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L216-218 “The text was then coded by two researchers” I could not find agreement data reported later.
| null | null |
L285 Figure 4. This is a great figure, thank you for including it. However, an explanation would be useful for those readers who are not familiar with this type of depicting.
| 1 | 2 |
ani12040482_perova
| 0 |
However, I don't think the figures were referred to in the text (unless that was the errors highlighted below?)
| null | null |
L291 The odds ratio (OR) is 5.38 and not 4.38 in Table 1.
| 1 | 2 |
ani12040482_perova
| 0 |
L148 Please explain why a periof of 7 days were asked to be reported
| null | null |
L293-295 “The final variable associated with October SRB status was the difference in the number of days dogs were left alone for between the February baseline and lockdown”.
| 1 | 2 |
ani12040482_perova
| 0 |
Author Response Thank you for your time in reviewing this manuscript and for your constructive, helpful feedback.
| null | null |
OR was 0.81 here. Please explain the relationship between the variables.
| 1 | 2 |
ani12040482_perova
| 0 |
The authors examined how separation-related behaviors in pet dogs changed in relation to time spent away from home by UK owners in February 2020 (pre-pandemic), May-July 2020 (first lockdown during the pandemic), and October-November 2020 (local tier-system for restrictions; follow-up).
| null | null |
L298 Table 1 legend: Add what bold indicates L307 The odds ratio (OR) is 4.97 in Table 1 and not
| 1 | 2 |
ani12040482_perova
| 0 |
This is a well written and clear manuscript which would be of interest to academics, practitioners and dog owners.
| null | null |
L307 The odds ratio (OR) is 4.97 in Table 1 and not 3.60 Thank you!
| 1 | 2 |
ani12040482_perova
| 0 |
Larger issues: I would like to see the authors address a few different angles in the discussion 1.
| null | null |
L314 Table 2: bold is not used here although it was used in Table 1
| 1 | 2 |
ani12040482_perova
| 0 |
The authors have hardly studied all the publications on how dogs behave when daily routines were changed, so the term "first study" is exaggerated.
| null | null |
L333 table 3: same: bold is not used here
| 1 | 2 |
ani12040482_perova
| 0 |
According to the authors, the main finding is that dogs whose leaving time reduced the most during the lockdown were most at risk of developing new SRBs.
| null | null |
L382 Please refer to Flannigan and Dodman (2001) here (owner’s work schedule affects separation problems). Flannigan, G., & Dodman, N. H. (2001). Risk factors and behaviors associated with separation anxiety in dogs. Journal of the American Veterinary Medical Association, 219(4), 460-466.
| 1 | 2 |
ani12040482_perova
| 0 |
Results: These were generally well-detailed with clear layout considering scope of results.
| null | null |
L395-397 “This value is likely to be an underestimate” The underestimation has already occurred during the baseline.
| 1 | 2 |
ani12040482_perova
| 0 |
Authors addressed all my requests and suggestions to my fullest satisfaction.
| null | null |
Figure 7b is not very credible, when U937 become macrogphages adhere to the plate and assume the morphology of a macrophage. the figure is not clear and not well visible.
| 1 | 2 |
antiox11040683_makarova
| 0 |
Future work could extend our analysis and examine the antioxidant capacity of the BCAT1 CXXC motif in other FAB subtype models, for example HL60 (AML, M2) and NB4 (AML M3 aka APL) [45].”
| null | null |
The authors should also show the flow cytometers panels related to cd68 and cd14.
| 1 | 2 |
antiox11040683_makarova
| 0 |
Because of their pro-monocytic phenotype, many regard the U937 cell line to be representative of an AML subtype M5, under the French-American-British (FAB) classification system [43–46].
| null | null |
Small comment, the supplementary Fig. S4B would need some compensation work....this would be better to correct before final approval for publication ( up to editor).
| 1 | 2 |
antiox11040683_makarova
| 0 |
We agree with your comments and have addressed these to the best of our ability in the revised manuscript.
| null | null |
Also the gating strategy on Fig. 4d ( is going in right direction), what I am missing here is the exclusion of dead cells?).
