question
stringlengths 1
270
| answer
stringlengths 1
29k
| __index_level_0__
int64 1
120k
|
|---|---|---|
What group ultimately sponsored the Tuvalu water resources policy? | Global Environment Fund | 81,317 |
How long has this name immutability been guaranteed? | since Unicode version 2.0 | 59,494 |
What is one type of capacitor that has a specified rating value for maximum ripple current? | aluminum electrolytic capacitors | 53,682 |
What is (are) Diabetes Type 2 ? | Diabetes means your blood glucose, or blood sugar, levels are too high. With type 2 diabetes, the more common type, your body does not make or use insulin well. Insulin is a hormone that helps glucose get into your cells to give them energy. Without insulin, too much glucose stays in your blood. Over time, high blood glucose can lead to serious problems with your heart, eyes, kidneys, nerves, and gums and teeth. You have a higher risk of type 2 diabetes if you are older, obese, have a family history of diabetes, or do not exercise. Having prediabetes also increases your risk. Prediabetes means that your blood sugar is higher than normal but not high enough to be called diabetes. The symptoms of type 2 diabetes appear slowly. Some people do not notice symptoms at all. The symptoms can include - Being very thirsty - Urinating often - Feeling very hungry or tired - Losing weight without trying - Having sores that heal slowly - Having blurry eyesight Blood tests can show if you have diabetes. One type of test, the A1C, can also check on how you are managing your diabetes. Many people can manage their diabetes through healthy eating, physical activity, and blood glucose testing. Some people also need to take diabetes medicines. NIH: National Institute of Diabetes and Digestive and Kidney Diseases | 92,234 |
Where did Victoria often go for holiday? | mainland Europe | 37,441 |
Why has there been a several court cases against Sky and Premier League? | The TV rights agreement between the Premier League and Sky has faced accusations of being a cartel | 77,709 |
Who organized the Spanish expedition? | Bruno Mauricio de Zabala | 39,764 |
Kakar argued that the definition should include any group defined by the perpetrator and which other group? | political groups | 1,252 |
The Erector Square complex is a gallery that is located where? | Fair Haven neighborhood houses | 44,238 |
What types of services will be offered by the BeiDou system? | a free service to civilians and licensed service to the Chinese government and military | 15,254 |
What type of countries did Tito develop relations with? | developing | 19,758 |
Local Southampton football leagues have what day of the week in their names? | Sunday | 19,198 |
When did Aryabhata live? | 476-550 | 53,871 |
what research (or clinical trials) is being done for Dandy-Walker Syndrome ? | The mission of the National Institute of Neurological Disorders and Stroke (NINDS) is to seek fundamental knowledge about the brain and nervous system, and to use that knowledge to reduce the burden of neurological disease. The NINDS conducts and supports a wide range of studies that explore the complex mechanisms of normal brain development. Researchers are studying DNA samples from individuals with Dandy-Walker syndrome to identify genes involved with the syndrome, as well as to better understand its causes and improve diagnosis and treatment options. Other research indicates that mothers with diabetes and those with rubella (German measles) during pregnancy are more likely to have a child with Dandy-Walker syndrome. | 88,464 |
How long did the Indian influence date back to for the Malay-speaking world? | 3rd century BCE | 42,808 |
What person recieved a seven year transportation sentence for striking Victoria on the head with his cane? | Robert Pate | 37,626 |
Who is responsible for the growing pride in Brazilian communities? | black and indigenous communities. | 24,285 |
Is core binding factor acute myeloid leukemia inherited ? | CBF-AML is not inherited but arises from genetic rearrangements in the body's cells that occur after conception. | 106,884 |
This reference also holds significance as what the the Grecian people ? | motto of the Greek War of Independence | 73,963 |
What is (are) Periventricular Leukomalacia ? | Periventricular leukomalacia (PVL) is characterized by the death of the white matter of the brain due to softening of the brain tissue. It can affect fetuses or newborns; premature babies are at the greatest risk of the disorder. PVL is caused by a lack of oxygen or blood flow to the periventricular area of the brain, which results in the death or loss of brain tissue. The periventricular area-the area around the spaces in the brain called ventricles-contains nerve fibers that carry messages from the brain to the body's muscles. Although babies with PVL generally have no outward signs or symptoms of the disorder, they are at risk for motor disorders, delayed mental development, coordination problems, and vision and hearing impairments. PVL may be accompanied by a hemorrhage or bleeding in the periventricular-intraventricular area (the area around and inside the ventricles), and can lead to cerebral palsy. The disorder is diagnosed by ultrasound of the head. | 115,765 |
