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0.468907 | 343547432a5c4adca550124afef8b03a | PRISMA 2020 flow chart. Flow chart of included and excluded trials. PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses. | PMC9636470 | gr1.jpg |
0.434806 | e010e0169d7a4514aafea25fb3941740 | Effect of vitamin D supplementation on total cancer incidence. | PMC9636470 | gr2.jpg |
0.502889 | a27e2b738e92447cab8c8eb4c88b71a6 | Effect of vitamin D supplementation on total cancer mortality. | PMC9636470 | gr3.jpg |
0.441607 | d0f99bee3b364396a6aec6df95a6154a | The principle of EEG envelope spectrum analysis. (A) Shows a simulated EEG signal, consisting of the sum of a 2 Hz sinusoid modulated by a 0.2 Hz carrier frequency, a 12 Hz sinusoid modulated by a 1 Hz carrier frequency, and pink noise. Overlain blue and red lines show the instantaneous amplitude or envelope (modulus of the Hilbert transform) of the delta (1–4 Hz) and sigma (10–16 Hz) frequency ranges, respectively. (B) Shows the power spectral density of the original signal (left) and the delta (middle) and sigma (right) envelopes. Note that the carrier frequencies are accurately recovered from spectral analysis of the envelopes (with some impurities due to added noise and the fact that the modulus of the Hilbert transform of a modulated signal is not fully sinusoidal). The spectrum of the envelope reveals periodic fluctuations in the amplitude of higher-frequency activities. | PMC9637727 | 41598_2022_22255_Fig1_HTML.jpg |
0.405438 | 17154a9ab21d415d857751beb53dee8f | Coupling between EEG envelope in the cortical surface and MUA within the adjacent cortex in NREM sleep. (A) Cross-correlation of the two signals. The horizontal axis indicates time lags, the vertical axis indicates IME channel (N = 23, deeper channels shown at the bottom), while the color axis indicates correlation coefficients. Black outlines show statistically significant results after FDR correction. (B) Magnitude-squared coherence between the two signals. Overlain lines represent individual IME channels. Because of the large number of channels and no substantial between-channel differences, no particular pattern in color coding was used. Dots indicate statistical significance after FDR correction on the corresponding channel. Deeper channels are shown at the top. (C) Mean MUA amplitude (in within-segment z-scores) by ECoG envelope phase bins. Dots indicate statistical significance after FDR correction on the corresponding channel. A sinusoid is overlain in the low delta subplot for illustration. On (B,C), for better visibility only IME channels are shown where at least one data point reached significance. | PMC9637727 | 41598_2022_22255_Fig2_HTML.jpg |
0.436643 | 9128cd57d1be4b9abeadf27e2015a6c3 | An illustration of EEG envelopes, the colliding window method and its results. (A) Illustrates the colliding window method. (B) Shows a single epoch of illustrative envelope and MUA data (ECoG low delta envelope and smoothed MUA from the fifth IME channel located in cortical layer III). The Pearson correlation of the two signals is shown for reference. Both the ECoG envelope and the MUA is detrended and demeaned, but not z-transformed. (C) Shows the distribution of available sleep data after artifact rejection using the colliding window method. For each participant, black lines mark the data segments used in analysis. The lower panel shows the total number of participants with available data as a function of time after recording start. Note the lack of systematic undersampling of any part of the night. (D) Illustrates the log-transformed envelope spectra. All data was z-transformed by frequency band to eliminate mean differences. The frequency axis is shown on a log scale to enhance the low frequency ranges which are of particular interest. Note spectral peaks at ~ 0.05–0.06 Hz, ~ 0.25 Hz and ~ 1 Hz, the latter most prominent in the beta range. | PMC9637727 | 41598_2022_22255_Fig3_HTML.jpg |
0.442218 | 9befcb4da09b438c878f011dfb09ff29 | The reliability of the sleep EEG envelope spectrum. (A) Shows raincloud plots55) by vigilance state and reliability type, showing raw data overlain with box plots on the left side and kernel density curves on the right side. Data from all frequency bands, envelope frequency bins and scalp channels are pooled for estimating the box plot, while individual instances are shown as data points. (B) Illustrates reliability by envelope frequency bin. Data from all frequency bands and scalp channels are pooled, shading indicates 95% confidence intervals of the mean. | PMC9637727 | 41598_2022_22255_Fig4_HTML.jpg |
0.45365 | ed3f5c47a37441f6a0a99a72f5248938 | Correlations between the NREM envelope spectrum and age, sex and general cognitive ability (IQ). Colored lines represent correlation coefficients by scalp channel. Color codes indicate scalp region, with individual channels from the same region shown with the same color. Black horizontal lines show the threshold of conventional (p = 0.05) significance. Colored dots (with color coding identical to lines) above the lines indicate a statistically significant correlation after FDR correction on the corresponding channel. | PMC9637727 | 41598_2022_22255_Fig5_HTML.jpg |
0.453681 | ab5142049a2a47758c877313d71872b3 | Correlations between the REM envelope spectrum and age, sex and general cognitive ability (IQ). Colored lines represent correlation coefficients by scalp channel. Color codes indicate scalp region, with individual channels from the same region shown with the same color. Black horizontal lines show the threshold of conventional (p = 0.05) significance. Colored dots (with color coding identical to lines) above the lines indicate a statistically significant correlation after FDR correction on the corresponding channel. | PMC9637727 | 41598_2022_22255_Fig6_HTML.jpg |