| 1 | 2 |
antiox11040683_makarova
| 0 |
The Authors showed the role of the BCAT1 CXXC motif in AML and to understand how this may influence cellular redox processes.
| null | null |
The data presented by the authors are robust and interesting but are based on a single AML cell line, which is not a bonafide AML cell line (derived from the pleural effusion of a 37-year-old, White, male patient with histiocytic lymphoma, according to ATCC).
| 1 | 2 |
antiox11040683_makarova
| 0 |
At the beginning of the last paragraph of Introduction: "In this work, based on the design concept of improving the tensile stiffness of LET joints in Ref.
| null | null |
Transient analysis followed by reliability experiments/analysis/modeling of the proposed structure would be interesting and critical in aspect of joint application contrains. In my opoinion is should be added or explained in context of scheduled follow-up activities.
| 1 | 2 |
app12052642_perova
| 0 |
Chen, G.; Ma, F.; Hao, G.; Zhu, W. Modeling large deflections of initially curved beams in compliant mechanisms using 277 chained Beam-Constraint-Model, ASME J. Mech.
| null | null |
The article being evaluated is an extension of the above cited reference, and the authors would be well advised as to summarize this article, in part, and to delineate what has changed as of 2019, i.e. put this in a paragraph and to explain the subsequent evolution since 2019.
| 1 | 2 |
app12052642_perova
| 0 |
Author Response We thanks the reviewer for the encouragement and valuable comments.
| null | null |
Secondly what is missing in the article is in terms of application a clear delineation as to what benefits robotics accrue by the developments summarized in this article . What new capacities and abilities so created by this evolutionary jump Aside from that the article is solidly researched and is useful as a source of technology development
| 1 | 2 |
app12052642_perova
| 0 |
Author Response Thanks a lot for your encouragement and suggestion.
| null | null |
Keywords are not sufficient after the abstract.
| 1 | 2 |
app12052642_perova
| 0 |
Author Response Thanks a lot for your encouragement and suggestion.
| null | null |
Work relevant to the research topic is not incorporated, i.e., the work done by other researchers / authors in this field are not incorporated.
| 1 | 2 |
app12052642_perova
| 0 |
Author Response Thanks a lot for your encouragement and suggestion.
| null | null |
References are not written in the standard journal format.
| 1 | 2 |
app12052642_perova
| 0 |
10 + description) steady state inverstigation is acceptable.
| null | null |
Work relevant to the research topic is not incorporated, i.e., the work done by other researchers / authors in this field are not incorporated.
| 1 | 2 |
app12052642_perova
| 0 |
The flow of the paper or the organization of the paper has to be presented at the end of the introductory section.
| null | null |
Please add more details regarding paper’s novelty, it is not very clear what are the novelties of this paper.
| 1 | 2 |
app12052642_perova
| 0 |
The current paper proposes a novel lamina emergent torsional (LET) joint named double-laminated lamina emergent torsional joint (DL-LET) joint which utilizes a layer of flexible H18 aluminum foil to increase the tensile stiffness of LET joint.
| null | null |
Please add more details of how the theory from the first sections is applied in the results section and better detail the theoretical part, in this version the theoretical part is almost inexistent.
| 1 | 2 |
app12052642_perova
| 0 |
[19], this paper proposed a DL-LET joint by fixing a layer of flexible H18 aluminum foil a LET joint.
| null | null |
Please detail how the parameters were obtained.
| 1 | 2 |
app12052642_perova
| 0 |
Author Response Thanks a lot for your encouragement and suggestion.
| null | null |
The state of the art it is very poor regarding representative papers, maybe the author could add the following publications: o Hybrid Data-Driven Fuzzy Active Disturbance Rejection Control for Tower Crane Systems, European Journal of Control, vol. 58, pp. 373-387-11, 2021. o Event-Triggered Adaptive Fuzzy Control for Stochastic Nonlinear Systems with Unmeasured States and Unknown Backlash-Like Hysteresis, IEEE Transactions on Fuzzy Systems, doi 10.1109/TFUZZ.2020.2973950, pp. 1–19, 2020.
| 1 | 2 |
app12052642_perova
| 0 |
The flow of the paper or the organization of the paper has to be presented at the end of the introductory section.
