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230,617,052 | {
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"DOI": "10.1155/2020/2412491",
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} | In this paper, we investigate on the number of all possible real matrices representing a quaternion number as three
4
×
4
skew-symmetric matrices plus the identity matrix of order 4, and how to determine these matrices. We establish that there are 96 distinct real matrices having this property, and by matrix row operations, we obtain these matrices. | 2022-09-07T09:34:17.265Z |
151,771,316 | {
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"DOI": "10.21776/UB.ARENAHUKUM.2017.01001.8",
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} | Abstract Testament is the last will of a testator toward his wealth that will be executed after death. Each type and form of the will can be made either in an authentic deed before a public notary or privately made deed. The duty and responsibility of notary is to save and send a list of wills that have been made to the Property and Heritage Agency (BHP) and Central Register of Wills (DWP). In order to implemet the efficiency of the registration system, on March 28, 2014, the Ministry of Justice and Human Rights of the Republic of Indonesia (hereinafter referred to as Kemenkumham) has launched the online system for wills registration by the Notary. But in practice, there are still many who have not registered Notarial wills online to Kemenkumham. From this condition the issue is regarding the legal effect of the deed not registered online and the liability of notaries who do not register the will online. This paper is a normative legal research using statute, conceptual and historical approach. The study concluded that the status of a will that is not registered online at Kemenkumham is still as authentic documents, but it does not meet the principle of publicity that may result in the lack of knowledge of the heirs or the third parties. If there are losses, then heirs may sue the notary on the basis of onrechtmatigedaad where the notary did not meet its legal obligations. Abstrak Wasiat merupakan kehendak terakhir dari seorang pewaris terhadap harta kekayaan miliknya yang harus dilaksanakan setelah ia meninggal dunia. Notaris bertugas dan berkewajiban untuk menyimpan dan mengirim daftar wasiat yang telah dibuatnya ke Balai Harta Peninggalan (BHP) dan Daftar Pusat Wasiat (DWP). Dalam rangka untuk mewujudkan efisiensi dari sistem pendaftaran tersebut, pada tanggal 28 Maret 2014, Kementerian Hukum dan HAM Republik Indonesia (selanjutnya disebut Kemenkum HAM RI) melakukan launching sistem pendaftaran wasiat secara online oleh Notaris. Namun pada prakteknya masih banyak Notaris yang belum mendaftarkan wasiat secara online ke Kemenkum HAM RI. Dari hal tersebut muncul isu hukum mengenai akibat hukum dari akta wasiat yang tidak didaftarkan secara online dan mengenai tanggung gugat notaris yang tidak mendaftarkan wasiat secara online. Penelitian ini adalah penelitian hukum normatif, menggunakan pendekatan undang-undang ( statute approach ), pendekatan konseptual ( conceptual approach ) dan pendekatan historis ( historical approach ). Hasil penelitian menyimpulkan bahwa kedudukan akta wasiat yang tidak didaftarkan secara online pada Kemenkumham adalah tetap sebagai akta otentik, namun tidak memenuhi asas publisitas yang dapat membuat pihak ketiga atau ahli waris dianggap tidak mengetahui adanya suatu wasiat yang ditujukan bagi mereka. Apabila terdapat kerugian yang ditimbulkan, maka ahli waris dapat menggugat notaris atas dasar perbuatan melanggar hukum dimana notaris yang bersangkutan tidak memenuhi kewajiban hukumnya. | 2022-03-04T11:33:02.464Z |
214,009,587 | {
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"DOI": "10.36841/cermin_unars.v3i2.488",
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"url": "https://unars.ac.id/ojs/index.php/cermin_unars/article/download/488/408"
} | Media sosial memiliki peranan besar dalam merubah gaya hidup dan hubungan sosial para penggunanya. Dalam bidang pemasaran, media sosial dimanfaatkan para pemasar bukan hanya untuk berpromosi, namun juga untuk membina hubungan dan menciptakan citra positif melalui kegiatan komunikasi dua arah secara timbal balik, yang akhirnya akan berimbas pada kepercayaan dan peningkatan hasil penjualan produk. Kemudahan, kecepatan, serta daya jangkau media sosial yang sangat luas membuat program pemasaran menjadi efektif dan efisien, kegiatan promosi dapat berlangsung secara cepat dengan biaya yang rendah. Viral marketing yang tercipta memungkinkan isi pesan promosi menyebar secara cepat dan menjangkau banyak pengguna media sosial di berbagai wilayah. Namun, viral marketing juga memiliki berbagai kelemahan yang harus diantisipasi agar tidak menghambat atau menghancurkan program pemasaran yang dilaksanakan. Minat beli konsumen yang didasarkan pada konsep AISAS (Awareness – Interest - Search – Action - Share) harus dipahami oleh setiap pemasar dalam membuat dan menerapkan strategi pemasaran. Dalam penelitian kualitatif ini diuraikan berbagai faktor yang dapat mendukung maupun menghambat kesuksesan viral marketing, serta berbagai fasilitas di media sosial yang dapat dimanfaatkan dalam kegiatan pemasaran. Small and Medium Enterprises (SMEs) dan Sony BMG Music merupakan contoh para pelaku usaha yang merasakan langsung dampak terjadinya viral marketing, baikdampak positif maupun negatif. | 2022-06-06T09:20:47.597Z |
247,698,992 | {
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"DOI": "10.1111/1467-9639.00047",
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} | Environmental statistics is an exciting and rapidly growing area of statistical application. It requires complex new approaches and methods to be developed, to enable study of the crucial environmental problems we face: whether climate change, passive smoking, industrial pollution or forest fires. For the classroom, environmental statistics can bring some reality and immediacy to our teaching. | 2022-07-09T18:55:08.365Z |
83,692,238 | {
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"DOI": "10.1002/047120918X.EMB1470",
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} | Steroid hormone receptors (SHRs) are ligand-activated transcription factors and the key mediators of steroid hormone action. Lipophilic steroid hormones pass the cell membrane of target cells by simple diffusion and bind to soluble intracellular SHRs that are complexed to chaperones or to a small fraction of membrane-tethered SHRs. The binding of agonistic or antagonistic ligands leads to different allosteric changes of receptors, making them competent to exert positive or negative effects on the expression of target genes by different mechanisms. | 2022-08-20T09:36:26.798Z |
230,485,301 | {
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"url": "https://doi.org/10.17219/acem/114339"
} | BACKGROUND
Leucoderma, a depigmentation of the skin, is a common disease in humans, and has been observed in cattle, horses and buffalo as well.
OBJECTIVES
To analyze the correlation between melanin stem cells and the differentiation and proliferation of melanocytes (MCs).
MATERIAL AND METHODS
Magnetic cell separation was used to separate melan-A+ cells and PAX3+ cells, which were cultured in vitro. The L-DOPA staining was used to observe cell morphology; Cell Counting Kit-8 (CCK8) was used to determine the cell proliferation rate; and flow cytometry (FCM) was used to determine cell cycle changes. The relative mRNA levels of melanocyte-inducing transcription factor (MITF), dopachrome tautomerase (DCT) and melan-A in cells were determined with reverse-transcription polymerase chain reaction (RT-PCR).
RESULTS
The number of MC dendrites increased and extended continually during in vitro culture following magnetic cell separation. The proportion of positive L-DOPA staining cells increased from a baseline 40.70% to 82.03%, and the cell proliferation rate increased from 335.0% at D3 to 1577.4% at D20. The results of FCM showed that the cell proportion at the G1 stage in the D20 group was significantly lower than the D3 group; the cell proportion at the G2/M stage also decreased significantly. The expression of MITF and melan-A increased as the culture time increased, while the expression of DCT decreased.
CONCLUSIONS
The number of MC stem cells decreased and mature MCs increased gradually, indicating that MC stem cells can gradually differentiate into mature MCs during in vitro culture following magnetic cell separation. | 2022-12-17T08:12:59.459Z |
216,279,704 | {
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"DOI": "10.24127/ajpm.v9i1.2641",
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"status": "GOLD",
"url": "https://ojs.fkip.ummetro.ac.id/index.php/matematika/article/download/2641/pdf"
} | Penelitian ini bertujuan untuk mengidentifikasi strategi dan level pemahaman intuitif siswa sekolah dasar dalam mengukur luas jajargenjang. Jenis penelitian yang digunakan adalah studi kasus. Teknik pengambilan data dilakukan dengan cara pemberian tugas, observasi, wawancara dan dokumentasi. Teknik analisis data yang digunakan adalah reduksi data, penyajian data, dan penarikan kesimpulan/verifikasi. Penelitian ini menemukan adanya dua strategi pemahaman intuitif yang baru yaitu strategi visual-kongkrit dan pengukuran estimasi. Sementara itu, ada dua level transisi pemahaman intuitif meliputi level 2: penutupan visual kongkrit dan level 4: penutupan susunan yang dikonstruk melalui estimasi pengukuran. Level pemahaman intuitif siswa yang dikonstruksi dari jenis-jenis strategi tersebut secara bertahap dapat mencapai level pemahaman intuitif, yaitu level 0 sampai level 6. Temuan penelitian ini berimpikasi pada level pemahaman intuitif siswa dalam mengukur luas daerah yang lebih rinci dan berhirarki. Hasil penelitian ini menyarankan agar siswa dapat mencapai pemahaman relasional atau memiliki konsep pengukuran luas yang bermakna, para pendidik khususnya di tingkat sekolah dasar harus menstimulasi pembelajaran menggunakan tugas-tugas pemahaman intuitif secara bertahap dan tidak hanya dibangun melalui pengukuran luas persegipanjang. Abstract This study aims to identify strategies and levels of intuitive understanding of elementary school students in measuring the area of a parallelogram. This type of study is a case study. Data collection techniques carried out by giving tasks, observation, interview and documentation. Data analysis techniques used are data reduction, data presentation, and drawing conclusions/verification. This study has founded two new intuitive understanding strategies namely visual-concrete and estimation measurement strategies. Meanwhile, there are two levels of intuitive understanding transitions including level 2: visual –concrete covering and level 4: Array covering constructed by measurement estimation. The level of students' intuitive understanding constructed from these types of strategies can gradually reach the level of intuitive understanding, level 0 to level 6. The findings of this study imply the level of students' intuitive understanding in measuring the area in a more detailed and hierarchical area. The results of this study suggest that students can achieve a relational understanding or have a meaningful broad measurement concept, educators, especially at the elementary school level, must stimulate learning using intuitive understanding tasks gradually and not only be built through rectangular area measuremen t. | 2022-04-22T04:37:22.730Z |
192,326,961 | {
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"DOI": "10.25267/TROCADERO.2018.I30.09",
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} | The magic of love in Cuba is a syncretic corpus of great influence in the current belief systems (Santeria, Palo Monte and Espiritismo), documented in the inquisitorial processes of the colonial period. This article questions the fact that recent historiography considers the magic of love as exclusive of indigenous and African women, product of the feminine subversive desire. Our aim is to demonstrate, through historical documents and ethnographic interviews, that men were and are protagonists of the magic of love in Cuba, that it cannot be considered subversive and that it has been influenced by white-European tradition. | 2022-04-22T05:00:44.245Z |
249,965,195 | {
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"DOI": "10.4028/p-88h8ly",
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} | In the field of food cooling and freezing computation, the accurate determination of thermo-physical properties such as specific heat, thermal conductivity and density is necessary and specially important to optimize the energy consumption of equipment. These parameters depend on the food composition and temperature usually determined by theoretical or experimental method or the combination of both. Experimental method using differential scanning calorimetry (DSC) is the best approach to yield correct results. However, DSC method requires expensive equipment and it might be not suitable for limited funding in some Vietnamese research centers. Therefore, the line heat source was chosen in this study.This paper introduces a new approach to determine thermal properties of the Vietnamese Pangasius in the temperature range from-40 °C to +40 °C using the line heat source. The results indicated that there is good correllation between the obtained measured data and the results calculated using theoretical models as well as other published experimental results. | 2022-08-20T13:04:46.039Z |
25,491,545 | {
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"DOI": "10.1111/j.1365-2753.2008.00988.x",
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} | OBJECTIVE
To determine the reliability of a generic index such as Simplified Acute Physiology Score II (SAPSII), compared with a specific one Intra Cerebral Haemorrhage score (ICH score), as an intensive care unit (ICU) outcome predictor when evaluating a general facility that frequently treats a specific type of patients - those with spontaneous cerebral haemorrhage.
METHODS
The study cohort consisted of a random sample of patients (81) admitted to Modena's Policlinico Teaching Hospital's ICU with spontaneous ICH over a 24-month period. Main outcome measure SAPSII, ICH score, overall mortality.
RESULTS
The mean ICH score for the 32 surviving patients was 3.41 +/- 1.012 while for the 49 deceased patients was of 4.24 +/- 0.855 (P = 0.000). The mean SAPSII value for the 32 surviving patients was 49.09 +/- 16.58 while for the 49 deceased patients was 49.51 +/- 15.93. SAPSII, ICH scores were analysed for mortality, by receiver operating characteristic curves: the area under the curve was significant for ICH, not-significant for SAPSII.
