0.001. | PMC10170659 | fpls-14-1159625-g002.jpg |
0.375224 | f6a5ba7d9d4646f88016e8258c68769e | The concentration of the major compounds of Limonium tetragonum under different NaCl concentrations analyzed using LC-ESI-MS (n = 5). (A) Compound 1 (myricetin-3-O-β-D-galactoside), (B) compound 2, (C) compound 3, (D) compound 4, and (E) compound 5. Statistical analysis was performed with Duncan’s multiple range test. ***p = 0.001. N.D., non-detected. | PMC10170659 | fpls-14-1159625-g003.jpg |
0.513058 | 586c5b2763cc4effb0caab87717f1cdd | Heatmap using hierarchical clustering analysis for the top 30 most expressed genes. | PMC10170659 | fpls-14-1159625-g004.jpg |
0.368788 | 9cc7057c0535417097a15f79be53ab29 | The principal component analysis of Limonium tetragonum under different NaCl concentrations (n = 5). | PMC10170659 | fpls-14-1159625-g005.jpg |
0.420649 | 0c26540ee94549608cd66e48ca8b0be3 | Gene ontology analysis: biological processes for NaCl concentrations (n = 5). | PMC10170659 | fpls-14-1159625-g006.jpg |
0.407081 | ae576a59f27f480491b22931caeae019 | (1A) Sampling and screening of apterous Sitobion avenae on 3-week-old wheat plants. (1B) Reverse Transcriptase Polymerase chain reaction for (2A) Lac gene (615 bp) (L1) 1 Kb ladder, (L2) Lac gene. (1C) Phylogenetic tree of Lac gene (ON703252: S. avenae lac1 mRNA Partial CDS) closest homology (≥90%) by phylogeny.fr show similarity to M. persicae, A. pisum, and Diuraphis noxia. | PMC10171587 | pone.0284888.g001.jpg |
0.486491 | 9cba706d77e64e1cab23181f7c2af939 | (2A) DsRNA feeding experiment for checking the efficacy of lac gene as RNAi target. Effect of artificial diet (20% sucrose), GFP dsRNA (20 ngL-1) -ve control, and Lac gene (LAC) (7 μg/μL) (2B) Fold increase in mRNA expression (determined by of Quantitative reverse transcriptase polymerase chain reaction (qRT-PCR) of Lac gene in comparison to internal control (Actin) and -ve control (Lac without dsRNA feeding assay) 2D, 4D and 6D post-feeding. (2C) Fold change in mRNA expression in leaf, stem and root; determined by Lac gene qRT-PCR in comparison to internal control (Actin) 9D, 11D and 13D post-spraying. Means are significantly different at a 0.05 level of significance at α = 0.05. | PMC10171587 | pone.0284888.g002.jpg |
0.460229 | 64b499e76c7945b3b46705293dfe21b8 | Schematic diagram of the SaLac1 location in the ihpRNA vector.The CaMV 35S promoter, two copies of the SaLac1 gene, the Pdk intron, Bsa1, and an adapter sequence, and NOS terminator form the cassette. | PMC10171587 | pone.0284888.g003.jpg |
0.411489 | d020fb1f1fa341649203bd3e970ddc72 | (4A) Colony PCR of RNAi-GG with RNAi-GG specific primers from pdk intron region (Tm. 58; 680 bps). M (1kb Ladder), L1-3 (PCR products of RNAi-GG). (4B) Lac1 confirmation with vector-specific primers including adaptor sequences. M (1kb Ladder), L2-6 (PCR Product: 645 bps at Tm = 53) (4C) RNAi-GG digestion with SacI, and SwaI (12824, and 2948 bps): M (1kb Ladder), L1-2 (Digestion products) (4D) PCR product using P-21 + P22 primers for whole insert confirmation (3194 bps), M (1kb Ladder), L1-6 (Whole insert: 3194 bps; Tm = 55). | PMC10171587 | pone.0284888.g004.jpg |
0.41707 | 164f5e19dbbd4a0eac6ecf06822f11f1 | (5A) Lac 1 sense orientation confirmation by P-21 & 24 primers. M (1kb Ladder), L1-4 (Lac1 sense insert) (Tm = 55; 1000 bps) (5B) Lac 1 antisense orientation confirmation by P-22 and P-25 primers. M (1kb Ladder), L1-5: Lac1 antisense insert (Tm = 56; 958 bps) (5C) Lac1 antisense orientation confirmation by P-22 and Lac1 Reverse Primer. M (1kb Ladder), L1-2 (PCR antisense orientation insert) (Tm = 56; 913 bps). | PMC10171587 | pone.0284888.g005.jpg |
0.434657 | a504fdf1ce2344f09fca9c7820f6ce30 | (6A) Effect of acetosyringone concentration on transformation efficiency (6B) T. aestivum cvs Galaxy 2012, Anaj 2017, & Punjab transformation efficiency by In Vitro Assay (6C) T. aestivum cvs Galaxy 2012, Anaj 2017, & Punjab transformation efficiency by In planta Assay (6D) Lac 1 confirmation T1 Triticum aestivum cultivars. M (1kb Ladder), L1 (+ve control), L2 (-ve control), L3-4, 6 (Anaj 2017), L9-11 (Galaxy 2012), L13-15 (Punjab), L7, L8, & L12 (non-transgenic plants). | PMC10171587 | pone.0284888.g006.jpg |
0.428091 | ca0a0400b4b04474953e13c7caec74c4 | (7A) qRT-PCR relative lac 1 expression in In planta transformation. Actin was used as control. Data is presented as mean ±SE of the mean. *indicates a significant difference in Laccase1 expression in transgenic Galaxy 2012, Punjab, and Anaj 2017. No Laccase1 expression in non-transgenic Galaxy 2012, Punjab, and Anaj 2017. (7B) Insect bioassay on T. aestivum resistant cv. Zincol 2016, and Susceptible cvs. (Galaxy 2012, Anaj 2017, & Punjab). (7C) Insect bioassay on T. aestivum transgenic T1 cv. Galaxy 2012 (7CA) Before feeding and (7CB) After Feeding. | PMC10171587 | pone.0284888.g007.jpg |
