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250,818,077 | {
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"DOI": "10.1088/0256-307X/29/4/048701",
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} | Idea spreading is an important process in science and society. In this work, we study this spreading process in a population consisting of two groups based on a recent model proposed by Bornholdt et al. We consider two types of division in the population: regular and random division. We find some interesting phenomena, for example, the exchange of dominant ideas between the two groups in the cases of regular and the random division, and the appearance of a novel stage in which a few ideas interact strongly to seek a balance. | 2022-07-31T11:08:28.778Z |
143,469,715 | {
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"DOI": "10.1080/09672559.2012.727013",
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} | Abstract This article examines Adorno’s use of the notion of mediation, which at first glance appears to be problematic and aporetic. While the emergence of such a concept marks Adorno’s renewed interest in Hegelian philosophy, and a distancing from Walter Benjamin’s thought, the understanding of mediation should not be reduced to the Hegelian model. This article will argue that Adorno introduces such a concept to explain theory’s necessity and verifiability, as well as the experience of the object. Only by taking these two issues (the mediation between concepts and between subject and object) in their interconnection is it possible to explain the role of mediation in Adorno. I will argue that the idea of ‘constellations’ put forward in the Dialectics furnishes us with a model of mediation that goes beyond its original Hegelian formulation. | 2022-11-09T17:13:13.249Z |
123,710,302 | {
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"DOI": "10.1142/S1793557115500400",
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} | The classical logic was axiomatized algebraically by means of Boolean algebras in 19th century by George Boole. Similar attempts went on 20th century for algebraic axiomatization of non-classical logics, e.g. intuitionistic logics (Brouwer and Heyting algebras), many-valued logics (Łukasiewicz, Chang’s MV-algebras, Post algebras), the logic of quantum mechanics (orthomodular lattices and posets) and fuzzy logics (residuated lattices). In this paper, we are focused in a common generalization of MV-algebras and orthomodular lattices. The resulting algebras, called basic algebras, have surprisingly strong and interesting properties and they can be investigated in their own. The aim of the paper is to get an overview of results reached during the last decade. | 2022-11-29T01:57:55.089Z |
136,192,387 | {
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"DOI": "10.1080/03602559.2016.1233282",
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} | ABSTRACT This article presents a review of several research works on polypropylene/clay nanocomposites. In this study, we investigate the influence of preparation and treatment parameters of polypropylene/clay nanocomposite on the resulting thermomechanical properties. Compared to pure polymers and conventional composites, composites based on nanoclay particles are increasingly developed in industrial and academic fields as they promote an improvement of the starting polymers properties such as high modulus, heat resistance, gas impermeability, and biodegradability. The improvement of these properties depends on different parameters such as the content of clay and the nanoclay/polymer interaction. GRAPHICAL ABSTRACT | 2022-12-14T10:57:21.807Z |
144,206,338 | {
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"DOI": "10.1111/CURA.12021",
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} | Museums today grapple with the reconciliation of traditional models of authority with the expectation to incorporate new voices in cultural interpretation. At the same time, society is increasingly empowered by a social Web that provides collaboration, connectivity, and openness. This paper frames the dialogue of authority and openness around parallel theories within the museum and technology communities, offering Wikipedia as a platform for facilitating new perspectives in collaborative knowledge-sharing between museums and communities. Expanding on the metaphors of the museum as “the Temple and the Forum” and the Web as “the Cathedral and the Bazaar,” this essay argues that issues of democratization, voice, and authority in museums can be addressed through Wikipedia's community, process, and its potential as a model for a new Open Authority in museums. | 2022-12-12T09:38:04.617Z |
9,264,822 | {
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"DOI": "10.3109/08958378.2014.889257",
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} | Abstract Context: Epidemiological studies have shown an association between the incidence of adverse cardiovascular effects and exposure to ambient particulate matter (PM). Diesel exhaust (DE) is a major contributor to ambient PM and gaseous emissions in urban areas. Objective: This was a pilot study designed to evaluate concentration-dependent effects of short-term exposure to whole DE on the cardiovascular system in order to identify a threshold concentration that can elicit biological responses in healthy human volunteers. Materials and methods: Six healthy middle-aged participants with glutathione-S-transferase-Mu 1 (GSTM1) null genotype underwent sequential exposures to 100 µg/m3, 200 µg/m3, and 300 µg/m3 whole DE generated in real time using an idling diesel truck engine. Exposures were separated by 14 d and each was 2 h in duration. Results: We report concentration-dependent effects of exposure to DE, with 100 µg/m3 concentration causing minimal cardiovascular effects, while exposure to 300 µg/m3 DE for 2 h resulted in a borderline significant reduction of baseline brachial artery diameter (3.34 ± 0.27 mm pre- versus 3.23 ± 0.25 mm post-exposure; p = 0.08). Exposure to the highest concentration of DE also resulted in increases of 5 mmHg in diastolic blood pressure as well as a decrease in indices of the frequency domain of heart rate variability (HRV). Discussion and conclusions: These findings demonstrate that acute exposure to relatively high concentrations of DE produces cardiovascular changes in middle-aged GSTM1 null individuals. This study therefore suggests that arterial vasoconstriction and changes in HRV are responses through which traffic-related air pollution increases the risk of adverse cardiovascular outcomes. | 2022-12-18T08:59:39.272Z |
251,592,695 | {
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"DOI": "10.1080/07853890.2022.2089910",
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"license": "CCBY",
"status": "GOLD",
"url": "https://www.tandfonline.com/doi/pdf/10.1080/07853890.2022.2089910?needAccess=true"
} | Abstract The level of stigmatisation among health care providers has increased during the COVID-19 pandemic, and understanding the effect of COVID-19 stigmatisation on job performance has become increasingly important. The study explores the influence of COVID-19 stigmatisation on job performance among frontline health workers via the mediating role of anxiety. Furthermore, the moderating effect of resilience in the association between COVID-19 stigmatisation and anxiety is further examined. Participants were made up of 820 frontline health workers working in the epicentres of the Bono Ahafo, Western, Greater Accra, and Northern regions of Ghana. The hierarchical regression technique was employed in estimating the relationship between the variables. COVID-19 stigmatisation among frontline health workers directly affected anxiety and performance. In addition, the results showed that resilience moderated the relationship between COVID-19 stigmatisation and anxiety. The findings again demonstrated that anxiety partially mediated the association between concern for disclosure and public attitude and negative experience and job performance, whereas personalised stigma was insignificant. The study provides implications for establishing anti-stigma interventions and programs to enhance job performance among health workers. Key messages Many healthcare workers are subject to stigmatisation during the COVID-19 pandemic. The study employs hierarchical regression methods to examine the impacts of COVID-19 stigmatisation on job performance among frontline health workers. The health management team should strengthen interventions to control the stigma experienced by health workers during COVID-19 treatments. | 2022-12-19T13:55:29.875Z |
95,258,582 | {
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"DOI": "10.1039/DT9930000245",
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} | The 1 : 1 reaction of sodium trifluoroacetate with either [MBr2(NCMe)(CO)2(PR3)2](M = Mo or W, PR3= PMe2Ph or PMePh2) or [MBr2(CO)2(PPh3)2](M = Mo or W) formed the mononuclear complexes [MBr(O2CCF3)(CO)2(PR3)2] containing a bidentate carboxylate ligand. Addition of a second equivalent of the carboxylate salt generated [M(O2CCF3)2(CO)2(PR3)2] in which the oxygen-donor ligands adopt one bidentate and one monodentate bonding mode. Single-crystal X-ray diffraction studies of [MoBr(O2CCF3)(CO)2(PPh3)2] confirm a 4 : 3 polytopal form. The treatment of [MBr2(NCMe)(CO)2(PR3)2](M = Mo, PR3= PMePh2; M = W, PR3= PMe2Ph or PMePh2) or [MBr2(CO)2(PPh3)2](M = Mo or W) with a suspension of sodium oxalate in acetone yielded the complexes [{MBr(CO)2(PR3)2}2(µ-C2O4)]. The tungsten species [{WBr(CO)2(PMe2Ph)2}2(µ-C2O4)] crystallises in two forms both of which contain a planar oxalate bridge linking two seven-co-ordinate metal centres, but have different 4 : 3 geometries. The triangular face of the polygon in each of the three structures is occupied by a bromine atom and two oxygens of a carboxylate group, and the quadrilateral face by pairs of carbonyl and phosphine ligands. | 2022-09-12T03:44:16.666Z |
54,575,226 | {
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"DOI": "10.2193/2007-169",
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} | Abstract In the natural resource and wildlife profession, we face difficulties in the production, diffusion, and transfer of rigorously tested science, especially when facing entrenched management paradigms. We present 3 case studies to illustrate the challenges in changing entrenched management paradigms for endangered species. Here we examine specifically what factors helped or hindered the adoption of management practices through the theoretical framework developed for the dissemination of technologies. An examination of 3 case studies suggests that active communication and advocacy of scientific findings, along with simple, visible results, will aid researchers in the acceptance and adoption of their research. Management agencies that increase openness and communication with outside experts, reduce bureaucratic procedures, and localize decision making increase the likelihood that new scientific ideas will be adopted by the agency. We also suggest adaptive resource management as a strategy for endangered species management may foster many of the characteristics that aid in the adoption of scientific ideas into management activities. | 2022-12-26T20:14:50.428Z |
218,800,830 | {
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"DOI": "10.36099/ajahss.2.4.1",
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"url": "https://doi.org/10.36099/ajahss.2.4.1"
} | Given the current coronavirus global crisis, e-services have never been more relevant as they are today. Like many countries and for many years, the UAE government has focused on the rapid adoption of smart government services in the public sector in orderto achieve the highest international standardsin the electronic-based services. The UAE has established its government strategic plan 2021 vision. In light of this vision, the government of Emirate of Sharjah formed a SupremeCommittee for Digital Transformation. This article aims to investigate Sharjah'sgovernment employees' readiness and preparation for the digital transformation.This article provides an assessment of employees’ readiness by examining how employees perceive e-government andthe extent to which they are ready to embark on the digital transition.The theoretical framework is based on Everett Rogers’ diffusion theory (1962). Diffusion of innovation is the process through whichnew technologies, products, or ideasare diffused and adopted in a social system. The paper used a survey of 110 government employees using both quantitative questions and open-ended qualitative questions. The paper found that while a lot of progress has been made, government employees are still ambivalent about the implementation of Sharjah digital transformation. | 2022-01-27T02:22:41.961Z |
38,960,200 | {
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"DOI": "10.1111/j.1365-2265.1994.tb02525.x",
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} | OBJECTIVE Cranial irradiation frequently results In growth hormone (GH) deficiency. Patients with radiation‐induced GH deficiency usually remain responsive to exogenous growth hormone releasing hormone, implying radiation damages the hypothalamus rather than the pituitary. Little is known about the effect of cranial irradiation on the neuroendocrine control of GH secretion. This study was to determine the effect of cranial irradiation on somatostatin tone. | 2022-11-19T15:11:22.011Z |
15,395,917 | {
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"DOI": "10.3389/fnagi.2017.00019",
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"license": "CCBY",
"status": "GOLD",
"url": "https://www.frontiersin.org/articles/10.3389/fnagi.2017.00019/pdf"
} | Xeroderma pigmentosum (XP) is a rare recessive heredity disease caused by DNA repair impairment characterized by photosensitivity and neurologic symptoms in half of the cases. There are eight subtypes of XP: XP-A–XP-G and XP variant. Among eight subtypes, XP complementation group A (XP-A) display the lowest DNA repair ability and the severest cutaneous and neurologic symptoms. While its pathogenesis of skin symptoms have been well-studied, that of neurological symptoms, including sensorineural hearing loss (SNHL) remains unknown. Basic studies have suggested that SNHL may be caused by inner ear damage, including damage to the spiral ganglion neurons and organ of Corti, and that the XP-A is associated with most severe form of SNHL in humans. Here, we report the occurrence of SNHL in Xpa-deficient mice. Xpa-deficient mice and wild-type mice underwent measurements for auditory brainstem response, and the results revealed that Xpa-deficient mice exhibited significantly greater (p < 0.01) ABR thresholds at 4, 8, and 16 kHz than the wild-type mice. Furthermore, the number of spiral ganglion neurons was reduced in Xpa-deficient mice compared with that in wild-type mice, indicating that hearing loss may be related to spiral ganglion neuron deficiency, consistent with the few reports published in human patients with XP. These results provide important insights into the pathogenesis of SNHL in patients with XP-A. | 2022-11-13T17:18:01.118Z |
213,645,242 | {
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"ArXiv": null,
"DOI": "10.3390/app10031125",
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"url": "https://www.mdpi.com/2076-3417/10/3/1125/pdf?version=1581500138"
} | At present, in the mainstream sentiment analysis methods represented by the Support Vector Machine, the vocabulary and the latent semantic information involved in the text are not well considered, and sentiment analysis of text is dependent overly on the statistics of sentiment words. Thus, a Fisher kernel function based on Probabilistic Latent Semantic Analysis is proposed in this paper for sentiment analysis by Support Vector Machine. The Fisher kernel function based on the model is derived from the Probabilistic Latent Semantic Analysis model. By means of this method, latent semantic information involving the probability characteristics can be used as the classification characteristics, along with the improvement of the effect of classification for support vector machine, and the problem of ignoring the latent semantic characteristics in text sentiment analysis can be addressed. The results show that the effect of the method proposed in this paper, compared with the comparison method, is obviously improved. | 2022-12-07T22:51:42.384Z |
237,648,478 | {
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"ArXiv": null,
"DOI": "10.5465/ambpp.2021.11443abstract",
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} | Strategic management scholars are increasingly paying attention to the micro-foundations of firms’ capabilities by examining how the attributes of individuals within firms can shape organizational-... | 2022-12-16T14:18:49.436Z |
234,410,003 | {
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"DOI": "10.35449/jemasi.v16i2.142",
"MAG": "3117491252",
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"license": "CCBYSA",
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"url": "http://ejournal.iba.ac.id/index.php/jemasi/article/download/142/94"