0.438221 | 345094840127446c9c14e3fbe28ad3d5 | The performance of elastic net regression models predicting age, sex and IQ from the envelope spectrum. Topographic plots illustrate the correlation between predicted and actual phenotypes in the validation sample. (Elastic net regression models were run separately for each channel). The correlation for channels on which the elastic net model did not converge is set to 0 and not counted towards the average performance described in the text. | PMC9637727 | 41598_2022_22255_Fig7_HTML.jpg |
0.397517 | 67e650b2f58747d599e1ca410c3bd1c6 | Generation of hGNE
M743T/WT transgenic lines. (A) A schematic representation of the p(-1.9gne:hGNEM743T/WT; insulin:EGFP) plasmid. Genes, promoters, LTRs, polyadenylation signal and restriction sites are indicated. (B) The hGNE transgenic lines develop normally. The figure presents brightfield images of a WT (top), hGNE
WT
transgenic (middle), and hGNE
M743T
transgenic (bottom) larvae at 8 dpf. Scale bar = 1 mm. (C) RT-PCR analysis of hGNE mRNA expression in hGNE
M743T and hGNE
WT transgenic lines. Agarose gel electrophoresis of RT-PCR amplification products of the hGNE gene (top) and eef1a1a (bottom) as the internal control. Both the hGNE
M743T (Mut) and hGNE
WT (WT) cDNA samples show the expected amplification in all tested time points and tissues. Non-transgenic WT zebrafish cDNA (WT ZF cDNA) and genomic DNA from transgenic fish (Tg DNA) served as controls for each target. (NTC) no template control, (M) Muscle, (Br) Brain tissue. | PMC9637792 | fcell-10-976111-g001.jpg |
0.427588 | 3ea91970627547008b73090033b0adb3 | Generation and development of the gne knockout zebrafish. (A) Schematic representation of CRISPR/Cas9 mutagenesis in the zebrafish gne gene, exon 3. A diagram of the gne gene containing 12 exons, represented by green (epimerase domain) and blue (kinase domain) rectangles, and the UTRs. The PAM sequence is specified, position of the generated 4 bp deletion site is indicated by scissors symbol and the putative premature termination codon is depicted by a stop symbol. (B) Sanger sequencing chromatogram of gne KO larvae (bottom sequence) indicating a 4 bp deletion in gne exon 3. The PAM sequence and the double-strand break position (scissors) are indicated. (C) Zebrafish gne alleles PCR genotyping. The top panel represents a schematic view of the primers’ position in each PCR reaction. Wild-type specific PCR is presented on the top gel, and mutant specific on the bottom gel. Green arrows represent a 399 bp amplicon of exon 3. Blue arrows represent a 300 bp wild-type (WT) specific amplicon, red arrows represent the mutant (KO) specific amplicon. Heterozygotes (HT) show both allele-specific amplicons. 100 bp DNA marker was loaded on the left lanes of each 1.5% agarose gel. (D) Zebrafish gne KO larvae exhibit a normal phenotype at 5 and 6 dpf. gne genotype and age are indicated at the bottom of each image. Scale bar = 1 mm. (E) Zebrafish gne KO phenotype. Zebrafish gne KO larvae present deflation of the swim bladder and progressive curving of the body at 7 and 8 dpf, compared to WT zebrafish at 8 dpf. Red arrows indicate the swim bladder. Scale bar = 1 mm. | PMC9637792 | fcell-10-976111-g002.jpg |
0.409491 | 086b69ac1b1b4dc2a85c15c826ad3b98 | Structural and functional characterization of the gne knockout larvae. (A) Analysis of morphologic measurements (body length, body height, eye diameter) in gne
−/−
mutants and WT larvae at 5 and 6 dpf did not show any statistically significant differences (Mann-Whitney Wilcoxon test, n = 40, p > 0.05). (B)
gne KO larvae display reduced response to tactile stimuli in 'Touch-evoke assay'. Quantification of the assay revealed that gne KO larvae swim significantly less distance, compared to WT larvae, following tactile stimuli at 7 and 8.5 dpf (Mann-Whitney Wilcoxon test, n = 60). (C) Locomotor activity is not affected in gne KO larvae relative to their WT sibling. The mean velocity was calculated for each larva for 60 min, then averaged for each gne genotype at 5 and 7 dpf. (Mann-Whitney Wilcoxon test, n = 133). (D) Zebrafish gne KO heartbeat rate is significantly reduced only at 8.5 dpf (Mann-Whitney Wilcoxon test, n = 80). Significant differences are indicated by *p < 0.01, ****p < 0.00001, standard errors are presented. | PMC9637792 | fcell-10-976111-g003.jpg |
0.405611 | bd4e987b817647d596d2ef9a7c48155c |
gne KO results in skeletal muscle defects which appear at 7 dpf. (A) A reduction in muscle birefringence is observed in gne KO larvae at 7 dpf, compared to WT sibling, and correlates to the severity of the phenotype at 8 dpf. (B) Quantification of the mean birefringence revealed a significant reduction in birefringence at 7 dpf, and highly significant at 8 dpf, compared to WT sibling controls (Mann-Whitney Wilcoxon test, n = 60). Significant differences are indicated by *p < 0.05, **p < 0.01, ****p < 0.00001, standard errors are presented. | PMC9637792 | fcell-10-976111-g004.jpg |
0.417168 | 33f113c1c09e42b49d1037694bd1e4a0 |
gne KO larvae present disorganization of muscle fibers at 5 dpf. (A) H&E staining of muscle cross-sections of gne WT (top) and gne KO (bottom) larvae display abnormally organized myofibers with undefined fiber bundles. Scale bar = 100 µm (left), 50 µm (middle and right). (B) Confocal imaging of whole-mount immunostained larvae at 5 dpf by gne genotype. gne KO exhibits a slightly wavy pattern of the slow muscle fibers (F59) and structurally normal fast fibers (stained with Actinin and Myomesin) with proper localization. Scale bar = 50 µm. | PMC9637792 | fcell-10-976111-g005.jpg |
0.397047 | 22793f64c52146c8bfd43a6b4225f636 |
gne KO larvae present disorganized slow and fast muscle fibers at 8 dpf. (A) Confocal imaging of F-actin stained gne KO muscle at 8 dpf. gne KO larvae show an abnormal Phalloidin staining pattern relative to the WT control at 8 dpf. Scale bar = 100 µm. (B) Confocal imaging of whole-mount immunostained larvae at 8 dpf by gne genotype. Zebrafish gne KO larvae exhibit impaired organization of the slow muscle fibers, stained with F59 antibody. Scale bar = 50 µm. (C) Confocal imaging of whole-mount immunostained larvae at 8 dpf by gne genotype. gne KO larvae exhibit a wavy pattern of the fast muscle fibers, and correct localization of Actin, Actinin, and Myomesin. Scale bar = 50 µm. | PMC9637792 | fcell-10-976111-g006.jpg |
