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{
"caption": "CT Abdomen showing venous thrombus and ischaemic bowels.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9272985-2-cureus-0014-00000025704-i01.jpg"
} | 009400 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Intraoperative image showing infarcted small bowel.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9272985-3-cureus-0014-00000025704-i02.jpg"
} | 009401 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "CT axial cross-section showing dilated small bowel loop.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9272985-4-cureus-0014-00000025704-i05.jpg"
} | 009402 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Showing two feet of the infarcted small bowel.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9272985-5-cureus-0014-00000025704-i04.jpg"
} | 009403 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "CT abdomen showing recanalisation of the portal vein.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9272985-6-cureus-0014-00000025704-i03.jpg"
} | 009404 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "NanoSIMS secondary ion signal intensity distribution maps and confocal microscopy images of an adherent SW480 cell after 24 h exposure to 25 μM cisplatin, revealing cisplatin colocalisation with acidic organelles in the cell. The screened region is marked with a frame in the differential interference contrast image of the cell (A). The confocal microscopy image of the (fluorine-containing) LysoTracker Red (D) demonstrates a correlation with the signal intensity patterns of both 19F− originating from LysoTracker Red (B) and 194Pt− originating from cisplatin (C) detected by NanoSIMS in the same cell. The arrows indicate a few regions of platinum accumulation without fluorescence and 19F− signal intensity enhancement (2 out of 20 labeled areas). Secondary ion signal intensities are displayed on a rainbow false-color scale ranging from dark blue to red for low to high intensities, respectively. The small misalignment between the fluorescence image and the secondary ion maps may originate from lens aberrations and/or cell shrinkage due to sample preparation. Scale bars = 5 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273000-1-c3sc53426j-f4.jpg"
} | 009405 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "NanoSIMS 194Pt− signal intensity distribution images obtained from semi-thin resin sections of SW480 cells treated with CDDP with various concentrations for 24 h. Signal intensities are displayed on a rainbow false-color scale, ranging from 0 counts per pixel (black) to max. 4 and 10 counts per pixel (red) for images from cells exposed to 0 to 10 μM and 25 to 150 μM CDDP, respectively. The primary ion beam was rastered over areas between 32 × 32 to 40 × 40 μm2 at a resolution of 512 × 512 pixels for a total dwell time of 200 to 300 ms per pixel. Scale bars = 5 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273000-3-c3sc53426j-f2.jpg"
} | 009406 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Exemplary 12C14N−, 34S−, 31P− and 194Pt− secondary ion signal intensity distribution maps acquired from semi-thin sections of SW480 cells treated with 25 μM of cisplatin. Regions of interest (ROIs) were manually defined within: (1) the cytoplasm; (2) the nucleus; (3) the nucleolus; and (4) the chromatin. According to the 194Pt− and 34S− signals, the drug is accumulated in small cytoplasmic, sulfur-rich aggregates (encircled in red), as well as in the nucleoli. Intensities are displayed on a rainbow false-color scale, ranging from dark blue to red for low to high intensities, respectively. The scale bars are 5 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273000-5-c3sc53426j-f1.jpg"
} | 009407 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Anti-Hwp1 immunolabeling of C. dubliniensis cells. Strain CD36 was grown for 2 h in 10% FBS diluted with MilliQ water, then immunolabeled with anti-Hwp1 MAb 2-E8 and a FITC-conjugated anti-mouse secondary antibody. Signal was observed toward the tip of some germ tubes. The scale bar in each image denotes 10 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273023-2-fcimb-12-907453-g005.jpg"
} | 009408 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "A C. albicans HWP1/HWP1 germ tube labeled with anti-Hwp1 MAb 2-E8 and a secondary anti-mouse, gold-conjugated antibody. Gold particles, marking the location of Hwp1, appeared in the micrograph as small, electron-dense dots distributed over the outermost surface of the germ tube. A portion of the image was enlarged (inset) to better visualize the gold particles. One gold particle was marked with an asterisk and over a dozen others were visible in the enlarged image.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273023-3-fcimb-12-907453-g002.jpg"
} | 009409 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Immunolabeling of C. albicans germ tubes with MAbs specific for Hwp1, Als1, and Als3. C. albicans strain CAI12 was pre-grown as yeast cells in YPD medium, then washed and transferred to RPMI medium for 70 min to form germ tubes. Germ tubes were labeled with anti-Hwp1 2-E8 followed by a secondary FITC antibody (depicted as a green color). Germ tubes were also directly labeled with Alexa Fluor 594-conjugated anti-Als3 (red color) and Alexa Fluor 633-conjugated anti-Als1 (false-colored blue). Pairs of signals were overlaid in other frames and marked accordingly. The yellow color in the “Hwp1, Als3” panel was the combination of individual signals from each protein, indicating shared localization. In contrast, overlaying either Hwp1 or Als3 with Als1 maintained the original colors for each protein, suggesting less overlap between Als1 with either Hwp1 or Als3. The scale bar in each image denotes 10 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273023-5-fcimb-12-907453-g006.jpg"
} | 009410 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Immunolabeling of C. albicans cells 10 min after placing them into RPMI 1640 medium to induce germ tube formation. C. albicans CAI12 was grown in YPD to saturation, then washed and placed into RPMI medium at 37°C and 200 rpm shaking. Cells were collected by filtration at various time points with a 10-min time point pictured. Immunolabeling with either anti-Hwp1 (left), anti-Als1 (center), or anti-Als3 (right) was used to follow the time course of protein detection on the surface of yeast cells at the earliest stages of germ-tube formation. At the 10-min time point, Hwp1 and Als1 were visible by immunolabeling while Als3 required additional incubation to produce a detectable signal.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273023-7-fcimb-12-907453-g007.jpg"
} | 009411 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Drawings and scans showing the septum perforation in the nasal cavity used in this study. The septal perforation is hatched on the drawings. Drawings adapted from the Servier Medical Art.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273033-8-fmedt-04-924501-g0003.jpg"
} | 009412 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "SARS-CoV-2 MA10 infection induces profibrotic gene expression at late time points. (A and B) Volcano plots of DSP DEGs are shown for diseased alveolar ROIs at (A) 15 and (B) 30 dpi versus mock 1-year-old female BALB/c mice. (C) DSP Q3 normalized counts of Spp1, Sparc, and Csf1r expression associated with profibrotic macrophage archetype are shown for mock, infected diseased (Dis), or intact (Int) ROIs at indicated time points in 1-year-old female BALB/c mice. (D and E)\nSpp1 expression was measured by RNA-ISH (D) and quantified and normalized to whole lung area (E). Scale bars indicate 1 mm. (F) DSP heatmap of selected profibrotic and fibrosis related genes in alveolar ROIs are shown for mock, 2, 15, and 30 dpi 1-year-old female BALB/c mice. DSP Q3 normalized counts of SARS-CoV-2 MA10 Spike (S) of ROIs are represented by gray color intensity. (G and H)\nFn1 expression (red) by RNA-ISH (G) with quantification (H) is shown. Scale bars indicate 1 mm. (I) DSP Q3 normalized counts of Tgfb1 (red) expression in alveolar ROIs was quantified at indicated time points in mock or SARS-CoV-2 MA10-infected 1-year-old female BALB/c mice. (J)\nTgfb1 expression was measured by RNA-ISH in subpleural diseased regions in a SARS-CoV-2 MA10 infected mouse at 30 dpi compared to mock. Scale bars = 1 mm (low power) and 100 μm (high power). DSP Q3 normalized count graphs in (C and I) represent all ROIs selected with each unique color representing one animal, bars represent average value of each group with error bars representing standard error of the mean . RNA-ISH quantification graphs (E and H) represent average value of each group with error bars representing standard error of the mean.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273046-0-scitranslmedpabo5070-f6.jpg"