} | This study was conducted to examine and analyze factors affecting student enterpreneurial interest In Beji Depok –West Java. This study uses a quantitative approach and The method of data analysis uses a partial least squares (PLS) model and The sample of this study used was 75 respondents. The results of this research are there is a positive influence of entrepreneurial motivation on entrepreneurial interest. the family environment variable is not significant on entrepreneurial interest. the personality variable has a significant effect on entrepreneurial interest, there is a positive influence of entrepreneurial motivation on entrepreneurial interest. | 2022-12-19T09:25:31.788Z |
114,270,033 | {
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"ArXiv": null,
"DOI": "10.2528/PIERC16121405",
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} | A compact dual-polarization, ultra-wideband quad-ridged horn antenna has been proposed for breast imaging. CST Microwave Studio Simulation has been used to design the horn antenna. The antenna size was reduced, and impedance matching was achieved by a modest change in the dielectric constant of the matching liquid and by the introduction of four semi-elliptical structure at the flared ridges. To test the polarization isolation, many field probes were distributed at different positions in front of the antenna. The probes have been set to measure both vertical and horizontal electric field components at each location. Results show that adding elliptical parts can provide impedance matching over the whole frequency band of the antenna. Measurements show high isolation between the transmitted vertical and horizontal electric fields. Almost 40 dB polarization isolation exists at boresight of the antenna over the entire frequency band. This characteristic is central to polarimetric radar work. Effective gain and ports isolation were obtained. | 2022-12-19T11:57:48.355Z |
255,171,698 | {
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"DOI": "10.1109/IEEM55944.2022.9989970",
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} | Reliability analysis is one of the most important aspect when conduct performance evaluation of reconfigurable manufacturing system (RMS). Due to the characteristic of such system, its failure rate is piecewise defined, which causes complexity of reliability analysis. There are different kinds of reconfigurability characteristics and configuration order is one of the reconfigurability characteristics in such system paradigms. This paper propose a framework to assess reliability performance of manufacturing system with different configuration orders. In the framework, Markov transfer state of Markov chain is applied in presenting configuration order during processing. Then, different reliability assessment methods with different fault management policies are illustrated. | 2022-12-29T18:09:08.226Z |
251,843,904 | {
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"DOI": "10.1159/000526673",
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"PubMedCentral": "9801364"
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"url": "https://www.karger.com/Article/Pdf/526673"
} | Background: Kuwait and countries in the Arabian Gulf region face an alarming prevalence of noncommunicable diseases (NCDs) that strain their health systems and threaten their economies. To quantify a key dimension of the burden, we estimated the risk of hospital utilization in Kuwait associated with diagnoses of the most prevalent NCDs, excluding cancer, using a generalizable approach suitable for cross-country disease burden comparisons and assessments of prevention effectiveness. Methods: The study analyzed responses from a nationally representative sample of 2,165 individuals with self-reported hospital admissions over 12 months and NCD diagnoses from the World Health Survey in Kuwait in 2010. Hospital utilization rates were examined for individuals diagnosed with hypertension, diabetes mellitus, asthma, chronic lung condition, heart disease, and stroke rates and adjusted for demographic and socioeconomic factors. Count regressions were used to estimate the association between individual NCDs while adjusting for other covariates. Results: Using negative binomial regressions, we found that hypertension, the most common NCD in Kuwait, was associated with 75% higher hospital utilization. In addition, heart disease was associated with a 495% increase in hospital utilization rates after adjusting for potential confounders. Many other demographic, socioeconomic, and behavioral characteristics confounded the sizable increase in the risk of hospital admissions associated with NCDs. Conclusions: We estimated the substantial burden on curative services associated with NCDs in Kuwait through a standardized approach to compare hospital utilization rates associated with various NCDs; this approach is generalizable to more than 70 countries that participated in the World Health Survey. | 2023-01-01T06:47:06.558Z |
220,949,141 | {
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} | T H I S STUDY of Deutero-Isaiah presents no new results. Rather, on the basis of the findings of form-criticism, it seeks to draw as consistent a picture as possible of the message of the unknown prophet of the Exilic Age and of the prophet himself. Such an approach has proved in recent decades to be highly stimulating in the interpretation of the Old Testament. The study begins with a brief survey of the present state of Deutero-Isaiah investigation, then goes on with a description and explanation of the major types or genres (Gattungen) found in Isaiah 40—55. Finally, the results are applied in a sketch of the major points of the message of Deutero-Isaiah. | 2022-01-27T20:07:13.254Z |
37,195,465 | {
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"DOI": "10.1139/cjr47b-060",
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} | The individual adsorption capacities of over 500 granules of 6 to 10 mesh activated cocoanut-shell charcoal were determined by weighing each piece separately on a microbalance before and after saturation with carbon tetrachloride vapor. The particle capacities were found to be distributed over a probability curve represented by the equationSmall particles adsorb more carbon tetrachloride than large ones and dense particles more than those of lesser density. | 2022-02-12T07:05:50.806Z |
246,397,790 | {
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"DOI": "10.5902/1679849x9606",
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"url": "https://periodicos.ufsm.br/LA/article/download/9606/5741"
} | O número 21 da Revista Eletrônica Literatura e Autoritarismo, primeiro semestre de 2013, está composto por onze artigos que tratam primordialmente de temas que envolvem questões sobre o conceito de identidade, constituições identitárias e memória, apresentando também outras reflexões acerca das relações entre a literatura e as políticas governamentais, o autoritarismo, a repressão e a censura nas suas mais variadas formas. | 2022-02-04T02:16:00.600Z |
62,176,188 | {
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"DOI": "10.1136/bmj.1.5345.1600",
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} | steroids in blood and urine (D. H. Nelson), of the mode of action of A.C.T.H. (V. DiRaimondo), of primary aldosteronism (E. G. Biglieri), and of adrenal medullary function (A. Goldfien). All contributors have attempted to assess the value of the tests discussed and they have undoubtedly provided a most useful summary of the subject. The reviewer was surprised, however, to find no mention of 1321, the short-lived radioiodine isotope now widely used in thyroid-function tests, and to see that 4-hydroxy-3methoxymandelic acid, the principal metabolite of adrenaline and noradrenaline, is erroneously described as " vanillylmandelic acid (VMA) "-but these are small blemishes. Throughout the book the emphasis is placed on clinical indications and interpretations; technical details are omitted unless they have a vital bearing on the results obtained. The bibliography is selective rather than comprehensive, but most chapters include suggestions for general reading. The book is excellently produced and contains an adequate index. It can be confidently recommended to clinicians who wish to keep abreast of the developments in the diagnosis of endocrine disorders without having to resort to original publications. Research workers also will find in it much that is interesting and informative. J. H. WILKINSON. | 2022-07-10T03:21:07.756Z |
250,749,202 | {
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"DOI": "10.1209/0295-5075/3/3/017",
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} | The (2̄01) cleavage plane of single crystals K0.3MoO3 and Rb0.3MoO3 have been prepared and examined using LEED, AES and angle-resolved UPS techniques. Stability conditions of the materials under the experimental probes in UHV conditions have been determined. LEED shows that the surface periodicity is the same as that of the bulk (2̄01). Photoemission data show that the top of the valence band is 3.2 eV below EF. The conduction band has width and emission properties consistent with the calculated band structure. Surface states in the gap exhibit sharp angular dependence. | 2022-07-31T09:09:12.215Z |
250,537,690 | {
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"DOI": "10.2196/36747",
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} | Background Cardiovascular diseases (CVDs) were accountable for 24% of the total deaths in Cambodia, one of the low- and middle-income countries, where primary health care (PHC) settings generally do not perform well in the early detection, diagnosis, and monitoring of leading risk factors for CVDs, that is, type 2 diabetes (T2D) and hypertension (HT). Integrated care for T2D and HT in the Cambodian PHC system remains limited, with more than two-thirds of the population never having had their blood glucose measured and more than half of the population with T2D having not received treatment, with only few of them achieving recommended treatment targets. With regard to care for T2D and HT in the public health care system, 3 care models are being scaled up, including (1) a hospital-based model, (2) a health center–based model, and (3) a community-based model. These 3 care models are implemented in isolation with relatively little interaction between each other. The question arises as to what extent the 3 care models have performed in providing care to patients with T2D or HT or both in Cambodia. Objective This protocol aims to show how to use primary data from a population-based survey to generate data for the cascades of care to assess the continuum of care for T2D and HT across different care models. Methods We adapt the HIV test-treat-retain cascade of care to assess the continuum of care for patients living with T2D and HT. The cascade-of-care approach outlines the sequential steps in long-term care: testing, diagnosis, linkage with care, retention in care, adherence to treatment, and reaching treatment targets. Five operational districts (ODs) in different provinces will be purposefully selected out of 103 ODs across the country. The population-based survey will follow a multistage stratified random cluster sampling, with expected recruitment of 5280 eligible individuals aged 40 and over as the total sample size. Data collection process will follow the STEPS (STEPwise approach to NCD risk factor surveillance) survey approach, with modification of the sequence of the steps to adapt the data collection to the study context. Data collection involves 3 main steps: (1) structured interviews with questionnaires, (2) anthropometric measurements, and (3) biochemical measurements. Results As of December 2021, the recruitment process was completed, with 5072 eligible individuals participating in the data collection; however, data analysis is pending. Results are expected to be fully available in mid-2022. Conclusions The cascade of care will allow us to identify leakages in the system as well as the unmet need for care. Identifying gaps in the health system is vital to improve efficiency and effectiveness of its performance. This study protocol and its expected results will help implementers and policy makers to assess scale-up and adapt strategies for T2D and HT care in Cambodia. Trial Registration International Standard Randomised Controlled Trials Number (ISRCTN) registry ISRCTN41932064; https://www.isrctn.com/ISRCTN41932064 International Registered Report Identifier (IRRID) DERR1-10.2196/36747 | 2022-11-11T08:16:44.377Z |
226,906,995 | {
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"url": null
} | Objective
To determine the risk factors for moderate and severe postoperative pain in patients undergoing percutaneous nephrolithotomy.
Methods
Eighty-one patients of both sexes, aged 18-70 yr, with body mass index of 19-42 kg/m2 , of American Society of Anesthesiologists physical status Ⅰ or Ⅱ patients, undergoing elective percutaneous nephrolithotomy under general anesthesia, were selected.When moderate and severe postoperative pain developed (visual analog scale score ≥ 4), dezocine 5 mg was intravenously injected with the dosing interval greater than 4 h. According to the occurrence of moderate and severe pain within 24 h after operation, the patients were divided into moderate and severe pain group and non-moderate and severe pain group.The age, sex, American Society of Anesthesiologists physical status, body mass index, preoperative abnormality of creatinine, urinary leukocyte, urinary bacteria, surgical site, severity of hydronephrosis, the number of affected renal calyx, CT value of stones, length of puncture channel, operation time, the number of postoperative drainage tube and residual stones were collected.Multivariate logistic regression analysis was performed to stratify the risk factors for moderate and severe postoperative pain.
Results
A total of 79 patients were included in this study.Among the 79 patients, 47 patients developed moderate or severe pain, and the incidence was 59%.The results of multivariate logistic regression analysis showed that the number of preoperative affected renal calyx>3, CT value of stones >1 000 and postoperative residual stones were independent risk factors for moderate and severe pain after percutaneous nephrolithotomy (P<0.05).
Conclusion
The number of preoperative affected renal calyx>3, CT value of stones >1 000 and postoperative residual stones are independent risk factors for moderate and severe postoperative pain in the patients undergoing percutaneous nephrolithotomy.
Key words:
Pain, postoperative; Risk factors | 2022-12-03T14:23:49.722Z |
252,882,937 | {
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"url": "https://www.mdpi.com/2077-1312/10/10/1475/pdf?version=1666681075"
} | The understanding of the occurrence of extreme waves is crucial to simulate the growth of waves in coastal regions. Laboratory experiments were performed to study the spatial evolution of the statistics of group-focused waves that have a relatively broad-banded spectra propagating from intermediate water depth to shallow regions. Breaking waves with different spectral types, i.e., spectral bandwidths and wave nonlinearities, were generated in a wave flume using the dispersive focusing technique. The non-Gaussian behavior of the considered wave trains was demonstrated by the means of the skewness and kurtosis parameters estimated from a time series and was compared with the second-order theory. The skewness and kurtosis parameters were found to have an increasing trend during the focusing process. During both the downstream wave breaking and defocusing process, the wave train dispersed again and became less steep. As a result, both skewness and kurtosis almost returned to their initial values. This behavior is clearer for narrower wave train spectra. Additionally, the learning algorithm multilayer perceptron (MLP) was used to predict the spatial evolution of kurtosis. The predicted results are in satisfactory agreement with experimental findings. | 2022-12-02T12:16:11.282Z |
80,620,295 | {
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"DOI": "10.3174/ajnr.A2601",
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} | SUMMARY: Panitumumab (Vectibix), is a human monoclonal antibody EGFR antagonist indicated as a single agent for the treatment of metastatic colorectal carcinoma with disease progression on or following fluoropyrimidine, oxaliplatin, and irinotecan chemotherapy regimens. This article will present the mechanism of action as well as the clinical role for this monoclonal antibody. | 2022-12-10T19:11:21.169Z |
85,909,729 | {
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"DOI": "10.1161/hyp.66.suppl_1.p624",
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} |
Objective:
The peptide chemerin is an emerging novel vasoconstrictor which has been implicated in altering vascular function in animal models. CMKLR1 is a known chemerin receptor which functions predominately in immune response. Chemerin has also been proposed as the ligand for orphan receptor GPR1, which our group has recently confirmed. We tested the hypothesis that chemerin was vasoactive in human vessels and identified which receptor mediated this action.