0.46659 | f4ef055e58ce47b89572441e9a6e3bde | PRISMA flowchart describing the process and number of excluded/included studies. | PMC10171603 | pone.0285443.g001.jpg |
0.451151 | 203879e8cad640a68778e0318f935042 | Number of included studies in synthesis organised according to the EPOC taxonomy of delivery arrangements and a seventh category for studies with specific goals.The size of circles illustrates the number of studies in each category and subcategory. | PMC10171603 | pone.0285443.g002.jpg |
0.400765 | 57c0105de8db4f21bc8115ff28510c7d | Nature and number of outcome measures in the included studies according to EPOC outcome category. | PMC10171603 | pone.0285443.g003.jpg |
0.42391 | 9130451edf854f3ba57249d8d2bac74a | Flow chart of study design of (A) the NHIS-NSC and (B) the CDM cohort. CDM, common data model; DM, database; NHIS-NSC, national sample cohort of National Health Insurance Service; T2DM, type 2 diabetes mellitus; w/o, without. | PMC10172489 | fmed-10-1118863-g001.jpg |
0.414486 | 413c5befa40b44ea920ccfd62a22dc08 | Cumulative incidence of lung cancer in COPD patients with and without T2DM in (A) the NHIS-NSC and (B) the CDM cohort. CDM, common data model; NHIS-NSC, national sample cohort of National Health Insurance Service; T2DM, type 2 diabetes mellitus; w/o, without. | PMC10172489 | fmed-10-1118863-g002.jpg |
0.409846 | 94de07f46e5a445e9fd5f44efcc61359 | Hazard ratios for lung cancer risk in COPD patients with T2DM compared with those without T2DM in (A) the NHIS-NSC and (B) the CDM cohort. BMI, body mass index; CCI, Charlson Comorbidity Index; CDM, common data model; NHIS-NSC, national sample cohort of National Health Insurance Service; R. area, residential area; ref., reference; T2DM, type 2 diabetes mellitus; w/o, without. | PMC10172489 | fmed-10-1118863-g003.jpg |
0.391581 | 9646538757724f7dba21be0a949db74a | NPQ induction and relaxation in Col-0, hhl1, VIGS-PSBS (Col-0), and VIGS-GFP (hhl1), NPQ induction curves of 4-week-old Arabidopsis Col-0, hhl1, VIGS-GFP(Col-0), VIGS-PSBS (Col-0), VIGS-GFP (hhl1) and VIGS-PSBS (hhl1) grown under growth-light conditions, induced by treatment with actinic light at 500 μmol photons·m−2·s−1for 10 min, and relaxed in the dark for 10 min.A, the saturation pulse was applied every 30 s. C, false-colored image of NPQ in plants after 10 min of actinic light treatment. Scale bar, 1 cm. B and E, NPQ kinetics curve. D, silencing efficiency of PsbS in VIGS plants, means ± SD, Error bars represent SD of three biological repeats (∗∗∗P < 0.001, Student’s t test). NPQ, nonphotochemical quenching; VIGS, virus-induced gene silencing. | PMC10173003 | gr1.jpg |
0.419688 | 0cb41a03363649da8925729028d1f738 | BiFC and yeast two-hybrid (Y2H) analysis of the interaction of HHL1 and SOQ1.A, BiFC assay. HHL1 was cloned into the YN vector, and SOQ1 was cloned into the YC vector. The vectors were cotransformed into Arabidopsis protoplasts, and fluorescence was observed by confocal microscopy. bZIP63-YN + bZIP63-YC and HHL1-YN + LQY1-YC were used as positive controls; YN and SOQ1-YC were used as the negative control. Scale bar, 10 μm. B, Y2H analysis. HHL1 was cloned into the BD vector to form a fusion protein expression vector (HHL1-BD), and SOQ1 was cloned into the AD vector to form a fusion protein expression vector (SOQ1-AD). HHL1-BD and SOQ1-AD were cotransformed into yeast strain Y2H Gold; HHL1-BD and AD, and SOQ1-AD and BD were used as negative controls. C, the 10-day-old transgenic Arabidopsis seedlings expressing SOQ1-FLAG and the purified His-HHL1 fusion protein were used for the Co-IP assay. Two additional independent biological replicates were performed with similar results. BiFC, bimolecular fluorescence complementation; Co-IP, co-immunoprecipitation; HHL1, hypersensitive to high light 1; SOQ1, suppressor of quenching 1. | PMC10173003 | gr2.jpg |
0.373811 | 254072943fe24ec98dde43d541b128ad | Identification and phenotypic analysis of the hhl1 soq1 double mutant, NPQ kinetic curves of 4-week-old Arabidopsis Col-0, hhl1, soq1, and hhl1 soq1 plants under growth-light conditions, followed by induction with 500 μmol photons·m−2·s−1actinic light for 10 min and relaxation in the dark for 10 min; the saturation pulse was applied every 30 s.A, false-colored image of NPQ in plants following 10 min of actinic light induction. Scale bar, 1 cm. B, molecular identification of hhl1 soq1. hhl1 is a transfer-DNA insertion mutant, which was identified by the three-primer method, and soq1 contains a single point mutation in which the base before the sixth exon was mutated from G to A, as identified by sequencing. C, NPQ kinetics curves. Error bars represent SEM of six biological repeats. NPQ, nonphotochemical quenching. | PMC10173003 | gr3.jpg |
