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PMC9428249_F2_389527.jpg | What can you see in this picture? | A 56-year-old male patient (Case 10) with a large basilar trunk aneurysm presented with dizziness. Preoperative angiography (A) with 3-dimensional reconstruction (B) demonstrated an irregular dissecting aneurysm at the middle basilar trunk. A single Tubridge device was placed in the basilar trunk (C). 10-month follow-up angiography demonstrated complete obliteration of the aneurysm (D). |
PMC9428251_f3_389537.jpg | What's the most prominent thing you notice in this picture? | Classification of chest computed tomography (CT) in non-tuberculosis patients. (A) Nodular type: ground glass nodules or solid nodules, (B) Pneumonia type: focal or patchy mixed density shadow, and (C) Mixed type: other manifestations such as cavity, cystic or pleural effusion. |
PMC9428251_f3_389532.jpg | What key item or scene is captured in this photo? | Classification of chest computed tomography (CT) in non-tuberculosis patients. (A) Nodular type: ground glass nodules or solid nodules, (B) Pneumonia type: focal or patchy mixed density shadow, and (C) Mixed type: other manifestations such as cavity, cystic or pleural effusion. |
PMC9428251_f3_389531.jpg | What is the core subject represented in this visual? | Classification of chest computed tomography (CT) in non-tuberculosis patients. (A) Nodular type: ground glass nodules or solid nodules, (B) Pneumonia type: focal or patchy mixed density shadow, and (C) Mixed type: other manifestations such as cavity, cystic or pleural effusion. |
PMC9428251_f3_389538.jpg | What does this image primarily show? | Classification of chest computed tomography (CT) in non-tuberculosis patients. (A) Nodular type: ground glass nodules or solid nodules, (B) Pneumonia type: focal or patchy mixed density shadow, and (C) Mixed type: other manifestations such as cavity, cystic or pleural effusion. |
PMC9428256_f1_389539.jpg | What key item or scene is captured in this photo? | Nasopharynx tumors under nasal endoscopy: Nasoendoscopy revealed a left-sided nasopharyngeal mass. |
PMC9428256_f3_389541.jpg | Can you identify the primary element in this image? | Nasal endoscopy combined with external cervical approach to expose tumors: Exposure of the internal carotid artery and tumor resection with safe margins by combined nasal and submandibular approaches. Ethmoid forceps in the nasal approach pulled the mass medially. Arrow: parapharyngeal internal carotid artery. |
PMC9428256_f4_389542.jpg | What is being portrayed in this visual content? | Postoperative field status after tumor resection. The parapharyngeal internal carotid artery dissected through an external cervical approach was visualized by nasendoscopy. Arrow: parapharyngeal internal carotid artery; star: right posterior pharyngeal wall after resection of the nasopharyngeal tumor. |
PMC9428260_f2_389544.jpg | What is the central feature of this picture? |
(A) A 33-year-old female patient had bilateral hypoechoic lesions (arrowhead), which were confirmed as PTMCs by FNAB. (B) After both the PTMCs underwent US-guided PLA, the ablated lesions appeared as well-defined heterogeneous echogenic areas on the grayscale US, with a central hypoechoic ablated needle channel. (C) On the final follow-up, the two ablated lesions were almost completely absorbed, leaving only scar strips (arrowhead). |
PMC9428260_f2_389543.jpg | What key item or scene is captured in this photo? |
(A) A 33-year-old female patient had bilateral hypoechoic lesions (arrowhead), which were confirmed as PTMCs by FNAB. (B) After both the PTMCs underwent US-guided PLA, the ablated lesions appeared as well-defined heterogeneous echogenic areas on the grayscale US, with a central hypoechoic ablated needle channel. (C) On the final follow-up, the two ablated lesions were almost completely absorbed, leaving only scar strips (arrowhead). |
PMC9428260_f2_389547.jpg | What object or scene is depicted here? |
(A) A 33-year-old female patient had bilateral hypoechoic lesions (arrowhead), which were confirmed as PTMCs by FNAB. (B) After both the PTMCs underwent US-guided PLA, the ablated lesions appeared as well-defined heterogeneous echogenic areas on the grayscale US, with a central hypoechoic ablated needle channel. (C) On the final follow-up, the two ablated lesions were almost completely absorbed, leaving only scar strips (arrowhead). |
PMC9428260_f2_389545.jpg | What is the core subject represented in this visual? |
(A) A 33-year-old female patient had bilateral hypoechoic lesions (arrowhead), which were confirmed as PTMCs by FNAB. (B) After both the PTMCs underwent US-guided PLA, the ablated lesions appeared as well-defined heterogeneous echogenic areas on the grayscale US, with a central hypoechoic ablated needle channel. (C) On the final follow-up, the two ablated lesions were almost completely absorbed, leaving only scar strips (arrowhead). |
PMC9428260_f2_389546.jpg | What is being portrayed in this visual content? |
(A) A 33-year-old female patient had bilateral hypoechoic lesions (arrowhead), which were confirmed as PTMCs by FNAB. (B) After both the PTMCs underwent US-guided PLA, the ablated lesions appeared as well-defined heterogeneous echogenic areas on the grayscale US, with a central hypoechoic ablated needle channel. (C) On the final follow-up, the two ablated lesions were almost completely absorbed, leaving only scar strips (arrowhead). |
PMC9428308_F6_389553.jpg | What's the most prominent thing you notice in this picture? | Immunofluorescence diagrams of two IPFP-SCs obtained using the without enzyme method and digestion method after chondrogenic induction. A1 type II collagen produced by the cell matrix after chondrogenic induction of IPFP-SCs using the without enzyme method is positively expressed; type II collagen produced by the cell matrix after chondrogenic induction of IPFP-SCs with B1 enzyme digestion was positively expressed, and all of them showed orange red color. A2 and B2 were nuclear images stained with DAPI, and the nuclei were blue. A3 and B3 were combined images of the corresponding cells. Scale bar = 100 μm. |
PMC9428308_F6_389548.jpg | Can you identify the primary element in this image? | Immunofluorescence diagrams of two IPFP-SCs obtained using the without enzyme method and digestion method after chondrogenic induction. A1 type II collagen produced by the cell matrix after chondrogenic induction of IPFP-SCs using the without enzyme method is positively expressed; type II collagen produced by the cell matrix after chondrogenic induction of IPFP-SCs with B1 enzyme digestion was positively expressed, and all of them showed orange red color. A2 and B2 were nuclear images stained with DAPI, and the nuclei were blue. A3 and B3 were combined images of the corresponding cells. Scale bar = 100 μm. |
PMC9428308_F6_389551.jpg | What is the core subject represented in this visual? | Immunofluorescence diagrams of two IPFP-SCs obtained using the without enzyme method and digestion method after chondrogenic induction. A1 type II collagen produced by the cell matrix after chondrogenic induction of IPFP-SCs using the without enzyme method is positively expressed; type II collagen produced by the cell matrix after chondrogenic induction of IPFP-SCs with B1 enzyme digestion was positively expressed, and all of them showed orange red color. A2 and B2 were nuclear images stained with DAPI, and the nuclei were blue. A3 and B3 were combined images of the corresponding cells. Scale bar = 100 μm. |
