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stringlengths 57
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stringclasses 125
values | h
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dict |
|---|---|---|---|
parent-offspring and sibling lipid and lipoprotein associations during and after sharing of household environments : the princeton school district family study . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
29,
34
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
39,
50
]
} |
while the apob levels were proportional to beta + pre-beta-lipoprotein cholesterol levels in some children , others had varied levels of apob in relation to cholesterol carried by this apoprotein . | NA | {
"id": "C0023826",
"name": "beta",
"pos": [
43,
47
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
157,
168
]
} |
prior to training , prolonged low intensity exercise resulted in a 20 % decline in plasma glucose , a 2.5-fold rise in plasma free fatty acids ( ffa ) , a 7-fold rise in plasma epinephrine , a 3-fold elevation in plasma norepinephrine , and a 2.5-fold rise in plasma glucagon . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
177,
188
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
220,
234
]
} |
to account for the finding in women of a linear correlation of the decrement in plasma cortisol level with the percent deviation from desirable weight ( which in turn is nearly perfectly correlated with the total body fat content ) , we postulate that a given weight of adipose tissue in women takes up a constant amount of cortisol ; | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
19,
26
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
260,
266
]
} |
groups of hypophysectomized rats were treated with pharmacologic doses of growth hormone , triiodothyronine or cortisone acetate alone or with a combination of growth hormone plus triiodothyronine or growth hormone plus cortisone . | NA | {
"id": "C0056391",
"name": "cortisone acetate",
"pos": [
111,
128
]
} | {
"id": "C0010137",
"name": "cortisone",
"pos": [
220,
229
]
} |
although ketone body production in hepatocytes from both lean and obese rats was increased by fasting , there was a significantly lower rate of ketone body production in hepatocytes from obese rats . | NA | {
"id": "C0022631",
"name": "ketone body",
"pos": [
9,
20
]
} | {
"id": "C0022634",
"name": "ketone",
"pos": [
144,
150
]
} |
cells which had had no prior exposure to isoproterenol responded significantly greater to isoproterenol than did cells that had had prior exposure to the catecholamine , the beta receptor characteristics of cells undergoing beta desensitization were assessed using [ 3h ] dihydroalprenolol . | NA | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
41,
54
]
} | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
154,
167
]
} |
a constant proportional variability of both hbai and plasma glucose over time was demonstrated , the mean coefficient of variation for hbai being 8.4 +/- 2.7 % and for plasma glucose 22.3 +/- 9.7 % . | NA | {
"id": "C0019016",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0019046",
"name": "hbai",
"pos": [
135,
139
]
} |
since these particles were richer in apoprotein e and in cholesteryl ester than were vldl not bound to heparin , we conclude that cholesterol loading leads to an increase in smaller vldl particles , possibly partly catabolized vldl or independently secreted idl , that resemble findings in cholesterol fed animals , and ( 5 ) transport kinetics of apoprotein b in vldl studied in four subjects did not show a rise in production but this does not rule out increased secretion of a cholesteryl ester , apoprotein e enriched subpopulation of vldl . | NA | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
57,
74
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
290,
301
]
} |
since the kidneys are the major site of mevalonate excretion and metabolism by either the sterol or nonsterol shunt pathways , an impairment of any of these metabolic alternatives could result in redistribution of mevalonate to the liver . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
51,
60
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
65,
75
]
} |
the excretion of total sulfur , inorganic sulfate , ester sulfate , `` '' non-sulfate sulfur '' '' , methionine , cystathionine , cysteine , n-acetylcysteine , taurine , thiosulfate and thiocyanate was decreased during fasting , whereas the excretion of mercaptoacetate was unaltered and that of mercaptolactate increased . | NA | {
