corpusid
int64 5
255M
| openaccessinfo
dict | abstract
stringlengths 1
10k
| updated
stringlengths 20
24
|
|---|---|---|---|
10,012,729 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1039/C2MT20139A",
"MAG": "2004398009",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Nickel is an important cofactor for several microbial enzymes. The ATP-dependent NikABCDE transporter is one of several types of uptake pathways known to be important for nickel acquisition in microbes. The Escherichia coli NikA periplasmic binding protein is structurally homologous to the di- and oligopeptide binding proteins, DppA and OppA. This structural similarity raises interesting questions regarding the evolutionary relationships between the recognition of nickel ions and short peptides. We find that in defined minimal growth medium NikABCDE transports nickel ions in the presence of exogenously added L-histidine (L-His), but not D-histidine. Both nickel uptake in cells and nickel binding to purified NikA showed an L-His concentration dependence consistent with recognition of a Ni-(L-His)₂ complex. This discovery reveals parallels to the transport of other metal complexes, notably iron, and suggests the structural diversity of nickel transporters may arise from the need to recognize extracellular nickel complexed with different organic ligands, whether they be exogenously or endogenously produced. Further, these results suggest that experiments examining the physiology and ecology of nickel-requiring microbes should account for the possibility that the growth medium may not support nickel uptake. | 2022-12-16T00:08:07.374Z |
22,022,653 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1068/p7583",
"MAG": "1514675735",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | A 78-year-old patient with a right hemispheric sensorimotor ischemic stroke suffered from problems in ownership of her left arm (somatoparaphrenia). After recovering from motor weakness, however, body ownership problems remained present. To assess whether disturbed feelings of ownership coincided with an enhanced or diminished susceptibility for gaining ownership over a foreign hand, we applied the ‘Rubber Hand Illusion’ (RHI) to the ipsi- and contralesional hand. The RHI was significantly stronger for the contralesional left arm than for the right arm. In addition, solely visual exposure to the left rubber hand was sufficient to elicit strong feelings of ownership over the rubber hand. These findings suggest that disturbances in the feeling of body ownership allow a foreign hand to be incorporated more easily. | 2022-12-17T15:29:19.319Z |
848,019 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/JEZ.1402250202",
"MAG": "2166723086",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | The effect of short-term denervation (0, 12, 24, and 72 hours) on the levels of cyclic 3'5'-guanosine monophosphate (cGMP) and cyclic 3'5'-adenosine monophosphate (cAMP) in adult newt (Notophthalmus viridescens) forelimbs at 15, 22, and 35 days of regeneration was investigated. Regenerate blastema and stump cyclic nucleotide levels were compared with those of the contralateral intact forelimb and hindlimb, with levels in the normally regenerating blastema, and with levels measured in the forelimbs of intact, nonoperated animals. Variations in cyclic nucleotide levels occurred according to regeneration stage and tissue type. Changes in level were noted immediately upon denervation and subsequently at other sample times in all regenerate and control series. Parallel fluctuations occurred in regenerate stump and contralateral intact forelimbs. Our results from nonamputated denervated and sham-denervated animals indicate that short-term, denervation-associated cyclic nucleotide fluctuations cannot be attributed solely to the loss of innervation. | 2022-09-12T07:42:49.169Z |
222,029,044 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5694/j.1326-5377.1944.tb48640.x",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | surgery has not been perfected, but workers are continually striving to improve its technical procedures. Among the problems whose solution is sought are those connected with the arrest of hremorrhage and the prevention of meningo-cerebraladhesions. The latest contribution to the solution of these problems comes from F. D. Ingrahamand O. T. Bailey, who, in the first issue of the Journal of Neurosurgery, mentionedelsewherein these columns, publish the twenty-seventhpaper in a series of studieson plasmaproteinsemanatingfrom the department of physical chemistryof the HarvardMedical School. They report the use of fibrin "foam" as a hremostaticagentand fibrin "films" as a dural substituteand for use in the prevention of meningo-cerebral adhesions. Both the foam and the film are materialsderived from the proteinsconnected with the clotting mechanism. They may be varied considerably by small alterations in the conditions of their preparation. The fibrin foam is a spongy substance,and the film is pliable, elastic and translucent. Discussingfibrin foams first of all, Ingrahamand Bailey point out that bleeding from medium-sizedvessels in the central nervoussystemand its coveringscan as a rule be satisfactorily controlled by the conventional methods of hremostasis,such as the use of silver clips and electrocoagulation. Trouble arises with vessels on the surface of the dura and in the substanceof the brain and spinal cord. Ingrahamand Bailey enumerateand discussshortly the methodsthat have been used to control bleeding from thesevessels. Pressurefrom cotton padssoakedin saline solution is often successful,but not always-oozingmay start again when pressureis removedand much time may be lost. The applicationof muscle,as practisedby Cushing, is effective; the musclebecomesabsorbed. It is not always immediatelyavailable in sufficient quantitiesand it causes an appreciabletissue reaction. Fibrin tampons, as preparedby Gray and Harvey from animal and human fibrin, were effective and causedless reaction than muscle, but have never been widely used. Putnam made an advance when he used a soluble cellulose soaked in thrombin solution, the thrombin being either of human or of animal origin. The soluble cellulose was preparedby the oxidation of cellulose by nitrogen dioxide. Putnam's results were satisfactoryand Frantz found that the cellulose was rapidly absorbed and produced minimal tissue reaction. Bering has preparedan absorbablehremostaticagent from materials entirely of human origin, and it is this which Ingraham and Bailey have used. The fibrin foams are preparedfrom humanfibrinogen and humanthrombin. In the dry state they are composedof densestrandsof fibrin fibres with air spacesthat are easily visible. The foam is dull, porous and slightly brittle. The foams are supplied in the dry stateand with them is a small vial containing dried human thrombin. Before an operation at which foams are likely to be required the thrombin is dissolved in physiological saline solution. Portions of the foam are then placedin the thrombin solution. As the foam becomes saturateda moderate amount of shrinkage occurs; the thrombin solution penetratesto all parts of the mass. Ingraham and Bailey record the results of experiments on monkeys. Incidentally they comparedthe tissue reactions of soluble cellulose soaked in thrombin with those following the use of fibrin foams soakedin thrombin and found the latter more satisfactory. In clinical studieson human subjects they first of all used thrombin solution alone and applied it with cotton wool. This was not satisfactory. They then used the fibrin foam preparedin the manner just stated. With every type of hremorrhage they had striking and complete success. The number of surgical operations in which the method was used was 95; and in 18 instances material for examination was subsequently obtained at reoperation or at autopsy. Practically no detectable tissue reaction Occurred other than would be expected from the operative procedure itself. The fibrin foam was equally effective whether it was used alone or with bactericidalagentssuch as sulphadiazine and penicillin. The section of Ingraham and Bailey's paper on fibrin films is, if possible,more interestingthan the first section. The solution of the problem of finding a substitute for dura mater will also be concededas more difficult than the arrest of heemorrhage. In neurosurgeryof civilian life the problem will arise often enough with the removal of cerebral tumours, but in the injuries of war, dural substituteswill be more frequently required. The substancesthat have been used to replacedura mater include fascia lata, dural transplants,preserveddura, fat, periosteum, amniotic membrane, "Cargile membrane", metal foils of various kinds, "Cellophane" and rubber tissue. Thesesubstancesare enumeratedby Ingrahamand Batley, who quote the conclusion of Pudenz and Odom that although some of the materials showed promise, none could be consideredas having offered a solution to the problem. The fibrin films used by Ingraham and Bailey in their experimentaland clinical investigationsare prepared in sheetsof various sizes and thicknesses. They are composed of two parts-a protein part and a plasticizingagent. The protein part is at least 90% fibrin. When the films are preparedthe remainderis composedof glycerol. The immersion of the films in water or saline solution removesthe glycerol. The films aresmooth,translucent, uniform sheets with a considerable amount of elasticity. They can be sutured without being torn and can easily be trimmed to fit a dural defect. Ingraham and Bailey used the films first of all in monkeys and obtainedsatisfactoryresults. They then used them in the treatmentof 44 patients. At first the films were used in relatively hopelesssituationsor in procedureswhich were likely to be followed by a second operation. In general they were used when dura had to be removed or when cortex was left unprotectedbecauseof retraction of dura. Though the resultswere satisfactory,Ingrahamand Bailey are cautious in assessingthem. Patientsin whose cortex film has been in position for six months have shown no evidence of cortical irritation. The conclusion stated is that fibrin film is superior to other materials previously tested. | 2022-01-27T12:06:41.361Z |
224,000,942 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3760/CMA.J.ISSN.1672-7088.2009.09.005",
"MAG": "3031113903",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Objective To study the characteristics of peri-operative nursing of pelvic floor hernia, rectal prolapse combined with slow transit constipation. Methods 20 patients with pelvie floor hernia, internal rectal prolapse combined with slow-transit constipation were selected and given corresponding nursing according to peri-operative characteristics, and its influence on surgical effect of patients was ob-served. Results 18 cases restored to normal defecation, 2 cases still needed assisted defecation cathartic, but the amount decreased significantly. Conclusions Peri-operative nursing can promote the recovery of patients with pelvic floor hernia, rectal prolapse combined with colonic slow transit constipation.
Key words:
Pelvic floor hemia; Internal rectal prolapse; Slow transit constipation; Surgery; Nursing | 2022-01-27T11:56:12.167Z |
62,581,913 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1051/SNAMC/201405204",
"MAG": "2626593085",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | This paper deals with verification of three dimensional triangular prismatic discrete ordinates transport calculation code ENSEMBLE-TRIZ by comparison with multi-group Monte Carlo calculation code GMVP in a large fast breeder reactor. The reactor is a 750 MWe electric power sodium cooled reactor. Nuclear characteristics are calculated at beginning of cycle of an initial core and at beginning and end of cycle of equilibrium core. According to the calculations, the differences between the two methodologies are smaller than 0.0002 Δk in the multi-plication factor, relatively about 1% in the control rod reactivity, and 1% in the sodium void reactivity. | 2022-02-11T14:33:39.654Z |
229,460,314 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1088/1755-1315/602/1/012012",
"MAG": "3107344041",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.1088/1755-1315/602/1/012012"
} | This paper focuses on the general knowledge and basic use of timber based on the case study in United Kingdom. It is narrated from the whole life cycle of wood, from its cradle to death, including its growth, application, degradation, decay detection repairing methods and techniques, etc. The purpose of this paper is to provide guidance on the wider application of wood in architecture, especially on the conservation of historic buildings. | 2022-07-21T18:27:43.768Z |
18,978,493 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/CIMSA.2010.5611754",
"MAG": "2048140612",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | This paper is linked to a research proposing autonomous ships for risky humanitarian operations, like sea demining or poisonous spill recovery on the sea. This mission is based upon placing waypoints and the autonomous ships are under a Fuzzy control. Since ships have limited turning radii, a specific path planning strategy is developed, so the ship trajectory turns around waypoints at a suitable distance. The system is being tested with scaled ships. | 2022-07-30T20:37:00.223Z |
216,518,006 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.14744/ejmi.2020.92225",
"MAG": "3012667706",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | DOI: 10.14744/ejmi.2020.92225 EJMI 2020;4(2):181–186 | 2022-09-27T20:53:34.260Z |
108,657,188 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4103/JNRP.JNRP_381_18",
"MAG": "2925176124",
"PubMedCentral": "6454976"
},
"license": null,
"status": null,
"url": null
} | Aim: Carotid artery ligation carries a potential risk of ischemic complications even in patients with good collaterals and adequate cross-circulation. Preoperative assessment through balloon test occlusion (BTO) is technically challenging and not feasible in all patients. We analyze our experience with universal bypass without performing detailed cerebrovascular reserve (CVR) studies in 23 patients before carotid artery ligation. Patients and Methods: This was a retrospective analysis of the case records of 23 patients who underwent cervical carotid artery ligation for various indications since January 2009. Results: The study included 21 patients with cavernous carotid aneurysms, one patient with a large fusiform petrous carotid aneurysm, and one patient with recurrent glomus jugulare encasing the cervical internal carotid artery. The initial 12 patients underwent preoperative BTO with hypotensive challenge. All patients underwent a bypass procedure followed by carotid artery ligation irrespective of the BTO findings. Patients who successfully completed a BTO underwent a low-flow superficial temporal artery to middle cerebral artery bypass. A high-flow extracranial–intracranial bypass using a saphenous vein graft from external carotid artery to middle cerebral artery was done in all patients who either failed the BTO or did not undergo BTO. We had two operative mortalities and one poor outcome. All the other patients had a good recovery with a Glasgow outcome score of 5 at the last follow-up. Graft patency rates were 81.1% in both the low-flow and high-flow groups. Conclusion: Universal high-flow bypass is safe, effective, and should be preferred in all patients before carotid artery ligation. It obviates the need for detailed CVR assessment, especially in centers with limited resources. | 2022-10-07T00:58:33.727Z |
