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0.503023 | 2dd8fefd965849b6a0bd9a2815d093d7 | Adverse events (Grades≥3) in total population | PMC10268338 | 12890_2023_2472_Fig8_HTML.jpg |
0.421528 | c8f7c7e7ed8547b7b3a66fc3b802080f | CONSORT diagram of patients included in analysis | PMC10268407 | 40644_2023_579_Fig1_HTML.jpg |
0.408164 | 2b2cb5af0a9d42ac95bc63a5151b1df8 | DECT axial imaging with 120kv reconstruction (A/C) and iodine maps (B/D) obtained at 90kv and 150kv –soft tissue mass, posterior to bladder, pre- treatment: (A) Lesion measures 2.98 cm, (B) iodine concentration − 1.4 mg/mL and post-treatment: (C) Lesion measures 3.5 cm and (D) iodine concentration − 1.1 mg/mL. Iodine maps (E/F) obtained at 150 kV- peritoneal deposit adjacent to quadrate/left lobe of liver, pre-treatment (E) iodine concentration 1.1 mg/mL, mid-treatment (F) iodine concentration 0.9 mg/mL | PMC10268407 | 40644_2023_579_Fig2_HTML.jpg |
0.465863 | 413bbe9c00a14825b86408988cf6bcf8 | Fig. 3A changes in size and iodine concentration of cancer lesion from one patient over ~ 12 months during which this patient received three different lines of treatment. RECIST and CA125 GCIG (3B) evaluations suggested stable disease throughout but the iodine concentration changes aligned more closely with the patient’s clinical condition | PMC10268407 | 40644_2023_579_Fig3_HTML.jpg |
0.398668 | 508124f53a52424aa12960cbd3486c8e | Percentage change as per RECIST/DECT-iodine concentration/CA125 criteria aligned with duration of response (months) for each relapsed patient. A) RECIST response, B) DECT- iodine concentration response, where 15% increase/reduction in concentration is designated a ‘response’ and C) GCIG CA125 response | PMC10268407 | 40644_2023_579_Fig4_HTML.jpg |
0.408236 | d9e80ec75dc0443a8c4b8da7196f94c8 | Progression Free Survival (PFS) according to response in n = 32 relapse patients. A: RECIST v1.1 median PFS 7 months (responder, n = 25) versus 5 months (non responders, n = 7) p = 0.43 HR 0.7 95% CI 0.24 to 2.05. B: DECT (iodine concentration) median PFS 7 months (responders, n = 22) versus 4 months (non responders, n = 10) p = 0.0001, HR 0.1 95% CI 0.03 to 0.33. C: GCIG CA125 Median PFS 11 months (responders, n = 17) versus 4 months (non responders, n = 15) p = 0.0028, HR 0.23 95% CI 0.09 to 0.6 | PMC10268407 | 40644_2023_579_Fig5_HTML.jpg |
0.496546 | 60889bd9cdc7401a9ce6c1386e4fe32d | Anion group in three dimensions and the novel FBB [B15O30] in LiNa11B28O48. | PMC10268625 | ao3c02248_0002.jpg |
0.482216 | 0b8d95bd07b84d85a3898753d8d03f90 | Anion group in one dimension and the novel FBB [B21O39] in Li1.45Na7.55B21O36. | PMC10268625 | ao3c02248_0003.jpg |
0.526675 | 2de766fef7994e14b4a3a869a513ecd3 | Anion group in zero dimension in Li2Na4Ca7Sr2B13O27F9. | PMC10268625 | ao3c02248_0004.jpg |
0.541482 | 5c199b996bcf4742b132b614ddf184a6 | Different [B12O24] units and their topological
representation in (a) Li3KB4O8, (b)
Cs3AlB6O12, (c) Ba4Na2Zn4(B3O6)2(B12O24), (d) Ca9B26O34(OH)24Cl4·13H2O, and (e) KB3O4(OH)2. | PMC10268625 | ao3c02248_0005.jpg |
0.373715 | 04e3dbba5e344baaa8aaf4af7bdaec74 | Calculated (black lines) and experimental
(red lines) powder XRD
patterns of LiNa11B28O48, Li1.45Na7.55B21O36, and Li2Na4Ca7Sr2B13O27F9. | PMC10268625 | ao3c02248_0006.jpg |
0.472113 | 9c4a344462574b958710650afdb387d1 | TG-DSC curves and UV–vis–NIR diffuse reflectance
spectra of LiNa11B28O48 (a, d), Li1.45Na7.55B21O36 (b, e), and
Li2Na4Ca7Sr2B13O27F9 (c, f). | PMC10268625 | ao3c02248_0007.jpg |
0.437733 | 621fe502cb004f26a905055d7f7724db | LC–MS/MS molecular
networking of the EtOAc extract of C. viridis. (A)
Molecular networking with the clusters correlating
to dolabellane-type diterpenoids. (B) Daughter ion at m/z 165 filtering criterion for a subcluster of the molecular network.
