prognosis/cardio-docs-qa · Datasets at Hugging Face

When did Otto and colleagues publish their guideline?

February 2, 2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did Otto and colleagues publish their guideline?. ### Response: February 2, 2021.

How much warfarin do women with mechanical prostheses need to take?

>5 mg/d

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much warfarin do women with mechanical prostheses need to take?. ### Response: >5 mg/d.

What is the target anti-Xa level for 4 to 6 hours after dose?

0.8 to 1.2 U/mL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the target anti-Xa level for 4 to 6 hours after dose?. ### Response: 0.8 to 1.2 U/mL.

How long after dose should LMWH be adjusted?

4 to 6 hours

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long after dose should LMWH be adjusted?. ### Response: 4 to 6 hours.

At least how many times per day for all 3 trimesters may be considered?

2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: At least how many times per day for all 3 trimesters may be considered?. ### Response: 2.

For pregnant women with mechanical prostheses who require a dose of warfarin 5 mg/d to maintain a therapeutic INR, dose-adjusted LMWH at least twice per day?

all 3 trimesters

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For pregnant women with mechanical prostheses who require a dose of warfarin 5 mg/d to maintain a therapeutic INR, dose-adjusted LMWH at least twice per day?. ### Response: all 3 trimesters.

What may be considered for pregnant women with mechanical prostheses?

aspirin 75 to 100 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered for pregnant women with mechanical prostheses?. ### Response: aspirin 75 to 100 mg daily.

How many times per day is therapeutic INR?

75 to 100 mg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many times per day is therapeutic INR?. ### Response: 75 to 100 mg.

What is dose-adjusted LMWH at least twice per day during the first trimester?

For pregnant women with mechanical prostheses who require a dose of warfarin ≤5 mg/d to maintain a therapeutic INR

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is dose-adjusted LMWH at least twice per day during the first trimester?. ### Response: For pregnant women with mechanical prostheses who require a dose of warfarin ≤5 mg/d to maintain a therapeutic INR.

Warfarin for the second and third trimesters?

dose-adjusted LMWH at least 2 times per day

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Warfarin for the second and third trimesters?. ### Response: dose-adjusted LMWH at least 2 times per day.

What may be considered in addition to anticoagulation if needed for other indications?

aspirin 75 to 100 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What may be considered in addition to anticoagulation if needed for other indications?. ### Response: aspirin 75 to 100 mg daily.

For pregnant women with mechanical prostheses, LMWH should not be administered unless anti-Xa levels are monitored 4 to 6 hours after administration and dose is adjusted according to levels?

0.8 to 1.2 U/mL

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: For pregnant women with mechanical prostheses, LMWH should not be administered unless anti-Xa levels are monitored 4 to 6 hours after administration and dose is adjusted according to levels?. ### Response: 0.8 to 1.2 U/mL.

What is the name of the direct thrombin inhibitor?

dabigatran

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the direct thrombin inhibitor?. ### Response: dabigatran.

What should not be administered to patients with mechanical valve prostheses?

anticoagulation

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should not be administered to patients with mechanical valve prostheses?. ### Response: anticoagulation.

How is the use of anti-Xa direct oral anticoagulants evaluated?

not been assessed

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the use of anti-Xa direct oral anticoagulants evaluated?. ### Response: not been assessed.

What is not recommended in pregnancy?

The use of anti-Xa direct oral anticoagulants with mechanical heart valves

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is not recommended in pregnancy?. ### Response: The use of anti-Xa direct oral anticoagulants with mechanical heart valves.

What is at increased risk for pregnant women with mechanical heart valves?

serious maternal complications

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is at increased risk for pregnant women with mechanical heart valves?. ### Response: serious maternal complications.

How is the risk of poor fetal outcomes?

high

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How is the risk of poor fetal outcomes?. ### Response: high.

What percentage of women with mechanical heart valves have a serious maternal or fetal complication during pregnancy?

