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stringlengths 57
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stringclasses 125
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dict |
|---|---|---|---|
fifteen rats were trained to discriminate between the tryptamine hallucinogen psilocybin ( 4-phosphoryloxy-n , n-dimethyltryptamine ; 1.0 mg/kg ) and saline in a two-lever choice task . | NA | {
"id": "C0041248",
"name": "tryptamine",
"pos": [
54,
64
]
} | {
"id": "C0027183",
"name": "dimethyltryptamine",
"pos": [
113,
131
]
} |
ethylketazocine and dextromethorphan produced responding primarily on the saline-appropriate lever , whereas codeine , cyclazocine , dextrorphan , and ketamine resulted in responding that was , on the average , intermediate between that appropriate for pentobarbital and that appropriate for saline . | NA | {
"id": "C0079314",
"name": "ethylketazocine",
"pos": [
0,
15
]
} | {
"id": "C0010526",
"name": "cyclazocine",
"pos": [
119,
130
]
} |
the effects of morphine , ketocyclazocine , cyclazocine , and skf-10,047 were tested alone and in conjunction with naltrexone or naloxone , in rats responding under a multiple fixed-interval 3-min schedule of food presentation . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
115,
125
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
129,
137
]
} |
all of the drugs ( except naltrexone and naloxone ) decreased average rates of responding maintained by the unpunished component in a dose-dependent manner . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
26,
36
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
41,
49
]
} |
morphine , ketocyclazocine , cyclazocine , and skf-10,047 increased responding that was suppressed by electric shock , and these increases were antagonized by naltrexone and naloxone . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
159,
169
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
174,
182
]
} |
when the volume of distribution of the labels was corrected , by subtracting fetal weight from maternal body weight , the red cell , plasma and blood volumes were all significantly greater in the pregnant rabbits ( p less than 0.02 ) . | NA | {
"id": "C0751992",
"name": "fetal weight",
"pos": [
77,
89
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
109,
115
]
} |
saralasin , an angiotensin ii analogue and receptor blocker , was infused at 7 and 15 micrograms . min-1 into dehydrated conscious merino ewes . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
0,
9
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
15,
29
]
} |
it is suggested that saralasin produced these effects by inhibiting endogenous angiotensin ii activity , and in particular by causing a reduction in renal post-glomerular resistance . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
21,
30
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
79,
93
]
} |
graded dosages of cosyntropin ( synthetic corticotropin ) were injected into groups of normal dogs on consecutive days . | NA | {
"id": "C0010192",
"name": "cosyntropin",
"pos": [
18,
29
]
} | {
"id": "C0001655",
"name": "corticotropin",
"pos": [
42,
55
]
} |
the immunological characterisation of the s typhimurium and s dublin crude extracts revealed that they contained o antigens ( ie , lipopolysaccharides ) and outer membrane proteins , porins . | NA | {
"id": "C0069180",
"name": "o",
"pos": [
9,
10
]
} | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
131,
150
]
} |
thirty anaemic patients with active rheumatoid arthritis were each given 800 mg of iron , as iron dextran , intramuscularly over an interval of four weeks . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
83,
87
]
} | {
"id": "C0022092",
"name": "iron dextran",
"pos": [
93,
105
]
} |
centrally acting drugs ( antiparkinson , antipsychotic , antidepressive and hypotensive agents ) interfere with the activity of the neurotransmitters . | NA | {
"id": "C0007680",
"name": "centrally",
"pos": [
0,
9
]
} | {
"id": "C0040615",
"name": "antipsychotic",
"pos": [
41,
54
]
} |
centrally acting drugs ( antiparkinson , antipsychotic , antidepressive and hypotensive agents ) interfere with the activity of the neurotransmitters . | NA | {
"id": "C0007680",
"name": "centrally",
"pos": [
0,
9
]
} | {
"id": "C0003289",
"name": "antidepressive",
"pos": [
57,
71
]
} |
[ determination of hepatitis b e antigens , anti-hepatitis b e and dane particles in the serum of hepatitis b s carriers and patients with chronic hepatitis b s antigen-positive hepatitis ] . | NA | {