"id": "C0038720",
"name": "-sulfat",
"pos": [
77,
84
]
} | {
"id": "C0039950",
"name": ", thiosulfa",
"pos": [
168,
179
]
} |
the excretion of total sulfur , inorganic sulfate , ester sulfate , `` '' non-sulfate sulfur '' '' , methionine , cystathionine , cysteine , n-acetylcysteine , taurine , thiosulfate and thiocyanate was decreased during fasting , whereas the excretion of mercaptoacetate was unaltered and that of mercaptolactate increased . | NA | {
"id": "C0010654",
"name": ", cystei",
"pos": [
128,
136
]
} | {
"id": "C0001047",
"name": ", n-acetylcystei",
"pos": [
139,
155
]
} |
the output of ester sulfate , methionine , cystathionine , cysteine and thiosulfate was unaltered in relation to that of total sulfur , indicating that these compounds are derived from both dietary and endogenous sulfur amino acids , liberated during protein catabolism . | NA | {
"id": "C0038720",
"name": "sulfate",
"pos": [
20,
27
]
} | {
"id": "C0039950",
"name": "thiosulfate",
"pos": [
72,
83
]
} |
to determine the respective roles of diabetes and acidaemia in the genesis of the binding defect , insulin binding to adipocytes from alkali-treated ketoacidotic diabetic and ammonium chloride acidotic rats was studied . | NA | {
"id": "C0022638",
"name": "ketoacidotic",
"pos": [
149,
161
]
} | {
"id": "C0001122",
"name": "acidotic",
"pos": [
193,
201
]
} |
previous results from our laboratory demonstrated that chronic administration of fructose to normal rats led to both hyperinsulinemia and in vivo insulin resistance . | NA | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
117,
133
]
} | {
"id": "C0021655",
"name": "insulin",
"pos": [
146,
153
]
} |
the data suggest that the low km system for homocystine transport is shared with cystine and the dibasic amino acids . | NA | {
"id": "C0010682",
"name": "cystine",
"pos": [
48,
55
]
} | {
"id": "C0002523",
"name": "dibasic amino acids",
"pos": [
97,
116
]
} |
a small fraction of single-stranded dna ( ssdna ) , amounting to 1.5 -- 2 % of the total dna , was isolated from native nuclear dna of mouse ascites tumour cells . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
20,
39
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
128,
131
]
} |
in rna-driven annealing reactions , 40 -- 42 % of the ssdna , ( labelled with [ 3h ] -thymidine or 125i ) could be hybridized to cytoplasmic rna was compared with 4 -- 4.5 % for the non repetitious component of bulk dna and 60 -- 63 % of the ssdna could be hybridized to nuclear rna as compared with 20 -- 22 % for bulk dna . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
3,
6
]
} | {
"id": "C0035700",
"name": "nuclear rna",
"pos": [
271,
282
]
} |
this antigen possess two non-cross-reactive antigenic determinants and engenders a restricted antibody response in selected strains of mice . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
5,
12
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
44,
66
]
} |
since precipitins formed with this subpopulation and each of these antigens should have reasonably similar densities and orientations of 'aggregated ' igg but differing combining sites occupancies , we have used this system to explore the relative role of fc aggregation and/or igg distortion vs combining site-transmitted effects on the binding of clq to antibody . | NA | {
"id": "C0032936",
"name": "precipitins",
"pos": [
6,
17
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
356,
364
]
} |
unless combining site-originating contributions are completed when less than 50 % of an antibody-binding site is occupied by ligand , it would seem that clq binding to immune complexes must be governed either by enhanced interactions resulting from fc clustering which occurs via antibody interactions with antigen or by distortion of the antibody molecular upon ligand binding or some combination thereof . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
168,
184
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
339,
347
]
} |
furthermore , the shedding of fcri could be prevented by the addition of transglutaminase or ca2+-ionophore a23187 ( which leads to the activation of pmbc transglutaminase ) to the cell suspension . | NA | {
"id": "C1321301",
"name": "pmbc",
"pos": [
150,
154
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
181,
185
]
} |
n-glycolylneuraminyl ( alpha 2-3 ) lactosyl ceramide ( hematoside ) and n-glycolylneuraminyl ( alpha 2-3 ) lactoneotetraosyl ceramide ( sialosylparagloboside ) were compared by gel precipitation and hemagglutination inhibition using other gangliosides with a related structure and chemically modified hematoside derivatives and the oligosaccharides from both the antigenic glycosphingolipids . | NA | {