| null | null |
Please add more details regarding the obtained results.
| 1 | 2 |
app12052642_perova
| 0 |
Nice piece of research but one aspect needs to be addressed.
| null | null |
Add the both the advantages and the disadvantages of the proposed method. In the proposed manuscript only the advantages are presented.
| 1 | 2 |
app12052642_perova
| 0 |
Author Response Thanks a lot for your encouragement and suggestion.
| null | null |
We agree that transient analysis is important in designing a robot joint. However, the transient analysis requires relevant parameters of the robot arm be determined besides the parameters of the joint. The following sentence has been added at the end of Conclusions: "For future work we will develop variable stiffness techniques of this joint, and explore its application in a robot arm considering both kinetostatic and transient behaviors"
| 2 | 1 |
app12052642_perova
| 0 |
Author Response We thanks the reviewer for the encouragement and valuable comments.
| null | null |
The following sentence has been added at the end of first paragraph of Conclusions to clarify disadvantage of DL-LET: “The DL-LET joint is vulnerable to delamination of the two layers.”
| 2 | 1 |
app12052642_perova
| 0 |
Following the referee’s suggestion we have added the reference to Mekhov’s paper.
| null | null |
Other examples of many-atom-cavity continuous observation papers: W. Niedenzu, S. Schütz, H. Habibian, G. Morigi, and H. Ritsch, Phys. Rev. 88, 033830 (2013). I. B. Mekhov and H. Ritsch, Phys. Rev. Lett. 102, 020403 (2009). J. F. Corney and G. J. Milburn, Phys. Rev. A 58, 2399 (1998). I. D. Leroux, M. H. Schleier-Smith, and V. Vuletić, Phys. Rev. Lett. 104, 073602 (2010).
| 1 | 2 |
atoms4010002_makarova
| 0 |
However, a change in the depth of a periodic potential does not change the Bloch frequency because this depends on the lattice’s spatial period, not the depth.
| null | null |
The role of sensing may in the end be less important and could be downplayed a bit in the manuscript.
| 1 | 2 |
atoms4010002_makarova
| 0 |
However, a change in the depth of a periodic potential does not change the Bloch frequency because this depends on the lattice’s spatial period, not the depth.
| null | null |
What is the role of excitations to higher Bloch bands?
| 1 | 2 |
atoms4010002_makarova
| 0 |
To be clear, other motional frequencies are altered: because the intracavity lattice depth is modulated by the backaction this will affect certain types of atomic motion, for example the oscillation frequency of an atom about the bottom of one of the potential minima \cite{Horak00}.
| null | null |
(1) It should be somehow mentioned more clearly (maybe in the abstract) that the idea is not completely new but work presents a new and more intutive picture of the system dynamics.
| 1 | 2 |
atoms4010002_makarova
| 0 |
Hence, in principle I consider it suitable for publication.
| null | null |
(2) It is very helpful to connect cavity output spectra and forces. To my knowledge this was first discussed in: Gangl, M., EPJD, 8(1), 29-40. This should be mentioned.
| 1 | 2 |
atoms4010002_makarova
| 0 |
Our work is very much still in progress and this paper will not, we hope, be our final word on this subject.
| null | null |
(3) The authors claim there should be no backaction of the field on the oscillation frequencies. This is somehow in contradiction with the eigenfrequency calculations (see Fig.4) in Horak, P.,Physical Review A, 61(3), 033609, 2000.
| 1 | 2 |
atoms4010002_makarova
| 0 |
This change in potential depth due to backaction is fully included in our treatment.
| null | null |
Also the BEC will lead to an effective change of the cavity length and lattice constant, which should renormalize the wavelength and thus om_recoil.
| 1 | 2 |
atoms4010002_makarova
| 0 |
This is because the presence of atoms in the cavity shifts the cavity resonance and hence the depth of the intracavity lattice: the Bloch energies are dependent on the potential depth.
| null | null |
(a) any measurement of the output field will generate backaction onto the condensate (Mekhov, J. Phys. B: Atomic, Molecular and Optical Physics, 45(10), 102001). This will generate extra noise, but might also help as it reduces atom number uncertainty in the cavity.