PMC9428308_F6_389550.jpg | What object or scene is depicted here? | Immunofluorescence diagrams of two IPFP-SCs obtained using the without enzyme method and digestion method after chondrogenic induction. A1 type II collagen produced by the cell matrix after chondrogenic induction of IPFP-SCs using the without enzyme method is positively expressed; type II collagen produced by the cell matrix after chondrogenic induction of IPFP-SCs with B1 enzyme digestion was positively expressed, and all of them showed orange red color. A2 and B2 were nuclear images stained with DAPI, and the nuclei were blue. A3 and B3 were combined images of the corresponding cells. Scale bar = 100 μm. |
PMC9428308_F6_389549.jpg | What's the most prominent thing you notice in this picture? | Immunofluorescence diagrams of two IPFP-SCs obtained using the without enzyme method and digestion method after chondrogenic induction. A1 type II collagen produced by the cell matrix after chondrogenic induction of IPFP-SCs using the without enzyme method is positively expressed; type II collagen produced by the cell matrix after chondrogenic induction of IPFP-SCs with B1 enzyme digestion was positively expressed, and all of them showed orange red color. A2 and B2 were nuclear images stained with DAPI, and the nuclei were blue. A3 and B3 were combined images of the corresponding cells. Scale bar = 100 μm. |
PMC9428308_F6_389552.jpg | What is the main focus of this visual representation? | Immunofluorescence diagrams of two IPFP-SCs obtained using the without enzyme method and digestion method after chondrogenic induction. A1 type II collagen produced by the cell matrix after chondrogenic induction of IPFP-SCs using the without enzyme method is positively expressed; type II collagen produced by the cell matrix after chondrogenic induction of IPFP-SCs with B1 enzyme digestion was positively expressed, and all of them showed orange red color. A2 and B2 were nuclear images stained with DAPI, and the nuclei were blue. A3 and B3 were combined images of the corresponding cells. Scale bar = 100 μm. |
PMC9428316_F2_389558.jpg | Can you identify the primary element in this image? | (A,B) Color photography of the right eye before surgery showed cataract and a significantly deepened anterior chamber. (C) Photographs of the right eyes by slit-lamp microscopy at 1 year after surgery at our hospital. The IOL was stably positioned in the eye. (D) Photographs of the left eyes by slit-lamp microscopy at 1 year after the right eye surgery at our hospital. The left iris pigment was dispersed. (E,F) Ultrasound biomicrographs of the right eye before (E) and after (F) surgery at our hospital. Panel (E) showed a deep anterior chamber and elongated zonular fibers. The panel (F) revealed the IOL to be centrally located in the eye after surgery. (G,H) Aberrometry using the iTrace system, showing visual quality in the right eye (G) and left eye (H) after right eye surgery at our hospital. |
PMC9428316_F2_389554.jpg | What is shown in this image? | (A,B) Color photography of the right eye before surgery showed cataract and a significantly deepened anterior chamber. (C) Photographs of the right eyes by slit-lamp microscopy at 1 year after surgery at our hospital. The IOL was stably positioned in the eye. (D) Photographs of the left eyes by slit-lamp microscopy at 1 year after the right eye surgery at our hospital. The left iris pigment was dispersed. (E,F) Ultrasound biomicrographs of the right eye before (E) and after (F) surgery at our hospital. Panel (E) showed a deep anterior chamber and elongated zonular fibers. The panel (F) revealed the IOL to be centrally located in the eye after surgery. (G,H) Aberrometry using the iTrace system, showing visual quality in the right eye (G) and left eye (H) after right eye surgery at our hospital. |
PMC9428316_F2_389561.jpg | What object or scene is depicted here? | (A,B) Color photography of the right eye before surgery showed cataract and a significantly deepened anterior chamber. (C) Photographs of the right eyes by slit-lamp microscopy at 1 year after surgery at our hospital. The IOL was stably positioned in the eye. (D) Photographs of the left eyes by slit-lamp microscopy at 1 year after the right eye surgery at our hospital. The left iris pigment was dispersed. (E,F) Ultrasound biomicrographs of the right eye before (E) and after (F) surgery at our hospital. Panel (E) showed a deep anterior chamber and elongated zonular fibers. The panel (F) revealed the IOL to be centrally located in the eye after surgery. (G,H) Aberrometry using the iTrace system, showing visual quality in the right eye (G) and left eye (H) after right eye surgery at our hospital. |
PMC9428316_F2_389555.jpg | What is the principal component of this image? | (A,B) Color photography of the right eye before surgery showed cataract and a significantly deepened anterior chamber. (C) Photographs of the right eyes by slit-lamp microscopy at 1 year after surgery at our hospital. The IOL was stably positioned in the eye. (D) Photographs of the left eyes by slit-lamp microscopy at 1 year after the right eye surgery at our hospital. The left iris pigment was dispersed. (E,F) Ultrasound biomicrographs of the right eye before (E) and after (F) surgery at our hospital. Panel (E) showed a deep anterior chamber and elongated zonular fibers. The panel (F) revealed the IOL to be centrally located in the eye after surgery. (G,H) Aberrometry using the iTrace system, showing visual quality in the right eye (G) and left eye (H) after right eye surgery at our hospital. |
PMC9428316_F2_389557.jpg | What's the most prominent thing you notice in this picture? | (A,B) Color photography of the right eye before surgery showed cataract and a significantly deepened anterior chamber. (C) Photographs of the right eyes by slit-lamp microscopy at 1 year after surgery at our hospital. The IOL was stably positioned in the eye. (D) Photographs of the left eyes by slit-lamp microscopy at 1 year after the right eye surgery at our hospital. The left iris pigment was dispersed. (E,F) Ultrasound biomicrographs of the right eye before (E) and after (F) surgery at our hospital. Panel (E) showed a deep anterior chamber and elongated zonular fibers. The panel (F) revealed the IOL to be centrally located in the eye after surgery. (G,H) Aberrometry using the iTrace system, showing visual quality in the right eye (G) and left eye (H) after right eye surgery at our hospital. |
PMC9428339_F1_389568.jpg | What is the main focus of this visual representation? | At the first illness, on T1-weighted and T2-weighted images, the tumor revealed long signal abnormal signals (A,B). In FLAIR, it was an iso-low signal (C). DWI showed a low-signal tumor (D). Contrast-enhanced MRI images showed a markedly enhanced mass (E–G). |
PMC9428339_F1_389564.jpg | What is the central feature of this picture? | At the first illness, on T1-weighted and T2-weighted images, the tumor revealed long signal abnormal signals (A,B). In FLAIR, it was an iso-low signal (C). DWI showed a low-signal tumor (D). Contrast-enhanced MRI images showed a markedly enhanced mass (E–G). |