"id": "C0017082",
"name": "gangliosides",
"pos": [
239,
251
]
} | {
"id": "C0016897",
"name": "hematoside",
"pos": [
301,
311
]
} |
sister-chromatid exchange and chromosomal aberrations by dhaq and related anthraquinone derivatives in chinese hamster ovary cells . | NA | {
"id": "C0026259",
"name": "dhaq",
"pos": [
57,
61
]
} | {
"id": "C0003174",
"name": "anthraquinone derivatives",
"pos": [
74,
99
]
} |
the induction of sister-chromatid exchanges ( sces ) and chromosomal aberrations in chinese hamster ovary cells by doxorubicin ( adriamycin ) , dhaq and several related anthraquinone derivatives was investigated . | NA | {
"id": "C0026259",
"name": "dhaq",
"pos": [
144,
148
]
} | {
"id": "C0003174",
"name": "anthraquinone derivatives",
"pos": [
169,
194
]
} |
the cytogenetic analysis of persons occupationally exposed to synthetic resins has revealed a true increase in the average frequency of cells with chromosome aberrations : 5.5 % for epoxy resin ( 146 persons ) , 6.1 % for polyvinylchloride ( 52 persons ) , and 5.0 % for phenolformaldehyde ( 31 persons ) . | NA | {
"id": "C0035192",
"name": "synthetic resins",
"pos": [
62,
78
]
} | {
"id": "C0014631",
"name": "epoxy resin",
"pos": [
182,
193
]
} |
this protocol is based upon one developed in sugimura 's laboratory with modifications , including the use of flavin mononucleotide ( fmn ) rather than riboflavin to reduce the azo compounds to free amines , and hamster liver s9 rather then rat liver s9 for metabolic activation . | NA | {
"id": "C0016388",
"name": "fmn",
"pos": [
134,
137
]
} | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
152,
162
]
} |
the poorly hydrolyzed analogs of gtp , guanylyl imidophosphate ( gpp ( nh ) p ) and guanosine 5 ' - ( 3-0-thio ) triphosphate activate the schistosome cyclase in the absence of serotonin . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
33,
36
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
65,
77
]
} |
phosphatidylcholine was the predominant phospholipid in the mlb fraction , comprising 57 % of the total phospholipids . | NA | {
"id": "C0771648",
"name": "phospholipid",
"pos": [
40,
52
]
} | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
104,
117
]
} |
in at least five of the eight patients with viral dna in the liver , the dna was integrated into the genome . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
44,
53
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
73,
76
]
} |
different rank orders of potencies were observed among sp , its c-terminal fragments , analogues and related tachykinins in the different test systems , and these could not be explained by differential access to the target organ receptors . | NA | {
"id": "C0038585",
"name": "sp",
"pos": [
55,
57
]
} | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
109,
120
]
} |
the structural and pharmacological basis for subdividing tachykinins into sp-physalaemin and eledoisin-kassinin families is also discussed . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
57,
68
]
} | {
"id": "C0038585",
"name": "sp",
"pos": [
74,
76
]
} |
the structural and pharmacological basis for subdividing tachykinins into sp-physalaemin and eledoisin-kassinin families is also discussed . | NA | {
"id": "C0039241",
"name": "tachykinins",
"pos": [
57,
68
]
} | {
"id": "C0022528",
"name": "kassinin",
"pos": [
103,
111
]
} |
5-day-old female rats received 60 microgram testosterone propionate ( tp ) along with one of various pregnanes : progesterone , 5 beta-pregnandione , 5 beta , 3 alpha-pregnanolone , 5 beta , 3 beta-pregnanolone , 5 alpha-pregnandione , 5 alpha , 3 beta-pregnanolone , 5 alpha , 3 alpha-pregnanolone or chlormadinone acetate . | NA | {
"id": "C0033006",
"name": "pregnanes",
"pos": [
101,
110
]
} | {
"id": "C0033008",
"name": "pregnanolone",
"pos": [
286,
298
]
} |
anesthetic pregnanes - progesterone , 5 beta-pregnandione and 5 beta , 3 alpha-pregnanolone - counteracted defeminization while nonanesthetic pregnanes - 5 alpha-pregnanes , chlormadinone acetate and 5 beta , 3 beta-pregnanolone - did not . | NA | {
"id": "C0033006",
"name": "pregnanes",
"pos": [
11,
20
]
} | {
"id": "C0033008",
"name": "pregnanolone",
"pos": [
216,
228
]
} |
the potency of three benzodiazepine analogues to inhibit prolactin release correlated with their potency to displace radiolabeled diazepam binding from brain membrane fractions or to induce other biological responses ( clonazepam greater than diazepam greater than chlordiazepoxide ) . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