What kind of rules does a poly-sided match usually have? | no holds barred rules | 42,944 |
When mixed wit clay, what is bitumen called? | asphaltum | 37,131 |
When did Apple begin shipping computers with CD-RW drives? | early 2001 | 32,049 |
What are the genetic changes related to childhood myocerebrohepatopathy spectrum ? | MCHS is caused by mutations in the POLG gene. This gene provides instructions for making one part, the alpha subunit, of a protein called polymerase gamma (pol ). Pol functions in mitochondria, which are structures within cells that use oxygen to convert the energy from food into a form cells can use. Mitochondria each contain a small amount of DNA, known as mitochondrial DNA (mtDNA), which is essential for the normal function of these structures. Pol "reads" sequences of mtDNA and uses them as templates to produce new copies of mtDNA in a process called DNA replication. Most POLG gene mutations change single protein building blocks (amino acids) in the alpha subunit of pol . These changes result in a mutated pol that has a reduced ability to replicate DNA. Although the mechanism is unknown, mutations in the POLG gene often result in fewer copies of mtDNA (mtDNA depletion), particularly in muscle, brain, or liver cells. MtDNA depletion causes a decrease in cellular energy, which could account for the signs and symptoms of MCHS. | 94,074 |
What trades did the Pitcairners establish while on Norfolk Island? | farming and whaling industries | 49,922 |
What episode of South Park dealt with wrestling? | "W.T.F." | 43,125 |
What Newtonian concept can be used in the formulation of an idea for the synchronization of clocks? | concept of "relative, apparent, and common time" | 61,877 |
What has the UK political system functioned as? | a two-party (sometimes called a "two-and-a-half party") system | 58,017 |
What is (are) Multifocal Motor Neuropathy ? | Multifocal motor neuropathy is a progressive muscle disorder characterized by muscle weakness in the hands, with differences from one side of the body to the other in the specific muscles involved. It affects men much more than women. Symptoms also include muscle wasting, cramping, and involuntary contractions or twitching of the leg muscles. The disorder is sometimes mistaken for amyotrophic laterial sclerosis (ALS, or Lou Gehrig's disease) but unlike ALS, it is treatable. An early and accurate diagnosis allows patients to recover quickly. | 114,937 |
What is created when vocal folds are slightly closed and vibrate? | voiced consonants | 14,489 |
Which season five contestant has had the most success after the show? | Chris Daughtry | 7,239 |
What are the symptoms of Nonbullous congenital ichthyosiform erythroderma ? | What are the signs and symptoms of Nonbullous congenital ichthyosiform erythroderma? The Human Phenotype Ontology provides the following list of signs and symptoms for Nonbullous congenital ichthyosiform erythroderma. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Hypohidrosis 90% Ectropion 5% Short finger 5% Short toe 5% Small nail 5% Thin nail 5% Abnormality of the hair - Autosomal recessive inheritance - Congenital ichthyosiform erythroderma - Congenital nonbullous ichthyosiform erythroderma - External genital hypoplasia - Growth delay - Intellectual disability - Palmoplantar keratoderma - Paralysis - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common. | 112,734 |
Is a child who excercies likely to perform better in school? | The effects of exercise on memory have important implications for improving children's academic performance | 36,187 |
What is (are) Stroke ? | A stroke occurs if the flow of oxygen-rich blood to a portion of the brain is blocked. Without oxygen, brain cells start to die after a few minutes. Sudden bleeding in the brain also can cause a stroke if it damages brain cells.
If brain cells die or are damaged because of a stroke, symptoms occur in the parts of the body that these brain cells control. Examples of stroke symptoms include sudden weakness; paralysis or numbness of the face, arms, or legs (paralysis is an inability to move); trouble speaking or understanding speech; and trouble seeing.
A stroke is a serious medical condition that requires emergency care. A stroke can cause lasting brain damage, long-term disability, or even death.
If you think you or someone else is having a stroke, call 911 right away. Do not drive to the hospital or let someone else drive you. Call an ambulance so that medical personnel can begin life-saving treatment on the way to the emergency room. During a stroke, every minute counts.
Overview
The two main types of stroke are ischemic (is-KE-mik) and hemorrhagic (hem-ah-RAJ-ik). Ischemic is the more common type of stroke.
An ischemic stroke occurs if an artery that supplies oxygen-rich blood to the brain becomes blocked. Blood clots often cause the blockages that lead to ischemic strokes.