} | 009413 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "SARS-CoV-2 MA10 infection causes lung damage in aged surviving mice.1-year-old female BALB/c mice were infected with 103 PFU SARS-CoV-2 MA10 (n=74) or PBS (n=24) and monitored for (A) percent starting weight and (B) survival. (C) Log transformed infectious virus lung titers were assayed at indicated time points. Dotted line represents LOD. Undetected samples are plotted at half the LOD. (D to F) Lung function was assessed by whole body plethysmography for (D) PenH, (E) Rpef, and (F) EF50. (G) Histopathological analysis of lungs at indicated time points are shown. H&E indicates hematoxylin and eosin staining. SMA indicates DAB-labeling (brown) immunohistochemistry for α-smooth muscle actin. Picrosirius Red staining (bright pink-red) highlights collagen fibers. Image scale bars represents 1000 μm for low magnification and 100 μm for 400X images. (H) Disease incidence scoring is shown for indicated time points: 0 = 0% of total area of examined section, 1 = less than 5%; 2 = 6 to 10%; 3 = 11 to 50%; 4 = 51 to 95%; 5 = greater than 95%. Graphs represent individuals necropsied at each time point (C and H), with the average value for each treatment and error bars representing standard error of the mean. Mock infected animals represented by open black circles and SARS-CoV-2 MA10 infected animals are represented by closed red circles.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273046-1-scitranslmedpabo5070-f1.jpg"
} | 009414 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Direct acting antiviral EIDD-2801 prevents lung damage and anti-fibrotic Nintedanib reduces peak disease in SARS-CoV-2 infected aged mice.1-year-old female BALB/c mice were infected with 103 PFU of SARS-CoV-2 MA10 (n=50) or PBS (n=5) then treated with EIDD-2801 (n=10) (500 mg/kg BID) or vehicle (n=45) starting at 12 hours post infection until 5 days post infection (blue shaded region). Animals were monitored for (A) weight loss and (B) survival. (C) Log transformed infectious virus lung titers were assayed at selected time points. Dotted line indicates LOD and undetected samples are plotted at half the LOD. (D) Pathology scores of mice as measured by lung congestion at time of harvest. (E) lung damage measured by evaluation of H&E staining for diffuse alveolar damage, (F) and acute lung injury. ND, not determined. (G) Histopathological analysis of lungs at indicated time points is shown. H&E indicates hematoxylin and eosin. SMA indicates DAB-labeling (brown) immunohistochemistry for α-smooth muscle actin. Picrosirius Red staining (bright pink-red) highlights collagen fibers. Scale bars represents 100 μm for 200X images. (H) Disease incidence scoring at indicated time points: 0 = 0% of total area of examined section, 1 = less than 5%; 2 = 6 to 10%; 3 = 11 to 50%; 4 = 51 to 95%; 5 = greater than 95%. 1-year-old female BALB/c mice were infected with 103 PFU of SARS-CoV-2 MA10 (n=90) or PBS (n=5) then treated with Nintedanib (n=45) or vehicle (n=50) starting at 7 days post infection until designated harvest date (shaded purple region). Animals were monitored for (I) weight loss and (J) survival. (K) Gross pathology scores of mice were measured by lung congestion at time of harvest. (L) Histopathological analysis of lungs at indicated time points were stained as in (G). Image scale bars represents 100 μm for 200X images. (M) Disease incidence scoring at indicated time points was recorded as in (H). (N) Serum nintedanib concentrations were measured. Graphs represent individuals collected at each time point in (B to F, H, J to L, and N), with the average value for each treatment and error bars representing standard error of the mean shown. Kruskal-Wallis (D, H) and two-way ANOVA (K, L) were performed and p-values are given with comparisons on each graph. Mock infected animals represented by open gray circles, vehicle treated SARS-CoV-2 MA10 infected animals are represented by closed red circles, EIDD-2801-treated SARS-CoV-2 infected animals are represented by closed blue circles, and nintedanib-treated SARS-CoV-2 infected animals are represented by closed purple circles.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273046-2-scitranslmedpabo5070-f7.jpg"
} | 009415 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Transitional alveolar epithelial cell genes are up-regulated following SARS-CoV-2 MA10 infection. (A) Normalized enrichment scores (ES) and adjusted p-values are shown for a customized ADI/DATP/PATS signature in diseased alveolar ROIs at 2, 15, or 30 dpi versus mock 1-year-old female BALB/c mice. The customized ADI/DATP/PATS signature was obtained from a reported data set (\n44\n–\n46\n). (B) A DSP heatmap of reported ADI/DATP/PATS marker genes in alveolar ROIs is shown for mock, 2, 15, and 30 dpi 1-year-old female BALB/c mice. DSP Q3 normalized counts of SARS-CoV-2 MA10 Spike (S) of ROIs are log10 transformed and represented by gray color intensity. (C) DSP Q3 normalized counts of Cdkn1a and Krt8 expression across alveolar ROIs in mock, infected diseased (Dis), or intact (Int) ROIs at indicated time points in 1-year-old female BALB/c mice. Graphs represent all ROIs selected with each unique color representing one animal, bars represent average value of each group with error bars representing standard error of the mean. The difference in DSP Q3 normalized counts for targeted genes in ROIs between each condition and time point was statistically tested using a linear mixed-effect model with condition and time point as fixed effects and replicate mice as random-effect factors. NS, not significant. (D) Histopathological analysis is shown for lungs isolated from mock or SARS-CoV-2 MA10-infected 1-year-old female BALB/c mice at indicated time points. Left: hematoxylin and eosin staining. Middle: DAB-labeling (brown) immunohistochemistry for Col1a1. Right: RNA-ISH for Sftpc, Krt8 and Cdkn1a. Scale Bars indicate 100 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273046-3-scitranslmedpabo5070-f4.jpg"
} | 009416 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Transcriptional digital spatial profiling reveals unique signatures in diseased tissue compartments. (A) Experimental setup for GeoMx digital spatial profiling (DSP). Regions of interest (ROIs) were selected from formalin-fixed paraffin embedded tissue sections from mock, 2, 15, and 30 dpi 1-year-old female BALB/c mice and analyzed by NanoString GeoMx Whole Transcriptome Atlas. (B) A table summarizing ROIs from each tissue compartment, disease state, and time point is shown. Each time point includes 3 independent mouse samples, with 3 to 4 ROIs per mouse. (C) Example of ROI selections from mock, 2 dpi, and 30 dpi post SARS-CoV-2 MA10 lungs are shown. Scale Bars = 5 mm for low magnification images and 500 μm for insets. Symbols define representative ROIs for each tissue compartment, disease state, and time point as indicated in the table in panel (B). Tissue sections were stained for nuclei (DAPI: blue), SARS-CoV-2 MA10 RNA (red), and CD45 (green). (D) DSP Q3 normalized counts of SARS-CoV-2 MA10 Spike (S) and ORF1ab expression are shown for mock, infected diseased (Dis), or intact (Int) ROIs. Graphs represent all ROIs selected with each unique color representing one animal, bars represent average value of each group with error bars representing standard error of the mean. (E and F) PCA plots of distal airway (E) and alveolar (F) ROIs are shown. Graphs represent all ROIs selected with each unique color and symbol representing disease state and time point, respectively. DSP Q3 normalized counts of SARS-CoV-2 MA10 Spike (S) of ROIs are represented by purple-blue fill color intensity.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273046-5-scitranslmedpabo5070-f2.jpg"