0.416046 | d0639c9534b04b4884530e0595927e27 | Analysis of HHL1 protein levels in soq1.A, thylakoid membrane proteins were isolated from 14-day-old Arabidopsis Col-0, soq1-1, and soq1-5 plants, separated by 15% SDS-PAGE, and subjected to immunoblotting with affinity-purified HHL antibody. ATPB (ATP synthase complex β subunit) and Coomassie Brilliant Blue (CBB) staining were used to ensure equal loading. B, quantitative analysis of HHL1 protein levels. Values are means ± SD of three replicates, (∗p < 0.05, Student’s t test). C, false-colored image of NPQ in plants after 10 min of actinic light induction. Scale bar, 1 cm. D, identification of proteins in hhl1:SOQ1 OE and soq1:HHL1 OE lines. E, NPQ kinetic curves of 4-week-old Arabidopsis Col-0, hhl1, soq1, hhl1:SOQ1 OE, and soq1:HHL1 OE under growth-light conditions, followed by induction with 500 μmol photons·m−2·s−1 of actinic light for 10 min and relaxation in the dark for 10 min; the saturation pulse was applied every 30 s. Error bars represent SEM of six biological repeats. HHL1, hypersensitive to high light 1; NPQ, nonphotochemical quenching; SOQ1, suppressor of quenching 1. | PMC10173003 | gr4.jpg |
0.389724 | 81516b55f0bd40feb0dc1d284ca86783 | Analysis of LCNP in the mutants, the function of the HHL1 VWA domain in the SOQ1 interaction, and the regulation of LCNP.A, After the high-light (500 μmol photons·m−2·s−1) and cold (4 °C) treatments in Col-0, hhl1, soq1, and hhl1 soq1 for 5 h, protein was extracted and used for immunoblotting analysis. The anti-LCNP antibody was used to detect the protein level, and CBB was used for equal quantifying loading. Two independent biological replicates were performed with similar results. The red star represents the mobility protein band, the blue star represents the unmobility protein band. B, BiFC assay. The relevant vectors were cotransformed into Arabidopsis protoplasts, and fluorescence was observed by confocal microscopy. Scale bar, 10 μm. C, Co-IP assay. Protoplasts from 25-day-old transgenic Arabidopsis plants expressing SOQ1-FLAG were cotransformed with HHL1-nYFP (MYC tag) or HHL1-NVWA-nYFP. D, HHL1-NVWA-nYFP or HHL1-nYFP and SOQ1-nYFP were cotransformed into hhl1 soq1 mesophyll protoplasts; anti-MYC, anti-HA, and anti-LCNP antibodies were used to detect the protein levels. The arrow represents the target band. At least two independent biological replicates were performed. BiFC, bimolecular fluorescence complementation; CBB, Coomassie Brilliant Blue; Co-IP, co-immunoprecipitation; HHL1, hypersensitive to high light 1; LCNP, plastidial lipoprotein; NPQ, nonphotochemical quenching; SOQ1, suppressor of quenching 1; VWA, von Willebrand factor type A. | PMC10173003 | gr5.jpg |
0.460522 | 1798ccd360084561904b53a879d11591 | Identification and phenotypic analysis of hhl1:HHL1 OE and hhl1:HHL1-NVWA OE, NPQ kinetic curves of 4-week-old hhl1:HHL1 OE and hhl1:HHL1-NVWA OE plants. The plants were grown under growth-light conditions, induced with 500 μmol photons·m−2·s−1 actinic light for 10 min, and relaxed in the dark for 10 min; the saturation pulse was applied every 30 s. A, false-colored images of NPQ in plants after 10 min of actinic light induction. Scale bar, 1 cm. B, identification of proteins in hhl1:HHL1 OE and hhl1:HHL1-NVWA OE lines. C, NPQ kinetics curve. Error bars represent SEM of six biological repeats. HHL1, hypersensitive to high light 1; NPQ, nonphotochemical quenching. | PMC10173003 | gr6.jpg |
0.471742 | 6b3f90958f5f48fe9bfe02f50ecd2acf | Proposed working model of the synergy between HHL1 and SOQ1 in the regulation of NPQ. On the lumenal side of the thylakoid membrane, HHL1 mainly interacts with SOQ1 through the VWA domain. Then, SOQ1 might provide reducing power to its target proteins, such as LCNP, and decrease oxidative modifications of LCNP, which is required to suppress qH (left). Meanwhile, HHL1 regulates NPQ via an unknown mechanism (right) to maintain normal plant growth. HHL1, hypersensitive to high light 1; LCNP, plastidial lipoprotein; NPQ, nonphotochemical quenching; SOQ1, suppressor of quenching 1; VWA, von Willebrand factor type A. | PMC10173003 | gr7.jpg |
0.497866 | e34157aaa260450d8d40678c63f3caca | Participant inclusion flowchart. | PMC10173387 | gr1.jpg |
0.420933 | 9d5cb7a8511e4a1ebd98401e2aa4885e | Totally thoracoscopic mitral Valve Annuloplasty procedure. MA, Mitral annulus; PM, Papillary muscles. | PMC10173624 | gr1.jpg |
0.410616 | b1524a9c1a274cfea52309f63429e488 | Schematic representation of the operating room layout for totally thoracoscopic Cardiac Surgery. AN, Anesthesiologist; SU, Surgeon; SN, Scrub nurse; A1, A2, 1st and 2nd assistant; PE, Perfusionist; MIP, Multichannel infusion pump; TEE, Transesophageal echocardiography; DFA, display for 1st assistant. | PMC10173624 | gr2.jpg |
0.404896 | 6c379727a0d74ce7bca26120beb6a106 | Intraoperative transesophageal echocardiography. LV, Left ventricle; RV, Right ventricle; MV，Mitral valve. | PMC10173624 | gr3.jpg |
0.448636 | 127f16fdec364888bd0230af84c7913c | Fibreoptic bronchoscopy guided left-double lumen endotracheal intubation. | PMC10173624 | gr4.jpg |
0.417101 | f95f3c2252ec4c06beda7c210a9cbd95 | Ultrasound guided Serratus anterior block procedure. | PMC10173624 | gr5.jpg |