"id": "C0019163",
"name": "hepatitis b",
"pos": [
19,
30
]
} | {
"id": "C0524909",
"name": "chronic hepatitis b",
"pos": [
139,
158
]
} |
it must be realized , however , that in about one third of the patients there will be unavoidable errors which include hematomas in the muscle compartments , posttraumatic swelling , compression of the veins by tumors , aneurysms or cysts , acute forms of lymphedema , erysipelas , and insufficiency of muscle pump in paresis . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
211,
217
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
233,
238
]
} |
- acute toxic lung ( irritant gases such as chlorine , phosgene , nitrous gases ) , occupational asthma , extrinsic alveolitis and finally occupational chronic bronchitis are the principal diseases also observed . | NA | {
"id": "C0008209",
"name": "gases",
"pos": [
30,
35
]
} | {
"id": "C0017110",
"name": "gases",
"pos": [
74,
79
]
} |
oral provocation tests with wine and pure ethanol and inhalation tests with ethanol vapours gave rise to all the known symptoms . | NA | {
"id": "C0043188",
"name": "wine",
"pos": [
28,
32
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
76,
83
]
} |
plasma glucagon immunoreactivity consisted to a large extent ( approx . 90 % ) of a high molecular form of glucagon , probably proglucagon . | NA | {
"id": "C0017687",
"name": "glucagon",
"pos": [
7,
15
]
} | {
"id": "C0072092",
"name": "proglucagon",
"pos": [
127,
138
]
} |
for the myeloid leukemias , the constant recombinants are : the long arm of 9 to chromosome 22 in chronic myeloid leukemia , the long arm of 21 to chromosome 8 in acute myeloblastic leukemia , and the long arm of 17 to chromosome 15 in acute promyelocytic leukemia . | NA | {
"id": "C0023470",
"name": "myeloid leukemias",
"pos": [
8,
25
]
} | {
"id": "C0023473",
"name": "chronic myeloid",
"pos": [
98,
113
]
} |
for the myeloid leukemias , the constant recombinants are : the long arm of 9 to chromosome 22 in chronic myeloid leukemia , the long arm of 21 to chromosome 8 in acute myeloblastic leukemia , and the long arm of 17 to chromosome 15 in acute promyelocytic leukemia . | NA | {
"id": "C0023467",
"name": "acute myeloblastic leukemia",
"pos": [
163,
190
]
} | {
"id": "C0023487",
"name": "acute promyelocytic leukemia",
"pos": [
236,
264
]
} |
compounds that antagonize neuronal excitation induced by dicarboxylic amino acids were tested in two animal models of epilepsy , namely sound-induced seizures in dba/2 mice and threshold pentylenetetrazol seizures in swiss mice . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
118,
126
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
205,
213
]
} |
[ congenital paramyotonia , adynamia episodica hereditaria , or familial periodic paralysis with paramyotonia and hyperkalemia ( author 's transl ) ] . | NA | {
"id": "C0238357",
"name": "adynamia episodica hereditaria",
"pos": [
28,
58
]
} | {
"id": "C0030443",
"name": "familial periodic",
"pos": [
64,
81
]
} |
we believe that eulenburg paramyotonia and gamstorp adynamia episodica hereditaria are two manifestations of the same condition which could be termed familial periodic paralysis with paramyotonia and hyperkaliemia . | NA | {
"id": "C0238357",
"name": "adynamia episodica hereditaria",
"pos": [
52,
82
]
} | {
"id": "C0030443",
"name": "familial periodic paralysis",
"pos": [
150,
177
]
} |
491 cases of non typhoidal salmonella infections were studied in the rouen hospital university centre . | NA | {
"id": "C0041466",
"name": "typhoidal",
"pos": [
17,
26
]
} | {
"id": "C0036117",
"name": "salmonella infections",
"pos": [
27,
48
]
} |
no direct relationship was found between the spinal curvature and the severity or distribution of the lung disease , although the worse scolioses tended to occur in patients with relatively severe pulmonary involvement . | NA | {
"id": "C0037932",
"name": "spinal curvature",
"pos": [
45,
61
]
} | {
"id": "C0036439",
"name": "scolioses",
"pos": [
136,
145
]
} |
the optimal antimicrobial regimen can not be determined from available data , but the combination of ampicillin and an aminoglycoside may offer the best chance for cure . | NA | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
12,
25
]
} | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
119,
133
]
} |
recognition and hence avoidance of factors which evoke seizures is an important part of the management of the epilepsies . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
55,
63
]
} | {