| 1 | 2 |
atoms4010002_makarova
| 0 |
This will generate extra noise, but might also help as it reduces atom number uncertainty in the cavity.
| null | null |
(b) There will be heating limiting the available measurement time.
| 1 | 2 |
atoms4010002_makarova
| 0 |
Rev. A 88, 033830 (2013). I. B. Mekhov and H. Ritsch, Phys. Rev. Lett. 102, 020403 (2009). J. F. Corney and G. J. Milburn, Phys. Rev. A 58, 2399 (1998). I. D. Leroux, M. H. Schleier-Smith, and V. Vuletić, Phys. Rev. Lett. 104, 073602 (2010).
| null | null |
There are other papers that link BECs, sensing and continuous quantum measurement process (in the absence of a cavity) M. Saba, T. A. Pasquini, C. Sanner, Y. Shin, W. Ketterle, and D. E. Pritchard, Science 307, 1945 (2005).
| 1 | 2 |
atoms4010002_perova
| 0 |
To my knowledge this was first discussed in: Gangl, M., EPJD, 8(1), 29-40.
| null | null |
The link to the sensing of weak forces (in this case gravity) is interesting, but I am not convinced whether this is a practical approach. The estimated accuracy is $10^6$ that does not sound great.
| 1 | 2 |
atoms4010002_perova
| 0 |
Also the BEC will lead to an effective change of the cavity length and lattice constant, which should renormalize the wavelength and thus om_recoil.
| null | null |
What is the role of excitations to higher Bloch bands?
| 1 | 2 |
atoms4010002_perova
| 0 |
Also the BEC will lead to an effective change of the cavity length and lattice constant, which should renormalize the wavelength and thus om_recoil.
| null | null |
Have the effects of radiation pressure forces, etc., taken into account?
| 1 | 2 |
atoms4010002_perova
| 0 |
Author Response The authors present a new interpretation to study Bloch oscillations in a cavity sustained optical lattice and the potential use of this system for very sensitive force measurement.The idea is closely related to previous work as Ref.
| null | null |
(1) It should be somehow mentioned more clearly (maybe in the abstract) that the idea is not completely new but work presents a new and more intutive picture of the system dynamics.
| 1 | 2 |
atoms4010002_perova
| 0 |
This will generate extra noise, but might also help as it reduces atom number uncertainty in the cavity.
| null | null |
(2) It is very helpful to connect cavity output spectra and forces. To my knowledge this was first discussed in: Gangl, M., EPJD, 8(1), 29-40. This should be mentioned.
| 1 | 2 |
atoms4010002_perova
| 0 |
(b) There will be heating limiting the available measurement time.
| null | null |
(3) The authors claim there should be no backaction of the field on the oscillation frequencies. Also the BEC will lead to an effective change of the cavity length and lattice constant, which should renormalize the wavelength and thus om_recoil. This is somehow in contradiction with the eigenfrequency calculations (see Fig.4) in Horak, P.,Physical Review A, 61(3), 033609, 2000.
| 1 | 2 |
atoms4010002_perova
| 0 |
This is somehow in contradiction with theeigenfrequency calculations (see Fig.4) in Horak, P.,Physical Review A, 61(3), 033609, 2000.
| null | null |
(b) There will be heating limiting the available measurement time. as the time scale can be faster than om_recoil, it could limit the measurement time to a fairly short period. Some rough estimate on the time scales should be added. In particular for the blue detuned case not only the average momentum but also the momentum spread will grow.
| 1 | 2 |
atoms4010002_perova
| 0 |
* The fact that as the incident energy increases, the TDCS decreases and shifts towards smaller ejection angles for positron impact is said twice between lines 108 and 115.
| null | null |
The authors did not mention this method for discussions in the manuscript. In earlier publications [Physics Reports 315 (1999) 409 and related references], a fully relativistic distorted-wave Born approximation (rDWBA) has been developed to describe the relativistic ionization processes.
| 1 | 2 |
atoms4010010_makarova
| 0 |
5 an 6 are mentioned but only 5 is discussed.
| null | null |
The RPWBA method in the manuscript should be compared with the previous rDWBA theory.
| 1 | 2 |
atoms4010010_makarova
| 0 |
This research field, concerning the three-body dynamics, is known to be a well-studied area.