Orange spots: annotated dolabellanes. | PMC10268628 | ao3c02429_0002.jpg |
0.441887 | 35280ddc260e48f99ac478f3a6db3ad1 | Key NOE correlations of 1–5 and 8–9. | PMC10268628 | ao3c02429_0003.jpg |
0.569035 | 3c6eb1d89a93470ba7fd0dd6ae5c337a | ORTEP
views of the crystal structures of 1–2, 4–5, and 11. | PMC10268628 | ao3c02429_0004.jpg |
0.551991 | 7b26282832cb4e49927eb0b7479a34f3 | Experimental and calculated ECD data of 3, 5–6, 8–9, and 12. | PMC10268628 | ao3c02429_0005.jpg |
0.460155 | 59c8546fc2244394a3150b54119afadd | The ΔδR-S values
of the MPA esters
of 9. | PMC10268628 | ao3c02429_0006.jpg |
0.486177 | a73d3b5528ae4823860c4509b371ba00 | Conversion of Clavinflol B to 13via Clavinflol C | PMC10268628 | ao3c02429_0007.jpg |
0.40858 | 26df3d4ccb8a4903bccc9da2cc9821c2 | Biogenetic Relationships of 1–12 | PMC10268628 | ao3c02429_0008.jpg |
0.43253 | 1161ebaa2ac544659d09f5688c086c5e | Enrollment, randomization, and outcomes. | PMC10269456 | spectrum.00268-23-f001.jpg |
0.423486 | abb9e5bc917d4ed0b8ecfc7684cdd0c8 | Classification and regression tree analysis for predicting bacteria identification with the BioFire FilmArray gastrointestinal panel. The analysis identified baseline duration of bloody diarrhea (≤38 h) and the number of diarrhea episodes in any given 24-h period (≤5 or >9 episodes) as prediction of testing positive for bacteria target. Testing positive for bacteria was not observed in study participants without these clinical findings. | PMC10269456 | spectrum.00268-23-f002.jpg |
0.421881 | d3a5908745d843499f3580768f0be7c0 | Tree of Life of identified nonbacterial families assigned across all samples. | PMC10269893 | spectrum.00481-23-f001.jpg |
0.48805 | 9049f74637474e5bb0eca1f18a6ace3a | Wastewater virome. (a) Relative abundance of viral families. (b) Viral alpha diversity. Asterisks indicate Wilcoxon signed-rank test significance values. *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001; ns, not significant. | PMC10269893 | spectrum.00481-23-f002.jpg |
0.451016 | 56e15cd4c56a4497ad14b64d99d7e28e | Wastewater archaea. (a) Relative abundance of archaeal families. (b) Relative abundance of archaeal genera. (c) Archaeal alpha diversity. Asterisks indicate Wilcoxon signed-rank test significance values. *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001; ns, not significant. | PMC10269893 | spectrum.00481-23-f003.jpg |
0.457493 | f56af07a1fe14a5e8d2aa0080e9d57c2 | Wastewater protozoa. (a) Relative abundance of protozoan families. (b) Relative abundance of protozoan genera. (c) Protozoan alpha diversity. Asterisks indicate Wilcoxon signed-rank test significance values. *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001; ns, not significant. | PMC10269893 | spectrum.00481-23-f004.jpg |
0.420593 | d1462a1fb3bb4324843aaa5e372d2180 | Wastewater fungi. (a) Relative abundance of fungal families. (b) Relative abundance of fungal genera. (c) Fungal alpha diversity. Asterisks indicate Wilcoxon signed-rank test significance values. *, P ≤ 0.05; **, P ≤ 0.01; ***, P ≤ 0.001; ****, P ≤ 0.0001; ns, not significant. | PMC10269893 | spectrum.00481-23-f005.jpg |
0.443836 | 838fdd5bface4edc963424565cf047ff | Monoamine neurotransmitters and dopamine metabolites.Tissue levels of noradrenaline (a, b), serotonin (c, d), dopamine (e, f), and its metabolites 3,4-dihydroxyphenylacetic acid (g, h) and homovanillic acid (i, j) in caudate (left panels) and putamen (right panels) of control and ILBD subjects. Data are given as single values, means and the error bar s.e.m. in µg/g wet weight. *p < 0.05 vs. control by two-way analysis of variance for the factors disease (ILBD or control) and region (caudate or putamen). | PMC10272141 | 41531_2023_514_Fig1_HTML.jpg |
0.43227 | 9eebd85995d84a7f9220c8917bca4389 | ATP-dependence of vesicular uptake.Dopamine uptake by synaptic vesicles prepared from striatal tissue of control (left panels) and ILBD subjects (right panels). Total uptake (closed symbols) and uptake in the presence of reserpine (open symbols) in the putamen (a, b) and in the caudate (c, d) and comparison of total uptake in control (e) and ILBD subjects (f) of the putamen (closed symbols) vs. caudate (open symbols). Synaptic vesicle preparations were incubated with 0.1 µM [3H]dopamine and MgATP at the concentrations indicated at 30 °C for 5 min in the absence or presence of 1 µM reserpine. Data are given as means ± s.e.m. (controls, n = 6; ILBD, n = 4) and additionally single values in (e, f). *p < 0.05 vs. caudate by two-way repeated measures ANOVA for the factors region (caudate or putamen) and ATP (0, 0.1, 0.4, or 2 mM). | PMC10272141 | 41531_2023_514_Fig2_HTML.jpg |
0.432785 | c917dfb7005d4a39a3c6789c120e0c4c | Both E. coli (Gram-negative) and S. aureus (Gram-positive) show the capacity to form phenotypically plastic elongated macroscopic cell clusters. | PMC10272148 | 41467_2023_39320_Fig1_HTML.jpg |
0.458142 | 123ed7c4aa6746a891c1cd23a584857e | Experimental evolution of macroscopic multicellularity.a A schematic of our experimental evolution workflow. b Clonal phenotypes at the end of experimental evolution after growth under static conditions. Also see Supplementary movies 1 & 3 (for Anc), 5 & 7 (for the S clones), and 6 & 8 (for the R clones). In R1-R5, the habitual salinity tubes were externally perturbed at the end of the growth cycle to disrupt mats formed at the air-liquid interface and show cell clustering (see Supplementary Fig. S4 for the unperturbed tubes). | PMC10272148 | 41467_2023_39320_Fig2_HTML.jpg |