"id": "C0014544",
"name": "epilepsies",
"pos": [
110,
120
]
} |
numerous pulmonary complications associated with rheumatoid arthritis ( ra ) and sjogren 's syndrome ( ss ) have been described . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
49,
69
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
81,
100
]
} |
we report a patient with ra and ss who developed severe irreversible airway obstruction , an association not hitherto described . | NA | {
"id": "C0003873",
"name": "ra",
"pos": [
25,
27
]
} | {
"id": "C1527336",
"name": "ss",
"pos": [
94,
96
]
} |
this series reviews 85 patients operated on for haemothorax and empyema as a result of penetrating chest trauma ( 61 cases ) , blunt chest trauma ( 2 ) , post-pneumonic empyema ( 15 ) , tuberculous empyema ( 4 ) and chronic pneumothorax ( 2 ) . | NA | {
"id": "C0014009",
"name": "empyema",
"pos": [
64,
71
]
} | {
"id": "C0014013",
"name": "pneumonic",
"pos": [
159,
168
]
} |
this series reviews 85 patients operated on for haemothorax and empyema as a result of penetrating chest trauma ( 61 cases ) , blunt chest trauma ( 2 ) , post-pneumonic empyema ( 15 ) , tuberculous empyema ( 4 ) and chronic pneumothorax ( 2 ) . | NA | {
"id": "C0014013",
"name": "pneumonic",
"pos": [
159,
168
]
} | {
"id": "C0014014",
"name": "tuberculous empyema",
"pos": [
186,
205
]
} |
on examination , hepatomegaly was encountered in 66 % of the patients , with moderate to massive enlargement in 40 % . | NA | {
"id": "C0019209",
"name": "hepatomegaly",
"pos": [
17,
29
]
} | {
"id": "C0020564",
"name": "enlargement",
"pos": [
97,
108
]
} |
recently we encountered a patient with an intraventricular hematoma , caused by rupture of an aneurysm of the anterior communicating artery , that persisted as a visible lesion on ct scans two months following the hemorrhage . | NA | {
"id": "C0018944",
"name": "hematoma",
"pos": [
59,
67
]
} | {
"id": "C0019080",
"name": "hemorrhage",
"pos": [
214,
224
]
} |
in order to investigate the effect of ph on bronchial responsiveness to inhaled histamine , 15 subjects with non-specific bronchial hyperreactivity performed two histamine inhalation tests , one with unbuffered , and the other with buffered histamine acid phosphate solutions . | NA | {
"id": "C0019588",
"name": "histamine",
"pos": [
80,
89
]
} | {
"id": "C0062740",
"name": "histamine acid phosphate",
"pos": [
241,
265
]
} |
we conclude that the acid ph of higher concentrations of histamine acid phosphate solutions has a slight but significant enhancing effect on the bronchial responsiveness to inhaled histamine . | NA | {
"id": "C0062740",
"name": "acid",
"pos": [
21,
25
]
} | {
"id": "C0019588",
"name": "histamine",
"pos": [
181,
190
]
} |
we have investigated the role of angiotensin converting enzyme ( ace ) in the development of pulmonary hypertension , right ventricular hypertrophy , and pulmonary vascular disease in rats given a single subcutaneous injection of the pyrrolizidine alkaloid monocrotaline . | NA | {
"id": "C0034335",
"name": "pyrrolizidine alkaloid",
"pos": [
234,
256
]
} | {
"id": "C0085241",
"name": "monocrotaline",
"pos": [
257,
270
]
} |
fibrinogen affecting proteinases may catalyze the release of either fibrinopeptide ( fp ) a ( e.g . ancrod , batroxobin ) or fp b ( agk , contortrix proteinase ) or of both fp a and b ( b. gabonica proteinase ) . | NA | {
"id": "C0030940",
"name": "proteinases",
"pos": [
21,
32
]
} | {
"id": "C0030946",
"name": "proteinase",
"pos": [
198,
208
]
} |
we purified a mixture of isoenzymes by chromatography of the crude venom on deae-sephacel where coagulant proteinase were separated from other proteolytic enzymes . | NA | {
"id": "C0030946",
"name": "proteinase",
"pos": [
106,
116
]
} | {
"id": "C0030940",
"name": "proteolytic enzymes",
"pos": [
143,
162
]
} |
strains of aeromonas hydrophila were earlier shown to produce a heat-labile enterotoxin and two cytolytic toxins , alpha- and beta-haemolysin . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
76,
87
]
} | {
"id": "C0040549",
"name": "toxins",
"pos": [
106,
112
]
} |
blood pressure changes and cardiovascular lesions found in rats given t-2 toxin , a trichothecene secondary metabolite of certain fusarium microfungi . | NA | {
"id": "C0039185",
"name": "t-2 toxin",
"pos": [
70,
79
]
} | {
"id": "C0040952",
"name": "trichothecene",
"pos": [
84,
97
]
} |
rats were treated with beta-naphthoflavone ( bnf ) or phenobarbital ( pb ) , 80 mg/kg i.p . for 4 days and microsomes prepared from the ventral prostate were assayed for aryl hydrocarbon hydroxylase ( ahh ) , 7-ethoxyresorufin-o-deethylase ( 7-eod ) and nadph-cytochrome c reductase activities . | NA | {