21,
35
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
265,
281
]
} |
it is speculated that antiepileptic drugs may provoke renal conservation of phosphate which may explain the relative low incidence of manifest rickets or osteomalacia in site of low 25-hydroxy-vitamin d levels in epileptic patients . | NA | {
"id": "C0035579",
"name": "rickets",
"pos": [
143,
150
]
} | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
154,
166
]
} |
although the excitatory amino acids , aspartate and glutamate are present in large quantities in the layers of the mammalian retina where the bipolar and amacrine cells make contact with the retinal ganglion cells , it was not known whether these amino acids are the actual neurotransmitters which excite the retinal ganglion cells . | NA | {
"id": "C0243046",
"name": "excitatory amino acids",
"pos": [
13,
35
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
247,
258
]
} |
the distribution of six neuropeptides ( vasoactive intestinal polypeptide , cholecystokinin octapeptide , substance p , neurotensin , methionine-enkephalin and somatostatin ) has been mapped in the amygdala using immunocytochemical methods . | NA | {
"id": "C0027895",
"name": "neuropeptides",
"pos": [
24,
37
]
} | {
"id": "C0027930",
"name": "neurotensin",
"pos": [
120,
131
]
} |
community studies indicate that although all older children and adults tested have detectable antibodies to rotavirus , there is a significant rise in the number of individuals with high titre antibody in the child bearing age group , after which the levels diminish . | NA | {
"id": "C1455726",
"name": "older children",
"pos": [
45,
59
]
} | {
"id": "C0008059",
"name": "child",
"pos": [
209,
214
]
} |
one , complicated by disseminated intravascular coagulation , rhabdomyolysis , myoglobinuria and renal failure , recovered following peritoneal dialysis . | NA | {
"id": "C0035410",
"name": "rhabdomyolysis",
"pos": [
62,
76
]
} | {
"id": "C0027080",
"name": "myoglobinuria",
"pos": [
79,
92
]
} |
the authors have assayed acetylcholinesterase in second-trimester amniotic fluid samples with previously determined alpha-fetoprotein values from 200 pregnancies with 96.5 % of the outcomes known . | NA | {
"id": "C0032980",
"name": "second-trimester",
"pos": [
49,
65
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
150,
161
]
} |
seventeen patients treated with clomiphene citrate were examined using real-time ultrasound timing 28 ovulatory cycles to determine the pattern of follicular development under clomiphene stimulation . | NA | {
"id": "C0546859",
"name": "clomiphene citrate",
"pos": [
32,
50
]
} | {
"id": "C0009008",
"name": "clomiphene",
"pos": [
176,
186
]
} |
in contrast , relaxin concentrations in pregnancies beyond 43 weeks ' gestation and in women with premature labor were significantly lower than levels in normal women in the third trimester of pregnancy . | NA | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
40,
51
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
174,
189
]
} |
when [ 14c ] phenylalanine was injected into the fetus , radioactive aromatic amino acids in the maternal circulation increased only slightly over time , resembling a simple diffusion process . | NA | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
13,
26
]
} | {
"id": "C0301713",
"name": "aromatic amino",
"pos": [
69,
83
]
} |
the finding of a significantly ( p less than .05 ) lower percent ideal body weight in the women with hot flashes suggests that the known effects of body weight on the rate of extraglandular estrogen production and the level of shbg in postmenopausal women may be important variables determining the occurrence of hot flashes . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
4,
11
]
} | {
"id": "C0005910",
"name": "body weight",
"pos": [
148,
159
]
} |
the finding of a significantly ( p less than .05 ) lower percent ideal body weight in the women with hot flashes suggests that the known effects of body weight on the rate of extraglandular estrogen production and the level of shbg in postmenopausal women may be important variables determining the occurrence of hot flashes . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
4,
11
]
} | {
"id": "C0600142",
"name": "hot flashes",
"pos": [
313,
324
]
} |
the degree of susceptibility of each population to the growth inhibiting effects of dibutyryl camp , a camp analogue , was also measured . | NA | {
"id": "C0012054",
"name": "dibutyryl camp",
"pos": [