More than one-third

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What percentage of women with mechanical heart valves have a serious maternal or fetal complication during pregnancy?. ### Response: More than one-third.

What is the most effective anticoagulant at preventing thrombotic complications?

Warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the most effective anticoagulant at preventing thrombotic complications?. ### Response: Warfarin.

All women with mechanical heart valves require uninterrupted therapeutic anticoagulation throughout pregnancy?

The choice of anticoagulation strategy is challenging

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: All women with mechanical heart valves require uninterrupted therapeutic anticoagulation throughout pregnancy?. ### Response: The choice of anticoagulation strategy is challenging.

What crosses the placenta and can cause miscarriage, spontaneous abortion, war-farin embryopathy, or fetal intracranial hemorrhage?

warfarin

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What crosses the placenta and can cause miscarriage, spontaneous abortion, war-farin embryopathy, or fetal intracranial hemorrhage?. ### Response: warfarin.

Women with me-chanical heart valves on LMWH are at increased risk of what?

thrombotic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Women with me-chanical heart valves on LMWH are at increased risk of what?. ### Response: thrombotic events.

What is an increased risk of when LMWH is im-properly dosed, monitored, or administered?

thrombotic events

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an increased risk of when LMWH is im-properly dosed, monitored, or administered?. ### Response: thrombotic events.

What type of CKD has been confirmed in patients with or without diabetes?

albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of CKD has been confirmed in patients with or without diabetes?. ### Response: albuminuria.

What group believes patients and providers would want to avoid hyperkalemia and AKI?

The Work Group

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What group believes patients and providers would want to avoid hyperkalemia and AKI?. ### Response: The Work Group.

What does dual RASi therapy decrease proteinuria?

very high levels of albuminuri

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does dual RASi therapy decrease proteinuria?. ### Response: very high levels of albuminuri.

What is a consideration for implementation?

Resource use and costs

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a consideration for implementation?. ### Response: Resource use and costs.

What type of therapy is used to treat very high levels of albuminuriain selected patients?

dual therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of therapy is used to treat very high levels of albuminuriain selected patients?. ### Response: dual therapy.

There is no RCT data on what?

safety orkidney

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: There is no RCT data on what?. ### Response: safety orkidney.

What are dedicated clinics superior to?

historical controls

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are dedicated clinics superior to?. ### Response: historical controls.

What is insuf ficient todifferentiate between men and women for this recommenda-tion?

294There is insuf ﬁcient information

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is insuf ficient todifferentiate between men and women for this recommenda-tion?. ### Response: 294There is insuf ﬁcient information.

What should be discouraged for patients with CKD?

dual therapys

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be discouraged for patients with CKD?. ### Response: dual therapys.

What is the belief that dual therapies of RASi are beneficial compared to monotherapies stemmed only from?

theimprovement in albuminuria with dual therapy

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the belief that dual therapies of RASi are beneficial compared to monotherapies stemmed only from?. ### Response: theimprovement in albuminuria with dual therapy.

What did the addition of an MRA to an ACEi or ARB for renoprotection inpatients with diabetes and kidney disease result in?

a reduc-tion of albuminuria but a higher risk of hyperkalemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the addition of an MRA to an ACEi or ARB for renoprotection inpatients with diabetes and kidney disease result in?. ### Response: a reduc-tion of albuminuria but a higher risk of hyperkalemia.

What was reduced by adding spironolactone, epler-enone, or finerenone?

albuminuria

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was reduced by adding spironolactone, epler-enone, or finerenone?. ### Response: albuminuria.

No adequately powered study has been completed with spi-ronolactone or eplerenone?

Beyondalbuminuria, no adequately powered study examining GFRand kidney failure outcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: No adequately powered study has been completed with spi-ronolactone or eplerenone?. ### Response: Beyondalbuminuria, no adequately powered study examining GFRand kidney failure outcomes.

The FIDELIOtrial showed kidney and cardiovascular protection by finer-enone despite its modest effect on what?