| null | null |
Again in earlier publications [Physics Reports 315 (1999) 409 and related references], there are existing experiments of triple differential cross sections for relativistic K-shell ionization of Ag, Au, and so on. The authors did not mention these experimental works in the manuscript.
| 1 | 2 |
atoms4010010_makarova
| 0 |
* Line 40: "positrons" -> "positron" * Line 43: "positrons" -> "positron" and "ground state" -> "the ground state".
| null | null |
(ii) There are repeated Bibliography like ref. 11 and ref. 31.
| 1 | 2 |
atoms4010010_makarova
| 0 |
The work and discussion are very short, but still interesting.I recommend it for publication after the authors answer the questions and make the corrections described below:
| null | null |
In addition, I do believe that several figures could be combined in order to minimize journal space.
| 1 | 2 |
atoms4010010_makarova
| 0 |
In spite of the lack of any experimental, or, as is claimed, any theoretical, verification of this or any physical interpretation as to why this should occur even at very high velocities, I believe that work deserves publication since it should incite additional theoretical attempts to verify these predictions.
| null | null |
Page 9:* "experimental one" -> "experimental ones"
| 1 | 2 |
atoms4010010_makarova
| 0 |
Thank you for taking the time and energy to help us improve the paper.
| null | null |
The authors did not mention this method for discussions in the manuscript. The RPWBA method in the manuscript should be compared with the previous rDWBA theory. At least the authors should mention the differences of the two methods and how far the RPWBA can be compared to rDWBA? In earlier publications [Physics Reports 315 (1999) 409 and related references], a fully relativistic distorted-wave Born approximation (rDWBA) has been developed to describe the relativistic ionization processes.
| 1 | 2 |
atoms4010010_perova
| 0 |
Maybe the authors could use "is related to the probability" or something like that.
| null | null |
Again in earlier publications [Physics Reports 315 (1999) 409 and related references], there are existing experiments of triple differential cross sections for relativistic K-shell ionization of Ag, Au, and so on. The authors did not mention these experimental works in the manuscript. It would be nice if the RPWBA method in the manuscript can be compared with the experiments.
| 1 | 2 |
atoms4010010_perova
| 0 |
I find no major problems with the manuscript, either in content or presentation.
| null | null |
The authors have not carefully proofread this manuscript. Evidences of this includes (i) some errors in English typing, e.g. line 27 and line 119: it should be ‘plane wave …’ instead of ‘plan wave …’. Line between 33 and 34: it should be ‘The scattered positron and ejected electron …’ instead of ‘The scattered electron and ejected positron …’. (ii) There are repeated Bibliography like ref. 11 and ref. 31.
| 1 | 2 |
atoms4010010_perova
| 0 |
* Line 19: "Coulomb system" -> "Coulomb systems"
| null | null |
In addition, I do believe that several figures could be combined in order to minimize journal space.
| 1 | 2 |
atoms4010010_perova
| 0 |
------------------------------------------- Page 2: * Line 36: "describes the probability": actually it is the flux ratio, and it could be divergent in some cases.
| null | null |
Page 9:* "experimental one" -> "experimental ones"
| 1 | 2 |
atoms4010010_perova
| 0 |
Author response We would like to thank the referee for his/her careful reading of the manuscript and the helpful comments.
| null | null |
The first example is the result announced in Equation (4), concerning the phase shift due to the gravity gradient gamma. This effect was first calculated by Wolf and Tourrencin Physics Letters A 251 (1999) pp 241–246 and discussed with more details in A. Peters, K.Y. Chung and S. Chu, Metrologia 2001, 38, 25–61.
| 1 | 2 |
atoms4020014_perova
| 0 |
I recommend accepting this manuscript, provided the following points are clarified:
| null | null |
Moreover, the authors call this effect a quantum correction probably because it is proportional to hbar but it would be more clear to explain that, the leading term of the gravitation phase being independent of hbar because of a cancellation (hbar appears in the numerator and denominator of the quantity giving the phase), the term linear in gamma is also proportional to the recoil velocity which itself is proportional to hbar.