Method and Results:
Immunohistochemistry revealed that chemerin was expressed in endothelial cells and receptors CMKLR1 and GPR1 were expressed in the smooth muscle cells of human vessels. Quantitative PCR analysis of human vessels supported this with CMKLR1 10 fold more abundant than GPR1. C-terminal fragment chemerin149-157 (C9) caused a concentration dependent contraction in isolated endothelium denuded human saphenous vein (hSV) with a pD2=7.4±0.3 (n=4), which was shifted to the right by antagonist CCX832 (100mM), pD2=6.1±0.2 (n=3). Full characterisation of the novel antagonist CCX832 with receptor-transfected cells confirmed it to be selective for the CMKLR1 receptor, and had no effect on GPR1. In β-arrestin recruitment assays, CCX832 was functionally active at the CMKLR1 receptor causing a rightward shift of the C9 response, logKD=-8.2±0.1 (n=3); however no effect was seen at the GPR1 receptor. Radiolabelled competition binding experiments showed that CCX832 competes for binding with [125I]-C9 at the CMKLR1 receptor, pIC50=9.0±0.1 (n=5), however it does not at the GPR1 receptor. In competition binding experiments on human saphenous vein homogenate, CCX832 competes for binding with [125I]-C9, pIC50=8.6±0.4 (n=6). This is in agreement with the in vitro pharmacology data, that chemerin’s vasoactivity is mediated by CMKLR1. Data is expressed as mean±SEM.
Conclusion:
These data support the emerging role of chemerin as an endogenous vasoconstrictor through its receptor CMKLR1. It identifies for the first time the components of the chemerin axis in the human vasculature, and confirms that chemerin causes vasoconstriction of human vessels. This study identifies a novel therapeutic drug target for hypertension in humans.
| 2022-12-13T19:19:43.424Z |
84,894,147 | {
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} | Abstract Invasive plants can cause significant problems in natural and agricultural ecosystems. Although research has already been conducted on the economics of a single‐control option for some invasive weeds, we extended the analysis by developing a dynamic optimisation model that evaluates the net benefits of a range of possible control options simultaneously in order to identify the optimal strategy (mix of control options). This paper focuses on Californian thistle (Cirsium arvense) in pasture in New Zealand. The net benefit is maximised by considering the costs and efficacy of control options, and the monetary value of animal production. Trajectories of shoot density are developed and the optimal strategies are found. Our results suggest that the introduction of a biological control agent (Apion onopordi), in combination with one or more control options, is the optimal strategy when the initial density of the thistle population exceeds 1.0 shoot m‐2. Results show that in the setting of the model excluding MCPA, MCPB and a Sclerotinia sclerotiorum‐based mycoherbicide reduces the net present value (NPV) by less than 2%. | 2022-12-16T03:46:37.144Z |
11,423,954 | {
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"DOI": "10.3390/ijms16010049",
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"url": "https://www.mdpi.com/1422-0067/16/1/49/pdf?version=1419332651"
} | Nitric oxide (NO) is highly unstable and has a half-life of seconds in buffer solutions. It is synthesized by NO-synthase (NOS), which has been found to exist in the following three isoforms: neuro nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS), and endothelial nitric oxide synthase (eNOS). NOS activity is localized in the reproductive tracts of many species, although direct evidence for NOS isoforms in the Fallopian tubes of mice is still lacking. In the present study, we investigated the expression and regulation of NOS isoforms in the mouse and human Fallopian tubes during the estrous and menstrual cycles, respectively. We also measured isoform expression in humans with ectopic pregnancy and in mice treated with lipopolysaccharide (LPS). Our results confirmed the presence of different NOS isoforms in the mouse and human Fallopian tubes during different stages of the estrous and menstrual cycles and showed that iNOS expression increased in the Fallopian tubes of women with ectopic pregnancy and in LPS-treated mice. Elevated iNOS activity might influence ovulation, cilia beats, contractility, and embryo transportation in such a manner as to increase the risk of ectopic pregnancy. This study has provided morphological and molecular evidence that NOS isoforms are present and active in the human and mouse Fallopian tubes and suggests that iNOS might play an important role in both the reproductive cycle and infection-induced ectopic pregnancies. | 2022-12-18T00:31:01.716Z |
129,149,161 | {
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"DOI": "10.1071/WF10063",
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} | The relative influence of the factors acting on burn probability, namely fuel and weather, is not well understood, especially in Europe. We use a digital fire atlas (1975–2008) and apply survival analysis to individual fires (1998–2008) to describe how burn probability changes with fuel age in Portugal. The typical fire return interval and median fire-free interval vary regionally from 23 to 52 and 18 to 47 years. Increase of the hazard of burning with time is generally near-linear, denoting moderate fuel-age dependency, as in some other shrub-dominated Mediterranean environments. Analysis of complete fire intervals resulted in shorter fire return interval and higher fuel-age dependency of burn probability than findings that included censored observations. Increasingly severe weather conditions either expressed through fire size or by extreme fire danger concurrently decreased fuel-age dependency and selected older fuels. The results are discussed from the viewpoints of fire suppression and fuel treatments. | 2022-12-20T16:40:50.371Z |
235,720,901 | {
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"DOI": "10.1093/jacamr/dlaa099",
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"url": "https://academic.oup.com/jacamr/article-pdf/2/4/dlaa099/38269526/dlaa099.pdf"
} | Graphical Abstract Graphical Abstract | 2022-01-27T14:50:26.235Z |
1,252,730 | {
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} | Summary A horse antimouse lymphocyte serum was shown to be immunosuppressive in prolonging the survival of C3H skin allografts on Balb/c mice. Despite the immunosuppressive effect of that preparation, however, mixtures of histoincompatible lymph node cells obtained from treated mice showed: (a) an increased local reactivity in the skin of the X-irradiated hamster; (b) a more rapid clearance from those intradermal injection sites; and (c) a significant, in vitro production of nonspecific lymphocytotoxic substance (s). We conclude that the liberation of cytotoxic substance (s) through mouse cell lysis is responsible, in part, for the increased local reactivity of lymph node cells obtained from immunosuppressed mice. | 2022-01-27T15:02:57.601Z |
225,712,952 | {
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} | In order to increase the activity and selectivity towards to light olefins in the Fischer-Tropsch synthesis, new support for the role of iron (Fe) are presented. Thus, SBA-15 was synthetized and doped with different alkaline metals preserving the structural characteristics of the mesoporous solid. The samples were characterized by X-ray diffraction at low angles, N 2 adsorption, atomic absorption spectroscopy, CO 2 desorption at programmed temperature and isopropanol test. The alkaline metals (Li, K and Cs) introduction into the channels of the solid, generate basic sites of different strength that are not present in the SBA-15 without doping and do not produce significant changes in the structural and textural properties of the SBA-15, only a densification in the walls of the channels is evidenced. According to the alkaline metal used and through CO 2 adsorption and isopropanol decomposition, it was possible to established the order by the total number of sites: Li >> K » Cs, and the force order for both types of sites (weak and intermediate): Li > Cs > K. | 2022-12-13T10:11:57.476Z |
1,754,346 | {
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"url": "https://www.kjim.org/upload/kjim-29-6-20_830-833.pdf"
} | To the Editor,
The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) erlotinib is active in patients with metastatic lung adenocarcinoma carrying mutations in the EGFR gene. Although erlotinib has been found to improve markedly progression-free survival and quality of life, most patients who show an initial response eventually develop disease progression. Possible mechanisms of acquired or secondary resistance to erlotinib include second mutations in the EGFR gene such as T790M, activation of an alternative pathway including Met or HER2 amplification, histological transformation to small cell lung cancer (SCLC) and epithelial to mesenchymal transition [1]. However, acquired resistance due to histological transformation into a large cell neuroendocrine carcinoma (LCNEC) is uncommon. Herein we describe a patient who developed a LCNEC at the time of acquired resistance to erlotinib during treatment for primary lung adenocarcinoma.
A 33-year-old male was admitted to the Department of Neurosurgery because of headache and diplopia. Brain magnetic resonance imaging (MRI) revealed multiple metastatic masses in the left frontal and right temporal lobes and the left cerebellum of the brain. The largest mass in the left frontal lobe measured 3.4 cm and caused midline shifting of the brain (Fig. 1).
Figure 1
Magnetic resonance imaging of multiple metastatic masses in the brain. (A) T2-weighted image of the left frontal lobe mass. (B) T2-weighted image of the right temporal lobe.
A left frontal craniotomy was performed to remove the mass in the left frontal lobe. The specimen was positive for cytokeratin-7 (CK-7), thyroid transcription factor-1 (TTF-1), leukocyte common antigen, CK-20, and vimentin, indicating a well-differentiated adenocarcinoma (Fig. 2). The patient was subsequently referred to the Department of Medical Oncology.
Figure 2
(A) Adenocarcinoma from brain tissue after craniotomy at the time of initial diagnosis (H&E, ×400). (B) Large-cell neuroendocrine carcinoma (LCNEC) from rebiopsied sample (H&E, ×400). (C) LCNEC from rebiopsied sample (chromogranin, ...
Chest computed tomography (CT) showed multiple nodules in both lung parenchyma and enlarged lymph nodes in both mediastinal and right hilar and right supraclavicular areas (Fig. 3). Abdominal CT showed a heterogeneously enhanced mass, measuring 3.6 × 4.1 cm in the lower portion of the left kidney, along with multiple enlarged lymph nodes near the left renal vein and a low density mass 1.4 cm in size near the right kidney. A bone scan showed sacral metastasis.
Figure 3
Chest computed tomography images of paratracheal lymph nodes. (A) Paratracheal lymph node enlarged at the time of initial diagnosis. (B) Disease progression after two cycles of pemetrexed-cisplatin as first-line chemotherapy. (C) Partial response after ...
The patient was diagnosed with metastatic lung adenocarcinoma. Analysis of the EGFR gene showed a deletion in exon 19.
The patient underwent CyberKnife surgery treatment of the left cerebellar hemisphere, right temporal lobe and left precentral gyrus, followed by two cycles of pemetrexed-cisplatin as first-line chemotherapy. However, follow-up CT showed progressive disease (Fig. 3).
Second-line treatment with erlotinib for 2 months showed a partial response in the lung nodules, mediastinal lymph nodes, and kidney masses. Four months after erlotinib was started, the patient experienced pain in the hip and right leg. MRI of the L-spine and sacrum revealed a 3.8 × 7.8 × 4.4 cm lobular mass involving the right sacral body crossing the midline with extraosseous extension into the spinal canal and obliteration of the right side S1 nerve root. The patient was treated with palliative radiotherapy to the sacrum (total, 4,200 cGy in 14 fractions). Erlotinib was continued during palliative radiotherapy. After 10 months of treatment with erlotinib, the right lower paratracheal lymph node increased in size from 1 to 3 cm (Fig. 3).
A rebiopsy of the right paratracheal lymph node using mediastinoscopy showed two different types of cells: adenocarcinoma cells, as shown on initial pathology, and LCNEC cells, comprising 50% of the microscopic field. The LCNEC cells were positive for chromogranin, CK-7, neuron specific enolase, and TTF-1 and negative for CD56a (Fig. 2). The EGFR gene in the second biopsy specimen was not analyzed due to patient refusal. Despite receiving three cycles of etoposide-cisplatin chemotherapy, along with maintenance erlotinib to prevent disease flare up from erlotinib discontinuation, the disease progressed (Fig. 3).
After 1 month observation period, the patient visited our emergency room with fever and dyspnea. Chest CT showed enlarged mediastinal lymph nodes invading the trachea and superior vena cava (SVC), consistent with SVC syndrome. Palliative emergency radiation treatment of the mediastinal mass (3,000 cGy in 10 fractions) was started immediately. Follow-up chest CT showed that several parenchymal nodules in both lungs had increased in size, while others had decreased and the size of the mediastinal lymph nodes had decreased. However, the SVC remained obstructed and salvage chemotherapy with topotecan was started. Topotecan chemotherapy was discontinued after one cycle due to worsening of the patient's general condition and tumor lysis syndrome. After 5 days of intensive care unit care, the patient died.
Acquired or secondary resistance to EGFR TKIs is associated with histological transformation into SCLC and changes in the molecular genetics of lung adenocarcinoma [2]. Therefore, a rebiopsy is warranted when disease progression is observed during treatment with an EGFR TKI. The mechanism of histological transformation remains unclear. A female patient diagnosed initially with adenocarcinoma subsequently developed SCLC upon disease progression, with the SCLC cells harboring an 18 bp deletion in exon 19 of the EGFR gene [3]. An analysis of the molecular genetic and histological features of 37 patients with progressive disease after durable response to EGFR TKI showed the EGFR T790M mutation in 18 patients (49%) and Met amplification and PIK3CA mutations in two patients (5%) each [2]. In five patients (14%), histological transformation to SCLC was confirmed based on expression of neuroendocrine markers, with the original EGFR mutation maintained. One of the five patients with SCLC transformation also had a mutation in PIK3CA, with four showing resistance during treatment with an EGFR TKI.
Two cases of histological transformation to neuroendocrine carcinoma during or after treatment with an EGFR TKI were reported recently [4,5]. For example, one patient with an adenocarcinoma showed transformation to combined SCLC and NSCLC with neuroendocrine morphology after 12 months of gefitinib treatment [4]. The patient showed disease progression after four cycles of pemetrexed-cisplatin combination chemotherapy and erlotinib treatment for 12 months, with an EGFR exon 19 deletion observed in a tissue specimen obtained at the time of progression. Therefore, whether histological transformation reflects acquired resistance to EGFR TKI remains unclear. Another patient showed transformation from an adenocarcinoma to EGFR-positive LCNEC after treatment with an EGFR TKI. Following surgery, this patient received radiation treatment concurrent with combination chemotherapy of vinorelbine and cisplatin for disease progression and adjuvant chemotherapy for stage IIIA lung adenocarcinoma with an EGFR mutation. This patient was treated with gefitinib for 24 months and then changed to erlotinib. Since the rebiopsy was obtained when the patient developed resistance to erlotinib, the time of phenotypic switch to LCNEC could not be determined [5].