0.461644 | 7e50256d0b144d6a8ea5f2ed46e93cb0 | Maternal and zygotic expression of gne WT and gne KO alleles. (A)
gne maternal inheritance. gne
+/- in-cross results in 3 genotypic groups. gne KO embryos are predicted to receive both gne
+ and gne
− maternal transcripts (blue arrow), but the zygotic transcription will only transcribe gne
− alleles (red arrow). (B) Maternal expression of gne WT and gne mutant allele at 1 and 3 hpf embryos. The relative quantification (RQ) values of gne WT (blue bars) and gne mutant alleles (red bars) are shown by genotype and age. The WT allele was highly expressed in the WT samples and was lower in gne
+/- offspring at 1 and 3 hpf. No amplification was obtained for the gne KO allele. cDNA sample of gne HT at 3 dpf was used as a calibrator for all reactions since it expresses both the WT and the KO alleles. (C) The relative expression of gne WT and gne KO alleles at 3, 5, and 7 dpf. The WT allele was highly expressed in the WT samples but was not found in gne KO at all-time points, and the mutated allele showed the opposite behavior. | PMC9637792 | fcell-10-976111-g007.jpg |
0.427239 | a55de2a999484557b255c944bef735db | Exogenous sialic acid or hGNE transgene expression does not rescue the gne KO larvae. (A) Brightfield and birefringence representative images of 8 dpf larvae that participated in the sialic acid supplementation experiment: gne WT (top), gne KO (middle) and gne KO larvae with 800 μM sialic acid supplementation (bottom). The addition of sialic acid did not ameliorate the muscle phenotype, nor rescued gne KO larvae from mortality at 8–10 dpf. (B) Brightfield and birefringence images of GNE myopathy genetic model larvae display a phenotype similar to gne KO larvae at 8 dpf. (C) No significant differences were detected in morphologic measurements (body length, body height, eye diameter) between wild-type and hGNE
M743T or hGNE
WT transgenic KO models at 8 dpf. (Mann-Whitney Wilcoxon test, p > 0.05). Means of 10 larvae/variable/genotype and corresponding standard deviations are presented. (D) Transgene expression validation. Top: Fluorescent image of a representative 8 dpf Tg(ins:EGFP;hGNE
M743T
;gne
−/−) larva showing EGFP expression in the pancreas. Scale bar = 1 mm. Bottom: Agarose gel electrophoresis of RT-PCR amplification products of the hGNE cDNA and eef1a1a. cDNA samples from both hGNE
M743T and hGNE
WT transgenic KO models show the expected amplification in all tested time points. Non-transgenic WT zebrafish cDNA (WT ZF cDNA) and genomic DNA from transgenic fish (Tg DNA) served as controls for each target. (NTC) no template control. | PMC9637792 | fcell-10-976111-g008.jpg |
0.431875 | 90379d39c6c6407295b38911d96fe7a2 | Transcriptomics analysis of gne KO larvae. (A) PCA plots of gne KO vs. gne WT at 3 dpf, 5 dpf and 7 dpf. gne KO cluster separates from gne WT and gne HT from 5 dpf onwards. (B) MA plots of gne KO vs. gne WT at 3, 5 and 7 dpf. Red and orange dots refer to significant differentially expressed genes, black dots are for non-significant genes. (C) Hierarchical classification of DE genes in gne WT versus gne KO at 3 dpf (3 biological replicates). The figure presents upregulated (red) and downregulated (blue) genes. (CU915827.1 = si:dkey 31e10.5). (D) Venn diagram indicating the number of significant differentially expressed genes among gne KO and gne WT siblings at 3 (green), 5 (yellow) and 7 (blue) dpf. | PMC9637792 | fcell-10-976111-g009.jpg |
0.404019 | ab608c9a225b443cb2b63e24c8952f26 | Gene set enrichment analysis (GSEA) plots of gne KO at 3 (A), 5 (B) and 7 (C) dpf. GSEA plots show the enrichment score on the y axis for genes related to each gene set. Genes are ordered on the x axis according to their GSEA enrichment score. FDR adjusted p-value (<0.05). | PMC9637792 | fcell-10-976111-g010.jpg |
0.423748 | c3abcc0d96be451bbd32a341dd6c4811 | Validation of the transcriptomic data. (A) Comparison of the fold-change values between RNA-sequencing and RT-qPCR data for 8 chosen DE genes shows consistency at 3 dpf and 7 dpf samples (20 embryos/sample, 2 biological replicates). Y axis represents the mean RQ values, standard deviations are presented. (B) Gene expression correlation between RT-qPCR and RNA-seq fold-change at 3 dpf and 7 dpf. Linear regression equations, R
2 and p values are presented (Pearson’s correlation analysis). | PMC9637792 | fcell-10-976111-g011.jpg |
0.436894 | 6c3afd031b3d40a79ea163950277fe6e | Study design and flow of participants | PMC9638202 | 394_2022_3038_Fig1_HTML.jpg |
0.380468 | fc18ae9fd6664e3cb44b0396504ae90c | Twelve- and 24-week changes in 25-hydroxyvitamin D in individual participants | PMC9638202 | 394_2022_3038_Fig2_HTML.jpg |
0.470572 | b9406aede55c431ab2ccab2f4d63c09b | Twelve- and 24-week changes in biochemical parameters in vitamin D and placebo. Data are mean ± SD. Between-group differences analyzed using linear mixed models. 25(OH)D — 25-hydroxyvitamin D; HOMA-IR homeostatic model assessment of insulin resistance, LDL low-density lipoprotein. Pre-training phase = unshaded; training phase = shaded. Placebo: n = 24; Vitamin D: n = 26 | PMC9638202 | 394_2022_3038_Fig3_HTML.jpg |
0.434806 | 5f3dbd0206e7407d99c1280fdcb57783 | Twelve- and 24-week body composition changes in vitamin D and placebo. Data are mean ± SD. Between-group differences analyzed using linear mixed models. *P < 0.05; ALM/H2 appendicular lean mass/height2. Pre-training phase = unshaded; training phase = shaded. Placebo: n = 24; Vitamin D: n = 26 | PMC9638202 | 394_2022_3038_Fig4_HTML.jpg |
0.437545 | 5e855b688bd0454d8a791f63986d5f09 | Twelve- and 24-week body composition changes in vitamin D and placebo. Data are mean ± SD. Between-group differences analyzed using linear mixed models. *P < 0.05; SPPB short physical performance battery. Pre-training phase = unshaded; training phase = shaded. Placebo: n = 24; Vitamin D: n = 26 | PMC9638202 | 394_2022_3038_Fig5_HTML.jpg |
0.401135 | a97c17f5ac88427abcb25e0f278c3668 | Cross-Electrophile Coupling. (A) Overview. (B) Prior Conditions
Developed