} | 009417 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Histological and transcriptional analyses reveal ADI/DATP/PATS cells are dynamically involved in alveolar regeneration following SARS-CoV-2 MA10 infection. (A) A DSP heatmap is shown for of ADI/DATP/PATS signature genes identified in COVID-19 autopsy lungs (\n47\n) in alveolar ROIs in mock, 2, 15, and 30 dpi 1-year-old female BALB/c mice. DSP Q3 normalized counts of SARS-CoV-2 MA10 Spike (S) of ROIs are represented by gray color intensity. (B) RNA-ISH of Sftpc and ADI/DATP/PATS cell markers Krt8 and Cdkn1a is shown over time course after SARS-CoV-2 MA10 infection, with selected areas of interest at indicated time points. Morphologically intact alveolar regions were selected at 15 and 30 dpi. Scale Bars = 25 μm. (C) Immunohistochemistry of Krt8 with AT1 (Ager) (i) and AT2 (Sftpc) (ii) cell markers is shown. Scale Bars = 20 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273046-6-scitranslmedpabo5070-f5.jpg"
} | 009418 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Example of waist detection (blue circle).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273061-11-ponep0267393pg005.jpg"
} | 009419 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "New manufacturing design to control the VCSEL eccentricity.a) top view CLP of the CLP, the arrow illustrates the meridian of the cross section depicted in b); b) cross-section showing the VCSE in its housing.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273061-3-ponep0267393pg011.jpg"
} | 009420 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Chromatin integrity, oxidative damage and protamine content.(A) Electron micrographs of condensed spermatids and mature sperm of Prm2+/Δc, Prm2-/Δc and WT. Scale bars = 1μm unless otherwise indicated. (B) Immunohistochemical fluorescent staining of 8-Oxo-2’-deoxyguanosine (8-OHdG) (green) in caput epididymis (upper row) and cauda epididymis (lower row) of Prm2+/Δc, Prm2-/Δc and WT. Counterstained with DAPI (pseudo-colored grey). Scale bar = 50μm. (C) Boxplot showing the percentage of PRM2 (including PRM2 precursors) of total protamine by band density analysis of Coomassie stained acid urea gel electrophoresis (AU-PAGE) (S8C Fig). Asterisk indicates significant difference. To the right: AU-PAGE of WT, Prm2+/Δc and Prm2-/Δc mature sperm basic nuclear protein extractions, equal amounts of pooled sample loaded per genotype. a = non-protamine basic proteins, b = PRM2 precursors, open arrowhead indicates mature PRM2 band, solid arrowhead indicates PRM1 band. Below: Immunoblot of PRM1, PRM2, cP2 (indicating the presence of PRM2 precursor) and ODF2.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273070-0-pgenp1010272pg004.jpg"
} | 009421 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Sperm and testis parameters and histology.(A) Bar plots showing data for relative testes mass, mature sperm count, percentage of viable mature sperm (eosin-nigrosin assay) and percentage of motile mature sperm in Prm2+/Δc and Prm2-/Δc mice compared to wildtype. (B) PAS staining of testis and epididymal sections of Prm2+/Δc, Prm2-/Δc and WT males. Scale bar = 50μm (200μm for left column).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273070-1-pgenp1010272pg003.jpg"
} | 009422 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Localization and translation timing of PRM1, PRM2, unprocessed PRM2 and DNA condensing ability of Prm2Δc.(A) Immunohistochemical fluorescent staining of PRM2 (WT, Prm2+/Δc) or mP2 (Prm2+/Δc, Prm2-/Δc) (green) and PRM1 (all genotypes) (green) in testis sections, counterstaining with DAPI (pseudo-colored grey). Scale bar = 50μm. (B) Immunohistochemical fluorescent staining of unprocessed PRM2 (red) using a cP2-specific antibody in testis sections, counterstained with DAPI (pseudo-colored grey). Scale bar = 50μm. C) Fluorescent images of human embryonic kidney 293 (HEK) cells 48 hours post-transfection with plasmids encoding eGFP tagged PRM2 (Prm2-eGFP) or Prm2Δc (Prm2Δc-eGFP) (green), counterstained with Hoechst (pseudo-colored grey). Scale bar = 50μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273070-2-pgenp1010272pg002.jpg"
} | 009423 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Histone H3, histone H4 and transition protein 1 IHC staining and western blot detection.(A) Two left columns: Immunohistochemical fluorescent staining of TNP1 (red) in WT, Prm2+/Δc and Prm2-/Δc step 15–16 spermatids and caput epididymis sections, counterstained with DAPI (pseudo-colored grey). Scale bar = 50μm. Two right columns: Immunohistochemical fluorescent staining of Histone H3 (H3) or Histone H4 (H4) (red) in WT, Prm2+/Δc and Prm2-/Δc caput epididymis sections counterstained with DAPI (pseudo-colored grey). Scale bar = 50μm. (B) Immunoblots against TNP1 and H3 and H4 and ODF2 as a control in testis (WT), caput epididymis (caput) and mature sperm (sperm) basic nuclear protein extractions (WT, Prm2+/Δc and Prm2-/Δc).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273070-3-pgenp1010272pg005.jpg"
} | 009424 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Representative images of ground truth and eight-class segmentation using U-Net.(A) Whole-slide image of segmentation using U-Net in a specimen with tubulointerstitial nephritis. (B) PAS-stained slide, ground truth, and segmentation using U-Net. The top row represents a normal specimen; the middle and bottom rows represent specimens with tubulointerstitial nephritis.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273082-2-ponep0271161pg001.jpg"
} | 009425 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Representative images of ground truth and eight-class segmentation using U-Net.(A) Whole-slide image of segmentation using U-Net in a specimen with tubulointerstitial nephritis. (B) PAS-stained slide, ground truth, and segmentation using U-Net. The top row represents a normal specimen, and the second through fourth rows represent specimens with tubulointerstitial nephritis.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273082-5-ponep0271161pg002.jpg"
} | 009426 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Bronchoscopic characteristic of psittacosis pneumonias.Mild hyperemia and swelling of bronchial mucosa, a little of white secretions, and patency of grade 1–4 bronchi in bilateral lungs were displayed in a patient (A, B, C, D) with psittacosis pneumonias in the right upper lobe and another patient (E, F, G, H) with the left upper lobe lesions by bronchoscopy, respectively. RUL, right upper lobe; LUL, left upper lobe; LLL, left lower lobe; RLL, right lower lobe.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273088-3-ponep0270896pg002.jpg"
} | 009427 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Radiologic characteristic of psittacosis pneumonia.Large consolidation or ground-glass opacities with air bronchial shadow were mostly identified in the right upper lobe (A, B), the right middle lobe (C), the right lower lobe (D), the left upper lobe (E, F), the left lower lobe (G), and the lower lobes of both lungs (H). The arrows in (I), indicated right pleural effusion and mild pericardial effusion.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273088-4-ponep0270896pg001.jpg"
} | 009428 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Inhibition of ER stress by 4-PBA reduces diaphragm atrophy during MV. (A) Representative immunofluorescence staining images of diaphragm myofibers. (B–D) The administration of 4-PBA (ER stress inhibitor) reduced the CSAs of diaphragm myofibers in rats subjected to SB. In contrast, the cross-sectional areas (CSAs) of myofibers in the MV + 4-PBA group were significantly higher than those in the MV group. *p < 0.001 (ANOVA followed by the Tukey HSD test, n = 6 per group). MV = mechanical ventilation; SB = spontaneous breathing; 4-PBA = 4-phenylbutyrate.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273093-3-fphys-13-897559-g003.jpg"
} | 009429 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Snapshots of the MIGS procedure.(1) Making a small hole in the cornea by incising it. (2)(3) Cleaving the TM membrane in the eye module.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273099-9-ponep0271171pg007.jpg"