The timing of histological transformation may require obtaining biopsy samples when the patient shows resistance to each type of systemic treatment. However, repeated biopsies are difficult in clinical practice.
Our patient presented with a combined tumor, consisting of adenocarcinoma and LCNEC components when he developed resistance to erlotinib. The pathological results were confirmed by the histological features of the tumor and with immunohistochemistry of neuroendocrine markers. Molecular genetic analysis of the rebiopsied tissue was not performed and changes in molecular genetic and epigenetic profiles occurring at the time of transformation into LCNEC were not determined because the patient refused further study.
Differential diagnosis of SCLC and LCNEC is difficult in some cases because they have different morphologies, such as organoid nesting, trabecular, rosette-like, and palisading patterns, with neuroendocrine differentiation confirmed immunohistochemically. LCNEC cells are larger than small resting lymphocytes. Compared with SCLC cells, the nucleoli in LCNEC cells are more prominent and their nuclear-cytoplasmic ratio is lower.
Our findings suggest that, during treatment with the EGFR TKI erlotinib, the adenocarcinoma had partially transformed to LCNEC or was undergoing histological transformation. Initial pathological diagnosis was confirmed since the tissue obtained with craniotomy showed no evidence of the LCNEC component. Moreover, rebiopsy of the paratracheal lymph node showed the tumor had a marked initial response to erlotinib but became enlarged again at the time of resistance to EGFR TKI.
The mechanisms of the LCNEC transformation during treatment with EGFR TKI and the development of acquired resistance require further investigations.
In conclusion, we described a patient with metastatic lung adenocarcinoma who experienced a histological transformation to combined LCNEC and adenocarcinoma of the lung during treatment with erlotinib. | 2022-12-16T15:53:33.870Z |
10,192,541 | {
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"url": "https://academic.oup.com/nar/article-pdf/38/suppl_1/D540/16771140/gkp1026.pdf"
} | The Negatome is a collection of protein and domain pairs that are unlikely to be engaged in direct physical interactions. The database currently contains experimentally supported non-interacting protein pairs derived from two distinct sources: by manual curation of literature and by analyzing protein complexes with known 3D structure. More stringent lists of non-interacting pairs were derived from these two datasets by excluding interactions detected by high-throughput approaches. Additionally, non-interacting protein domains have been derived from the stringent manual and structural data, respectively. The Negatome is much less biased toward functionally dissimilar proteins than the negative data derived by randomly selecting proteins from different cellular locations. It can be used to evaluate protein and domain interactions from new experiments and improve the training of interaction prediction algorithms. The Negatome database is available at http://mips.helmholtz-muenchen.de/proj/ppi/negatome. | 2022-12-20T08:25:08.253Z |
13,599,179 | {
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"DOI": "10.1021/ja501489h",
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"url": "https://recercat.cat//bitstream/2072/305884/1/OA%20Efficient%20and%20Limiting%20Reactions%20in%20Aqueous%20Light-Induced%20Hydrogen%20Evolution%20System%20using%20Molecular%20Catalysts%20and%20Quantum%20Dots.pdf"
} | Hydrogen produced from water and solar energy holds much promise for decreasing the fossil fuel dependence. It has recently been proven that the use of quantum dots as light harvesters in combination with catalysts is a valuable strategy to obtain photogenerated hydrogen. However, the light to hydrogen conversion efficiency of these systems is reported to be lower than 40%. The low conversion efficiency is mainly due to losses occurring at the different interfacial charge-transfer reactions taking place in the multicomponent system during illumination. In this work we have analyzed all the involved reactions in the hydrogen evolution catalysis of a model system composed of CdTe quantum dots, a molecular cobalt catalyst and vitamin C as sacrificial electron donor. The results demonstrate that the electron transfer from the quantum dots to the catalyst occurs fast enough and efficiently (nanosecond time scale), while the back electron transfer and catalysis are much slower (millisecond and microsecond time scales). Further improvements of the photodriven proton reduction should focus on the catalytic rate enhancement, which should be at least in the hundreds of nanoseconds time scale. | 2022-12-23T08:19:11.774Z |
59,068,588 | {
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"DOI": "10.1175/JCLI3941.1",
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} | The influence of the natural multidecadal variability of the Atlantic meridional overturning circulation (MOC) on European climate is investigated using a simulation with the coupled atmosphere–ocean general circulation model ECHAM5/Max Planck Institute Ocean Model (MPI-OM). The results show that Atlantic MOC fluctuations, which go along with changes in the northward heat transport, in turn affect European climate. Additionally, ensemble predictability experiments with ECHAM5/MPI-OM show that the probability density functions of surface air temperatures in the North Atlantic/European region are affected by the multidecadal variability of the large-scale oceanic circulation. Thus, some useful decadal predictability may exist in the Atlantic/European sector. | 2022-12-31T19:21:44.516Z |
188,091,336 | {
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"DOI": "10.1215/00138282-7716207",
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"url": "http://sro.sussex.ac.uk/id/eprint/81577/1/FirstWords%2CLastWords%20accepted.pdf"
} | Abstract:This short piece reads two of Phillis Wheatley's elegies to children to reflect on how they represent the dead as speaking rather than silent. It considers how the deceased's speech invokes different categories of the child, overlaying political and theological ideas about children's vulnerability and potential power. | 2022-09-10T11:21:34.900Z |
6,198,166 | {
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} | Three cannulated, lactating cows were used in a 3 x 3 Latin square design to determine the effect of roasting or NaOH treatment of barley on ruminal fermentation and site and extent of digestion of nutrients. Experimental treatments were rolled barley, roasted (exit temperature, 135 degrees C) and rolled barley, and treated with 4% NaOH and 220 L of H2O/tonne of barley. Diets also consisted of grass silage and soybean meal. Treatment with NaOH reduced concentrations of several AA, starch, and NDF in the barley. Starch digestibility in the rumen was lower for barley that was treated with NaOH but was unaffected for roasted barley. Digestibilities of N and starch in the small intestine were reduced for barley treated with NaOH, but values for rolled and roasted barley were similar. Apparent total tract digestibility of starch was reduced for the NaOH treated barley. Treatment of barley with NaOH tended to have a detrimental effect on feed intake, digestibility, and milk production. Roasting of barley did not appear to affect the site or extent of carbohydrate digestion, but roasting protected N from ruminal degradation. The protective effect on the carbohydrate fraction would be expected to be greater if the grain were cooled prior to rolling so that the protein matrix of the starch granule remained intact. | 2022-12-10T10:40:22.204Z |
22,209,744 | {
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} | Tumor cells of two cases of mammary neoplasms in dog were investigated cytogenetically. An 11-year-old cocker spaniel showed a marked X-chromosome in most metaphases (80%). In a 12-year-old poodle, tumor cells with the following abnormalities were found: trisomy 1, monosomy X and two marker chromosomes. | 2022-12-12T00:53:57.438Z |
53,011,473 | {
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} | The paper investigates the potential energy savings in the context of big shopping centers, thanks to the introduction of innovative technologies able to control the ventilation according the real requirement for comfort and health of indoor spaces. The case study analyses a big shopping center, where the ventilation is realized with a centralized air-conditioning plant, working with fixed air flows. Two solutions are proposed to reduce the energy consumption for ventilation. The first considers the installation of heat recovery exchangers, the second the introduction of a control system able to modulate the air exchange, according to the real requirements. An energetic and economic evaluation is reported. | 2022-12-13T11:49:19.422Z |
27,125,833 | {
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} | The vulnerability of aircraft, if attacked by conventional weapons, depends notably on the possibility to initiate and to propagate a combustion reaction in the multicompartmented kerosene tanks. After a review of the related mechanisms and existing studies, the numerical simulation tool MIRAGE (french acronym for gas flow adaptable and transient reactive modeling) is used extensively to investigate the effects of four parameters: the ignition energy (from 5 to 1000 J), the equivalence ratio in air (from 0.3 to 2.19), the tank pressure (from 1 to 1.8 bar absolute), and its volume (from 0.4 to 2 m3). A detailed kinetic mechanism is considered (207 species, 1592 reactions) to properly represent the chemistry. The maximum pressure after explosion is found to depend mainly on the initial pressure and on the equivalence ratio, but not on the tank volume or the applied energy. A critical value of the energy, corresponding to the limit between ignition and no ignition, is shown depending on the equivalence ratio... | 2022-12-17T22:51:18.793Z |
254,847,098 | {
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"DOI": "10.25236/ijfs.2022.041214",
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"url": "http://francis-press.com/uploads/papers/iaVf0K71mQXDdcOMl6awCezc4Eb8Snk7ubv04jK2.pdf"
} | : With the rise of PPP agreements and the expansion of the scope of public law adjustments, administrative agreements have become a way for governments to achieve administrative acts. At this stage, the scope regulation model of China's administrative agreement is the "general prohibition" model, in order to give full play to the advantages of the administrative agreement, after fully comparing the three regulatory models, we put forward the "general allow, special prohibition" model that we should adopt. At the same time, the legal application of administrative agreements has been clearly sorted out. The institutional characteristics and composition analysis of "preferential rights" such as unilateral cancellation and modification are elaborated, followed by logical proof of its application to civil law norms, and finally the possibility of its inclusion in administrative reconsideration is demonstrated, and a preliminary substantive review plan is proposed. | 2022-12-23T02:14:26.024Z |
3,750,304 | {
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"url": "http://hdl.handle.net/2164/10234"
} | Pelvic organ‐preserving radical cystectomy (POPRC) for women may improve postoperative sexual and urinary functions without compromising the oncological outcome compared with standard radical cystectomy (RC). | 2022-12-31T18:04:33.863Z |
224,431,120 | {
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} | 临床诊断的技能在于医生要仔细询问病史,根据患者提供的任何有价值的蛛丝马迹去提出诊断假设,并通过进一步的体格检查和辅助检查来获得证据,验证和推翻不断生成的诊断假设,最终寻找到疾病的根源,以解除或减轻患者的痛苦。 | 2022-02-08T00:23:51.862Z |
110,017,902 | {
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"DOI": "10.1002/(SICI)1098-2760(19990220)20:4<270::AID-MOP14>3.0.CO;2-0",
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} | Multiwavelength oscillation has been obtained in an erbium-doped fiber laser. A double-pass optical fiber Mach–Zehnder interferometer is employed as a comb filter inside the laser cavity. To reduce the homogeneous linewidth, the erbium-doped optical fiber was immersed in liquid nitrogen. Simultaneous oscillation of ten wavelengths is observed. ©1999 John Wiley & Sons, Inc. Microwave Opt Technol Lett 20: 270–272, 1999. | 2022-02-10T05:32:15.205Z |
53,233,153 | {
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} | Digital television was introduced to the Belgian market in 2005, which is fairly late compared to other European countries. By 2010, in Flanders the 50p penetration threshold of digital television households was surpassed. Considering previous research into the adoption of digital television in Belgium, it can be stated that the “majority segments” have embraced iDTV. However, research suggests that this has not necessarily induced a change in their viewing habits and that interactive applications such as video on demand, time-shifted viewing, voting, email, etc., have remained “underused.” Therefore, the user adoption rate of 50p for iDTV does not automatically imply a 50p use diffusion rate of interactive services. Within the iDTV industry, an important challenge will be to convince the remaining 50p of analog viewers to make the switch to digital television. A review of the literature on the adoption and diffusion processes of technologies shows that these later adopters (laggards and late majority) base their decision on the behavior of peers who have already acquired the technology. As they are the least innovative market segment, they will require some compelling arguments to adopt iDTV. These selling arguments could be related to the added value of interactive services which are currently not being used to their full potential by iDTV subscribers. One of the ideas that is currently explored is personalized television content, recommended to television viewers based on their viewing behavior. This article discusses three important research questions based on quantitative empirical data. Firstly, what is the current state-of-the-art in Flanders regarding the adoption and use diffusion of digital television in Flandersq Secondly, what is the interest in a personalization and recommendation tool for iDTV in Flandersq Thirdly, how would an introduction of this tool affect the adoption and use diffusion of iDTV in Flandersq Based on the results presented in this article, it seems that the implementation of a personalization and recommendation tool might stimulate the adoption as well as the use diffusion of digital TV in Flanders. | 2022-02-11T21:51:14.628Z |
14,553,477 | {
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"url": "http://arxiv.org/pdf/astro-ph/9503079"
} | We discuss a possible delay experienced by protogalaxies with low column density of gas in forming stars over large scales. After the hydrogen has recombined, as the external ionizing UV flux decreases and the metal abundance $Z$ increases, the HI, initially in the warm phase ($T\simgt 5000$ K), makes a transition to the cool phase ($T\simlt 100$ K). The minimum abundance $Z_{min}$ for which this phase transition takes place in a small fraction of the Hubble time decreases rapidly with increasing gas column density. Therefore in the ``anemic'' disk galaxies, where $N_{HI}$ is up to ten times smaller than for normal large spirals, the onset of the cool HI phase is delayed. The onset of gravitational instability is also delayed, since these objects are more likely to be gravitationally stable in the warm phase than progenitors of today's large spiral galaxies. The first substantial burst of star formation may occur only as late as at redshifts $z \sim 0.5$ and give a temporary high peak luminosity, which may be related to the ``faint blue objects". Galaxy disks of lower column density tend to have lower escape velocities and a starburst/galactic fountain instability which decreases the gas content of the inner disk drastically. | 2022-10-27T06:44:57.744Z |
222,163,466 | {
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"DOI": "10.3390/genes11101161",
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"url": "https://www.mdpi.com/2073-4425/11/10/1161/pdf?version=1602826887"