CONCLUSIONS
Regional quality controls use generic prognostic indexes (SAPSII) in relation to mortality and outcome to assess ICUs, which is appropriate when dealing with a general facility when there is not a predominant type of patient, but it may bias the evaluation if the population with specific pathologies (ICH), not included in the general index, is statistically considerable, leading to an incorrect criticality assessment, an inappropriate strategic plan and the subsequent inefficient resource allocation. | 2022-02-12T18:11:17.924Z |
60,445,722 | {
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"ArXiv": null,
"DOI": "10.5772/36851",
"MAG": "1482085135",
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"license": "CCBY",
"status": "HYBRID",
"url": "https://doi.org/10.5772/36851"
} | Audio watermarking (AW) corresponds to digital information imperceptibly embedded into the audio signal. AW for maritime VHF (Very High Frequency) communication is inspired first of all by the ability of implementation an automatic identification of radiotelephone transmissions in the channels of maritime (156...174) MHz mobile radio communication service. Applied to VHF radiotelephony, a watermarking system could overcome existing limitations, and ultimately increase safety and efficiency of maritime communication. The same application of AW may be implemented in the aeronautical (118...136) MHz mobile service. In the mentioned services analogue broadcasting channels with frequency/phase and amplitude modulation correspondingly are utilized. | 2022-08-26T13:45:57.368Z |
208,327,047 | {
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"DOI": "10.1182/BLOOD.V116.21.1873.1873",
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} | Abstract 1873 Background: CMML, now classified among MDS/MPN, is prognostically heterogeneous. We (JCO 1988 6:1417, Blood 1996 88:2480) and others found prognosis in CMML to depend on both “MDS factors” (% marrow blasts, cytopenias, karyotype) and “MPN” factors, ie splenomegaly (SMG), WBC count, extramedullary disease (EMD). Treatment of advanced CMML is difficult. The hypomethylating agents Azacitidine and Decitabine (DAC) have shown efficacy in CMML, but in prognostically heterogeneous cohorts. We conducted a phase II trial of DAC in a well defined cohort of advanced CMML. Methods: To be included, CMML (according to WHO) should have: if WBC 5cm below costal margin, (SMG>5cm), EMD, based on our previous prognostic factors. Pts received DAC 20mg/m2/d IV for 5 days every 28 days for at least 3 cycles. Response criteria were based on IWG 2006 for pts with WBC 13 G/L also included evolution of WBC, SMG and EMD (Blood 1996 88:2480). Results: Between Nov 2008 and June 2009, 41 pts were included in 16 centers, of whom 39 completed at least one cycle and were considered evaluable for response (the 2 other pts died from septic shock before and during the first cycle respectively). Median number of cycles was 9 (range 1–17). Median age was 71 years (range 54–88), M/F:30/9. Seventeen pts had CMML 1 and 22 had CMML 2 (including pts with up to 29% marrow blasts). Median WBC count was 29.5G/l (range 4.1–147.3), median blood monocytes 3G/l (range 1.05–95.7), and median BM blasts 10% (1-29). Nine pts had WBC 5cm and 8 (20.5%) EMD involving skin (n=5) and lymph nodes (n=3). Overall Response Rate (ORR,) was 38.6% with 4 (10.3%) CR, 8 (20.5%) marrow CR and 3 (7.7%) Stable Disease (SD) with HI. 1 CR pt received allo SCT. 18 (46%) pts had SD without HI and 6 (15.4%) pts progressed to AML. 8 (36.4%) of the 22 RBC transfused pts became RBC transfusion independent. 3/10 (30%) pts with plt 100G/l. Four pts had cytogenetic response (3 CR and 1 PR) exclusively among pts with +8. Median peripheral monocyte count decreased from 4.8G/l to 0.3G/l after 3 cycles of DAC among responders. SMG disappeared in 6/15 (40%) pts and EMD in 6/8 (75%) pts. 16 pts were receiving Hydroxyurea (HY) at inclusion which could be stopped in 12 of them. With a median follow up of 10 months (1-18), 7 pts had died from progression (n=3), sepsis (n=3) and unrelated cause (n=1). Overall Survival (OS) estimate was 60% at 2 years (median not reached). By comparison, in our previous trial of HY in CMML where inclusion criteria were the same, 2 year survival was 43% (median OS 20 months; Blood 1996 88:2480), for a median follow up of 11 months (range1-43). The only factor associated with response to DAC was WHO subtype, CMML 2 pts showing significantly better ORR (30.8% vs 7.7% in CMML 1; p=0.041).There was no difference in survival between CMML 1 and 2 pts. Treatment with DAC was generally well tolerated with, except for usual grade 3/4 cytopenias, and grade 3 fatigue (n=1). Conclusion: DAC is active in advanced CMML and safe in these elderly pts. A possibly better survival than with HY will have to be confirmed in randomized trials. Correlative genetic studies identifying markers potentially predicting response and survival for DAC are currently underway in our lab. Disclosures: No relevant conflicts of interest to declare. | 2022-02-08T03:55:29.911Z |
3,130,257 | {
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"DOI": "10.1099/vir.0.041038-0",
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"url": "https://doi.org/10.1099/vir.0.041038-0"
} | In 2006, a new retrovirus was isolated from prostate cancer patient tissue. Named xenotropic murine leukemia virus-related virus (XMRV), this was potentially the third class of retrovirus to be pathogenic in humans. XMRV made a more dramatic impact on the wider scientific community, and indeed the media, in 2009 when it was reported to be present in a remarkably high proportion of patients with chronic fatigue syndrome as well as a significant, albeit smaller, proportion of healthy controls. The apparent strong link to disease and the fear of a previously unknown retrovirus circulating in the general population lead to a surge in XMRV research. Subsequent studies failed to find an association of XMRV with disease and, in most cases, failed to find the virus in human samples. In 2011, the case against XMRV and human disease strengthened, ending with several decisive publications revealing the origin of the virus and demonstrating contamination of samples. In this review, we outline the passage of research on XMRV and its potential association with disease from its isolation to the present day, where we find ourselves at the end of a turbulent story. | 2022-09-11T13:49:02.501Z |
59,569,754 | {
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"DOI": "10.14419/IJET.V7I3.2.14403",
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} | The supposition of productivity gain of finishing work using plastering machines has been considered in the article. The work of constituent parts of plastering machines has been studied. The working parameters of the plastering machine has also been calculated. There has been evolved the planning of a three-factor experiment of the second order with the aim of determining the working power, consumed by the mortar pump. | 2022-12-02T11:48:59.078Z |
254,723,319 | {
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"DOI": "10.7202/1094698ar",
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"url": "https://www.erudit.org/fr/revues/bioethics/2022-v5-n4-bioethics07538/1094698ar.pdf"
} | Analgesia and amnesia represent two complimentary pillars of anesthesia directed, respectively, at mitigating the experience of pain and the processes of encoding that experience into memory. These elements are typically combined in modern anesthetic techniques, but some circumstances exist – such as conscious sedation – in which the conditions of amnesia are satisfied while analgesia plays an auxiliary and often incomplete role. These activities reflect a widely held yet underrecognized belief in clinical practice that although pain experiences | 2022-12-31T18:59:53.763Z |
161,103,463 | {
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} | nun stellt nicht ‘authentische’ Texte her, sondern deren Kontexte, und zwar nicht nur die der Vergangenheit (die Entstehungskontexte), sondern auch deren Fortwirken auf den Text (etwa in Form von Überlegungen zu Umarbeitungen bei späteren Veröffentlichungen), bis hin zu Ideen von Fortsetzungen oder Änderungen, die nie ausgeführt wurden, und die Momme Mommsen treffend der “latente[n] Entwicklungsgeschichte” (Bd. I, xx) zurechnet. Ein Schwerpunkt der EGW liegt auf der ausführlichen Berücksichtigung der Werke Goethes zur Naturwissenschaft, zu dem die Dokumente einen hilfreichen Zugang gewähren. Mommsen ging 1958 mit Grund noch davon aus, daß der Dichter und der Wissenschaftler Goethe von den akademischen Disziplinen und—entsprechend—von Forschern kaum als eine im Werk präsente Einheit wahrgenommen werden konnte. Ganz sicher ist eines der Verdienste der EGW, die Goetheschen Schriften in ihrem gesamten Umfang (mit den genannten Ausnahmen), d.h. Dichtung, amtliche Schriften und naturwissenschaftliche Forschungen zusammengenommen, in ihren kontextuellen Verfl echtungen zu dokumentieren. Daß der “Werk”-Begriff dabei “nicht ganz eng gefaßt” (Bd. I, xxxvi) wird, trägt zur Erschließung neuer Dimensionen in der GoetheForschung bei. Kein -ismus-Vertreter und kein professioneller Goethe-Leser, kein GoethezeitSpezialist, auch kein Sozialhistoriker, der sich mit dieser Zeit und dem Phänomen Goethe auseinandersetzt, kein New Historicist, kein gestandener Marxist, Biographisten und Kontextualisten sowieso, auch Positivisten, Dekonstruktivisten (und sei’s heimlich), Kulturhistoriker, Strukturalisten und deren Postler, Hermeneutiker, gleich welcher couleur, aber auch Phänomenologen, Rezeptionsästhetiker und Psychoanalytiker, von Cultural Studies-Anhängern bis zu Anhängern der Ethnic, Race und Gender Studies—sie alle können nur profi tieren von dieser Dokumentation. Sie mag so manches auf den ersten Blick Obskure enthalten, dieser Eindruck legt sich aber in der Regel rasch nach Lektüre der Bezugstexte. Man muß auch nicht unbedingt Momme Mommsens Vorstellung von Literaturwissenschaft als Morphologie im Goetheschen Sinne folgen, obwohl das nicht der unergiebigste Rat ist. Zudem sollten sich Benutzer der EGW nicht von der theoretischen Unbedarftheit der Einleitung des 3. Bandes verstören lassen: Was zählt, ist das Produkt. Ohne Zweifel macht diese Dokumentation— Mommsens Bescheidenheitstopos für das Unternehmen ist “dokumentarisches Supplement”—vielen Spekulationen über Goethes Werke den Garaus. Kurz: EGW gehört in jede seriöse Bibliothek. Studierende können immens lernen über das 18. und 19. Jahrhundert, und zwar ohne nur scheinbar bequemen, vorschnellen Generalisierungen zu verfallen. Experten wird das Werk ein Handbuch werden. Zu wünschen ist eine zügige Weiterführung der Ausgabe, zu der, wer sich berufen fühlt, beitragen kann. Informationen zur Ausgabe: http://www.goethe.uni-goettingen.de/ | 2022-02-08T22:24:00.965Z |
89,367,484 | {
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} | Abstract 4201 Introduction Factor XIII deficient patients may present at any age, with a variety of bleeding symptoms, poor wound healing, and in females, frequent miscarriages. Factor XIII (FXIII) is a transglutaminase enzyme that was first discovered as a clotting protein in the coagulation cascade, but it is now understood that it cross-links proteins in the plasma, vascular matrix, endothelial cells, platelets and monocytes. In addition to maintaining normal hemostasis, FXIII plays a role in atherosclerosis, wound healing, inflammation, and pregnancy. FXIII circulates in plasma as a tetramer protein (FXIII-A 2 B 2 ) held together by non-covalent bonds. FXIII has two catalytic A subunits (FXIII-A 2 ) of 83kd and two non-catalytic B subunits or carrier subunits (FXIII-B 2 ) of 79kd. Mutations have been identified in almost every exon of the FXIIIA subunit and often are unique to a particular cohort or family with Factor XIII deficiency. Our center has been characterizing patients with FXIII deficiency and has an IRB approved study to characterize bleeding phenotype in relation to genotype or mutational analysis. As part of this effort, we have identified 3 novel missense mutations, which we have not found in the FXIII database ( ) or in previous publications. Methods After obtaining informed consent, venous blood was collected in EDTA tubes for DNA isolation, PCR and ultimately DNA sequencing. DNA was isolated using QIAamp DNA Blood Midi Kit (Qiagen, Germantown, MD). Customary PCR was used to amplify the 15 exons for subunit A and the 12 exons for subunit B, using sequence specific primers based on previous publication and created to initiate outside of the encoding sequence. The nucleotide sequencing of amplified products was obtained via ABI 3730 DNA Analyzer (UCLA Sequencing and Genotyping Core). Results All three novel mutations were found in three, separate, unrelated individuals, with FXIII deficiency diagnosed early in life with a moderate to severe bleeding. Using the methods described above, the DNA sequencing and analysis for all exons for both the A and B subunits revealed three novel mutations, two on exon 12 subunit A and one on exon 10 subunit A. Patient 1 has a novel missense mutation in exon 10 at the 427 amino acid position, changing the aspartic acid into an asparagine (Asp427Asn) in the catalytic core. Patient 2 and 3 each had a unique mutation in exon 12. Exon 12 covers the transition from the catalytic core region and the Barrel 1 region of the FXIIIA molecule thus including portions of each functional region. Patient 2: An exon 12 missense mutation in aa 501 resulting in a change from glycine to an arginine (Gly501Arg) still in the catalytic core region. Patient 3 also had a mutation in exon 12 but in position 576 resulting in an amino acid change from threonine to methionine (Thr576Met) now in the Barrel 1 region. Patient 2 also had a missense mutation that has been previously reported in exon 3 (Arg77His) in the β-sandwich region. Three new missense mutations have been identified in patients with severe Factor XIII deficiency and a bleeding disorder. Previous reports of other point mutations in the FXIIIA catalytic core and barrel 1 regions have also been described in association with a hemorrhagic state in deficient patients. Ongoing protein expression studies will aid in our understanding of how these single amino acid substitutions result in such a serious bleeding diathesis. Disclosures: No relevant conflicts of interest to declare. | 2022-02-10T19:47:27.356Z |
62,233,175 | {
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} | In the field of the scientific co-operation between the authors' two Institutes, started in 1986, a common research program was developed for the analysis of the characteristics and the application of advanced spaceborne optical sensors for remote sensing of the Earth. This program has become a part of the international scientific project Priroda, which combines efforts of scientists from Bulgaria, Czekhia and Slovakia, France, Germany, Independent States Community, Italy, Poland, Switzerland, and USA. The space module Priroda is the technical base for the project. It will be launched and attached to the inhabited space platform MIR at the end of 1995. By means of the optical sensors placed on board of the Priroda module, the authors are going to study the geophysical parameters useful for environmental monitoring and resources evaluation in Italy. Taking into account the characteristics of different sensors and utilising both experimental data available now and coming from similar sensors placed on aircraft or spacecraft and suitable models, they are estimating the possible applications of such new sensors over some test sites in the Tuscany region. | 2022-02-11T14:47:24.148Z |
143,979,648 | {
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} | Biomedical constructions of health and illness as objective categories have long been challenged by social theorists. As part of this critique, an analytic distinction is made between the domains of doctors and patients to highlight differences in perspective and power. Illness narratives and phenomenological studies foreground how patient experiences and understandings of health are complex, socially embedded and often conflict with medical models. This article, however, asks how patients make sense of their health at the interface of these domains. This question is explored with reference to 16 men living with HIV and the ways in which they negotiate medical discourse and technology in relation to lived experience and, conversely, how they interpret their own bodily symptoms in light of clinical construction of health. These negotiations contest the authority of biomedical definitions, but also reveal a more dynamic and technologically mediated negotiation within patient experience than some phenomenologically oriented theories on health allow. | 2022-12-17T11:51:18.533Z |
90,412,090 | {
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} | ABSTRACT A total of 30 surface soil samples were collected from the typical polluted area of Bengbu, Anhui province, Eastern China. The content characteristics, source identification, and risk assessment of heavy metals (Cd, Cu, Mn, Ni, Pb, and Zn) were studied based on the field investigation, sampling, indoor test, and statistical analysis. Results showed that the concentrations of Cd, Cu, Mn, Ni, Pb, and Zn showed different spatial variation and ranged from 0.48 to 1.84, 12.78 to 239.07, 287.14 to 491.96, 15.29 to 52.99, 13.28 to 68.82, and 28.83 to 184.79 mg/kg, respectively. Besides Mn, the contents of other metals have exceeded the local background value to a certain extent, and the higher concentrations recorded were found in the east of Bali channel. Source analyses indicated that Cd, Cu, Pb, and Zn were attributed to industrial emissions, vehicle exhaust pollution, and phosphate uses in agriculture, whereas Ni and Mn were mainly of natural origin. Among the six heavy metals, Cd posed the highest ecological risk with the proportion of 3.3% at a considerable level, 36.7% at a high level, and 60% at a very high level, Cu presented a low-to-moderate ecological risk, while others presented a relatively low risk in surface soils, suggesting that Cd and Cu, especially for Cd, should draw environmental concern. | 2022-12-18T19:18:23.612Z |
86,758,295 | {
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} | The hypothesis that predation pressure permits increased niche overlap among prey species is sustained by analysis of a model in which a predator population has been added to the three species "limiting similarity" model of MacArthur and Levins (1967). Also, it is predicted that there is a relation between the niche separation distances among prey and properties of the predators, and that if predation pressure is strong enough there is no limiting similarity among prey; i.e., complete niche overlap should be possible. | 2022-12-20T23:32:56.617Z |
6,733,389 | {