for Ball-Mill XEC. (C) This Work: Heteroaryl Products and Acyl Products | PMC9638985 | cs2c03117_0001.jpg |
0.412707 | f6061a9b8cc14c15803dce9b4a97ebca | Mechanochemical XEC
of Twisted Amides, Optimization, Substrate Scope,
and Scale-up | PMC9638985 | cs2c03117_0002.jpg |
0.424898 | 7a1e3495ba874c0188467cf6db6bf4b9 | Mechanochemical XEC of Heteroaryl Bromides, Optimization, Substrate
Scope, Scale-up, Solution Comparisons, and Reductants | PMC9638985 | cs2c03117_0003.jpg |
0.380877 | bd4885e502a14e2ab57f425bd745106b | Control Experiments for the Mechanochemical
XEC of Heteroaryl Bromides
and N-Acyl Imides | PMC9638985 | cs2c03117_0004.jpg |
0.429566 | 0747a67557224af7b9d07084780111ec | Control
Experiments for the Mechanochemical XEC of Heteroaryl Bromides
and N-Acyl Imides | PMC9638985 | cs2c03117_0005.jpg |
0.479498 | 62fb57da459e4d8abba24078869be4e8 | Correlation between C/S rate and NMR according to HDI | PMC9639272 | 12884_2022_5133_Fig1_HTML.jpg |
0.453887 | ed7c14b68ae54016817d7e3b401444f3 | Distribution of the 58 studied pollen stations across the nine climate regions in the contiguous United States. | PMC9640548 | falgy-03-959594-g001.jpg |
0.428259 | 045b3db7273c4e09aaa4000af4ad0e31 | Spatial patterns of monthly mean concentrations of (A) oak pollen in March 2004; (B) oak pollen in April 2004; (C) ragweed pollen in August 2004; (D) ragweed pollen in September 2004, calculated using the CMAQ-Pollen model. | PMC9640548 | falgy-03-959594-g002.jpg |
0.400218 | 88f3177e21f34313a274eb4b0e29e18e | Time slices of spatiotemporal concentration profiles of (A) oak pollen at 11:00 UTC (averaged over Apr 21–Apr 30, 2004); (B) oak pollen at 18:00 UTC (averaged over Apr 21–Apr 30, 2004); (C) ragweed pollen at 14:00 UTC (averaged over Sept 21–Sept 30, 2004); (D) ragweed pollen at 18:00 UTC (averaged over Sept 21–Sept 30, 2004), calculated using the CMAQ-Pollen model. | PMC9640548 | falgy-03-959594-g003.jpg |
0.437476 | ede4a308091248e18f9105774cd55eb8 | Scatterplots of normalized observed seasonal mean concentrations and simulated seasonal mean concentrations in 2004 for (A) oak and (B) ragweed pollen at pollen monitoring stations with available data. | PMC9640548 | falgy-03-959594-g004.jpg |
0.492703 | 702f514ba7cf4b5c8b957781e6ee5bb1 | Seasonal box plots of normalized daily concentrations (simulated with the CMAQ-Pollen model) of oak pollen (top) and ragweed pollen (bottom) compared with observed pollen concentrations in 2004 at pollen monitoring stations. Boxes range from the 25th to 75th percentiles with the dark line denoting median and the dark dots denoting the outliers. | PMC9640548 | falgy-03-959594-g005.jpg |
0.41507 | 6b51d0ecb19d40db929f352a8ed0e954 | Fractional biases of pollen concentrations calculated with the CMAQ-Pollen model for 2004 in the CONUS. (A) Fractional bias of seasonal oak pollen counts; (B) Fractional bias of seasonal ragweed pollen counts. | PMC9640548 | falgy-03-959594-g006.jpg |
0.465456 | c1c129634f9040cdb42fa47bc24adcca | Changes in mean March-April oak pollen concentrations from beginning (2004) to mid-21st century (2047) estimated for the RCP8.5 climate change scenario using the CMAQ-Pollen model. | PMC9640548 | falgy-03-959594-g007.jpg |
0.431934 | a700ff90ada74f569ae264e5b6e84332 | Changes in oak pollen season between 2047 and 2004 estimated for the RCP8.5 climate change scenario using the CMAQ-Pollen model. (A) Changes in oak pollen season start date between 2047 and 2004; (B) Changes in oak pollen season length between 2047 and 2004. Data were mapped only on cells in which the area coverage of oak trees is greater than zero. | PMC9640548 | falgy-03-959594-g008.jpg |
0.45898 | 67717797032745ebb40710e3ed5edd82 | Changes in mean August-September ragweed pollen concentrations from beginning (2004) to mid-21st century (2047) estimated for the RCP8.5 climate change scenario using the CMAQ-Pollen model. | PMC9640548 | falgy-03-959594-g009.jpg |
0.422402 | f61f8a19e76543e1b87b2eec77185b82 | Changes in ragweed pollen season between 2047 and 2004 estimated for the RCP8.5 climate change scenario using the CMAQ-Pollen model. (A) Changes in ragweed pollen season start date between 2047 and 2004; (B) Changes in ragweed pollen season length between 2047 and 2004. Data were mapped only on cells in which the area coverage of ragweed is greater than zero. | PMC9640548 | falgy-03-959594-g010.jpg |
0.467615 | 3048144e1d7849f8a515459298b5ca20 | (A) and (B) computed tomography of the head demonstrating subarachnoid hemorrhage. (C) Anterior-posterior the right internal carotid artery and (D) 3D rotational angiogram demonstrating a fusiform aneurysm of the M1 segment of the right MCA measuring 10.11 × 6.47 mm. Multiple ascuses (arrow) were visible in the inferior wall of aneurysm. | PMC9640772 | fsurg-09-941355-g001.jpg |
0.368748 | febbd6813a6742108b70275bdf53ec61 | (A) patient was treated by embolization with TFD. (B) The stent is completely released and filled with coils through microcatheter. (C) two months later, angiographic follow-up showed partial occlusion of the aneurysm and moderate in-stent stenosis of the ipsilateral middle cerebral artery. (D) The anterior communicating artery was open and the ipsilateral anterior cerebral artery was well developed. | PMC9640772 | fsurg-09-941355-g002.jpg |
0.489406 | 3cdb73f7c3854b34a61ebafa6c894ab9 | DSA images findings 12-months after operation. (A) anteroposterior angiography of the right internal carotid artery. (B) Lateral angiography of the right internal carotid artery. (C) The working position angiography showed that the stenosis at the distal and proximal ends of the stent disappeared. (D) The anteroposterior angiography of the left internal carotid artery showed that the anterior communicating artery was open and the ipsilateral anterior cerebral artery was well developed. | PMC9640772 | fsurg-09-941355-g003.jpg |
0.39609 | 0a5c4d8a62ce4b95803020ebb1663407 | A flowchart demonstrating main study statistical methods and outcomes. | PMC9640973 | gr1.jpg |
0.411887 | ee76c90a661c440a889c7d8878479f76 | Simple regression analysis (r = 0.37; F probability = 0.003) of observed data against bean yield data fitted by multiple regression model. | PMC9640973 | gr2.jpg |