84,
98
]
} | {
"id": "C0001455",
"name": "camp",
"pos": [
103,
107
]
} |
large cell anaplastic carcinoma proved to be a 'waste-basket ' containing tumours which displayed ultrastructural characteristics of poorly differentiated squamous cell carcinoma , poorly differentiated adenocarcinoma or neuroendocrine carcinoma . | NA | {
"id": "C0001418",
"name": "adenocarcinoma",
"pos": [
203,
217
]
} | {
"id": "C0206695",
"name": "neuroendocrine carcinoma",
"pos": [
221,
245
]
} |
no statistically significant differences in weight gain were noted between groups , although weight gain in negative control animals and those animals infused with glucose oligosaccharide solutions were lower than those in the other groups . | NA | {
"id": "C0005911",
"name": "differences",
"pos": [
29,
40
]
} | {
"id": "C0043094",
"name": "weight gain",
"pos": [
93,
104
]
} |
rats burn to idm and nursed by either idm or ism for 21 days were given intramuscular iron dextran and placed on iron sufficient diet ( isd ) for 7 days . | NA | {
"id": "C0302583",
"name": "ism",
"pos": [
45,
48
]
} | {
"id": "C0022092",
"name": "iron",
"pos": [
113,
117
]
} |
rats both to ism and nursed by idm were given intramuscular iron dextran on day 21 and placed on an isd from day 21-28 . | NA | {
"id": "C0302583",
"name": "idm",
"pos": [
31,
34
]
} | {
"id": "C0022092",
"name": "iron dextran",
"pos": [
60,
72
]
} |
rats born to and nursed by ism , maintained on iron deficient diet from day 21-84 , and then given intramuscular iron dextran on day 84 and maintained on an isd until day 92 , experienced correction of the hemoglobin , serum iron and lactase levels compared to control rats . | NA | {
"id": "C0302583",
"name": "ism",
"pos": [
27,
30
]
} | {
"id": "C0022092",
"name": "iron dextran",
"pos": [
113,
125
]
} |
in the 13 children with pbb 30-72 micrograms/dl ( 45.3 +/- 14.3 micrograms/dl ) , total cytidine phosphates ( cmp , cdp , ctp ) were significantly ( p less than 0.001 ) increased from trace values to 8.31 +/- 6.21 nmoles/10 ( 10 ) erythrocytes . | NA | {
"id": "C0010848",
"name": "cytidine phosphates",
"pos": [
88,
107
]
} | {
"id": "C0010734",
"name": "ctp",
"pos": [
122,
125
]
} |
during the study period , conjunctival cultures were obtained from 75 patients with purulent conjunctivitis-otitis media and patients with purulent conjunctivitis whose siblings had purulent conjunctivitis-otitis media or otitis media . | NA | {
"id": "C0009768",
"name": "purulent",
"pos": [
84,
92
]
} | {
"id": "C0009763",
"name": "conjunctivitis",
"pos": [
191,
205
]
} |
during the study period , conjunctival cultures were obtained from 75 patients with purulent conjunctivitis-otitis media and patients with purulent conjunctivitis whose siblings had purulent conjunctivitis-otitis media or otitis media . | NA | {
"id": "C0029888",
"name": "purulent",
"pos": [
84,
92
]
} | {
"id": "C0029882",
"name": "otitis",
"pos": [
222,
228
]
} |
these data demonstrate that creatinine output in milligrams per kilogram of body weight increases by 16 % between birth weight of 0.7 and 1.5 kg . | NA | {
"id": "C0005910",
"name": "body weight",
"pos": [
76,
87
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
114,
126
]
} |
gestations were not shortened but newborns of women who worked in the third trimester weighed 150 to 400 gm less than newborns of mothers who remained at home . | NA | {
"id": "C0032961",
"name": "gestations",
"pos": [
0,
10
]
} | {
"id": "C0032981",
"name": "third trimester",
"pos": [
70,
85
]
} |
more recently , studies of the proteinic component of lipoproteins , particularly apoprotein a 1 of hdl lipoproteins and apoprotein b of ldl and vldl lipoproteins , have shown that measurement of apoproteins is of greater help to differentiate between normal subjects and patients with coronary artery disease , irrespective of age . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
54,
66
]
} | {
"id": "C0023825",
"name": "vldl",
"pos": [
145,
149
]
} |
enzymatic digestion studies were performed with rnase t1 , nuclease s1 and the double-strand specific rnase from the venom of the cobra naja naja oxiana . | NA | {
"id": "C0018364",
"name": "rnase t1",
"pos": [
48,
56
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
102,
107
]
} |
this paper describes the minimum length of the turnip yellow mosaic virus ( tymv ) rna necessary to fulfill the trna-like properties of the viral rna : 50 to 75 nucleotides and 86 nucleotides from the 3 ' end of tymv rna are sufficient for adenylation and valylation respectively by the escherichia coli system . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