0.36932 | bf44e76c7eb44a58b4943736329eb8fb | The evolution of phenotypic plasticity in cellular morphology.The arrows point towards the qualitative direction of phenotypic plasticity. The lower and upper box hinges show the 25 and 75% quantiles, respectively; the thick horizontal band represents the median. The lower whisker denotes the smallest observation ≥ lower hinge − 1.5 × interquartile range; the upper whisker represents the largest observation ≤ upper hinge + 1.5 × interquartile range. Two-tailed t-tests (unequal variance across types): *P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; ****P ≤ 0.0001. See Supplementary Table S1 for statistical details (exact P values). The reversal of the ancestral cell perimeter plasticity (observed in eight out of 10 evolved clones) corresponded to the genetic assimilation of phenotypically plastic cell clustering (compare with Fig. 2b). All the plotted data are provided in the Source Data file. Also see Supplementary Fig. S6 for cell shape plasticity quantified in terms of cellular circularity. | PMC10272148 | 41467_2023_39320_Fig3_HTML.jpg |
0.410993 | f6f44d8c53604982a6e956e1f9f72b49 | The genetic basis of assimilated multicellularity.a Experimental evolution of genetically assimilated multicellularity primarily enriched mutations in genes involved in cell wall assembly. The schematic shows the proteins encoded by the mutated genes in red. The numbers accompanying the mutated proteins represent the number of clones that showed a mutation in a particular protein. Two genes (murF and mppA) showed synonymous mutations. b The location of mutations on the 3D structure of MraY, the protein that mutated in 70% of the sequenced clones. All the mutated regions are located near the periplasmic region of the transmembrane protein. | PMC10272148 | 41467_2023_39320_Fig4_HTML.jpg |
0.373021 | 1e5cc5343ac441c29f699a518cac06e0 | CONSORT diagram showing the flow of participants through pilot clinical trial. | PMC10272374 | fpain-04-1183954-g001.jpg |
0.422582 | 7826c23b9d9a47718ed33be1d3d34672 | Patient diary average weekly pre-exercise pain levels. | PMC10272374 | fpain-04-1183954-g002.jpg |
0.443596 | 93f02b1b9a21491e9f8d7225ef11f31d | Two main methods for generation of liver organoids. (A) Establishment of liver organoids from adult liver tissues. Healthy liver cells or liver cancer cells can be obtained via surgical resection and biopsy. Upon seeded into Matrigel with different culture components, cells assemble themselves into organoids. Liver tumoroids can be induced from liver organoids by overexpression of c-myc. (B) Establishment of liver organoids from stem cells. Both of ESCs and iPSCs can be utilized to generate liver organoids through three major steps, endodermal differentiation, hepatic specification and hepatic maturation & liver organoid formation. Each step contains several key factors. EGF, epidermal growth factor; FGF, fibroblast growth factor; HGF, hepatocyte growth factor; TGFβ, transforming growth factor beta; BMP, bone morphogenetic protein; FBS, fetal bovine serum. | PMC10272526 | fimmu-14-1180184-g001.jpg |
0.453842 | 669f08208cde4875abf74846c6ed9fa8 | Application of liver organoids in precision medicine. (A) Patient-derived organoids from tumor biopsies reveal cell origin of PLC and recapitulate the histological and genetic features of original tumors. (B) PDOs show great potential in drug screening, omics profiling and personalized treatment. | PMC10272526 | fimmu-14-1180184-g002.jpg |
0.413305 | a07e89fc91954828b06df0c70b0d1124 | Establishment of tumor microenvironment (TME) of PLC. TME of PLC is made up of complex components, including extracellular matrix, cellular components like vascular endothelial cells, immune cells, CAFs, and etc. The diagram illustrates components in TME of PLC and steps for in vitro model construction. CAF, cancer associated fibroblast; EGM, Endothelial Cell Growth Medium; HCM, Hepatocyte culture medium; HGF, hepatocyte growth factor; EGF, epidermal growth factor; FGF, fibroblast growth factor. | PMC10272526 | fimmu-14-1180184-g003.jpg |
0.483677 | ba26a01219334c8f84c0ee68b5ae9e16 | Subject flow diagram. LOS: length of stay | PMC10273541 | 12883_2023_3279_Fig1_HTML.jpg |
0.421783 | 610ae87ba8e84144a8d79f557c82b361 | Logistic regression equation | PMC10273541 | 12883_2023_3279_Fig2_HTML.jpg |
0.459242 | e823e44ed9b14bb6b8ee77384f5ee327 | Receiver Operating Characteristics (ROC) curve with sensitivity and specificity of scoring | PMC10273541 | 12883_2023_3279_Fig3_HTML.jpg |
0.39145 | d441c30c2a2945588c48422aa6188cf5 | Probability of prolonged length of stay for each total score | PMC10273541 | 12883_2023_3279_Fig4_HTML.jpg |
0.486358 | 4317a4a531754c41bcfc2d01a375ef8c | Flow diagram of database search results and screening strategy of the articles reviewed in the systematic review. | PMC10273880 | iaa-0184-0567-g01.jpg |
0.424223 | ac71af6d07c543ad8e3983a708051126 | Most frequently reported food triggers in children. A systematic review of the most frequently reported food triggers in cohorts of children diagnosed with FPIES was conducted. CM was the most reported food trigger, while the prevalence of the remaining triggers varied by country/region. | PMC10273880 | iaa-0184-0567-g02.jpg |