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} | In the past decade Unmanned Vehicles have become a topic of interest in many research organizations. Unmanned vehicles based systems are integrated to many applications in various areas ranging from military missions to wildfire detection. Recently, there has been a great interest to design collaborative systems of unmanned air vehicles (UAV) and unmanned ground vehicles (UGV). This paper proposes a new algorithm that can be used to calculate optimal UAV paths and UAV-UGV quantities to cover a target area. This algorithm is useful for patrolling systems based on the collaboration of unmanned air vehicles and unmanned ground vehicles. | 2022-12-27T18:48:25.049Z |
244,065,757 | {
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} | The article examines the reasons for exile to monastic prisons in the XIX century. In addition, attention is paid to the national history of correctional institutions. | 2022-01-27T08:21:53.208Z |
126,239,058 | {
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} | ABSTRACT A closed-form representation of the distribution function of the ratio of two linear combinations of Chi-squared variables is derived. The ratio is of the following form R = (X + aY)/(bY + Z), where X, Y, Z are independent Chi-square variables and a, b > 0. Two methods of obtaining the distribution function of this ratio are used. The exact density function of such a ratio is then obtained by differentiation. Two numerical examples are provided. | 2022-02-09T16:23:20.226Z |
233,173,936 | {
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} | Antithrombin is unique among serpin family protein protease inhibitors with respect to the major reactive center loop (RCL) and core conformational changes that mediate allosteric activation of its anticoagulant function by heparin. A critical role for expulsion of the RCL hinge from a native stabilizing interaction with the hydrophobic core in the activation mechanism has been proposed from reports that antithrombin variants that block this change through engineered disulfide bonds block activation. However, the sufficiency of core conformational changes for activation without expulsion of the RCL from the core is suggested by variants that are activated without the need for heparin and retain the native RCL-core interaction. To resolve these apparently conflicting findings, we engineered variants in which disulfides designed to block the RCL conformational change were combined with constitutively activating mutations. Our findings demonstrate that while a reversible constitutive activation can be engineered in variants that retain the native RCL-core interaction, engineered disulfides that lock the RCL native conformation can also block heparin allosteric activation. Such findings support a three-state allosteric activation model in which constitutive activating mutations stabilize an intermediate-activated state wherein core conformational changes and a major activation have occurred without the release of the RCL from the core but with a necessary repositioning of the RCL to allow productive engagement with an exosite. Rigid disulfide bonds that lock the RCL native conformation block heparin activation by preventing both RCL repositioning in the intermediate-activated state and the release of the RCL from the core in the fully activated state. | 2022-11-17T15:47:24.374Z |
26,380,703 | {
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} | The spatial distribution and concentration profiles of 39 vapor and particulate polycyclic aromatic hydrocarbons (PAHs) have been investigated in two Japanese industrial cities (Fuji and Shimizu; a summer and winter season in each). The concentrations of particulate PAHs in winter tended to be higher than those in the summer, but for vapor PAHs, this was not the case. Significant correlations (p < 0.01) were found between most of the PAH concentrations monitored in winter, suggesting the presence of common emission sources. To identify PAH spatial distributions and emission sources in the area, we created contour maps for PAHs monitored; this indicates that the distinctive local distributions correspond to the emission sources. PAH profiles based on benzo[e]pyrene (BeP) concentration, especially for certain relatively heavy molecular weight PAHs, showed differential behaviors among divided areas related to potential regional emission sources such as paper-making plants, power plants, and traffic. We conclude that the origins of atmospheric PAHs in the surveyed areas were dominated by not only traffic but also by stationary emission sources such as paper-making plants and power plants and that local distributions were dependent on the local wind direction. | 2022-12-19T23:36:10.818Z |
228,143,877 | {
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} | 近十年来,随着人们对遗传病、传染病及肿瘤的发生发展机制、诊治方法的研究越来越深入,分子病理学已成为病理学发展的重要方向.不论从基础病理研究还是临床病理诊断,以分子生物遗传学技术与传统病理学技术相结合的分子病理学技术得到了临床病理医师和病理科研人员的广泛应用.其方法种类也日趋成熟丰富.尤其在临床病理诊断和肿瘤分子靶向治疗中,依靠分子病理技术得出的结果数据不仅具有诊断作用,而且还为指导用药和预后判断提供了参考标准[1-2].目前,国内各大医院的病理科相继开展了分子病理检测项目,为临床诊治增添了新的病理学依据.如何设置分子病理实验室、并对其进行标准化管理,有效地利用实验室资源,确保实验室工作有序进行、为临床医师诊治疾病提供可靠准确的实验结果,亦成为病理科发展建设的重点。 | 2022-01-27T20:46:30.517Z |
240,522,164 | {
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This article analyzes the process of establishment and development of public diplomacy of the Slovak Republic. The author provides certain definitions of the term public diplomacy, as well as discusses the formation of public diplomacy of the Slovak Republic and its concept after declaring independence. Analysis is conducted on the development and implementation of public diplomacy of the Slovak Republic abroad at the present stage. The article consists of the three sections: the first explores the general concept of public diplomacy; the second analyzes the establishment and development of public diplomacy of the Slovak Republic; the third demonstrates the implementation of public diplomacy in the Slovak Republic in the current context. The problem of public diplomacy is currently relevant and subject to extensive analysis. With the course of time, public diplomacy has been playing a significant role in foreign policy of the Slovak Republic, and thus, a crucial factor in its international life. The author’s special contribution consists in examination of the materials of the Ministry of Foreign and European Affairs of the Slovak Republic. Methodological framework is comprised of systemic approach, as well as general and private scientific methods, such as analysis, synthesis, comparison, and historical method. The scientific novelty of this research lies in the comprehensive approach towards the analysis of public diplomacy in the Slovak Republic and its evolution.
| 2022-02-07T20:16:16.004Z |
93,857,630 | {
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"url": "https://www.osti.gov/biblio/5645495"
} | The MHD Heat and Seed Recovery Technology Project at Argonne National Laboratory is obtaining information for the design and operation of the steam plant downstream of the MHD channel-diffuser, and of the seed regeneration process. The project goal is to supply the engineering data required in the design of components for prototype and demonstration MHD facilities. The primary effort of the HSR Technology Project at Argonne is directed toward experimental investigations of critical problem areas, such as (1) corrosion and erosion of refractories and metal alloys; (2) NO/sub x/ behavior in the radiant boiler and secondary combustor; (3) radiant boiler design to meet the multiple requirements of steam generation, NO/sub x/ decomposition, and seed-slag separation; (4) effects of solid or liquid seed deposits on heat transfer and gas flow in the steam and air heaters; (5) formation, growth, and deposition of seed-slag particles; and (6) character of the combustion gas effluents. These investigations are performed primarily in a 2-MW test facility, the Argonne MHD Process Engineering Laboratory (AMPEL). Other project activities are related to studies of the thermochemistry of the seed-slag combustion gas system, and evaluation of seed regeneration processes. Progress is reported. | 2022-07-11T02:39:14.450Z |
22,891,515 | {
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} | Comparative information mining is an important research topic in the sentiment analysis community. A comparative sentence expresses at least one similarity or difference relation between two objects. For example, the comparative sentence “The space of car A is bigger than that of car B and car C” expresses two comparative relations and . This paper introduces conditional random fields model to extract Chinese comparative information and focuses on the task of element extraction from comparative sentences. We use the conditional random fields model to combine diverse lexical, syntactic and semantic features derived from the texts. Experiments show that the proposed method is competitive and domain-independent, with promising results. | 2022-09-09T06:37:20.594Z |
30,615,772 | {
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} | BACKGROUND
Congestive heart failure is associated with blood volume expansion caused by stimulation of the renin-aldosterone system and arginine vasopressin. The use of left ventricular assist devices as bridges to heart transplantation has improved the survival of patients during this critical period. In studying heart failure physiology on support devices, we hypothesized that improvement of cardiac function by a left ventricular assist device is associated with normalization of volume load secondary to normalization of its regulatory substances.
METHODS AND RESULTS
We studied 15 patients (13 men, 2 women: age 51 +/- 8 years) with end-stage heart failure who were cardiac transplant candidates eligible for HeartMate implantation. We measured plasma volume and plasma levels of atrial natriuretic peptide, aldosterone, renin, and arginine vasopressin sequentially before HeartMate implantation (baseline), after HeartMate implantation (weeks 4 and 8), and after transplantation. Baseline plasma volume was 123 +/- 20% of normal; it was 122 +/- 22% at week 4 and decreased to 115 +/- 14% at week 8. Atrial natriuretic peptide was 359 +/- 380 pg/mL at baseline, 245 +/- 175 pg/mL at week 4, and 151 +/- 66 pg/mL at week 8. Plasma aldosterone fell from 68 +/- 59 ng/dL at baseline to 17 +/- 16 ng/dL at week 4 (P < .05 versus baseline) and was 32 +/- 50 ng/dL at week 8. Plasma renin activity decreased from 80 +/- 88 ng/dL at baseline to 11 +/- 12 ng/dL at week 4 and was 16 +/- 38 ng/dL at week 8 (both P < .05 versus baseline). Arginine vasopressin fell from 5.0 +/- 4.8 fmol/mL at baseline to 1.1 +/- 0.7 fmol/mL at week 4 and 1.2+/-0.8 fmol/mL at week 8 (both P < .05 versus baseline).
CONCLUSIONS
The reduction of plasma renin activity, plasma aldosterone, and arginine vasopressin occurred earlier than the reduction of plasma volume and atrial natriuretic peptide after HeartMate implantation, possibly because of decreased pulmonary congestion and improved renal perfusion. The reduction of atrial natriuretic peptide cannot be responsible for the lack of adequate decrease of plasma volume; its reduction can be taken as a marker of improved cardiac pump function and decreased atrial stretch. | 2022-12-10T05:29:54.136Z |
7,734,412 | {
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"DOI": "10.1002/cav.1471",
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} | In this paper, we propose a new method to automatically extract keyframes from animation sequences. Our method can be applied equally to both skeletal and mesh animations. It uses animation saliency computed on the original data to help select the group of keyframes that can reconstruct the input animation with less perception error. For computational efficiency, we perform nonlinear dimension reduction using locally linear embedding and then carry out the optimal search in much lower‐dimensional space. With this approach, reconstruction of the animation from the extracted keyframes shows much better results as compared with earlier approaches. Copyright © 2012 John Wiley & Sons, Ltd. | 2022-12-14T17:22:59.468Z |
198,477,984 | {
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"DOI": "10.3390/BUILDINGS9070156",
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} | The use of textiles in architecture can cover a wide set of solutions and functions, spanning from buildings, towards geotechnical, aeronautic or automotive fields, etc. Special applications involve textiles in the health care or dressing scenarios. A multitude of other functions can then be found relatively for the use of textiles in building engineering and facades. As far as traditional facades or roofs composed of glass are taken into account, textiles offer a relevant number of potential uses that are specifically focused on energy, acoustic, insulation and even structural goals, in addition to pure architectural objectives. It is known that glass is relatively versatile, but has intrinsic needs and thermo-physical and mechanical features that require dedicated design methods, towards safe design purposes. Glass itself, in the form of constructional material, cannot be directly compared to other consolidated solutions for buildings. The same concept applies to textiles, and to their use to enhance other building components. Besides the key advantages deriving from the use of textiles in glass facades and envelopes—in the form of light, thermal or acoustic insulation, or energy efficiency—special care must be spent for specific structural requirements and performances. In some cases, textiles can in fact offer enhanced resistance to ordinary glass structures. In other conditions, textiles in combination with glass can ensure also enhanced acoustic and thermal performances. A multidisciplinary design approach able to properly fit several objectives should be considered. This paper aims at exploring the actual knowledge on glass textiles, with a focus on available tools and research trends, with careful consideration for structural glass facade applications. | 2022-12-17T11:00:01.732Z |
24,420,205 | {
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} | The objective of this study was to compare the sensitivity and specificity of a new method for self-sampling for high risk human papillomavirus (HPV) with direct sampling and liquid based cervical cytology. In Shanxi Province, China, 8,497 women (ages 27–56) underwent a self-sample for HPV using a conical-shaped brush placed into the upper vagina and rotated. Three to sixteen months later the women were screened with liquid-based cytology and direct HPV tests. Subjects with any abnormal test underwent colposcopy and multiple biopsies. Mean age was 40.9 years. 4.4 percent of subjects had ≥CIN II, 26% a positive self-sample and 24% a positive direct test for HPV. The sensitivity for detection of ≥CIN II was 87.5% for self-sampling, and 96.8% for the direct test (P < 0.001). The specificity was 77.2% for the self-sample and 79.7% for the direct test. With an abnormal Pap defined as ASCUS or greater the sensitivity of the Pap for the detection of ≥ CIN II was 88.3% and the specificity was 81.2%. We conclude that self-sampling for HPV is less sensitive for ≥ CIN II than the direct test, but similar to liquid based cytology. | 2022-12-18T01:36:07.785Z |
235,555,849 | {
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} | The city of Capanema - PA, developed along the banks of the Ouricuri River. In view of this, it is important to know the capacity of self-depuration of this water resource. The objective of this research was to analyze quantitatively and qualitatively the simulation of the self-depuration capacity of this lotic environment, and to propose two mitigating measures for the reduction of the impacts generated in the hydric body and improvements in the quality of the water. The method was deductive, quantiqualitative in scope and applied in nature. The data obtained and analyzed, for the three points, P1, P2 and P3, in the rainy period: for Rio Ouricuri were, DO: x = 0.26 mg/L; BOD5: x = 10 mg/L; flow: x = 1.80 m³/s; temperature: x = 26 oC, for the effluent ring: OD: x = 0.16 mg/L, BOD5: x = 300 mg/L; flow: 0.88 m³/s; temperature: x = 26 oC. In the dry period, for Ouricuri River: OD: x = 0.16 mg/L; BOD5: x = 10 mg/L; flow rate: x = 0.93 mg/L; and temperature: x = 25 oC; for the effluent washer: OD: x = 0.43 mg/L, BOD5: x = 300 mg/L, flow rate: x = 0.88 m³/s, and temperature: x = 27 °C. The values of DO, and BOD are compared with the CONAMA Resolution 357/05, and it was found that they are in non-compliance, therefore, the river is considered polluted for both potability and bathing. Therefore, it is necessary that the responsible bodies in the municipality use the data contained herein to develop mitigation measures for the recovery of the river. | 2022-02-07T21:15:52.642Z |
12,845,654 | {
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} | Here is a report on an inexpensive alternative for patients who cannot afford the more traditional prosthetic replacements. Utilizing composite resin and a titanium bar, this restoration can be accomplished in a single visit. | 2022-02-13T04:06:32.834Z |
249,559,847 | {
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"url": "https://jurnal.kwikkiangie.ac.id/index.php/JA/article/download/800/541"
} | The probability of an auditor found and reported a mistatement or an error due to fraud that occurs in a client's accounting system in perform the task called as audit quality. This study aims to determine the effect of competency, independency, professionalism, audit tenure and audit delay on audit quality. The research object consist of auditors who work in an active Public Accounting Firm (KAP) located in the DKI Jakarta area. The sampling technique used purposive sampling technique, obtained 85 auditor respondents from 12 active Public Accounting Firms listed in the KAP database published by the Ministry of Finance of the Republic of Indonesia in the DKI Jakarta area. The data analysis technique used is descriptive statistical analysis, data quality test, classical assumption test and hypothesis testing using SPSS Statistics 22. The results of the study conclude that there is sufficient evidence that the variables of competency, independency, professionalism and audit tenure have significant positive effect on audit quality. On the other hand, there is not enough evidence that the audit delay variable has a significant negative effect on audit quality.
Keywords: Competency, Independency, Professionalism, Audit Tenure, Audit Delay, Audit Quality.
References:
Ade Nahdiatul Hasanah, M. S. P. (2018). Pengaruh Ukuran Perusahaan, Audit Tenure Terhadap Kualitas Audit. Jurnal Akuntansi, 5(1), 11–21. Retrieved from https://akuntabilitasuinjkt.wordpress.com/tag/audit-tenure/
Agoes, S. (2018). Auditing (Edisi 5; E. S. Suharsi, Ed.). Jakarta Selatan: Salemba Empat.