140,
149
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
217,
220
]
} |
the cleavage of the viral rna by several systems in vitro to yield rna fragments encompassing the trna-like sequence suggests that such fragments might also be liberated in vivo . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
20,
29
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
99,
102
]
} |
in crithidia fasciculata , a trypanosomatid protozoan , the large ribosomal subunit contains five small rna species ( e , f , g , i , j ) in addition to 5s rrna [ gray , m.w . ( 1981 ) mol . cell . biol . 1 , 347-357 ] . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
104,
107
]
} | {
"id": "C0035701",
"name": "rrna",
"pos": [
156,
160
]
} |
it occurs only on single-stranded sv40 dna , suggesting that the dna hairpin can alter the cleavage specificity . | NA | {
"id": "C0012935",
"name": "single-stranded",
"pos": [
18,
33
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
65,
68
]
} |
the positions of the half cysteines suggest that mouse whey acidic protein ( wap ) is a two domain protein , very similar in structure to the plant lectin wheat germ agglutinin and the hypothalamic carrier protein neurophysin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
67,
74
]
} | {
"id": "C0007292",
"name": "carrier protein",
"pos": [
198,
213
]
} |
the positions of the half cysteines suggest that mouse whey acidic protein ( wap ) is a two domain protein , very similar in structure to the plant lectin wheat germ agglutinin and the hypothalamic carrier protein neurophysin . | NA | {
"id": "C0007292",
"name": "carrier protein",
"pos": [
198,
213
]
} | {
"id": "C0027900",
"name": "neurophysin",
"pos": [
214,
225
]
} |
therefore substitutions of protein loss by albumin or thyroid hormones do not seem to be required in patients undergoing hemofiltration . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
27,
34
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
43,
50
]
} |
the characteristics of the uptake of four naturally occurring amino acids , alanine , leucine , lysine and aspartate , by microvesicles prepared from the plasma membrane on the maternal surface of the human placenta were studied . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
62,
73
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
76,
83
]
} |
patients , suffering from thyroid diseases , mainly from moderate and severe goiter , hypothyrosis and hashimoto goiter , developed changes in t- and b-lymphocyte system , manifesting in significant fall of the blood absolute and relative t-cell number and b-lymphocyte count increase . | NA | {
"id": "C0040128",
"name": "thyroid diseases",
"pos": [
26,
42
]
} | {
"id": "C0018021",
"name": "goiter",
"pos": [
113,
119
]
} |
[ insulin and proinsulin content of the blood plasma of latent diabetics with normal body weight ] . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
2,
9
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
14,
24
]
} |
it was shown in the study of insulin and proinsulin content in the blood plasma of patients with the normal body weight , suffering from latent diabetes mellitus , that total plasma immunoreactivity ( tir ) and immunoreactive insulin ( iri ) secretion in the time-course of changes in glucose tolerance test ( gtt ) is more abundant than in healthy subjects during the second secretory phase . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
29,
36
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
41,
51
]
} |
when this fraction was incubated with [ gamma-32p ] atp in the presence of 10 mm mncl2 , hydrolyzed , and assayed , 70 -- 80 % of the radioactivity recovered in phosphoamino acids was in phosphotyrosine . | NA | {
"id": "C0524823",
"name": "phosphoamino acids",
"pos": [
161,
179
]
} | {
"id": "C0070948",
"name": "phosphotyrosine",
"pos": [
187,
202
]
} |
a novel form of dna polymerase i ( deoxynucleosidetriphosphate : dna deoxynucleotidyltransferase , dna nucleotidyltransferase , ec 2.7.7.7 ) activity has been isolated from escherichia coli cells that had been activated for expression of the dna damage-inducible genes . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
242,
245
]
} |
a novel form of dna polymerase i ( deoxynucleosidetriphosphate : dna deoxynucleotidyltransferase , dna nucleotidyltransferase , ec 2.7.7.7 ) activity has been isolated from escherichia coli cells that had been activated for expression of the dna damage-inducible genes . | NA | {
"id": "C0012881",
"name": "deoxynucleotidyltransferase",