| 1 | 2 |
atoms4020014_perova
| 0 |
The results obtained seem reasonable, although I have no time to verify all the derivations.
| null | null |
A second example is the equation 9b for Wigner function: the associated quotation is ref. 17 by one of the authors and M.A. Kasevich in Phys Rev A (2006). A brief search on the web proves that a similar equation was used by Hongyi Fan Phys Rev A 656, 064102 (2002) who quotes two references dating from 1984 and a book published in 1994. I am not sufficiently aware of the use f Wigner function but I am sure that there are better and more useful references to quote in addition to ref 17!
| 1 | 2 |
atoms4020014_perova
| 0 |
The response to these comments and changes to the manuscript in response to these comments is given below: 1.
| null | null |
A second example is the equation 9b for Wigner function: the associated quotation is ref. 17 by one of the authors and M.A. Kasevich in Phys Rev A (2006). A brief search on the web proves that a similar equation was used by Hongyi Fan Phys Rev A 656, 064102 (2002) who quotes two references dating from 1984 and a book published in 1994. I am not sufficiently aware of the use f Wigner function but I am sure that there are better and more useful references to quote in addition to ref 17!
| 1 | 2 |
atoms4020014_perova
| 0 |
The response to these comments and changes to the manuscript in response to these comments is given below: 1.
| null | null |
In my opinion, phi_Q is the real quantum correction due to the spreading of the wavepacket during propagation. If I am correct, this should be explained.
| 1 | 2 |
atoms4020014_perova
| 0 |
The correction phi_Q was not discussed in the previous papers I know on the subject and I think that the paper must be published but, as explained below, important improvements are needed.
| null | null |
The meaning of the three x_C, x_qC and x_QC (Equation (99)) is far from obvious but it is very surprising that the leading term in T^2 is different?
| 1 | 2 |
atoms4020014_perova
| 0 |
The treatment involves quantum corrections which are treated by calculating the Wigner representation of the density matrix and I am not aware of the use of such an extensive use of Wigner representation to describe atom interferometry experiments.
| null | null |
The paper contains only one figure with 28 panels presenting the results of the calculations. I think that this figure is very difficult to read! I do not understand clearly why results are plotted with y < y_min if this not physical: please explain!
| 1 | 2 |
atoms4020014_perova
| 0 |
I recommend accepting this manuscript, provided the following points are clarified:
| null | null |
The paper contains only one figure with 28 panels presenting the results of the calculations. I think that this figure is very difficult to read! I do not understand clearly why results are plotted with y < y_min if this not physical: please explain!
| 1 | 2 |
atoms4020014_perova
| 0 |
Authors’ response We would like to thank the referee for his/her careful reading of the manuscript and the helpful comments.
| null | null |
A figure explaining the geometry of the experiment would also help.
| 1 | 2 |
atoms4020014_perova
| 0 |
1 Review Report 1 Originality/Novelty This paper treats an important question concerning the measurement of the gravitational constant G by atom interferometry.
| null | null |
The process is calculated as if the gravitational forces can be neglected during the diffraction laser pulses. This is probably an excellent approximation but please comment it!
| 1 | 2 |
atoms4020014_perova
| 0 |
The results obtained seem reasonable, although I have no time to verify all the derivations.
| null | null |
The fountain is assumed to be exactly symmetric (see line after Equation (100)). It is well known that with symmetric fountains diffraction with retro-reflected laser beams produces stray interferometers... Minor Remarks
| 1 | 2 |
atoms4020014_perova
| 0 |
Two processes are considered, one occurs during the interaction between the cold atom cloud and the Raman beams, the other occurs during the free evolution of the cold atom cloud in vacuum.
| null | null |
I noted an error after Equation (1): ... the gravitational potential is constant... I assume that the authors meant acceleration g, not the potential.
| 1 | 2 |
atoms4020014_perova
| 0 |
I recommend accepting this manuscript, provided the following points are clarified:
| null | null |
The paper is quite difficult to read, because of very many bulky equations. I do not see how to reduce the number of equations but I think that some more comments would help the reader.
| 1 | 2 |
atoms4020014_perova
| 0 |
Authors’ response We would like to thank the referee for his/her careful reading of the manuscript and the helpful comments.