Arens, A. A., Elder, R. J., & Beasley, M. S. (2017). Auditing and Assurance Services (Edisi 16). London: Pearson Education.
Ashton, R. H., Willingham, J. J., & Elliott, R. K. (1987). An empirical analysis of audit delay. Journal of Accounting Research, 275–292.
Bustami, A. (2013). Pengaruh Independensi, Akuntabilitas Dan Profesionalisme Auditor Terhadap
Kualitas Audit (Studi Empiris Pada Kantor Akuntan Publik di DKI Jakarta). 66(2012), 1–168.
CNN. (2019). Kemenkeu Beberkan Tiga Kelalaian Auditor Garuda Indonesia. Retrieved November20, 2020, from CNN Indonesia website https://www.cnnindonesia.com/ekonomi/20190628124946-92-407304/kemenkeu-beberkan-tiga- kelalaian-auditor-garuda-indonesia
Committee, A. F. A. S. (2000). SEC Auditor Independence Requirements. AAA Financial Accounting Standards Committee. Accounting Horizons, 15(4), 373–386.
Cooper, D. R., & Schindler, P. S. (2017). Metode Penelitian Bisnis, Edisi 12. Jakarta: Salemba Empat. DeAngelo, L. E. (1981). Auditor size and Audit Quality. Journal of Accounting and Economics, 3(3), 183–199.
Duff, A. (2004). Dimensions of Audit Quality (First; A. Rowe, Ed.). Great Britian: The Institute of Chartered Accountants of Scotland CA.
futri, S., & Juliarsa, G. (2014). Pengaruh Independensi, Profesionalisme, Tingkat Pendidikan, Etika Profesi, Pengalaman, Dan Kepuasan Kerja Auditor Terhadap Kualitas Audit Pada Kantor Akuntan Publik Di Bali. E-Jurnal Akuntansi, 8(1), 41–58.
Ghozali, I. (2016). Aplikasi Analisis Multivariate Dengan Program IBM SPSS 23 (Edisi 8). Semarang: Universitas Diponegoro.
Gunawan, L. D. (2012). Pengaruh Tingkat Independensi, Kompetensi, Obyektifitas, dan Integritas Auditor terhadap Kualitas Audit yang Dihasilkan Kantor Akuntan Publik di Surabaya. Jurnal Ilmiah Mahasiswa Akuntansi, 1(4), 44–48. Retrieved from http://journal.wima.ac.id/index.php/JIMA/article/view/245%5Cnhttp://jurnal.wima.ac.id/index.p hp/JIMA/article/view/245
Hall, R. H. (1968). Professionalization and bureaucratization. American Sociological Review, 92–104.
Herianti, E., & Suryani, A. (2016). Pengaruh Kualitas Auditor , Audit Delay dan Audit Tenure Terhadap Kualitas Audit Perbankan yang Terdaftar di BEI Periode 2012-2014. Prosiding Seminar Nasional INDOCOMPAC, 416–425.
Herry. (2017). Auditing Dan Asurans (Adipramono, Ed.). Jakarta: PT Grasindo. IAI. (2011). SA Seksi 220. Standar Auditing, (01), 1–3.
Idris, M. (2011). Pengaruh Profesionalisme, Karakteristik Personal Auditor Dan Batasan Waktu Audit Terhadap Kualitas Audit. E-Jurnal Akuntansi, 1–131.
Jensen, M. C., & Meckling, W. H. (1976). Theory Of The Firm: Managerial Behavior, Agency Costs And Ownership Structure. Journal of Financial Economics, 3(10), 305–360.
Kurniawan, S. L. (2019). Pengaruh Independensi, Pengalaman Audit, Etika Auditor, Komitmen Auditor dan Time Budget Pressure Terhadap Kualitas Audit (KAP Solo dan Yogyakarta ). 1–20.
Messier, W. F., Glover, S. M., & Prawitt, D. F. (2017). Auditing & Assurance Services. New York: McGraw Hill Education.
Pertiwi, N., & Agusti, R. (2013). Pengaruh Kompetensi, Independensi, Profesionalisme Terhadap Kualitas Audit (Studi Empiris Pada Kantor Akuntan Publik Se Sumatera). TEKUN: Jurnal Telaah Akuntansi Dan Bisnis, 8(1), 1–13.
Prabhawanti, P. P., & Widhiyani, N. L. S. (2018). Pengaruh Besaran Fee Audit dan Independensi Terhadap Kualitas Audit dan Etika Profesi Auditor Sebagai Moderasi. E-Jurnal Akuntansi,24, 2247.
Pratiwi, A. A. C., Suryandari, N. N. A., & Susandya, A. P. G. B. A. (2020). Pengaruh Profesionalisme, Independensi dan Kompetensi Auditor Terhadap Kualitas Audit Pada Kantor Akuntan Publik Di Provinsi Bali. Jurnal Kharisma, 21(1), 1–9.
Santhi, L. G. M. ., & Ratnadi, N. M. D. (2013). Independensi Auditor Sebagai Pemediasi Pengaruh Audit Fee Dan Time Budget Pressure Pada Kualitas Audit. Journal of Chemical Information and Modeling, 01(01), 1689–1699.
Sarwoko, I. (2014). Pengaruh Ukuran Kap Dan Masa Perikatan Audit Terhadap Penerapan Prosedur Audit Untuk Mendeteksi Risiko Kecurangan Dalam Laporan Keuangan, Serta Implikasinya Terhadap Kualitas Audit. Jurnal Akuntansi, XVIII(01), 1–20.
Sisna Armawan, I. P., & Wiratmaja, I. D. N. (2020). Pengaruh Pengalaman, Kompetensi, Independensi dan Fee Audit pada Kualitas Audit. E-Jurnal Akuntansi, 30(5), 1208.
Sugiyono. (2017). Metode Penelitian Kuantitatif Kualitatif dan R&D. Bandung: Alfabeta.
Sutani, D. (2017). Pengaruh Fee Audit, Audit Tenure, Audit Delay dan Komite Audit Terhadap Kualitas Audit (Studi Empiris pada Perusahaan Transportasi, Infrastruktur dan Ultilities yang terdaftar di Bursa Efek Indonesia Tahun 2014-2017). Al-Buhuts, 13(2), 127–145.
Tandiontong, M. (2016). Kualitas Audit dan Pengukurannya. Bandung: Alfabeta.
Teijlingen, E. R. Van, & Hundley, V. (2001). The Importance of Pilot Studies. Social Research Update, 2001(35), 4694–4699.
Tjun, T. L., Marpaung, E. I., & Setiawan, S. (2012). Pengaruh Kompetensi dan Independensi AuditorTerhadap Kualitas Audit. Jurnal Akuntansi, 4(1), 33–56.
Wardhani, A. A. I. T. W. (2018). Pengaruh Kompetensi, Akuntabilitas dan Independensi pada Kualitas Audit dengan Etika Auditor Sebagai Variabel Moderasi. E-Jurnal Akuntansi Universitas Udayana, 23(4), 1–29.
Werastuti, D. N. S. (2013). Pengaruh Auditor Client Tenure, Debt Default, Reputasi Auditor, Ukuran Klien dan Kondisi Keuangan Terhadap Kualitas Audit Melalui Opini Audit Going Concern. VOKASI Jurnal Riset Akuntansi, 2(1), 99–116.
Wiratama, W. J., & Budiartha, K. (2015). Pengaruh Independensi, Pengalaman Kerja, Due
Professional Care dan Akuntabilitas Terhadap Kualitas Audit. E-Jurnal Akuntansi, 91–106 | 2022-07-08T03:55:32.954Z |
205,095,290 | {
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} | Author Contributions: Dr Haider had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Concept and design: De Jager, Goralnick, McCarty, Hashmi, Haider. Acquisition, analysis, or interpretation of data: All authors. Drafting of the manuscript: De Jager, Goralnick, McCarty, Haider. Critical revision of the manuscript for important intellectual content: De Jager, Goralnick, McCarty, Hashmi, Jarman, Haider. Statistical analysis: Goralnick, McCarty, Hashmi, Jarman, Haider. Administrative, technical, or material support: De Jager, Goralnick, McCarty, Haider. Supervision: Goralnick, Haider. | 2022-09-06T13:09:32.040Z |
205,328,694 | {
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} | AIM AND OBJECTIVES
To investigate how spinal cord injured patients struggle with their rehabilitation and how they feel that the professionals influence this process.
BACKGROUND
Rehabilitation after a spinal cord injury is a long and arduous process during which the patient needs much support. Some patients lack adequate support from the professionals. This makes it pertinent to investigate the processes patients go through to get on with their lives and the influence professionals have.
DESIGN
A phenomenological-hermeneutic study with a narrative approach using Ricoeur's theory.
METHOD
A purposeful and consecutive sample of 12 newly injured, adult Danish-speaking patients previously living a normal life were observed 7-12 times and interviewed six or seven times over two years.
RESULTS
The patients regained meaning and got on with life through resolute fighting for a meaningful life. We found three patterns of fight; the patients fought with themselves together with the professionals (pattern I). If consensus about the goals and pathway broke down and was not re-established, this fight could turn into a fight against the professionals (pattern II). This would, in turn, cause the patients to fight against themselves. A third pattern (III) was that the patients turned away, either going their own way or suppressing themselves by adapting to the professionals' views. In either case, the patients would feel being left on their own.
CONCLUSION
When the patient and professionals agreed on the way forward, the patient experienced the professionals as supportive. However, if the patient's goals were not consistent with the professionals' views, the patient felt that the professionals withdrew their support.
RELEVANCE TO CLINICAL PRACTICE
If the professional were able to maintain consensus with the patient, they contributed to the patient's process of regaining meaning. | 2022-12-17T22:46:49.594Z |
145,234,934 | {
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} | This article draws on the conceptual link between power and causality to develop an account of the relational, discursive, and performative dimensions of power. Each proposed dimension of power is grounded in a different understanding of social causes: relational-realist, discursive-hermeneutic, and performative-pragmatic. For the purposes of empirical analysis, this dimensional schema crosscuts the classic sources of power typology developed by Michael Mann and others, thus rendering the conceptual apparatus for pursuing sociological research on power more complex and explanatorily effective. The schema is illustrated by an example from comparative-historical sociology: explaining the storming of the Bastille and its effects. A series of research questions for investigating the relative autonomy of performative power is proposed. Finally, the current schema is situated vis-a-vis classic sociological theories of power, including the arguments of Steven Lukes, Michel Foucault, and Pierre Bourdieu, among ot... | 2022-12-25T17:26:02.197Z |
172,567 | {
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} | Motivation: In silico prediction of drug-target interactions plays an important role toward identifying and developing new uses of existing or abandoned drugs. Network-based approaches have recently become a popular tool for discovering new drug-target interactions (DTIs). Unfortunately, most of these network-based approaches can only predict binary interactions between drugs and targets, and information about different types of interactions has not been well exploited for DTI prediction in previous studies. On the other hand, incorporating additional information about drug-target relationships or drug modes of action can improve prediction of DTIs. Furthermore, the predicted types of DTIs can broaden our understanding about the molecular basis of drug action. Results: We propose a first machine learning approach to integrate multiple types of DTIs and predict unknown drug-target relationships or drug modes of action. We cast the new DTI prediction problem into a two-layer graphical model, called restricted Boltzmann machine, and apply a practical learning algorithm to train our model and make predictions. Tests on two public databases show that our restricted Boltzmann machine model can effectively capture the latent features of a DTI network and achieve excellent performance on predicting different types of DTIs, with the area under precision-recall curve up to 89.6. In addition, we demonstrate that integrating multiple types of DTIs can significantly outperform other predictions either by simply mixing multiple types of interactions without distinction or using only a single interaction type. Further tests show that our approach can infer a high fraction of novel DTIs that has been validated by known experiments in the literature or other databases. These results indicate that our approach can have highly practical relevance to DTI prediction and drug repositioning, and hence advance the drug discovery process. Availability: Software and datasets are available on request. Contact: [email protected] Supplementary information: Supplementary data are available at Bioinformatics online. | 2022-12-31T19:14:26.248Z |
44,753,511 | {
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} | Head and neck cancer is one of the most common malignancies. Currently, it has a poor prognosis and significant mortality as the majority of malignancies present in later stages. Early diagnosis affords early intervention and the best chance of cure. However, the current gold standard for diagnosis largely depends on histopathology via an invasive procedure, tissue biopsy. The processing of biopsy material also inevitably leads to diagnostic delay and the possibility of taking an unrepresentative sample. Recently, there has been significantly increasing interest in the use of spectroscopy (e.g., fluorescence, elastic scattering, and Raman spectroscopy) and other optical systems to provide an early, real-time, non-invasive, and in situ diagnosis. Such diagnosis is based on the fact that the optical spectrum derived from any tissue reveals information about the histological and biochemical characteristics of that tissue. These optical systems have not only a role in cancer detection but also in treatment through guided biopsy, surgical margin assessment, and the monitoring of therapeutic drugs. However, our literature search is limited only to clinical diagnosis and only to the clinical trials published within recent 15 years (in 2000-2014). In this review, we will discuss and summarize the progress and new findings from recent clinical trials using these optical systems in the diagnosis of head and neck cancer. | 2022-03-16T10:25:55.790Z |
192,604,403 | {
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} | 4066 Background: This study evaluates the feasibility, safety and efficacy of a trimodality treatment, with surgery postponed after neoadjuvant chemotherapy (CT) and chemoradiotherapy (CRT), in LAGC. Methods: Patients (pts) with cT3-4 and/or N+ LAGC were eligible. Staging included endoscopic ultrasound, PET-CT and laparoscopy. Three cycles of EOX (Epirubicyn 50mg/m2,q21 days, Oxaliplatin 130mg/m2,q21 days, and Capecitabine 625mg/m2 bid, by continuous oral administration (c.a.), followed by IMRT with 45Gy/25 frs, concurrent Capecitabine 625mg/m2 bid c.a. and weekly Oxaliplatin 30mg/m2 for 5 wks, was planned. Early PET-CT was performed after the 2nd EOX cycle to assess response or disease progression. Restaging was repeated after CT and CRT. Surgery was planned 4-6 wks after CRT, 22 wks from the start of NEOX-RT. Pathologic complete response (pCR) was the primary endpoint. Results: From November 2008 to March 2016, 51 pts (5 G-E Junction, 17 Cardia, 15 Corpus, 14 Antrum) entered the study. The NEOX-RT program was completed in 46 pts (90%) who proceeded to surgery and are assessable. Grade 3-4 toxicity (NCI-CTC criteria v.3) occurred in 13/51 pts (25%) during EOX, including 1 toxic death, and 9.5% CT cycles required dose modification, resulting in a CT compliance of 90%. No pts had progression during CT. Persistent G2-G3 toxicity occurred in 32/46 pts (69%) during CRT. However, 41/46 pts (89%) received the planned 45Gy with Capecitabine at dose ≥75% and 4-5 cycles of weekly Oxaliplatin in 52% pts. Curative resection (R0) rate was 89%; 4 pts (8.7%) had peritoneal carcinomatosis at surgery done after a median of 23 wks. pCR was reported in 9/46 pts (19.6%). Major postop complications occurred in 5 pts (11%). At median f-up of 62 mos (23-109), 5-yr OS and DFS in all and pCR pts were 58%, 100% and 51%, 75%, respectively. Conclusions: This trimodality program was feasible and safe. Most pts completed the planned treatment. The pCR rate of 19.6% was remarkable and met the hypothesis of pCR = 20%. A high R0 rate was also reported and delayed surgery didn’t increase complications. The notable survival rates are available to be compared with ongoing phase III trials. Clinical trial information: 2008-002715-40. | 2022-06-25T02:57:54.502Z |
159,946,710 | {
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} | In the first half of the nineteenth century, the male-dominated temperance movement, through its association of alcoholism and unrestrained violence, first focused the attention of Americans on wife beating and murder. Temperance societies, in printed speeches and tracts, stimulated government concern and generated official reports, which in turn created both a need and a market for temperance fiction. All drove home the same terrifying points. Although Samuel Cary, Cincinnati's major temperance figure, might have been perceptive in suggesting that "scenes of drunkenness, debauchery, crime, poverty and destitution become familiar and we come to regard them as a matter of course," at least the literature left few people able to plead ignorance of the dangers faced in the home (quoted in Dannenbaum 1984, 173). Alcohol destroyed man's self control, weakened moral influences, and unleashed antisocial passions. "Intemperance brings into operation the worst passions of human nature. Anger, malice, envy, revenge... | 2022-09-06T07:37:46.139Z |
97,222,732 | {
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} | The oxidation of hydrogen on platinum has been studied using a microcalorimetric technique. The reaction takes place by two mechanisms depending on whether the surface is in an oxidised or reduced state. On the reduced surface, hydrogen is dissociatively adsorbed and competes with adsorbed molecular oxygen for adsorption sites. The reaction rate is higher on the oxidised surface where hydrogen molecules are weakly adsorbed and react with strongly adsorbed oxygen. | 2022-09-23T05:01:54.360Z |
237,867,049 | {
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"url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/basr.12234"