0.43319 | 61b8c554e74c4dbb8eba5721ba808e91 | Shell surface features of the healthy and Polydora-infected Yesso scallops. Polydora mainly parasitizes the left shell by excavating tunnels, while melanization is found on the inner surface. | PMC9641012 | gr1.jpg |
0.513618 | e2c4762bef214a219a2a3efafb92ea69 | Protein expression correlations among different samples from the diseased and healthy groups. A. Principal component analysis indicating clear differences between the diseased and healthy groups. B. Pearson correlation coefficients indicating good reproducibility of the duplicate samples from the two groups. Colours indicate the Pearson correlation coefficient values. | PMC9641012 | gr2.jpg |
0.423301 | 9c8ad5723dcb4a5a9d465cbdfa5f1dcd | Differentially expressed proteins (DEPs) modulated in the Yesso scallop in response to Polydora infection. A. Statistics of upregulated and downregulated DEPs (p < 0.05 and Foldchange ≥1.2 or ≤0.83) in the diseased group. B. Volcano plot showing the upregulated and downregulated DEPs (red and blue dots, respectively) in the diseased group. Grey dots indicate no significance change in expression level. C. Hierarchical clustering analysis showing a significant difference in protein expression between healthy and diseased Yesso scallops. The colour range indicates the protein expression levels, which are centralized between −1.5 and 1.5. Red and blue bars indicate upregulation and downregulation in the diseased group, respectively. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) | PMC9641012 | gr3.jpg |
0.403244 | 348a23bb800f4c3ab625d6571f8b1792 | Distribution of significantly enriched GO functions (level 2) for upregulated and downregulated DEPs in Polydora-infected Yesso scallops. The x-axis represents the biological functions of biological process, cellular component, and molecular function. The y-axis represents the percentage or number of proteins categorized into different functions. | PMC9641012 | gr4.jpg |
0.404072 | 05e1fe963fbd4ed8b622eb5d6b5317f1 | KEGG enrichment analysis showing the significantly enriched pathways for upregulated (A) and downregulated (B) DEPs in Polydora-infected Yesso scallops. The x-axis shows the enrichment score. The left y-axis shows the KEGG pathway. The colour and size of each point represent the p-values and numbers of proteins enriched in a particular pathway. | PMC9641012 | gr5.jpg |
0.451463 | 5a8eb8300b5446e38381358c11174320 | Protein-protein interaction (PPi) network of DEPs in diseased and healthy Yesso scallops. Red circles represent upregulated DEPs, the blue squares represent downregulated DEPs, and the size of the two graphs indicates the number of interacting proteins. The width of the lines indicates the protein interaction evaluation score. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) | PMC9641012 | gr6.jpg |
0.413823 | 8637c31e461c476499162bf1e9687ed6 | Phagocytosis pathway in the Yesso scallop in response to Polydora infection. The mRNA and protein expression levels of DEPs involved in phagocytosis are presented as means ± standard error (n = 3). Asterisks indicate significant differences (*p < 0.05, **p < 0.01). Red and green arrows indicate upregulation and downregulation in Polydora-infected scallops, respectively. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) | PMC9641012 | gr7.jpg |
0.403128 | 74b348377889484cb081af9ffc935c7b | (A) Preoperative computed tomography image showing pseudoaneurysm of the abdominal aorta. (B) Postoperative computed tomography image showing repaired abdominal aorta without aneurysmal change. | PMC9641711 | ivac261f1.jpg |
0.485489 | 2af4179935ca4812aec9e2bebac5a37e | Intraoperative images. (A) Incised lumens before repair. (B) Repaired abdominal aorta using bovine pericardium. f: false lumen; p: pseudoaneurysm; t: true lumen. | PMC9641711 | ivac261f2.jpg |
0.425781 | 0a793d7a5c7049e4b68e22fe766d2dc5 | Cumulative incidence of overall early-onset kidney diseases later in life among children divided into three groups (without DM, with T1DM, and with T2DM). DM, diabetes mellitus; T1DM, type 1 diabetes mellitus; T2DM, type 2 diabetes mellitus | PMC9641804 | 12916_2022_2634_Fig1_HTML.jpg |
0.45316 | 7ca40bcfc36b4114b2bce65029d94c1a | Cumulative incidence of overall early-onset kidney diseases later in life among children by age of diagnosis of diabetes mellitus (0–5, 6–12, and 13–17 years) | PMC9641804 | 12916_2022_2634_Fig2_HTML.jpg |
0.498675 | f334880437c04094b501745ca8772f1c | Plasma neurofilament light chain (pNFL) concentration in the diagnostic groups is shown as scatterplots. The pNFL concentration was higher in the END group compared with the Non-END group (*P < 0.001). | PMC9642090 | fneur-13-1019530-g0001.jpg |
0.458863 | e6fd48e5a11a4a26ac6ab9b1c23a6d97 | Receiver operator characteristic (ROC) curves of variables predicting END 24 h after stroke onset. AUC, area under the curve; NIHSS, NIH stroke scale; pNFL, plasma neurofilament light chain concentration. | PMC9642090 | fneur-13-1019530-g0002.jpg |
0.418195 | 8cb6295aae5444b7b4349d1c3ad7b8e3 | Progression rate of newly diagnosed ALS patients.ALS patients were stratified by the proportion of T cell subsets in the blood (A) and cerebrospinal fluid (B) at the time of diagnosis. The longitudinal evolution of ALS functional rating scale-revised (ALSFRS-R) in relation to the baseline categories of T cell subsets is plotted with 95% confidence intervals. The p value is of the interaction term of time and T cell subset category from the linear mixed model fitted without adjustments. | PMC9643478 | 41467_2022_34526_Fig1_HTML.jpg |