| null | null |
The relative location of the test mass to the cold atom cloud should be clearly stated during the calculation, as the gravitational force is a vector. If the test mass is not located in the direction of the evolution trajectory of the atom cloud, the applicability of some formulas (e.g. Equation (3)) need to be verified. It will be helpful to the readers if a figure is provided to show the locations.
| 1 | 2 |
atoms4020014_perova
| 0 |
These results are interesting to the people working in the field of atom interferometer, because the test mass are often used in the practical experiment.
| null | null |
The cloud is assumed to be characterized by a Wigner distribution function. What are the advantages to use Wigner distribution function instead of wave function?
| 1 | 2 |
atoms4020014_perova
| 0 |
These results are interesting to the people working in the field of atom interferometer, because the test mass are often used in the practical experiment.
| null | null |
In the Introduction, quite a lot of papers are cited concerning the applications of atom interferometer in varies fields. Just for the note of the authors, there are some new applications of atom interferometer, e.g., in the accurate measurement of the quadratic Zeeman coefficient [J. Phys. B: At. Mol. Opt. Phys., 47(1): 015001, 2014].
| 1 | 2 |
atoms4020014_perova
| 0 |
This EPS was carefully purified according to standard purification protocols for EPS.
| null | null |
The manuscript is very long: it contains a lot of information and many references not always pertinent to EPS characterization.
| 1 | 2 |
biom12060834_makarova
| 0 |
The studied EPS showed promising properties to use in the food industry.
| null | null |
Optimization of production constitutes an important part not mentioned in the title.
| 1 | 2 |
biom12060834_makarova
| 0 |
Comment 15: l. 169-170: “thirty” instead of “thirteen”?
| null | null |
Acceptability for food applications was not discussed.
| 1 | 2 |
biom12060834_makarova
| 0 |
Also, β-glucopyranose and β-galactopyranose structures were identified and the acetylation was confirmed.
| null | null |
Articles (mostly definite, but also indefinite) are often missing and sometimes superfluous.
| 1 | 2 |
biom12060834_makarova
| 0 |
Response 2: Dear reviewer, thanks for your valuable comments for improving the quality of this paper.
| null | null |
EPS vs. EPSs in plural form should be consistent throughout.
| 1 | 2 |
biom12060834_makarova
| 0 |
If the authors do not add methylation analysis and perform full NMR spectral analysis, the claims about structure determination should be removed from the manuscript.
| null | null |
Use a consistent abbreviation (l or L) for liter (including milliliter and microliter) throughout.
| 1 | 2 |
biom12060834_makarova
| 0 |
433, 434, 454, 458, and 507 : First section 3.6 (and its subsections) should be section 3.5.
| null | null |
l. 160 There is no coded value in Table 1.
| 1 | 2 |
biom12060834_makarova
| 0 |
Based on the 1H NMR spectrum, the purity and/or heterogeneity of the EPS is questioned.
| null | null |
l. 165 Table 2 where Table 1 expected
| 1 | 2 |
biom12060834_makarova
| 0 |
The following comments were not addressed correctly:
| null | null |
l. 169-170 thirty instead of thirteen ?
| 1 | 2 |
biom12060834_makarova
| 0 |
Comment 22: Figure 1: What is the significance of the tick mark labels on the maps?
| null | null |
l. 177 i instead of 0 in second term?
| 1 | 2 |
biom12060834_makarova
| 0 |
Comment 4: Acceptability for food applications was not discussed.
| null | null |
l. 228 GPC defined on l. 231
| 1 | 2 |
biom12060834_makarova
| 0 |
Units are not specified on the axes labels or in the legend.
| null | null |
l. 230 PEG undefined
| 1 | 2 |
biom12060834_makarova
| 0 |
Answer 25: Suggestion has been included in the revised version of the manuscript Comment 26: Figure 3: Units are not specified on the axes labels or in the legend.
| null | null |
l. 247 Volume of 0.2 mM ethanolic DPPH solution?
| 1 | 2 |
biom12060834_makarova
| 0 |
The evidences for the partial structure given are not convincing.
| null | null |
255, 286, and 441 et al.