11,284,043 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1192/bjp.196.2.159",
"MAG": "2074855321",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://www.cambridge.org/core/services/aop-cambridge-core/content/view/DFC55912BA48AB3906FA75B9C2D982D0/S0007125000251684a.pdf/div-class-title-lithium-in-drinking-water-div.pdf"
} | In their short report, Ohgami et al [1][1] reported lithium levels in drinking water and linked them to the risk of suicide. Despite the report highlighting the pitfalls of drawing simple conclusions from large-scale ecological studies, a Google search shows that these findings have been widely | 2022-12-19T02:32:33.608Z |
24,712,108 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/AC050666H",
"MAG": "2078187264",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | In this study, the electron-transfer dissociation (ETD) behavior of cations derived from 27 different peptides (22 of which are tryptic peptides) has been studied in a 3D quadrupole ion trap mass spectrometer. Ion/ion reactions between peptide cations and nitrobenzene anions have been examined at both room temperature and in an elevated temperature bath gas environment to form ETD product ions. From the peptides studied, the ETD sequence coverage tends to be inversely related to peptide size. At room temperature, very high sequence coverage (approximately 100%) was observed for small peptides (< or =7 amino acids). For medium-sized peptides composed of 8-11 amino acids, the average sequence coverage was 46%. Larger peptides with 14 or more amino acids yielded an average sequence coverage of 23%. Elevated-temperature ETD provided increased sequence coverage over room-temperature experiments for the peptides of greater than 7 residues, giving an average of 67% for medium-sized peptides and 63% for larger peptides. Percent ETD, a measure of the extent of electron transfer, has also been calculated for the peptides and also shows an inverse relation with peptide size. Bath gas temperature does not have a consistent effect on percent ETD, however. For the tryptic peptides, fragmentation is localized at the ends of the peptides suggesting that the distribution of charge within the peptide may play an important role in determining fragmentation sites. A triply protonated peptide has also been studied and shows behavior similar to the doubly charged peptides. These preliminary results suggest that for a given charge state there is a maximum size for which high sequence coverage is obtained and that increasing the bath gas temperature can increase this maximum. | 2022-12-19T22:47:30.689Z |
142,921,251 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.15448/1984-7289.2012.3.13016",
"MAG": "1604485718",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://revistaseletronicas.pucrs.br/ojs/index.php/civitas/article/download/13016/8679"
} | The starting point for anthropology in cyberspace is the idea of “communication mediated by the computer”. Such an idea presupposes, explicitly or implicitly, a certain exteriority of the technical objects and, at the same time, it circumscribes agentive capacity exclusively to human beings. The present paper proposes a critical reflection about these assumptions by exploring a twofold theoretical and methodological inspiration. Firstly, it approaches the classical matrix about technique in “traditional societies”, as it was first conceived by M. Mauss, as a reference and it analyses the specificity attributed to the modern condition regarding technique. In a second and complementary moment , the paper advances as it systematizes the contemporary debates about agency and explores the limits of the human/technical dichotomy. Here it dwells specifically on the works of B. Latour, and the notion of cyborg. It is thus a rereading of the classical anthropological perspective regarding the approach of technique and the questioning of the modern notion of object-technical as it is applied to cyberspace. Finally, the paper discusses notions such as “usage”, “appropriation” and “representation” of technical objects in the anthropological studies in cyberspace. | 2022-12-23T02:06:05.860Z |
6,167,687 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/jxb/erm344",
"MAG": "2131089725",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://academic.oup.com/jxb/article-pdf/59/3/533/1546750/erm344.pdf"
} | Plant annexins are ubiquitous, soluble proteins capable of Ca(2+)-dependent and Ca(2+)-independent binding to endomembranes and the plasma membrane. Some members of this multigene family are capable of binding to F-actin, hydrolysing ATP and GTP, acting as peroxidases or cation channels. These multifunctional proteins are distributed throughout the plant and throughout the life cycle. Their expression and intracellular localization are under developmental and environmental control. The in vitro properties of annexins and their known, dynamic distribution patterns suggest that they could be central regulators or effectors of plant growth and stress signalling. Potentially, they could operate in signalling pathways involving cytosolic free calcium and reactive oxygen species. | 2022-12-27T21:10:04.746Z |
21,598,317 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICSTM.2015.7225416",
"MAG": "1568305199",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | The unbelievable growth and amount of information spread of social media helps the discovering of the new age result oriented recommender systems. Unfortunately the orthodoxies in the current system and the previous generation systems are structure oriented. For example rely mostly on the relativity of the network and the social demography. The investigative points discussed in this paper are generally based on the relative side of the communal factors. So the exploration leads naturally to the collaboration of the real time single directional social media dataset like twitter and the natural calamity events like cyclone, typhoons, earthquakes, Tsunami etc. The need for an interactive message application is higher than any other time because most of the countries are located at the geographically vulnerable point for earthquake invoked tsunami. So to probe such unfortunate event, there we require a vector backed machine of tweets which is based on the keyword, total no of words, etc. The location is estimated based on spatio-temporal pattern of events filtering. It will identify every user as a sensor and calculates. Whenever an earthquake occurs the report will be generated and forwarded to the user and the team of rescuers at the same time. So we can consider this as the fastest way when compared to the traditional JMA broadcast. | 2022-01-27T16:00:10.920Z |
308,577 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ANTEM.2016.7550161",
"MAG": "2513994420",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | A large array of dielectric resonator antenna is designed based on using Electrically Steerable Passive Array Radiator (ESPAR) concept as a subarray in the X-band. The concept is like using more than one excited element in the array to strengthen the far away elements when the mutual coupling becomes weak and affects the required power distribution for the array. | 2022-02-13T15:45:45.267Z |
75,269,385 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/ANNRHEUMDIS-2012-EULAR.1098",
"MAG": "2321278593",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Background Adhesive Capsulitis of the hip or “frozen hip” is not a diagnosis well documented in rheumatological textbooks or literature. There are only a few isolated case reports of adhesive capsulitis affecting joints other than the shoulder, predominantly published in orthopaedic literature.1-3 Objectives To increase awareness of what is probably an under diagnosed condition within the rheumatology discipline and the population with diabetes. Methods A 42-year-old woman with an 18 year history of poorly controlled type 1 diabetes mellitus was seen in the rheumatology clinic with a 9 month history of bilateral hip pain and restriction of movement. Her HbA1c had been consistently greater than 119 mmol/mol(13%) for more than 6 years prior to presentation. She had already received 3 steroid injections for presumed trochanteric bursitis. Initial X-rays and MRI scan of her hips showed no abnormality. On presentation she was unable to weight bear on the left hip. On examination her left hip was extremely irritable, with severe capsular restriction of movement. Spinal movement was normal with no nerve root signs. Results Blood tests showed an HbA1c of 143 mmol/mol(15.2%), ESR 36mm/hr, CRP 5mg/L, normal thyroid function, creatine kinase, biochemical and haematological parameters. She was negative for HLA-B27, rheumatoid factor and antinuclear antibodies. Repeat MRI scan of the left hip, lumbar spine and sacroiliac joints looking for underlying psoas muscle pathology or referred spinal pain showed only mild degenerative changes at the L4/5 disc, considered irrelevant. Initial diagnostic fluroscopic guided injection into the left hip with 10mls of 0.5% bupivacaine followed by a further fluoroscopic guided injection 1 month later with 120mg of depomedrone mixed with 10mls of 0.5% bupivacaine resulted in a transient improvement in pain, but not mobility, for 3 weeks. Her symptoms recurred within a few weeks. She continued her treatment with physiotherapy, anti-inflammatory and analgesic medication. After 18 months she developed a similar pattern of symptoms affecting the right hip. Repeat MRI of the both hips showed only some non-specific oedema in the right tensor fascia lata. She was subsequently diagnosed with bilateral frozen hips. Due to failure of treatment she was referred to the orthopaedic department for manipulation and arthroscopic pressure dilatation under GA. Conclusions Adhesive capsulitis is a relatively common condition affecting the shoulder.4 It is rare and poorly recognised in the hip. There is a common association between adhesive capsulitis of the shoulder and diabetes, with a prevalence of 10.3% in type 1 and 22.4% in type 2 diabetes.5 Frozen hip shares similar clinical characteristics and associations with the shoulder presentation and it may respond to similar therapeutic interventions. However, as with the shoulder, treatment can be unrewarding. There is a paucity of literature on frozen hip. This case alerts rheumatologists to the possible diagnosis in what is a rare, but nevertheless, a probably poorly recognised condition. References MD Chard, JR Jenner. BMJ 1988;297:596-597 M Lequesne et al. Skeletal Radiol.1981;6(1):1-10 J Byrd,K Jones. Arthroscopy.2006 Jan;22(1):89-94 D Lebiedz-Odrobina,J Kay. Rheum Dis Clin North Am.2010 Nov;36(4):681-99 PE Arkkila et al. Ann Rheum Dis.1996 Dec;55(12):907-14 Disclosure of Interest None Declared | 2022-02-11T07:32:08.564Z |
15,440,985 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICIN.2011.6081101",
"MAG": "2041313022",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | The progress of Internet of Things is hampered by a fragmented world of standards and players in the field. The different and many proprietary platforms can easily lock an end user to a solution that may be outdated quickly. It may also be very expensive to add new functionality to these systems. Along with it is the lack of a solution where developers, operators and end users can interact with each other in a fruitful cooperation. In this paper we present ISIS (Infrastructure for Integrated Services), an integrated framework that aims to create a complete software tool chain, to tackle the integration issues for IoT in general, and smart house solutions in particular. We demonstrate how such a service-driven development process based on models and code generation for heterogeneous platforms can simplify development of services in IoT. | 2022-07-16T22:59:34.770Z |
28,707,578 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1001/ARCHPEDI.1979.02130060092026",
"MAG": "2161375257",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Prune belly syndrome is a clinical triad of hypoplasia of the abdominal muscles, urinary tract abnormalities, and cryptorchidism. The first feature gives the abdomens of affected infants a characteristic wrinkled appearance, hence the name of the syndrome. Urinary tract findings include hypoplastic or dysplastic kidneys, hydronephrosis, hydroureter, megacystis, and urethral obstruction. Many other abnormalities have been described, including malrotation of the gut, small bowel atresia, imperforate anus, cardiovascular malformations, pulmonary hypoplasia, and various skeletal anomalies. 1 To our knowledge, the patient described herein is the first reported case of prune belly syndrome associated with Hirschsprung's disease. Report of a Case .—The patient was a term infant delivered to a 16-year-old prima gravida mother via cesarean section because of cephalopelvic disproportion. The pregnancy and delivery were free of any other complications. At birth, the infant was noted to have a prominent forehead, large ears, hypoplastic abdominal muscles, a small penis, an | 2022-09-08T00:44:30.005Z |
117,913,584 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2514/8.8962",
"MAG": "1546259917",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Summary Some results from the theory of integral equations, applicable to the problem of free lateral vibration of beams, are presented and the Cauchy function method is utilized in the solution, by successive approximations, for the lowest frequency and modal configuration of a stepped beam. The results are then com pared to the exact solution based on the differential equation of motion. | 2022-09-14T01:42:29.199Z |
117,577,603 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.13182/FST91-A29361",
"MAG": "1505523738",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | This paper studies confinement properties of 1 = 2 torsatron/heliotron configurations with number of toroidal field periods, M, in the range of 10 to 14. This involves the calculation of zero-current and flux-conserving equilibria; stability against Mercier modes and low-n ideal modes, with n denoting the toroidal mode number; and orbit confinement of deeply trapped energetic particles. Optimization of both magnetohydrodynamic (MHD) and transport properties is pursued under the condition of plasma aspect ratio A = R/a {ge} 7, with R denoting the major radius and a the average plasma radius. For configurations with M, {le} 12, an average MHD beta limit of 4 to 5% is possible. The addition of a quadrupole field improves the confinement of trapped particles at zero pressure, but particle losses increase with increasing beta. This loss is less severe if the vacuum magnetic axis is shifted slightly inward. A configuration with M = 10, a coil pitch parameter p{sub c} in the range 1.25 to 1.30, and an added quadrupole field satisfies the beta and energetic particle confinement requirements for the next generation of large torsatron/heliotron devices. | 2022-09-15T03:21:10.588Z |
142,569,748 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1744-6570.1969.TB00346.X",
"MAG": "1527364135",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Summary
AN effort was made to find personal qualifications that might be predictive of earnings in business. A follow-up by questionnaire five years after graduation was made for members of three MBA classes who had previously taken an eleven-instrument battery. Ninety percent responded.