} | 009430 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Biological evaluation of CHPC with different hydrogel concentrations. (A) Preparation of CHPC. The HPC hydrogels mixed with chondrocytes were placed into a syringe, crosslinked by light irradiation and cut into 2 mm cylinders, and cultured in the culture medium. (B) Schematic of the HP bioreactor, and images of the culture tank and HP machine. (C) Live and dead cell staining of CHPC after culturing for 0 days, 1 week, and 2 weeks (D) CCK-8 results of chondrocytes cultured in culture medium mixed with five‰ HPC hydrogels. HPC hydrogels of different concentrations in culture medium did not affect cell proliferation. (E–F) The relative area of live cells (E) and the average fluorescence intensity (F) (p < 0.001), the semi-quantitation results of Figure 2B.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273133-4-fbioe-10-916146-g002.jpg"
} | 009431 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Biological behavior evaluation of chondrocytes mediated by HP. (A) Front and longitudinal section view of CHPC cultured in vitro. (B–C) The wet weight (B) and volume (C) (p < 0.05) of CHPC cultured in vitro. (D) Live and dead cell staining of CHPC cultured in vitro. (E) DNA quantification (p < 0.001) of CHPC cultured in vitro. (F–G) The relative area of live cells (F) and the average fluorescence intensity (G) (p < 0.001), the semi-quantitation results of Figure 3D.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273133-7-fbioe-10-916146-g003.jpg"
} | 009432 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Mid-esophageal view of Transesophageal echocardiogram showing flail P2 portion of the mitral valve.LA: Left atrium, LV: Left ventricle",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273166-0-cureus-0014-00000025854-i01.jpg"
} | 009433 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "M-mode, mid-esophageal view of transesophageal echocardiogram showing flail mitral leaflet (white arrow) resulting in eccentric regurgitant flow (green arrow) from LV to LA.LA: Left atrium, LV: Left ventricle",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273166-1-cureus-0014-00000025854-i02.jpg"
} | 009434 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "(A) Post-contrast MRI of the left foot showing focal area of hypoenhancement surrounded by hyperenhancement at the web space between the third and fourth toe; (B) Histopathologic examination of the left foot tissue with PAS stain showing angio-invasive septated hyphae (black arrows); (C) Fusarium solani isolated from Sabouraud dextrose agar at 30°C; (D) Microscopy examination of the fungal culture using lactophenol cotton blue stain showing canoe-shaped micro- and macroconidia, characteristic of Fusarium.PAS: Periodic Acid-Schiff",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273167-0-cureus-0014-00000025847-i01.jpg"
} | 009435 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Hypopigmentation rash in a \"salt and pepper\" appearance on patient's back",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273168-0-cureus-0014-00000025856-i03.jpg"
} | 009436 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Chest X-ray showing pulmonary infiltrates on the leftThe blue arrow indicates an area of ill-defined infiltrates in the lower lobe of the left lung.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273171-0-cureus-0014-00000025846-i02.jpg"
} | 009437 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "CT angiogram of the chestThe red arrow indicates an area of airspace consolidation on the lower lobe of the left lung",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273171-1-cureus-0014-00000025846-i03.jpg"
} | 009438 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Transthoracic echocardiogram showing elevated systolic left ventricle internal dimension with left ventricular dilation",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273172-0-cureus-0014-00000025975-i03.jpg"
} | 009439 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Computed tomography with angiography of the chest showing diffuse multifocal opacities",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273172-1-cureus-0014-00000025975-i02.jpg"
} | 009440 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Chest radiography showing diffuse multifocal nodular opacities",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273172-2-cureus-0014-00000025975-i01.jpg"
} | 009441 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "CTA of the next showing no large vessel (intracranial or extracranial) occlusion. No hemodynamically significant arterial stenosisCTA: computed tomography angiography",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273173-1-cureus-0014-00000025860-i04.jpg"
} | 009442 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Repeated brain CT scan (sagittal view) showing no sign of bleeding or obvious infarction. Hyperdensity (arrow) due to thrombosed vain at the cortical convexity.CT: computed tomography.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273173-2-cureus-0014-00000025860-i05.jpg"
} | 009443 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "MRI-FLAIR with hyperintensity signal due to cerebral vein thrombosis (arrow)MRI: magnetic resonance imaging; FLAIR: fluid-attenuated inversion recovery",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273173-4-cureus-0014-00000025860-i01.jpg"
} | 009444 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Chest x-ray showing no lymphadenopathy or obvious cardiopulmonary pathology",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273173-6-cureus-0014-00000025860-i07.jpg"
} | 009445 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "CT of the head without contrast identified open-lip schizencephaly on the right (red arrow) with possible superimposed periventricular leukomalacia adjacent to the right atria.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273174-0-cureus-0014-00000025848-i01.jpg"
} | 009446 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Color Doppler ultrasound of the right vertebral arteryColor Doppler ultrasound showed an intraluminal thrombus (blue arrow) in the right vertebral artery, likely related to an underlying dissection.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273176-0-cureus-0014-00000025850-i03.jpg"
} | 009447 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Cerebral angiogram pre-thrombectomy, post-thrombolysis in cerebral infarction (TICI) grade 3 recanalization, and at six-week follow-upThe patient underwent successful emergent mechanical thrombectomy in the right middle cerebral artery with extended thrombolysis in cerebral infarction (eTICI) grade 3 recanalization. She was subsequently placed on systemic anticoagulation and a follow-up catheter angiogram done six weeks later showed spontaneous resolution of thrombus in the right vertebral artery with moderate residual stenosis (blue arrow).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273176-1-cureus-0014-00000025850-i04.jpg"
} | 009448 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Follow-up CT angiogram of the head and neck showing restored patency of the right vertebral arteryA follow-up CT angiogram of the head and neck performed after four months showed resolution of the dissection and restored patency of the right vertebral artery (left arrow). The right vertebral artery can be seen traversing through the transverse foramina of the cervical spine (right arrow).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273176-2-cureus-0014-00000025850-i05.jpg"
} | 009449 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "CT angiogram of the head and neck showing aberrant right subclavian arteryCT angiogram of the head and neck showed an aberrant right subclavian artery (blue arrow) arising directly from the aortic arch distal to the left subclavian artery and traversing posterior to the trachea and esophagus.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273176-3-cureus-0014-00000025850-i02.jpg"
} | 009450 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "CT angiogram of the head and neck showing aberrant right vertebral arteryCT angiogram of the head and neck showed an occlusion of the corresponding M2 branch and an incidental finding of an aberrant right vertebral artery arising from the right proximal common carotid artery, which appeared to be severely stenosed in its proximal cervical segment (blue arrow).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273176-4-cureus-0014-00000025850-i01.jpg"
} | 009451 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Extensive choledocholithiasis",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273191-0-cureus-0014-00000025795-i02.jpg"
} | 009452 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Red arrows in images A and B showing a 10 Fr x 7 cm double pigtail stent placed into the bile duct",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273191-1-cureus-0014-00000025795-i03.jpg"