| 1 | 2 |
biom12060834_makarova
| 0 |
Comment 2: The manuscript is very long: it contains a lot of information and many references not always pertinent to EPS characterization.
| null | null |
Figure 1 What is the significance of the tick mark labels on the maps? Are these maps really necessary?
| 1 | 2 |
biom12060834_makarova
| 0 |
Comment 28: Figure 4; This figure is redundant as it gives the same information as Figure 3.
| null | null |
Figure 2 No x-axis label Units not specified
| 1 | 2 |
biom12060834_makarova
| 0 |
Answer 1: To better understand EPS chemical structure, further 2D NMR experiments were performed and results are presented inside the manuscript.
| null | null |
Figure 3
| 1 | 2 |
biom12060834_makarova
| 0 |
Comment 22: Figure 1: What is the significance of the tick mark labels on the maps?
| null | null |
417 and 432 30.0 instead of 3.0 ?
| 1 | 2 |
biom12060834_makarova
| 0 |
Comment 27: l. 414, Delete “(“before “C. pH”. ll. 416 and 432 , Add “C.” before “pH=” . ll. 417 and 432 , “30.0” instead of “3.0” ?
| null | null |
Units are not specified on the axes labels or in the legend. Figure 4 This figure is redundant as it gives the same information as Figure 3. Tick label values for glucose and yeast extract are different.
| 1 | 2 |
biom12060834_makarova
| 0 |
Comment 34: The abbreviation for glucose is Glc.
| null | null |
433, 434, 454, 458, and 507 First section 3.6 (and its subsections) should be section 3.5.
| 1 | 2 |
biom12060834_makarova
| 0 |
Fourier transform infrared spectroscopy (FTIR) and NMR spectroscopy data can only be regarded as preliminary.
| null | null |
l. 471, 600, 678, and 718 Reference format is different; corresponding references could be missing in the list.
| 1 | 2 |
biom12060834_makarova
| 0 |
According to the 1H NMR spectrum, it can be assumed that EPS has a complex branched structure.
| null | null |
l. 480 Why was linkage analysis not performed?
| 1 | 2 |
biom12060834_makarova
| 0 |
This allows us to conclude they are different polysaccharides.
| null | null |
Figure 6 Bacterial EPSs are normally composed of repeating units. How can the authors ascertain that mannose does not come from mannans in yeast extract? A 2D COSY spectrum would be necessary to confirm the assignments made on the 1D: e.g., H2- Man is not normally found in the range 3.2-3.5 ppm (the statement ll. 495-496 is wrong). The abbreviation for glucose is Glc.
| 1 | 2 |
biom12060834_makarova
| 0 |
(I was referring to the chemical method by methylation.)
| null | null |
Figure 6 Bacterial EPSs are normally composed of repeating units. How can the authors ascertain that mannose does not come from mannans in yeast extract? A 2D COSY spectrum would be necessary to confirm the assignments made on the 1D: e.g., H2- Man is not normally found in the range 3.2-3.5 ppm (the statement ll. 495-496 is wrong). The abbreviation for glucose is Glc.
| 1 | 2 |
biom12060834_makarova
| 0 |
Comment 42: l. 683-684: Food-grade oils are not aliphatic and aromatic hydrocarbons.
| null | null |
Figure 6 Bacterial EPSs are normally composed of repeating units. How can the authors ascertain that mannose does not come from mannans in yeast extract? A 2D COSY spectrum would be necessary to confirm the assignments made on the 1D: e.g., H2- Man is not normally found in the range 3.2-3.5 ppm (the statement ll. 495-496 is wrong). The abbreviation for glucose is Glc.
| 1 | 2 |
biom12060834_makarova
| 0 |
According to Figure 7. the activity of the ascorbic acid is higher than the activity of EPS produced by CamB6.
| null | null |
Figure 6 Bacterial EPSs are normally composed of repeating units. How can the authors ascertain that mannose does not come from mannans in yeast extract? A 2D COSY spectrum would be necessary to confirm the assignments made on the 1D: e.g., H2- Man is not normally found in the range 3.2-3.5 ppm (the statement ll. 495-496 is wrong). The abbreviation for glucose is Glc.
| 1 | 2 |
biom12060834_makarova
| 0 |
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