A hemorrhagic stroke occurs if an artery in the brain leaks blood or ruptures (breaks open). The pressure from the leaked blood damages brain cells. High blood pressure and aneurysms (AN-u-risms) are examples of conditions that can cause hemorrhagic strokes. (Aneurysms are balloon-like bulges in an artery that can stretch and burst.)
Another condition thats similar to a stroke is a transient ischemic attack, also called a TIA or mini-stroke. A TIA occurs if blood flow to a portion of the brain is blocked only for a short time. Thus, damage to the brain cells isnt permanent (lasting).
Like ischemic strokes, TIAs often are caused by blood clots. Although TIAs are not full-blown strokes, they greatly increase the risk of having a stroke. If you have a TIA, its important for your doctor to find the cause so you can take steps to prevent a stroke.
Both strokes and TIAs require emergency care.
Outlook
Stroke is a leading cause of death in the United States. Many factors can raise your risk of having a stroke. Talk with your doctor about how you can control these risk factors and help prevent a stroke.
If you have a stroke, prompt treatment can reduce damage to your brain and help you avoid lasting disabilities. Prompt treatment also may help prevent another stroke.
Researchers continue to study the causes and risk factors for stroke. Theyre also finding new and better treatments and new ways to help the brain repair itself after a stroke. | 92,193 |
Is congenital plasminogen deficiency inherited ? | This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition. | 108,319 |
What is (are) Amyloidosis and Kidney Disease ? | You and your doctor will work together to choose a treatment that's best for you. The publications of the NIDDK Kidney Failure Series can help you learn about the specific issues you will face.
Booklets
- What I need to know about Kidney Failure and How its Treated - Treatment Methods for Kidney Failure: Hemodialysis - Treatment Methods for Kidney Failure: Peritoneal Dialysis - Treatment Methods for Kidney Failure: Kidney Transplantation - Kidney Failure: Eat Right to Feel Right on Hemodialysis
Fact Sheets
- Kidney Failure: What to Expect - Vascular Access for Hemodialysis - Hemodialysis Dose and Adequacy - Peritoneal Dialysis Dose and Adequacy - Amyloidosis and Kidney Disease - Anemia in Chronic Kidney Disease - Chronic Kidney Disease-Mineral and Bone Disorder - Financial Help for Treatment of Kidney Failure
Learning as much as you can about your treatment will help make you an important member of your health care team.
This content is provided as a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. The NIDDK translates and disseminates research findings through its clearinghouses and education programs to increase knowledge and understanding about health and disease among patients, health professionals, and the public. Content produced by the NIDDK is carefully reviewed by NIDDK scientists and other experts.
The NIDDK would like to thank: Glenn Chertow, M.D., University of California at San Francisco; William J. Stone, M.D., Vanderbilt University; Morie A. Gertz, M.D., Mayo Clinic
This information is not copyrighted. The NIDDK encourages people to share this content freely.
September 2014 | 119,832 |
To whom did Queen Victoria dedicate a memorial after his death for grateful service? | Disraeli | 37,744 |
Which North American version of football calls for 12 player per side on the field? | Canadian | 70,080 |
What brought a change in vocabulary? | The Crimean War | 21,949 |
Canada's Supreme Court didn't actually become that country's highest court until when? | 1949 | 57,091 |
What are Nanjing people called by others? | 'Nanjing big radish' | 17,100 |
What does Kitab al-shifa mean? | Book of Healing | 53,932 |
How many were ruled to be redrawn in 2015 | lawmakers had followed an illegal and unconstitutional process overly influenced by party operatives, and ruled that at least eight districts had to be redrawn | 45,106 |
What is the percentage of asexuals? | 1%. | 34,816 |
Where did most of the great literary figures of the Hellenistic period study? | Alexandria | 38,765 |
On what date did the Soviet Union dissolve? | December 26, 1991 | 56,397 |