0.451164 | 0aa041890afa4630b79f164bd54f150b | Ages of trigger onset and resolution by food trigger. The median ages of patients reported by each study (each represented by a black circle) at FPIES onset (gray) and resolution (white) showed trends by food trigger. | PMC10273880 | iaa-0184-0567-g03.jpg |
0.439372 | d22dd22611e449df8e3e6f464fbbffbb | A contrast examination shows that the tracheoesophageal fistula (arrowhead) and the upper end of the esophageal pouch (arrow) are at the second thoracic vertebrae (Th2). The contrast was injected through a nasogastric tube. | PMC10274229 | amjcaserep-24-e938723-g001.jpg |
0.408352 | 4102df0c77504d5eb0301f72a5af99fc | A contrast examination shows that the tracheoesophageal fistula (arrowhead) and the upper end of the esophageal pouch (arrow) are at the first to second thoracic vertebrae (Th1-2). The contrast was injected through a nasogastric tube. | PMC10274229 | amjcaserep-24-e938723-g002.jpg |
0.469575 | 7d3790132320494190196e026ab5434e | Gating strategy.Representative gating strategy for isolating SIV Env gp130-binding memory B cells (single live CD3−, CD14−, CD16−, CD20+, CD27+, IgM−, SIV Env gp130+ cells) from a RM chronically infected with SIVmac239. | PMC10274751 | nihpp-2023.06.02.543510v1-f0001.jpg |
0.435384 | 296548d8e47d4db1be0f4674cf183a96 | Workflow for cloning antibodies from single cells using cDNA synthesized by 5’RACE.Full-1 ength cDNA is synthesized from the mRNA of individual B cells using an MMLV-based reverse transcriptase (RT) and primers containing synthetic primer binding sites. cDNA synthesis is initiated by the poly(dt) RT oligo, and the RT adds non-templated deoxycytidines (CCC) to the 3’ end of the cDNAs. The tem plate-switching oligo (TSOUoUi) then binds to the CCC overhang, and the RT completes cDNA synthesis using TSOUoUi as the tem plate. The resulting cDNAs contain tw o universal primer binding sites at the 5’ end (5U0 and 5Ui) and one at the 3’ end (3U). A pream plification step with the 5U0 and 3U primers is included to increase the amount of tem plates available for subsequent steps. The first round of PCRs are performed with the universal outer forward primer (5U0) and a reverse primer (31g0) specific for the IgH, IgK, or IgL chain. The second round PCR is performed with the universal inner forward primer (5Ui) and a nested reverse primer (31gi) specific for the IgH, IgK, or IgL chain. The result is a PCR product containing the 5’ end of the Ig tem plates. These products are sequenced to select gene-specific primers that contain restriction sites to amplify the IgV genes and clone them into expression vectors. | PMC10274751 | nihpp-2023.06.02.543510v1-f0002.jpg |
0.478061 | ba3ebf8ad637425b8f83160369a439b2 | Binding of mAbs to SIV Env gp130.Anti-SIV Env gp130 ELISA titration curves for supernatants from HEK293F cells transfected with plasmids encoding 10 recombinant mAbs. mAbs showing optical density (OD) 450 above 1 at a 1:160 dilution are highlighted in red. A mAb binding an irrelevant epitope was used as a negative control (green). | PMC10274751 | nihpp-2023.06.02.543510v1-f0003.jpg |
0.429924 | 75a40e35ec0943149699625af7c2eaf8 | Choropleth maps of reduced visual acuity prevalence in Mainland China by province. The Global Moran's I index represents the spatial autocorrelation and distribution pattern of the global incidence. The z score and P value are both measures of statistical significance and are used to determine whether to reject the null hypothesis on a factor-by-element basis. If Moran's I index is greater than 0, and P < 0.05, z > 1.96, then it indicates that the study area has spatial correlation and its distribution is clustered.26 In this study, the result of spatial autocorrelation analysis of reduced visual acuity prevalence in Mainland China is the following: Moran's I = 0.29, P < 0.001, z score = 4.22; distribution is clustered. | PMC10275385 | iovs-64-7-23-f001.jpg |
0.4399 | ac3611dbaef1491db646be6cf3d9434d | The relationships between prevalence of reduced visual acuity and area-level socioeconomic and environmental measures. We equally divided the records into three subgroups in each panel according to the value of the factor from the minimum to the maximum. The black dot represents the means of the corresponding factor and the reduced VA prevalence of each subgroup, and the solid black line represents the standard deviation of the reduced VA prevalence. The black dotted line is the fitting result of the smooth curve. | PMC10275385 | iovs-64-7-23-f002.jpg |
0.435087 | a8314c0c4ff847e9a6a512f922e6ee81 | Map showing the location of the five bioreactor facilities | PMC10275798 | 10661_2023_11358_Fig1_HTML.jpg |
0.452964 | c4c55d34ee3d4ac98f76138fe1f5fc12 | Top: total nitrogen (TN) load per day at the inlet of the bioreactors relative to hydraulic load per day. Middle: TN removal (total removal per day) relative to hydraulic load per day. Bottom: TN removal (percent removal per day) relative to hydraulic load per day. The relationships between the variables were assessed using linear regressions before and after transformation of the hydraulic load using natural logarithms. Legends GA, GB, and GC are Gyldenholm A, B, and C, respectively. HA, HB, and HC are Hofmansgave A, B, and C, respectively. Se is Serupgård. Eg is Egsmarken. Du is Dundelum | PMC10275798 | 10661_2023_11358_Fig2_HTML.jpg |