"id": "C0003927",
"name": "aryl hydrocarbon hydroxylase",
"pos": [
170,
198
]
} | {
"id": "C0059735",
"name": "7-ethoxyresorufin-o-deethylase",
"pos": [
209,
239
]
} |
adenyl cyclase activity and fluoride content were investigated in various tissues of adult rabbits given naf ( 10 mg/kg body wt./day ) orally for 6 months . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
28,
36
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
105,
108
]
} |
the results support the hypothesis that borate anion exerts its toxic action by interfering with flavin metabolism in flavoprotein-dependent pathways . | NA | {
"id": "C0006007",
"name": "borate",
"pos": [
40,
46
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
47,
52
]
} |
it was suggested , therefore , that the lesions are induced by circulating immune complexes probably formed by non-organspecific antibodies contaminating each antiserum . | NA | {
"id": "C0003313",
"name": "circulating immune complexes",
"pos": [
63,
91
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
129,
139
]
} |
it was suggested , therefore , that the lesions are induced by circulating immune complexes probably formed by non-organspecific antibodies contaminating each antiserum . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
129,
139
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
159,
168
]
} |
the uptake of cholic acid was competitively inhibited by deoxycholic acid , taurocholic acid , glycocholic acid , chenodeoxycholic acid , taurochenodeoxycholic acid and glycochenodeoxycholic acid . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
114,
135
]
} | {
"id": "C0039356",
"name": "taurochenodeoxycholic acid",
"pos": [
138,
164
]
} |
the uptake of cholic acid was competitively inhibited by deoxycholic acid , taurocholic acid , glycocholic acid , chenodeoxycholic acid , taurochenodeoxycholic acid and glycochenodeoxycholic acid . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
114,
135
]
} | {
"id": "C0017903",
"name": "glycochenodeoxycholic acid",
"pos": [
169,
195
]
} |
microtitre wells were coated overnight at room temperature with a 1:64 dilution of antigen in 0.05m carbonate-bicarbonate buffer at ph 9.6 . | NA | {
"id": "C0007026",
"name": "carbonate",
"pos": [
100,
109
]
} | {
"id": "C0005367",
"name": "bicarbonate",
"pos": [
110,
121
]
} |
incubation of isolated sections of rat small intestine in air-saturated medium , deprived of inorganic phosphate ( pi ) was accompanied by liberation of endogenous pi from both sides of the intestinal wall as well as by development of the anion concentration gradient , which was directed from apical to basal side of the wall . | NA | {
"id": "C0031603",
"name": "inorganic phosphate",
"pos": [
93,
112
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
239,
244
]
} |
the kinetics of this reaction ( primed lymphocyte typing , plt ) and its genetic regulation were investigated in one family with a hla-dr homozygous , hla-d heterozygous member , one family with two hla-d homozygous probands , one family with a recombination within the hla system and in three normal families . | NA | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
131,
137
]
} | {
"id": "C0019754",
"name": "hla-d",
"pos": [
199,
204
]
} |
the biochemical characterization of certain , genetically determined disturbances of the lipid transport with the help of apoprotein profiles is the best example for the essential role of these proteins in the lipid metabolism with regard to the clinical diagnostics it is at present not yet possible to get additional informations with the help of the estimation of apoproteins as they would not be got by far simpler methods . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
194,
202
]
} | {
"id": "C0003601",
"name": "apoproteins",
"pos": [
367,
378
]
} |
only few authors try to prove that the proportion of proteins in lipoproteins seems to be somewhat better suited for the differentiation of persons endangered by arteriosclerosis than the proportion of lipids . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
65,
77
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
202,
208
]
} |