0.51635 | 6197d72e00d242e8a3cd630b7d0a3681 | When intraoperative persistent hypoxemia occurs, 1/2 of the right bronchial tube was clamped with Vascular Clamps. | PMC10173624 | gr6.jpg |
0.452725 | d965834f293e466b80c2d59cbb03ac76 | Participants’ enrollment flowchart | PMC10174730 | 423_2023_2932_Fig1_HTML.jpg |
0.431207 | 0d8aa37eb8f64778b52315505fb29264 | Residual pain any intensity | PMC10174730 | 423_2023_2932_Fig2_HTML.jpg |
0.425473 | a41f8881704f402190a8064d8f72bc1b | Residual pain moderate and severe intensity | PMC10174730 | 423_2023_2932_Fig3_HTML.jpg |
0.455004 | 03bdb11f0cb943e59def82816c21ffd1 | Residual pain severe intensity | PMC10174730 | 423_2023_2932_Fig4_HTML.jpg |
0.39075 | 22367346f7774fe4870e7dfd2f970251 | Categories of RNA molecules identified in COVID and control group tissue samples. Long intergenic noncoding RNA (lincRNA), microRNA (miRNA), small nuclear RNA (snRNA), small nucleolar RNA (snoRNA), pseudogene, antisense, and other miscellaneous RNA categories. | PMC10174733 | gr1_lrg.jpg |
0.42284 | 48fde822753b42c0a3145e06e00c95a9 | Differentially expressed protein coding genes in dental pulp tissues of COVID and control groups. (A) Volcano plot showing differential expression of protein coding genes. Green dots indicate significant differential expression. Red dots indicate nonsignificant expression. (B) Heatmap showing expression of the top upregulated and downregulated protein coding genes in COVID and control tissue samples. Color key represents the Z-score ranging from −4 to 4 with negative Z-scores corresponding to shades of red and positive Z-scores corresponding to shades of blue. | PMC10174733 | gr2_lrg.jpg |
0.419142 | 9a9e14e1081541bb8a7cdff332a45709 | Protein coding genes identified as differentially expressed. (A) Genes with known proinflammatory, angiogenesis, and wound healing functions. (B) Genes with known anti-inflammatory functions. Upregulated genes are shown in blue, whereas downregulated genes are shown in orange (differentially expressed gene significant threshold P ≤ .05 and 2-fold change). | PMC10174733 | gr3_lrg.jpg |
0.433899 | 68c6616af6e64852b4b3f34e976f063d | A, B, C) X-ray presentation of kyphoscoliosis | PMC10175649 | PAMJ-44-64-g001.jpg |
0.418673 | c299f33c42424686a03182c8186e6c64 | Clinical features of cases of dengue fever in Muscat Governorate, March–April 2022. | PMC10176167 | gr1.jpg |
0.393602 | 6f83536ee370478f8743c5a13c4a2ab4 | Epidemic curve of outbreak of dengue fever in Muscat Governerate, March–April 2022. | PMC10176167 | gr2.jpg |
0.429574 | 6f822a8a3bd34fc6b65ad9e6d3f22452 | Map of Greater Muscat from As-Seeb district to Mutrah districts. Red dots indicate the breeding sites identified by entomological investigations in As-Seeb, Baushar, Amerat and Mutrah districts. | PMC10176167 | gr3.jpg |
0.459498 | 19b1d54c2aa4461f83840fe6973f9d84 | Preparation of shoot tips.A. Dissecting microscope images of the 9-day-old plant. Scale bar: 1,000 μm. B. Dissecting microscope images of the shoot tips with hypocotyl. Scale bar: 1,000 μm. White dashed lines mark the base of petiole. Cut the cotyledons and root along the dashed lines using a single edge blade. C. Centrifuge tube containing shoot tips (green) in fixative solution. D. Centrifuge tube containing shoot tips (white) in 100% ethanol. | PMC10176207 | BioProtoc-13-09-4672-g001.jpg |
0.421266 | cd96516c92bc415fabc61ef4e22a0e53 | Dissection of shoot tips.A. Round culture dish containing shoot tips in 100% ethanol. B. Dissection of shoot tips using a syringe needle or tweezers under the dissecting microscope. C. Dissecting microscope images of the shoot tips before dissection. The arrow indicates the hypocotyl; white dashed lines mark the base of petiole. Scale bar: 500 μm. D. Images of the shoot tips from the top before dissection. White dashed lines mark the base of petiole. Scale bar: 500 μm. Grip the hypocotyl of shoot tips with tweezers and remove the leaves along the dashed line using a syringe needle or tweezers. E. Dissecting microscope images of the shoot tips after dissection. Scale bar: 500 μm. | PMC10176207 | BioProtoc-13-09-4672-g002.jpg |
0.40332 | 0090763d05964b63a699d284d50ad180 | Staining of shoot tips.A. Centrifuge tube containing shoot tips in pseudo-Schiff propidium iodide solution. The shoot tips are pink. B. Dissecting microscope images of the shoot tips during chloral hydrate solution treatment. Scale bar: 500 μm. C. Microscope slide with shoot tips in chloral hydrate solution. The arrow indicates the shoot tip. D. Microscope slide with shoot tips in Hoyer′s solution. The arrow indicates the shoot tip. | PMC10176207 | BioProtoc-13-09-4672-g003.jpg |
0.381922 | 45695d463fb14f219d3303341b80f4cf | Imaging of shoot tips.Series of SAM images with different z-axis obtained using a laser scanning confocal microscope. The arrow indicates the SAM; P indicates the leaf primordia; Z indicates different z-axis; white dashed lines in Z10 mark the cell layers. Scale bar: 50 μm. | PMC10176207 | BioProtoc-13-09-4672-g004.jpg |