What are the symptoms of Jones syndrome ? | What are the signs and symptoms of Jones syndrome? Jones syndrome is primarily characterized by gingival fibromatosis (slowly progressive enlargement of the gums) and progressive, sensorineural hearing loss. Enlargement of the gingival tissue usually begins at the time the permanent teeth are erupting, although it may occur before. Excessive growth of the gums may cause displacement of teeth, over-retention of primary teeth, increased spacing, speech problems, and painful chewing. Absence of teeth (oligodontia) and extra (supernumerary) teeth have also been reported in people with Jones syndrome. Hearing loss has been reported to begin in the second or third decade of life and is bilateral (in both ears). Overlapping of symptoms with other syndromes associated with hereditary gingival fibromatosis (HGF) has been reported, including Zimmermann-Laband syndrome and gingival fibromatosis-hypertrichosis syndrome (HGF with excessive hair growth). It has been proposed that the overlapping features reported may represent a spectrum of a single disorder, rather than separate syndromes. The Human Phenotype Ontology provides the following list of signs and symptoms for Jones syndrome. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Delayed eruption of teeth 90% Gingival overgrowth 90% Sensorineural hearing impairment 90% Autosomal dominant inheritance - Gingival fibromatosis - Progressive sensorineural hearing impairment - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common. | 113,748 |
Why did Laemmle change his position on "unclean pictures"? | Universal was losing money | 13,456 |
In 1938 what was von Neumann awarded? | Bôcher Memorial Prize | 53,330 |
What was the movie made to inspire assembly line workers called? | The Gun | 32,201 |
What did Peck's widow call Lee? | a national treasure | 4,809 |
What type of buildings were took the most effort to build? | abbeys and cathedrals. | 10,916 |
What was the name of the first Cathedral? | Dulce Nombre de Maria | 69,172 |
What does chansons de geste mean in English? | songs of great deeds | 23,524 |
When did Giotto die? | 1337 | 23,574 |
What country did Cardinal Eduardo Francisco Pironi represent? | Argentina | 50,612 |
When was the movie Airport made? | 1970 | 80,642 |
What are the genetic changes related to Aicardi syndrome ? | The cause of Aicardi syndrome is unknown. Because it occurs almost exclusively in females, researchers believe that it is probably the result of a mutation in a gene on the X chromosome. People normally have 46 chromosomes in each cell. Two of the 46 chromosomes, known as X and Y, are called sex chromosomes because they help determine whether a person will develop male or female sex characteristics. Genes on these chromosomes are also involved in other functions in the body. Females typically have two X chromosomes (46,XX), and males have one X chromosome and one Y chromosome (46,XY). Early in embryonic development in females, one of the two X chromosomes is permanently inactivated in somatic cells (cells other than egg and sperm cells). X-inactivation ensures that females, like males, have only one active copy of the X chromosome in each body cell. Usually X-inactivation occurs randomly, so that each X chromosome is active in about half the body's cells. Sometimes X-inactivation is not random, and one X chromosome is active in more than half of cells. When X-inactivation does not occur randomly, it is called skewed X-inactivation. Skewed X-inactivation sometimes occurs when there is a severe gene mutation in one of the X chromosomes in each cell. Because the cells where this chromosome is active will not be able to survive as well, X-inactivation will appear to be skewed. Skewed X-inactivation has been identified in girls with Aicardi syndrome, further supporting the idea that the disorder is caused by a mutation in a gene on the X chromosome. However, this gene has not been identified, and it is unknown how the genetic change that causes Aicardi syndrome results in the various signs and symptoms of this disorder. | 104,293 |
What are the heads of government in Wales, Scotland and Northern Ireland called? | First Minister | 9,860 |
What is (are) Farber lipogranulomatosis ? | Farber lipogranulomatosis is a rare inherited condition involving the breakdown and use of fats in the body (lipid metabolism). In affected individuals, lipids accumulate abnormally in cells and tissues throughout the body, particularly around the joints. Three classic signs occur in Farber lipogranulomatosis: a hoarse voice or a weak cry, small lumps of fat under the skin and in other tissues (lipogranulomas), and swollen and painful joints. Affected individuals may also have difficulty breathing, an enlarged liver and spleen (hepatosplenomegaly), and developmental delay. Researchers have described seven types of Farber lipogranulomatosis based on their characteristic features. Type 1 is the most common, or classical, form of this condition and is associated with the classic signs of voice, skin, and joint problems that begin a few months after birth. Developmental delay and lung disease also commonly occur. Infants born with type 1 Farber lipogranulomatosis usually survive only into early childhood. Types 2 and 3 generally have less severe signs and symptoms than the other types. Affected individuals have the three classic signs and usually do