0.429862 | 996fceea0bc24a598f44ca176feb1cbb | Total P release (black line) and hydraulic load (blue line) from the bioreactor at Serupgård during the two hydrological years 2018–2019 and 2019–2020 | PMC10275798 | 10661_2023_11358_Fig3_HTML.jpg |
0.429825 | dc4b64d248c04a4c91f54c0697e09793 | Investments in woodchip bioreactors depending on reactor size. Investments in biomaterial over time are included for all projects. Minimum standard costs exclude investment in pumps, but this is included in the maximum standard costs, standard cost min | PMC10275798 | 10661_2023_11358_Fig4_HTML.jpg |
0.49682 | fac8392bb28c4b3ea00066580be6b18c | VR1 forms functional channels in Xenopus oocytes. (A) Current family activated by a saturating capsaicin concentration (4 μM) in an outside-out patch obtained from stepping the voltage from a holding potential of 0 mV to between -100 and +100 mV. For scale bar see (C). (B) Current-voltage relation for currents activated by 4 μM capsaicin. Data were normalized to the value of the current at -100 mV. (C) Current family activated by a sub-saturating capsaicin concentration (0.5 μM). (D) Current-voltage relation for currents activated by 0.5 μM capsaicin (red) with data from currents obtained with 4 μM capsaicin shown also (blue). Data were normalized to the value of the current at -100 mV. (E) Dose-response relation for activation by capsaicin plotted on a double-log scale. The smooth curves are fits with the Hill equation with K½ = 440 nM, Imax = 567 pA, and n = 2.2. Filled circles represent actual data values. All data in this figure are from the same patch. | PMC102763 | 1471-2202-3-4-1.jpg |
0.466602 | 20544d8b85da48b4a90353a729b2af2b | VR1 is glycosylated at N604. (A) Cartoon (not to scale) of proposed subunit topology for a single VR1 subunit. Shown are the epitopes for the N-terminal and FLAG antibodies used in Western blot experiments, and the consensus sequence for glycosylation, located just distal to the fifth transmembrane domain at position 604. The red circle depicts the approximate localization of this consensus sequence. The line parting from the circle points to the sequence of this N-glycosylation site and the yellow box shows the asparagine which was substituted for a serine in order to produce the glycosylation mutant (N604S). (B) Western blot of oocytes expressing VR1 probed with the N-terminal antibody. Uninjected oocytes and oocytes expressing VR1 were prepared as described in Experimental Procedures. The monomer was observed as a doublet at 80 kDa and at 84 kDa in VR1-injected oocytes and a third band of 200 kDa was also observed in these oocytes. No bands were observed in the uninjected oocytes. (C) Western blot of oocytes expressing VR1 probed with the FLAG antibody. Bands are as in (B). (D) Western blot of oocytes expressing VR1 or N604S. Uninjected oocytes and oocytes expressing VR1 or N604S were prepared as described in Experimental Procedures. The monomer doublet in the VR1 is not present in the N604S mutant; only the 80 kDa band is observed. No bands were observed in the uninjected oocytes. This blot was probed with the FLAG antibody. | PMC102763 | 1471-2202-3-4-2.jpg |
0.447998 | e447fc9a36eb451e9b08e644127f02bd | N604S forms functional channels, with properties like that of wild type. (A) Current family activated by a saturating capsaicin concentration (4 μM) in an outside-out patch obtained from stepping the voltage from a holding potential of 0 mV to between -100 and +100 mV. (B) Current-voltage relation for currents activated by 4 μM capsaicin for N604S (blue) and wild-type VR1 channels (green). Data were normalized to the value of the current at-100 mV. (C) Current family activated by a sub-saturating capsaicin concentration (0.5 μM). (D) Current-voltage relation for currents activated by 0.5 μM capsaicin for N604S (red) and wild-type VR1 (green) channels. Data were normalized to the value of the current at -100 mV. (E) Dose-response relations for activation by capsaicin plotted on a double-log scale. The smooth curves are fits with the Hill equation with K½ = 905 nM, Imax = 114 pA, and n = 1.8. Filled circles represent actual data values, plotted on a double-log axis. All data in this figure is from the same patch. | PMC102763 | 1471-2202-3-4-3.jpg |
0.492648 | f07ce0ca131141e5860605f691aee3a6 | The 200 kDa band represents a dimer of VR1 subunits. Western blot of oocytes expressing wild-type VR1, Δ2–52, or wild-type VR1 + Δ2–52. Oocytes were prepared as described in Experimental Procedures. The band observed for VR1-express ing oocytes was at 200 kDa, the band observed for the Δ2–52-expressing oocytes was at 180 kDa, while oocytes injected with a 1:1 ratio of VR1 and Δ2–52 RNA yield three bands of 200 kDa, 180 kDa, and 190 kDa. This blot was probed with the FLAG antibody. | PMC102763 | 1471-2202-3-4-4.jpg |