} | 009453 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Green arrow in image A showing a 3 mm sessile polyp and blue arrows in image B showing small and large diverticulosis",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273191-2-cureus-0014-00000025795-i04.jpg"
} | 009454 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Cholelithiasis",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273191-3-cureus-0014-00000025795-i01.jpg"
} | 009455 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Intraoperative image demonstrating mucinous deposit in the peritoneal cavity.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273193-0-cureus-0014-00000025832-i02.jpg"
} | 009456 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "CT demonstrating 5.6 x 4.9 centimeter mass at the tip of the appendix.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273193-1-cureus-0014-00000025832-i01.jpg"
} | 009457 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Gastric adenocarcinoma immunohistochemistry shows high microsatellite instability with loss of both MLH-1 and PMS-2 (MSI-High) (A and C) and increased enhancement in MLH-2 and MSH-6 (B and D).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273196-0-cureus-0014-00000025820-i01.jpg"
} | 009458 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Gastric adenocarcinoma microscopic sections show areas of moderately differentiated gastric adenocarcinoma (arrow) (A) with adjacent benign gastric epithelium (B).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273196-3-cureus-0014-00000025820-i03.jpg"
} | 009459 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "CT angiogram of the thorax illustrating the irregular appearance of the liver dome that was inseparable from the right lower lobe of the lungs (arrow).CT: computerized tomography",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273197-0-cureus-0014-00000025836-i01.jpg"
} | 009460 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "A panel of CT images demonstrates hyper-attenuating structures within the right lower lobe cavity, suggestive of gallstones.CT: computerized tomography",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273197-1-cureus-0014-00000025836-i02.jpg"
} | 009461 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Photo demonstrating the patient’s cellulitis of her RLE during her first hospital stay.RLE: Right-lower extremity",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273199-2-cureus-0014-00000025816-i01.jpg"
} | 009462 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Photo demonstrating the patient’s cellulitis of her RLE during her first hospital stay.RLE: Right-lower extremity",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273199-3-cureus-0014-00000025816-i02.jpg"
} | 009463 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Post-surgical RLE photo demonstrating mild improvement of the cellulitis compared to admission. The decision was made to return home in the following days.RLE: Right-lower extremity",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273199-6-cureus-0014-00000025816-i03.jpg"
} | 009464 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "MRI brain and X-ray of the skeletal system of SIODAxial T2 (a) and FLAIR (b) MRI images showed a hyperintense lesion in the left temporo-parieto-occipital lobe with gyriform T1 hyperintensity on T1 images (c). No restricted diffusion was diffusion seen on DWI images(d) and without blooming on SWI images(e). T2 hyperintense lesions with FLAIR suppression (b) were also seen in the right corpus striatum and posterior part of the right putamen s/o chronic infarcts. On TOF COW (f) and Magnetic resonance angiography (g), non-visualization of both supraclinoid internal carotid arteries (left>right) with mild proximal narrowing of the left internal carotid artery and prominent basal and pial collaterals. On post-contrast axial (h), enhancement of the infarct was seen. On vessel wall imaging pre (i) and post (j), narrowing with negative remodeling was seen in both supraclinoid ICA with a minimal enhancement of vessel wall imaging. Lateral view of lumbar spine X-ray (k) showed decreased posterior vertebral body height in lumbar and visualized thoracic vertebral bodies with thin ribs. AP view of pelvis X-ray (l) showed flattening of both femoral epiphyses with broadened iliac crest and pubic diastasis. AP view of both knee X-rays (m) showed flattening of both tibial epiphyses. X-ray of both hands (n) showed epiphyseal beaking in both metacarpals. X-ray chest PA view (o) showed thin ribs with a broad chest.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273200-0-cureus-0014-00000025838-i01.jpg"
} | 009465 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "High-resolution computed tomography after 24 hours in the internal medicine ward",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273201-0-cureus-0014-00000025833-i03.jpg"
} | 009466 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Thyroid ultrasonography with doppler",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273201-1-cureus-0014-00000025833-i04.jpg"
} | 009467 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Contrasted pulmonary computer tomographic scan taken in the emergency room",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273201-2-cureus-0014-00000025833-i02.jpg"
} | 009468 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "CT imaging of the lungs showing mild ground glass opacities in the right lung.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273202-0-cureus-0014-00000025824-i01.jpg"
} | 009469 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "MRI of the cervical spine with (A) fat saturated T2 imaging, (B) T1 imaging, and (C) T1 imaging with gadolinium-based contrast showing evidence of discitis/osteomyelitis centered at C3-4 with adjacent paravertebral abscesses, and suggestion of epidural phlegmon in the anterior epidural soft tissues of C2 and C3.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273202-1-cureus-0014-00000025824-i02.jpg"
} | 009470 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Clinical manifestations after surgeryA) The contour of the digits is significantly improved. The scar is imperceptible on the dorsal and ventral surfaces of the hand.B) The patient has no movement limitations.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273203-0-cureus-0014-00000025802-i06.jpg"
} | 009471 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Clinical findingsSoft tissue was swelling around the proximal interphalangeal (PIP) joints of the third finger on both hands.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273203-1-cureus-0014-00000025802-i01.jpg"
} | 009472 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "OperationA) The design of midaxial incision with a Z-plasty.B) The lesion was located outside of the radial and ulnar collateral ligament of the proximal interphalangeal (PIP) joint of the third finger. The neurovascular bundles were located at the palmar and inner sides of the lesion. C) The surgical site was closed with 5-0 nylon.D) Gross examination showed that the lesion was composed of soft tissue thickening.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273203-3-cureus-0014-00000025802-i04.jpg"
} | 009473 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Magnetic resonance imagingMagnetic resonance imaging revealed soft tissue thickening outside of the radial and ulnar collateral ligament of the bilateral third proximal interphalangeal (PIP) joint. The bone cortex, ligaments, and joint space are intact.A) On a T1-weighted image, the lesions were hypointense.B) On a STIR T2-weighted image, the lesions were not as hyperintense.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273203-4-cureus-0014-00000025802-i03.jpg"
} | 009474 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Plain radiographPlain radiographs of the hands showing no bone destruction or joint space narrowing.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273203-5-cureus-0014-00000025802-i02.jpg"
} | 009475 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "CT scan of the chest: Massive bulla within the left lung completely replacing the left upper lobe. Multiple additional large bullae (arrows) are present within the left lower lobe. Moderately severe diffuse air trapping within the right lung consistent with emphysema with fibrotic changes.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273205-0-cureus-0014-00000025837-i02.jpg"