with a high probability their profile is influenced by the factors of cardiovascular endangering overweight ( broca-weight greater than or equal to 110 % ) , hypertension ( rr greater than or equal to 160/95 mm hg ) , hypertriglyceridaemia ( greater than or equal to 200 mg/dl ) , hypercholesterolaemia ( greater than or equal to 260 mg/dl ) and hyperuricaemia ( greater than or equal to 6.5 mg/dl in male and greater than or equal to 6.0 mg/dl in female ) . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
97,
107
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
116,
122
]
} |
there were parallelities between the lipid values and the disc-electrophoretically established percental proportions of lipoproteins . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
37,
42
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
120,
132
]
} |
four stages of lymphedema are also distinguished : stage i - latent lymphedema stage ii - reversible lymphedema stage iii - irreversible lymphedema stage iv - elephantiasis . | NA | {
"id": "C0024236",
"name": "lymphedema",
"pos": [
15,
25
]
} | {
"id": "C0013882",
"name": "elephantiasis",
"pos": [
159,
172
]
} |
based on the results of the experiments and the information gained in the examinations criteria are discussed which , when applied , allow positive diatom findings to indicate valuable diagnostic information about death by drowning . | NA | {
"id": "C0011065",
"name": "death",
"pos": [
214,
219
]
} | {
"id": "C0013142",
"name": "drowning",
"pos": [
223,
231
]
} |
after a highly selective vagotomy without pyloroplasty a reduction in the secretory response to pentagastrin and a significant rise of the basic and postprandial gastrin concentration could be observed . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
96,
108
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
162,
169
]
} |
pathogenic anaerobic bacteria may be among the causes of puerperal mastitis which , therefore , was treated by the authors with metronidazole ( vagimid ) and with antibiotics , such as penicillin , oxacillin , erythromycin , and oxytetracycline . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
185,
195
]
} | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
198,
207
]
} |
in the animals investigated , fatty acids of phospholipids from lipid bilayer were found to be more unsaturated than fatty acids of amino phospholipids from rhodopsin microboundary . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
30,
41
]
} | {
"id": "C0015690",
"name": "unsaturated",
"pos": [
100,
111
]
} |
the chronic toxicity test has demonstrated that corpuscular vaccine , antiphagin , adsorbed toxoid and the antigenic complex have low toxicity : their multiple administration in doses exceeding the equivalent doses 30-200 times have been found to exert no influence on the increase of the weight of the animals . | NA | {
"id": "C0042210",
"name": "vaccine",
"pos": [
60,
67
]
} | {
"id": "C0040555",
"name": "toxoid",
"pos": [
92,
98
]
} |
[ experimental study of the allergenic action of a staphylococcal antigenic complex obtained by aqueous extraction compared to other staphylococcal preparations ] . | NA | {
"id": "C0002092",
"name": "allergenic",
"pos": [
28,
38
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
66,
75
]
} |
anaphylactic and skin reactions in guinea pigs immunized with the antigenic staphylococcal complex obtained from strains showing different virulence of the strains has been shown to considerably affect the allergenic activity of the preparation . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
66,
75
]
} | {
"id": "C0002092",
"name": "allergenic",
"pos": [
206,
216
]
} |
similar results have been obtained by means of the model of paw edema in mice , and it has been shown that the staphylococcal antigenic complex produces a lesser allergenic effect than commercial adsorbed toxoid and formalin-treated corpuscular vaccine . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
126,
135
]
} | {
"id": "C0002092",
"name": "allergenic",
"pos": [
162,
172
]
} |
similar results have been obtained by means of the model of paw edema in mice , and it has been shown that the staphylococcal antigenic complex produces a lesser allergenic effect than commercial adsorbed toxoid and formalin-treated corpuscular vaccine . | NA | {
"id": "C0040555",
"name": "toxoid",
"pos": [
205,
211
]
} | {
"id": "C0042210",
"name": "vaccine",
"pos": [
245,
252
]
} |
serum triglycerides , phospholipids , free and total cholesterol were determined , and also was the level of these lipid components in ultracentrifugally isolated lipoprotein lipids . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
163,
174
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
175,