0.496481 | b85a8d06ac524f388796dc4266f5bfde | Δ2–52 forms functional, capsaicin-activated channels. (A) Current family activated by a saturating capsaicin concentration (4 μM) in an outside-out patch obtained from stepping the voltage from a holding potential of 0 mV to between -100 and +100 mV. (B) Current-voltage relation for currents activated by 4 μM capsaicin for Δ2–52 (blue) and wild-type VR1 (green) channels. Data were normalized to the value of the current at -100 mV. (C) Current family activated by a sub-saturating capsaicin concentration (0.5 μM). (D) Current-voltage relation for currents activated by 0.5 μM capsaicin for Δ2–52 (blue) and wild-type VR1 (green) channels. Data were normalized to the value of the current at -100 mV. (E) Dose-response relations for activation by capsaicin plotted on a double-log scale. The smooth curves are fits with the Hill equation with K½= 390 nM, Imax = 1630 pA, and n = 1.5. Filled circles represent actual data values. All data in this figure are from the same patch. | PMC102763 | 1471-2202-3-4-5.jpg |
0.418284 | f83086c21a884e58b0dfea67b73ea884 | VR1 dimerization is not affected by reducing agents, capsaicin, Ca2+ or transglutaminase inhibitors. (A) Western Blot of the effect of reducing agents on the VR1 dimer. The addition of DTT (100 mM) and TCEP (20 mM) did not modify the ratio of monomer to dimer in VR1-expressing oocytes (p > 0.05, for 3 independent experiments). (B) Effect of Ca2+ on dimer formation in VR1. The addition of Ca2+ to the biochemical assays (in the presence or the absence of capsaicin, lanes 1 and 2) did not modify the ratio of monomer to dimer (p > 0.05, for 3 independent experiment). Addition of EGTA (2 mM) to the assays (lanes 3 and 4) did not modify the monomer to dimer ratio either (p > 0.05, for 3 independent experiments). For the Ca2+-free condition, the expected free Ca2+ concentration was 0.4 nM, calculated using WebMax C version 2.1 . and assuming a contaminant level of 5 μM Ca2+ in our water. For the condition in which Ca2+ was present, we added 1.8 mM Ca2+ and no chelator to the solution (see Materials and Methods). (C) Effects of transglutaminase inhibitors on dimerization of VR1. The addition of cysteamine (20 mM) and MDC (250 μM) to oocytes did not alter the amount of dimer in relation to monomer when compared to the control lane which did not receive any treatment (p > 0.05, for 3 independent experiments). | PMC102763 | 1471-2202-3-4-6.jpg |
0.473009 | e09735b4251b4930a5e6c6cd6c7602e9 | The inflammatory and immune molecular mechanism in dry eye disease | PMC10276682 | IJO-71-1248-g001.jpg |
0.421929 | 8d5bcdc70e7b41e294420de9651f616f | Nasopharyngeal carriage rates of S. aureus, pneumococcus and co-carriage from 2014 to 2018 in children less than 2 years of age, n = 3140. | PMC10276771 | gr1.jpg |
0.414017 | 80e3993c3f974a359b42faccd1ae3d17 | Nasopharyngeal carriage rates of S. aureus, pneumococcus and co-carriage according to the number of PCV10 doses received by the children less than 2 years of age, n = 3140. | PMC10276771 | gr2.jpg |
0.406613 | 589cb166090d45f5882bcb3fd2dad1fd | Proportion of S. aureus positive isolates which were non-susceptible to various antimicrobial agents (n = 176). | PMC10276771 | gr3.jpg |
0.452804 | b79e36ce88584271aba5f1d1a92e5091 | (A) Preoperative Zanca view. A line was drawn between the most cranial point of each coracoid (white line). The coracoclavicular (CC) distance between each coracoid and clavicle was measured perpendicular to the line between the two coracoids (blue lines). (B) Postoperative Zanca view. A line was drawn between the most cranial point of each coracoid (white line). The CC distance between each coracoid and the clavicle was measured perpendicular to the line between the two coracoids (blue lines). Pre-A: preoperative CC distance on the affected side, Pre-U: preoperative CC distance on the unaffected side, Post-A: postoperative CC distance on the affected side, Post-U: postoperative CC distance on the unaffected side. | PMC10277717 | cise-2022-01298f1.jpg |
0.428852 | a8b128a609d3468b8b70cc2c146b62ed |
Demographics, laboratory and treatment characteristics of the studied patients. A: This study included 96 (51.9%) females and 89 (48.1%) males; B: The majority were rural residents (64.9%, n = 120), while 35.1% (n = 65) were urban residents; C: The majority were of low socioeconomic status (51.9%, n = 96), while 31.4% (n = 58) and 16.8% (n = 31) were of middle and high socioeconomic states, respectively; D: Investigations done by patients included serology and complete blood count (70.3%, n = 130, polymerase chain reaction (23.2%) and computed tomography-chest (17.3%, n = 32). While 39.5% (n = 73) did not do any investigations. E: The received pharmacotherapies and interventions to treat chemosensory disorders included local steroids (47.6%, n = 88), vitamins and supplements (46.5%, n = 86), olfactory training (22.7%, n = 42) and systemic steroids (12.4%, n = 23), while 22.7% of the patients (n = 42) did not receive any therapy. PCR: Polymerase chain reaction; CBC: Complete blood count; CT: Computed tomography. | PMC10278074 | WJCP-12-133-g001.jpg |
0.396411 | d2ad0dc7b5d74c6ca37c69aed434a46b |
General, systemic and ear, nose and throat manifestations of viral infection of the studied patients. ENT: Ear, nose and throat. | PMC10278074 | WJCP-12-133-g002.jpg |
0.45801 | 81daf583f0be4c9b8d01d924b4489f6c |
Manifestations of smell, taste, flavor and trigeminal sensory disorders of the studied patients.
| PMC10278074 | WJCP-12-133-g003.jpg |
0.346636 | a18dec876c5c44adbc850171ffb9bf9b |
Types of parosmia and dysgeusia/distortion of flavor in the studied patients.