0.42646 | d38f46d7b5fa443586e33c26bd93e9cc | Distinct T cell profiles are associated with differential ALS disease progression.Exploratory factor analysis was used to reduce the flow cytometric data into summary variables and resulted in five factors that explained 89.5% of the total variance (A). ALS patients were stratified by the factors. Longitudinal changes in the ALS functional rating scale-revised (ALSFRS-R) in blood were analysed using linear mixed models with mean and 95% confidence intervals for each category of factors. B Cluster analysis was used to identify patients with similar factor profiles and resulted in four clusters. Standardized and centered parallel profile plots of the individual patients’ factor scores are colored according to cluster membership (C). Disease progression in the different clusters was analysed using a linear mixed model (D). | PMC9643478 | 41467_2022_34526_Fig2_HTML.jpg |
0.468668 | 4fe2d340c713427dbc7b7acd9a4393c5 | Differential cell composition and gene expression in CSF of ALS patients versus controls.t-SNE plots of 10X scRNA-seq data showing leukocyte subsets from five ALS patients and four controls (A). A pairwise comparison of ALS and controls in terms of cell count abundance for every cell type was performed using a two-sided proportions z-test (horizontal dotted lines correspond to P = 0.05) which was followed by Yate’s continuity correction. Correction for multiple testing was done using Benjamini–Hochberg (BH) correction (B). Heat map illustrating the top-up to five most up- and down-regulated genes in different T cell subsets in ALS patients (N = 5) versus controls (N = 4) (C). | PMC9643478 | 41467_2022_34526_Fig3_HTML.jpg |
0.412138 | 966988734fec43a19299613be3b66c44 | Clonal expansion of CD4+ T cell subsets in ALS.t-SNE plots of 10X scRNA-seq data showing T cell subsets and contour plots outlining TCR expansions identified using 10X VDJ scRNA-seq in five ALS patients, two non-inflammatory controls, and two normal pressure hydrocephalus (NPH) controls individuals (A). Quantification of TCR expansion from 10X VDJ scRNA-seq from ALS patients and controls (B) with significance displayed in ascending order (C). For each cell type, p values were calculated using Pearson’s Chi-squared test and Monte Carlo simulation with 2000 replicates. | PMC9643478 | 41467_2022_34526_Fig4_HTML.jpg |
0.39575 | c4b09fb8d9c74b5aba9246b81c5bd61a | Distinct expression of lineage-defining transcription factors among clonally expanded T cells in CSF of ALS patients.t-SNE plots of 10X scRNA-seq data showing expression of GATA3, Eomesodermin, Tbet, and RORγt with the percentage of positive cells (shown in purple) noted (A). Quantification of GATA3, Eomesodermin, Tbet, and RORγt expressing cells among expanded (>5 identical TCR sequences) and non-expanded (≤5 identical TCR sequences) T cells. The p values were calculated using the chi-squared test (B). | PMC9643478 | 41467_2022_34526_Fig5_HTML.jpg |
0.389112 | dff527c16a084556ab333502d99aa3f5 | Fluorescent assignment of different Aβ and tau pathologies in AD brain tissue sections stained with different proteophenes. Images and fluorescence spectra from Aβ deposits (green arrows), including cerebral amyloid angiopathy (CAA) lesions, Aβ cored plaques, diffuse Aβ plaques, and tau pathology (white arrows: neurofibrillary tangles (NFTs), white arrowheads: neuropil threads) in tissue sections stained with 100 nM HS‐84‐E‐Y, HS‐84‐Y‐E, HS‐84‐E‐V or HS‐84‐V‐E. Autofluorescence from lipofuscin is seen in yellow. The staining was performed on adjacent sections and the images were recorded in spectral mode using an excitation at 488 nm and the emission was collected between 450 nm to 690 nm. Scale bar represents 20 μm. | PMC9643645 | CHEM-28-0-g002.jpg |
0.42083 | ec9349d065784f6f8e7cc5796e937c96 | Fluorescent detection of protein aggregates in brain tissue sections with AD pathology stained with proteophenes having different amino acid functionalities along the thiophene backbone. A) Chemical structures, absorption‐ and emission spectra of the Li‐salt of HS‐84‐E‐Y, HS‐84‐Y‐E, HS‐84‐E‐V and HS‐84‐V‐E. B) Overview image of the whole tissue section stained with 100 nM HS‐84‐E‐Y (top left), HS‐84‐Y‐E (top right), HS‐84‐E‐V (bottom left) or HS‐84‐V‐E (bottom right). The staining was performed on adjacent sections and the images correspond to 375 tiles taken with a 10× objective. The tile images were recorded in spectral mode using an excitation at 488 nm and the emission was collected between 450 nm to 700 nm. Scale bar represents 2 mm. | PMC9643645 | CHEM-28-0-g003.jpg |
0.426504 | 8c64b43b6082432a841e090d85eca9c3 | Fluorescent detection of protein aggregates in brain tissue sections with AD pathology stained with a D‐A‐D based proteophene. A) Chemical structures, absorption‐ (blue) and emission spectra (red, purple) of the Li‐salt of HS‐169‐V‐V. The emission spectra were recorded with excitation wavelengths corresponding to the two absorption maxima, 375 nm (red arrow) or 495 nm (purple arrow). B) Spectral image, fluorescence spectra and fluorescence lifetime distribution of cerebral amyloid angiopathy (CAA) lesions (red arrows) in a tissue section stained with 100 nM HS‐169‐V‐V. The images were recorded in spectral mode using an excitation at 561 nm and the emission was collected between 500 nm to 690 nm Scale bar represents 20 μm. C) Intensity images and fluorescence lifetime distributions from CAA lesions (red arrows), cored Aβ plaques (blue arrows), diffuse Aβ plaques (green arrows) or tau pathology (purple arrow) in a tissue section stained with 100 nM HS‐169‐V‐V and 100 nM HS‐84‐V‐E. The images were recorded using an excitation at 490 nm and the fluorescence lifetime distributions were recorded using excitation at 490/565 nm. Scale bar represents 20 μm. | PMC9643645 | CHEM-28-0-g004.jpg |
0.480789 | 75c9fed66ed34f5184b1b3c3270acc93 | Fluorescent assignment of different Aβ and tau pathologies in AD brain tissue sections stained with different proteophenes. Images and fluorescence spectra from immuno‐positive Aβ deposits (green arrows), including cerebral amyloid angiopathy (CAA) lesions, Aβ cored plaques, diffuse Aβ plaques, and tau pathology (white arrows: neurofibrillary tangles (NFTs), white arrowheads: neuropil threads) in tissue sections stained with 100 nM HS‐84‐E‐E, HS‐84‐K‐K, HS‐84‐Y‐Y or HS‐84‐V‐V. Autofluorescence from lipofuscin is seen in blue (top panel) or yellow (ligand staining). The staining was performed on adjacent sections and the images were recorded in spectral mode using an excitation at 488 nm and the emission was collected between 450 nm to 700 nm. Scale bar represents 20 μm. | PMC9643645 | CHEM-28-0-g006.jpg |