PMC9428339_F1_389567.jpg | What is the principal component of this image? | At the first illness, on T1-weighted and T2-weighted images, the tumor revealed long signal abnormal signals (A,B). In FLAIR, it was an iso-low signal (C). DWI showed a low-signal tumor (D). Contrast-enhanced MRI images showed a markedly enhanced mass (E–G). |
PMC9428339_F1_389563.jpg | What stands out most in this visual? | At the first illness, on T1-weighted and T2-weighted images, the tumor revealed long signal abnormal signals (A,B). In FLAIR, it was an iso-low signal (C). DWI showed a low-signal tumor (D). Contrast-enhanced MRI images showed a markedly enhanced mass (E–G). |
PMC9428339_F1_389562.jpg | What is the dominant medical problem in this image? | At the first illness, on T1-weighted and T2-weighted images, the tumor revealed long signal abnormal signals (A,B). In FLAIR, it was an iso-low signal (C). DWI showed a low-signal tumor (D). Contrast-enhanced MRI images showed a markedly enhanced mass (E–G). |
PMC9428339_F1_389566.jpg | What stands out most in this visual? | At the first illness, on T1-weighted and T2-weighted images, the tumor revealed long signal abnormal signals (A,B). In FLAIR, it was an iso-low signal (C). DWI showed a low-signal tumor (D). Contrast-enhanced MRI images showed a markedly enhanced mass (E–G). |
PMC9428339_F1_389565.jpg | Describe the main subject of this image. | At the first illness, on T1-weighted and T2-weighted images, the tumor revealed long signal abnormal signals (A,B). In FLAIR, it was an iso-low signal (C). DWI showed a low-signal tumor (D). Contrast-enhanced MRI images showed a markedly enhanced mass (E–G). |
PMC9428339_F3_389572.jpg | What key item or scene is captured in this photo? | One year after the first operation, the CT scan showed multiple cystic bone destructions around the original cranial repair site (A–C). Around the repaired skull, the tumor revealed long signal abnormal signals on T1-weighted and T2-weighted images (D,E). In FLAIR, it was an iso-low signal (F). Contrast-enhanced MRI images also showed a markedly enhanced mass (E–G). |
PMC9428339_F3_389574.jpg | What is the core subject represented in this visual? | One year after the first operation, the CT scan showed multiple cystic bone destructions around the original cranial repair site (A–C). Around the repaired skull, the tumor revealed long signal abnormal signals on T1-weighted and T2-weighted images (D,E). In FLAIR, it was an iso-low signal (F). Contrast-enhanced MRI images also showed a markedly enhanced mass (E–G). |
PMC9428339_F3_389576.jpg | What's the most prominent thing you notice in this picture? | One year after the first operation, the CT scan showed multiple cystic bone destructions around the original cranial repair site (A–C). Around the repaired skull, the tumor revealed long signal abnormal signals on T1-weighted and T2-weighted images (D,E). In FLAIR, it was an iso-low signal (F). Contrast-enhanced MRI images also showed a markedly enhanced mass (E–G). |
PMC9428339_F3_389573.jpg | What is shown in this image? | One year after the first operation, the CT scan showed multiple cystic bone destructions around the original cranial repair site (A–C). Around the repaired skull, the tumor revealed long signal abnormal signals on T1-weighted and T2-weighted images (D,E). In FLAIR, it was an iso-low signal (F). Contrast-enhanced MRI images also showed a markedly enhanced mass (E–G). |
PMC9428339_F3_389570.jpg | What is shown in this image? | One year after the first operation, the CT scan showed multiple cystic bone destructions around the original cranial repair site (A–C). Around the repaired skull, the tumor revealed long signal abnormal signals on T1-weighted and T2-weighted images (D,E). In FLAIR, it was an iso-low signal (F). Contrast-enhanced MRI images also showed a markedly enhanced mass (E–G). |
PMC9428339_F3_389577.jpg | What is the focal point of this photograph? | One year after the first operation, the CT scan showed multiple cystic bone destructions around the original cranial repair site (A–C). Around the repaired skull, the tumor revealed long signal abnormal signals on T1-weighted and T2-weighted images (D,E). In FLAIR, it was an iso-low signal (F). Contrast-enhanced MRI images also showed a markedly enhanced mass (E–G). |
PMC9428339_F3_389571.jpg | What is the main focus of this visual representation? | One year after the first operation, the CT scan showed multiple cystic bone destructions around the original cranial repair site (A–C). Around the repaired skull, the tumor revealed long signal abnormal signals on T1-weighted and T2-weighted images (D,E). In FLAIR, it was an iso-low signal (F). Contrast-enhanced MRI images also showed a markedly enhanced mass (E–G). |
PMC9428339_F3_389569.jpg | What's the most prominent thing you notice in this picture? | One year after the first operation, the CT scan showed multiple cystic bone destructions around the original cranial repair site (A–C). Around the repaired skull, the tumor revealed long signal abnormal signals on T1-weighted and T2-weighted images (D,E). In FLAIR, it was an iso-low signal (F). Contrast-enhanced MRI images also showed a markedly enhanced mass (E–G). |
PMC9428341_F1_389578.jpg | What is the main focus of this visual representation? | X-ray (front) showed clear calcific deposits in the target shoulder. |
PMC9428341_F2_389581.jpg | What is the core subject represented in this visual? | MRI showed the calcific deposits in the target shoulder in in the (A) oblique coronal; (B) sagittal; and (C) horizontal plane. |
PMC9428341_F2_389579.jpg | What is being portrayed in this visual content? | MRI showed the calcific deposits in the target shoulder in in the (A) oblique coronal; (B) sagittal; and (C) horizontal plane. |
PMC9428341_F2_389580.jpg | What is the principal component of this image? | MRI showed the calcific deposits in the target shoulder in in the (A) oblique coronal; (B) sagittal; and (C) horizontal plane. |
PMC9428362_fig2_389582.jpg | What is being portrayed in this visual content? | Examples of PMNs, macrophages, and foreign body giant cells (FBGCs). (1) PMNs are distinguishable due to their multilobed nucleus and eosinophilic cytoplasm. (2) Macrophages have a basophilic cytoplasm and a bean-shaped or ovoid nucleus. (3) FBGCs are large clusters of fused macrophages. The image was taken at 400× magnification. |
PMC9428362_fig8_389584.jpg | Describe the main subject of this image. | BrdU staining. (A) At POD 1, a limited amount of proliferation was noted in the conjunctiva (arrow), and no proliferation was seen around the implant site. (B) Increased proliferation was visible around the conjunctiva; additionally, the conjunctival layer was increased at POD 5. (C) A limited amount of proliferation was visible around the implant site at POD 5. (D) POD 40 revealed relatively low proliferation in the conjunctiva; however, around the implant site more proliferating cells were visible. *Position of SIBS microshunt. Images were taken at 200× magnification. |
PMC9428384_Fig4_389593.jpg | What is being portrayed in this visual content? | Horizontal transmission of LbBV1 from Leptosphaeria biglobosa strain GZJS19 to strain Lb731 by using pairing culture technique.The mycelium in the area of the dashed box were picked out to establish the derivative strains. The colony morphology (23 °C, 14 days) on potato dextrose agar of eight derivative strains used for biological property assays. |