not have developmental delay. Children with these types of Farber lipogranulomatosis typically live into mid- to late childhood. Types 4 and 5 are associated with severe neurological problems. Type 4 usually causes life-threatening health problems beginning in infancy due to massive lipid deposits in the liver, spleen, lungs, and immune system tissues. Children with this type typically do not survive past their first year of life. Type 5 is characterized by progressive decline in brain and spinal cord (central nervous system) function, which causes paralysis of the arms and legs (quadriplegia), seizures, loss of speech, involuntary muscle jerks (myoclonus), and developmental delay. Children with type 5 Farber lipogranulomatosis survive into early childhood. Types 6 and 7 are very rare, and affected individuals have other associated disorders in addition to Farber lipogranulomatosis. | 98,142 |
According to English Chief Justice Sir Edward Coke, what should Kings follow? | God and the law | 60,100 |
Classical music is rooted in what kind of tradition? | Western music | 18,384 |
What label for the Greek market were artists on under the Sony umbrella? | Feelgood Records | 12,763 |
What dinosaur spread to every continent? | Iguanodon | 29,189 |
What part of the life cycle of moths does Bt toxin effect? | larvae | 47,926 |
When was the tungsten filament introduced? | 1906 | 40,943 |
Beyonce's first solo album in the U.S. with what artist in the lead single? | Jay Z | 404 |
Who did Beyonce star with in the movie, "Austin Powers in Goldmember"? | Mike Myers | 384 |
What concepts overlook the experiential nature of basic elements? | quality", "matter", and "form" | 8,702 |
What are the treatments for autoimmune lymphoproliferative syndrome ? | These resources address the diagnosis or management of ALPS: - Gene Review: Gene Review: Autoimmune Lymphoproliferative Syndrome - Genetic Testing Registry: Autoimmune lymphoproliferative syndrome - Genetic Testing Registry: Autoimmune lymphoproliferative syndrome type 1, autosomal recessive - Genetic Testing Registry: Autoimmune lymphoproliferative syndrome, type 1a - Genetic Testing Registry: Autoimmune lymphoproliferative syndrome, type 1b - Genetic Testing Registry: Autoimmune lymphoproliferative syndrome, type 2 - Genetic Testing Registry: RAS-associated autoimmune leukoproliferative disorder - National Institute of Allergy and Infectious Diseases (NIAID): ALPS Treatment These resources from MedlinePlus offer information about the diagnosis and management of various health conditions: - Diagnostic Tests - Drug Therapy - Surgery and Rehabilitation - Genetic Counseling - Palliative Care | 105,570 |
How many people did the company employ in 1943? | 44,000 | 75,880 |
What kinds of groups around the world can benefit from the Community Tool Box? | professionals and grassroots groups engaged in the work of community health and development | 18,017 |
Who granted the privilege of Piotrkow? | King John I Albert | 20,384 |
What song did the comedy Desperately Seeking Susan promote? | "Into the Groove" | 46,540 |
How much of Pakistan's small-scale manufacturing is in Punjab? | 70% | 86,704 |
The Holiday Festival of Lights are held where? | James Island County Park | 72,474 |
Which original judge was a choreographer? | Paula Abdul | 6,970 |
WHo was first invloved in the polonization? | the highest members of the nobility | 20,309 |
What defines finite groups of order p, a prime number, as being necessarily cyclic (abelian) groups Zp? | Lagrange's theorem | 62,680 |
As of 2010, what percentage made up white people in NYC? | 44 | 4,158 |
What did Sir William Thomson's tide-predicting machine use to function? | system of pulleys and wires | 23,833 |
The name "ApocalyPS3" combines "PS3" with what other word? | apocalypse | 62,292 |
What are the symptoms of Hereditary vascular retinopathy ? | What are the signs and symptoms of Hereditary vascular retinopathy? The Human Phenotype Ontology provides the following list of signs and symptoms for Hereditary vascular retinopathy. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Abnormality of the retinal vasculature 90% Visual impairment 90% Abnormality of movement 50% Behavioral abnormality 50% Cerebral ischemia 50% Developmental regression 50% Hematuria 50% Hemiplegia/hemiparesis 50% Migraine 50% Nephropathy 50% Neurological speech impairment 50% Proteinuria 50% Retinopathy 50% Seizures 50% Cataract 7.5% Glaucoma 7.5% Incoordination 7.5% Micronodular cirrhosis 5% Abnormality of the musculature of the lower limbs - Abnormality of the periventricular white matter - Adult onset - Apraxia - Autosomal dominant inheritance - Central nervous system degeneration - Dementia - Dysarthria - Elevated erythrocyte sedimentation rate - Elevated hepatic transaminases - Hemiparesis - Limb pain - Lower limb hyperreflexia - Macular edema - Pigmentary retinal degeneration - Progressive - Progressive forgetfulness - Progressive visual loss - Punctate vasculitis skin lesions - Retinal exudate - Retinal hemorrhage - Stroke - Telangiectasia - Vasculitis in the skin - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common. | 112,816 |