0.415998 | e89ccd5a1aa64fe2bc4b6e3e6576bf3f | Fluorescent detection of protein aggregates in brain tissue sections with AD pathology stained with different proteophenes. A) Chemical structure (left) of HS‐84 and an overview image of the whole tissue section stained with 100 nM HS‐84‐E‐E (right). B) Overview image of the whole tissue section stained with 100 nM HS‐84‐E‐E (top left), HS‐84‐K‐K (top right), HS‐84‐Y‐Y (bottom left) or HS‐84‐V‐V (bottom right). The staining was performed on adjacent sections and the images correspond to 375 tiles taken with a 10× objective. The tile images were recorded in spectral mode using an excitation at 488 nm and collecting the emission between 450 nm to 700 nm. Scale bar represents 2 mm. | PMC9643645 | CHEM-28-0-g007.jpg |
0.44491 | f2a870450f5d40558d4544736fa85a1a | Chemical structure and photophysical properties of the novel proteophenes. Chemical structure (left), absorption‐ (blue) and emission (red) spectra (right) of the Li‐salt of HS‐84‐E‐E (A), HS‐84‐K‐K (B), HS‐84‐Y‐Y (C) and HS‐84‐V‐V (D). The spectra were recorded after diluting each ligand to 30 μM in phosphate buffered saline (PBS, 10 mM phosphate, 140 mM NaCl, 2.7 mM KCl, pH 7.4). For the emission spectra, an excitation wavelength corresponding to the absorption maximum of the respective ligand was used. | PMC9643645 | CHEM-28-0-g009.jpg |
0.403732 | 4173e0182a00401d8e4d000aed73f34c | flowchart | PMC9643794 | PAMJ-42-296-g001.jpg |
0.428702 | 30b6122dfb9245c487a1b98a37d5e562 | risk of bias summary for included studies according to Cochrane risk of bias domain for randomised control trials | PMC9643794 | PAMJ-42-296-g002.jpg |
0.482341 | 413ae8bad946470eaf7625064707a6f3 | Impact of COVID-19 pandemic on the pathway to TB diagnosis | PMC9645304 | 12879_2022_7832_Fig1_HTML.jpg |
0.438191 | 284deb4a33914a9aa000405b1c66fbae | Schematic of the in vitro surfactant exposure set-up.Aerosol exposed surfactant was generated using a syringe containing BLES connected directly to an EC device which allowed aerosol to be drawn into the syringe and, after 30 seconds, expelled. This procedure was repeated 30 times. | PMC9645651 | pone.0272475.g001.jpg |
0.466783 | abb1f52324574c84b1d2e7c89021d73c | Vehicle compression/expansion.BLES exposed to vehicle (■) compared to air control (○). A. Representative surface tension vs area isotherm at the fifth compression/expansion cycle. B. Representative surface tension vs area isotherm at the tenth compression/expansion cycle. C. Minimum surface tensions across 20 compression/expansion cycles. D. Maximum surface tensions across 20 compression/expansion cycles. *P<0.05 compared to air control. | PMC9645651 | pone.0272475.g002.jpg |
0.471029 | 61d991556bc147d7aeed5515ddac0d88 | Minimum surface tensions of experimental variables.Minimum surface tensions (± SEM) across 20 compression/expansion cycles for BLES exposed to three experimental variables, compared to air control. A. Three different vehicle compositions with increasing VG content. B. Three different EC devices. C. Three different wattages set on a programmable EC to alter aerosol temperature. D. BLES mixed with three different volumes of vehicle e-liquid. N = 3 *P<0.05 compared to air control. | PMC9645651 | pone.0272475.g003.jpg |
0.414279 | 935b52c52d364d34a4698b29d8325278 | Minimum surface tensions of flavoured e-liquids.BLES exposed to aerosols containing nicotine and/or flavouring additives compared to air control and unflavoured vehicle at the fifth compression/expansion cycle (± SEM). Each flavour on the x-axis represents BLES exposed to air, unflavoured vehicle, and vehicle + flavouring aerosols. N = 3–4 *P<0.05 compared to air control, #P<0.05 compared to vehicle. | PMC9645651 | pone.0272475.g004.jpg |
0.444181 | 4192332f96af434b902ec2c74ad56c97 | Menthol compression/expansion data.BLES exposed to menthol flavoured aerosol (▲) compared to vehicle (■) and air control (○). A. Representative surface tension vs area isotherm at the fifth compression/expansion cycle. B. Representative surface tension vs area isotherm at the tenth compression/expansion cycle. C. Minimum surface tensions (± SEM) across 20 compression/expansion cycles. D. Maximum surface tensions (± SEM) across 20 compression/expansion cycles. (N = 5) *P<0.05 compared to air control, #P<0.05 compared to vehicle. | PMC9645651 | pone.0272475.g005.jpg |
0.435876 | e1ca204e568f49cb817d1e605a364161 | Red wedding compression/expansion data.BLES exposed to red wedding flavoured aerosol (▲) compared to vehicle (■) and air control (○). A. Representative surface tension vs area isotherm at the fifth compression/expansion cycle. B. Representative surface tension vs area isotherm at the tenth compression/expansion cycle. C. Minimum surface tensions (± SEM) across 20 compression/expansion cycles. D. Maximum surface tensions (± SEM) across 20 compression/expansion cycles. (N = 3) *P<0.05 compared to air control, #P<0.05 compared to vehicle. | PMC9645651 | pone.0272475.g006.jpg |
0.417158 | 7fadfe34aa3c4237b51fcb6a1cb1b8b6 | XRD pattern of the different sintered Cr2O3/Fe2O3/LSG composites | PMC9646563 | 11356_2022_21694_Fig1_HTML.jpg |
0.391774 | d19ea046803048dfb34f2a102d4e6cec | Microstructure of the different sintered Cr2O3/Fe2O3/LSG composites | PMC9646563 | 11356_2022_21694_Fig2_HTML.jpg |
0.448991 | 3ca8df4b2d604af8b4dee20522bf203e | UV-VIS absorbance spectrum of the different sintered Cr2O3/Fe2O3/LSG composites | PMC9646563 | 11356_2022_21694_Fig3_HTML.jpg |
0.490174 | 4bfcb6d18ea74c6fbcf5a29eabd2fdbd | UV-VIS reflectance spectrum of the different sintered Cr2O3/Fe2O3/LSG composites | PMC9646563 | 11356_2022_21694_Fig4_HTML.jpg |
0.443069 | 19890f2fc1d347149f505e97a4449b4b | Band gap energy of the different Cr2O3/Fe2O3/LSG composites | PMC9646563 | 11356_2022_21694_Fig5_HTML.jpg |
0.522363 | bd6fb1ee5b1840faab1c70efaadddb51 | Variation of refractive index with calculated band gap values of the sintered Cr2O3/Fe2O3/LSG composites | PMC9646563 | 11356_2022_21694_Fig6_HTML.jpg |