PMC9428384_Fig4_389592.jpg | What is the core subject represented in this visual? | Horizontal transmission of LbBV1 from Leptosphaeria biglobosa strain GZJS19 to strain Lb731 by using pairing culture technique.The mycelium in the area of the dashed box were picked out to establish the derivative strains. The colony morphology (23 °C, 14 days) on potato dextrose agar of eight derivative strains used for biological property assays. |
PMC9428384_Fig4_389589.jpg | What is being portrayed in this visual content? | Horizontal transmission of LbBV1 from Leptosphaeria biglobosa strain GZJS19 to strain Lb731 by using pairing culture technique.The mycelium in the area of the dashed box were picked out to establish the derivative strains. The colony morphology (23 °C, 14 days) on potato dextrose agar of eight derivative strains used for biological property assays. |
PMC9428384_Fig4_389590.jpg | What can you see in this picture? | Horizontal transmission of LbBV1 from Leptosphaeria biglobosa strain GZJS19 to strain Lb731 by using pairing culture technique.The mycelium in the area of the dashed box were picked out to establish the derivative strains. The colony morphology (23 °C, 14 days) on potato dextrose agar of eight derivative strains used for biological property assays. |
PMC9428384_Fig4_389591.jpg | Can you identify the primary element in this image? | Horizontal transmission of LbBV1 from Leptosphaeria biglobosa strain GZJS19 to strain Lb731 by using pairing culture technique.The mycelium in the area of the dashed box were picked out to establish the derivative strains. The colony morphology (23 °C, 14 days) on potato dextrose agar of eight derivative strains used for biological property assays. |
PMC9428384_Fig4_389588.jpg | What can you see in this picture? | Horizontal transmission of LbBV1 from Leptosphaeria biglobosa strain GZJS19 to strain Lb731 by using pairing culture technique.The mycelium in the area of the dashed box were picked out to establish the derivative strains. The colony morphology (23 °C, 14 days) on potato dextrose agar of eight derivative strains used for biological property assays. |
PMC9428384_Fig4_389594.jpg | What is shown in this image? | Horizontal transmission of LbBV1 from Leptosphaeria biglobosa strain GZJS19 to strain Lb731 by using pairing culture technique.The mycelium in the area of the dashed box were picked out to establish the derivative strains. The colony morphology (23 °C, 14 days) on potato dextrose agar of eight derivative strains used for biological property assays. |
PMC9428384_Fig4_389587.jpg | What is being portrayed in this visual content? | Horizontal transmission of LbBV1 from Leptosphaeria biglobosa strain GZJS19 to strain Lb731 by using pairing culture technique.The mycelium in the area of the dashed box were picked out to establish the derivative strains. The colony morphology (23 °C, 14 days) on potato dextrose agar of eight derivative strains used for biological property assays. |
PMC9428384_Fig6_389595.jpg | What does this image primarily show? | Biological effects of Leptosphaeria biglobosa botybirnavirus 1 (LbBV1) on Botrytis cinerea strain t-459.a RT-PCR detection of dsRNA-1/dsRNA-2 presence in t-459-V with specific primers. b Agarose gel electrophoresis and northern blotting detection of dsRNAs extracted from the mycelia of L. biglobosa strains (GZJS19 and GZJS19-VF) and B. cinerea strains (t-459-V and t-459). c RT-PCR detection of the presence of dsRNA-1/dsRNA-2 in L. biglobosa and B. cinerea strains obtained from the co-culture and co-inoculation tests of L. biglobosa strain GZJS19 and B. cinerea strain t-459. The identities of these strains were confirmed by using PCR with species-specific primers, Bc = B. cinerea, Lb = L. biglobosa. Marker, DNA marker D10000 (TaKaRa). d Pathogenicity assay (20 °C, 3 days) of strains t-459 and t-459-V on detached Nicotiana benthamiana leaves. e Lesion diameter (20 °C, 3 days, lower) on detached N. benthamiana leaves of strains t-459 and t-459-V. “**” indicates a significant difference (p < 0.01) between strains t-459 and t-459-V in pathogenicity. f Colony morphology (20 °C, 20 days) of strains t-459 and t-459-V on potato dextrose agar (PDA). g Radial mycelial growth rate (20 °C, upper) of strains t-459 and t-459-V on PDA. |
PMC9428384_Fig6_389597.jpg | What object or scene is depicted here? | Biological effects of Leptosphaeria biglobosa botybirnavirus 1 (LbBV1) on Botrytis cinerea strain t-459.a RT-PCR detection of dsRNA-1/dsRNA-2 presence in t-459-V with specific primers. b Agarose gel electrophoresis and northern blotting detection of dsRNAs extracted from the mycelia of L. biglobosa strains (GZJS19 and GZJS19-VF) and B. cinerea strains (t-459-V and t-459). c RT-PCR detection of the presence of dsRNA-1/dsRNA-2 in L. biglobosa and B. cinerea strains obtained from the co-culture and co-inoculation tests of L. biglobosa strain GZJS19 and B. cinerea strain t-459. The identities of these strains were confirmed by using PCR with species-specific primers, Bc = B. cinerea, Lb = L. biglobosa. Marker, DNA marker D10000 (TaKaRa). d Pathogenicity assay (20 °C, 3 days) of strains t-459 and t-459-V on detached Nicotiana benthamiana leaves. e Lesion diameter (20 °C, 3 days, lower) on detached N. benthamiana leaves of strains t-459 and t-459-V. “**” indicates a significant difference (p < 0.01) between strains t-459 and t-459-V in pathogenicity. f Colony morphology (20 °C, 20 days) of strains t-459 and t-459-V on potato dextrose agar (PDA). g Radial mycelial growth rate (20 °C, upper) of strains t-459 and t-459-V on PDA. |
PMC9428392_F1_389601.jpg | What's the most prominent thing you notice in this picture? | Abdominal vascular computed tomography (CT) angiography revealed atherosclerotic changes in the lower abdominal aorta, bilateral common iliac arteries, and internal iliac arteries, with corresponding mild stenosis and extensive calcification of the venous network in the ascending and transverse parts of the colon (arrow). |
PMC9428392_F1_389602.jpg | What stands out most in this visual? | Abdominal vascular computed tomography (CT) angiography revealed atherosclerotic changes in the lower abdominal aorta, bilateral common iliac arteries, and internal iliac arteries, with corresponding mild stenosis and extensive calcification of the venous network in the ascending and transverse parts of the colon (arrow). |
PMC9428392_F2_389606.jpg | What object or scene is depicted here? | Abdominal CT and enhanced CT revealed extensive calcification of the venous network in the ascending colon and transverse colon, with edema and thickening of the intestinal wall and small intestinal obstruction. |
PMC9428392_F2_389603.jpg | What can you see in this picture? | Abdominal CT and enhanced CT revealed extensive calcification of the venous network in the ascending colon and transverse colon, with edema and thickening of the intestinal wall and small intestinal obstruction. |
PMC9428392_F2_389605.jpg | What is the dominant medical problem in this image? | Abdominal CT and enhanced CT revealed extensive calcification of the venous network in the ascending colon and transverse colon, with edema and thickening of the intestinal wall and small intestinal obstruction. |