A comparison of the highest third and the lowest in terms of present compensation showed 13 differences at the .05 level of significance or higher among 55 predictor variables. At the .01 level were second year Graduate School of Business grade point average (GPA), Strong Vocational Interest Blank (SVIB) Personnel and Management Orientation scales, Guilford-Zimmerman Ascendance, Ghiselli's Decision Making and Initiative (from his Self-Description Inventory), and the Individual Background Survey. Hours of work and job satisfaction were greater for high earners. | 2022-10-18T18:48:56.954Z |
19,101,653 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/bioengineering4020034",
"MAG": "2606473534",
"PubMedCentral": "5590460"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2306-5354/4/2/34/pdf?version=1492497553"
} | There is intense interest in how bacteria interact with mucin glycoproteins in order to colonise mucosal surfaces. In this study, we have assessed the feasibility of using recombinant mucin glycoproteins to study the interaction of the gastric pathogen Helicobacter pylori with MUC5AC, a mucin which the organism exhibits a distinct tropism for. Stable clonal populations of cells expressing a construct encoding for a truncated version of MUC5AC containing N- and C-termini interspersed with two native tandem repeat sequences (N + 2TR + C) were generated. Binding of H. pylori to protein immunoprecipitated from cell lysates and supernatants was assessed. High molecular weight mucin could be detected in both cell lysates and supernatants of transfected cells. Recombinant protein formed high molecular weight oligomers, was both N and O glycosylated, underwent cleavage similar to native MUC5AC and was secreted from the cell. H. pylori bound better to secreted mucin than intracellular mucin suggesting that modifications on extracellular MUC5AC promoted binding. Lectin analysis demonstrated that secreted mucin was differentially glycosylated compared to intracellular mucin. H. pylori also bound to a recombinant C-terminus MUC5AC protein, but binding to this protein did not inhibit binding to the N + 2TR + C protein. This study demonstrates the feasibility of using recombinant mucins containing tandem repeat sequences to assess microbial mucin interactions. | 2022-12-02T12:00:18.470Z |
24,061,395 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/DC.2840110207",
"MAG": "2077523477",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | The cytologic findings from 50 cases of asymptomatic Hashimoto's thyroiditis diagnosed by fine‐needle aspiration are reviewed. All patients were referred for fine‐needle aspiration by the same physician: 48 because of thyroid enlargement and the clinical suspicion of Hashimoto's thyroiditis, two because of a small thyroid nodule. Positive antimicrosomal (antithyroid peroxidase) and/or antithyroglobulin antibody tilers (performed by the same laboratory using the same technique) were present in only 25 of 48 patients evaluated. Cytologic findings included a predominantly lymphocytic process in 92% of the cases and a predominantly oxyphilic (Askanazy/Hürthle) cell process in 8% of the cases. It is likely that all patients were in an early stage of the autoimmune process. Our data indicate that the incidence of Hashimoto's thyroiditis is considerably higher than when recognized only by serologic tests for antibodies. Diagn Cytopathol 1994; 11:141–145. © 1994 Wiley‐Liss, Inc. | 2022-12-10T18:18:39.810Z |
25,587,778 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2310/6650.2001.33628",
"MAG": "2011569172",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Abstract Background Recently, we reported an unexpected ubiquitous expression of calcitonin (CT)-mRNA in a hamster peritonitis model of sepsis. Using this animal model, we undertook a study to further investigate the pattern of expression of the calcitonin I (CALC-I) gene and CT gene-related peptide (CGRP)-mRNA in sepsis. Methods Live Escherichia coli impregnated in agar pellets were implanted in the peritoneal cavities of hamsters. Twelve hours after sepsis induction, the septic and healthy control animals were sacrificed and tissues and peritoneal macrophages were collected. CGRP-mRNA content was evaluated by reverse transcription polymerase chain reaction (RT-PCR), quantitated by the Taq-Man technique, and compared with the mRNA expression of CT, tumor necrosis factor α (TNF-α), and interleukin-6 (IL-6). The 5′ untranslated regions of the mRNA and potential alternative splicing sites were identified by 5′ rapid amplification of cDNA ends. Results We found a tissue-wide, ubiquitous and uniform expression of CGRP-mRNA in all septic tissues examined. CGRP-mRNA was detectable by RT-PCR in various extraneuronal and extrathyroidal septic tissues, but not in healthy control tissues. As found for CT-mRNA in our earlier studies, CGRP-mRNA seemed to be more specifically up-regulated as compared with other classical cytokines (ie, IL-6 and TNF-α). Importantly, the 5′ untranslated sequence in control and septic thyroid was similar to the sequence obtained from septic spleen. Conclusions We postulate the presence of microbial infection-specific response elements in the CALC-I gene promotor, which, upon a specific stimulus, override the tissue-selective expression pattern. This new form of endocrine plasticity may be of importance in the response to systemic inflammation. | 2022-12-12T04:19:14.615Z |
71,888,083 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.12968/NREC.2011.13.12.587",
"MAG": "2039017734",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Outcome 2: before people are given any examination, care, treatment or support, they should be asked if they agree to it | 2022-02-11T10:21:22.195Z |
3,184,041 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7598/cst2014.732",
"MAG": "2185817700",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "http://www.e-journals.in/pdf/V3N2/750-758.pdf"
} | The detection and quantification of potential genotoxic impurities (PGIs) play an important role in the pharmaceutical industry. The industry needs highly selective and sensitive analytical methods for trace level quantification of these PGIs in drug substances. A sensitive and stability indicating LC-MS/MS method was developed for the simultaneous detection and quantification of (S)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one (ABO) and (S)-4-(4-nitrobenzyl)- 1,3-oxazolidin-2-one (NBO) PGIs in zolmitriptan. Method utilizes, Hypersil BDS C18 column (50 mm x 4.6 mm, 3.0 μm) with electrospray ionization in selective ion recording (SIR) mode for quantitation of ABO and NBO PGIs. The method validated as per International Conference on Harmonization (ICH) guidelines and is able to quantitate ABO at 0.1 ppm and NBO at 0.2 ppm with respect to 2.0 mg/mL of zolmitriptan. The method was linear in the range of 0.1-2.0 ppm for ABO and 0.2-2.0 ppm for NBO which matches the range of LOQ-200% of specification level (1.0 ppm). The correlation coefficient obtained was >0.999 in both the cases. The impurities were not present in the three studied pure and formulation batches of zolmitriptan. The accuracy of the method was ranged between 98.6-102.5% for both ABO and NBO PGIs. The developed method is a good quality control tool to monitor ABO and NBO PGIs in zolmitriptan during its manufacture. | 2022-02-13T12:55:23.566Z |
121,807,769 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.308351",
"MAG": "2054083670",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | A theoretical model to describe localization of high-power electromagnetic field and abrupt local increasing of its amplitude in transparent nonabsorbing dielectric is presented. It is based on formation of unstable field structure in dielectric microstructures. Possibility for field instability to arise is estimated making use of model of diffraction of high-amplitude plane wave on sphere and cylinder which radii are about radiation wavelength. Field instability is shown to be threshold-like phenomenon. There are estimated threshold amplitude of incident wave and field amplification in the microsphere and cylinder. Possible laser-induced processes in transparent dielectric are discussed. | 2022-02-09T19:47:13.456Z |
129,613,153 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/esp.3678",
"MAG": "1583258757",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | To celebrate World Soil Day 2014, this editorial summary and Special Issue draws together a number of the most significant contributions that have appeared in Earth Surface Processes and Landforms since 2010. As a group they show the increasing importance of interdisciplinary work in this area of overlap, and point to significant opportunities for future research development, particularly with respect to integrated modelling and interactions with climate change. Copyright © 2014 John Wiley & Sons, Ltd. | 2022-07-31T08:20:04.819Z |
234,315,809 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4013/RECHTD.2020.123.04",
"MAG": "3121019878",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | The paper examines the complex, multidisciplinary and multidimensional scope of the coronavirus pandemic, focusing on its intertwined implications for international, supranational and domestic laws. The global reach of the phenomenon has highlighted limits and structural gaps at all levels of government in human society, raising questions to which rulers will have to give precise answers. | 2022-08-26T23:17:36.177Z |
136,591,485 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2320/MATERTRANS.M2012363",
"MAG": "2019755477",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | A conductive nanoink was prepared using copper nanoparticles (CNPs). In order to prevent the oxidation of CNPs, the particles were coated by 1-octanethiol using Vaporized Self-Assembled Multi-layers (VSAMs) method. The coating of 1-octanethiol onto CNPs was confirmed by transmission electron microscope (TEM) and X-ray photoelectron spectroscopy (XPS). Dispersion stability of CNPs was checked by monitoring its viscosity over 6 weeks. The sheet-type of patterned samples using the fabricated ink was sintered at 350 and 230°C, respectively. Electrical resistivity was measured to be 5.69 © 10183·m when sintered at 350°C and 7.67 © 10183·m when sintered at 230°C. These results were 3.4 and 4.6 times than the value for bulk copper. During the sintering process, the optimum temperature of removing organic materials was found to be 200°C. This removal temperature dramatically influenced necking and the density of samples. Therefore, 1-octanethiol VSAMs and 1-octanol ink were used successfully for the low-temperature sintering process to fabricate conductive Cu patterns by finding the optimum temperature of 200°C for complete removal of organic materials prior to the sintering process. [doi:10.2320/matertrans.M2012363] | 2022-09-08T16:16:06.583Z |
154,550,546 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3905/jai.2003.319089",
"MAG": "2064069416",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | In this article the authors examine persistence of hedge fund performance and find that returns are not persistent while risk (volatility in returns) and correlations to underlying markets are highly persistent. Less risky funds tend to be less correlated with underlying markets and more efficient at bearing risk than their more risky counterparts. They analyze various determinants of hedge fund performance and develop a multifactor model to identify funds whose superior performance is based on underlying investment skill, rather than on risk-taking or undue exposure to markets. For the period 1996 to 2001, portfolios of such funds generate significantly higher risk-adjusted returns (Sharpe ratio of 4.14) than portfolios containing all funds (1.38), portfolios constructed solely on the basis of past returns (0.75), and portfolios constructed based on past Sharpe ratios (2.42). | 2022-09-09T03:18:02.442Z |
12,234,220 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00222895.2011.584085",
"MAG": "2046992111",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | ABSTRACT The supplementary motor area (SMA) is involved in planning limb movements. An important component of such planning is the prediction of the sensory consequences of action. The authors used transcranial magnetic stimulation (TMS) to probe the contribution of SMA to motor planning during a predictive load-bearing task. Single TMS pulses were delivered over the SMA after a cue instructing the participant to release a platform supporting his or her right hand, which in turn held a 2 kg mass. Participants were less able to bear the load successfully when TMS was delivered 400–500 ms prior to the response. This result suggests that the SMA contributes to the prediction of the sensory consequences of movement well before movement onset. | 2022-12-12T17:21:18.683Z |
247,651,859 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3991/ijim.v16i06.28905",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://online-journals.org/index.php/i-jim/article/download/28905/11019"
} |
Though expanding computational thinking to primary school students has become more prevalent, there is a lack of appropriate didactics. Educational robotics offers a possible approach. However, innovations can only find their way into the classroom if teachers find them feasible and meaningful. Thus, appropriate training and further education of teachers are becoming a necessity. This paper reports on investigating professional development for teachers in programming robots by integrating the method of storytelling in their teaching. It draws on the Technology Usage Inventory (TUI) model to explore how an interdisciplinary intervention with programmable robots, combined with the storytelling method “Tell, Draw & Code” can influence the intention to use them in the classroom. Comparing the pre-and post-test and the qualitative data analysis shows a significant increase in positive attitudes towards the use of robots. The learning scenarios produced by the participants show how successful implementation can succeed. These findings highlight the need for teachers to explore, reflect, and experience the potential of new technologies as part of their teacher development to implement innovations sustainably. The quasi-experimental study shows that this problem-based and interdisciplinary didactic setting is particularly well received by teachers because it promotes computational thinking, narrative, and reading skills in primary school students in equal measure, and it can be easily taught and transferred.
| 2022-12-17T11:56:46.351Z |
125,958,725 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1117/12.2251025",
"MAG": "2592075850",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Fluorescent lifetime imaging is an optical technique that facilitates imaging molecular interactions and cellular functions. Because the excited lifetime of a fluorophore is sensitive to its local microenvironment,1, 2 measurement of fluorescent lifetimes can be used to accurately detect regional changes in temperature, pH, and ion concentration. However, typical state of the art fluorescent lifetime methods are severely limited when it comes to acquisition time (on the order of seconds to minutes) and video rate imaging. Here we show that compressed ultrafast photography (CUP) can be used in conjunction with fluorescent lifetime imaging to overcome these acquisition rate limitations. Frame rates up to one hundred billion frames per second have been demonstrated with compressed ultrafast photography using a streak camera.3 These rates are achieved by encoding time in the spatial direction with a pseudo-random binary pattern. The time domain information is then reconstructed using a compressed sensing algorithm, resulting in a cube of data (x,y,t) for each readout image. Thus, application of compressed ultrafast photography will allow us to acquire an entire fluorescent lifetime image with a single laser pulse. Using a streak camera with a high-speed CMOS camera, acquisition rates of 100 frames per second can be achieved, which will significantly enhance our ability to quantitatively measure complex biological events with high spatial and temporal resolution. In particular, we will demonstrate the ability of this technique to do single-shot fluorescent lifetime imaging of cells and microspheres. | 2022-10-19T07:45:26.624Z |
21,147,771 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1212/01.WNL.0000106945.68292.DC",
"MAG": "2024081584",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Sleep-related hyperkinetic seizures are a common feature of nocturnal frontal lobe epilepsy. Although sleep-related seizures with a temporal lobe origin have been reported, they commonly lack hyperkinetic activity. The authors describe three patients with sleep-related seizures characterized by frenetic, agitated, hyperactive movements (bimanual/bipedal activity, rocking, axial, pelvic, and hemiballistic movements), in whom stereo-EEG investigation and surgical outcome demonstrated a temporal lobe origin of the attacks. | 2022-12-20T15:45:26.311Z |
226,919,654 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2139/ssrn.3138041",
"MAG": "3032040228",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | The main task of marketing is to study the characteristics of consumers and their behavior. It is necessary to answer questions about the behavior of the consumer before, during and after the purchase. Consumer behavior research aims to reveal - how a purchase decision is taken, who takes it, as a result of what factors it is formed and what the customer's reaction is. Goods are of differnt value and importance to consumers, as a result the decision-making process is not the same. For example, there is a difference in the purchasing decision process if the item of purchase is a piece of furniture or if it is a laundry powder.The better an organization focuses on how consumers respond to the different characteristics of the product, the change in price and the advertising impact, the greater will be its advantage over competitors. "This article discusses and researches consumer behavior. The factors influencing consumer behavior are discussed in detail. A special place in this analysis is dedicated to the stages of the purchasing decision process. There are five stages in the decision-making process: finding the problem; search for information; assessing alternatives; purchase decision; post-purchase behavior.For the most part, consumer behavior has been learned. Users learn from their previous experience. Loyalty to a particular brand is related to the learning process. Many aspects of the behaviors of buyer organizations are different from consumer behavior. Some key differences are: the characteristics of the search, the number of potential buyers, the purpose of the purchase, the purchase criteria, the size of the order, the interaction between the seller and the buyer, as well as the influence of the other business organizations. The decision-making stages of the purchase by the organization are the same as those of users when making a purchase decision. | 2022-08-29T03:35:52.329Z |