0.52596 | ede0861b13e9431aba462dddf3975b9d | Magnetic curve of the sintered Cr2O3/Fe2O3/LSG composites | PMC9646563 | 11356_2022_21694_Fig7_HTML.jpg |
0.424109 | 8e612053da4648d09ca52c4a4282bc2d | Venn diagram showing shared and unique OTU of PKSZ, RPL, and PSC. PKSZ: Pinus koraiensis Sieb. et Zucc., RPL: Robinia pseudoacacia L., PSC: Populus simonii Carr | PMC9646614 | 11356_2022_21690_Fig1_HTML.jpg |
0.488786 | c671a676e5284e658dcb9e76dcf5d611 | Ectomycorrhizal fungal community diversity among different samples. Different capital letters in same row indicated the significant difference at 0.01 level, and different lowercase letters in same row indicated the significant difference at 0.05. level. PKSZ: Pinus koraiensis Sieb. et Zucc., RPL: Robinia pseudoacacia L., PSC: Populus simonii Carr | PMC9646614 | 11356_2022_21690_Fig2_HTML.jpg |
0.501673 | 402ffd00b4744fde82f22140ba510229 | The relative abundance of ectomycorrhizal fungl community at phylum (A) and genus (B) levels. PKSZ: Pinus koraiensis Sieb. et Zucc., RPL: Robinia pseudoacacia L., PSC: Populus simonii Carr | PMC9646614 | 11356_2022_21690_Fig3_HTML.jpg |
0.494912 | 69f8f0e50aba4ce8aa07f33ec41b930d | The ectomycorrhizal fungal community beta diversity among different samples. Each point in the figure represents a sample, and points with different colors indicate different samples (groups). Since NMDS adopts rank ordering, it can be approximated that the closer (far) the distance between two points is, the smaller the difference (larger) of the microbial communities in the two samples is. We provide the elliptical dotted circle, which is the 95% confidence ellipse. PKSZ: Pinus koraiensis Sieb. et Zucc., RPL: Robinia pseudoacacia L., PSC: Populus simonii Carr | PMC9646614 | 11356_2022_21690_Fig4_HTML.jpg |
0.391081 | 8196e8dc2ee246899ca90d1f8770ccb4 | Least discriminant analysis (LDA) effect size taxonomic cladogram. A taxonomic cladogram showing the taxonomic hierarchies of major taxa from phylum to genus (from inner circle to outer circle) in the sample community. Node size corresponds to the average relative abundance of that taxon; hollow nodes represent taxa that are not significantly different between groups, while nodes in other colors (e.g., green and red) indicate that these taxa exhibit significant between-group differences, and abundance is higher in the grouped samples represented by this color. Letters identify the names of taxa that differ significantly between groups. PKSZ: Pinus koraiensis Sieb. et Zucc., RPL: Robinia pseudoacacia L., PSC: Populus simonii Carr | PMC9646614 | 11356_2022_21690_Fig5_HTML.jpg |
0.459251 | fa1234a254b142e4a57676ad0f21df85 | The contribution of soil properties to ectomycorrhizal fungal community composition at the phylum (A) and genus (B) level. Different shapes represent different samples; blue triangles in the figure represent different bacteria. The angle between species and environmental factors represents the positive and negative correlations between species and environmental factors. Vertical lines are drawn from different samples to each environmental factor, and the closer the projection points are, the more similar the attribute values of the environmental factor between the samples are. That is, the environmental factors have the same degree of influence on the samples. PKSZ: Pinus koraiensis Sieb. et Zucc., RPL: Robinia pseudoacacia L., PSC: Populus simonii Carr. TC, total carbon; TN, total nitrogen; C/N, C to N ration; AN, available nitrogen; TP, total phosphorus; AP, available phosphorus; AK, available potassium | PMC9646614 | 11356_2022_21690_Fig6_HTML.jpg |
0.581407 | 98e1aa147d464222bf3456b673f01008 | Examples of modified quinolinone cores that induced apoptosis in various cancer cells. | PMC9646836 | 41598_2022_23640_Fig1_HTML.jpg |
0.558226 | 0872f8b1aaac44cea990f5f905db0bbc | Synthetic pathways for the preparation of new tetrahydroquinolinone derivatives: (a) RCH2X, K2CO3/DMF, 60 °C, 5 h; (b) 24% NH3
aq, 50 °C, 24–72 h; (c) TsOH/toluene, reflux, 12 h; (d) PhP(O)Cl2, 160 °C, 16 h; (e) Ag2CO3, CH3I/CHCl3, RT, 12 h. | PMC9646836 | 41598_2022_23640_Fig2_HTML.jpg |
0.377018 | f0e998dffa6c4ea7bcab006f5227c0f2 | Effect of 4a on colony formation and cell viability. (a) Representative photos of the colony formation assay after the treatment of A549 cells with increasing concentrations of 4a. (b) Quantification of the colony formation assay. (c) Effect of 4a on cell viability after incubation with compound for 72 h. Data represent the mean ± SEM of n = 3 independent experiments. *p < 0.01, **p < 0.001, ***p < 0.0001, and ****p < 0.00001. | PMC9646836 | 41598_2022_23640_Fig3_HTML.jpg |
0.43228 | bf940d47f17e49d5adbefab2f87f770f | Analysis of cell cycle distribution after treatment of A549 cells with 4a. Data represent the mean ± SEM of n = 3 independent experiments. *p < 0.01, **p < 0.001, ***p < 0.0001, and ****p < 0.00001. | PMC9646836 | 41598_2022_23640_Fig4_HTML.jpg |
0.458687 | 07e42ad05dd1432f8f000b414b129f8e | Detection of apoptosis by flow cytometry. (a) Representative dot plots after treatment of A549 cells with 4a. (b) Quantitation of A549 cells after Annexin V-FITC/7-AAD staining. (c) Detection of caspase-3/7 activation in 4a-treated A549 cells, presented as representative histograms. (d) Quantification of analysis from (c). Data represent the mean ± SEM of n = 3 independent experiments. *p < 0.01, **p < 0.001, ***p < 0.0001, and ****p < 0.00001. | PMC9646836 | 41598_2022_23640_Fig5_HTML.jpg |
0.466931 | 596af43769144e15a76bf29f546115c2 | Western blotting analysis showing the effects of 4a on the expression of apoptosis-related proteins in the A549 cell line. Full-length Western blots are presented in the supplementary information. | PMC9646836 | 41598_2022_23640_Fig6_HTML.jpg |
0.589565 | fcf70d6165cd47a891443c4659ced7cb | Conclusion of structure–activity relationship studies of the presented tetrahydroquinolinone derivatives. | PMC9646836 | 41598_2022_23640_Fig7_HTML.jpg |
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