"pos": [
69,
96
]
} | {
"id": "C0012882",
"name": "dna nucleotidyltransferase",
"pos": [
99,
125
]
} |
a cloned cdna probe ( 144 bases ) complementary to the region of pro-opiomelanocortin mrna that codes for lipotropin does not hybridize to the rna from bovine adrenal medulla , demonstrating that the latter rna is not pro-opiomelanocortin mrna . | NA | {
"id": "C0023832",
"name": "lipotropin",
"pos": [
106,
116
]
} | {
"id": "C0033195",
"name": "pro-opiomelanocortin",
"pos": [
218,
238
]
} |
tyrosine aminotransferase ( l-tyrosine:2-oxoglutarate aminotransferase , ec 2.6.1.5 ) enzyme and mrna activity were not detectable in day 20 fetal rat liver . | NA | {
"id": "C0041487",
"name": "tyrosine aminotransferase",
"pos": [
0,
25
]
} | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
54,
70
]
} |
when the nonprotein chromophore of neocarzinostatin was allowed to react with either calf thymus dna or poly ( da-dt ) . poly ( da-dt ) in the presence of 2-mercaptoethanol and the dna was precipitated with ethanol , 5 % of the fluorescence attributable to the naphthalene rings of the chromophore coprecipitated with the dna . | NA | {
"id": "C0025402",
"name": "mercaptoethanol",
"pos": [
157,
172
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
207,
214
]
} |
the granule membrane showed high permeability to sugars such as sucrose or sorbitol and to cations . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
49,
55
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
64,
71
]
} |
with these cells , adipocyte formation has been divided experimentally into two stages : ( i ) determination of pre-adipocytes , which have lost the ability to form other cell types while retaining their fibroblast structure ; | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
11,
16
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
204,
214
]
} |
the immunoglobulin fraction of the rabbit antiserum showed the presence and antipeptide antibodies by both agar gel diffusion and radioimmunoassay . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
42,
51
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
88,
98
]
} |
by using an antiserum to rat brain gludcase and the unlabeled antibody -- peroxidase method of sternberger , gludcase immunoreactivity was localized in many terminals within the neurointermediate lobe of the hypophysis . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
12,
21
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
62,
70
]
} |
synthesis of [ half-cys4 , half-cys10 ] -alpha-msh , a cyclic , conformationally restricted , `` '' isosteric '' '' analogue of alpha-msh , provided a melanotropin with a potency greater than 10,000 times that of the native hormone in stimulating frog ( rana pipiens ) skin darkening . | NA | {
"id": "C0002302",
"name": "f alpha-m",
"pos": [
126,
135
]
} | {
"id": "C0026667",
"name": "a melanotrop",
"pos": [
149,
161
]
} |
this polymer undergoes the transition from b dna to left-handed z dna at moderate ionic strength . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
45,
48
]
} | {
"id": "C0043442",
"name": "z dna",
"pos": [
64,
69
]
} |
3t3 cells containing hepatitis b virus dna sequences can be efficiently selected by exposure to methotrexate after cotransfection with cloned viral dna and dna coding for a methotrexate-resistant dihydrofolate reductase . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
142,
151
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
156,
159
]
} |
the present study examines the subunit structure of this receptor by covalently crosslinking two 125i-labeled igfs , igf-i and multiplication-stimulating activity ( msa ) , to chicken embryo fibroblasts by using disuccinimidyl suberate . | NA | {
"id": "C0037657",
"name": "igfs",
"pos": [
110,
114
]
} | {
"id": "C0021665",
"name": "igf-i",
"pos": [
117,
122
]
} |
the present study examines the subunit structure of this receptor by covalently crosslinking two 125i-labeled igfs , igf-i and multiplication-stimulating activity ( msa ) , to chicken embryo fibroblasts by using disuccinimidyl suberate . | NA | {
"id": "C0037657",
"name": "igfs",
"pos": [
110,
114
]
} | {
"id": "C0021666",
"name": "multiplication-stimulating",
"pos": [
127,
153
]
} |
3-methyladenine appears to act specifically upon the autophagic/lysosomal pathway of degradation , as judged from its lack of effect in the presence of amino acids or a lysosomotropic amine ( propylamine ) . | NA | {
"id": "C0002508",
"name": "amine",
"pos": [
184,
189
]
} | {
"id": "C0033504",
"name": "propylamine",
"pos": [