} | Funding information Bundesministerium für Bildung und Forschung (German Federal Ministry for Education and Research), Grant/Award Number: 02L14A041 Abstract As occupational health management (OHM) and work health promotion (WHP) become increasingly prominent in companies worldwide, little is known about consumers' attitudes towards work health-related issues. Do consumers consider the health of employees in German companies to be important? Do German companies consider consumers to be relevant stakeholders in voluntary occupational health (OH) and well-being activities? In the first of two qualitative interview studies, German consumers were asked which actors they consider to be responsible in OH contexts and whether or not they prefer OH-related product attributes to other socially desirable ones. During a second qualitative interview study with representatives from German companies, suppliers, institutions, and organizations concerned with voluntary and legally mandatory OH, participants were asked about their expectations regarding whether or not consumers are interested in such OH activities. Both studies highlight the difference between the consumers' perspective on OH issues and responsibilities on the one hand and what companies and stakeholders believe consumers think about OH issues DOI: 10.1111/basr.12234 | 2022-12-07T14:52:18.508Z |
86,134,359 | {
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} | Summary The purpose of this work was to study the landscape characteristics of the forests and woodlands in the Snowdonia National Park, North Wales (UK). Using a geographical information system, several landscape indices were calculated for the broadleaves, conifers, mixed high forest and scrub vegetation categories. A total of 3967 woodland fragments, covering an area of 216 664 ha, were analysed in terms of their area, density, degree of isolation and shape in order to understand their spatial distribution and connectivity. The analyses showed that the broadleaved habitat is dissected into a great number of patches, irregular in shape and with a mean patch size of <4 ha. Fragments of mixed forest had similar sizes and were more isolated across the landscape. Scrub contained many small and similar-sized patches, more regular in shape. When these habitats were analysed using an edge width of 100 m, ~99 per cent of the total scrub area was found to lie within edge habitat. Conifer forest presented as a very clumped habitat containing larger patches with higher variability in size. Objective GIS simulation techniques for ameliorating this fragmentation of the broadleaves, mixed forest and scrub were demonstrated using two sites in the Park. Simulations using these techniques show that (1) conversion of conifers to broadleaves, (2) reforestation of agricultural land between woodland fragments or (3) creating buffer zones around existing woodland would considerably increase the area of interior or core habitat and connectivity between the presently fragmented native woodland. | 2022-12-07T17:29:13.243Z |
26,055,087 | {
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"url": "http://deepblue.lib.umich.edu/bitstream/2027.42/154540/1/fsb2009013004.pdf"
} | The flavoprotein thioredoxin reductase catalyzes the reduction of the small redox protein thioredoxin by NADPH. Thioredoxin reductase contains a redox active disulfide and is a member of the pyridine nucleotide‐disulfide oxidoreductase family of flavoenzymes that includes lipoamide dehydrogenase, glutathione reductase, trypanothione reductase, mercuric reductase, and NADH peroxidase. The structure of thioredoxin reductase has recently been determined from X‐ray crystallographic data. In this paper, we attempt to correlate the structure with a considerable body of mechanistic data and to arrive at a mechanism consistent with both. The path of reducing equivalents in catalysis by glutathione reductase and lipoamide dehydrogenase is clear. To envisage the path of reducing equivalents in catalysis by thioredoxin reductase, a conformational change is required in which the NADPH domain rotates relative to the FAD domain. The rotation moves the nascent dithiol from its observed position adjacent to the re surface of the flavin ring system toward the protein surface for dithiol‐disulfide interchange with the protein substrate thioredoxin and moves the nicotinamide ring of NADPH adjacent to the flavin ring for efficient hydride transfer. Reverse rotation allows reduction of the redox active disulfide by the reduced flavin. This requires that the enzyme pass through a ternary complex; the kinetic evidence for such a complex is discussed.—Williams, G. H., Jr. Mechanism and structure of thioredoxin reductase from Escherichia coli. FASEB J. 9, 1267‐1276 (1995) | 2022-12-12T08:18:25.252Z |
235,546,516 | {
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"DOI": "10.14210/COTB.V12.P232-239",
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} | The increase in the number of users of the Smart TVs has been veryfast: just between 2016 and 2017, there has been an expansion ofmore than 7 million users. At the same time, considering the globalestimates referring to the increase of longevity, it can be predicteda gradual increment of elderly people utilizing these devices in thecoming years, which highlights the importance of perfecting theirquality of use. In this context, the objective of the present study isto evaluate what are the main challenges elderly people face whileusing Smart TVs, focusing on a specific application, known as NETNow. To conduct this study, the focus was on the quality of useof communicability, analysed through the application of two evaluationmethods: the Semiotic Inspection Method, applied by oneevaluator, and the Communicability Evaluation Method, applied tosix participants aged between 60 and 80 years. It has been observedthat both methods indicated problems related to different communicabilitybreakdowns, emphasizing the importance of this kindof evaluation in order to improve the quality of use of interactivesystems. | 2022-12-16T15:45:05.244Z |
24,915,020 | {
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"url": "https://www.int-res.com/articles/dao2014/110/d110p143.pdf"
} | Previously reported in Australia, New Zealand, and more recently in Europe, the protistan parasite Bonamia exitiosa was also reported in the mid-Atlantic region of the USA after causing serious mortalities there in the Asian oyster Crassostrea ariakensis. At the time, this oyster was being considered for introduction, and the potential consequences of introducing this species were being assessed using field and laboratory studies. B. exitiosa emerged as the most serious disease threat for this oyster species, especially under warm euhaline conditions and for oysters <50 mm in size. To better evaluate how quickly this parasite may be able to spread among C. ariakensis, we investigated B. exitiosa transmission and incidence in C. ariakensis. During a first trial, potential direct transmission of B. exitiosa was evaluated by cohabitating infected C. ariakensis with uninfected C. ariakensis under in vivo quarantine conditions. In a second experiment, B. exitiosa incidence was estimated in situ by determining its prevalence in C. ariakensis deployed in an enzootic area after 4, 7, 14, 21 and 28 d of exposure. Results suggest that under warm euhaline conditions B. exitiosa can be transmitted among C. ariakensis without requiring any other parasite source and that parasite incidence may be at least as high as 40% after only 4 d exposure to an enzootic area. These results underscored the severity of the bonamiasis disease threat to C. ariakensis and provided further evidence that efforts to build an aquaculture industry based on C. ariakensis in the eastern USA might have been thwarted by parasitic disease. | 2022-12-20T13:45:30.660Z |
7,273,987 | {
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} | For three-dimensional photonic crystals, made either by top-down microfabrication or by bottom-up self-assembly approaches, to comply with the stringent requirements of optical telecommunication applications, their degree of structural perfection and optical quality must meet an exceptionally high standard. Only with such superior quality photonic crystals can their unique optical properties be harnessed in optical devices and circuits constructed from micrometer-sized optical components. In this paper, we present a new strategy for making silica colloidal crystal films with a sufficiently high level of structural perfection and optical quality to make it competitive as a practical route to photonic crystal optical components. The attainment of this goal takes due cognizance of three key synergistic factors in the film formation process. The first recognizes the necessity to prepare high-quality silica spheres, which are highly monodisperse, with a polydispersity index significantly better than 2%, and the second recognizes that the population of spheres must be devoid of even the smallest fraction of substantially smaller or larger spheres or sphere doublets. The latter turns out to have a minimal effect on the polydispersity index, and yet a major detrimental effect on the overall structural order of the film. The third concerns the film-forming method itself, which necessitated the development of a novel process founded upon isothermal heating evaporation-induced self-assembly (IHEISA) of spheres on a planar substrate. This new method has several advantages over previously reported ones. It is able to deposit very high-quality silica colloidal crystal film rapidly over large areas, with a controlled thickness and without any restrictions on sphere sizes. | 2022-12-21T09:38:05.008Z |
191,427,815 | {
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"DOI": "10.1093/gao/9781884446054.article.t051172",
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} | The Lindisfarne Gospels, a manuscript produced in the Northumbrian island monastery of Lindisfarne at the end of the seventh century in honour of Saint Cuthbert, is one of the world's foremost masterpieces of book painting. It is a precious relic of early Christianity in England, and one of the nation's greatest treasures. This is the first ever book to make the glories of the Lindisfarne Gospels accessible to a wide public. All the essential illuminated pages are reproduced impeccably in colour from an entirely new and accurate set of photographs. | 2022-09-15T02:50:13.766Z |
13,682,270 | {
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"status": "GOLD",
"url": "https://www.spandidos-publications.com/10.3892/ol.2018.8146/download"
} | Malignant lymphoma of the uterine cervix is exceedingly rare and is difficult to diagnose by cervical cytology. The current study presents a case of malignant lymphoma of the uterine cervix that was presumptively diagnosed by cervical cancer screening in which the patient had no clinical symptoms. The anterior lip of the uterine cervix was occupied by a macroscopic hemorrhagic tumor. The obtained tumor cells exhibited typical cytological features of malignant lymphoma and were positive for CD20. The final diagnosis was diffuse large B cell lymphoma of the uterine cervix, stage IIEA (Ann Arbor classification). The patient received 6 courses of R-CHOP chemotherapy and achieved complete remission. Despite its rarity, the possibility of malignant lymphoma should be considered while screening for cervical cancers using Pap smears. The Pap test screening may be useful for the early diagnosis of malignant lymphoma of the uterine cervix in certain cases. By reaching a rapid and accurate diagnosis, immediate treatment may be initiated and surgery may be avoided. | 2022-09-17T05:55:08.077Z |
213,054,132 | {
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} | Justificativa: A hérnia diafragmática é uma complicação incomum nos procedimentos cirúrgicos torácicos e abdominais, mas importante pois submete o paciente à uma nova intervenção e põe a vida do mesmo em risco. Caso: Paciente masculino submetido a nefrectomia total após necrose por litíase renal. No pós-operatório apresentou sintomas dispépticos; o estudo de imagem revelou hérnia diafragmática esquerda com protusão total do estômago na região torácica. Discussão: A hérnia diafragmática é definida como a evisceração transdiafragmática de conteúdo abdominal no tórax, afetando mais frequentemente o estômago. Podem ser classificadas em congênitas e adquiridas, prevalecendo a Bochdalek como a principal herniação congênita. A hérnia diafragmática iatrogênica é uma complicação rara, existindo poucos relatos na literatura. O diagnóstico é estabelecido pelo exame de Tomografia Computadorizada que evidencia a protusão da víscera na cavidade torácica. O tratamento de escolha é cirúrgico. | 2022-12-15T03:10:14.455Z |
28,515,207 | {
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} | In depth-based 3D video, the view synthesis distortion (VSD), is generally measured by modeling the effect of texture and depth errors separately. With such a development, it has been referred that the VSD changes monotonically with respect to to both the texture and depth distortions. In this paper, we find that the VSD does not always change monotonically with them by both theoretical analysis and experimental test, when the effect of the texture and depth errors is considered together. Specifically, first, we prove that the VSD is non-monotonic with the texture distortion. That is, the VSD increases with the increasing texture distortion at higher distortion range but conversely decreases with it at lower range. It is different from the general scenario that only considering the effect of the texture errors. We also analytically depict their relationship with low computational cost and identify the turning point at which the change of the VSD is converted. Second, we confirm that the VSD is always monotonic with the depth distortion, which is consistent with the general scenario that only considering the effect of the depth errors. The non-monotonicity property of the VSD can be utilized to improve the viewing performance of 3D video in relevant applications, since a minimal value of the VSD exists at the turning point. We conduct two applications for this purpose. First, it is used to generate the synthesis view of minimal distortion, which achieves 0.51-dB gain of PSNR on average for the tested scenarios. Second, it is used for lossy compression of texture videos in 3D video, which reduces the coding rate by 24% on average for the tested scenarios, meanwhile, keeps the VSD not increased simultaneously. | 2022-12-11T02:18:45.430Z |
143,422,640 | {
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"DOI": "10.1063/1.5071447",
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"url": "https://aip.scitation.org/doi/pdf/10.1063/1.5071447"
} | In this work, we present a commercial CMOS (Complementary Metal Oxide Semiconductor) Raspberry Pi camera implemented as a Near-Infrared detector for both spatial and temporal characterization of femtosecond pulses delivered from a femtosecond Erbium Doped Fiber laser (fs-EDFL) @ 1.55 µm, based on the Two Photon Absorption (TPA) process. The capacity of the device was assessed by measuring the spatial beam profile of the fs-EDFL and comparing the experimental results with the theoretical Fresnel diffraction pattern. We also demonstrate the potential of the CMOS Raspberry Pi camera as a wavefront sensor through its a nonlinear response in a Shack-Hartmann array and for the temporal characterization of the femtosecond pulses delivered from the fs-EDFL through TPA Intensity autocorrelation measurements. The direct pulse detection and measurement, through the nonlinear response with a CMOS, is proposed as a novel and affordable high-resolution and high-sensitivity alternative to costly detectors such as CCDs, wavefront sensors and beam profilers @ 1.55 µm. The measured fluence threshold, down to 17.5 µJ/cm2, and pJ/pulse energy response represents the lowest reported values applied as a beam profiler and a TPA Shack-Hartmann wavefront sensor, to our knowledge. | 2022-12-21T20:02:22.800Z |
147,383,671 | {
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"DOI": "10.2307/1354156",
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} | n order to introduce and integrate, within the space of this paper, several "new objects of knowledge" which cannot meaningfully exist within the discursive vrai (truth) of our present "fundamental arrangements of knowledge"' nor within the analogic of its "(ethico-) theoretical foundations,"2 I shall make use of a series of epigraphs placed at different points of the argument. Their function will be to project the possibility of a "demonic observer" ground3 outside the consolidated field of meanings of our present analogic, a ground in which these "new objects of knowledge" can find their efficient criterion/ | 2022-12-28T20:48:47.160Z |
96,952,378 | {
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"DOI": "10.14341/2072-0351-6010",
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"url": "https://doi.org/10.14341/2072-0351-6010"
} | Aim. To measure concentration of carbohydrate-containing biopolymers in liver and gastric mucosa of rats with alloxan diabetes and varying stressresistance. Materials and methods. The ?open field? test was used to allocate the animals to 2 groups (stress-sensitive and stress-resistant). Insulin-dependentdiabetes was induced by a single s/c injection of alloxan tetrahydrate (170 mg/kg). Total glycosaminoglycanes and gyaluronidase activity were measuredin gastric mucosa. Results. Concentration of glycosaminoglycanes (sialic acids) in the liver increased in animals of both groups and reached a maximum on day 30. Conclusion. Metabolism of sialoglycoproteins in gastric mucosa was dominated by catabolic processes most intense on day 45 after induction of experimentaldiabetes | 2022-04-01T01:40:26.140Z |
243,415,072 | {
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"DOI": "10.31219/osf.io/k3vey",