181
]
} |
as to the relative fatty acid composition of serum lecithin the shift induced in palmitic and stearic acids was the same as found in earlier studies when 17c-alkylated exogenous sex steroids were administered , i.e . an increase in the palmitic acid concomitant with a decrease in the stearic . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
19,
29
]
} | {
"id": "C0038230",
"name": "stearic acids",
"pos": [
94,
107
]
} |
out of 314 malignant epithelial tumours 86.0 per cent were squamous carcinomas ( subtypes : 6 % microcarcinomas , 30 % keratinizing , 45 % non keratinizing and 5 % small cell carcinomas ) , 9.0 per cent adenosquamous carcinoma , 3.5 % adenocarcinoma and 1.5 per cent undifferentiated carcinoma . | NA | {
"id": "C0007097",
"name": "malignant",
"pos": [
11,
20
]
} | {
"id": "C0262584",
"name": "small cell",
"pos": [
164,
174
]
} |
plasma amino acids were essentially similar in controls and patients but the intramuscular contents of essential amino acids and of the three branched-chain amino acids were slightly enhanced in the patients . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
7,
18
]
} | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
142,
168
]
} |
familial occurrence of three types of autoantibodies , viz . rheumatoid factors , antinuclear antibodies and thyroid autoantibodies , was investigated in two population series : twins from the finnish twin registry representing the adult twin population living in an urban area ( 76 monozygotic and 82 dizygotic same-sex twin pairs ) and siblings from a middle-aged rural population subject to an ongoing epidemiological study ( 311 sibling groups comprising 801 subjects and 584 married couples ) . | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
38,
52
]
} | {
"id": "C0035448",
"name": "rheumatoid factors",
"pos": [
61,
79
]
} |
familial occurrence of three types of autoantibodies , viz . rheumatoid factors , antinuclear antibodies and thyroid autoantibodies , was investigated in two population series : twins from the finnish twin registry representing the adult twin population living in an urban area ( 76 monozygotic and 82 dizygotic same-sex twin pairs ) and siblings from a middle-aged rural population subject to an ongoing epidemiological study ( 311 sibling groups comprising 801 subjects and 584 married couples ) . | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
38,
52
]
} | {
"id": "C0003243",
"name": "antinuclear antibodies",
"pos": [
82,
104
]
} |
the autoantibodies belonging to the minor , familial component occur in somewhat higher titers , exhibit certain specificity features of their own ( rf reacting with rabbit gamma globulin ) , and are associated with `` '' autoimmune '' '' diseases . | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
4,
18
]
} | {
"id": "C0035448",
"name": "rf",
"pos": [
149,
151
]
} |
the major finding was that overweight students in a behavioral weight control program reported less enjoyment of pleasant activities than did normal weight classroom control subjects . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
10,
17
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
149,
155
]
} |
the major finding was that overweight students in a behavioral weight control program reported less enjoyment of pleasant activities than did normal weight classroom control subjects . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
27,
37
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
149,
155
]
} |
imidazoles , aliphatic substrate analogues and the natural dipeptides , carnosine and anserine , were investigated as inhibitors of diamine oxidase from the pig kidney , human pregnancy plasma and pea seedlings . | NA | {
"id": "C0012512",
"name": "dipeptides",
"pos": [
59,
69
]
} | {
"id": "C0007267",
"name": "carnosine",
"pos": [
72,
81
]
} |
imidazoles , aliphatic substrate analogues and the natural dipeptides , carnosine and anserine , were investigated as inhibitors of diamine oxidase from the pig kidney , human pregnancy plasma and pea seedlings . | NA | {
"id": "C0012512",
"name": "dipeptides",
"pos": [
59,
69
]
} | {
"id": "C0003134",
"name": "anserine",
"pos": [
86,
94
]
} |
the c3 , c4 and c3pa complement fractions were dosed by radial immunodiffusion in the serum of 25 children with ages from 4 to 9 years in a non symptomatic period comprehending 10 atopic asthmas ( 40,0 % of the cases ) 8 non atopic asthmas ( 32.0 % ) and 7 urticarias ( 28,0 % ) . | NA | {
"id": "C0033453",
"name": "c3pa",
"pos": [
16,