0.470699 | 813a785de6a44758b9c466b922e294d6 | The study flowchart. | PMC10177902 | healthcare-11-01335-g001.jpg |
0.423084 | ab6d27ad99a94b85a9329bdb193cd361 | Two scenarios for static and dynamic balance training with VR. (a): patient using FisioVR device, and (b): scenario that patient visualizes. | PMC10177902 | healthcare-11-01335-g002.jpg |
0.437848 | 4d12570beaf54bdfa9baa634c85311b1 | Immersive Virtual Reality scenarios. | PMC10177902 | healthcare-11-01335-g003.jpg |
0.410734 | e79b5e5ad92447e3989af2ea3b81d1d2 | SWIR-HSI acquisition system and three-dimensional (3D) data cube. (A) Box with black inner surface; (B) Imaging Spectrograph; (C) Lens; (D) Light source regulator; (E) Halogen lamps; (F) Sample of Hami melon; (G) Lifting platform; (H) Electric moving stage. | PMC10178042 | foods-12-01773-g001.jpg |
0.467309 | 7102c3670b204db896cf800873ffad4e | tHBA-ELM Algorithm Flow Chart. | PMC10178042 | foods-12-01773-g002.jpg |
0.471455 | e94eb4965dca46db92e55510eb217774 | Raw spectra and average reflectance spectra. (a) raw spectra; (b) average reflectance spectra.3.2 Establishment and analysis of classical machine learning classification model. | PMC10178042 | foods-12-01773-g003.jpg |
0.364404 | bff2387a63c44c489d5244aff57415e1 | ELM and the improved ELM model confusion matrix. (a) NM-ELM; (b) NM-GA-ELM; (c) NM-HBA-ELM; (d) NM-tHBA-ELM. | PMC10178042 | foods-12-01773-g004.jpg |
0.43037 | 44d2b3bd41fb4ea6bad7f78abb6ba815 | Optimization process of GA-ELM, HBA-ELM, and tHBA-ELM. | PMC10178042 | foods-12-01773-g005.jpg |
0.56635 | ae87515b181c487487a9a87bec4d4fd3 | Crystal structure of compound 3a (CCDC 2225696). All atoms are color-labeled as red (oxygen), blue (nitrogen), gray (carbon), white (hydrogen). (see Table S1 for the crystal data and structure refinement for 3a). | PMC10178506 | ijms-24-07724-g001.jpg |
0.443021 | f7e2758f5bb1484ab877a1439546d795 | X-ray crystal structure of 7c (crystallized with MeOH) (a) and related unit cell (b). All atoms are color-labeled as yellow (bromine), red (oxygen), blue (nitrogen), gray (carbon), white (hydrogen). (see Table S2 for the crystal data and structure refinement for 7c). | PMC10178506 | ijms-24-07724-g002.jpg |
0.469322 | aacebd3e06b74ee5890e5505641b3505 | Cis-decalin geometry of the six-membered cycles in 7c (CCDC 2224256). Color labels as in Figure 2. | PMC10178506 | ijms-24-07724-g003.jpg |
0.470375 | e1d961e7330c4223a5c35369aed12511 | Trans-decalin geometry of the fused six-membered cycles in 8a molecule (CCDC 2224240). All atoms are color-labeled as red (oxygen), blue (nitrogen), gray (carbon). (see Table S3 for the crystal data and structure refinement for 8a). | PMC10178506 | ijms-24-07724-g004.jpg |
0.424608 | 60cc34bf39e744fb8ab40f56994723d6 | Michaelis–Menten curves of the inhibition kinetics of hMAO B (kynuramine as the substrate) in the absence (black circles) or in presence of the inhibitors 3b (left) and 6c (right) at three scalar concentrations (insets); each data point is the average value of at least two measurements. | PMC10178506 | ijms-24-07724-g005.jpg |
0.426344 | 35918f34dc594de1ad0a4a220ea0c9ca | Synthesis of 1,2,3,4-tetrahydro-(1) and 2,3-dihydrochromeno[3,2-c]pyridine (2) derivatives. | PMC10178506 | ijms-24-07724-sch001.jpg |
0.528453 | 476d88212875480180ebcc5cb1afb9ed | Alkynylation of 1,2,3,4-tetrahydrochromeno[3,2-c]pyridin-10-ones (1). | PMC10178506 | ijms-24-07724-sch002.jpg |
0.51779 | 252525b7e7c6449ba02a1a5441dd0b20 | Mechanism of alkynylation of 2-alkyl-THCP-10-one 1. | PMC10178506 | ijms-24-07724-sch003.jpg |
0.455856 | a5fdc95ebb664f22b87d03e1929bcd36 | Reaction of 2,3-dihydrochromeno[3,2-c]pyridines with diverse nucleophiles. | PMC10178506 | ijms-24-07724-sch004.jpg |
0.474164 | b13bfedb58794e6a8dcaf7442dd565f4 | Mechanism of the nucleophilic addition onto C10 of DHCP. | PMC10178506 | ijms-24-07724-sch005.jpg |
0.476787 | b4186db9bdd24d639594ea18c8068c92 | Three-component synthesis of 6a, with predominant formation of hemiacetal 7a. | PMC10178506 | ijms-24-07724-sch006.jpg |
0.467055 | 5bf1f9df079c4f7d85fba337853af17b | Synthesis of hemiacetals 7a–f. | PMC10178506 | ijms-24-07724-sch007.jpg |
0.440392 | fa863650b5164c4587b43b2168e67024 | Mechanism of formation of hemiacetals 7. | PMC10178506 | ijms-24-07724-sch008.jpg |
0.566937 | c5bb23d6866b45bc9e4ab5318bf0d568 | Synthesis of hemiacetals 8a–e without l-proline. | PMC10178506 | ijms-24-07724-sch009.jpg |
0.502625 | fb6d45bab71749b9a71d84b30cb0e630 | Mechanism of the synthesis of compounds 8. | PMC10178506 | ijms-24-07724-sch010.jpg |