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} | This study demonstrates the combinations of multiple causal factors that formulate a startup’s strategy to successfully “exit”, namely “recipes for a successful exit,” in the clean- and hard-tech sector. We identify seven key causal factors (i.e., causal conditions) that impact startup success, including commercial readiness, investor interactions, favorable industry, non-financial support, straightforward development path, experienced team, and visibility to investors. We also investigate the combinations of selective causal conditions that can provide further synergetic impact. We conduct the fuzzy-set qualitative comparative analysis (fsQCA) on seven US clean and hard-tech startups that exited between 2005 and 2016. The successful companies all demonstrate distinctive characteristics based on three general categories (1) robust ecosystem; (2) heavy-lifting team; or (3) external opportunity. Across these three categories, commercial readiness and strong investor interactions are necessary conditions for all exit cases. But there are important differences that drive success in each category, such as the interaction with non-financial support (in the robust ecosystem case), experienced team (in the heavy-lifting team case), and favorable industry (in the external opportunity case). Our findings are meant to support entrepreneurs in reaching an exit by optimizing the given internal and external circumstances, and policymakers to build a robust ecosystem that can increase the success rate of the clean- and hardtech development. | 2022-07-10T04:12:32.802Z |
146,611,401 | {
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"DOI": "10.36322/jksc.v1i38.5218",
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"url": "https://journal.uokufa.edu.iq/index.php/ksc/article/download/5218/4830"
} | شهدت المدن العربية خلال العقود الماضية تطورا عمرانيا ملحوظا وزيادة سكانية كبيرة نتيجة الزيادةالطبيعية للسكان وزيادة في حجم الهجرة السكانية ، وقد انعكس هذا التطور تلقائيا على الجوانب الاقتصادية، والثقافية، والاجتماعية في الكثير من هذه البلدان ، وبالمقابل فقد كان لهذا التطور العمراني والانفتاح الاقتصادي، والاجتماعي، والثقافي بعض الاثار السلبية على الوضع الامني والاجتماعي في تلك المدن ، حيث تعد الجريمة واحدة من اهم هذه الاثار السلبية، وهي احدى المظاهر المهمة التي تمت دراستها على المستوى العالمي ، واجتهد المهتمون من مخططين ومعماريين للسيطرة على هذه الظاهرة لغرض تحقيق الامن والامان ولا سيما في المجتمعات السكنية لتأثير تلك الظاهرة على سلوك الانسان فيها واحساسه بالأمن ، وقد شخص البحث مشكلة عدم شمولية المعرفة العلمية المتوفرة حول دور واهمية التخطيط والتصميم في تحسين البيئة السكنية للحد من الجريمة . ومن هذا المنطلق تهدف هذه الدراسة الى مناقشة دور واهمية التخطيط والتصميم العمراني في تحسين مستوى الامن والسلامة وابراز اهم المعايير التخطيطية والتصميمية التي تساهم في توفير بيئة خارجية بيئة سكنية أفضل للسكان.Arab cities witnessed during the last decades remarkable urban development and large population increase as a result of natural population growth and an increase in the size of migration of the population, This development has been reflected automatically on aspects of economic, cultural, and social development in many of these countries, by contrast, it was for this urban development and economic openness, and social, cultural and some negative effects on the security situation and social in those cities, where it is crime and one of the most important of these negative effects, one of the manifestations of the task that has study the global level, and strove interested of planners and architects to control this phenomenon for the purpose of safety and security, particularly in communities residential impact of this phenomenon on human behaviour and sense of security, has anyone Find the problem of lack of comprehensive scientific knowledge available about the role and the importance of planning and design to improve the residential environment to reduce crime. With this in mind aim of this study is to discuss the role and the importance of urban planning and design to improve the level of safety and security and to highlight the most important planning and design standards that contribute to the provision of better housing external environment for the population. | 2022-08-20T18:40:06.881Z |
109,612,170 | {
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"url": "https://ntlrepository.blob.core.windows.net/lib/25000/25500/25536/DOT-HS-805-620.pdf"
} | A Drunk Driver Detection Guide was developed and tested at a sample of 10 law enforcement agencies at locations throughout the United States. The test was designed to provide both longitudinal and cross-sectional analyses of several measures likely to reflect the impact and utility of using the Guide, and to verify the values contained in the Guide. The DWI experienced police officers who used the Guide expressed doubts about its value in improving their own DWI enforcement ability. However, they considered the Guide to be valuable for increasing patrol sensitivity to important cues, training new patrol officers, preparing DWI arrest reports, and supporting court testimony. | 2022-09-06T03:57:35.557Z |
229,508,718 | {
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"DOI": "10.47240/revistadaesg.v35i74.1045",
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"url": "https://revista.esg.br/index.php/revistadaesg/article/download/1045/925"
} | In 2004, Brazil submitted a claim to extend the limits of its continental shelf beyond200 nautical miles to the UN Commission on the Limits of the Continental Shelf. Thisarticle analyzes the normative evolution on continental shelf, and the implications ofBrazil’s claim, with attention to the security and defense in the South Atlantic. | 2022-01-27T09:01:16.465Z |
194,376,806 | {
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"DOI": "10.3917/aj.501.0075",
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} | The Zak Gallery, located in the Saint-Germain-des-Pres district, was founded by Jadwiga/Hedwige Kon Zak, wife and widow of the Polish painter Eugeniusz Zak. In the Paris of the interwar period, the gallery quickly became an important place of artistic encounters. During the German occupation, her personal collection of artworks and that of her gallery were looted by Vichy officials. In 1943, her arrest with her son in the Nice area led Edwige Zak to the Birkenau camp where she was murdered. The article focuses on what can be said today of Edwige Zak's working life. The dynamism of the art gallery is clear to the researcher. However, it remains difficult to identify the personality of Edwige Zak, who was, in her time, an appreciated art dealer. | 2022-02-08T08:15:39.996Z |
122,046,744 | {
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"DOI": "10.1063/1.1683523",
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} | The PPA standard hydrogen target system was tested for a catastrophic failure of the target flask. Two tests were performed. In the second test, the size of the vacuum housing surrounding the target flask was reduced. The resulting pressures, effect on the Mylar windows, and a single phase analysis of the gas flow are discussed. | 2022-02-09T19:37:12.881Z |
224,639,836 | {
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} | 조경은 지속가능한 국토·도시 환경 구축을 위해 필수불가결한 전문 분야이다. 조경산업은 국민들의 건강과 복지증진, 도시 활성화와 주거 환경 개선, 일자리 창출 등과 밀접한 관련이 있다. 조경의 다양한 공익적 가치에도 불구하고, 조경서비스의 질적 제고를 위해 전제되어야 할 조경산업의 성장동력은 정체되어 있다. 사업 규모의 영세화, 안정적 생산·유통 체계 부재, 협업 체계 미흡, 신기술 도입 어려움 등의 복합적 문제를 드러내고 있다. 2015년 「조경진흥법」 제정을 통해 조경산업의 집적을 통한 활성화를 지원하기 위해 조경진흥시설과 조경진흥단지 제도를 마련하였으나, 구체적인 운용 방안이 부재한 실정이다. 본 연구는 조경 분야 종사자와 전문가를 대상으로 한 인식조사를 통해 조경분야 발전을 위해 도입된 조경진흥시설과 조경진흥단지 제도의 활성화 방안을 마련하고자 하였다. 주요 연구결과는 다음과 같다. 첫째, 조경분야 종사자들과 전문가들은 조경 산업 진흥을 위한 정책 및 사업의 필요성을 매우 높게 인식하고 있다. 둘째, 조경진흥시설에 적합한 산업 유형은 설계, 유지·관리, 시공 분야가 선정되었다. 조경진흥단지에 적합한 산업 유형은 조경수와 조경시설물 생산 및 유통 분야가 선정되었다. 셋째, 조경진흥시설 지정을 통해 얻게 되는 기대효과로는 ‘네트워크 확대를 통한 사업기회 증가’, 조경진흥단지 지정을 통해 얻게 되는 기대효과로는 ‘각종 정보 공유 활성화’가 높게 평가되었다. 넷째, 조경진흥시설 지정기준 중에서는 ‘지자체 조경 산업 규모와 육성 역량’이, 조경진흥단지 지정기준 중에서는 ‘사업추진계획의 실현가능성’이 가장 중요한 것으로 나타났다. 다섯째, 조경진흥시설 제도 활성화를 위해 필요한 지원방안으로는 ‘세제 혜택 및 부담금 면제’, 조경진흥단지의 경우에는 ‘유지·관리비 지원’이 중요한 것으로 나타났다. | 2022-07-10T04:49:48.950Z |
220,420,831 | {
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} | the Decoy Pool farm, whereon some sixty or seventy years ago a decoy existed in the low meadows bordering the stream which flows from Tickenham to Clevedon. These meadows are often flooded during the winter months. The decoy, however, has long been abandoned, not haying been worked, it is believed, since 1820. The reader who may ascend Glastonbury Tor, and view the immense tract of wild land extending' north-west of Glastonbury towards the sea coast, will readily comprehend how attractive such a country must at one time have been to wildfowl. At the beginning of the century this great flat was still partially uncultivated, and subject in winter to frequent floods which gave it almost the appearance of a sea. It embraced some fifteen square miles of marsh and wet reed-grown meadows. The corners of the square might be taken as Wells, Langport, Uphill, and Lilstock, extending from near the foot of the Mendips almost to the Quantock hills. No wonder that wildfowl formerly abounded here, and that the owners of decoys in SomersetsWre at one time found them a source of considerable profit. | 2022-07-10T05:57:29.991Z |
248,784,173 | {
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} | The aim of this study is to identify the impact of a sea-land breeze circulation on the ventilation of air masses over the Mediterranean Tunisian coast (Boukornine area) during the summer period. Our results show the Mediterranean Sea has an important effect on the chemical characteristics of atmospheric aerosols by the advection of particles from the sea to the coastal site. Indeed, the daytime sea breeze as well the nighttime land breeze limit the ventilation of air masses by the redistribution of aerosols. Besides, it was found that higher concentrations of sodium, chlorine and sulfur over the examined area are associated with the sea-land breeze recirculation while the crustal constituents stay practically constant with some fluctuations due to local effect. The contribution of sea-breeze in Boukornine area was more important than those recorded in other sites in Tunisia. This study proves the high influence of topography which increases the effect of sea-breeze. | 2022-08-26T23:20:31.551Z |
245,916,477 | {
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} | Abstract This paper presents a methodology that permits to automate binary classification using the minimum possible number of attributes. In this methodology, the success of the binary prediction does not lie in the accuracy of an algorithm but in the evaluation metrics, which give information about the goodness of fit; which is an important factor when the data batch is unbalanced. The proposed methodology assesses the possible biases in identifying one algorithm as the best performer when considering the goodness of fit of an algorithm through evaluation metrics. The dimension of data has been reduced through the cumulative explained variance. Then, the performance of six machine learning classification models has been compared through Matthew correlation coefficient (MCC), area under curve – receiver operating characteristic (ROC-AUC), and area under curve – precision-recall (AUC-PR). The results show graphically and numerically how the evaluation metrics interfere with the most optimal outcome of an algorithm. The algorithms with the best performance in terms of evaluation metrics have been random forest and gradient boosting. In the imbalanced datasets, MCC has provided better prediction results than ROC-AUC or AUC-PR. The proposed methodology is adapted to the case of bankruptcy prediction. | 2022-09-07T10:53:24.589Z |
34,432,000 | {
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} | nature of neuralgia may at times attack the ovary, an organ vell supplied with nerves.' If so, it is reasonable to treat such a condition in the same way as neuralgia elsewhere. If drugs have failed, then operate. The injection of alcohol would hardly be recommended for ovarian pain, but the nerve supply, or a considerable part of it, if not all, may be cut off by simply dividing the suspensory ligament of the ovary. This, of course, means division of the ovarian artery and vein too, but the ovary will still have a sufficient blood supply to keep up its nourishment, and, that being so, ovulation and endocrine secretion should not be interfered with, unless the division of its nerve supply should so far impair these functions, which is not likely. This treatment would particularly apply if there were only one remaining ovary in a patient who had not reached the menopause. The pain must be relieved in some way, and the ovary must be spared if possible. On the left side the division of the ligament may serve to straighten out the pelvic colon and thus help the flow of contents. No claim to originality is made here for the idea of dividing the ovarian nerve supply, but the suggestion seems a practical and reasonable one, and therefore I emphasize it. I should like, in conclusion, to stress the two points brought forward early in this paper: 1. Diagnose neurasthenia last of all, after excluding all likely causes of pelvic pain. 2. In cases of pelvic pain make it a rule to examine first of all without an anaesthetic, even if such is neoessary for a full diagnosis afterwards. | 2022-09-10T18:47:44.618Z |
29,311,636 | {
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} | A screening of a range of common laboratory antibiotics for inhibition of the hammerhead ribozyme has shown that in addition to certain aminoglycosides (most notably neomycin B) the tetracyclines are also effective inhibitors, with chlorotetracycline being more effective than tetracycline. Inhibition by chlorotetracycline is not as strong as that by neomycin B but is more complicated, with at least two binding sites apparent. As with hammerhead inhibition by neomycin B, chlorotetracycline inhibition can be overcome by raising the concentration of the Mg2+ ion cofactor. We find that around six Mg2+ ions will displace neomycin B, compared with twelve for chlorotetracycline. Inhibition observed in the presence of mixtures of neomycin B and chlorotetracycline is consistent with separate binding sites on the hammerhead for these two classes of antibiotic. Under certain conditions of the mixing order and low concentration of chlorotetracycline, enhancement of single-turnover hammerhead cleavage by up to 20% is observed, with higher concentrations of antibiotic being inhibitory. We have also found that the presence of 2.5% (v/v) DMSO causes a 30% enhancement of the single-turnover cleavage. These results thus extend the range of known inhibitors of hammerhead cleavage, and also demonstrate how the cleavage can be accelerated. | 2022-09-14T04:23:21.941Z |
18,237,195 | {
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} | Acute respiratory distress syndrome is a devastating disease that causes substantial morbidity and mortality. Mechanical ventilation can worsen lung injury, whereas ventilatory strategies that reduce lung stretch, resulting in a “permissive” hypercapnic acidosis (HCA), improve outcome. HCA directly reduces nonsepsis-induced lung injury in preclinical models and, therefore, has therapeutic potential in these patients. These beneficial effects are mediated via inhibition of the host immune response, particularly cytokine signaling, phagocyte function, and the adaptive immune response. Of concern, these immunosuppressive effects of HCA may hinder the host response to microbial infection. Recent studies suggest that HCA is protective in the earlier phases of bacterial pneumonia-induced sepsis but may worsen injury in the setting of prolonged lung sepsis. In contrast, HCA is protective in preclinical models of early and prolonged systemic sepsis. Buffering of the HCA is not beneficial and may worsen pneumonia-induced injury. | 2022-12-17T05:21:30.725Z |
232,143,041 | {
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"DOI": "10.1021/acs.langmuir.0c02858",
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"license": null,
"status": "GREEN",
"url": "https://ses.library.usyd.edu.au/bitstream/2123/27548/1/Peppou-Chapman2020.pdf"
} | Lubricant-infused surfaces (LIS) have emerged as an innovative way to combat several modern challenges such as biofouling, ice formation, and surface drag. The favorable properties of LIS are dependent on the presence and distribution of a lubricant layer coating the underlying substrate. Unfortunately, this layer is not indefinitely stable and depletes due to external forces. Here, we study how an air/water interface depletes the lubricant from LIS as a function of lubricant wettability on the substrate by varying the chemistry of both the lubricant and the substrate. The lubricants were chosen to represent some of those most commonly used in the literature (silicone oil, perfluoropolyethers, and mineral oil). We use an optical Wilhelmy plate tensiometer to measure the contact angle of the air/water interface on the LIS in situ as the sample is driven through the air/water interface and contact angle hysteresis as a qualitative measure of lubricant depletion. This data is augmented with ex situ quantitative mapping of lubricant thickness using atomic force microscopy (AFM) meniscus force measurements. We find that a thick layer of excess lubricant is always removed in just one dip, regardless of wettability, and that lubricants that do not spread fully on the substrate deplete faster due to their dewetting into droplets. We also find that lubricants that spread onto the air/water interface are more susceptible to depletion. Finally, we investigate the effect of repeated immersions on the properties of liquidlike poly(dimethylsiloxane) (PDMS) chains tethered to glass and find that dynamic contact angles on these surfaces remain constant over several dips and therefore their low hysteresis is unlikely due to unbound polymer. | 2022-12-17T06:47:58.504Z |