253,067,232 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.55708/js0110004",
"MAG": null,
"PubMedCentral": null
},
"license": "CCBYSA",
"status": "HYBRID",
"url": "https://www.jenrs.com/?smd_process_download=1&download_id=3069"
} | : Soil fertility needs to be assessed to develop strategies for long-term agricultural productivity. A study has been undertaken at Shirol tehsil, Kolhapur district, Maharashtra state, India to evaluate the fertility status of soil using nutrient index approach. For the present study PH, organic carbon, and EC were chosen as potential markers of soil quality along with primary nutrient potash and phosphrous. Objectives of this research are i)To provide nutrient availability index, ii) To assess soil fertility status and sugarcane productivity in the study area. Based on the soil parameters analysis, it is found that the soil is fertile. Sugarcane is the most cultivated crop in this area and the productivity of sugarcane is observed to be higher in study area as compared to national productivity. The nutrient index values for PH, Organic carbon and Phosphorous were normal, EC was low, and Potash was high. It is also observed that all ten years of study potash is high. Productivity change as well as nutrient values change over a period of time tested with standard t- test approach. | 2022-11-09T15:59:00.592Z |
28,649,608 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TAP.2015.2438340",
"MAG": "1516060123",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | A novel metallic multiband frequency selective surface (FSS) is presented. The proposed FSS structure has operation bands from closely spaced to far from each other (wide range of band ratio) and has high selectivity at each operation band. The unit cell comprises four small square slots, each loaded with multiple stub resonators. The stubs are placed in each slot in such a way that the unit cell response to both TE and TM polarizations are the same. To miniaturize the unit cell and cover the lower frequency range, each stub resonator is terminated with a U-shaped section. The length of each stubs within the slot determine the resonant frequency of each passbands. The band ratio can be set from 1.09 (close to each other) up to 2.35 (far from each other). Single, dual, triple, and quad band FSS structures are designed and simulated through HFSS software package. The fabricated dual-band unit cell shows that the proposed FSS structure can provide two close to each other bands, 9.8 and 10.9 GHz. Also, the measured results of a fabricated dual-band 17 × 17 FSS array show a relatively stable response to variations of incidence angle and polarization state. | 2022-12-09T01:21:49.907Z |
232,180,672 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1086/662592",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | In the September 2011 issue of the journal, in the article by van Velzen et al (van Velzen EVH, Reilly JS, Kavanagh K, Leanord A, Edwards GFS, Girvan EK, Gould IM, MacKenzie FM, Masterton R. A retrospective cohort study into acquisition of MRSA and associated risk factors after implementation of universal screening in Scottish hospitals. Infect ControlHosp Epidemiol2011;32(9):889-896), the academic degree for the fifth author (Edwards) is incorrect. The correct degree is PhD (not MD). The authors regret this error. | 2022-01-27T12:01:45.214Z |
165,252,972 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.17162/rt.v28i2.788",
"MAG": "2761002094",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "HYBRID",
"url": "https://revistas.upeu.edu.pe/index.php/r_theologika/article/download/285/283"
} | “El Anticristo, los 1260 dias y el rapto secreto: Origen y desarrollo de la escuela futurista de interpretacion profetica y su impacto en la Iglesia Adventista del Septimo Dia” — El presente articulo estudia el proceso historico, teologico y metodologico que caracterizo el desarrollo del sistema futurista de interpretacion profetica, especialmente de los libros de Daniel y Apocalipsis, hasta su establecimiento como el Dispensacionalismo. En este sentido, se muestra que la adopcion de la metodologia hermeneutica del futurismo, basado en una interpretacion literal de la Escritura y el concepto de doble cumplimiento ha ido ganando terreno entre los movimiento protestantes hasta casi eliminar al sistema de interpretacion profetica de la reforma, conocido como historicismo. De este modo, se presenta que la aceptacion de los planteamientos metodologicos del sistema futurista, inexorablemente llevan a transformar la interpretacion escatologica, sea para el protestantismo como para el adventismo. | 2022-02-08T20:03:12.996Z |
73,000,333 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2217/BMT.13.32",
"MAG": "2140704013",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | 259 ISSN 1758-1923 10.2217/BMT.13.32 © 2013 Future Medicine Ltd Breast Cancer Manage. (2013) 2(4), 259–262 Breast cancer is a heterogeneous disease that can be divided into five biological subtypes based on gene-expression profiling: luminal A, luminal B, ErbB2, normallike and basal-like [1]. Of all the molecular subtypes, basal-like breast cancer (BLBC) is of particular clinical significance, as it associates with an aggressive clinical history, development of recurrence, distant metastasis and shorter survival, and usually occurs in younger women [2,3]. The terminology ‘basal-like’ stems from the similarity between the molecular profiling of tumors pertaining to this subgroup with that of undifferentiated breast stem cells, which reside with basal/myoepithelial cells (termed basal-like cells) of the normal breast [3]. In addition to BRCA1 germline mutations or a dysfunctional BRCA1 pathway [3], BLBC is commonly characterized by the lack of expression of estrogen receptor, progesterone receptor and HER2, and positive expression of basal markers (CK5/6 and CK14) [2,3]. The consequent absence of effective targeted therapies, such as endocrine and anti-HER2 therapies, and poor response to standard chemotherapy, which is common among patients, often results in a rapidly fatal clinical outcome for this disease. This type of breast cancer has a tendency towards early metastatic spread to the brain and lung, which are sites known to be associated with a poor prognosis and short survival [2,3]. Thus, novel treatment strategies based on the biology of BLBC are urgently needed to combat this life-threatening disease. Intriguingly, BLBC possesses many epithelial–mesenchymal transition (EMT) characteristics and exhibits robust cancer stem cell (CSC)-like features [4,5]. EMT is an essential phenotypic conversion during embryonic development, tissue remodeling, wound healing and metastasis [6,7]. In these EMT processes, epithelial cells acquire f ibroblast-like properties and exhibit reduced intercellular adhesion and increased motility; they can also break through the basal membrane and migrate over long distances, owing to profound changes in their cytoskeletal architecture. Activation of this normally latent EMT program confers a distinct advantage on cancer cells for invasion and metastasis to distant organs or tissues. In addition to enhancing the invasiveness and metastatic | 2022-06-25T23:03:12.552Z |
191,441,658 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00940771.1995.11496128",
"MAG": "1555896319",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | "Wait a minute folks. Before we get started today, we're going to change the seat ing arrangements." A chorus of complaints and general grousing greeted me as I made the announcement. "When I call your name, come sit in the desk I point to." I began calling out names; the students reluctantly came forward taking their new places. Things went smoothly until I called Kelly's name. As she took her seat behind one of the boys, he muttered "gross," scoot ing his desk forward as far a possible with out hitting the desk in front of him. Thinking it a typical boy's reaction, I said nothing then called the next name, Sheila. Sheila stared at me for a moment without moving. When I repeated her name, she gathered her books, dumped them into her bookbag, and stomped over to me. "Oh God," I groaned inwardly, "what now?" Sheila approached me then whis pered something inaudible. "What's wrong?" I asked. "I said I don't want to sit near Kelly." "Why not?" I asked impatiently while the class grew restless. "Because last year in the sixth grade Kelly had bugs in her hair. My mother told me not to sit next to her." | 2022-07-10T04:25:18.415Z |
186,213,582 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1098/rstl.1757.0109",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
} | It is in this rock, that the Ammonitæ, or Snake-stones, as they are commonly called, are found, which have undoubtedly been formed in exuviæ of fishes of that shape; and though none of that species are now to be met with in the seas thereabouts, yet they in many particulars resemble the Nautilus, which is well known. | 2022-09-05T20:46:56.680Z |
22,832,155 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1467-9663.1986.TB01300.X",
"MAG": "2133444320",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} |
The authors discuss selected findings of a study conducted between 1974 and 1980 in a rural area of Machakos district, Kenya. As part of a broader epidemiological study, data were collected concerning aspects of migration and circulation. These findings and methodological problems encountered in analyzing the data are discussed. Direct and indirect measures of migration are included. Figures are presented for annual intra-area, in- and out-migration rates; migration rates by age and sex; and the most common categories of persons involved in different types of circulation. Reasons for observed changes in migration patterns are discussed.
| 2022-12-23T08:10:41.154Z |
85,498,223 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3390/rs11030287",
"MAG": "2913286592",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.mdpi.com/2072-4292/11/3/287/pdf?version=1549014674"
} | The timely and efficient generation of detailed damage maps is of fundamental importance following disaster events to speed up first responders’ (FR) rescue activities and help trapped victims. Several works dealing with the automated detection of building damages have been published in the last decade. The increasingly widespread availability of inexpensive UAV platforms has also driven their recent adoption for rescue operations (i.e., search and rescue). Their deployment, however, remains largely limited to visual image inspection by skilled operators, limiting their applicability in time-constrained real conditions. This paper proposes a new solution to autonomously map building damages with a commercial UAV in near real-time. The solution integrates different components that allow the live streaming of the images on a laptop and their processing on the fly. Advanced photogrammetric techniques and deep learning algorithms are combined to deliver a true-orthophoto showing the position of building damages, which are already processed by the time the UAV returns to base. These algorithms have been customized to deliver fast results, fulfilling the near real-time requirements. The complete solution has been tested in different conditions, and received positive feedback by the FR involved in the EU funded project INACHUS. Two realistic pilot tests are described in the paper. The achieved results show the great potential of the presented approach, how close the proposed solution is to FR’ expectations, and where more work is still needed. | 2022-12-30T19:40:33.851Z |
35,609,243 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/J003v04n03_11",
"MAG": "2083731326",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Thumb loss is a significant disability for the hand. This paper describes a traumatic thumb injury and amputation after which the occupational therapist placed an orthotic device to substitute for the thumb. When the patient was undecided about a proposed toe-to-hand transplant, the occupational therapist fabricated a mold of the toe, and attached it to the patient's hand. After training with the mold, the patient was ready to accept the toe-to-hand transplant. The post transplant occupational therapy program and patient's return to work was described. | 2022-02-12T08:16:49.191Z |
79,445,591 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1158/1538-7445.AM2016-5169",
"MAG": "2492782016",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Ovarian cancer is the leading cause of death from gynecologic malignancy in the United States. Most cases of ovarian cancer present in late stages leading to recurrent disease which is incurable. Few effective targeted therapies are available to treat ovarian cancer other than non-specific, toxic chemotherapy. Ovarian cancer is often fatal due to innate or acquired chemoresistance. Lipid mediators are linked to many pathological processes including inflammation and cancer. The lipid prostaglandin E2 (PGE2) is synthesized by cyclooxygenases, COX-1 and COX-2, and elevated expression of COX and increased PGE2 levels are functionally linked to the progression of many cancers. PGE2 is exported from the cell where it acts in a paracrine and autocrine manner by activating a family of four G-protein coupled receptors (EP1-4) which are linked to different intracellular signaling pathways. EP1 is coupled to calcium mobilization and PKC; whereas, EP2 and EP4 activate PKA/cAMP, PI3K and ERK pathways. EP3 generally inhibits cAMP levels. COX-1 has been shown to be overexpressed in primary ovarian cancer as well as in many ovarian cancer cell lines. The EP4 receptor is overexpressed and plays a mechanistic role in various malignancies including breast and colon. Due to toxicity concerns surrounding global inhibition of the COX enzymes and, in an effort to identify new targeted therapies for the treatment of ovarian cancer, our objective was to determine the expression as well as the functional role of the PGE2 receptor EP4 in ovarian cancer. We hypothesized that the EP4 receptor is overexpressed in ovarian cancer and that binding of its cognate ligand, PGE2, will drive ovarian cancer progression and that inhibition of the EP4-mediated signaling will lead to inhibition of ovarian cancer growth and metastasis. In order to test these hypotheses, we analyzed the expression of the EP4 receptor in a human ovarian cancer tissue microarray (TMA) as well as human ovarian cancer cell lines. Immunohistochemical analysis of EP4 on the TMA composed of varying histologies, including serous, endometrioid and clear cell, as well as normal ovarian tissue revealed that EP4 was expressed in 38.7% of ovarian cancer patients; whereas, EP4 was not expressed in the 10 normal ovarian tissue samples. Additionally, in comparison to immortalized human ovarian surface epithelial (HOSE) cells, EP4 is overexpressed in many of the cell lines analyzed, including ES-2, OVCAR-3, COAV-3, SKOV3, OVISE and Kuramochi cells. Treatment of these cell lines with an EP4 antagonist resulted in decreased proliferation and migration compared to vehicle control. Consistent with the pharmacological data, treatment of ovarian cancer cell lines with siRNA directed against the EP4 receptor lead to decreased proliferation and migration. Based on these data, targeting of the PGE2 EP4 receptor should be investigated further for the treatment of ovarian cancer. Citation Format: Joceyln C. Reader, Paul Staats, Olga Goloubeva, Ningbo Jian, Dana M. Roque, Maya E. Matheny, Amy M. Fulton, Gautam G. Rao. Functional studies of the prostaglandin E2 receptor EP4 in ovarian cancer. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 5169. | 2022-07-03T02:52:13.480Z |
26,865,177 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1176/JNP.16.1.57",
"MAG": "2061936845",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | OBJECTIVE
Both early-onset Alzheimer's Disease (EOAD) and late-onset Alzheimer's Disease (LOAD) present with cognitive and psychiatric features. Some studies suggest that EOAD patients are more likely than LOAD patients to have psychiatric symptoms. If this is true, relatives of EOAD patients with a similar clinical presentation may be more likely to be misclassified as having a primary noncognitive psychiatric disorder rather than a dementing disorder. Family history studies may underestimate familial aggregation of EOAD.
METHODS
The authors compared the presence of psychiatric symptoms in parents and siblings of 131 EOAD patients (diagnosed at or before age 60), with the parents and siblings of 131 LOAD patients (diagnosed at or after age 65). Early onset Alzheimer's Disease and LOAD patients were matched for diagnosis (probable versus possible AD), gender, and ethnic group. Logistic regression analysis was performed on the outcome variable of patient group (EOAD, LOAD) with family history of psychiatric symptoms as the risk factor, adjusting for family size and patient's education.
RESULTS
There was a nearly two and one-half-fold increase in family history of psychiatric symptoms among EOAD patients when compared with LOAD patients (RR = 2.4; 95% C.I. 1.2-4.7).
CONCLUSIONS
The authors found preliminary evidence of a higher prevalence of a history of psychiatric symptoms among relatives of EOAD patients when compared to LOAD patients. This may be due to differential misclassification of AD, a syndromic disorder with both noncognitive psychiatric and cognitive deficits in relatives of EOAD patients. Alternatively, shared genetic or other familial etiologies may underlie subtypes of EOAD and some psychiatric disorders. | 2022-09-12T04:16:10.287Z |
253,496,483 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5005/jp-journals-10024-3378",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.5005/jp-journals-10024-3378"
} | AIM
The purpose of the study was to evaluate the stress on the implant and to assess the denture displacement for locator and bar and clip attachment types in implant-assisted obturators.
MATERIALS AND METHODS
A maxillary edentulous experimental model with a maxillectomy defect was made along with an opposing edentulous mandibular model with self-cure acrylic. Two endosseous implants were placed in the maxillary model. Corresponding obturator complete denture was fabricated for the maxillary model and a complete denture for the mandibular. The attachments were positioned on the implants in maxillary model, and their sleeve/clip was placed on intaglio surface of the dentures. The mounted articulator was placed on a loading apparatus, and force was incrementally applied to it. The strain and displacement for both the attachment types were measured and compared using Digital Image Correlation (DIC).