} | Since their domestication, Brassica oilseed species have undergone progressive transformation allied with the development of breeding and molecular technologies. The canola (Brassica napus) crop has rapidly expanded globally in the last 30 years with intensive innovations in canola varieties, providing for a wider range of markets apart from the food industry. The breeding efforts of B. napus, the main source of canola oil and canola meal, have been mainly focused on improving seed yield, oil quality, and meal quality along with disease resistance, abiotic stress tolerance, and herbicide resistance. The revolution in genetics and gene technologies, including genetic mapping, molecular markers, genomic tools, and gene technology, especially gene editing tools, has allowed an understanding of the complex genetic makeup and gene functions in the major bioprocesses of the Brassicales, especially Brassica oil crops. Here, we provide an overview on the contributions of these technologies in improving the major traits of B. napus and discuss their potential use to accomplish new improvement targets. | 2022-12-03T20:59:39.149Z |
96,618,818 | {
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"DOI": "10.1039/B006693L",
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} | Based on a Heck reaction protocol, trivinylogs of Crystal Violet have been prepared and show strong absorptions in the near-infrared region. | 2022-12-13T14:26:03.758Z |
30,288,178 | {
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"DOI": "10.1209/EPL/I1996-00296-0",
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} | Recently, isotope shifts of 72,74−96Kr and 77−100Sr have been measured at the ISOLDE/CERN mass separator facility by collinear laser spectroscopy. The deduced changes in mean-square charge radii reveal sharp transitions in nuclear shape from spherical near the magic neutron number N = 50 towards strongly deformed for both the neutron-deficient and neutron-rich isotopes far from stability. The mean-square charge radii of the neutron-deficient isotopes exhibit a sign change of the odd-even staggering (OES), i.e. below the neutron number N = 46 the radius is systematically larger for the odd-N nuclei than for their even-N neighbours. This is in contrast to the situation of normal OES which is observed for the heavier isotopes. The inversion of the OES is interpreted as an effect of polarization, triggered by the addition of an unpaired neutron and driving the soft even-even core into stable strong deformation. | 2022-11-25T17:31:04.121Z |
122,636,234 | {
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"DOI": "10.1103/PHYSREVB.56.2306",
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} | pumped ruby 1 have shown that the geometry of the crystal and the active zone plays a crucial role in the development of the avalanche. A bulk single crystal with parallel end faces was found to act as a phonon cavity, so that the phonons produced by the avalanche repetitively pass through the active zone and the avalanche is amplified further upon each passage. In the present study, we investigate the phonon avalanche in the restrictive geometry of a thin fiber, which is distinct from a bulk crystal in that the phonons reflecting from the outer wall return to the active zone from many more directions and without significant delay. The magnetic-field split E( 2 E) doublet of Cr 31 again serves as active medium, its upper level E 1 being populated over the larger part of the fiber by selective optical excitation. Stimulated emission of phonons then results from resonant one-phonon processes induced by the spin-lattice interaction to the lower E( 2 E) | 2022-12-16T21:12:13.410Z |
24,121,190 | {
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"DOI": "10.1073/PNAS.77.10.6042",
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} | Mutations arising in dysgenic hybrids of Drosophila melanogaster were collected in the zeste-white region of the X chromosome. A preponderance of the mutations affected the zw1 locus; many of these were asociated with structural abnormalities including inversions, deficiencies, and insertions in the 3A3-4 region of the polytene chromosome map. The extreme sensitivity of the zw1 locus to the mutator activity of dysgenic hybrids contrasted with the apparent insensitivity of the zw2 locus. Other loci in the zeste-white region were weakly sensitive to the mutator activity. Insertions of two and six bands were seen between bands 3A4 and 3A6 in the chromosomes of one of the zw1 mutant stocks examined. Another insertion was detected at position 2F4-5 in a different stock. Many of the mutant chromosome were evidently unstable, as judged by secondary breakage in other parts of the X chromosome. The cytogenetic data are consistent with the idea that mutations arising in dysgenic hybrids are caused by transposable elements which insert preferentially at certain sites on the chromosomes. | 2022-12-18T19:01:00.252Z |
85,545,694 | {
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"DOI": "10.1002/ajmg.a.61134",
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"url": "https://europepmc.org/articles/pmc6488410?pdf=render"
} | Phacomatosis pigmentovascularis (PPV) comprises a family of rare conditions that feature vascular abnormalities and melanocytic lesions that can be solely cutaneous or multisystem in nature. Recently published work has demonstrated that both vascular and melanocytic abnormalities in PPV of the cesioflammea and cesiomarmorata subtypes can result from identical somatic mosaic activating mutations in the genes GNAQ and GNA11. Here, we present three new cases of PPV with features of the cesioflammea and/or cesiomarmorata subtypes and mosaic mutations in GNAQ or GNA11. To better understand the risk of potentially occult complications faced by such patients we additionally reviewed 176 cases published in the literature. We report the frequency of clinical findings, their patterns of co‐occurrence as well as published recommendations for surveillance after diagnosis. Features assessed include: capillary malformation; dermal and ocular melanocytosis; glaucoma; limb asymmetry; venous malformations; and central nervous system (CNS) anomalies, such as ventriculomegaly and calcifications. We found that ocular findings are common in patients with phacomatosis cesioflammea and cesiomarmorata. Facial vascular involvement correlates with a higher risk of seizures (p = .0066). Our genetic results confirm the role of mosaic somatic mutations in GNAQ and GNA11 in phacomatosis cesioflammea and cesiomarmorata. Their clinical and molecular findings place these conditions on a clinical spectrum encompassing other GNAQ and GNA11 related disorders and inform recommendations for their management. | 2022-12-18T17:19:52.591Z |
95,552,565 | {
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"DOI": "10.1046/j.1365-2389.2001.00394.x",
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} | The test for the degree of phosphorus (P) saturation (DPS) of soils is used in northwest Europe to estimate the potential of P loss from soil to water. It expresses the historic sorption of P by soil as a percentage of the soil's P sorption capacity (PSC), which is taken to be α (Alox + Feox), where Alox and Feox are the amounts of aluminium and iron extracted by a single extraction of oxalate. All quantities are measured as mmol kg soil−1, and a value of 0.5 is commonly used for the scaling factor α in this equation. Historic or previously sorbed P is taken to be the quantity of P extracted by oxalate (Pox) so that DPS = Pox/PSC. | 2022-12-21T05:59:23.068Z |
239,683,725 | {
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"DOI": "10.20372/AJBS.2021.6.1.255",
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} | This study was undertaken to determine the extent to which instructional objectives were measured by departmentalized teacher made final examinations. Teacher-made examinations at Woldia College of Teacher Education weight up to forty (40%) percentage of a student’s grade point average almost for all semester courses. The study used the descriptive research design. The total number of sample test papers (18 in number) taken comprise 50% of the total final departmental examinations given in the semester. As source of data both interview and open-ended type of questionnaire that was developed to analysis exam paper were used. Six department heads were selected and interviewed purposefully. For the analysis purpose, this study mainly used qualitative analysis; simple descriptive statistical analysis that is simple percentage was also used. The major findings of the study were: 1. all sampled final examination papers didn’t measure, synthesis and evaluation and practical skills capabilities of trainees.2. The content validity of sampled examination papers seemed to be low because all instructors didn’t use table of specifications while preparing their final exams. Questions designed for final examinations were not inclusive in terms of assessing from simple to higher order learning outcomes. Based on the above findings, the researcher recommended the following points. Teachers must undergo periodic seminar-workshop on measurement and evaluation with emphasis on test construction, item analysis, test validation and administration to enhance the teachers' capability of producing valid and reliable test. | 2022-02-07T20:19:43.011Z |
70,954,454 | {
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"DOI": "10.18203/2320-6012.ijrms20150627",
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"url": "https://www.msjonline.org/index.php/ijrms/article/download/1719/1631"
} | Background: Low back pain is a common musculoskeletal symptom caused by a variety of disorders that affect the lumbar spine. The most frustrating aspect in the treatment of low back pain is that there is “no magic bullets”. The objective of the study was to compare the efficacy and safety of flupirtine versus piroxicam in patients with back pain. Methods: This was prospective, open labeled, randomized, comparative clinical study conducted by the Departments Orthopedics and Pharmacology, BMC&H, Chitradurga. Study was conducted on 60 patients of either sex, aged above 18 years with low back pain. Assessments were done for Finger-to-Floor Distance (FFD), lumbar pain, Lasegue’s sign, tenderness of vertebral muscles, pain & sensory disturbance in lower limbs and response to therapy for efficacy. Parametric data was analyzed by t-test and proportions were compared using Chi-square test. Results: 74 patients were randomized to 2 groups of 37 each. Group I patients received flupirtine maleate 100 mg twice daily and Group II patients received piroxicam 20 mg twice daily for 14 days. 30 patients in each group completed the study and were analysed. On intergroup comparison, there was no statistical difference (p>0.05) in the efficacy parameters of finger-to-floor distance (FFD), lumbar pain, Lasegue’s sign, tenderness of vertebral muscles, sensory disturbance in lower limbs, VAS scores & global assessment of response to therapy. 13.3% in flupirtine group and 16.6% in piroxicam group reported adverse events. Conclusions: Both flupiritine and piroxicam were equally effective but flupirtine was better tolerated than piroxicam. | 2022-09-12T11:33:44.246Z |
233,620,208 | {
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"DOI": "10.1080/09546553.2021.1877673",
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"url": "https://www.tandfonline.com/doi/pdf/10.1080/09546553.2021.1877673?needAccess=true"
} | This article examines the impact of the 15th March 2019 far-right terrorist attack against Muslims in Christchurch, New Zealand on public opinion toward Muslims. It also examines whether the impact... | 2022-09-30T00:42:23.053Z |
253,139,689 | {
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"DOI": "10.55232/2027005",
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} | SEM RESUMO | 2022-10-27T16:45:00.994Z |
52,196,713 | {
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"DOI": "10.21037/atm.2018.05.29",
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"url": "https://atm.amegroups.com/article/viewFile/19688/pdf"
} | Coronary artery disease (CAD), including stable ischemic heart disease (SIHD) and acute coronary syndrome (ACS), remains the leading cause of death in the US and one of the primary modalities used in the treatment of CAD is percutaneous coronary intervention (PCI). Despite the potential benefits of PCI in high risk CAD patients, the risk of hemorrhage presents a dilemma in the treatment of patients with hemophilia A and B. In an attempt to provide guidance on the management of SIHD and ACS in patients with hemophilia, we present the case of a patient with moderate hemophilia B and ACS who subsequently underwent PCI followed by a review of the associated literature. | 2022-10-24T15:58:50.149Z |
86,693,900 | {
"externalids": {
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"DOI": "10.4055/JKOA.2019.54.1.30",
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} | “This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.” The Journal of the Korean Orthopaedic Association Volume 54 Number 1 2019 Received November 14, 2017 Revised January 3, 2018 Accepted February 23, 2018 Correspondence to: Eui-Sung Choi, M.D. Department of Orthopaedic Surgery, Chungbuk National University Hospital, 776 1sunhwan-ro, Seowon-gu, Cheongju 28644, Korea TEL: +82-43-269-6077 FAX: +82-43-274-8719 E-mail: [email protected] ORCID: https://orcid.org/0000-0003-4978-3256 감염성 슬관절염의 관절경적 치료 이후 | 2022-12-09T23:33:18.172Z |
41,448,891 | {
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"DOI": "10.1109/PGEC.1967.264669",
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} | A mathematical model is developed for diagnosing system failures when symptoms are observable. Optimal policies for searching malfunctions yielding minimum expected diagnostic cost are developed, based on the probabilities of various malfunctions conditioned on the set of observable symptoms, the detection probability of each malfunction, and its associated testing cost. The necessary and sufficient conditions satisfied by such policies are derived. The model can be implemented easily on a computer, reducing costs of diagnosis and training diagnosticians. | 2022-12-19T22:54:19.711Z |
237,970,331 | {
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"DOI": "10.37421/2168-9768.2021.10.256",
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} | Sugarcane is one of the most important commercial crops cultivated mostly on the large scale basis all over the world from arid to semi-arid climate condition like Ethiopia. Wonji shoa sugarcane plantation was the first large scale irrigation in Ethiopia. But sugarcane crop is the most water intensive crop that requires critical determination of its evapotranspiration. Determination of crop evapotranspiration is more accurate through experiment but experiment was not mostly undertaken due to high cost, lack of instruments and laboratory facilities, and time it required. But to overcome those problems, some models were developed as an option in determining the crop evapotranspiration. In line with this, the current study focused on the performance evaluation of sugarcane evapotranspiration determined by different models as compared to the lysimeter experiment under study area. The main objective of this study was to analysis the variation of sugarcane evapotranspiration measured from the lysimeter experiment and that determined using different models under the current study climatic condition. In the current study, Blaney-Criddle, Drooger and Allen, Hargreaves, Irmak, Tabari and Thornthwaite were selected. The selected models were required only few climatic parameters. After reference evapotranspiration was determined by each selected models, the sugarcane evapotranspiration was determined by multiplying those reference evapotranspiration by crop coefficient recommended by FAO-56. The performances of those models were evaluated using the most commonly used statistical indices. Those statistical indices used were RMSE, MBE, t-test, R2 and IA. After all the data computed by each selected models the analysed, Blaney-Criddle model was the best model in determining the sugarcane evapotranspiration as compared to the lysimeter experiment followed by Irmak models. Therefore, from the current findings, it can be concluded that Blaney- Criddle model can be used to determine sugarcane evapotranspiration under current study climatic condition. | 2022-02-07T20:39:13.482Z |
194,484,151 | {
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"DOI": "10.36311/1983-2192.2016.v0n17.5977",
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"status": "GOLD",
"url": "http://revistas.marilia.unesp.br/index.php/levs/article/view/5977/4015"