24,400,725 | {
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"DOI": "10.4049/jimmunol.1601318",
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"license": null,
"status": "BRONZE",
"url": "https://www.jimmunol.org/content/jimmunol/198/3/999.full.pdf"
} | Immune cell activation and differentiation occurs concurrently with metabolic reprogramming. This ensures that activated cells generate the energy and substrates necessary to perform their specified function. Likewise, the metabolic programs among different cells of the immune system vary. By targeting different metabolic pathways, these differences allow for selective regulation of immune responses. Further, the relative susceptibility of cells to a metabolic inhibitor is dictated by their metabolic demands; cellular selectivity is based on demand. Therefore, where differences exist in metabolic pathways between healthy and pathogenic cells, there is opportunity for selective regulation with agents lacking intrinsic specificity. There are now a host of studies demonstrating how inhibitors of metabolism (e.g., glycolysis, glutamine metabolism, and fatty acid oxidation) can regulate immune responses and treat immune-mediated pathogenesis. In this brief review we detail how inhibitors of metabolism can be employed to regulate immune responses in both autoimmunity and transplantation. | 2022-12-17T10:13:34.130Z |
219,172,692 | {
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"DOI": "10.1177/1753466620929225",
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"license": "CCBYNC",
"status": "GOLD",
"url": "https://doi.org/10.1177/1753466620929225"
} | Background: Talaromyces marneffei, also named Penicillium marneffei, is an opportunistic pathogen that can cause systemic or limited infection in human beings. This infection is especially common in human immunodeficiency virus (HIV)-infected hosts; however, it has also been recently reported in HIV-negative hosts. Here, we report a very rarely seen case of T. marneffei pulmonary infection in a non-HIV-infected patient with signal transducer and activator of transcription 3 (STAT3) mutation. Case presentation: A 34-year-old woman was admitted to our hospital for uncontrollable nonproductive cough and dyspnea with exercise. She had been immunocompromised since infancy. Computerized tomography scan showed multiple ground glass opacities with multiple bullae in both lungs. Next generation sequencing (NGS) of the bronchoalveolar lavage fluid identified T. marneffei nucleotide sequences. Culture of bronchoscopy specimens further verified the results. The patient was HIV negative, and blood gene detection indicated STAT3 mutation. To date, following the application of itraconazole, the patient has recovered satisfactorily. Conclusion: In clinical practice, T. marneffei infection among HIV-negative individuals is relatively rare, and we found that patients who are congenitally immunocompromised due to STAT3 mutation may be potential hosts. Early diagnosis and timely treatment are expected to improve the prognosis of T. marneffei infection. NGS is a powerful technique that may play an important role in this progress. The reviews of this paper are available via the supplemental material section. | 2022-12-30T00:35:46.101Z |
245,067,654 | {
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"DOI": "10.37410/emerg.2021.3.04",
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"license": "CCBYNC",
"status": "GOLD",
"url": "https://doi.org/10.37410/emerg.2021.3.04"
} | The present paper deals with the problem of building up a 100 MW hydro pumped storage power plant (HPSPP) in the Republic of Moldova. The main technical characteristics of the plant have been determined (quantity of water to be pumped, the upper and the lower reservoir dimensions, etc.). Several possible plant locations were investigated and finally an indicative assessment of the plant economic feasibility has been carried out. | 2022-02-07T20:03:22.710Z |
70,685,097 | {
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"DOI": "10.1001/ARCHDERM.1976.01630330077023",
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} | To the Editor.— "Sebaceous nevus" is good English but not customary nomenclature. "Nevus sebaceus" is good Latin, and it is also customary nomen-clature. "Nevus sebaceous" is both Latin and English! Author, reviewer, editor, manuscript editor, or proofreader should have spotted this error somewhere along the line and corrected it before it got into the February issue of theArchives. It's just as unacceptable as lichen "planous" or lupus "erythematous" would be. | 2022-02-11T11:21:24.377Z |
3,498,180 | {
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"DOI": "10.1109/ICOEI.2017.8300888",
"MAG": "2791302434",
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} | Code Analyzer is a software metrics analysis tool which is used to find KLOC, LOC, Number of comment lines and white spaces, All the metrics which are mentioned above are calculated for the whole project, for the classes and functions of the project separately. This tool can be used for various programming languages like C, C++, Java, HTML, and Assemble. We can generate report files in various formats like text, HTML, CSV. Linked List is a data structure which is used to store data using pointers, In this paper, correlation coefficient can be obtained by using some linked list programs like Generic list versions and other linked list programs stacks, queues, binary tree. Using the Pearson and specimen we are going to find the correlation coefficient among those programs, Finally, we have are showing the relation between the codes of metrics data for various linked list programs. | 2022-02-13T12:37:49.577Z |
52,050,830 | {
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"DOI": "10.1109/CONTROLO.2018.8439735",
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} | The fast mobility of HSR leads to its channel state's more intense and frequent fluctuations, making it difficult to transmit real-time streaming media. In this paper, we propose an adaptive bitrate control algorithm for real-time streaming media transmission in HSR networks. At the receiver, we detect network congestion based on the one-way queuing delay and estimate the bandwidth according to the buffer state. To improve the sensitivity to the change of HSR network state, the bandwidth is estimated frequently. However, only the effective estimation results are fed back. The sender adjusts the bitrate according to the feedback bandwidth and the loss-based estimation bandwidth. Experiments and practical tests show that the proposed algorithm can effectively avoid unnecessary rate switching, reduce the video stalling and improve the bandwidth utilization of real-time streaming media transmission on HSR occasions. | 2022-07-09T09:38:38.358Z |
161,567,915 | {
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"ArXiv": null,
"DOI": "10.17851/2358-9787.23.1.15-36",
"MAG": "1543897464",
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} | A troca de cartas entre os modernistas brasileiros fez circular textos ineditos e debates teoricos sobre a producao literaria moderna,produzindo redes de sociabilidade letrada e consensos esteticos e politicos. Este artigo tem por objetivo o estudo do tema lirismo discutido na correspondencia de Mario de Andrade com alguns de seus interlocutores durante os anos de 1920. | 2022-07-31T04:53:26.242Z |
144,769,962 | {
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"DOI": "10.1002/TESJ.121",
"MAG": "2062108678",
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} | “English” classrooms in U.S. institutions of higher education are not linguistically homogeneous. It is not logical, ethical, or realistic to designate “standard” English as the only discourse acceptable for the writing classroom. This praxis-oriented article chronicles a U.S. composition instructor's process of re-envisioning a formerly monolingualist, unidirectional composition curriculum through a lens that acknowledges and celebrates the World Englishes paradigm. The revised curriculum is driven by the translingual approach to composition pedagogy, which understands hybridity and fluidity as the norms of language acquisition, usage, and development, and focuses on one of the approach's practical pedagogical applications: the code-meshing strategy of writing. The article provides an overview of the author's institutional context and offers observations about how the traditional monolingualist conceptual framework has marginalized and alienated students whose language practices do not fit within it. The article explains how the translingual approach to composition pedagogy, and specifically the teaching of code-meshing as a viable communicative tool, has contributed to positive changes in students' self-perceptions as language users in and out of the classroom. The article concludes with informed reflections, from the vantage point of a composition and TESOL teacher-scholar, on further ways that the World Englishes ethos might manifest in the paradigm of U.S. composition theory and instruction. | 2022-09-02T13:13:38.162Z |
160,850,792 | {
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"DOI": "10.4324/9781315843582",
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} | Part 1 Biographical and historical context: chronological tales family life - Lady Wilde and Mrs Oscar Wilde Ireland homosexuality the myth of Wilde. Part 2 Aesthetic and political philosophy: lectures journalism "The Woman's World", "The Soul of Man Under Socialism" critical dialogues theatre practice and innovation. Part 3 Critical survey: poetry - "Poems" (1881), "The Ballad of Reading Gaol" short fiction - "The Happy Prince", "The House of Pomegranates" aesthetic criticism aesthetic prose - "The Fisherman and His Soul" newspaper fiction - "Lord Arthur Savile's Crime and Other Stories" "The Picture of Dorian Gray", Salome, "Salome" and symbolist theatre the social comedies - "Lady Windermere's Fan", "A Woman of No Importance", "An Ideal Husband", "The Importance of Being Earnest" letters - "De Profundis" on prison reform. Part 4 Reference section: Wilde and his circle a Wilde gazetteer short glossary of critical terms further reading. | 2022-09-04T12:33:39.624Z |
7,914,677 | {
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"DOI": "10.1117/12.257353",
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} | In this study, the problem of multiplexing VBR and ABR traffic is considered. VBR is uncontrollable, while ABR is provided the remaining service capacity in a controllable fashion. While in a given state, the VBR source is supposed to transmit at a fixed rate; the VBR time scale is then defined in terms of the time constant associated with the rate of change of the rate of the VBR source. ABR sources are assumed to be at some distance from the multiplexing network node; the network speed defines the network time scale which determines the distance (in network slots) between the ABR sources and the node. Finally, the minimum tolerable ABR rate (or the speed at which the ABR source can generate data units to be cellized) define the source time scale. While it is known that the increased network transmission speed (decreased network time scale) reduces the effectiveness of feed-back based adaptive rate control mechanisms due to the increased bandwidth propagation delay product, the positive impact of the VBR and ABR time scales has not been considered in the past. In this work a tractable analytical model is considered and the impact of the three time scales is investigated. | 2022-09-14T04:34:03.265Z |
252,720,025 | {
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"DOI": "10.1109/MERCon55799.2022.9906288",
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} | Sri Lanka is frequently subjected to disasters caused by adverse natural shocks and climatic stresses. Climate change which is accelerated by Green House Gases is a main cause behind the more frequent and intense disasters. Hence, the construction industry is now heading towards Green Buildings as one of the sustainable aspects. Since the involvement in the green building industry in Sri Lanka as well, it has emphasized the importance of incorporating disaster resilience indicators into Green Building Rating Tools (GBRTs) to ensure that green buildings can withstand adverse natural shocks and climatic stresses while maintaining their long-term survivability. There have been various disputes over the concepts “disaster resilience” and “sustainable development,” which have impeded implementation. Therefore, in this research, a multicriteria decision-making tool, the Stepwise Weight Assessment Ratio Analysis (SWARA) method was used to identify the overall impact of the integration of disaster resilience indicators into a green building framework. It was intended to capture different perspectives of decision makers on each possible disaster resilience aspect that can be integrated into a GBRT related to the Sri Lankan context. The most suitable resilience indicators were selected from the GBRTs and related studies and used in the evaluation. They were assessed for their significance in enhancing disaster resilience as well as the sustainability of green buildings. The results have shown that risk avoidance related indicators can enhance the disaster resilience of the building while increasing the sustainability. Conversely, disaster resilience indicators like improved structural and architectural aspects, and excessive use of hazard-resilient and more robust materials can reduce the overall sustainability of a green building. | 2022-10-06T18:08:56.968Z |
6,034,663 | {
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"DOI": "10.1107/S1600536807046922",
"MAG": "2227217665",
"PubMedCentral": "2915087"
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} | The title compound, [Cu(C11H11NO5)(H2O)]n, was obtained by the reaction of Cu(NO3)2 and the homochiral organic ligand (S)-N-(2-hydroxybenzyl)-l-aspartic acid (S-H3sasp). The CuII ion has a distorted square-pyramidal geometry and is coordinated by one N atom and three O atoms from the organic ligand and one O atom from a water molecule. The carboxyl O atoms of the ligands bridge the Cu atoms to form an infinite one-dimensional zigzag chain. Intermolecular hydrogen bonds link these chains into a two-dimensional arrangement. | 2022-12-13T20:58:06.040Z |
25,001,481 | {
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"DOI": "10.1185/03007995.2011.586332",
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} | Abstract Objective: For chronic pain treatment many health care authorities consider morphine to be the reference standard for strategic decisions in pain therapy. Although morphine's effectiveness is clear and its cost is low, it's unclear whether morphine should remain the first choice or reference treatment. Research design and methods: We performed a systematic review to evaluate the evidence available to support the position of morphine as the reference standard for step III opioids based on efficacy and tolerability outcomes. Results: The search yielded 5675 titles and 56 studies were included. Considerable heterogeneity precluded pair-wise meta-analysis on change of pain intensity and no difference between morphine and other opioids were found for tolerability outcomes. The network meta-analysis showed no statistically significant difference in change of pain intensity between morphine and oxycodone, methadone and oxymorphone. Compared to morphine, patients using buprenorphine are more likely to discontinue treatment due to lack of effect (OR 2.32, 95% CI 1.37 to 3.95). Patients using methadone are more likely to discontinue due to adverse events (OR 3.09, 95% CI 1.14 to 8.36), whereas this risk is decreased for patients using fentanyl (OR 0.29, 95% CI 0.17 to 0.50) or buprenorphine (OR 0.30, 95% CI 0.16 to 0.53). The most important limitation of this review is that the included studies are heterogeneous with regard to study population and intervention, which may affect the pooled effect estimates. The main strength is that we only included parallel RCTs, the strongest design for intervention studies. Conclusions: The current evidence is moderate, both in respect to the number of directly comparative studies and in the quality of reporting of these studies. No clear superiority in efficacy and tolerability of morphine over other opioids was found in pair-wise and network analyses. Based on these results, a justification for the placement of morphine as the reference standard for the treatment of severe chronic pain cannot be supported. | 2022-12-17T22:44:50.141Z |
733,869 | {
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"DOI": "10.1109/ISIT.2007.4557581",
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} | Improved upper and lower bounds on the capacity of wireless optical intensity channels under non-negativity and average optical power constraints are derived. We consider intensity modulated/direct detection (IM/DD) channels with pulse amplitude modulation (PAM). Utilizing the signal space geometry and a sphere packing argument, an upper bound is derived. Compared to previous work, the derived upper bound is tighter at low signal-to-noise ratios. In addition, a lower bound is derived based on source entropy maximization over discrete distributions. The proposed distribution provides a tighter lower bound compared to previous continuous distributions. The derived bounds asymptotically describe the capacity of PAM optical intensity channels at both low and high SNR. | 2022-12-18T12:56:21.191Z |