PMC9428397_F1_389610.jpg | What is the principal component of this image? | Features of the tumor. (A) Right neck ultrasonography shows a hypo-echoic region with abundant blood flow surrounding the right common carotid artery, which has normal internal blood flow. White arrow indicates the right common carotid artery. (B) The trunk positron emission tomography/computed tomography shows a large mass in the right neck surrounding the adjacent large vessels, which had a non-uniform increase in radioactive uptake. Red arrow indicates the tumor. |
PMC9428397_F1_389609.jpg | What is shown in this image? | Features of the tumor. (A) Right neck ultrasonography shows a hypo-echoic region with abundant blood flow surrounding the right common carotid artery, which has normal internal blood flow. White arrow indicates the right common carotid artery. (B) The trunk positron emission tomography/computed tomography shows a large mass in the right neck surrounding the adjacent large vessels, which had a non-uniform increase in radioactive uptake. Red arrow indicates the tumor. |
PMC9428397_F1_389611.jpg | What stands out most in this visual? | Features of the tumor. (A) Right neck ultrasonography shows a hypo-echoic region with abundant blood flow surrounding the right common carotid artery, which has normal internal blood flow. White arrow indicates the right common carotid artery. (B) The trunk positron emission tomography/computed tomography shows a large mass in the right neck surrounding the adjacent large vessels, which had a non-uniform increase in radioactive uptake. Red arrow indicates the tumor. |
PMC9428397_F1_389608.jpg | Describe the main subject of this image. | Features of the tumor. (A) Right neck ultrasonography shows a hypo-echoic region with abundant blood flow surrounding the right common carotid artery, which has normal internal blood flow. White arrow indicates the right common carotid artery. (B) The trunk positron emission tomography/computed tomography shows a large mass in the right neck surrounding the adjacent large vessels, which had a non-uniform increase in radioactive uptake. Red arrow indicates the tumor. |
PMC9428397_F2_389613.jpg | What key item or scene is captured in this photo? | Left inguinal lymph node biopsy shows diffuse large B-cell lymphoma. (A) Large, round, or ovoid tumor cells are seen, with some cells having an irregularly shaped nuclear membrane. Single large or multiple small nucleoli can be seen in the tumor cells, and nuclear division is more common (H and E, × 200). (B) Immunohistochemistry stain of CD 20 shows the tumor cells were uniformly and strongly positive (× 200). (C) Immunohistochemistry stain of CD 3 shows the tumor cells are negative, but the T lymphocytes in the background are positive (× 200). Black arrow indicates the tumor cell. White arrow indicates the T lymphocyte. |
PMC9428397_F2_389614.jpg | What does this image primarily show? | Left inguinal lymph node biopsy shows diffuse large B-cell lymphoma. (A) Large, round, or ovoid tumor cells are seen, with some cells having an irregularly shaped nuclear membrane. Single large or multiple small nucleoli can be seen in the tumor cells, and nuclear division is more common (H and E, × 200). (B) Immunohistochemistry stain of CD 20 shows the tumor cells were uniformly and strongly positive (× 200). (C) Immunohistochemistry stain of CD 3 shows the tumor cells are negative, but the T lymphocytes in the background are positive (× 200). Black arrow indicates the tumor cell. White arrow indicates the T lymphocyte. |
PMC9428397_F2_389615.jpg | What stands out most in this visual? | Left inguinal lymph node biopsy shows diffuse large B-cell lymphoma. (A) Large, round, or ovoid tumor cells are seen, with some cells having an irregularly shaped nuclear membrane. Single large or multiple small nucleoli can be seen in the tumor cells, and nuclear division is more common (H and E, × 200). (B) Immunohistochemistry stain of CD 20 shows the tumor cells were uniformly and strongly positive (× 200). (C) Immunohistochemistry stain of CD 3 shows the tumor cells are negative, but the T lymphocytes in the background are positive (× 200). Black arrow indicates the tumor cell. White arrow indicates the T lymphocyte. |
PMC9428397_F3_389617.jpg | What is the principal component of this image? | The trunk positron emission tomography/computed tomography shows significant shrinkage of the original large mass in the right neck after four cycles of immunochemotherapy. (A) After immunochemotherapy for four cycles. (B) Before the immunochemotherapy. Red arrow indicates the tumor. |
PMC9428397_F3_389618.jpg | What stands out most in this visual? | The trunk positron emission tomography/computed tomography shows significant shrinkage of the original large mass in the right neck after four cycles of immunochemotherapy. (A) After immunochemotherapy for four cycles. (B) Before the immunochemotherapy. Red arrow indicates the tumor. |
PMC9428397_F3_389621.jpg | What is the principal component of this image? | The trunk positron emission tomography/computed tomography shows significant shrinkage of the original large mass in the right neck after four cycles of immunochemotherapy. (A) After immunochemotherapy for four cycles. (B) Before the immunochemotherapy. Red arrow indicates the tumor. |
PMC9428397_F3_389619.jpg | What's the most prominent thing you notice in this picture? | The trunk positron emission tomography/computed tomography shows significant shrinkage of the original large mass in the right neck after four cycles of immunochemotherapy. (A) After immunochemotherapy for four cycles. (B) Before the immunochemotherapy. Red arrow indicates the tumor. |
PMC9428397_F3_389616.jpg | What is the focal point of this photograph? | The trunk positron emission tomography/computed tomography shows significant shrinkage of the original large mass in the right neck after four cycles of immunochemotherapy. (A) After immunochemotherapy for four cycles. (B) Before the immunochemotherapy. Red arrow indicates the tumor. |
PMC9428407_F5_389624.jpg | What object or scene is depicted here? | Iron accumulation in the vascular tissues of lpr1lpr2 double mutant. (A–C) Perls/DAB staining of Col-0 and lpr1lpr2. (A) Close-up views of roots. (B) Leaves from different positions. OL, old leaf; ML, middle leaf; YL, young leaf. (C) Cross sections of old leaves (left) and close-up views of vascular vessels (right). X, xylem; P, phloem; S, sclerenchyma. (D–F) Turnbull staining of Col-0 and lpr1lpr2. (D) Close-up views of roots. (E) Leaves from different positions. (F) Cross sections of old leaves and close-up views of vascular vessels. Col-0 and lpr1lpr2 were precultured in low-Fe (0.2 μM) nutrient solution for 3 weeks and transferred to Fe-sufficient (50 μM) nutrient solution for another 7 days. Scale bars 200 μm in panels (A,C, left), (D,F, left); 50 μm in panels (C, right), (F, right); 1,000 μm in panels (B,E). |
PMC9428407_F5_389625.jpg | What stands out most in this visual? | Iron accumulation in the vascular tissues of lpr1lpr2 double mutant. (A–C) Perls/DAB staining of Col-0 and lpr1lpr2. (A) Close-up views of roots. (B) Leaves from different positions. OL, old leaf; ML, middle leaf; YL, young leaf. (C) Cross sections of old leaves (left) and close-up views of vascular vessels (right). X, xylem; P, phloem; S, sclerenchyma. (D–F) Turnbull staining of Col-0 and lpr1lpr2. (D) Close-up views of roots. (E) Leaves from different positions. (F) Cross sections of old leaves and close-up views of vascular vessels. Col-0 and lpr1lpr2 were precultured in low-Fe (0.2 μM) nutrient solution for 3 weeks and transferred to Fe-sufficient (50 μM) nutrient solution for another 7 days. Scale bars 200 μm in panels (A,C, left), (D,F, left); 50 μm in panels (C, right), (F, right); 1,000 μm in panels (B,E). |