SBP

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: The FIDELIOtrial showed kidney and cardiovascular protection by finer-enone despite its modest effect on what?. ### Response: SBP.

What is the FIGARO trial testing on the background of an ACEi or ARB in patients with diabetes and kidney disease?

erenone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the FIGARO trial testing on the background of an ACEi or ARB in patients with diabetes and kidney disease?. ### Response: erenone.

What are the benefits of dual versus monotherapy in people with CKD without diabetes?

major kidneyoutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are the benefits of dual versus monotherapy in people with CKD without diabetes?. ### Response: major kidneyoutcomes.

What has not been wellstudied in people with CKD without diabetes and proteinuria?

The bene ﬁts of dual versus monotherapy on major kidneyoutcomes

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What has not been wellstudied in people with CKD without diabetes and proteinuria?. ### Response: The bene ﬁts of dual versus monotherapy on major kidneyoutcomes.

What should be curtailing the risks of hyperkalemia and AKI?

Future trials

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be curtailing the risks of hyperkalemia and AKI?. ### Response: Future trials.

What should be directed to identify individuals who will bene fit or experience the benefits of personalized medicine?

research

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be directed to identify individuals who will bene fit or experience the benefits of personalized medicine?. ### Response: research.

When did ACC/AHA/SCAI Focused Update on Primary PCI1243 occur?

MARCH 15, 2016:1235 –50 2015

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: When did ACC/AHA/SCAI Focused Update on Primary PCI1243 occur?. ### Response: MARCH 15, 2016:1235 –50 2015.

How many people with essential hypertension had a stroke in December 2014?

9193

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people with essential hypertension had a stroke in December 2014?. ### Response: 9193.

What was the duration of the stroke in 9193 people?

4 years

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the duration of the stroke in 9193 people?. ### Response: 4 years.

How long did it take for BP reductions to be similar for each group?

305

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How long did it take for BP reductions to be similar for each group?. ### Response: 305.

How many people had diabetes mellitus?

5137

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many people had diabetes mellitus?. ### Response: 5137.

How much reduction was there in major vascular events?

24%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction was there in major vascular events?. ### Response: 24%.

What was the nonsignificant reduction in stroke among those treated?

21% reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the nonsignificant reduction in stroke among those treated?. ### Response: 21% reduction.

What was the RR of stroke among those treated with the ARB?

0.79

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the RR of stroke among those treated with the ARB?. ### Response: 0.79.

How many patients with type 2 diabetes mellitus had a fixed combination of perindopril and indapamide or matching pla-cebo?

11 140

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with type 2 diabetes mellitus had a fixed combination of perindopril and indapamide or matching pla-cebo?. ### Response: 11 140.

What was the mean reduction in BP after 4.3 years of follow-up?

5.6/2.2 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the mean reduction in BP after 4.3 years of follow-up?. ### Response: 5.6/2.2 mm Hg.

How much was the risk of a composite of major macrovascular and microvascu-lar events reduced by?

9%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much was the risk of a composite of major macrovascular and microvascu-lar events reduced by?. ### Response: 9%.

How many antihypertensive treatment strategies were used in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)?

2

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many antihypertensive treatment strategies were used in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)?. ### Response: 2.

What was the HR of the ASCOT trial?

0.59

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the HR of the ASCOT trial?. ### Response: 0.59.

How many patients with diabetes mellitus were compared to amlodipine-based or atenolol with addition of thiazide?

5137

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with diabetes mellitus were compared to amlodipine-based or atenolol with addition of thiazide?. ### Response: 5137.

What was the target BP?

<130/80 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the target BP?. ### Response: <130/80 mm Hg.

Why was the trial terminated early?

reductions in mortality and stroke with the amlodipine-based regimen

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Why was the trial terminated early?. ### Response: reductions in mortality and stroke with the amlodipine-based regimen.

What did the amlodipine-based regimen reduce in deaths and strokes?

incidence of total cardiovascular events and procedures

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the amlodipine-based regimen reduce in deaths and strokes?. ### Response: incidence of total cardiovascular events and procedures.