20
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
21,
31
]
} |
the serial study demonstrated in the same patient , variations larger than 2 standard deviations in 25,8 % of the assays for c3 , 25,0 % for c4 and 27,2 % for c3pa , what may possibly indicate the great instability of the complement system which depends on a function , consumption or activation and synthesis relation , having to be taken into consideration in those assays comprehending the quantitative study of the seric complement fractions . | NA | {
"id": "C0033453",
"name": "c3pa",
"pos": [
159,
163
]
} | {
"id": "C0009498",
"name": "complement",
"pos": [
425,
435
]
} |
it is concluded that contrast echocardiography offers an opportunity to diagnose a patent foramen ovale noninvasively in patients with suspected paradoxical embolism or with questionable evidence of atrial septal defect . | NA | {
"id": "C0016522",
"name": "patent foramen ovale",
"pos": [
83,
103
]
} | {
"id": "C0018817",
"name": "atrial septal defect",
"pos": [
199,
219
]
} |
giving a bread breakfast containing a quarter of the carbohydrate reduced the breakfast glucose profile but resulted in a significantly impaired blood glucose response to lunch ( 168 % of control , p less than 0.01 ) . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
88,
95
]
} | {
"id": "C0005802",
"name": "in",
"pos": [
117,
119
]
} |
no significant relationships between daily mean sodium dietary intake , drinking water sodium , or sodium index ( amount of drinking water sodium related to diet sodium intake ) , and mean blood pressure levels were found . | NA | {
"id": "C0599638",
"name": "drinking water",
"pos": [
72,
86
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
133,
138
]
} |
twelve cases ( mycosis fungoides , sezary syndrome , cutaneous t-cell lymphoma , chronic lymphocytic leukemia ) were okt3't4 ' , ie , expressed the phenotype commonly associated with mature t-helper cells . | NA | {
"id": "C0036920",
"name": "sezary syndrome",
"pos": [
35,
50
]
} | {
"id": "C0079773",
"name": "cutaneous t-cell lymphoma",
"pos": [
53,
78
]
} |
together with previous observations that kallikrein generated chemotactic activity , possibly via activation of c5 , the present observations suggest that prekallikrein activation may be important for in vivo leukocyte chemotactic response to skin abrasion . | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
41,
51
]
} | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
155,
168
]
} |
valproate sodium syrup repackaged in glass oral syringes and glass vials retained 95 % of valproic acid label claim after storage at 4 and 25 degrees c for 180 days , while valproate sodium syrup repackaged in polypropylene oral syringes did not retain 90 % of label claim after storage for 20 days at 4 or 25 degrees c . | NA | {
"id": "C0042291",
"name": "valproic acid",
"pos": [
90,
103
]
} | {
"id": "C0037567",
"name": "valproate sodium",
"pos": [
173,
189
]
} |
analysis of ( 3h ) -proline incorporation demonstrated a 2.2-fold increase in ( 3h ) -hydroxyproline released into the medium of duchenne myogenic cell clones , whereas intracellular ( 3h ) -hydroxyproline levels showed normal values . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
20,
27
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
191,
205
]
} |
eight patients developed complications from a urachal cyst or sinus , and four patients had a patent urachus with urinary fistula . | NA | {
"id": "C0016169",
"name": "sinus",
"pos": [
62,
67
]
} | {
"id": "C0042021",
"name": "urinary fistula",
"pos": [
114,
129
]
} |
the purpose of the study of 55 pregnancies , in which intravenous glucose tolerance tests ( ivgtts ) were performed during the third trimester , was to examine the hypothesis that evidence of decreased availability of substrates for fetal growth precedes the birth of small-for-gestational age ( sga ) infants ; | NA | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
31,
42
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
127,
142
]
} |
these cells included autologous and homologous fibroblasts , homologous chondrocytes , homologous retinal pigment epithelial cells , heterologous bovine endothelial cells , and heterologous murine embryonal cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
6,
11
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
47,
58
]
} |
these cells included autologous and homologous fibroblasts , homologous chondrocytes , homologous retinal pigment epithelial cells , heterologous bovine endothelial cells , and heterologous murine embryonal cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