RESULTS
Locator attachment showed the least stress and minimal displacement as compared to bar and clip attachment.
CONCLUSION
The stresses around the implants and displacement of the obturator are affected by the attachment type used. It was found that bar and clip (splinted) showed the maximum stresses around the implant and maximum denture displacement. Locator attachment is the better choice over bar and clip because of its additional retentive features.
CLINICAL SIGNIFICANCE
The advantage of using DIC over the conventional strain gauge analysis is that a full-field data of displacement and strain can be obtained instead of getting a mean value on the small surface where the strain gauge is positioned. | 2022-11-29T07:18:42.813Z |
57,755,094 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TPS.2018.2879230",
"MAG": "2901598863",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Simulating the interaction of RF-waves with charged particle beams is difficult and computationally expensive, even on present high-end computers. There is a tradeoff between fidelity and complexity/expense of the two primary techniques, particle-in-cell and envelope methods. This paper presents an approach based on the partial decomposition of the Maxwell equations to achieve a fully second-order set of ordinary differential equations (ODEs) describing the interaction. It has the potential for self-consistent inclusion of ac and dc space-charge effects through a solution of evanescent ODEs, effects that are handled poorly, if at all, by existing envelope methods. The resulting technique provides flexibility in adjusting simulation fidelity versus computational costs. The developments presented in this paper establish a mathematical framework for this technique and test its core aspects by demonstrating accurate solution of the ODEs using analytic sources. | 2022-12-17T08:47:04.604Z |
22,929,072 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/hon.2349",
"MAG": "2529529439",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder of remarkable heterogeneity as demonstrated by cytogenetics and molecular analyses. Complex karyotype (CK), TP53 deletions and/or mutations (TP53 disruption), IGVH mutational status, and, more recently, recurrent somatic mutations have been identified as prognostic markers in CLL. On a cohort of 110 patients with CLL treated with first‐line fludarabin, cyclophosphamide, and rituximab treatment compared with 33 untreated (watch and wait) patients with CLL, we report more frequent complex karyotypes (34 vs 15%; P = .05), unmutated IGHV (70 vs 21%; P < .0001), ATM deletion (25 vs 6%, P = .02), and NOTCH mutation (3 vs 17%, P = .04). Among treated patients, 39 relapsed during the follow‐up period. These patients were characterized before treatment by a higher incidence of trisomy 12 (38 vs 11%, P < .001) and TP53 disruption (31 vs 4%, P = .0002). A significantly shorter 5‐year overall survival was found for treated patients with CK (72.4 vs 85.8%; P = .007), unmutated IGHV (70 vs 100%; P = .04), or TP53 disruption (55.7 vs 82.7%; P < .0001). Three risk groups were defined based on the status of TP53 disruption or unmutated IGVH, which differed significantly in terms of 5‐year overall survival. Moreover, the presence of CK impacted pejoratively 5‐year overall survival and progression‐free survival in all these 3 groups. Conventional karyotyping therefore appears to be of value, CK being an additional factor, undetectable in classical FISH, in patients with CLL at the stage when therapy becomes required. | 2022-12-20T21:53:01.271Z |
17,125,804 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1037/a0013835",
"MAG": "2006588281",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
} | In Experiment 1, students received an illustrated booklet, PowerPoint presentation, or narrated animation that explained 6 steps in how a cold virus infects the human body. The material included 6 high-interest details mainly about the role of viruses in sex or death (high group) or 6 low-interest details consisting of facts and health tips about viruses (low group). The low group outperformed the high group across all 3 media on a subsequent test of problem-solving transfer (d = .80) but not retention (d = .05). In Experiment 2, students who studied a PowerPoint lesson explaining the steps in how digestion works performed better on a problem-solving transfer test if the lesson contained 7 low-interest details rather than 7 high-interest details (d = .86), but the groups did not differ on retention (d = .26). In both experiments, as the interestingness of details was increased, student understanding decreased (as measured by transfer). Results are consistent with a cognitive theory of multimedia learning, in which highly interesting details sap processing capacity away from deeper cognitive processing of the core material during learning. | 2022-12-28T19:29:54.807Z |
228,856,386 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.20473/ijph.v15i3.2020.348-355",
"MAG": "3103834185",
"PubMedCentral": null
},
"license": "CCBYNCSA",
"status": "GOLD",
"url": "https://e-journal.unair.ac.id/IJPH/article/download/15529/pdf"
} | Fitness center / gymnasium is one of the sports favored by the public because in the fitness center has a range of tools and facilities that have been designed so that it can be used as a tool for physical exercise that right. So the longer the gymnasium has also become a necessity for people, Necessity (need) here are divided into two categories, felt or perceived (subject assessment) and evaluated (clinical diagnosis).This study uses a quantitative approach. While the survey research techniques are activities taking samples from a population and using questionnaires as the main data collection tool to understand the needs of students related Airlangga University gymnasium. The results of the study that students need a gymnasium facilities are only accessible by only academy person and in which there is a pool and a cafeteria. This may indicate that students are given follow the advice of doctors to perform the sport swim and is in accordance with the desired exercise by students. | 2022-01-27T08:31:43.094Z |
123,933,012 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.18454/IRJ.2016.45.168",
"MAG": "2366747809",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Закон Дарси выполняется в определенном диапазоне скоростей фильтрации. Существуют некоторые предельные градиенты давления, при которых меняется режим фильтрационного течения. Для определения нижней границы линейной фильтрации был рассмотрен общий случай фильтрации нелинейно-вязко пластичной жидкости. Произведен расчет для определения нижней границы применимости закона Дарси для месторождений, расположенных в пластах каменноугольного возраста. | 2022-02-09T18:32:30.652Z |
73,581,488 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1017/S0017089515000324",
"MAG": "2502322634",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Abstract Let R be an arbitrary ring. We introduce and study a generalization of injective and flat complexes of modules, called weak injective and weak flat complexes of modules respectively. We show that a complex C is weak injective (resp. weak flat) if and only if C is exact and all cycles of C are weak injective (resp. weak flat) as R-modules. In addition, we discuss the weak injective and weak flat dimensions of complexes of modules. Finally, we show that the category of weak injective (resp. weak flat) complexes is closed under pure subcomplexes, pure epimorphic images and direct limits. As a result, we then determine the existence of weak injective (resp. weak flat) covers and preenvelopes of complexes. | 2022-09-26T22:29:39.890Z |
252,619,712 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.33558/geographia.v1i1.2465",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Tujuan dari penelitian ini ingin mengetahui sejauhmana efektivitas kuliah kerja lapangan (KKL) dalam meningkatkan spatial thinking (berpikir spasial) pada mahasiswa pendidikan geografi FKIP Unisma Bekasi. Target luaran yang ingin dicapai adalah mengetahui sejauh mana efektivitas kuliah kerja lapangan dalam meningkatkan spatial thinking pada diri mahasiswa khususnya yang berada di program studi pendidikan geografi, sehingga dengan kuliah kerja lapangan ini akan mampu lebih meningkatkan kemampuan mahasiswa terutama dalam hal spatial thinking. Metode penelitian yang digunakan adalah metode survai dengan pendekatan kuantitatif dan teknik analisis korelasi, karena ingin mengetahui efektivitas Kuliah Kerja Lapangan (KKL) dalam meningkatkan Spatial Thinking. Populasi yang diambil adalah seluruh mahasiswa geografi angkatan 2016 dan 2017. Kegiatan yang akan dilakukan adalah dengan melakukan observasi dan juga survai ke mahasiswa program studi pendidikan geografi FKIP Unisma Bekasi angkatan 2016 dan 2017 untuk mengetahui sejauh mana efektivitas kuliah kerja lapangan dalam meningkatkan kemampuan berpikir spasial. | 2022-10-01T17:20:43.838Z |
118,015,043 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1063/1.3427388",
"MAG": "1513402450",
"PubMedCentral": null
},
"license": null,
"status": "GREEN",
"url": "http://ira.lib.polyu.edu.hk/bitstream/10397/2474/1/ApplPhysLett_96_182503.pdf"
} | We report experimentally and theoretically the effect of phase transformation on the converse magnetoelectric (CME) properties of a heterostructure formed by one layer of piezoelectric 0.7PbMg1/3Nb2/3O3-0.3PbTiO3 (PMN-PT) crystal sandwiched between two layers of ferromagnetic shape memory Ni49.2Mn29.6Ga21.2 (Ni–Mn–Ga) crystal. The CME coefficient (αB) of the heterostructure remains minimally and relatively constant in the martensitic phase ( 39 °C). Giant resonance αB of 18.6 G/V is found at 32 °C under a very low bias magnetic field of 150 Oe. | 2022-12-11T03:19:54.537Z |
222,182,663 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1001/jamanetworkopen.2020.15198",
"MAG": "3091778431",
"PubMedCentral": "7542300"
},
"license": "CCBYNCND",
"status": "GOLD",
"url": "https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2771396/liu_2020_oi_200570_1601426838.90364.pdf"
} | Key Points Question How is Medicaid expansion associated with the insurance status and treatment patterns among patients with higher-risk prostate cancer? Findings In this cohort study that included 15 332 men newly diagnosed with higher-risk prostate cancer, Medicaid coverage increased after expansion but was not associated with higher treatment rates at the population level after expansion or compared with uninsured patients. Meaning Although there was no difference in higher-risk prostate cancer treatment rates after Medicaid expansion in this study, it is important to continue addressing disparities in at-risk populations, given that insurance coverage alone is not sufficient to improve cancer care. | 2022-12-11T04:52:37.402Z |
18,967,793 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.4293/108680811X13022985132074",
"MAG": "1994443272",
"PubMedCentral": "3148865"
},
"license": null,
"status": null,
"url": null
} | These authors found that laparoscopic gastrojejunostomy for the management of gastric outlet obstruction can be performed with good outcomes and acceptable complication rates. | 2022-12-11T12:08:15.590Z |
141,970,011 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7146/ks.v4i2.15521",
"MAG": "1488776980",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://tidsskrift.dk/fn/article/download/15521/13409"
} | Folelseshistorie er et forskningsfelt i eksplosiv vaekst. Med udgangspunkt i vaesentlige nyere bidrag inden for historiefaget og kulturstudier diskuterer artiklen de centrale teoretiske problemstillinger, forskere konfronteres med, nar de vil undersoge folelser i forskellige historiske kontekster: Hvordan skal vi definere folelser? I hvor hoj grad er de socialt konstituerede og kulturelt specifikke? Er der noget naturgivent og universelt ved det menneskelige folelsesliv? Artiklen taler for at undersoge folelser som en form for praksis, der udspringer fra en social struktureret krop, og som pavirker de sociale sammenhaenge, hvori de udoves. Abstract The history of emotions is currently a rapidly expanding field. Probing a number of important recent contributions to the field, this article discusses the central theoretical and methodological challenges that researchers must confront when interrogating emotions in different historical contexts: How should we define emotions? To what extent are they socially constituted and culturally contingent? Is there anything universal about human emotional experience? The article makes the case that the greatest challenge for historians of emotion is to conceptualize emotions in a way that captures their social constitution while at the same time implies a principle of emotional changes over time. Taking Monique Scheer’s concept of ”emotional practices” as a starting point, the article argues that it could productively be combined with theories that point to the sociopolitical effects of emotions. This conceptualization makes it possible to shift the theoretical focus away from the emotions’ ontological status towards an analysis of how emotions are done and with what effects. Examining different empirical examples from postcolonial studies, the article finally shows how the concept of emotional practices is useful to think with in analyses of the sociopolitical implications of emotions. | 2022-12-16T15:19:14.635Z |
41,629,805 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1099/VIR.0.82744-0",
"MAG": "2100253631",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | In tumour cell lines established from Marek's disease (MD) lymphomas L-meq is consistently expressed. It contains a 180 bp insertion encoding additional copies of the proline-rich repeat in the meq open reading frame and its product may contribute to the maintenance of MD virus (MDV) latency. In this study, we identified a novel spliced form of the meq transcript in MD-derived lymphoblastoid cell lines and in MDV-infected cells. This transcript, termed Deltameq, encodes an N-terminal 98 aa of the Meq protein and lacks part of the basic leucine zipper (bZIP) and transactivation domains. In MD cell lines, transcription of L-meq was significantly downregulated, while that of the Deltameq transcript was upregulated during apoptosis. These observations were also confirmed at the protein expression level. Reporter assays using meq- and interleukin-2 (IL-2)-promoter-driven luciferase vectors revealed that DeltaMeq suppressed transactivation by L-Meq or Meq in a dose-dependent manner. Immunoprecipitation confirmed that DeltaMeq was associated with L-Meq or Meq physically. These results suggest that DeltaMeq could be involved in apoptosis in MD cell lines as it works as a negative regulator of L-Meq and Meq by direct interaction. | 2022-12-19T00:32:28.119Z |
15,971,684 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1364/BOE.4.001710",
"MAG": "2037376925",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Non-invasive reflectance imaging of the human RPE cell mosaic is demonstrated using a modified confocal adaptive optics scanning light ophthalmoscope (AOSLO). The confocal circular aperture in front of the imaging detector was replaced with a combination of a circular aperture 4 to 16 Airy disks in diameter and an opaque filament, 1 or 3 Airy disks thick. This arrangement reveals the RPE cell mosaic by dramatically attenuating the light backscattered by the photoreceptors. The RPE cell mosaic was visualized in all 7 recruited subjects at multiple retinal locations with varying degrees of contrast and cross-talk from the photoreceptors. Various experimental settings were explored for improving the visualization of the RPE cell boundaries including: pinhole diameter, filament thickness, illumination and imaging pupil apodization, unmatched imaging and illumination focus, wavelength and polarization. None of these offered an obvious path for enhancing image contrast. The demonstrated implementation of dark-field AOSLO imaging using 790 nm light requires low light exposures relative to light safety standards and it is more comfortable for the subject than the traditional autofluorescence RPE imaging with visible light. Both these factors make RPE dark-field imaging appealing for studying mechanisms of eye disease, as well as a clinical tool for screening and monitoring disease progression. | 2022-12-19T01:57:11.882Z |
196,516,148 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1056/NEJM-JW.NA49290",