What are the symptoms of Schindler disease type 1 ? | What are the signs and symptoms of Schindler disease type 1? The Human Phenotype Ontology provides the following list of signs and symptoms for Schindler disease type 1. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Abnormal pyramidal signs 90% Autism 90% Cataract 90% Cognitive impairment 90% Developmental regression 90% Hearing impairment 90% Hypertonia 90% Muscle weakness 90% Seizures 90% Strabismus 90% Visual impairment 90% Hemiplegia/hemiparesis 50% Hepatomegaly 50% Hyperkeratosis 50% Hypertrophic cardiomyopathy 50% Involuntary movements 50% Muscular hypotonia 50% Nystagmus 50% Optic atrophy 50% Telangiectasia of the skin 50% Vertigo 50% Aplasia/Hypoplasia of the cerebellum 7.5% Lymphedema 7.5% Paresthesia 7.5% Autosomal recessive inheritance - Cortical visual impairment - Generalized amyotrophy - Hyperreflexia - Increased urinary O-linked sialopeptides - Infantile onset - Intellectual disability, severe - Myoclonus - Osteopenia - Spasticity - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common. | 111,854 |
When did a protest in Delhi occur to protest against Chinese repression in Tibet? | April 16 | 8,415 |
What are the symptoms of Maturity-onset diabetes of the young, type 6 ? | What are the signs and symptoms of Maturity-onset diabetes of the young, type 6? The Human Phenotype Ontology provides the following list of signs and symptoms for Maturity-onset diabetes of the young, type 6. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Autosomal dominant inheritance - Maturity-onset diabetes of the young - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common. | 100,497 |
What is the British equivalent of a "buck"? | quid | 27,712 |
Time is one of how many fundamental physical quantities? | seven | 61,813 |
Which national event caused Beyonce to produce "Demand a Plan?" | Sandy Hook Elementary School shooting | 1,015 |
What was Albert Pike actually more of an expert in? | late 19th century Southern Freemasonry of the USA | 37,892 |
What are the genetic changes related to vitelliform macular dystrophy ? | Mutations in the BEST1 and PRPH2 genes cause vitelliform macular dystrophy. BEST1 mutations are responsible for Best disease and for some cases of the adult-onset form of vitelliform macular dystrophy. Changes in the PRPH2 gene can also cause the adult-onset form of vitelliform macular dystrophy; however, less than a quarter of all people with this form of the condition have mutations in the BEST1 or PRPH2 gene. In most cases, the cause of the adult-onset form is unknown. The BEST1 gene provides instructions for making a protein called bestrophin. This protein acts as a channel that controls the movement of charged chlorine atoms (chloride ions) into or out of cells in the retina. Mutations in the BEST1 gene probably lead to the production of an abnormally shaped channel that cannot properly regulate the flow of chloride. Researchers have not determined how these malfunctioning channels are related to the buildup of lipofuscin in the macula and progressive vision loss. The PRPH2 gene provides instructions for making a protein called peripherin 2. This protein is essential for the normal function of light-sensing (photoreceptor) cells in the retina. Mutations in the PRPH2 gene cause vision loss by disrupting structures in these cells that contain light-sensing pigments. It is unclear why PRPH2 mutations affect only central vision in people with adult-onset vitelliform macular dystrophy. | 95,084 |
How many people from the pre-election meeting in Lviv were detained? | nearly 300 | 56,570 |
In computer terms, what does CPU stand for? | central processing unit | 23,793 |
What portion of the Swedish population engages in a cappella singing? | 5% | 58,141 |
What were Luther's followers advised to use when governing worldly affairs? | reason | 84,791 |
When did THe Contemporary Art museum of the Louis Vuitton Foundation open? | October 2014 | 65,545 |
Two of the national parks in Hyderabad are Mrugavani National Park, Mahavir Harina Vanasthali National Park, what is the third? | Kasu Brahmananda Reddy National Park | 75,672 |
When did the financial relationship Switzerland had with Nazi Germany begin to raise controversy? | end of the 20th century | 50,990 |
How many Russians were in defense? | Russian army of 43,000 | 70,340 |
With what organization are many Gothic cathedral listed with as World Heritage Sites? | UNESCO | 49,407 |
Subsets and Splits