PMC9428440_F1_389630.jpg | What does this image primarily show? | Venous phase of computed tomography (CT) angiography images (A,B) showing a left renal tumor (RT) with renal vein (arrowheads) and inferior cava vein tumor thrombus (arrows) extending into the right atrium (asterisk). |
PMC9428440_F1_389631.jpg | What is the main focus of this visual representation? | Venous phase of computed tomography (CT) angiography images (A,B) showing a left renal tumor (RT) with renal vein (arrowheads) and inferior cava vein tumor thrombus (arrows) extending into the right atrium (asterisk). |
PMC9428446_f3_389632.jpg | What is shown in this image? | Efficacy of the combination of Sorafenib plus CT011 with lymphodepletion. (A), Changes of the AFP after Sorafenib monotherapy and the initiation of GPC3-CAR T infusion; (B), Changes of the No.3 target lesion. CT scans showed this target lesion was about 16.76 mm at baseline and regressed gradually after the combination treatment. At 9th month, this lesion completely disappeared without relapse; (C), The postoperative pathology picture of the No.4 target lesion at 12th month (HE×100 and HE×200, the pictures showed large patch of coagulative necrosis, peripheral fibrosis, chronic inflammatory cell infiltration, no obvious tumor residue, indicating reaction post anti-tumor treatment); (D), Positron emission tomography-computed tomography (PET-CT) images of the target lesions. The patient received PET-CT check at baseline, 9 months, 12 months, and 16 months post first infusion. No.1, No.2 and No.3 target lesions disappeared at the 12th month, while No.4 target lesion was inactive and was considered as non-specific uptake after anti-tumor treatment. |
PMC9428446_f3_389633.jpg | What does this image primarily show? | Efficacy of the combination of Sorafenib plus CT011 with lymphodepletion. (A), Changes of the AFP after Sorafenib monotherapy and the initiation of GPC3-CAR T infusion; (B), Changes of the No.3 target lesion. CT scans showed this target lesion was about 16.76 mm at baseline and regressed gradually after the combination treatment. At 9th month, this lesion completely disappeared without relapse; (C), The postoperative pathology picture of the No.4 target lesion at 12th month (HE×100 and HE×200, the pictures showed large patch of coagulative necrosis, peripheral fibrosis, chronic inflammatory cell infiltration, no obvious tumor residue, indicating reaction post anti-tumor treatment); (D), Positron emission tomography-computed tomography (PET-CT) images of the target lesions. The patient received PET-CT check at baseline, 9 months, 12 months, and 16 months post first infusion. No.1, No.2 and No.3 target lesions disappeared at the 12th month, while No.4 target lesion was inactive and was considered as non-specific uptake after anti-tumor treatment. |
PMC9428446_f3_389635.jpg | What object or scene is depicted here? | Efficacy of the combination of Sorafenib plus CT011 with lymphodepletion. (A), Changes of the AFP after Sorafenib monotherapy and the initiation of GPC3-CAR T infusion; (B), Changes of the No.3 target lesion. CT scans showed this target lesion was about 16.76 mm at baseline and regressed gradually after the combination treatment. At 9th month, this lesion completely disappeared without relapse; (C), The postoperative pathology picture of the No.4 target lesion at 12th month (HE×100 and HE×200, the pictures showed large patch of coagulative necrosis, peripheral fibrosis, chronic inflammatory cell infiltration, no obvious tumor residue, indicating reaction post anti-tumor treatment); (D), Positron emission tomography-computed tomography (PET-CT) images of the target lesions. The patient received PET-CT check at baseline, 9 months, 12 months, and 16 months post first infusion. No.1, No.2 and No.3 target lesions disappeared at the 12th month, while No.4 target lesion was inactive and was considered as non-specific uptake after anti-tumor treatment. |
PMC9428461_F3_389636.jpg | What is the dominant medical problem in this image? | Photograph of mortars of different samples of Tunisian sulfate-resisting Portland cement conserved for 2 years in 10 g/L Na2SO4 and 10 g/L MgSO4 (Labidi et al., 2019a). |
PMC9428461_F3_389638.jpg | What stands out most in this visual? | Photograph of mortars of different samples of Tunisian sulfate-resisting Portland cement conserved for 2 years in 10 g/L Na2SO4 and 10 g/L MgSO4 (Labidi et al., 2019a). |
PMC9428461_F3_389639.jpg | What is the core subject represented in this visual? | Photograph of mortars of different samples of Tunisian sulfate-resisting Portland cement conserved for 2 years in 10 g/L Na2SO4 and 10 g/L MgSO4 (Labidi et al., 2019a). |
PMC9428461_F3_389640.jpg | What is the core subject represented in this visual? | Photograph of mortars of different samples of Tunisian sulfate-resisting Portland cement conserved for 2 years in 10 g/L Na2SO4 and 10 g/L MgSO4 (Labidi et al., 2019a). |
PMC9428461_F3_389637.jpg | What stands out most in this visual? | Photograph of mortars of different samples of Tunisian sulfate-resisting Portland cement conserved for 2 years in 10 g/L Na2SO4 and 10 g/L MgSO4 (Labidi et al., 2019a). |
PMC9428461_F3_389641.jpg | What is the dominant medical problem in this image? | Photograph of mortars of different samples of Tunisian sulfate-resisting Portland cement conserved for 2 years in 10 g/L Na2SO4 and 10 g/L MgSO4 (Labidi et al., 2019a). |
PMC9428462_F5_389644.jpg | What is the principal component of this image? | Visualization of activated neutrophils in the heart of wild type (WT) and CD36 null (CD36–/–) mice. (A) Neutrophils are visualized non-invasively using 64Cu-AMD3100 tracer and PET/CT scanning. (B) Quantification of 64Cu-AMD3100 tracer in the heart (n = 10 in WT mice, n = 7 in CD36–/– mice). (C)
Ex vivo autoradiography of heart slices collected from WT and CD36–/– mice immediately after the PET scan to further document uptake of 64Cu-AMD3100 (n = 2/group). (D) Flow cytometric analysis of CXCR4 expression on cardiac neutrophils isolated from WT and CD36–/– mice (n = 3/group). All data are means ± SE with n representing the number of mice per group. Statistical significance is determined by the unpaired non-parametric Mann–Whitney t-test. *p < 0.05. |
PMC9428462_F5_389643.jpg | What is the core subject represented in this visual? | Visualization of activated neutrophils in the heart of wild type (WT) and CD36 null (CD36–/–) mice. (A) Neutrophils are visualized non-invasively using 64Cu-AMD3100 tracer and PET/CT scanning. (B) Quantification of 64Cu-AMD3100 tracer in the heart (n = 10 in WT mice, n = 7 in CD36–/– mice). (C)
Ex vivo autoradiography of heart slices collected from WT and CD36–/– mice immediately after the PET scan to further document uptake of 64Cu-AMD3100 (n = 2/group). (D) Flow cytometric analysis of CXCR4 expression on cardiac neutrophils isolated from WT and CD36–/– mice (n = 3/group). All data are means ± SE with n representing the number of mice per group. Statistical significance is determined by the unpaired non-parametric Mann–Whitney t-test. *p < 0.05. |