What was the difference in mortality and stroke reductions with the atenolol based regimen?

24% reduction (RR, 0.76; 95% CI, 0.58–0.98) in major vascular events and a nonsignificant 21% reduction

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the difference in mortality and stroke reductions with the atenolol based regimen?. ### Response: 24% reduction (RR, 0.76; 95% CI, 0.58–0.98) in major vascular events and a nonsignificant 21% reduction.

In patients with diabetes mellitus, what was the reduction in total cardiovascular events and procedures?

the amlodipine-based therapy reduced the incidence

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: In patients with diabetes mellitus, what was the reduction in total cardiovascular events and procedures?. ### Response: the amlodipine-based therapy reduced the incidence.

How much reduction in fatal and nonfatal strokes did the open-label therapy cause?

25%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How much reduction in fatal and nonfatal strokes did the open-label therapy cause?. ### Response: 25%.

What was the reduction in fatal and nonfatal strokes?

25%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the reduction in fatal and nonfatal strokes?. ### Response: 25%.

How many participants were in the open-label ACCORD trial?

4733

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many participants were in the open-label ACCORD trial?. ### Response: 4733.

What were the treatment goals for the more intensive and less intensive groups?

0.32% (more intensive) and 0.53%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What were the treatment goals for the more intensive and less intensive groups?. ### Response: 0.32% (more intensive) and 0.53%.

What did not reduce the rate of the composite outcome of fatal and nonfatal major CVD events?

Randomization to the more intensive goal

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did not reduce the rate of the composite outcome of fatal and nonfatal major CVD events?. ### Response: Randomization to the more intensive goal.

What was a prespecified secondary end point occur-ring at annual rates of 0.32%?

Stroke

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was a prespecified secondary end point occur-ring at annual rates of 0.32%?. ### Response: Stroke.

How many patients were randomized to treatment with ACCOMPLISH?

11 506

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients were randomized to treatment with ACCOMPLISH?. ### Response: 11 506.

How many of the patients were with diabetes mellitus?

5137

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many of the patients were with diabetes mellitus?. ### Response: 5137.

What was the average annual rate of more intensive and less intensive treatment?

0.32%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the average annual rate of more intensive and less intensive treatment?. ### Response: 0.32%.

What was the primary end point of the study?

<130/80 mm Hg

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the primary end point of the study?. ### Response: <130/80 mm Hg.

What type of diabetes was randomized to benazepril plus amlodipine?

mellitus

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What type of diabetes was randomized to benazepril plus amlodipine?. ### Response: mellitus.

What should be closely monitored during the introduction of aldosterone antagonists and during intercurrent illnesses?

Plasma potassiumlevels and kidney function

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be closely monitored during the introduction of aldosterone antagonists and during intercurrent illnesses?. ### Response: Plasma potassiumlevels and kidney function.

What is associated with a risk of GFR reduction?

dehydration

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is associated with a risk of GFR reduction?. ### Response: dehydration.

What are aldosterone antagonists recommended for in patients without CKD?

the treatment of severe cardiac failure

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are aldosterone antagonists recommended for in patients without CKD?. ### Response: the treatment of severe cardiac failure.

What is used after acute myocardial infarction caused by cardiac failure?

aldosterone antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is used after acute myocardial infarction caused by cardiac failure?. ### Response: aldosterone antagonists.

What is resistant to other therapies?

essential hypertension

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is resistant to other therapies?. ### Response: essential hypertension.

What is unclear if this information can be extrapolated to CKD patients?

the risks associated with the use ofaldosterone antagonists, particularly of hyperkalemia, may beincreased

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is unclear if this information can be extrapolated to CKD patients?. ### Response: the risks associated with the use ofaldosterone antagonists, particularly of hyperkalemia, may beincreased.