6,
11
]
} | {
"id": "C0225369",
"name": "chondrocytes",
"pos": [
72,
84
]
} |
rats were intratracheally instilled with 50 mg of silica as quartz ( 0.5-mu particles ) at day 0 . | NA | {
"id": "C0037098",
"name": "silica",
"pos": [
50,
56
]
} | {
"id": "C0034387",
"name": "quartz",
"pos": [
60,
66
]
} |
protein , proline , and hydroxyproline content ( as an index of total lung collagen ) were quantitated , as were the lung collagen synthesis rate and the total lung protein biosynthesis rate ( evaluated with lung minces in vitro ) . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
10,
17
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
24,
38
]
} |
in control dogs , plasma epinephrine ( epi ) and plasma norepinephrine ( ne ) both increased progressively with time following a midline laparotomy ( delta epi by 50 min , +133 +/- 42 pg/ml , p less than 0.01 and delta ne by 50 min , +108 +/- 38 pg/ml , p less than 0.01 , mean +/- se , n = 12 ) . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
25,
28
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
219,
221
]
} |
in marked contrast , neither morphine nor naloxone affected the plasma ne and epi increases following the administration of 2dg . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
21,
23
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
78,
81
]
} |
systolic pressure , norepinephrine , and epinephrine responses to immobilization stress were greater in the hypercalcemia 10-day transplanted rats . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
20,
34
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
41,
52
]
} |
in the absence of enhanced meal insulin infusion , the subsequent responses of glucose , lactate , pyruvate , alanine , and 10 of 13 other blood amino acids were exaggerated in terms of both amplitude and duration . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
110,
117
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
145,
156
]
} |
the present studies demonstrating that mn2+ does not affect hormone binding or the actions of guanine nucleotides on hormone binding yet totally eliminates the effect of gtp on enzyme activity indicate that the effect of mn2+ occurs at the level of the interactions of the nucleotide regulatory component with the catalytic unit . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
94,
113
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
170,
173
]
} |
to evaluate the contribution of chloride to the suppression of plasma renin activity ( pra ) by kcl , pra was measured before and after venous infusions of kcl , khco3 , kno3 , and kc2h3o2 in dietary nacl-restricted rats . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
32,
40
]
} | {
"id": "C0037494",
"name": "nacl",
"pos": [
200,
204
]
} |
the biliary excretion of [ 3h ] -25-hydroxyvitamin d3 ( [ 3h ] 25 ( oh ) d3 ) was studied in vitamin d-depleted female rats over a 3-h period after intravenous or intraduodenal administration of intact [ 3h ] 25 ( oh ) d3 and after the intraduodenal readministration of the [ 3h ] 25 ( oh ) d3-derived biliary material . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
33,
53
]
} | {
"id": "C2713074",
"name": "25 ( oh ) d3",
"pos": [
63,
75
]
} |
in a search for the physiological mechanisms that could mediate and characterize a satiety function for the hormone cholecystokinin ( cck ) , we examined in macaca mulatta the effect of intraperitoneal injections ( 0.1-0.8 microgram/kg ) and intravenous infusions ( 60-240 ng.kg-1.h-1 ) of the c-terminal octapeptide of cck on gastric emptying of saline test meals . | NA | {
"id": "C0008328",
"name": "cholecystokinin",
"pos": [
116,
131
]
} | {
"id": "C0037167",
"name": "octapeptide",
"pos": [
305,
316
]
} |
plasma epinephrine and norepinephrine concentrations were measured in five harbor seals , phoca vitulina , during a control period , during a 6-min dive , and during a 30-min postdiving recovery period . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
7,
18
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
23,
37
]
} |
control epinephrine concentrations [ 189 +/- 118 ( sd ) pg/ml ] and norepinephrine concentrations ( 340 +/- 191 pg/ml ) were similar to resting values in humans . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
8,
19
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
68,
82
]
} |
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