PMC9428462_F6_389651.jpg | What can you see in this picture? | 68Ga-DOTA-ECL1i PET/CT imaging the infiltration of CCR2 + monocyte/macrophages in hearts. (A,B) Representative 68Ga-DOTA-ECL1i PET/CT images and quantitative analysis showed higher tracer accumulation in the heart of CD36–/– (n = 5) compared with WT mice (n = 5) and CCR2–/– mice (n = 4/group). (C) Flow cytometric analysis of CCR2 expression in macrophages isolated from WT and CD36–/– hearts (n = 3/group). All data are means ± SE with n representing the number of mice per group. Statistical significance is determined by One-way ANOVA. *p < 0.05. |
PMC9428462_F6_389650.jpg | What is shown in this image? | 68Ga-DOTA-ECL1i PET/CT imaging the infiltration of CCR2 + monocyte/macrophages in hearts. (A,B) Representative 68Ga-DOTA-ECL1i PET/CT images and quantitative analysis showed higher tracer accumulation in the heart of CD36–/– (n = 5) compared with WT mice (n = 5) and CCR2–/– mice (n = 4/group). (C) Flow cytometric analysis of CCR2 expression in macrophages isolated from WT and CD36–/– hearts (n = 3/group). All data are means ± SE with n representing the number of mice per group. Statistical significance is determined by One-way ANOVA. *p < 0.05. |
PMC9428462_F6_389652.jpg | What is the principal component of this image? | 68Ga-DOTA-ECL1i PET/CT imaging the infiltration of CCR2 + monocyte/macrophages in hearts. (A,B) Representative 68Ga-DOTA-ECL1i PET/CT images and quantitative analysis showed higher tracer accumulation in the heart of CD36–/– (n = 5) compared with WT mice (n = 5) and CCR2–/– mice (n = 4/group). (C) Flow cytometric analysis of CCR2 expression in macrophages isolated from WT and CD36–/– hearts (n = 3/group). All data are means ± SE with n representing the number of mice per group. Statistical significance is determined by One-way ANOVA. *p < 0.05. |
PMC9428462_F7_389649.jpg | What is the focal point of this photograph? | Myocardial CD36 deletion associates with cardiac inflammation and impaired FA metabolisms. (A,B) Representative 68Ga-DOTA-ECL1i PET/CT images and quantitative analysis showed higher tracer accumulation in the heart of MHC-CD36–/– (n = 4/group) compared with those isolated from control mice (n = 5/group). Data are means ± SE with n representing the number of mice per group, *p < 0.05. (C) Gene expression of MHC-CD36–/– and control hearts obtained by RNA-seq. Up- and downregulated biological pathways from Reactome analysis using differentially regulated genes (MHC-CD36–/– vs. WT, > 1.6 or < 0.7-fold change). All data are (n = 3/group) with n representing the number of mice per group. Number of genes on the differentially regulated list is indicated on significance bar for each pathway. |
PMC9428462_F7_389647.jpg | What's the most prominent thing you notice in this picture? | Myocardial CD36 deletion associates with cardiac inflammation and impaired FA metabolisms. (A,B) Representative 68Ga-DOTA-ECL1i PET/CT images and quantitative analysis showed higher tracer accumulation in the heart of MHC-CD36–/– (n = 4/group) compared with those isolated from control mice (n = 5/group). Data are means ± SE with n representing the number of mice per group, *p < 0.05. (C) Gene expression of MHC-CD36–/– and control hearts obtained by RNA-seq. Up- and downregulated biological pathways from Reactome analysis using differentially regulated genes (MHC-CD36–/– vs. WT, > 1.6 or < 0.7-fold change). All data are (n = 3/group) with n representing the number of mice per group. Number of genes on the differentially regulated list is indicated on significance bar for each pathway. |
PMC9428470_F3_389656.jpg | What is the core subject represented in this visual? | Typical examples of TRI using the GGEC I in different situation (Case 1–6). Case 1: an example of percutaneous coronary intervention (PCI) using the Guidezilla™ guide extension catheter I (GGEC I) in left ascending artery chronic total occlusion (LAD CTO) using the antegrade wire approach. A 6F BL3.5 guiding catheter angiography showed the LAD 7-segment CTO (a). Miracle 6.0 was first selected under the support of a Finecross microcatheter, but failed due to insufficient support of the guiding catheter (b). GGEC I was sent along Miracle 6.0 to the LAD 6-segment and then the microcatheter was used to control Miracle 6.0 to smoothly penetrate the proximal fibrous cap of the occlusive disease (c). Miracle 6.0 was then carefully manipulated into the true lumen of the occluded distal blood vessel to the end of the LAD (d). Then, Miracle 6.0 was replaced with Sion via the Finecross microcatheter (e). Finally, the stent was successfully implanted after pre-expansion with balloons of different specifications (f). Case 2: An example of PCI using the GGEC I in right coronary artery (RCA) CTO with retrograde wire approach. TIG angiography showing the LAD 7-segment CTO (a) and RCA 1-segment CTO (b). First, the antegrade wire approach was used to open the LAD, and then the retrograde wire approach was used to open the RCA CTO (c, the white dotted line shows the retrograde pathway used in the operation). Under the support of the Corsair microcatheter, Sion was carefully manipulated through the S1 collateral branch (d) to advance the Corsair microcatheter to the RCA 3-segment along the guidewire, and changed to the UB 3 via the microcatheter; then, UB 3 was directed to the RCA 2-segment through the occluded vessel distal segment. Next, Miracle 6.0 was forwardly manipulated to penetrate the proximal fibrous cap of the occlusive lesion to the RCA 3-segment and the GGEC I was sent along Miracle 6.0 to the RCA1 segment. Then, the Reverse-Controlled Antegrade And Retrograde Subintimal Tracking (R-CART) technique was initiated (e), using Active Greeting Technique (AGT) to reversely manipulate Fielder XT into GGEC I (f). Fielder XT was pushed further forward into 6F SAL 1.0, then anchored with a balloon to push Corsair into 6F SAL 1.0 forcefully (g). The Rendezvous technique failed, and Sion was reverse manipulated into the forward Finecross microcatheter through the Corsair microcatheter, and the Finecross microcatheter was pushed forward to the posterior branches of left ventricular (PL) along Sion while withdrawing the Corsair microcatheter backward (h). Stents were implanted after dilating the occluded blood vessel with predilated balloons of different sizes along the guidewire after the Finecross microcatheter was removed (i). Case 3: An example of PCI using GGEC I in both LM and LAD bifurcation lesions. 