} | Resumo: O artigo objetiva analisar como a violencia policial e o racismo estampam as paginas do romance Bandeira negra, amor. O enredo, que tem como palco o morro do Borel, relata o assassinato de tres adolescentes negros, vistos pela ultima vez entrando em uma viatura da Policia Militar sobre quem recai a autoria da tripla execucao, cujos corpos apresentam sinas de tortura. Entre as acusacoes feitas pelos moradores do bairro a corporacao e a defesa feita pela instituicao, o leitor acessara a historia amorosa entre o advogado das familias das vitimas, o negro Fred e a relacoes publicas da PM, a major Beatriz, que e branca. A obra nos possibilita observar que o tratamento dado pelos aparelhos repressivos as populacoes carentes e negras, reservado as devidas proporcoes, se mantem o mesmo desde as ultimas decadas da escravidao no Brasil Oitocentista. Palavras-chave: Violencia, Literatura, Policia Militar, Preconceito racial, Pobreza Abstract: The article analyzes how the police violence and the racism represent the pages from the romance “Bandeira negra, amor”. The plot happens in the hill of the Borel and describe the murder of three black teenagers, who was seen entering in a Military Police car that is guilty by the murder and shows signs of torture. Between the accusations did by the neighborhood residentes for the corporation and the apology did by the institution, the reader will access the love story between the lawyer of the victims families, the black man Fred and the public relations of the Military Police, the major Beatriz, who is white. The book shows that the treatment given by the repressive powers to the needy and black population remains the same since the last slavery decades in Brazil of the nineteenth century . Keywords: Violence, Literature, Military Police, Racial Prejudice, Poverty | 2022-02-08T08:14:59.660Z |
236,222,372 | {
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"DOI": "10.14505//JEMT.V12.3(51).25",
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} | In the contemporary conditions of tourism activity, tourism enterprises pay special attention to the quality of tourism production, but the dynamic development of living standards, computerized society, new computer technologies, globalization, and others, where tourism requirements and motives may change. The quality of tourism production has a different concept from that of other economic activities. Quality service in the tourism sector means meeting the requirements of the guest - tourist. In the modern conditions of tourism activity, tourism companies pay special attention and care to the quality of tourism production, but here lies the key to the success of any tourism entity, a constant effort to compete in the increasingly fierce tourism market. The need to have the highest quality tourism production forces tourism enterprises to change the managerial concept and use new techniques, putting at the center of their activities the quality of tourism production and service. The purpose of this paper is to study the impact of education on the quality of tourism products, special focus on their meaning, to formulate better strategies in quality improvement as a key element in tourism development, evaluation of tourism products and resources, and in the first place the cultural and historical ones that each particular region has at its disposal as a whole with its own tourist offer. Looking at the different geographical regions we conclude that they have their own peculiarities and different levels of tradition and level of approach to the organization of the tourism branch. But the country can on a strong foundation build the advantages and the identity of the tourism product in high quality forms and content, a product which will be competitive and complementary to the offer of the respective countries. | 2022-01-27T15:53:01.723Z |
250,830,910 | {
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"DOI": "10.1070/QE2005v035n03ABEH002834",
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} | The characteristics of a cw chemical HF laser mechanically Q-switched at a frequency of up to 1000 Hz are studied. It is shown that the peak power of laser pulses increases by a factor of at least five for modulation frequencies from 17 to 250 Hz. The mean output power in the repetitively pulsed mode is appreciably lower than that in the cw lasing mode, but, as the modulation frequency increases (within the same frequency range), the mean power rises more rapidly than the peak power does. The possible factors causing the revealed discrepancies between the experimental and calculated laser characteristics are considered. | 2022-07-31T07:52:55.001Z |
18,771,132 | {
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"DOI": "10.1109/ICC.2010.5502570",
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} | In this paper, we propose a new soft-input soft-output (SISO) multi-input multi-output (MIMO) detection technique, called an improved SISO M-algorithm (ISS-MA). We modify the conventional M-algorithm to improve the performance-complexity trade-off of the SISO symbol detector. Towards this end, an improved path metric is proposed, which accounts for the information on undecided symbols at a particular path visited. The inclusion of this information is enabled through a bias term which is added to the conventional path metric in order to reflect the contributions of the undecided symbols. We derive the bias term using soft unconstrained linear estimates of undecided symbols. As a result, the ISS-MA that picks up the best M candidates based on this modified path metric exhibits improved performance/complexity trade-off compared to the existing SISO detectors. According to extensive simulations performed over i.i.d. Rayleigh fading channels, the proposed SISO detector yields significantly lower complexity than other symbol detectors while maintaining strong performance especially in high dimensional systems. | 2022-09-13T01:56:08.965Z |
24,207,920 | {
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} | STUDY OBJECTIVE
To evaluate the impact on morbidity and mortality of pulmonary contusion in multiple-trauma patients with severe head trauma.
DESIGN
Matched-paired, case-control study
SETTING
ICU at a tertiary university hospital.
PATIENTS
During a 3-year period, 313 consecutive multiple-trauma patients with severe head trauma (Glasgow coma scale [GCS], </= 8) who were admitted to the ICU.
INTERVENTIONS
Case-control matching criteria were as follows: (1) age difference within 5 years; (2) sex; (3) GCS in two categories; (4) similar pattern of injury; and (5) simplified acute physiology score II in five categories. A pulmonary contusion, defined by the clinical context and the result of a chest CT scan, was diagnosed in 90 patients. Analysis was performed on 90 pairs who were matched with 100% success.
RESULTS
Ninety patients (29%) presented a diagnosis of pulmonary contusion. The presence of pulmonary contusion had an impact on the PaO(2)/fraction of inspired oxygen (FIO(2)) ratio, which was significantly reduced in patients with a pulmonary contusion. The ICU stay, the occurrence of complications such as nosocomial pneumonia or ARDS, the Glasgow outcome scale, and the mortality rate did not significantly differ between case patients and control subjects. Mortality also was not affected when patients were stratified according to the severity of the PaO(2)/FIO(2) ratio.
CONCLUSION
In the study patients, pulmonary contusion alters gas exchange but does not appear to increase the morbidity and mortality of multiple-trauma patients with head trauma. A sample-size effect may limit the interpretation of the study. | 2022-09-15T00:10:56.599Z |
218,556,455 | {
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"DOI": "10.1021/acs.langmuir.0c00668",
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} | Recently it was reported that the interface mobility of bubbles and emulsion droplets can have a dramatic effect not only on the characteristic coalescence times but also on the way that bubbles and droplets bounce back after collision (Vakarelski, I. U.; Yang, F.; Tian, Y. S.; Li, E. Q.; Chan D. Y. C.; Thoroddsen, S. T. Sci. Adv.2019, 5, eaaw4292). Experiments with free-rising bubbles in a pure perfluorocarbon liquid showed that collisions involving mobile interfaces result in a stronger series of rebounds before the eventual rapid coalescence. Here we examine this effect for the case of pure water. We compare the bounce of millimeter-sized free-rising bubbles from a pure water–air interface with the bounce from a water–air interface on which a Langmuir monolayer of arachidic acid molecules has been deposited. The Langmuir monolayer surface concentration is kept low enough not to affect the water surface tension but high enough to fully immobilize the interface due to Marangoni stress effects. Bubbles were found to bounce much stronger (up to a factor of 1.8 increase in the rebounding distance) from the clean water interface compared to the water interface with the Langmuir monolayer. These experiments confirm that mobile surfaces enhance bouncing and at the same time demonstrate that the pure water–air interfaces behave as mobile fluid interfaces in our system. A complementary finding in our study is that the ethanol–air interface behaves as a robust mobile liquid interface. The experimental findings are supported by numerical simulations of the bubble bouncing from both mobile and immobile fluid interfaces. | 2022-09-23T00:42:20.872Z |
4,463,632 | {
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} | Picolinic acid (PA) was measured by high pressure liquid chromatography in human milk and other fluids and tissues. Skimmed human milk, intestinal homogenates from human infants and rats, and human and rat pancreatic juice were ultrafiltered and analyzed by high pressure liquid chromatography using an anion-exchange column. Identity of sample components was verified by comparing retention times with those of pure nicotinic acid and PA. The detection limit for PA was 2.5 microM. Human milk contained less than 3.7 microM PA. PA was undetectable in human infant or rat intestine or in human or rat pancreatic juice. The extremely low concentration of PA in milk and its apparent absence in pancreatic juice and intestine provide additional evidence that PA is not the low molecular weight zinc binding ligand of human milk and that it does not have an important physiological role in intestinal zinc absorption. | 2022-12-15T16:19:45.506Z |
119,350,931 | {
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} | We review our recent progress on the study of new nonlinear mechanisms of pulse shaping in passively mode-locked fiber lasers. These include a mode-locking regime featuring pulses with a triangular distribution of the intensity, and spectral compression arising from nonlinear pulse propagation. We also report on our recent experimental studies unveiling new types of vector solitons with processing states of polarization for multi-pulse and tightly bound-state soliton (soliton molecule) operations in a carbon nanotube (CNT) mode-locked fiber laser with anomalous dispersion cavity. | 2022-12-30T00:23:45.180Z |
147,291,697 | {
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"DOI": "10.2466/PR0.1986.58.3.957",
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} | This brief paper serves further to alert users of MMPI self-scoring templates to scoring changes with the 1983 revised templates. | 2022-02-09T05:29:55.695Z |
108,567,496 | {
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"DOI": "10.4296/CWRJ1101069",
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} | Many fens occur in the low arctic of Canada, relying on rainfall and lateral inflow to maintain saturated conditions throughout the thawed season. A study in central Keewatin demonstrates that such wetlands discharge most of the snow meltwater as surface runoff during spring when the ground is frozen. In summer, evaporation and wetland outflow are maintained by rainfall and lateral inflow. Three sources of inflow are recognized; lakes, streams and late-lying snowbanks. The fens of the low arctic can be distinguished clearly in aerial photographs. This offers an easy method of mapping wetlands in the Canadian north. | 2022-02-10T06:57:23Z |
196,773,722 | {
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"DOI": "10.1002/CHIN.201436046",
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} | A protocol for reduction of C-C double and triple bonds is developed, which relies on the in situ generation of diimide from hydrazine hydrate by oxidation with oxygen. | 2022-07-02T14:43:31.959Z |
110,449,715 | {
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} | Abstract The thixoforming process has been applied to forming of a joint node for the aluminum frame of a low speed electric vehicle. A joint node should connect three aluminum extruded chassis showing different profiles. The MHS(magneto-hydrodynamic stirring) A357 billet was selected because homogeneous globular grains are necessary as the billet materials for thixoforming. A careful design of joint node has been performed by the considerations of structural demands and the simulation results for the thixoforming process using the MAGMAsoft. Optimum heating temperature for the A357 billet was between 580 and 585℃ corresponding to the semi-solid temperatures showing 20-30% of liquid fraction. An injection speed of around 100mm/s and preheating of die at temperatures of 200℃ were also necessary conditions to obtain reasonable thixoformed parts. Key Words : Joint Node, Aluminum Frame, Electric Vehicle, Thixoforming, A357, Simulation, Microstructure 1. 서 론 | 2022-08-20T10:49:36.264Z |
87,426,666 | {
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"DOI": "10.1094/PD-78-1202",
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} | Pearl millet (Pennisetum glaucum) inbreds Tifs 383, 700481-21-8, and ICMP 501 were evaluated for partial rust resistance in comparison to susceptible inbreds Tift 23 DB. In field trials, area under the disease progress curves of the three inbreds were less than that of Tift 23 DB when disease pressure nerve. Uredinium dimensions on seedlings 10 days after inoculation were smaller for the three inbreds than for Tift 23 DB. Seedlings exhibited susceptible infection types when inoculated with four single-uredinium isolates except for a moderately resistant infection type 2 when ICMP 501 was inoculated with isolate PS89-775 | 2022-09-14T00:41:23.266Z |
100,451,248 | {
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} | Hydrochlorothiazide (HCT) is a diuretic drug with poor solubility and permeability. Physicochemical properties of HCT have been modified by cocrystallization with piperazine (PPZ), tetramethylpyrazine (TMPZ), picolinamide (PCM), isoniazid (INZ), malonamide (MAM), and isonicotinic acid (INIC) using mechanochemical grinding (liquid assisted and neat). The solids obtained were characterized by single crystal X-ray diffraction (SCXRD), powder X-ray diffraction, Fourier transform infrared spectroscopy, and differential scanning calorimetry and subjected to solubility and membrane permeability studies. SCXRD showed that the N-H...O sulfonamide catemer synthons found in the stable polymorph of pure HCT have been replaced by drug-coformer heterosynthons in the cocrystals. HCT-PPZ and HCT-PCM cocrystals showed improvement in solubility and membrane permeability/diffusion compared to the parent active pharmaceutical ingredient. The improved solubility and diffusion rates are due to the drug-coformer interactions in the new solid forms. A structure-property relationship is examined to evaluate the solubility and diffusion rates of the new solid forms. The cocrystal with INIC, which could not be prepared previously by conventional methods, was obtained by prolonged grinding for 6 days. | 2022-12-11T23:40:54.938Z |
247,443,773 | {
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"DOI": "10.6914/tpss.030506",
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"url": "http://www.ssci.cc/index.php/tpss/article/download/35/31"
} | With the innovation and development of assisted reproductive technology, it is possible for same-sex partners to have their children. More and more same-sex partners choose to have their children through assisted reproductive technology. However, China’s legislation on assisted reproductive technology is not perfect, and the reproductive rights of same-sex partners cannot be guaranteed. This paper selects the related issues of lesbian partners with assisted reproductive technology to have children, through literature research, case analysis, comparative research and other methods, based on the legitimacy of the reproductive rights of lesbian partners, to explore the feasibility of parent-child relationship legal identification of lesbian partners. In order to protect the interests of lesbian partners and their children born through human assisted reproductive technology, the corresponding legal recognition model of parent-child relationship should be constructed. | 2022-12-16T15:24:46.147Z |