} | 009476 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Chest x-ray: Multiple massive bullae formation (arrows) within the left lung. Moderate reticular interstitial opacities of the right lower lobe consistent with pulmonary fibrosis versus infiltrates.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273205-1-cureus-0014-00000025837-i01.jpg"
} | 009477 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Forearm fasciitis with the destruction of the skin, underlying fascia, and multiple soft tissue defects with necrotic purulent discharge.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273206-0-cureus-0014-00000025829-i01.jpg"
} | 009478 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Three weeks post-split-thickness skin graft application showing healing with surrounding granulation tissue visualized.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273206-1-cureus-0014-00000025829-i02.jpg"
} | 009479 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "ATAD1Δα11 expression level impacts substrate mislocalization in wild-type (WT) HeLa cells.(A) Representative average intensity projection images of live WT HeLa cells stably expressing EGFP-Gos28 and transiently expressing ATAD1Δα11-HaloTag. EGFP-Gos28 was only seen on the Golgi apparatus (bottom row). However, a small population of cells (top row) showed mislocalization of EGFP-Gos28 to the mitochondria. These cells also had a higher level of ATAD1Δα11-HaloTag expression (the Pearson correlation coefficient [PCC] of cells shown in the images are indicated in panel B by arrows of matching colors). (B) The expression level of ATAD1Δα11 was plotted against the PCC for each cell. Linear regression analysis was preformed and there was a significant positive correlation between the two variables (p<0.0001).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273213-16-elife-73941-fig4-figsupp2.jpg"
} | 009480 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Live-cell imaging showing the ATAD1-dependent localization of EGFP-Pex26.Representative average intensity projection images of live HeLa ATAD1-/- cells stably expressing EGFP-Pex26 (top row) and transiently expressing ATAD1-HaloTag (bottom row). Mitochondria are stained with MitoTracker red. The individual channels are shown in black and white, and overlay of the EGFP and the MitoTracker red channels are shown in the right-most column with Hoechst-stained nuclei in blue.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273213-23-elife-73941-fig3-figsupp2.jpg"
} | 009481 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Live-cell imaging showing the pore-loop dependent localization of EGFP-Gos28 in ATAD1-/- HeLa cells.Representative average intensity projection images of live HeLa ATAD1-/- cells stably expressing EGFP-Gos28 and transiently expressing ATAD1-HaloTag pore-loop mutants (as indicated on the far-left panel). The individual channels are shown in black and white, and overlay of the EGFP and the MitoTracker channels are shown in the right-most column with Hoechst-stained nuclei in blue.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273213-3-elife-73941-fig5-figsupp1.jpg"
} | 009482 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Testing the effect of the disease-relevant mutations of ATAD1.(A) Mean Pearson correlation coefficient (PCC) values and the SEM between EGFP-Gos28 and the mitochondria when expressing the ATAD1 bearing disease-relevant mutations. Individual cell PCC values are represented as a single dot. Significance values were calculated using the Mann-Whitney test. ****p<0.0001, *p<0.05. The raw image files used for this analysis are available on Dryad. (B) Mean PCC values derived from the localization pipeline from each biological replicate were plotted for each mutant in ATAD-/- HeLa cells. Each dot represents a biological replicate, with an average of 43 cells per replicate. (C) Representative average intensity projection images of live HeLa ATAD1-/- cells stably expressing EGFP-Gos28 and transiently expressing ATAD1 mutants (as indicated on the far-left panel). The individual channels are shown in black and white, and overlay of the EGFP and the MitoTracker channels are shown in the right-most column with Hoechst-stained nuclei in blue.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273213-8-elife-73941-fig4-figsupp4.jpg"
} | 009483 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Elp1 expression is retained in TrkB and TrkC neurons in Elp1 CKO.(A–R) Representative images of fluorescent immunohistochemistry on serial horizontal sections showing TrkA (A, D, C, and F, green), TrkB (G, J, I, and L, green), or TrkC (M, P, Q, and R, green), with Elp1 (B, C, E, F, H, I, K, L, N, O, Q, and R, purple) in the trigeminal ganglion of Control (A–C, G–I, and M–O, n=3) or Elp1 CKO (D–F, J–L, and P–R, n=3) littermates at embryonic day 12.5 (E12.5). Arrowheads point to Elp1-expressing cells in Elp1 CKO (E, F, K, L, Q, and R). Scale bar: 20 µm (A), applies to (B–R).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273214-0-elife-71455-fig5-figsupp2.jpg"
} | 009484 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Trigeminal nerve branches are less complex or absent in Elp1 CKO at embryonic day 12.5 (E12.5).(A) Schematic depicting relevant cranial anatomy in E12.5 mouse: CR: central root; CT: chorda tympani nerve; e: eye; Fr: frontal nerve; GG: geniculate ganglion; Io: infraorbital nerve; MnV: mandibular nerve; MxV: maxillary nerve; Na: nasal nerve; NT: neural tube; OpV: ophthalmic nerve; and TG: trigeminal ganglion. (B–G) Representative maximum intensity projections of confocal Z-stacks through Control (B–D) or Elp1 CKO (E–G) littermates, which were processed for whole-mount immunohistochemistry to detect Tubb3 (white), followed by tissue clearing. (C, D, F, and G) Higher magnification images of the frontal nerve (C and F) or the infraorbital nerve at the developing whisker pad (D and G). Arrows indicate small central root (E), disorganized axons (F), and the absence of the nasal nerve (G) in Elp1 CKO. (H) Quantification of the size of the TG in Control (blue, 1010 µm, n=3) and Elp1 CKO (orange, 978.1 µm, n=4, p=0.0828, unpaired t-test with Holm-Sidak adjustment for multiple comparisons). (I) Quantification of the central root diameter in Control (blue, 546.9 µm, n=3) and Elp1 CKO (orange, 396.8 µm, n=4, p=0.0828, unpaired t-test adjusted for multiple comparisons). (J) Diagram explaining modified Sholl analysis, with concentric circles of increasing radii overlayed on representative traces (green) of the frontal nerve in Control (left) or Elp1 CKO (right). (K) Graph of modified Sholl analysis to quantify complexity of frontal nerve. Individual distributions are plotted in light blue (Control, n=2) and light orange (Elp1 CKO, n=4), while group averages are plotted in dark blue (Control) and dark orange (Elp1 CKO). (L) Quantification of the infraorbital nerve extent in Control (blue, 9374 µm, n=3) and Elp1 CKO (orange, 7061 µm, n=4, p=0.0004, unpaired t-test adjusted for multiple comparisons). Values for histograms represent mean ± SEM. Scale bar: 200 µm (B), applies to E; 200 µm (C), applies to D, F, and G. Refer to Figure 4—source data 1 for quantitative summary data represented in graphs.\nFigure 4—source data 1.Trigeminal nerve branches are less complex or absent in Elp1 CKO at embryonic day 12.5 (E12.5).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273214-1-elife-71455-fig4.jpg"
} | 009485 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Elp1 protein is not enriched in Pax3-positive neural crest cells or glial progenitors in the developing trigeminal ganglion.(A–H) Fluorescent immunohistochemistry on representative horizontal sections from embryonic day 10.5 (E10.5) (A–D) and E11.5 (E–H) Control mouse embryos demonstrating expression of Elp1 (A–H, green), Isl1 (A–C, E, and G, purple), and Pax3 (B, D, F, and H, red). (C and D) Higher magnification of box in A and B. (G and H) Higher magnification of box in E and F. Carets point to Isl1-positive neuronal nuclei (C, D, G, and H). Arrowheads denote Pax3-positive neural crest cells (C and D) or glial progenitors (G and H), while arrows indicate axons (G and H). Scale bars: 50 µm (A), applies to B, E, and F; 20 µm (C), applies to D, G, and H.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273214-10-elife-71455-fig1-figsupp1.jpg"