"MAG": "2952124670",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | At this year's meeting of the American Society of Clinical Oncology (ASCO 2019), held May 31 to June 4 in Chicago, investigators discussed the latest | 2022-02-08T07:06:01.605Z |
119,574,037 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/00207177408932770",
"MAG": "1984148979",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Abstract In this letter an algorithm is presented which automatically generates all permissible combinations of minimal indices for a multivariate system of known order in a canonical state space form. The primary application of the algorithm is the automation of multivariable system identification methods ; the technique is however of general interest in multivariate system studios. | 2022-02-09T22:37:20.960Z |
11,192,209 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/500317.500323",
"MAG": "1587686666",
"PubMedCentral": null
},
"license": null,
"status": "CLOSED",
"url": null
} | The Social Web Cockpit integrates different services that have been developed in the Social Web research programme at GMD-FIT to support a knowledge sharing community. This includes a web-search based on recommendations, a concept index to develop a community vocabulary, shared workspaces for knowledge sharing, and an | 2022-02-13T05:35:30.653Z |
9,811,498 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ICASSP.2017.7952824",
"MAG": "2653114711",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | In this work, the inter-dependency of TCM signals is studied. Using this inter-dependency, correlation-based detectors are proposed for spectrum sensing of TCM signals in white Gaussian noise. In particular, a constant false alarm rate (CFAR) detector is presented and its performance is evaluated using simulations. We also describe an application of our detector for the classification of uncoded modulation systems vs. their TCM counterparts and present numerical results on their performance. | 2022-02-13T07:11:57.738Z |
18,137,203 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/IWCDM.2011.42",
"MAG": "1979870430",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | The present study examined the effects of pulse duration on the pulse repetition rate (PRR) processing in inferior collicular (IC) neurons of constant frequency¨Cfrequency modulation (CF-FM) bat (Hipposideros armiger), using CF-FM sound stimuli of 30+4, 15+3, and 5+2 ms. IC neurons were classified into 4 types: low pass (LP), band pass (BP), high pass (HP), and non-selective neurons. And the proportions of these four types changed with the sound duration decreasing. The LP, BP, and HP neurons might process information from echoes of search, approach, and catch phases, respectively, during bats hunting, while the non-selective neurons had no selectivity to PRR. Because the effects of sound duration on PRR selectivity were distinguishing in different IC neurons, we speculated that some neurons were likely to process their preferred PRRs at one phase of target approaching sequence, while others could adjust their following abilities to match constantly changing duration of sound signals. | 2022-09-27T22:10:13.518Z |
55,896,210 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5964/bioling.8831",
"MAG": "1538401235",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "https://bioling.psychopen.eu/index.php/bioling/article/download/8831/8025"
} | We distinguish three kinds of recursion: Direct Recursion (which delivers a ‘conjunction’ reading), Indirect Recursion, and Generalized Transformations. The essential argument is that Direct Recursion captures the first stage of each recursive structure. Acquisition evidence will then be provided from both naturalistic data and experimentation that adjectives, possessives, verbal compounds, and sentence complements all point to con-junction as the first stage. Then it will be argued that Indirect Recursion captures the Strong Minimalist Thesis, which allows periodic Transfer and interpretation. Why is recursion delayed and not immediate? It is argued that an interpretation of Generalized Transformations in the spirit of Tree Adjoining Grammar offers a route to explanation. A labeling algorithm combines with Generalized Transformations to provide different labels for recursive structures projection. Recursion is then achieved by substitution of a recursive node for a simple node. One simple case is to substitute a Maximal Projection for a simple non-branching lexical node. A more complex case — essential to acquisition — is to substitute a category for a lexical string. Consequently, a computational ‘psychological reality’ can be attributed to explain why recursion requires an extra step for the addition of each recursive construction on the acquisition path. | 2022-12-07T22:38:38.852Z |
12,903,531 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.23919/ECC.2013.6669271",
"MAG": "2056134761",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | In this paper, we propose an economic model predictive control (MPC) framework with a self-tuning terminal weight, which builds on a recently proposed MPC algorithm with a generalized terminal state constraint. First, given a general time-varying terminal weight, we derive an upper bound on the closed-loop average performance which depends on the limit value of the predicted terminal state. After that, we derive conditions for a self-tuning terminal weight such that bounds for this limit value can be obtained. Finally, we propose several update rules for the self-tuning terminal weight and analyze their respective properties. We illustrate our findings with several examples. | 2022-12-09T20:56:47.797Z |
68,399,966 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/adc.46.245.126-a",
"MAG": "641696044",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://adc.bmj.com/content/archdischild/46/245/126.2.full.pdf"
} | Contents Section 1 - Acute paediatrics Resuscitation * Cardiology * Child abuse and protection awareness * Endocrinology * Fluid and electrolyte therapy * Gastrointestinal and liver problems * General paediatrics * Haematology * Infections * Inherited metabolic disorders * Neonatology * Neurology and neurosurgery * Oncology * Poisoning * Renal medicine * Respiratory medicine * Rheumatology * Sudden unexpected death in infancy * Surgery Section 2 - Outpatient and specialty paediatrics Child development * Dermatology * Education * Emotional and behavioural problems * Endocrine and growth * Gastroenterology * Haematology * Nocturnal enuresis * Neurology * Respiratory including cystic fibrosis * Rheumatology Section 3 - Prescribing Corticosteroids * Oral sedation * Pain in children * The formulary Section 4 - Information and normal values Reference values * Child law * Cultural awareness * How to read a paper * Immunization * Nutrition * Surgical issues * Useful websites and addresses Section 5 - Dictionary of eponymous syndromes and diseases | 2022-09-06T08:34:46.478Z |
126,043,784 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/oso/9780198822370.003.0012",
"MAG": "2888306716",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | In this chapter, the theory of near-equilibrium oscillations is developed and normal mode analysis is performed. This topic requires a little bit of linear algebra when dealing with matrices, as well as an understanding of differential equations. The chapter explores small perturbations (small nudges or tiny shifts) to a stable equilibrium point in configuration space and introduces the characteristic equation. Interdisciplinary examples are then investigated, including a surface science example in which the bond frequencies of surface adsorbates are calculated, an example in which the motion of atoms in a triatomic molecule is examined and an example in which the molecular physics of atomic force microscopy is analysed. The properties of the eigenvalue problem for small oscillations are also investigated. | 2022-02-09T16:28:16.179Z |
70,503,282 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1055/S-0038-1622999",
"MAG": "1544423984",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Mastdarmverletzungen oder -rupturen konnen iatrogen anlasslich einer rektalen Untersuchung, aber auch durch andere Ursachen wie z. B. durch transanale Fehlbedeckun-gen, Schwergeburten, Beckenfrakturen, Verletzungen durch Fremdkorpereinwirkung oder sadistische Manipula-tionen entstehen. Die meisten iatrogen verursachten Rek-tumverletzungen haben einen zur Darmachse gelegenen longitudinalen Verlauf und finden sich vornehmlich im dor-salen Ampullendach des Rektums, wo dieses in das Colon descendens ubergeht. Sehr selten sind dagegen spontan auftretende idiopathische Rektumrupturen. Ursachen, die zu dieser Verletzungsform fuhren, sind zunachst unklar, mit-hilfe einer Sektion sowie einer histologischen Untersuchung konnen sie unter Umstanden ermittelt werden. Anhand der Krankengeschichten von funf Pferden mit einer idiopathischen Mastdarmruptur aus dem Patientengut der Tierklinik Hochmoor wird auf das Krankheitsbild eingegan-gen. Vier Patienten wurden mit Kolik uberwiesen, bei einem Tier trat die Ruptur wahrend einer Lahmheitsuntersuchung in der Klinik auf. Auffallend war, dass die Rupturlinien kei-nen longitudinalen, sondern einen eher zirkularen Verlauf unterschiedlichen Ausmases aufwiesen. Bei vier Patienten, die euthanasiert wurden, hatte die Ruptur die Bauchhohle eroffnet, bei einem, der nach sechs Wochen als geheilt entlassen wurde, lag sie retroperitoneal. Da die Rupturen immer unbemerkt entstehen, kann eine Therapie nur mit Verzogerung beginnen. Die Behandlungs-moglichkeiten richten sich nach Lokalisation und Ausmas der Verletzung: konservative und/oder chirurgische Mas-nahmen konnen erfolgen. | 2022-09-03T19:58:07.471Z |
218,832,414 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1188/20.CJON.S1.16-23",
"MAG": "3028275449",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | BACKGROUND
Rural and urban communities may encounter barriers to care, which can lead to delays in timely screening, diagnosis, and treatment. eHealth interventions, such as televisits and remote patient monitoring, are being used increasingly to improve patient access to quality clinical cancer care and to support patient-provider communication.
OBJECTIVES
This article describes how eHealth can bridge gaps in patient access to cancer care and provides insight into successful eHealth program implementation.
METHODS
Articles that evaluate access to care and eHealth program implementation were summarized. Two case studies illustrate eHealth as a strategy to improve care delivery and access.
FINDINGS
Integrating eHealth into clinical practice can help to transform care delivery and improve patient access to quality cancer care by limiting barriers. | 2022-09-05T03:56:57.220Z |
24,289,211 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1364/OL.21.001615",
"MAG": "2033235230",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | We describe a digital holographic data storage system that uses in situ thermal fixing to achieve nonvolatile readout. The system was used to store and fix 530 holograms representing 1.7 MB of digital data. The system demonstrates that fixing by heating after recording gives adequate performance for multiplex holography in the perpendicular recording geometry. The postrecording heating procedure is preferred over high-temperature recording in the perpendicular geometry to achieve Bragg matching for the entire signal angular bandwidth. | 2022-09-23T13:55:48.844Z |
55,198,038 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1155/2017/1262309",
"MAG": "2742094761",
"PubMedCentral": null
},
"license": "CCBY",
"status": "GOLD",
"url": "http://downloads.hindawi.com/journals/jnm/2017/1262309.pdf"
} | Cell type, morphology, and functioning are key variables in the construction of efficient “drug-vehicle” hybrids in magnetic drug delivery. Iron-encapsulated multiwall carbon nanotubes (Fe@MWCNTs) appear as promising candidates for theranostics due to in situ chemical catalytic vapor deposition (c-CVD) synthesis, straightforward organic functionalization, and nanoneedle (1D) behavior. Here, model hybrids were synthesized by exploring C-sp2 chemistry ((1 | 2022-11-03T06:35:15.209Z |
103,046,724 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1002/cctc.201701763",
"MAG": "2778140189",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | The detailed mechanism of catalytic conversion of CO2 and ethylene to acrylic acid has been investigated through DFT and DLPNO‐CCSD(T) calculations. Four bidentate ligands, dmpe (1,2‐bis(dimethylphosphino)ethane), dcpe (1,2‐bis(dicyclohexylphosphino)ethane), dtbpe (1,2‐bis(di‐tert‐butylphosphino)ethane), and tmeda (tetramethylethylenediamine) were systematically studied to understand the different catalytic behavior of the Pd‐based catalyst and the well‐known Ni‐based catalyst. The energy barrier of Pd‐/Ni‐catalyzed C−C coupling appears to increase with the larger steric hindrance of the ligand, whereas the barrier of the corresponding β‐H elimination shows an opposite tendency. The barrier for C−C coupling is likely higher than the associated barrier for β‐H elimination in both catalytic systems provided that the coordinated ligand is bulky enough. The palladium catalytic center is more effective than the nickel center for the C−C coupling and β‐H elimination steps in the presence of bulky ligands, whereas the nickel catalyst in turn performs better with small ligands. The palladium catalyst tends to be superior to the nickel catalyst during the following hydrogen transfer to the O atom. In general, the diamine ligand (tmeda) is less efficient than the diphosphine ligands for both systems. In the absence of the auxiliaries, a novel chelating carbene ligand was proposed to be quite efficient for Pd‐catalyzed C−C coupling. Two ligands (dcpm, dtbpm) showed relatively better performance towards the palladium‐catalyzed acrylic acid formation reaction among all the investigated ligands. | 2022-12-09T11:36:10.076Z |
7,582,319 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/PEDG.2015.7223071",
"MAG": "1505736273",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | This paper deals with the advantages of GaN devices for bidirectional battery chargers for plug-in hybrid electric vehicles and electric vehicles that are connected to the singlephase European ac grid. Compared to a charger with silicon devices a higher power density can be realized because of the lower switching losses of GaN devices that enable higher switching frequencies. A state-of-the-art battery charging systems will be described and the differences and advantages of fast switching GaN devices compared to standard silicon ones will be pointed out. The presented topology allows bidirectional power flow. Therefore, this charger can be used to stabilize the utility grid. An overview of the different components of the battery charger and their design aspects are presented in this paper. | 2022-12-10T17:33:41.779Z |
142,912,957 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1111/J.1536-7150.2005.00385.X",