What does eplerenone do when added to ACE-I or ARB therapy?

reduction in AER

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does eplerenone do when added to ACE-I or ARB therapy?. ### Response: reduction in AER.

How many patients with CKD with elevated urine albumin levels were included in the largest relevant RCT available?

177

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: How many patients with CKD with elevated urine albumin levels were included in the largest relevant RCT available?. ### Response: 177.

What was the dose of enalapril given to 177 patients?

50 or 100 mg daily

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the dose of enalapril given to 177 patients?. ### Response: 50 or 100 mg daily.

What did the addition of eplerenone to enalapril result in?

areduction in AERs of 40 to 50%

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What did the addition of eplerenone to enalapril result in?. ### Response: areduction in AERs of 40 to 50%.

What was the reduction in AER in the CKD patients receiving analdosterone antagonist in addition to an ACE-I or ARB?

urine albumin excretion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was the reduction in AER in the CKD patients receiving analdosterone antagonist in addition to an ACE-I or ARB?. ### Response: urine albumin excretion.

What is an antagonist in addition to an ACE-I or ARB?

aldosterone

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is an antagonist in addition to an ACE-I or ARB?. ### Response: aldosterone.

Small reductions in GFR and systolic BP have been reported.

103,107,108

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Small reductions in GFR and systolic BP have been reported.. ### Response: 103,107,108.

What is a risk?

Hyperkalemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is a risk?. ### Response: Hyperkalemia.

What was not used in the smaller studies?

Thiazide diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not used in the smaller studies?. ### Response: Thiazide diuretics.

What was not used in the larger RCT cited above?

Thiazide diuretics

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What was not used in the larger RCT cited above?. ### Response: Thiazide diuretics.

What risk was similar among participants receiving enalapril alone and those receiving the combination ofeplerenone and elapron in that trial?

hyperkalemia

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What risk was similar among participants receiving enalapril alone and those receiving the combination ofeplerenone and elapron in that trial?. ### Response: hyperkalemia.

Aldosteroneantagonists have anti-albuminuric, anti-hyperten-sive, and what other effect?

decrease urine albumin excretion

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: Aldosteroneantagonists have anti-albuminuric, anti-hyperten-sive, and what other effect?. ### Response: decrease urine albumin excretion.

What are potas-sium-sparing diuretics that may be combined with thiazide?

Aldosterone antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What are potas-sium-sparing diuretics that may be combined with thiazide?. ### Response: Aldosterone antagonists.

What enhances potassium loss in theurine?

Aldosterone antagonists

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What enhances potassium loss in theurine?. ### Response: Aldosterone antagonists.

What should be exercised when aldosteroneantagonists are combined with ACE-Is, ARBs or otherpotassium-sparing diuretics?

Great care

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What should be exercised when aldosteroneantagonists are combined with ACE-Is, ARBs or otherpotassium-sparing diuretics?. ### Response: Great care.

What is the name of the longitudinal subgroup analysis in SPRINT?

longitudinals

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the longitudinal subgroup analysis in SPRINT?. ### Response: longitudinals.

What does intensive blood pressure lowering do for kidney tubule injury?

Effects

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What does intensive blood pressure lowering do for kidney tubule injury?. ### Response: Effects.

What is kidney tubule injury in CKD?

Effects of intensive bloodpressure lowering

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is kidney tubule injury in CKD?. ### Response: Effects of intensive bloodpressure lowering.

What is the name of the longitudinalsubgroup analysis in SPRINT?

Effects of intensive bloodpressure lowering on kidney tubule injury in CKD

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What is the name of the longitudinalsubgroup analysis in SPRINT?. ### Response: Effects of intensive bloodpressure lowering on kidney tubule injury in CKD.

What year did Intern Med publish 169:610–618?

2018

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year did Intern Med publish 169:610–618?. ### Response: 2018.

What year was Kidney International published?

2021

Below is an instruction that describes a task. Write a response that appropriately completes the request. ### Instruction: What year was Kidney International published?. ### Response: 2021.