| PMC10278074 | WJCP-12-133-g004.jpg |
0.473977 | ab1332f58ab041f2bf7f26e096c613e5 | The application of decellularized vascular matrix in tissue engineering. Created with BioRender.com | PMC10278309 | 12938_2023_1120_Fig1_HTML.jpg |
0.457724 | 6c271e53d2714080a2c9ccf072fcd1b1 | The combination of multiple decellularization methods used in the study of Ilanlou. Created with BioRender.com | PMC10278309 | 12938_2023_1120_Fig2_HTML.jpg |
0.376881 | d3b3fe95237f40e0b80c2178007ca57c | The HR of composite cardiac events across the races (Asian, white and black). CI: Confidence interval; HF: Heart failure; HR: Hazard ratio; SE: Standard error; SGLT-2: Sodium-glucose cotransporter 2. | PMC10278744 | cm9-136-1004-g001.jpg |
0.412593 | 1d8f89097bf245638d96cf5218abfc01 | Number of suicides per day and the relative rate of each search term volume by period. Cnt_Dth: number of suicides per week. Relative rate: relative rate of each search volume from Naver Datalab. | PMC10279855 | fpsyt-14-1186754-g001.jpg |
0.370613 | 7828a130218948e2a13a54f41dc4317a | Distribution of daily number of suicides. The horizontal axis represents the number of suicide events per day and the vertical axis represents the number of days during the analysis period (1,095 days) with the corresponding number of suicides. For example, in adolescent men that are depicted with the red bar, 993 on the vertical axis indicates that for 933 days during the study period, zero suicides were documented. | PMC10279855 | fpsyt-14-1186754-g002.jpg |
0.399969 | 1ccbbfa4e2634944be983b1366ac2ba6 | The framework of the smart agriculture. | PMC10280676 | peerj-cs-09-1304-g001.jpg |
0.49853 | a0a8970ff7eb453db27f32b95452ed0e | The construction of the LSTM cell. | PMC10280676 | peerj-cs-09-1304-g002.jpg |
0.467148 | c55ea92b7d4c453aaef0147f54a51e4b | The framework for the PSO-LSTM model. | PMC10280676 | peerj-cs-09-1304-g003.jpg |
0.446518 | 1e25737dd06f4ae6916cf36ae7268e06 | Result of PSO-LSTM. | PMC10280676 | peerj-cs-09-1304-g004.jpg |
0.47172 | fc61ac615e3a43e6a4f4cc5da962b895 | Relative error of the prediction. | PMC10280676 | peerj-cs-09-1304-g005.jpg |
0.484817 | 3ac236e7f08649eb8e60fb37dabd2d95 | Result of different methods among different years. | PMC10280676 | peerj-cs-09-1304-g006.jpg |
0.476804 | d89800cf8cce4e97ad0b487ddc03b2cf | Result of the current production prediction using historical data. | PMC10280676 | peerj-cs-09-1304-g007.jpg |
0.419786 | 8c9e7757d0774922b5900ee7e645efac | Two types of surface defects of industrial products.Images taken from Bergmann et al. (2020a) (License: CC-BY-NC-SA 4.0). | PMC10280690 | peerj-cs-09-1264-g001.jpg |
0.496802 | f6027e2084db492caa5bfb053d267b11 | MeDetection model.SN stands for Siamese network, which is applied to calculate the difference features. F stands for the feature difference extraction module. The 4conv network is set as the main feature extraction backbone, while MAML based training strategy is applied to optimize the detection model. The CA module embedded in the feature extraction backbone further strengthens the defect features from the perspective of coordinate attention. Images taken from Bergmann et al. (2020a) (License: CC-BY-NC-SA 4.0). | PMC10280690 | peerj-cs-09-1264-g002.jpg |
0.53551 | 5887e6834a8049eca2ebe9f7f6ecd8fc | Visualization of “screw” dataset, where the samples are placed randomly.Images taken from Bergmann et al. (2020a) (License: CC-BY-NC-SA 4.0). | PMC10280690 | peerj-cs-09-1264-g003.jpg |
0.42604 | 2beed12aa8e24f56b9ad911f3ed9d5a7 | The relationship between recall rate and model training epochs.The blue line with triangle symbols shows the recall curve of each epoch when the model is fine-tuned with the initialized weights obtained from MAML training, while the yellow line with circle symbols shows the results for the model trained with random initialization weights. | PMC10280690 | peerj-cs-09-1264-g004.jpg |
0.3932 | 9678ea71e3284f969036bfdd04018bf1 | Visualization of defect location.The first row shows the original sample images with defects. The second and third rows show the localization results of the defects caused by the MAML-based training strategy and the random weight training strategy, respectively. Images taken from Bergmann et al. (2020a) (License: CC-BY-NC-SA 4.0). | PMC10280690 | peerj-cs-09-1264-g005.jpg |
0.413567 | 071746099f4849638291f89a4dcef084 | Diagrama de flujo de las fases del estudio y evolución de la muestra. GC: grupo control activo: grupo de acompañamiento con seguimiento activo de 12 meses postintervención; GI: grupo de intervención psicoterapéutica sin seguimiento activo de 12 meses postintervención; GIS: grupo de intervención psicoterapéutica con seguimiento activo de 12 meses postintervención. | PMC10280724 | RN-75-203-g001.jpg |
0.46033 | 41f25b8ea8204487b2fb2141101fd3cf | Estructura, objetivos y actividades de las sesiones de la intervención psicoterapéutica. Las 16 sesiones del programa de intervención psicoterapéutica basal tienen una periodicidad semanal, mientras que las 11 de seguimiento son mensuales. | PMC10280724 | RN-75-203-g002.jpg |
0.419489 | 2329d9a53bf24aababaf88601ef4fe3b | ERBB2 overexpression reduces senescence by decreases the level of PTGS2 in NP cells. (A-B) Representative western blots and quantification of PTGS2 in the control, vector and PTGS2 groups. (C-D) Representative western blots and quantification of PTGS2, P16, and P21 in the vector, ERBB2 and ERBB2 + PTGS2 groups. (E-F) Representative immunofluorescence and quantification of PTGS2 and P16 in NP cells treated as above. (G) Representative SA-β-gal staining and quantification of SA-β-gal activity in the NP cells; blue, senescent NP cells. Quantitative measurements represent means ± SD (n = 3 biological replicates). Significant differences between the groups: ***P < 0.001 | PMC10280935 | 12891_2023_6625_Fig10_HTML.jpg |