0.477804 | 92225e88e7d34ea2a037f1ba6410b8ee | Manhattan plot of GWAS of sweet liking on 1482 individuals from the discovery cohort (Val Borbera and Carlantino). The red line is set at p-value = 5 × 10−8, and the SNPs above the line were selected for the replication step. The blue line is set at p-value = 1 × 10−5, and the results for the SNPs above this line are shown in Table S2. Manhattan plot was generated with the R library qqman [55]. | PMC10178705 | foods-12-01739-g001.jpg |
0.538562 | acf2f7a7d26d43d5b494a60de388178a | Association plot for the region around rs58931966 in the discovery sample. The purple diamond demonstrates the most strongly associated SNP, rs58931966, near the RGS9 gene. The minus logarithm of single nucleotide polymorphism (SNP) association p-value is shown on the y-axis and the SNP position (with gene annotation) on the x-axis. For each SNP, the strength of LD with the lead SNP is colour-coded by its r2. The plot was produced in LocusZoom [56]. | PMC10178705 | foods-12-01739-g002.jpg |
0.429401 | f5919f9eedde417f85700ce5bb298757 | (a) Tissue-specific expression (GTEx v8) of RGS9 gene; (b) association of the strongest SNP rs58931966 with the expression of RGS9 gene on the pituitary tissue (splicing quantitative locus). TMP = transcripts per million. | PMC10178705 | foods-12-01739-g003.jpg |
0.467303 | 56fb3de0682d4eec84dbdc0719769d03 | SEM models (Lavaan R package) for sweet liking and food adventurousness (FA). Reported value are βs and p-values (* p-value < 0.05, ** p-value < 0.01, *** p-value < 0.001, NS = not significant). Pop = population (Carlantino, Val Borbera, Friuli Venezia Giulia). The model has a good fit (CFI = 0.995, TLI = 0.954, p-value Chi-square = 0.094, RMSEA = 0.025). The relationship of the SNP with sweet liking was both direct and mediated by FA (Sobel test, z = 2.04, p-value= 0.041). | PMC10178705 | foods-12-01739-g004.jpg |
0.418394 | 116096f3ece3415fb101c3e01c3285ec | The role of myeloperoxidase in modulating inflammatory responses in gastrointestinal epithelium. This exemplar image illustrates the invasion of pathogens into the colon wall that stimulates the recruitment of immune cells. Release of the haem enzyme MPO from neutrophils, monocytes and macrophages, which in turn catalyses the production of the potent bactericidal agent hypochlorous acid (HOCl). In addition, HOCl interacts with, but is not limited to, matrix metalloproteinases (MMPs) S100 “calgranulin” proteins (such as calprotectin) to modulate commensal floral population, control inflammatory responses and limit bacterial growth. Similar inflammatory responses can be established in the vasculature, joints and other organs in the presence of varying pathogenic stimuli. HOCl: hypochlorous acid; MMPs: matrix metalloproteinases; MPO: myeloperoxidase. Illustration created with www.Biorender.com with appropriate licensing (accessed 20 April 2023). | PMC10178760 | ijms-24-07725-g001.jpg |
0.469685 | 308c154fdb0f45358e1a182e178cab13 | The entire selection and screening procedures are described in the PRISMA flowchart; tables with the orange lines are the searches performed subsequently (on 16 April 2022), with the addition of new keywords on PubMed. | PMC10178920 | jcm-12-03299-g001.jpg |
0.517396 | 654d046b6b964f08a10ac005f8b15105 | Binary random effects model metric; odds ratio: 1.390; C.I. (Confidence Interval): (lower bound) 0.801 (upper bound) 2.412; p-value 0.241; Q = Q statistic (measure of weighted squared deviations); df = degrees of freedom; I2 (I^2) = Higgins heterogeneity index, I2 < 50%, heterogeneity low; P = p value; heterogeneity (Het.): tau^2: 0.315; Q (df = 13) 20.178, Het. p-value: 0.091, I^2: 35.574; Results (log scale): 0.329 (−0.221, 0.880), Standard error (SE): 0.281; Weights: Jeong: 10.945%, Lain and Ajwani: 16.231%, Hasegawa: 18.572%, Ferlito: 1.814%, Lazarovici: 12.918%, Lodi: 1.760%, Mozzati 2013: 1.829%, Mozzati 2012: 3.154%, Scoletta 2013: 2.887%, Scoletta 2011: 3.140%, Vescovi: 5.024%, Kang: 2.646%, Kawakita: 8.692%, Bodem: 10.390%. Correction factor = 0.5 (applied only to values of 0). The graph of each study shows the first author and the date of publication as well as the measurement of the number of MRONJs on the total and the relative OdRa with the confidence intervals reported. The final value with the relative confidence intervals is expressed in bold. Jeong et al., 2017 [36], Lain and Ajwani, 2016 [37], Hasegawa et al., 2017 [22], Ferlito et al., 2011 [38], Lazarovici et al., 2010 [40], Lodi et al., 2010 [41], Mozzati et al., 2013 [43], Mozzati et al., 2012 [44], Scoletta et al., 2013 [48], Scoletta et al., 2011 [49], Vescovi et al., 2013 [50], Kang et al., 2020 [52], Kawakita et al., 2017 [53], Bodem et al., 2015 [55]. | PMC10178920 | jcm-12-03299-g002.jpg |