206,261,019 | {
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"DOI": "10.1103/PHYSREVLETT.110.256101",
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} | The mobility of molecules on a solid surface plays a key role in diverse phenomena such as friction and self-assembly and in surface-based technologies like heterogeneous catalysis and molecular targeting. To understand and control these surface processes, a universally applicable model of surface transport at solid-liquid interfaces is needed. However, unlike diffusion at a solid-gas interface, little is known about the mechanisms of diffusion at a solid-liquid interface. Using single-molecule tracking at a solid-liquid interface, we found that a diverse set of molecules underwent intermittent random walks with non-Gaussian displacements. This contrasts with the normal random walk and Gaussian statistics that are commonly assumed for molecular surface diffusion. The molecules became temporarily immobilized for random waiting times between surface displacements produced by excursions through the bulk fluid. A common power-law distribution of waiting times indicated a spectrum of binding energies. We propose that intermittent hopping is universal to molecular surface diffusion at a solid-liquid interface. | 2022-12-20T20:14:54.875Z |
93,189,769 | {
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"DOI": "10.1021/CM304029S",
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} | In this research, high resolution transmission electron microscopy (HRTEM) and high angle annular dark field–scanning transmission electron microscopy (HAADF-STEM) studies of ceria(IV) oxide CeO2 nanocrystals (NCs) synthesized by a hydrothermal/two phase process were conducted. The synthesis route affords the possibility of controlling the shape of the CeO2 NCs by changing the oleic acid/cerium ([OLA]/[Ce3+]) ratio. At a relatively low [OLA]/[Ce3+] ratio of 4, a polyhedral NC morphology was obtained with {111} and {200} termination facets. Increasing the [OLA]/[Ce3+] ratio to 8, while maintaining a constant reaction time and temperature during the synthesis, truncated cube-like CeO2 NCs with {200}, {220}, and {111} termination facets was generated. These morphologies were identified by HRTEM and HAADF-STEM characterization. Fourier transform infrared (FT-IR) analysis and thermogravimetric analysis (TGA) confirm the presence of chemically bonded oleic acid (OLA) on the CeO2 NC surface. It indicates that th... | 2023-01-01T17:44:45.682Z |
145,732,069 | {
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"DOI": "10.1177/002087287802100409",
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} | Practice a frustrating experience. The need to include in any single article a general programmatic description plus one or more vignettes of group interaction, with at least a bow in the direction of theory, while operating under restrictions as far as space is concerned leads to what must be described as a rather thin presentation. These articles are unlikely to be of much substantial help to the aspiring new group worke~r. Group elements and properties are little discussed. The emofiions of group participants are mentioned, but most of the articles do not discuss at any length how one tries to work with these. No reel sense is afforded of how group interaction is nurtured and stimulated. | 2022-02-09T06:23:09.722Z |
70,929,860 | {
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} | OZET Amac: Arastirmanin amaci bir devlet hastanesinde calisan hemsirelerin hasta bakiminda resmi olarak kullanmaya basladiklari hemsirelik sureci uygulamalarini degerlendirmektir. Yontem: Arastirmanin evrenini Erzurum’da bir egitim hastanesinde calisan hemsireler olusturdu. Arastirmanin orneklem grubunu ise 2012 Şubat ve Mart aylarinda bu hastane de calisan ve olasilikli ornekleme yontemi ile secilen 143 hemsire olusturdu. Arastirmada kullanilan veri toplama araci arastirmacilar tarafindan literatur isiginda hazirlandi. Bulgular: Arastirma sonuclarina gore, hemsirelerin en fazla agri (%28.7) ve enfeksiyon riski (%22.5) tanilarini koyduklari ve hemsirelerin %23.3’unun ise NANDA taksonomisi disinda yanlis tanilar koyduklari bulundu. Ayrica hemsirelerin en fazla uygulama (25.9) asamasinda gucluk yasadigi saptandi. Sonuc: Calismada, hemsirelerin hemsirelik surecinin basamaklarinda sorunlar yasadigi ve tani koymakta gucluk cektikleri belirlendi. Anahtar Kelimler: Hemsirelik sureci; hasta bakimi; hemsirelik. ABSTRACT Evaluation of the Applications Nursing Process Used in Patient Care by the Nurses Objective: The aim of this study was to evaluate the applications nurses working in a public hospital formally started to use the nursing process in patient care. Method: The study population consisted of the nurses who work an education hospital in Erzurum . The sample group of the study in February and March 2012 in Erzurum the education hospital employees and a total of 143 nurses who agreed to participate in the study created. Data collection instrument used in this study were prepared in the light of literature by researchers. Results: According to the study, nurses the more pain (28.7%) and increased risk of infection (22.5%) diagnoses put and 23.3% of nurses in the NANDA taxonomy outside put wrong diagnosis were found. In addition to nurses the application (25.9%) and planning (19.6%) had experienced difficulty in phase. Conclusion: In the study, the nurses problems experienced in some of the steps of the nursing process and have difficulty in diagnosis were identified. Keywords: Nursing process; nursing care; nursing. | 2022-02-11T11:11:13.789Z |
33,099,790 | {
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"DOI": "10.1111/j.1442-200X.1990.tb00825.x",
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} | We analyzed the relations between blood pressure in sitting and supine positions, left ventricular mass (LVM) and Doppler aortic, pulmonary and mitral flow velocity measurements in 163 healthy school children. Systolic blood pressure in a supine position correlated significantly with aortic acceleration (ATc) and ejection time)ETc), corrected by the square of R‐R interval, pulmonary AT and peak flow velocities. Moreover, the systolic blood pressure in a sitting position correlated with pulmonary AT and LVM. LMV correlated with pulmonary ATc, the ratio of AT to ET andaverage acceleration, and aortic ETc and peak flow velocity. These data suggest the following: (1) the posture influences the relation between blood pressure and flow velocity, (2) pulmonary hemodynamics are influenced by systemic blood pressure in healthy children and (3) the development of LVM may be dependentnot only on blood pressure but also on cardiac work in childhood. | 2022-02-12T10:25:12.492Z |
124,309,063 | {
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"DOI": "10.1299/kikaic.73.2072",
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"url": "https://www.jstage.jst.go.jp/article/kikaic1979/73/731/73_731_2072/_pdf"
} | The room transfer function (RTF) between the sound source and the evaluation point changes significantly according to their positions because of reflection. Therefore, the easy method to interpolate RTF at an arbitrary point with high precision must be developed. In this paper, a new method to interpolate RTF at an arbitrary point from the measured values at several points is proposed. The impulse response of RTF can be divided into the direct sound, early-reflected sounds and reverb sound. By closely located four point microphone method, the imaginary sound sources (ISS) of the early-reflected sounds at the measurement points are identified. The transfer function of early-reflected sounds at an arbitrary point can be interpolated from the identified ISSs. The transfer function of reverb sound at an arbitrary point can be interpolated linearly. The experiment in an office room showed that the interpolated value of RTF at an arbitrary point agreed with the measured value to some degree. | 2022-06-07T18:22:13.170Z |
44,124,443 | {
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"DOI": "10.1155/2018/9389570",
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"PubMedCentral": "5941796"
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"license": "CCBY",
"status": "GOLD",
"url": "http://downloads.hindawi.com/journals/jeph/2018/9389570.pdf"
} | The prevalence of asthma-related mortality (ARM) varies significantly among different countries, possibly influenced by various socioeconomic and environmental conditions (SEC). In-depth epidemiological research is necessary to understand the causal relationship between different SECs and ARM and to develop public health strategies to reduce the global burden of asthma. Our research aimed to identify the key SECs which may be attributed to ARM worldwide and to study the relationship between ARM and asthma prevalence. We included twenty-two countries with available data on SECs (2014-2015) and divided them into four groups: Asia, Africa, Europe, and Miscellaneous (Australia and North and South America). Tertiary school enrollment (TSE), gross domestic product (GDP), air pollution index, and male and female smoking prevalence rates were analyzed as predictors of ARM, using multiple linear regression. We found that ARM and asthma prevalence had an inverse relationship and developing countries compared to developed countries experienced higher ARM despite having lower asthma prevalence. Asian and African countries, compared to Europe and Miscellaneous countries, experienced poorer SECs, possibly associated with higher ARM. Among SECs, TSE and GDP had strongest association with ARM. In conclusion, lack of education and uneven distribution of resources may have an influence on the increased ARM in developing countries. | 2022-12-11T23:22:50.638Z |
161,048,644 | {
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"DOI": "10.1093/MIND/FZV160",
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} | This paper is a response to Paul Bartha’s ‘Making Do Without Expectations’. We provide an assessment of the strengths and limitations of two notable extensions of standard decision theory: relative expectation theory (RET) and Paul Bartha’s relative utility theory (RUT). These extensions are designed to provide intuitive answers to some well-known problems in decision theory involving gaps in expectations. We argue that both RET and RUT go some way towards providing solutions to the problems in question but neither extension solves all the relevant problems. | 2022-12-25T21:54:15.942Z |
33,039,222 | {
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"DOI": "10.1126/science.1178123",
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"url": "https://europepmc.org/articles/pmc2759711?pdf=render"
} | Anyone for d? The chemistry of amino acids comes in two chirally distinct flavors—so-called l- and d-enantiomers. By far the most commonly used form of amino acids in all kingdoms of life is the l-form. Now Lam et al. (p. 1552; see the Perspective by Blanke) present the unanticipated observation that diverse bacteria release large amounts of various d-amino acids into the environment in a population density–dependent fashion and that d-amino acids act as extracellular effectors that regulate the composition, structure, amount, and strength of peptidoglycan, the major stress-bearing component of the bacterial cell wall. Bacteria produce D-amino acids to regulate their cell wall composition, structure, amount, and strength. In all known organisms, amino acids are predominantly thought to be synthesized and used as their L-enantiomers. Here, we found that bacteria produce diverse D-amino acids as well, which accumulate at millimolar concentrations in supernatants of stationary phase cultures. In Vibrio cholerae, a dedicated racemase produced D-Met and D-Leu, whereas Bacillus subtilis generated D-Tyr and D-Phe. These unusual D-amino acids appear to modulate synthesis of peptidoglycan, a strong and elastic polymer that serves as the stress-bearing component of the bacterial cell wall. D-Amino acids influenced peptidoglycan composition, amount, and strength, both by means of their incorporation into the polymer and by regulating enzymes that synthesize and modify it. Thus, synthesis of D-amino acids may be a common strategy for bacteria to adapt to changing environmental conditions. | 2022-12-29T14:40:41.861Z |
202,356,082 | {
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"DOI": "10.4108/EAI.18-12-2018.2283841",
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} | In 20th century soft skills are a major differentiator, a sine qua non for employability and success, Heckman and Kautz (2012) [1] , the case of banking sector covering about 1, 49,163 branches of commercial banks in India is akin to this. There has been an increased focus on soft skills to hone leadership capabilities, enhance knowledge of rules and regulations of the industry (RBI report 2014) [2]. This research study strives to illustrate the role of soft skill training in reinforcing the employee performance in banking sector, and is a blend of empirical and conceptual research relying on the data from authentic sources. It was conducted in the city of Belagavi of Karnataka state to know whether soft skill training imparted to employees of banks at staff training colleges and other nodal bodies like NIBM can reinforce employee performance. Data analysis was done using statistical tests like regression, Anova in SPSS software. | 2022-04-21T13:11:10.341Z |
115,012,533 | {
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"DOI": "10.2495/TDI-V1-N3-359-370",
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} | In Japan, seating plans of reserved/non-reserved seats in intercity express trains do not necessarily correspond to passenger demands which may vary depending on many factors such as calendar days and operating sections. This mismatch possibly causes passengers’ incon-venience due to passenger congestions on board, and railway operators can lose revenue. Optimizing seating plans is expected to be an effective solution for these problems, where predicting both potential passenger demands and reflections to the potential demand caused by the passenger congestions is necessary. for establishing the prediction methods, we conducted some demand analyses and some questionnaire surveys. according to these results, we establish demand estimation models of reserved/non-reserved seats which can consider potential demands and behaviour changes if the passengers face congestion. We developed a prototype of seating plans optimization system applying these models, simulation of passengers’ behaviour and genetic algorithm. This paper describes these models, the optimization system and the result of applying this system to some existing intercity express trains as a case study. We got the optimized seating plan which is expected to improve both of the passengers’ convenience and the railway operators’ revenue. | 2022-08-31T19:50:42.365Z |
5,460,373 | {
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"DOI": "10.1287/trsc.1070.0202",
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} | This paper addresses the issue of convergence to equilibrium in dynamic traffic assignment. Within-day time is considered to be a continuous variable, so that traffic flows and costs are functions of within-day time. Flow propagates along routes connecting origin-destination (OD) pairs with the demand for travel between each OD pair considered to be rigid (fixed from day to day although it can vary within day). Day-to-day time is also modelled as continuous with the day-to-day dynamical system derived naturally from the usual dynamical user equilibrium (DUE) condition. This paper focuses on the bottleneck model, which has deterministic vertical queueing at bottleneck link exits when flow exceeds capacity. A new property called decay monotonicity is introduced. The link delay (and hence link cost) function is shown to be a decay monotone function of link flow provided that the link capacity is continuously differentiable and positive. In a restricted version of the single bottleneck per route case, it is shown that link cost decay monotonicity implies route cost decay monotonicity. Decay monotonicity of the route cost function is shown to be sufficient for convergence to equilibrium of the dynamical system. | 2022-11-24T18:21:32.312Z |