} | 009486 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Six1 is first expressed by placodal neurons, followed by neural crest-derived neurons in the trigeminal ganglion.(A–C, E–G, and I–K) Representative images of fluorescent immunohistochemistry showing Sox10 (B and C, purple) or Six1 (F, G, J, and K, purple) with native green fluorescent protein (GFP) fluorescence in horizontal sections at embryonic day 10.5 (E10.5) (A–C and E–G, n=3) and E12.5 (I–K, n=3) in Wnt1-Cre; ROSAmT/mG reporter embryos. Arrowheads point to neurons that co-express Sox10 (A–C) or Six1 (E–G and I–K) with GFP. (D, H and L) Pie charts demonstrating the percent of Sox10-positive (D) or Six1-positive (H and L) cells that co-express GFP in Wnt1-Cre; ROSAmT/mG trigeminal ganglia at E10.5 (D and H) and E12.5 (L). Scale bars: 20 µm (A), applies to all images. Refer to Figure 7—source data 1 for quantitative summary data represented in graphs.\nFigure 7—source data 1.Six1 is first expressed by placodal neurons, followed by neural crest-derived neurons in the trigeminal ganglion.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273214-11-elife-71455-fig7.jpg"
} | 009487 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Aberrant apoptosis contributes to loss of neural crest-derived TrkA neurons in Elp1 CKO trigeminal ganglia.(A–H) Fluorescent immunohistochemistry on representative horizontal sections from embryonic day 12.5 (E12.5) Control (A–C) or Elp1 CKO (D–H) littermates revealing expression of TrkA (A, C, D, and F–H, purple) with TUNEL staining (B, C, E, F, and H, green). (G and H) Higher magnification of box in F. Arrowheads point to TrkA neurons that are TUNEL-positive (G and H). (I) Quantification of TUNEL fluorescence in Control (blue, 675 a.u., n=3) and Elp1 CKO (orange, 8248 a.u., n=3, p=0.0052, nested unpaired t-test) trigeminal ganglia at E12.5. Values are mean ± SEM. *p=0.0224, unpaired t-test. a.u.: arbitrary units. Scale bars: 50 µm (A), applies to (B–F); 10 µm (G), applies to (H). Refer to Figure 9—source data 1 for quantitative summary data represented in graphs.\nFigure 9—source data 1.Aberrant apoptosis contributes to loss of neural crest-derived TrkA neurons in Elp1 CKO trigeminal ganglia.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273214-12-elife-71455-fig9.jpg"
} | 009488 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Normal developmental Trk expression dynamics in the trigeminal ganglion and maxillary nerve.(A–C) Representative images of fluorescent immunohistochemistry on serial horizontal sections showing TrkA (A, green), TrkB (B, green), or TrkC (C, green) with Isl1 (A–C, purple) in Control embryos at embryonic day 11 (E11). Arrows point to the maxillary nerve (MxV). (D and E) Representative maximum intensity projections of confocal Z-stacks through the Control maxillary process at E11.5 after whole-mount immunohistochemistry to detect Tubb3 (D, white) and TrkA (E, white), followed by tissue clearing. (F–K) Representative images of fluorescent immunohistochemistry on serial horizontal sections showing TrkA (F and I, green), TrkB (G and J, green), or TrkC (H and K, green) in Control embryos at E11.5 (F–H) and E12.5 (I–K). Scale bars: 50 µm (A), applies to (B and C); 100 µm (D), applies to (E); 100 µm (F), applies to (G and K).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273214-13-elife-71455-fig6-figsupp1.jpg"
} | 009489 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Progressive trigeminal nerve abnormalities arise in Elp1 CKO starting at embryonic day 11.5 (E11.5).(A) Schematic depicting relevant cranial anatomy in E11.5 mouse: CR: central root; CT: chorda tympani nerve; e: eye; GG: geniculate ganglion; MnV: mandibular nerve; MxP: maxillary process; MxV: maxillary nerve; NT: neural tube; OpV: ophthalmic nerve; and TG: trigeminal ganglion. (B–G) Representative maximum intensity projections of confocal Z-stacks through Control (B–D) or Elp1 CKO (E–G) littermates, which were processed for whole-mount immunohistochemistry to detect Tubb3 (white), followed by tissue clearing. (C, D, F, and G) Higher magnification of boxes in B and E. Arrows indicate disorganized axons (F and G) in Elp1 CKO. (H) Quantification of the size of the TG in Control (blue, 835.5 µm, n=4) and Elp1 CKO (orange, 834.3 µm, n=3, p=0.9497, unpaired t-test with Holm-Sidak adjustment for multiple comparisons). (I) Quantification of the central root diameter in Control (blue, 405.9 µm, n=4) and Elp1 CKO (orange, 427.7 µm, n=3, p=0.9497, unpaired t-test adjusted for multiple comparisons). Values for histograms represent mean ± SEM. Scale bar: 200 µm (B), applies to E; also applies to C, D, F, and G as 50 µm. Refer to Figure 3—source data 1 for quantitative summary data represented in graphs.\nFigure 3—source data 1.Progressive trigeminal nerve abnormalities arise in Elp1 CKO starting at embryonic day 11.5 (E11.5).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273214-2-elife-71455-fig3.jpg"
} | 009490 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Apoptosis in Elp1 CKO is not a result of altered nerve growth factor (NGF) expression in target tissues.(A–L) Fluorescent immunohistochemistry on representative horizontal sections through the whisker pad (A–F) or upper lip (G–L) of embryonic day 12.5 (E12.5) Control (A–C and G–I, n=3) and Elp1 CKO (D–F and J–L, n=3) littermates, revealing expression of NGF (A, C, D, F, G, I, J, and L, purple) and Tubb3 (B, C, E, F, H, I, K, and L, green). Scale bars: 50 µm (A), applies to (B–L).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273214-3-elife-71455-fig9-figsupp2.jpg"
} | 009491 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Initial trigeminal ganglion formation appears normal in Elp1 CKO at embryonic day 10.5 (E10.5).(A) Schematic depicting relevant cranial anatomy in E10.5 mouse: CT: chorda tympani nerve; e: eye; GG: geniculate ganglion; MnV: mandibular nerve; MxP: maxillary process; MxV: maxillary nerve; NT: neural tube; OpV: ophthalmic nerve; PA: pharyngeal arch; and TG: trigeminal ganglion. (B and C) Lateral view of trigeminal and geniculate ganglia in Control and Elp1 CKO (Wnt1-Cre+;Elp1flox/flox) littermates after Tubb3 whole-mount immunohistochemistry (white) to label neurons. (D) Quantification of the size of the TG in Control (blue, 885.3 µm, n=3) and Elp1 CKO (orange, 892.7 µm, n=3, p=0.8247, unpaired t-test with Holm-Sidak correction for multiple comparisons). (E) Quantification showing the ratio of Sox10-positive cells to Six1-positive cells in Control (blue, 0.96, n=3) and Elp1 CKO (orange, 0.94, n=3, p=0.8232, nested unpaired t-test adjusted for multiple comparisons). (F) Quantification showing the ratio of Sox10-positive cells to Isl1-positive cells in Control (blue, 1.04, n=3) and Elp1 CKO (orange, 1.13, n=3, p=0.5033). Values for histograms represent mean ± SEM. (G–J) Fluorescent immunohistochemistry on representative horizontal sections through the TG from Control (G and H) or Elp1 CKO (I and J) littermates shows placodal neurons labeled by Isl1 (G and I, blue) or Six1 (H and J, purple) and neural crest cells labeled by Sox10 (G–J, green). Scale bars: 400 µm (B), also applies to C; 20 µm (G), applies to H–J. Refer to Figure 2—source data 1 for quantitative summary data represented in graphs.\nFigure 2—source data 1.Initial trigeminal ganglion (TG) formation appears normal in Elp1 CKO at embryonic day 10.5 (E10.5).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273214-4-elife-71455-fig2.jpg"