0.442055 | 1d1e22a8dfd444579dbd7f39767b0b2f | Forest plot analysis subgroup; subgroup OR: 6 studies, OdRa: 1.718 (0.889, 3.317), SE: 0.336, p-Val: 0.107, z-Val: 1.611, Q (df): 8.371 (5), Het. p-Val: 0.137, I^2: 40.27%; Subgroup IV: 6 studies, OdRa: 1.325 (0.367, 4.77), SE: 0.654, p-Val: 0.667, z-Val: 0.430, Q (df): 6.774 (5), Het. p-Val: 0.238, I^2: 26.19%; Subgroup OR IV: 2 studies, OdRa: 0.774 (0.157, 3.807), SE: 0.813, p-Val: 0.752, z-Val: −0.316, Q (df): 1.362 (1), Het. p-Val: 0.243, I^2: 26.57%. Jeong et al., 2017 [36], Lain and Ajwani, 2016 [37], Hasegawa et al., 2017 [22], Ferlito et al., 2011 [38], Lazarovici et al., 2010 [40], Lodi et al., 2010 [41], Mozzati et al., 2013 [43], Mozzati et al., 2012 [44], Scoletta et al., 2013 [48], Scoletta et al., 2011 [49], Vescovi et al., 2013 [50], Kang et al., 2020 [52], Kawakita et al., 2017 [53], Bodem et al., 2015 [55]. | PMC10178920 | jcm-12-03299-g003.jpg |
0.526367 | f1b4da00272e4a928cb28b37eee76007 | Binary random effects model: OdRa: 0.730 (0.250, 2.137), p-value: 0.566, tau^2: 0.996, Q (df = 4): 15.165, Het. p-value: 0.004, I^2: 73.624. Results (log scale) −0.314 (−1.388, 0.760) SE: 0.548. weights: Jeong: 23.420%, Lain and Aiwani: 23.784%, Hasegawa: 24.489%, Lazarovici: 22.588%, Lodi: 5.718%. Jeong et al., 2017 [36], Lain and Ajwani, 2016 [37], Hasegawa et al., 2017 [22], Lazarovici et al., 2010 [40], Lodi et al., 2010 [41]. | PMC10178920 | jcm-12-03299-g004.jpg |
0.405163 | 0fec9e2dfb5842198792b83a0ec00aa1 | Binary random effects model: OdRa: 1.476 (0.684, 3.184), p-value: 0.321, tau^2: 0.692, Q (df = 13): 21.049, Het. p-value: 0.072, I^2: 38.239. Results (log scale) 0.389 (−0.380, 1.158) SE: 0.392; Weights: Jeong: 5.444%, Lain and Ajwani: 15.968%, Hasegawa: 16.599%, Hutcheson et al.: 7.585%, Migliorati: 4.414%, Mozzati 2013: 3.250%, O’Connell: 2.849%, Saia: 9.539%, Scoletta 2013: 4.480%, Scoletta 2011: 7.590%, Vescovi: 7.785%, Kang: 4.549%, Kawakita: 5.398%, Kunchur: 4.550%. Jeong et al., 2017 [36], Lain and Ajwani, 2016 [37], Hasegawa et al., 2017 [22], Hutcheson et al., 2014 [39], Migliorati et al., 2013 [42], Mozzati et al., 2013 [43], O’Connell et al., 2012 [46], Saia et al., 2010 [47], Scoletta et al., 2013 [48], Scoletta et al., 2011 [49], Vescovi et al., 2013 [50] Kang et al., 2020 [52], Kawakita et al., 2017 [53], Kunchur et al., 2009 [21]. | PMC10178920 | jcm-12-03299-g005.jpg |
0.4688 | 91e92bb96dd64f6b81aa57212e7bcf0b | Funnel plot and forest plot (RevManger 5.4): OR, odds ratio; SE, standard error. Graphically, there are no sources of heterogeneity. The odds ratio value mirrors Figure 2, a correction factor d of 1 was applied to studies with mandibular and maxillary MRONJ events equal to 0. Jeong et al., 2017 [36], Lain and Ajwani, 2016 [37], Hasegawa et al., 2017 [22], Ferlito et al., 2011 [38], Lazarovici et al., 2010 [40], Lodi et al., 2010 [41], Mozzati et al., 2013 [43], Mozzati et al., 2012 [44], Scoletta et al., 2013 [48], Scoletta et al., 2011 [49], Vescovi et al., 2013 [50], Kang et al., 2020 [52], Kawakita et al., 2017 [53], Bodem et al., 2015 [55]. | PMC10178920 | jcm-12-03299-g006.jpg |
0.488679 | 0eab4963f5d04cd9adae1c5f3ed58ebb | TSA: Red lines represent the sequential trial monitoring limits and futility limits. The solid blue line is the cumulative Z-curve that requires the information dimension to demonstrate or reject a 20% relative increase in benefit at the maxillary versus mandibular extraction site (5% alpha and 80% beta), whose results included 13,543 patients (vertical red line). The cumulative Z-curve not crossing the Z line (horizontal red line), Z = 1.96, indicates an absence of evidence because the meta-analysis included fewer patients than the required information size, which is a false negative result. Jeong et al., 2017 [36], Lain and Ajwani, 2016 [37], Hasegawa et al., 2017 [22], Ferlito et al., 2011 [38], Lazarovici et al., 2010 [40], Lodi et al., 2010 [41], Mozzati et al., 2013 [43], Mozzati et al., 2012 [44], Scoletta et al., 2013 [48], Scoletta et al., 2011 [49], Vescovi et al., 2013 [50], Kang et al., 2020 [52], Kawakita et al., 2017 [53], Bodem et al., 2015 [55]. | PMC10178920 | jcm-12-03299-g007.jpg |
0.404177 | 772b4c03c5fb4ce385d7c9dc87f9127d | Expression of osteogenesis-related marker genes (a,b) and genes encoding ECM proteins (c,d) in ESsT and CTG samples. An ESsT and a CTG sample were harvested from the same patient and stored in RNAlater for 18–20 h before tissue homogenization, Proteinase K-treatment, and RNA extraction. Total RNA was subsequently used in qRT-PCR analyses of (a) COL1A1, SPP1, RUNX2, ALPL, (b) DLX5, IBSP, BGLAP2, PHEX, (c) COL1A2, COL3A1, POSTN, (d) FN1, VIM, and TNC transcripts normalized to GAPDH in the ESsT and CTG samples. Data represent means ± SD for 6 patients and significant differences between the two groups, *** p < 0.001, ** p < 0.01, * p < 0.05, ns = not significant are shown. | PMC10179638 | ijms-24-08239-g001.jpg |
0.503934 | 3681f646328847218efd033aa6227fd3 | Significantly increased expression of genes encoding TGF-β1 and its receptors in subepithelial palatal CTG compared to ESsT coincides with high expression of IGF1 transcript in both tissues. qRT-PCR analyses of (a) TGFB1, TGFB2, TGFB3, TGFBR1, and TGFBR2 and (b) IGF1, IGF2, IGFR1, and IGFR2 transcripts normalized to GAPDH in the ESsT and CTG samples. Means ± SD for 6 patients and significant differences between the two groups, ** p < 0.01, ns = not significant are shown. | PMC10179638 | ijms-24-08239-g002.jpg |