141,876,596 | {
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"DOI": "10.1037/e539332004-001",
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"url": null
} | *Every human being is 1. Like every other human being What do we all have in common? What is human nature? 2. Like some other human beings How do we satisfy our needs? 3. Like no other human being How do our individual genes and personal experiences contribute to our uniqueness? Human Nature and Individual Differences Description (What) Components of human nature Characteristics of individual differences Explanation (Why) Why do these components and characteristics come to be (origins)? How do they interact? How do they change over time? How are they functionally significant? | 2022-12-30T18:10:11.130Z |
88,634,704 | {
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"DOI": "10.1182/BLOOD.V116.21.2749.2749",
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} | Abstract 2749 Total WT1 expression is currently used for monitoring of AML patients and is of prognostic value also for CML patients according to our experience. Total WT1 level brings together levels of enormous amount of WT1 variants. Four major splicing variants reffered to as −5/−KTS, −5/+KTS, +5/−KTS and +5/+KTS are produced by combining two main independent splicing sites – exon 5 and KTS sequence. Short WT1 (sWT1) variant originates from usage of an alternative first exon E1a (Dalloso et al., 2001). Interestingly, exon 5 splicing was associated with resistance to apoptosis (Pritchard et al., 2006). The sWT1 was reported as overexpressed specifically in leukemias (Hossain et al., 2006). In view of literature data, we have suggested that splicing variant ratio or particular variant levels might have impact to leukemia pathogenesis, influence responsiveness to therapy and thus be a candidate for novel leukemic markers giving additional or more precise information about the disease state besides total WT1 levels. This idea was enhanced by our previous observation of differences of the four major variants levels associated with risk groups and different achieved responses to therapy among diagnostic AML patients samples (ASH 2009). In the current study, we extended our field of interest also on sWT1 vs. full length WT1. We aimed to find out whether there might be any advantage of monitoring of any of the WT1 variant in AML and CML patients undergoing therapy for more precise, sure and optionally earlier relapse detection/prediction. We have designed a novel method for quantification of sWT1 and full length WT1 separately. Quantification is performed by two separated real-time PCRs based on discriminating forward primers. One of those primers hybridizes onto exon 1 the other onto alternative exon 1a which enables to quantify full length WT1 and sWT1, respectively. For quantification of the four major variants, we used a method that we previously developed and reported (ASH, 2009). By introducing LNA nucleotides into the sequence of the primers with lowest hybridization efficiency we further improved reaction sensitivity, efficiency and robustness. Fourteen CML and ten AML patients undergoing therapy and developing haematological or molecular relapse were retrospectively analysed so far. We found out that the ratio of the four variants was changed in relapse as compared to diagnosis. The most abundant variant at diagnosis was +5/−KTS. In relapse, it became to be −5/+KTS in both AML and CML. The −5/+KTS was the first one to be increased in most of the cases and usually its expression kinetics was the most expressive of all four variants. As compared to BCR-ABL transcript, both total WT1 and −5/+KTS increases were more expressive or even earlier in some of CML patients and thus clearly predicted upcoming relapse. Short WT1 was detected in all AML samples, in CML we found it only in blast crisis not in the chronic phase samples. In all cases the proportion of sWT1 from total WT1 was very low, the majority of total WT1 was represented by full length WT1. Taken together, we showed that mainly −5/+KTS WT1 variant is a good marker of CML and AML and well characterizes the course of the diseases. Our preliminary data indicated that both kinetics and actual levels of −5/+KTS might specify information done by total WT1 levels and in case of CML by BCR-ABL making relapse prediction more sure or possibly even earlier. Supported by MZOUHKT2005. Disclosures: No relevant conflicts of interest to declare. | 2022-02-10T20:20:00.162Z |
37,029,419 | {
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"DOI": "10.1109/APPEEC.2011.5748818",
"MAG": "1967793271",
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"url": null
} | NA | 2022-02-12T07:10:55.725Z |
208,068,760 | {
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"DOI": "10.1177/120347540300700205",
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},
"license": null,
"status": "CLOSED",
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} | Background: Alopecia mucinosa has been shown to be associated with many benign and malignant conditions. It can be seen in childhood but is seen more commonly in adulthood. Alopecia mucinosa is generally felt to occur in three settings: a primary idiopathic form, a form associated with malignancy, and a form secondary to inflammatory conditions. The histologic hallmark is the accumulation of mucin in the follicular epithelium, called follicular mucinosis. Therapy for alopecia mucinosa remains problematic. Objective: We present a representative case of alopecia mucinosa and discuss the etiology, histology, epidemiology, treatment, and prognosis. Conclusion: We report a case of idiopathic alopecia mucinosa that responded to rninocycline with a complete remission and we review the literature on alopecia mucinosa. Sommaire Antecedents: La mucinose folliculaire semble associee ades maladies autant benignes que graves. Bien qu'elle puisse apparaitre chez les enfants, elle est plus frequente chez les adultes. La mucinose folliculaire se manifeste generalement sous trois formes: une forme idiopathique primaire; une forme associee a des tumeurs malignes et une forme consecutive a des maladies inflammatoires. Le signe histologique premier est l'accumulation de mucine dans l'epithelium folliculaire, d'ou son nom. Le traitement de la mucinose folliculaire reste problernatique. Objectif: Nous presentons un cas representatif de mucinose folliculaire et en examinons l'etiologie, l'histologie, l'epidemiologie, Ie traitement et Ie pronostic. Conclusion: Nous rapportons un cas de mucinose folliculaire primaire, traitee a la minocycline et guerie, et passons en revue les articles portant sur cette maladie. Journal of Cutaneous Medicine and Surgery Incorporating Medical andSurgical Dermatology DOl: 1O.1007/s10227-002-0103-8 J Cutan Med Surg 2003; 124-128 A lopecia mucinosa was first described by Hermann Pinkus in 1957. I His original report presented six patients. The pathologic features of these patients showed a unique type of follicular degeneration with accumulation of mucin and alopecia. I Pinkus noted that the condition occurred as solitary or multiple plaques, and if a plaque occurred on terminal hair-bearing skin, alopecia was prominent. Department of Dermatology, Penn State College of Medicine, Penn State .\lilton S Hershey .\ledical Center, Hershey, Pennsylvania, USA Online publication: 1i Novernnber 2002 Correspondence to: Bryan E. Anderson, Penn State College of Medicine, Penn State Xlilron S. Hershey Medical Center, Department of Dermatology HCH, CPC II, Suite ·1-300, 500 Universirv Drive. P.O. Box 850, Hershey, P.-\. 17033-0R50, CS.-\., E-mail: bandersoncepsu.edu . 124 Much has been learned and written about since Pinkus' report. Confusion and controversy still exist when discussing alopecia mucinosa (follicular mucinosis). The two terms, alopecia mucinosa and follicular mucinosis, are somewhat confusing. According to some authors the term follicular mucinosis should be applied to the histological pattern, and the term alopecia mucinosa should be used to describe the clinical dermatoses.i Therefore, hair loss secondary to follicular mucinosis is called alopecia mucinosa. Nevertheless, in practice and in the literature these two terms are used interchangeably. Follicular mucinosis is in itself a benign inflammatory reaction pattern; however, it may be associated with an underlying malignancy, most commonly cutaneous Tcell lymphoma. Therapeutic options for alopecia mucinosa are limited. We report a case of alopecia mucinosa successfully treated with minocycline. B. E. Anderson et al. Alopecia Mucinosa 125 FIGURE 1 Patient's initial presentation. | 2022-03-07T19:54:11.372Z |
204,953,361 | {
"externalids": {
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"DOI": "10.1111/imj.14671",
"MAG": "2982456344",
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} | The clinical relevance of bilateral pleural effusion (BPE) in patients with acute pulmonary embolism (PE) is unclear. | 2022-07-28T02:18:13.541Z |
204,884,192 | {
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"DOI": "10.1097/MD.0000000000016989",
"MAG": "2981516458",
"PubMedCentral": "6824666"
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} | Abstract Periprocedural myocardial injury (PMI) and contrast-induced nephropathy (CIN) are frequent complications of percutaneous coronary intervention (PCI) associated with early and late major adverse cardiovascular events. Both conditions are associated with similar risk factors, which could imply their possible association. The aim of our study was to assess the correlation of PMI and early postprocedural creatinine shift (ECS) as a marker of renal injury. A total of 209 hospitalized patients with stable coronary artery disease (CAD) were enrolled, who underwent an elective PCI in a period of 12 months. All patients had their serum high-sensitivity troponin I (hsTnI) measured at baseline and 16 hours after the PCI. PMI was defined according to the elevation of postprocedural hsTnI using criteria provided by both the most recent consensus documents as well as evidence-based data. Renal injury was evaluated using the ECS concept. Serum creatinine (SCr) was also measured at baseline and at 16 hours. ECS was defined as SCr >5% at 16 hours compared to baseline. Although incidence of both PMI (77.5%) and ECS (44.5%) were high, no association of these 2 conditions could be found. Further analyses of our data showed that diabetes is associated with a higher incidence of ECS, while patients on beta-blocker therapy had a lower incidence of ECS. In our study, no association between PMI and ECS was found. Additional studies with a larger number of patients and longer patient observation are needed to assess the correlation between PMI and CIN as well as to validate the attractive, but controversial, concept of ECS as an early marker of CIN. | 2022-09-08T04:13:53.295Z |
248,142,582 | {
"externalids": {
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"DOI": "10.51189/conbiotec/60",
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} | Introdução: As orquídeas, pertencentes a família Orchidaceae, são muito utilizadas comercialmente para a venda de arranjos ornamentais e, devido a isto, são retiradas excessivamente da natureza, levando muitas delas à extinção. Desta forma, o cultivo in vitro apresenta-se como alternativa para estudos e métodos de conservação para redução de risco de extinção. Objetivo: O objetivo deste trabalho foi avaliar a influência do meio de cultura na germinação in vitro de sementes de E. carpophorum, com o intuito de facilitar o desenvolvimento de um protocolo eficiente de micropropagação dessa orquídea. Material e métodos: O trabalho foi realizado no Laboratório de Biotecnologia da Universidade Federal Rural da Amazônia. A metodologia do trabalho iniciou-se com a coleta de cápsulas imaturas de E. carpophorum no Orquidário Bosque Rodrigues Alves e, posteriormente, foram acondicionadas até o início do processo de assepsia e germinação. Após a assepsia em câmara de fluxo laminar, foram utilizados diferentes meios de cultura, distribuídos nos tratamentos: T1= meio MS (Murashige & Skoog), T2= meio MS + carvão ativado (2,5gL-1), T3= metade dos sais do MS e T4= metade dos sais do MS + carvão ativado. Após inoculação das sementes, os frascos foram mantidos em câmara tipo B.O.D com fotoperíodo de 16h e temperatura de 27ºC. Foram feitas análises qualitativas da germinação, sendo consideradas àquelas sementes que apresentaram protocormos de coloração verde e bom desenvolvimento. Resultados: Os tratamentos com meio MS sem carvão ativado (T1 e T3) apresentaram elevada germinação dos protocormos à medida que foram realizadas as avaliações, o tratamento T1 apresentou melhores resultados em comparação ao T3. Já os tratamentos com meio MS com carvão ativado (T2 e T4) apresentaram rápido entumescimento e melhor desenvolvimento dos protocormos. Ressalta-se que o tratamento T4 apresentou os melhores resultados de germinação e desenvolvimento dentre os demais tratamentos. Estes resultados demonstraram a influência do carvão ativado no desenvolvimento dos protocormos de orquídeas, possivelmente devido a capacidade de maior absorção de nutrientes em meios que contém este tipo de aditivo. Conclusão: Portanto, nota-se que a presença do carvão ativado e o uso de metade do meio de cultura MS pode estimular a germinação e o desenvolvimento in vitro de E. carpophorum. | 2022-04-14T16:29:13.491Z |
135,659,772 | {
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"DOI": "10.1177/0731684407079413",
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} | This study investigates initiation and propagation of damage zones in the composite plates of an adhesively bonded single lap joint under flexural loads at the mesoscale level based on Tsai—Wu and Hashin failure criteria. The damage zones were evaluated in the unidirectional composite plates with ply lay-ups [0]10, [15]10, ... , [90]10. The mechanical properties of each failed ply of the upper and lower plates were modified based on a set of material degradation rules. Due to stress concentrations along the free edges of the adhesive layer and in the corresponding zones of the lower and upper plates, the peak stresses appeared along the left free edge of the upper plate—adhesive interface. Both failure criteria showed that the damage initiated in the first ply of the upper plate interface to the adhesive layer and propagated through this ply along this adhesive free edge, and then expanded through the neighboring plies in a similar failure mechanism. Hashin failure criterion predicted that the matrix and ... | 2022-11-20T18:10:38.842Z |
25,900,848 | {
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"ArXiv": null,
"DOI": "10.2174/138620711795222437",
"MAG": "2102838659",
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} | Prime concerns with modern developments are attributed to high level undetected but important biological substances or even toxicants cycled often among individual and populations; which in turn agonizes environmental monitoring, trace-gas detection, water treatment facilities, in vivo detection in biological fluids and other accomplishments. For the detection of such analytes, several analytical devices combined with biological component have been designed with a physiochemical detector component. Here, we essentially focus on drug-based potentiometric membrane sensors known as ion selective electrodes (ISEs). The functionality of ion-selective membrane is quite intricate, challenging, and our understanding is yet to be thrived with more interventions. ISEs have applied explications to enormous variety of analytical inquires as well as informative tools for probing host-guest chemistry. However, expansion of ISEs based applications is aimed to improve the system performance, acquiring enhanced understanding of their response mechanism, and finding new chemical or physical configurations mainly for human welfare. The major strength of ISEs is the precised analytical information, assured by using the ion-selective membrane electrodes used successfully for both in vitro and in vivo assays of pharmaceutical products as well as in clinical analyses. In this review, we attempt to provide a brief prologue to the applicability and advantages of potentiometric sensors in the analysis of pharmaceutically active compounds emphasizing their employment at molecular level for in situ selection of biologically important analytes. | 2022-12-19T05:49:09.052Z |
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