28,466,899 | {
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"ArXiv": null,
"DOI": "10.5772/INTECHOPEN.84398",
"MAG": "2936294038",
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} | Non-bacterial thrombotic endocarditis or also called verrucous endocarditis or Libman-Sacks endocarditis or marantic endocarditis is a rare entity, still unknown physiopathology, which is characterized by the formation of sterile vegetations at the valvular structures. These vegetations of platelet aggregates and fibrin are sterile by definition, so for its definitive diagnosis, it is essential to rule out an infectious endocarditis. It is mainly diagnosed by echocardiography in patients with neoplasms or systemic autoimmune diseases. Its main complication is the formation of multi-systemic embolisms, preferably at the brain level, so anticoagulation will be fundamental in the treatment and evolution of non-bacterial thrombotic endocarditis. | 2022-12-19T07:01:45.577Z |
52,934,270 | {
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"DOI": "10.23919/CHICC.2018.8483607",
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} | Multi-convolution neural networks-based deep learning model in combination with multimodal data for emotion understanding is proposed, in which facial expression and body gesture are used to achieve emotional states recognition for emotion understanding. It aims to understand coexistence multimodal information in human-robot interaction by using multi-convolution neural networks, where multilayer convolutions are connected in series and multiple networks are executed in parallel. Moreover, when optimizing the weights of deep neural network by traditional method, it is easy to fall into poor local optimal. To address this problem, a hybrid genetic algorithm with stochastic gradient descent is developed, which has the capacity of inherent implicit parallelism and better global optimization of genetic algorithm so that it can adaptively find the better weights of the network. And in order to speed up the convergence of the proposal, the weights optimized by stochastic gradient descent will be taken as a chromosome of genetic algorithms initial population, and it also can be used as a priori knowledge. To verify the effectiveness of the proposal, experiments on benchmark database of spontaneous emotion expressions are developed, and experimental results show that the proposal outperforms the state-of-the-art methods. Meanwhile, the preliminary application experiments are also carried out and the results indicate that the proposal can be extended to human-robot interaction. | 2022-12-21T04:45:42.503Z |
227,156,580 | {
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"DOI": "10.4149/neo_2020_200924N1018",
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} | Cancer-associated fibroblasts (CAFs) are the major constituents of the tumor microenvironment and promote cancer development via tumor-stromal interactions. The alteration of microRNA (miRNA) expression in fibroblasts can induce the phenotype conversion between normal fibroblasts and CAFs in certain tumor types. However, the mechanisms underlying phenotype conversion of fibroblasts in colorectal cancer (CRC) are largely unknown. Our study focuses on the role of miR-1246 in fibroblasts-CRC cells interaction. In this study, CCD-18Co colorectal fibroblasts were cultured in the conditioned medium (CM) derived from CRC cells to obtain the CAF phenotype. We found that the miR-1246 expression was upregulated in CAF-like fibroblasts compared with normal fibroblasts. miR-1246 secreted by cancer cells could be utilized by neighboring fibroblasts for CAF reprogramming. On the other hand, following secretion by CAF-like fibroblasts, miR-1246 was delivered into CRC cells and promoted cell migration via the activation of the Wnt/β-catenin signaling in CRC cells. Furthermore, high miR-1246 expression in CRC tissues was negatively associated with disease-free survival (DFS) for CRC patients. Taken together, our results reveal that miR-1246 can shuttle between CRC cells and fibroblasts. This study also indicates that targeting miR-1246 or blocking its transport from CAFs to CRC cells might represent a novel therapeutic approach in CRC treatment. | 2022-12-27T16:16:11.036Z |
171,845,822 | {
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"DOI": "10.6093/978-88-6887-041-6",
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} | [English]:Diffractions. 1994: Philosophy put to test by Psychoanalysis, namely a changing over the method, better to say a style, of the philosophical discourse which “takes care” of other discourses, coming to aid or to annexe them, just because felt/perceived as deficient from the epistemological point of view, as they are no more than empirical knowledges, and thus in need of a “second foundation”.Beyond this canon, (it is) the experience of the proof of diffraction, with and within the thought itself, which means a mutual “de-construction and re-construction” of knowledges which assay themselves beyond any foolish and pretentious sovereignism.
Diffractions. 2018: Psychoanalysis between Kultur and Civilisation, namely the whole of the cultural products; the social patterns; the political and institutional options; the whole of the values and ideologies that shapes the Kultur itself, diffracted by the psychoanalytical stream, beyond any childish “gentry” of Kultur on Civilisation.
/ [Italiano]: Diffrazioni. 1994: la filosofia alla prova della psicoanalisi, ovvero ribaltare il metodo, in realta uno stile, del discorso filosofico che “si prende cura” di altri discorsi, o andando in loro soccorso, o praticandone l’annessione, perche ritenuti, in quanto saperi empirici, carenti dal punto di vista epistemologico e bisognosi dunque di una “ri-fondazione”.Oltre questo canone, fare esperienza, nel pensiero e con il pensiero, della prova della diffrazione, ovvero di una ‘scomposizione-ricomposizione’ reciproca dei saperi che si saggiano, aldila di ogni stupido e presuntuoso sovranismo!
Diffrazioni. 2018: la psicoanalisi fra Kultur e civilizzazione, ovvero l’insieme dei prodotti culturali, le configurazioni societarie, le opzioni politico-istituzionali, il mondo dei valori e delle ideologie che formano la sfera della Kultur, diffratti dal ‘discorso’ psicoanalitico, aldila di ogni infantile “nobilta” della Kultur sulla Civilizzazione. | 2022-02-08T16:36:46.140Z |
201,640,750 | {
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"DOI": "10.2514/6.2014-1808",
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} | In this paper we present Robust Commanding as a new method that mission planning systems can implement to improve the reaction of the planning system to unsuccessful commanding. This method can be used to improve upon flexibility and reaction time of the mission planning while maintaining a safe commanding concept that avoids gaps in the mission timeline. The prerequisites are highlighted and the method is presented and exemplified on the basis of commanding low-earth orbiting satellites. The necessary commanding interfaces are discussed and an outlook for application of this method to future satellite missions is given. | 2022-08-28T00:08:17.732Z |
121,738,471 | {
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"DOI": "10.1119/1.880509",
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} | This article recounts the author’s experience using wind chimes to teach the scientific method including significant figures, experimental error, types of variation, peer review of results, seeking empirical relationships within data, and testing the relations found. | 2022-02-09T19:51:51.322Z |
155,206,546 | {
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"DOI": "10.5465/AMBPP.1989.4977789",
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} | Acquisitive growth strategies absorb managerial energy and lead to increased leverage, greater diversification and larger size. Because of these effects, managers tend to emphasize short-term performance and become risk averse. Analysis of 191 mergers showed that acquisitive growth, leverage, diversification and size were negatively related to relative R&D intensity. | 2022-09-11T09:01:12.285Z |
94,115,052 | {
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"DOI": "10.1063/1.436729",
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} | Multiphoton resonance ionization (MPRI) bands of I2 vapor have been examined in the 360–600 nm region. A band system with T0 =48 426±4 cm−1 and ωe=254±1 cm−1 is assigned to a two‐photon resonant intermediate state involved in either three‐ or four‐photon ionization. Polarization measurements establish that the transition is either 1g or 2g←0g. Comparison to the Dalby system (2d), 5146 cm−1 to higher energy allows a more detailed interpretation of the excited states of both systems: 2g (2Π3/2g) nsσg and 1g (2Π1/2g) nsσg, respectively. Excitation into the visible B←X absorption band between 500 and 600 nm leads to a dense set of MPRI lines. An intense system in this region with T0 =35 762±4 cm−1 and ωe=104±1 cm−1 is assigned to a two‐photon resonant intermediate state with polarization measurements establishing it as 0g. It is further interpreted as arising from the two‐electron promotion 0g→σu, πu→σu. A striking feature of the MPRI spectra of I2 is the near absence of lines corresponding to the normal opti... | 2022-09-12T09:39:32.945Z |
145,256,954 | {
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"DOI": "10.1111/J.1467-6443.2009.01349.X",
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"status": null,
"url": null
} | This paper seeks to provide a new approach to analysing the crucial period of the building of the South African state between the Boer War and 1924. Drawing on the sociology of Michael Mann, it argues that the construction of networks of military power was of central and partly autonomous importance in giving shape to the new state. It goes on to contend that this generated a legal order which was in many ways shaped by practices which derived from martial law. The paper also asserts that these questions of military power and martial law need to be analysed within a framework which does not limit itself to the boundaries of the South African state itself, but is placed within the wider context of the British Empire and the southern African region. A biographical exploration the role of Jan Smuts as the key leader is used to focus the paper's study of this process of state-making. | 2022-09-13T06:46:19.735Z |
74,855,926 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.2329/PERIO.35.404",
"MAG": "2313220023",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | 歯科臨床医10名の協力を得て, 保険診療上I型で歯周治療を行った患者20名, II型で行った患者20名について調査を行った。患者群は, 年齢, 男女比, 病型, メンテナンス期間共にほぼ同じ構成を示すように配慮した。本調査用に作成した診査用紙およびX線写真から, オレリーのプラークコントロールレコード, 歯周ポケットの深さの変化 (各歯の最深部), 動揺度の変化, プロービング時の出血部位数の変化, 歯周治療開始前の歯槽骨吸収の程度 (口腔内を6分割し, 各分画において骨吸収度の程度を評価する) について検討し, さらに, I型とII型に分ける際の術者の選択基準を加味したところ, I型ではやや重症の患者を治療し, II型ではこれより軽症の患者を治療する傾向が見られたが, 同程度の治療効果が得られた。以上のことから保険診療上のI型の歯周治療は有用であり, 今後一般臨床医の間にも普及することが望まれる。 | 2022-05-31T15:32:13.257Z |
56,147,987 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1021/acs.chemrestox.8b00169",
"MAG": "2905192569",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Epoxy resin monomers (ERMs) are used as building blocks for thermosetting polymers in applications where strong, flexible, and lightweight materials are required. Most epoxy resins are polymers of diglycidyl ether of bisphenol A (DGEBA). It is highly allergenic and causes occupational allergic contact dermatitis and contact allergy in the general population. Thus, measures to prevent exposure by protective clothing and education are not enough. This work describes a continuation of our research aiming at reducing the skin-sensitizing potency of ERMs while maintaining the ability to form polymers. Alternative ERMs were designed and synthesized whereafter the sensitizing potency was determined using the murine local lymph node assay (LLNA). The reactivity of the diepoxides toward a nucleophilic peptide was investigated, and the differences in reactivity explained using computational studies. The diepoxides were reacted with triethylenetetramine, and the formed polymers were tested for technical applicability using thermogravimetric analysis. We had previously shown that the absence of an oxygen atom in the side chains or removal of aromaticity reduced the sensitizing potency compared to that of DGEBA. Thus, a cycloaliphatic analogue 1 of DGEBA without ether oxygen in the side chains was considered promising and was synthesized. As predicted, the sensitizing potency was considerably reduced (10 times) compared to that of DGEBA. However, the technical properties of the polymer of this compound were not considered sufficient. More polar aromatic analogues were investigated, but they could not compete with our previously described ERMs regarding polymerization properties and with 1 regarding low skin sensitization properties. Development of alternative epoxy materials is a delicate balance between allergenic activity and polymerization properties. Tuning of structural properties together with investigation of polymerization conditions combined with skin sensitization studies should be used in industrial research and development. ERM 1 could be used as a lead compound for further studies of aliphatic ERMs. | 2022-12-05T14:41:23.997Z |
7,933,301 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1145/301618.301641",
"MAG": "2070880808",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | A hierarchical module system is an effective tool for structuring large programs. Strictly hierarchical module systems impose an acyclic ordering on import dependencies among program units. This can impede modular programming by forcing mutually-dependent components to be consolidated into a single module. Recently there have been several proposals for module systems that admit cyclic dependencies, but it is not clear how these proposals relate to one another, nor how one might integrate them into an expressive module system such as that of ML.To address this question we provide a type-theoretic analysis of the notion of a recursive module in the context of a "phase-distinction" formalism for higher-order module systems. We extend this calculus with a recursive module mechanism and a new form of signature, called a recursively dependent signature, to support the definition of recursive modules. These extensions are justified by an interpretation in terms of more primitive language constructs. This interpretation may also serve as a guide for implementation. | 2022-12-09T00:01:07.198Z |
41,021,166 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.1093/SW/SWU057",
"MAG": "2099651184",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Prior research has focused on the relationship between parenthood and psychological well-being, with mixed results. Some studies have also addressed potential gender differences in this relationship, again yielding varied findings. One reason may be methodological choices pursued in these studies, including the lack of focus on combined parental roles (for example, biological parent and stepparent). The authors used data from the National Longitudinal Survey of Youth, 1979 (N = 6,276) and multinomial treatment models to address how combined roles influence depressive symptoms in mothers and fathers. Further, they explored potential gender differences. Their results indicated that having multiple parental roles is negatively associated with psychological well-being for both men and women, whereas childlessness is more negative for women, and specific parental role combinations affect mothers and fathers differently. Within the context of changing family structure in the United States, these results have important implications for social workers and other mental health professionals-particularly with regard to screening for depression among parents, who are less likely to seek mental health counseling than childless adults. | 2022-12-16T20:32:10.891Z |
147,298,209 | {
"externalids": {
"ACL": null,
"ArXiv": null,
"DOI": "10.5748/9788599693117-12CONTECSI/PS-2504",
"MAG": "2311634574",
"PubMedCentral": null
},
"license": null,
"status": null,
"url": null
} | Este estudo objetivou analisar a relacao entre as motivacoes, as habilidades e competencias do controller na percepcao de alunos de pos-graduacao em controladoria . Realizou-se uma pesquisa descritiva, de levantamento e com abordagem quantitativa. Os resultados do estudo indicaram que quanto maior for a perspectiva de aumento salarial, maior sera a visao ampla e critica das operacoes e a capacidade de implementar novas ideias e projetos e, menor sera a responsabilidade por conhecimentos de financas, contabilidade geral, de custos, habilidades de lideranca e trabalho em equipe e, pro atividade. Contudo, quanto menor for a perspectiva de melhorias na carreira e a satisfacao profissional, maior sera a visao ampla e critica das operacoes e capacidade para implantacao de novas ideias e projetos e menores serao as responsabilidades por conhecimentos de financas, contabilidade geral, de custos, habilidades de lideranca e trabalho em equipe e pro atividade. | 2022-01-23T03:17:15.474Z |
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