"MAG": "1568711962",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Once in a while a fundamental misunderstanding gets into print. Sometimes it takes a considerable amount of effort and tons of ink and paper to correct the mistake. Sometimes the correction never gets made. In the case of George Reisman's (2004) fundamental misreading of modern macroeconomists' definition of the gross domestic product (GDP) or gross national product (GNP), it should be easy to correct it quickly. Reisman's problem is that he attributes his own confusion to others and then tries to correct them. He does not correctly distinguish between intermediate goods and factors of production, and he also does not correctly recognize how macroeconomists derive the net domestic or national product from the gross product. Finally, his concept of gross national revenue is grossly mistaken. If Reisman has impressed upon students his profound misreading of the process of national income accounting, this journal owes them an early opportunity to clear their minds of the confusion. Reisman charges that "the accusation of 'double counting' should actually be directed at the prevailing conviction that the value of the final product counts not only itself but also the value of the intermediate products that have contributed to its production" (2004: 615q516). National income accountants don't say that the value of the final product counts itself plus the value of intermediate products. None of the nine quotations he cites (2004: 610-611) should be interpreted as he does. What is stated in national income accounting is that the value of the final product already includes or covers the value of the intermediate goods. Using Reisman's own example of a loaf of bread that sells for $6, having been produced with flour costing $5, and the latter having been derived from wheat costing $3, what macroeconomists say is that the $6 value of the bread covers the cost of the flour. Furthermore, the cost of flour covers the cost of wheat. That is why one does not have to add the cost or value of wheat to that of flour and then to the value of bread in order to correctly estimate national income or product. From the value-added approach to national income accounting, we would obtain the $6 by adding the $3 from the farmer's effort, $2 from the miller's effort, and $1 from the baker's effort or production. The values added in the process of creating bread by the farmer, the miller, and the baker also constitute the net incomes of those enterprises--wheat farming ($3), flour milling ($2), and bread baking ($1). Now, if to obtain Reisman's allegedly correct measure of gross domestic product one added all these incomes to the value of the bread ($6), there would be more domestic or national income than producers actually received. It is to avoid this embarrassing overestimation that national income accounting instructs that one may use either the value-added approach or the expenditure approach, but to be careful to add only the expenditures on final demand or end use in the latter approach, and not to include intermediate goods. It is totally mistaken to be worrying about factor costs--wages of labor, rent of land or equipment, interest on borrowed capital (funds or savings), profits to entrepreneurship--in the above attempts at national income accounting as Reisman appears to be doing (see his note 16). At the various stages of producing the bread, the net incomes (revenues) received are distributed into wages, rents, interest, and profits (or losses) to the respective factors engaged in the production process. This understanding should make it abundantly clear how wrong Reisman is in his attempt to add the value of wages to "business sales revenues" in order to obtain his so-called gross national revenue (GNR) (2004: 619). It is from sales revenues that wages are (ultimately) paid. It makes no good sense to add production costs to sales revenues in order to estimate national income or product. Indeed, a third approach to national income accounting is to add all factor incomes--wages, interest, rentals, and profits. … | 2022-12-15T08:26:55.822Z |
88,743,372 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/03650340.2016.1177176",
"MAG": "2463196922",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | ABSTRACT In this research, the influence of climate change on maize cultivation was investigated and then, the possible solutions for adopting this natural hazard in the coasts of Caspian Sea in Iran was assessed. Weather data were generated for the 2011–2100 period using a statistical downscaling model under different climatic scenarios. Reference evapotranspiration (ETo) was calculated using a Neuro-fuzzy inference system. Cop water requirement was calculated by multiplying ETo by crop coefficients. Increased cardinal temperatures during 2011–2100 led to shifting in the planting date backward by 10–26 days. In addition, the projected global warming has a considerable effect on the duration of the vegetative growth stage resulting in earlier harvesting. However, the duration of the reproductive stage is less affected. Despite the obvious reduction in the length of the growing season, crop water requirement will increase by 10.6–15.3% in the future due to 1.64–28.4% increase in ETo. However, changing the cultivation time may lead to 11.2–264.5 m3 ha−1 water saving during the whole cropping cycle through affecting both ETo and the crop growth cycle. This result demonstrates that management of the maize cropping calendar can be an effective way to achieve sustainable agriculture under future climate conditions in the study area. | 2022-12-29T05:38:41.322Z |
71,437,256 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/146642402104200514",
"MAG": "1988695986",
"PubMedCentral": null
},
"license": "CC0",
"status": "GREEN",
"url": "https://zenodo.org/record/1550564/files/article.pdf"
} | Dr. Truby King’s Method for the Preservation and Restoration of the Breast Milk, adapted for District Use. By Miss HESTER VINEY, Health Visitor, Battersea. (SUMMARY.) EVERY mother can, if she will, suckle her child. ~ The preparations for breast feeding begin in the ante-natal period, and are both mental and physical. The critical periods of nursing can be overcome by a simple routine of healthy living. The breast milk can always be restored if the weaning has not taken place over too long a period. Methods of restoration include water drinking by the mother, with the regular stimulation from the suckling of the child, and in some cases a little supplementary feeding as well. It is vital to the health of the race that the babies be breast fed for the first nine months. | 2022-07-04T09:48:06.925Z |
129,329,625 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1190/1.1440021",
"MAG": "2118807437",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | The apparent resistivity curves obtained from the magnetotelluric field measurements at the University of Alberta Geophysical Observatory, near Leduc, Alberta, reveal a strong anisotropy. The significance of the direction of the incident magnetic field in interpreting the structure from the apparent resistivity curves is examined in detail for the case of a linearly polarized incident field.The tensor impedance analysis of the data indicates that the directions of the principal axes of anisotropy are aligned parallel to the north-south and east-west measuring axis. The high coherency between the orthogonal horizontal components of the incident magnetic field is in complete agreement with this interpretation.The two apparent resistivity curves are interpreted and an anisotropic layered model is derived. The anisotropy is found to lie in the Precambrian basement down to a depth of 14 km. The isotropic upper layer has a resistivity of 8 ohm-m which is characteristic of the sedimentary section. The anisotropic resistivity structure proposed for the Precambrian basement may be attributed either to local lithological changes in the basement or to major but more distant structure. | 2022-09-10T23:22:09.307Z |
95,316,098 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/01919519408552418",
"MAG": "1999531658",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Abstract This article presents a simple, rapid and efficient laboratory method permittingone to simulate the effects of ozonation (OZOTEST method) or of an oxidation by combined ozone/hydrogen peroxide (PEROXOTEST method) on an industrialscale. A critical analysis of the method is made (ozone transfer, validity of the results) and several practical applications are submitted for consideration (ozone demand, oxidation of atrazine and the DOC). | 2022-09-11T00:45:52.912Z |
205,800,381 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1097/MEJ.0000000000000287",
"MAG": "2416151182",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | dence of admission hyperglycaemia and the association of admission hyperglycaemia with mortality in patients with hip fracture, they showed that a high admission blood sugar level (aBSL) was an indicator of in-hospital mortality. Other than the limitations described in the discussion, however, several issues that were not well addressed in this retrospective analysis might have made interpretation of their results questionable. | 2022-12-03T13:51:32.903Z |
150,248,224 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1080/09658416.2018.1434921",
"MAG": "2799784614",
"PubMedCentral": null
},
"license": "CCBYNCND",
"status": "GREEN",
"url": "https://research.wu.ac.at/ws/files/19747063/Stegu_etal_2018_LA_Panel-discussion.pdf"
} | As already mentioned in our introduction, the disciplinary status of Language Awareness (research), especially its relationship to other subfields of (Applied) Linguistics or also nonlinguistic disciplines still seems rather vague. Even if disciplines never reach a definitive, crystallised, final status, and there is and has to be a perpetual dynamic in the social construction of the system of sciences and disciplines, a ‘meta-disciplinary’ discourse remains important for every (potential) discipline and its identity. In the previous conference special issue, Agneta Svalberg published an important overview ‘Language Awareness research: where we are now’ (Svalberg, 2016), where she presented the most prominent LA topics and most frequently used research methods in the contributions of this journal in the years 2010 – 2014. Her analysis and considerations concern however rather internal aspects of LA research and not disciplinary issues. As in the last years I have been personally involved not only in the LA, but also in the Folk Linguistics community (co-convening with Antje Wilton the AILA Research Network ‘Folk Linguistics’; cf. Wilton & Stegu, 2011; AILA = Association Internationale de Linguistique Appliqu ee), I have been increasingly interested in the mutual relationship between Language Awareness, Folk Linguistics and Applied Linguistics. Therefore, I decided to organise at the Vienna conference a forum of experts from the different communities who would discuss the disciplinary issues mentioned above. The participants in this discussion were: Claire Kramsch, the (in the meantime: past) president of AILA, Dennis Preston, one of the most prominent researchers in ‘Folk Linguistics’ (cf. Niedzielski & Preston, 2000), Antje Wilton (see above) and myself, as moderator. Unfortunately, for reasons of time, Claire Kramsch was not able to compose a written version of her contribution, but we got texts from all the other participants. The oral and written versions were both reactions to an input text I had sent the participants before the conference, and at the beginning of the panel, as an introduction, I read the same text to the audience in order to present my questions. I will also copy the original text here before inserting the discussants’ statements. At the end of these statements, I will sum up with a provisional conclusion. LANGUAGE AWARENESS, 2018 VOL. 27, NOS. 1–2, 186–196 https://doi.org/10.1080/09658416.2018.1434921 | 2022-12-10T09:28:43.630Z |
37,522,756 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ISSCC.1980.1156095",
"MAG": "2074860662",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | The computer-aided design segment of the IC industry has had some success with tools to help with the LSI design problem. Particularly, circuit and logic simulation, layout graphics, and design rule checking have been very useful. Other areas, such as testing and modeling, continue to present challenges at the LSI level. As VLSI structures become a reality, new magnitudes of CAD tools will be needed. Can existing tools be scaled to solve the problem or will new approaches be required? | 2022-12-20T11:57:10.602Z |
53,005,055 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1139/F09-083",
"MAG": "2169056247",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | We investigated patterns of primary production across prairie saline lakes in the central and northern Great Plains of the United States. Based on comparative lake sampling in 2004, seasonal predictors of algal primary productivity were identified within subsets of similar lakes using a combination of Akaike's information criterion (AIC) and classifica- tion and regression trees (CART). These models indicated complex patterns of nutrient limitation by nitrogen (N), phos- phorus (P), and iron (Fe) within different lake groups. Nutrient enrichment assays (control, + Fe, + N, + P, + N + P) were performed in spring and summer of 2006 to determine if phytoplankton in selected lakes followed predicted patterns of nu- trient limitation. Both the comparative lake sampling and experimental results indicated that N limitation was widespread in these prairie lakes, with evidence for secondary P limitation in certain lakes. In the experiments, iron did not stimulate primary production. Our results suggest that given the diverse geochemical nature of these lakes, classification models that separate saline lakes into subsets may be an effective method for improving predictions of algal production. Resume´ : Nous avons etudieles patrons de production primaire dans des lacs sales de prairie repartis dans le centre et le nord des Grandes Plaines des Etats-Unis. Apartir d'un echantillonnage comparatif des lacs en 2004, nous avons identifie ´ les variables predictives saisonnieres de la production primaire des algues dans des sous-ensembles de lacs en utilisant conjointement le critere d'information d'Akaike (AIC) et des arbres de classification et de regression (CART). Ces mod- eles identifient des patrons complexes de limitation par les nutriments d'azote (N), de phosphore (P) et de fer (Fe) dans les differents groupes de lacs. Nous avons fait des tests d'enrichissement de nutriments (temoin, + Fe, + N, + P, + N + P) au printemps et al'ete ´ 2006 afin de determiner si le phytoplancton dans les lacs selectionnes suivait les patrons predits de limitation par les nutriments. Tant l'echantillonnage comparatif des lacs que les resultats experimentaux indiquent que la limitation par N est commune dans ces lacs de prairie, avec des indications d'une limitation secondaire par P dans certains lacs. Dans les experiences, le fer ne stimule pas la production primaire. Nos resultats indiquent qu'etant donnela nature geochimique diverse de ces lacs, les modeles de classification qui separent les lacs sales en sous-ensembles peuvent etre des methodes efficaces pour ameliorer les predictions de production des algues. (Traduit par la Redaction) | 2022-12-20T21:47:22.332Z |
208,212,500 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/ACCESS.2019.2953259",
"MAG": "2986274801",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Vessel segmentation has come a long way in terms of matching the experts at detection accuracy, yet there is potential for further improvement. In this regard, the accurate detection of vessels is generally more challenging due to the high variations in vessel contrast, width, and the observed noise level. Most vessel segmentation strategies utilize contrast enhancement as a preprocessing step, which has an inherent tendency to aggravate the noise and therefore, impede accurate vessel detection. To alleviate this problem, we propose to use the state-of-the-art Probabilistic Patch-Based (PPB) denoiser within the framework of an unsupervised retinal vessel segmentation strategy based on the Frangi filter. The PPB denoiser helps preserve vascular structure while effectively dealing with the amplified noise. Also, the modified Frangi filter is evaluated separately for tiny and large vessels, followed by individual segmentation and linear recombination of the binarized outputs. This way, the performance of the modified Frangi filter is significantly enhanced. The performance evaluation of the proposed method is evaluated on two recognized open-access datasets, viz: DRIVE and STARE. The proposed strategy yields competitive results for both preprocessing modalities, i.e., Contrast Limited Adaptive Histogram Equalization (CLAHE) and Generalized Linear Model (GLM). The performance observed for CLAHE over DRIVE and STARE datasets is (<inline-formula> <tex-math notation="LaTeX">$Sn = 0.8027$ </tex-math></inline-formula>, <inline-formula> <tex-math notation="LaTeX">$Acc = 0.9561$ </tex-math></inline-formula>) and (<inline-formula> <tex-math notation="LaTeX">$Sn = 0.798$ </tex-math></inline-formula>, <inline-formula> <tex-math notation="LaTeX">$Acc = 0.9561$ </tex-math></inline-formula>), respectively. For GLM, it is observed to be (<inline-formula> <tex-math notation="LaTeX">$Sn = 0.7907$ </tex-math></inline-formula>, <inline-formula> <tex-math notation="LaTeX">$Acc = 0.9603$ </tex-math></inline-formula>) and (<inline-formula> <tex-math notation="LaTeX">$Sn = 0.7860$ </tex-math></inline-formula>, <inline-formula> <tex-math notation="LaTeX">$Acc = 0.9583$ </tex-math></inline-formula>) over DRIVE and STARE datasets, respectively. Furthermore, based on the conducted comparative study, it is established that the proposed method outperforms various notable vessel segmentation methods available in the existing literature. | 2022-12-30T00:32:16.607Z |
194,236,899 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.33050/CCIT.V8I1.269",