0.434532 | 9fa9348cbbd14753b1bfd80b1d5f9148 | Cyclic strain applied to primary mesenchymal cells originating from ESsT and CTG tissues induces TGF-β1 and IGF-1 expression reflecting the differences in the growth factor gene expression observed at a tissue level. (a) Schematic representation of culture conditions. ESsT-Cs and CTG-Fs were cultured on fibronectin-coated silicone membranes in BioFlex® culture plates in 0.3% serum-containing medium for 24 h before applying intermittent equibiaxial cyclic strain according to the loading cycles depicted under test conditions 1 and 2. In brief, the cells of the two cell types were either left at rest (control condition) or subjected to a 7- or 10-h loading cycle consisting of 1-h cyclic strain with 10% amplitude at a frequency of 1 Hz, alternating with 2-h rest intervals for a total of 7 or 10 h, respectively. Cell culture supernatant and pelleted cells were used in subsequent analyses at a protein and mRNA level, respectively. (b) Analyses of TGF-β1 and IGF-1 protein content in culture supernatants of ESsT-Cs and CTG-Fs at rest or after cyclic strain application, as indicated in (a). Values normalized to DNA content, to compensate for potential differences in the cell proliferation rate, are expressed relative to the values of control ESsT-Cs at rest. Data represent means ± SD from six independent experiments performed with primary ESsT-C and CTG-F cells from six different donors. Significant differences to the ESsT-Cs at rest unless otherwise indicated, *** p < 0.001, ** p < 0.01, * p < 0.05 are shown. (c) qRT-PCR analyses of TGFB1 and IGF1 mRNA levels. Values normalized to GAPDH are expressed relative to the values of resting ESsT-Cs. Data and statistical significance are presented as in (b). | PMC10179638 | ijms-24-08239-g003.jpg |
0.439709 | c2eaa31e638c47f19ac5bbb733229c57 | Cyclic strain causes strong induction of osteogenic marker gene expression in ESsT-C but not in CTG-F cells. Cyclic strain was applied to primary ESsT-Cs and CTG-Fs, as presented in Figure 3a. Total RNA was extracted from pelleted cells and qRT-PCR was performed for analyzing (a) COL1A1, SPP1, RUNX2, and ALPL and (b) DLX5, IBSP, BGLAP2, and PHEX transcripts normalized to GAPDH. Data represent means ± SD from six independent experiments performed with primary ESsT-Cs and CTG-Fs from six different donors. Significant differences to the respective resting control unless otherwise indicated, *** p < 0.001, ** p < 0.01, * p < 0.05 are shown. | PMC10179638 | ijms-24-08239-g004.jpg |
0.409238 | 02ed7c47f335418b9543e025b6915898 | Matrix stiffness triggers TGF-β1 and IGF-1 expression in ESsT-Cs and CTG-Fs, thus reflecting the differences in the growth factor gene expression observed at a tissue level. (a) Schematic representation of native tissues and organs with their corresponding elastic moduli. (b) Analyses of TGF-β1 and IGF-1 protein content in culture supernatants of ESsT-Cs and CTG-Fs cultured on fibronectin-coated polyacrylamide hydrogels with a stiffness corresponding to either 0.5 (compliant), 12 (stiff), or 50 (very stiff) kPa elastic modulus. Values normalized to DNA content, to compensate for potential differences in the cell proliferation rate, are expressed relative to the values of control ESsT-Cs grown on 0.5 kPa matrices. Data represent means ± SD from six independent experiments performed with primary ESsT-C and CTG-F cells from six different donors. Significant differences to the ESsT-C on 0.5 kPa matrices unless otherwise indicated, *** p < 0.001, ** p < 0.01, * p < 0.05 are shown. (c) qRT-PCR analyses of TGFB1 and IGF1 mRNA levels. Values normalized to GAPDH are expressed relative to the values of ESsT-Cs grown on 0.5 kPa matrices. Data and statistical significance are presented as in (b). | PMC10179638 | ijms-24-08239-g005.jpg |
0.429267 | 35ca80abff7042318b6dc2db59fb66d8 | Induction of osteogenic marker gene expression in ESsT-Cs strongly depends on the matrix stiffness. Total RNA was extracted from primary ESsT-Cs and CTG-Fs cultured on fibronectin-coated polyacrylamide hydrogels with a stiffness corresponding to either 0.5 (compliant), 12 (stiff), or 50 (very stiff) kPa elastic modulus (cf. Figure 5a) and qRT-PCR was performed for analyzing (a) COL1A1, SPP1, RUNX2, and ALPL and (b) DLX5, IBSP, BGLAP2, and PHEX transcripts normalized to GAPDH. Data represent means ± SD from six independent experiments performed with primary ESsT-C and CTG-F cells from six different donors. Significant differences to the respective control lines grown on 0.5 kPa matrices unless otherwise indicated, *** p < 0.001, ** p < 0.01, * p < 0.05 are shown. | PMC10179638 | ijms-24-08239-g006.jpg |
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