} | 009492 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Loss of TrkA neurons with persistent innervation defects in Elp1 CKO at embryonic day 12.5–13 (E12.5–13).(A–H) Representative maximum intensity projections of confocal Z-stacks through Control (A, B, E, and F) or Elp1 CKO (C, D, G, and H) littermates, which were processed for whole-mount immunohistochemistry to detect Tubb3 (A, C, E, and G, white) and TrkA (B, D, F, and H, white), followed by tissue clearing. Arrows indicate regions where nerves are absent or severely diminished in Elp1 CKO (C and G), while arrowheads point to areas with Tubb3-positive nerves but undetectable TrkA expression (C, D, G, and H). (I–P) Fluorescent immunohistochemistry on serial horizontal sections showing TrkA (I–M and O, green), Tubb3 (J and L, purple), or TrkC (N and P, green) in the trigeminal ganglion (I-L) or whisker pad (M–P) of Control (I, J, M, and N) or Elp1 CKO (K, L, O, and P) littermates. Dashed line in F demonstrates the plane of section for M-P. (Q) Quantification of Trk fluorescent signal normalized to Tubb3 fluorescent signal within the trigeminal ganglia of Control (blue, TrkA = 0.897, TrkB = 0.3258, TrkC = 0.3047, n=3) and Elp1 CKO (orange, TrkA = 0.6014, TrkB = 0.3551, TrkC = 0.2783, n=3, p=0.0037 TrkA, 0.4878 for TrkB, 0.7750 for TrkC, nested unpaired t-test with Holm-Sidak adjustment for multiple comparisons). (R) Quantification of Trk-expressing neurons in trigeminal ganglion sections of Control (blue, TrkA = 416.1, TrkB = 98.35, TrkC = 151.6, n=3) and Elp1 CKO (orange, TrkA = 325.0, TrkB = 99.05, TrkC = 154.8, n=3, p=0.0150 for TrkA, 0.8966 for TrkB, 0.7675 for TrkC, nested unpaired t-test with Holm-Sidak adjustment for multiple comparisons). Values for histograms represent mean ± SEM. Scale bars: 200 µm (A), applies to (B–H); 20 µm (I), applies to (J–L) and applies to (M–P) as 25 µm. Refer to Figure 5—source data 1 for quantitative summary data represented in graphs.\nFigure 5—source data 1.Loss of TrkA neurons with persistent innervation defects in Elp1 CKO at embryonic day 12.5–13 (E12.5–13).",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273214-5-elife-71455-fig5.jpg"
} | 009493 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Neural crest-derived trigeminal ganglion neurons are biased to a TrkA fate, while placodal neurons express TrkB or TrkC.(A–D) Representative images of fluorescent immunohistochemistry at embryonic day (E15.5) showing red fluorescent protein (RFP; B–D) with native green fluorescent protein (GFP) fluorescence indicating Wnt1-Cre-mediated recombination (A, C and D) in horizontal sections through the maxillary lobe of the trigeminal ganglion in Wnt1-Cre; ROSAmT/mG reporters. (D) Higher magnification of box in C. Arrowheads point to RFP-positive, non-recombined neurons. (E–G, I–K, and M–O) Fluorescent immunohistochemistry on serial sections through the maxillary lobe of Wnt1-Cre; ROSAmT-mG reporters (n=3) showing TrkA (E and G, white), TrkB (I and K, white), or TrkC (M and O, white) with RFP (F, G, J, K, N, and O, red). Arrowheads point to neurons that express RFP and TrkA (E–G), TrkB (I–K), or TrkC (M–O). (H, L and P) Quantification of the percentage of neurons expressing TrkA (H), TrkB (L), or TrkC (P) that also co-express RFP at E15.5 (n=3). Scale bars: 100 µm (A), applies to (B–C); 20 µm (D); 10 µm (E), applies to (F, G, I–K, and M–O). Refer to Figure 8—source data 1 for quantitative summary data represented in graphs.\nFigure 8—source data 1.Neural crest-derived trigeminal ganglion neurons are biased to a TrkA fate, while placodal neurons express TrkB or TrkC.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273214-6-elife-71455-fig8.jpg"
} | 009494 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Dynamic expression of Six1 and Trk receptors occurs during trigeminal ganglion neurogenesis.(A–I) Fluorescent immunohistochemistry on representative horizontal sections at embryonic day 10.5 (E10.5) (A, D and G), E11.5 (B, E and H), and E12.5 (C, F and I) in Control embryos demonstrating expression of TrkA (A–C, green), TrkB (D–F, green), TrkC (G–I, green), and Six1 (A–I, red). Arrowheads point to neurons that co-express Six1 with TrkA (A–C), TrkB (D–F), or TrkC (G–I). (J) Quantification of the percentage of neurons expressing TrkA (purple), TrkB (green), or TrkC (orange) that also co-express Six1 in the Control trigeminal ganglion at E10.5 (n=2), E11.5 (n=3), and E12.5 (n=3). Data points represent mean ± SEM. Scale bars: 20 µm (A), applies to (B–I). Refer to Figure 6—source data 1 for quantitative summary data represented in graphs.\nFigure 6—source data 1.Dynamic expression of Six1 and Trk receptors occurs during trigeminal ganglion neurogenesis.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273214-7-elife-71455-fig6.jpg"
} | 009495 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "Elp1 protein is enriched in the cytoplasm of developing trigeminal ganglion neurons.(A) Lateral view of embryonic day 10.5 (E10.5) Elp1LacZ reporter mouse stained for β-galactosidase. Dashed line indicates the plane of section for the same embryo shown in B. (B and C) Representative horizontal section through embryo in A to reveal Elp1 gene expression. Boxed region in B is magnified and shown in C. (D–P) Representative horizontal sections taken from Control E10.5 (D–G), E11.5 (H–M), or E12.5 (N–P) mouse embryos followed by fluorescent immunohistochemistry for Elp1 (D–P, green), Islet1 (D, F, H, K and M, ‘Isl1’, purple), Neuropilin 2 (E, ‘Nrp2’, red), β-tubulin III (I, L, M, ‘Tubb3’, red), and Sox10 (N–P, red). Boxed region in D and E is magnified in F–G and shows Elp1 (green), Isl1 (purple), and DAPI-stained nuclei (blue). (J–M) Higher magnification of box in H and I. (O) Higher magnification of box in N. (P) Higher magnification of box in O. Carets indicate Isl1-positive neuronal nuclei (F, G, J–M) and/or Tubb3-positive neuronal cell bodies (J–M). Arrows identify axons (J, L, M, and P), while arrowheads point to Sox10-positive glial progenitors (P). Abbreviations: e: eye; FN: frontonasal prominence; NT: neural tube; ov: otic vesicle; PA: pharyngeal arch; TG: trigeminal ganglion. Scale bars: 400 µm (A), also applies to B; 50 µm (C), applies to D, E, H, and I; 100 µm (N); 10 µm (F), applies to G; 10 µm (J), applies to K, L, and M; 20 µm (O), applies to P as 5 µm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273214-8-elife-71455-fig1.jpg"
} | 009496 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
|
{
"caption": "Illustration of pore formation.Extractions of two successive images of B. sphaericus swimming in a S. aureus biofilm are displayed. The dashed ellipse indicates a zone where a swimmer moves between the two successive images, which creates a pore along its swimming path. Images dimensions are 76 x 78 μm.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273218-1-elife-76513-app1-fig3.jpg"
} | 009497 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "TEM images of the three Bacillus.TEM images of the three Bacillus are acquired, scaled in the same dimension and aligned (left panel). Images at lower scale are made with a zoom in on the flagella insertion (right panel). Note that the zoom in is optical so that the zoomed in image do not correspond to a zone of the larger scale images.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_50-PMC9273218-11-elife-76513-fig2.jpg"
} | 009498 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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{
"caption": "LC3-II puncta per cell in NEFA-treated embryos after 30–48 h of NEFA treatment. Relative percent aggregate of LC3-II per cell (±SD) of 2-cell mouse embryos after exposure to 100 µM PA, 250 µM OA, 100 µM PA and 250 µM OA, or KSOMaa medium alone (control) for 30, 40, and 48 h. Stage-specific embryos from each time point were assessed. n > 3, two-way ANOVA with Tukey’s HSD post hoc test. Significant differences are indicated by *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. A: at the 30-h time point, PA and PA + OA groups resulted in significantly more LC3-II puncta accumulated per cell than OA-alone group [P = 0.0370 (vs. PA); P = 0.0098 (vs. PA + OA)]. B: at the 40-h time point, both PA and PA + OA groups sustained a significantly higher LC3-II puncta aggregation per cell than control [P < 0.0001 (vs. PA); P = 0.0002 (vs. PA + OA)] and OA-alone groups [P < 0.0001 (vs. PA); P = 0.0002 (vs. PA + OA)]. C: after 48 h of NEFA exposure, the PA-alone group resulted in a significantly higher LC3-II puncta count per cell compared with both the OA-alone group (P = 0.0131) and the PA + OA combination group (P = 0.0251). Representative images of LC3-II puncta aggregate after NEFA treatments for 30 (Aii), 40 (Bii), and 48 h (Cii) of exposure. Scale bars = 100 µm. HSD, honestly significant difference; KSOMaa, potassium simplex optimization media with amino acid; LC3, light chain 3; NEFA, nonesterified fatty acid; OA, oleic acid; PA, palmitic acid.",
"subfigure_path": "/datasets/PMC-15M/filtered_biomedica/filtered_v4/subfigures_final/subfig_0_filelist_commercial_batch_124_51-PMC9273280-8-ajpcellp00414p2021_f005.jpg"
} | 009499 | hf://datasets/vector-institute/open-pmc-18m@6109d453e9b8e2de3564869941b2e622faddd8d3/data_00028.tar |
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