192,
203
]
} |
the variant does not bind phosphocholine attached to carrier or as free hapten in solution but does retain antigenic determinants ( idiotypes ) of the parent . | NA | {
"id": "C0018593",
"name": "hapten",
"pos": [
72,
78
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
107,
129
]
} |
these findings on the close association of atlv protein and proviral dna with atl are direct evidence for the possible involvement of the retrovirus atlv in leukemogenesis of human atl . | NA | {
"id": "C0023492",
"name": "atl",
"pos": [
43,
46
]
} | {
"id": "C0023493",
"name": "human atl",
"pos": [
175,
184
]
} |
this effect was demonstrable by using human neutrophil elastase as well as porcine pancreatic elastase as test enzyme ( elastase , ec 3.4.21.11 ) and was reproducible when selected individuals in each group underwent lavage on repeated occasions . | NA | {
"id": "C0064833",
"name": "human neutrophil",
"pos": [
38,
54
]
} | {
"id": "C0030306",
"name": "elastase",
"pos": [
120,
128
]
} |
in order to relate urinary prostaglandin excretion in pheochromocytoma ( ph ) to the pattern of noradrenaline ( na ) , adrenaline ( a ) and dopamine ( d ) , 14 patients with this disease were investigated during normal sodium intake . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
96,
109
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
119,
129
]
} |
the amounts of pge and f2 alpha synthesized rose from 0.13 and 10.5 ng/mg protein in the growing tumors to a maximum of 1.2 and 26.5 ng/mg protein 5 days after oophorectomy . | NA | {
"id": "C0027642",
"name": "protein",
"pos": [
74,
81
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
139,
146
]
} |
the elevated pgf2 alpha synthesis rates observed in the regressing tumors coupled with a regression-associated increase in receptor number suggests that pgf2 alpha plays a significant role in hormone-dependent mammary tumor regression . | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
67,
73
]
} | {
"id": "C0027661",
"name": "hormone-dependent",
"pos": [
192,
209
]
} |
to investigate the role of renal prostaglandins ( pgs ) in the renal handling of sodium , urinary excretion of pge , pgf2 alpha and pgf2 alpha mum ( main urinary metabolite of pgf2 alpha ) were measured after various manipulations of dietary sodium intake in 8 hypertensive patients . | NA | {
"id": "C0033554",
"name": "prostaglandins",
"pos": [
33,
47
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
111,
114
]
} |
single injections of atropine sulfate or atropine methylnitrate ( a quaternary derivative ) of atropine which does not cross the blood brain barrier ) were given 30 min prior to the session . | NA | {
"id": "C0128170",
"name": "atropine methylnitrate",
"pos": [
41,
63
]
} | {
"id": "C0004259",
"name": "atropine",
"pos": [
95,
103
]
} |
if amphetamine mildly facilitated self-stimulation ( l-amphetamine on dt self-stimulation and d-amphetamine on pfc self-stimulation ) then the addition of naloxone was without effect . | NA | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
3,
14
]
} | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
94,
107
]
} |
if amphetamine greatly increased self-stimulation ( d-amphetamine on dt self-stimulation ) , naloxone caused a depression of the amphetamine effect . | NA | {
"id": "C0011812",
"name": "d-amphetamine",
"pos": [
52,
65
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
129,
140
]
} |
this effect could be reversed partially by simultaneous administration of the catecholamine and serotonin precursors , l-dihydroxyphenylalanine and 5-hydroxytryptophan , respectively . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
78,
91
]
} | {
"id": "C0013023",
"name": "dihydroxyphenylalanine",
"pos": [
121,
143
]
} |
in order to determine if tolerance develops to the inhibition of avoidance behavior by the barbiturates , the effects of barbital on avoidance were determined in rats given barbital in their sole source of drinking water for 7 or 33 days . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
91,
103
]
} | {
"id": "C0004743",
"name": "barbital",
"pos": [
173,
181
]
} |
animals with septal lesions were somewhat lighter in body weight than controls , but since play frequency and body weight were not associated , it is unlikely that changes in body weight caused by the lesions are responsible for the effects of the lesions on play . | NA | {
"id": "C0005910",
"name": "body",
"pos": [
53,
57
]
} | {
"id": "C0005911",
"name": "changes",
"pos": [
164,
171
]
} |
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