0.430111 | ba6512a2a2ca4385a788ebc151cc4226 | Flowchart of the present research | PMC10280935 | 12891_2023_6625_Fig2_HTML.jpg |
0.467499 | 72374bbaacc4442f96a80ccea86a3e55 | Identification of DEGs and correlation analysis. (A) Boxplots of sample expression levels after normalization of the GSE41883 dataset. (B) Principal component analysis (PCA) after normalization of the GSE41883 dataset. (C) UMAP analysis of GSE41883 dataset normalization. (D) Volcano plot of DEGs. Red indicates upregulation, blue indicates downregulation, and gray is used to represent the remainder. (E) Heat map of high- and low-expression top 20 DEGs. Red and blue represent upregulated and downregulated genes, respectively. (F) Bitmap of Pearson correlation analysis of the top 10 upregulated and downregulated DEGs. Red and blue represent positive and negative correlation, respectively | PMC10280935 | 12891_2023_6625_Fig3_HTML.jpg |
0.489002 | 175654b47642479aad0ba0bcf70ea317 | Screening of SR-DEGs. (A) Venn diagram showing 30 SR-DEGs selected by intersection of the senescence-related gene list and DEGs in the HAGR database. (B) Volcano plot of SR-DEGs in the control and TNF-α treated groups. (C) Heat map of 30 high- and low-expression SR-DEGs. Red and blue represent upregulated and downregulated genes, respectively | PMC10280935 | 12891_2023_6625_Fig4_HTML.jpg |
0.445055 | 751ebf13c4a84f54aaa4f9307cc28d54 | Functional enrichment and pathway analysis of SR-DEGs. (A) GO enrichment analysis of SR-DEGs. (B–D) Circle graph showing the SR-DEGs enriched in the different GO categories (BP, CC, and MF). The blue points represent the GO category, and the size of a point indicates the number of the genes it includes. (E) KEGG pathway enrichment analysis of DEGs. (F) Circle graph showing the number of SR-DEGs enriched in KEGG pathway analysis | PMC10280935 | 12891_2023_6625_Fig5_HTML.jpg |
0.476506 | b3f45084fb5b4a3394f71d0d1f4fb356 | PPI network and module analysis. (A) The STRING database was used to construct a PPI network of SR-DEGs with 30 nodes and 100 edges. (B) Module 1 contained 13 gene nodes and 50 edges. MCODE score = 8.33. (C) Four algorithms (Degree, MNC, DMNC, and MCC) were used to obtain the top 10 genes as hub SR-DEGs. (D) Venn diagram showing the intersection of hub SR-DEGs obtained by four algorithms; ERBB2 and PTGS2 were finally obtained as hub SR-DEGs. (E) Analysis of two hub SR-DEG expression levels in two groups. (F) STRING database was used to construct the PPI network of two hub SR-DEGs. | PMC10280935 | 12891_2023_6625_Fig6_HTML.jpg |
0.403882 | 68b96876e92f4433b62e42a0d2ba1aa9 | TF–gene interaction, TF–miRNA coregulatory networks, and Candidate drugs. (A) TF–gene interaction network with hub SR-DEGs. (B) TF–miRNA coregulatory network with hub SR-DEGs. (C) Candidate drugs for hub SR-DEGs from the DSigDB database | PMC10280935 | 12891_2023_6625_Fig7_HTML.jpg |
0.383435 | 33c5757673df43bd889a3b185146e496 | Identification of human NP cells in culture and the expression of PTGS2 and ERBB2 in senescent NP cells. (A) Identification of human NP cells. (Morphology of nucleus pulposus cells is mostly long fusiform, irregular or star shaped; The proteoglycans (PGs) released in the culture medium was measured using Alcian blue stain; collagen II and aggrecan fluorescence were detected). (B) SA-β-Gal staining assay of human NP cells. (C) qPCR showed that the PTGS2 and ERBB2 mRNA level in the treatment with or without TNF-α(20ng/ml,48 h). (D) Western blots and quantification of PTGS2, ERBB2, P16, and P21 in human NP cells after treatment with TNF-α(20ng/ml,48 h). (E) qPCR showed that the PTGS2 and ERBB2 mRNA level in the mild degenerated NP tissues (Grade II) and the severe degenerated NP tissues (Grade V). Quantitative measurements represent means ± SD (n = 3 biological replicates). Significant differences between the groups: **P < 0.01, ***P < 0.001 | PMC10280935 | 12891_2023_6625_Fig8_HTML.jpg |
0.457134 | 6c2cd58b43174745a44087ade0bbf63d | ERBB2 overexpression reduces TNF-α–induced NP cells senescence and the level of PTGS2. (A-B) Representative western blots and quantification of ERBB2 in the control, vector and ERBB2 groups. (C-D) Representative western blots and quantification of ERBB2, PTGS2, P16, and P21 in the vector, TNF-α and TNF-α + ERBB2 groups. (E-F) Representative immunofluorescence and quantification of ERBB2 (red) and P16 (green) in NP cells treated as above. (G) Representative SA-β-gal staining and quantification of SA-β-gal activity in the NP cells; blue, senescent NP cells. Quantitative measurements represent means ± SD (n = 3 biological replicates). Significant differences between the groups: **P < 0.01, ***P < 0.001 | PMC10280935 | 12891_2023_6625_Fig9_HTML.jpg |
0.430973 | 1fb4d025cc0843cdb1567657d1ac714d | BMI, body mass index; BP, blood pressure; DBP, diastolic blood pressure; ICPB, International Consortium for Blood Pressure; PP, pulse pressure; SBP, systolic blood pressure. | PMC10281555 | ehad101_ga1.jpg |
0.408323 | 05a37f04ef8e431686edbd59c0fce0f2 | Flow chart of inclusion and exclusion of studies for the systematic reviews.aFor Ovid MEDLINE, we defined the limit at age group as “Newborn infant (birth to 1 month).” CRE, carbapenem-resistant Enterobacterales; CRKP, carbapenem-resistant Klebsiella pneumoniae; KP, Klebsiella pneumoniae. | PMC10281588 | pmed.1004233.g001.jpg |
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