6F JL3.5 angiography showed approximately 80% stenosis of the LM end, 50-80% stenosis of the LAD 6-7 segment, and subtotal occlusion in the proximal segment of D1 (a,b). The two Runthroughs were carefully manipulated to enter the ends of the LAD and D1, respectively, and narrow lesions were expanded with a balloon, resulting in residual stenosis of approximately 50% in the LM end, and severe dissection of LAD7 and proximal D1 with thrombolysis in myocardial infarction (TIMI) flow grade 3 as seen by angiography (c). The Crossover strategy was used to treat LM bifurcation lesions, and the inverse mini-crush technology was used to treat LAD and D1 bifurcation lesions (d). However, after repeated attempts, it was difficult for the stent to enter D1 and completely cover the lesion (e), so a stent was immediately implanted in LM-LAD (f). Angiography showed that the stent was fully expanded, with a blood flow of TIMI level 3 (g). Next, a GGEC I was sent along the guidewire to the opening of D1, and a stent successfully sent to D1 via the GGEC I and completely covered the lesion (h). After withdrawing the GGEC I to the LAD opening, the stent was successfully released in the D1 (i). Angiography showed that the stent was fully expanded and the blood flow was TIMI level 3 (j). Finally, by rewiring the Runthrough into the LAD and completing the Final Kissing step (k), the operation was a success (l). Case 4: An example of PCI using the GGEC I in LAD with extreme tortuosity and severely calcified lesions. 6F EBU 3.75 angiography showed extreme tortuosity and heavy calcification in LAD 6–8 segments with approximately 80% stenosis (a). Two Runthroughs were manipulated to reach the end of the LAD through the stenosis, and Sprinter 2.0 × 15 mm and NC Sprinter 2.5 × 15 mm were pushed into place in turn with difficulty, under the support of a double guidewire, which was used to expand the stenosis under high pressure (20–24 atm) (b). Then, three stents were implanted via the GGEC I from distal to proximal LAD 6–8 (c). Finally, NC-balloons of different figures were selected to expand the stents under high pressure (20–24 atm) (d), and angiography showed that the stents were fully expanded with a blood flow of TIMI 3 (e,f). Case 5: An example of PCI using the GGEC I in CTO of the RCA with abnormal opening. Angiography showed that the ascending aorta was significantly widened, the end of RCA 2 segment showed localized occlusion, and the bridging collaterals supplied blood to make the distal vessels partially visible (a). The LAD provided the collaterals, and the RCA was retrogradely perfused to the end of segment 3 (b). It was difficult to keep the 6F AL 1.0 guiding catheter in place, and Sion was patiently manipulated to “float” into the RCA (c). Then, the GGEC I was slowly pushed along Sion into the RCA (d). Sion was exchanged with Conquest pro 8–20 via the Finecross and manipulated carefully through the occluded segment (e) and into PL (f) under multi-position fluoroscopy. Under the support of the GGEC I, pre-expansion was performed using balloons of different specifications (g,h). Finally, the stent was successfully implanted in the occlusive segment (i). Case 6: An example of PCI using the GGEC I to release the burr incarceration. 6F EBU 3.75 angiography showed heavy calcification in LAD 6-8 segments with about 90% stenosis (a). Runthrough was carefully manipulated to reach the end of the LAD through the narrow lesions, and NC Trek 2.0 × 12 mm was selected for high-pressure dilatation (20–24 atm). However, the balloon was still not fully expanded, and the body had obvious indentation (b). Rotational atherectomy was started and a 1.5-mm burr was passed through the stenosis successfully, but it was incarcerated during the third polishing process (c). The first attempt to insert a second guidewire and dilate the stenosis near the burr with balloon was unsuccessful (d). The rotational catheter was immediately cut off, and the GGEC I was sent into the guiding catheter. It reached the LAD 6 segment along its inner core. After wrapping it tightly with the non-invasive head end of the GGEC I (dotted white line), the burr was successfully removed from the body together with the GGEC I (e). Finally, stents were successfully implanted after NC-balloon dilation (f). |
PMC9428488_F2_389660.jpg | What is the dominant medical problem in this image? | Characterization of STRO-1+/c-Kit+ hDPSCs. Representative confocal fluorescence images showing the expression of the stemness markers STRO-1 and c-Kit (A), the neural crest markers Nestin and SOX10 and the immunomodulatory molecule FasL (B) in immune-selected hDPSCs. Multilineage differentiation potential of STRO-1+/c-Kit+ hDPSCs is shown by the expression of osteogenic, myogenic and glial specific markers (C). Nuclei were counterstained with DAPI (blue). Scale bar: 10 μm. |
PMC9428488_F2_389663.jpg | What key item or scene is captured in this photo? | Characterization of STRO-1+/c-Kit+ hDPSCs. Representative confocal fluorescence images showing the expression of the stemness markers STRO-1 and c-Kit (A), the neural crest markers Nestin and SOX10 and the immunomodulatory molecule FasL (B) in immune-selected hDPSCs. Multilineage differentiation potential of STRO-1+/c-Kit+ hDPSCs is shown by the expression of osteogenic, myogenic and glial specific markers (C). Nuclei were counterstained with DAPI (blue). Scale bar: 10 μm. |
PMC9428488_F2_389657.jpg | What key item or scene is captured in this photo? | Characterization of STRO-1+/c-Kit+ hDPSCs. Representative confocal fluorescence images showing the expression of the stemness markers STRO-1 and c-Kit (A), the neural crest markers Nestin and SOX10 and the immunomodulatory molecule FasL (B) in immune-selected hDPSCs. Multilineage differentiation potential of STRO-1+/c-Kit+ hDPSCs is shown by the expression of osteogenic, myogenic and glial specific markers (C). Nuclei were counterstained with DAPI (blue). Scale bar: 10 μm. |
PMC9428488_F2_389661.jpg | Describe the main subject of this image. | Characterization of STRO-1+/c-Kit+ hDPSCs. Representative confocal fluorescence images showing the expression of the stemness markers STRO-1 and c-Kit (A), the neural crest markers Nestin and SOX10 and the immunomodulatory molecule FasL (B) in immune-selected hDPSCs. Multilineage differentiation potential of STRO-1+/c-Kit+ hDPSCs is shown by the expression of osteogenic, myogenic and glial specific markers (C). Nuclei were counterstained with DAPI (blue). Scale bar: 10 μm. |
PMC9428488_F2_389658.jpg | What's the most prominent thing you notice in this picture? | Characterization of STRO-1+/c-Kit+ hDPSCs. Representative confocal fluorescence images showing the expression of the stemness markers STRO-1 and c-Kit (A), the neural crest markers Nestin and SOX10 and the immunomodulatory molecule FasL (B) in immune-selected hDPSCs. Multilineage differentiation potential of STRO-1+/c-Kit+ hDPSCs is shown by the expression of osteogenic, myogenic and glial specific markers (C). Nuclei were counterstained with DAPI (blue). Scale bar: 10 μm. |
PMC9428488_F2_389662.jpg | What is the main focus of this visual representation? | Characterization of STRO-1+/c-Kit+ hDPSCs. Representative confocal fluorescence images showing the expression of the stemness markers STRO-1 and c-Kit (A), the neural crest markers Nestin and SOX10 and the immunomodulatory molecule FasL (B) in immune-selected hDPSCs. Multilineage differentiation potential of STRO-1+/c-Kit+ hDPSCs is shown by the expression of osteogenic, myogenic and glial specific markers (C). Nuclei were counterstained with DAPI (blue). Scale bar: 10 μm. |
PMC9428488_F6_389665.jpg | What is being portrayed in this visual content? | AFM analysis of cell morphology at the micro- and nanoscale. Topography images acquired on hDPSCs cultured on ED-PEDOT (A) before and (B) after 7 days of differentiation. In panels b, v and b, vi, the profile lines corresponding to the lines in b, iii and b, iv, are reported. |
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