"MAG": "2943099385",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Salah satu hal penting dalam suatu media visual lembaga institusi terhadap publik adalah sebuah identitas logo. Identitas logo sendiri memiliki arti sebagai identitas yang mewakili image sebuah lembaga institusi. Raharja Enrichment Centre adalah Divisi yang ditugaskan untuk melengkapi pelaksanaan Tri Dharma pada Perguruan Tinggi Raharja yang berkonsentrasi pada penelitian dan pengabdian untuk masyarakat. Program-program Raharja Enrichment Centre yang dikeluarkan selama ini belum memiliki sebuah identitas logo. Tanpa adanya identitas logo pada program-programnya belum bisa mewujudkan identitas kepemilikan kepada publik. Untuk itu, dibutuhkan identitas logo untuk setiap program-program Raharja Enrichment Centre yang dapat menarik dan dapat diimplementasikan sebagai identitas visualnya. Salah satu Methode yang digunakan dalam penelitian ini adalah menggunakan Metode Analisa Perancangan dengan dipergunakan aplikasiaplikasi penunjang diantaranya aplikasi Adobe Illustrator CS5 sebagai pengolah rancangan objek-objek gambar vector, sertaaplikasi Adobe Photoshop CS5 dipergunakan untuk mengolah gambar bitmap dan Konsep Desain berisi mengenai Perencanaan media. Dengan adanya identitas logo dari setiap program-program tersebut, publik akan mudah memahaminya dengan melihat sebuah tampilan yang konsisten dan mudah dikenali karena memiliki karakteristik khusus pada setiap program-programnya. Dari hasil rancangan identitas logo tersebut diharapkan untuk tahun-tahun berikutnya dapat memberikan suatu tampilan yang berbeda dan menarik dalam memperkenalkan program-program Raharja Enrichment Centre tersebut. | 2022-01-27T02:01:48.060Z |
89,648,397 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.7751/TELOPEA11767",
"MAG": "2763114191",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Hydrocotyle serendipita A.J.Perkins sp. nov. is a rare species of fire ephemeral from the Albany area of southwest Western Australia. The newly discovered species shares the fire ephemeral life history trait with the recently described H. phoenix A.J.Perkins. Based on a suite of vegetative synapomorphies, these two species appear to be closely related. Marked differences in mericarp shape and surface morphology, assist to differentiate the two species. Photographic images of H. serendipita are provided, along with a distribution map and a list of diagnostic features to aid in identification. | 2022-02-11T01:23:46.318Z |
253,164,776 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3389/fnmol.2022.1026530",
"MAG": null,
"PubMedCentral": "9649808"
},
"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fnmol.2022.1026530/pdf"
} | Wiedemann-Rautenstrauch syndrome (WDRTS) is an extremely rare autosomal recessive neonatal disorder. Currently, over 50 cases with variable phenotypes of WDRTS have been reported. In our cohort of prenatal and postnatal growth retardation, a female proband was found to have general growth retardation, neurocutaneous syndrome, and anemia. Karyotype test and array-CGH detected no obvious chromosomal aberrations. Trio-based whole-exome sequencing (Trio-WES) identified bi-allelic compound mutations in the coding sequence (CDS) of POLR3A gene (c.3342C > T, p.Ser1114 = and c.3718G > A, p.Gly1240Ser). For the mild anemia phenotype, the underlying causal genetic factors could be attributed to the compound heterozygous mutations in FANCA gene (c.2832dup, p.Ala945CysfsTer6 and c.1902 T > G, p.Asp634Glu). Mini-gene reporter assays revealed that the synonymous variant of POLR3A and the missense variant of FANCA could affect pre-mRNA splicing of each gene. For POLR3A, the synonymous mutation (c.3342C > T, p.Ser1114=) generated three types of aberrant isoforms. Therefore, the female patient was finally diagnosed as WDRTS caused by POLR3A. For FANCA, the missense variant (c.1902 T > G, p.Asp634Glu) disrupted the normal splicing between exon 21 and 22, and produced two types of abnormal isoforms, one carrying the 1902G and the other spliced between exon 21 and 23 to exclude exon 22. Network analysis showed that POLR3A and FANCA could be STRINGed, indicating both proteins might collaborate for some unknown functions. Current investigation would broaden the knowledge for clinicians and genetic counselors and remind them to interpret those synonymous or predicted “benign” variants more carefully. | 2022-11-25T01:20:47.411Z |
6,219,167 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1136/adc.40.214.687",
"MAG": "1984713392",
"PubMedCentral": null
},
"license": null,
"status": "BRONZE",
"url": "https://adc.bmj.com/content/40/214/687.full.pdf"
} | Case 1. A male infant, birth weight 6 lb. 6 oz. (2,891 g.), had a lumbar meningomyelocele which was repaired on the second day of life. At the age of 10 days, the infant's anterior fontanelle was tense and an air ventriculogram showed some dilatation of the lateral ventricles. However, subsequent head growth was not excessive, and by 5 months the skull circumference was 171 in. (44 cm.). At the age of 2 months the child developed laryngeal stridor which worsened over a period of one week. Laryngoscopy revealed no local cause for this symptom, but two weeks later tracheostomy was necessary for severe respiratory obstruction. Following operation, there were repeated episodes of vomiting and respiratory infection. It was six months before the infant could manage without the tracheostomy tube. Stridor has not recurred and the infant remains well without evidence of hydrocephalus. The only abnormality is paralytic talipes of the left foot. | 2022-12-10T09:01:44.137Z |
52,049,429 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2312/cgvc.20161305",
"MAG": "2543487594",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Olfactory displays provide a means to reproduce olfactory stimuli for use in virtual environments. Many of the designs produced by researchers, strive to provide stimuli quickly to users and focus on improving usability and portability, yet concentrate less on providing high levels of accuracy to improve the fidelity of odour delivery. This paper provides the guidance to build a reproducible and low cost olfactory display which is able to provide odours to users in a virtual environment at accurate concentration levels that are typical in everyday interactions; this includes ranges of concentration below parts per million and into parts per billion. This paper investigates build concerns of the olfactometer and its proper calibration in order to ensure concentration accuracy of the device. An analysis is provided on the recovery rates of a specific compound after excitation. This analysis provides insight into how this result can be generalisable to the recovery rates of any volatile organic compound, given knowledge of the specific vapour pressure of the compound. | 2022-12-10T10:20:38.070Z |
124,575,803 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1103/PHYSREVB.90.214415",
"MAG": "2321504423",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | The anisotropic magnetoresistance (AMR) in epitaxial $\mathrm{Pt}/\mathrm{Fe}/\mathrm{MgO}(001)$ bilayers was systematically studied as a function of Pt thickness, and a strong enhancement of AMR by the $\mathrm{Pt}$ layer was observed. The enhancement of AMR persists with a 1 nm Au layer inserted between $\mathrm{Pt}$ and Fe but disappears with a 1 nm $\mathrm{MgO}$ inserted layer. Both the spin Hall magnetoresistance theory and induced $\mathrm{Pt}$ moments located at the $\mathrm{Fe}/\mathrm{Pt}$ interface cannot explain the observed AMR enhancement. The enhanced AMR in the $\mathrm{Pt}/\mathrm{Fe}$ bilayer can be attributed to the $\mathrm{Pt}$ magnetic moment in the conduction band induced by the spin-polarized conduction electron, which has a long decay length of $1.7\text{\char21{}}2.6\phantom{\rule{4.pt}{0ex}}\text{nm}$. | 2022-12-13T02:12:01.511Z |
1,567,217 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/2813448.2813517",
"MAG": "2080997794",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | The goal of RecSys Challenge 2015 [2] is: (1) to predict which user will end up with a purchase and if so, (2) to predict items that he/she will buy given click/purchase data provided by YOOCHOOSE. It is hard to achieve the goal of this Challenge because (1) the data does not contain user demographics information and it contains a lot of missing values and (2) the volume of the dataset is massive with about 33 million clicks and 1 million purchase history and the class distribution (the ratio of non-purchased clicks to purchased clicks) is highly imbalanced. In order to efficiently solve these problems, we propose (1) Comprehensive Feature Engineering method (CFE) including imputation of missing values to make up for insufficiency of information and (2) Decision Boundary Focused Under-Sampling method (DBFUS) to cope with class imbalance problem and to reduce learning time and memory usage. Our proposed approach obtained 54403.6 points on the final leaderboard. | 2022-12-15T23:31:59.532Z |
41,244,369 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1128/MCB.00474-16",
"MAG": "2525388752",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | ABSTRACT Cell death and survival signaling pathways have opposed but fundamental functions for various cellular processes and maintain cell homeostasis through cross talk. Here we report a novel mechanism of interaction between these two pathways through the cleavage of RNF31 by caspases. RNF31, a component of the linear ubiquitin chain assembly complex (LUBAC), regulates cell survival by inducing linear ubiquitination of NF-κB signaling components. We found that RNF31 is cleaved under apoptosis conditions through various stimulations. The effector caspases caspase 3 and caspase 6 are responsible for this event, and aspartates 348, 387, and 390 were identified as target sites for this cleavage. Cleavage of RNF31 suppressed its ability to activate NF-κB signaling; thus, mutation of cleavage sites inhibited the induction of apoptosis by treatment with tumor necrosis factor alpha (TNF-α). Our findings elucidate a novel regulatory loop between cell death and the survival signal and may provide guidance for the development of therapeutic strategies for cancers through the sensitization of tumor cells to death-inducing drugs. | 2022-12-23T02:26:38.963Z |
108,293,654 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1109/TNNLS.2019.2904253",
"MAG": "2925818175",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | In this paper, an event-based distributed cooperative learning (DCL) law is proposed for a group of adaptive neural control systems. The plants to be controlled have identical structures, but reference signals for each plant are different. During control process, each agent intermittently broadcasts its neural network (NN) weight estimation to its neighboring agents under an event-triggered condition that is only based on its own estimated NN weights. If communication topology is connected and undirected, the NN weights of all neural control systems can converge to a small neighborhood of their optimal values. The generalization ability of NNs is guaranteed in the event-triggered context, that is, the approximation domain of each NN is the union of all system trajectories. Furthermore, a strictly positive lower bound on the interevent intervals is also guaranteed to avoid the Zeno behavior. Finally, a numerical example is given to illustrate the effectiveness of the proposed learning law. | 2022-12-21T19:08:38.479Z |
203,422,058 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.3406/cchav.1999.1227",
"MAG": "2972540422",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Les deux romans de jeunesse de Shelley, Zastrozzi et St Irvine, ecrits a dix-neuf ans, dans un moment de desarroi, sont exemplaires de la fonction creatrice de l’œuvre pour un auteur ; l’œuvre construit sa psyche. Ecrivant, il se sent vivant. L’ecriture met en effet au jour, a l’insu de l’auteur, un impense ; le malaise interieur s’inscrit et le drame interieur se decouvre apres-coup. Zastrozzi est une affirmation triomphale, une victoire de l’«humilie offense», rejete par son pere. St Irvyne, avec les chapitres manquants, les poemes effaces par les personnages du roman, represente un malaise plus profond, indicible, le sentiment de ne pas exister. | 2022-01-27T01:36:03.752Z |
208,324,352 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1177/875512259200800113",
"MAG": null,
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Gary W. Erwin, Pharm.D., is the 1991 recipient of the American So ciety of Consultant Pharmacists' (ASCP) George F. Archambault Award. ASCP's highest honor, this award is presented each year to an individual who is deemed by his colleagues to have demonstrated consistently exemplary perfor mance in the profession of consul tant pharmacy. Erwin is senior director of edu cation and research for the Office of Professional Programs and asso ciate professor of clinical pharma cy at The Philadelphia College of Pharmacy and Science. He has served as either a fullor part-time consultant pharmacist since 1976 and currently provides consultant pharmacy services to two Philadel phia nursing facilities in conjunc tion with Mediq Healthcare of Newtown Square, PA. Prior to join ing the faculty of The Philadelphia College of Pharmacy and Science in 1985, he was a faculty member at the University of Georgia, where his clinical teaching sites were two nursing facilities in Athens, GA. Erwin has been active in the So ciety for several years and recently was elected to the ASCP Board of Directors as director of region II. Additionally, he has served on the Educational Affairs Council and is chairman of the Editorial Advisory Board of Drug Regimen Review: A Process Guide for Pharmacists. Dr. George F. Archambault (known as the "Father of Consul tant Pharmacy") is former Wash ington editor of Drug Intelligence and Clinical Pharmacy and phar macy liaison officer to the US Sur geon General. He is the recipient of the highest honors of the Ameri can Pharmaceutical Association (Remington Honor Medal) and the American Society of Hospital Phar macists (Harvey Whitney Lecture Award). He is now retired and lives in Rockville, M D . | 2022-01-27T13:24:59.899Z |
239,684,204 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5005/jp-journals-10057-0145",
"MAG": "3196493172",
"PubMedCentral": null
},
"license": null,
"status": "GOLD",
"url": "https://doi.org/10.5005/jp-journals-10057-0145"
} | Ab s t r Ac t Introduction: Assessing the clinical severity of coronavirus disease-2019 (COVID-19) and triaging to appropriate levels of care is certainly one of the key elements in the success of managing COVID-19 patients. During the concluded wave of the pandemic, cases were categorized and cared for with set criteria prescribed by authorities. Other triaging criteria were included in contemporary international guidelines, but this hypothesis was never tested if anyone set is ever better than the other. Materials and methods: This is a case series of 165 deceased patients of COVID-19. All patients were categorized as per clinical disease severity and admitted to the designated care area after confirmation of SARS-CoV-2 infection as decided by the admitting doctors. We collected retrospective data from patient medical records and analyzed for medical history, comorbidity profiles, hematology investigations, organ function tests, computed tomography of the thorax, and point-of-care biomarker test (D-dimer, procalcitonin, NT-proBNP, Trop-T). These data were analyzed to compare the differences between the variables of ward and ICU patients by using XLstat software. Results: In this analysis of deceased patients’ case series, we found that there was no significant difference among the patients admitted to ward and ICU for initial demographic and biomarker variables and risk factors. Diabetes was the most commonly found comorbidity. The mortality rate among the ward and ICU (5.89 vs 6.67%, p value: 0.44) was also similar among both the cohorts. Conclusion: In this case series, we could conclude that both the cohorts were comparable at admission on demographic and laboratory parameter profile. Clinical significance: This analysis led us to the conclusion that our existing “triage criteria” for COVID-19 patients will need appropriate modification before the second wave sets in the region. | 2022-06-02T15:48:13.103Z |
Subsets and Splits
No saved queries yet
Save your SQL queries to embed, download, and access them later. Queries will appear here once saved.