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stringlengths 57
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stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
the serum elimination kinetics were characterized by a first-order elimination process with a half-life of 15 h . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
22,
30
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
94,
103
]
} |
labelling index data showed that in ag1518 cells , a diploid human fibroblast strain , there was a lag period of at least 14 hours between subculture from the density-inhibited plateau phase of growth and entry into dna synthesis . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
43,
48
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
67,
77
]
} |
the dna base analogue 5-bromouracil ( bu ) reacts with hydrated electrons to produce a highly reactive uracil-5-yl ( uracilyl ) radical . | NA | {
"id": "C0006242",
"name": "bromouracil",
"pos": [
24,
35
]
} | {
"id": "C0041917",
"name": "uracil",
"pos": [
117,
123
]
} |
herpes simplex virus keratitis , both epithelial and stromal , was more severe in the zinc-deficient rabbit but was not improved by local zinc replacement ( zinc sulphate ointment , 0.05 % ) ; | NA | {
"id": "C0043481",
"name": "zinc",
"pos": [
86,
90
]
} | {
"id": "C0078794",
"name": "zinc sulphate",
"pos": [
157,
170
]
} |
in addition to the well-known calcium-phosphorus deposits , discrete particles containing calcium with little or no phosphorus and calcium in combination with other elements were found . | NA | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
38,
48
]
} | {
"id": "C0013879",
"name": "elements",
"pos": [
165,
173
]
} |
whereas , the enzyme-linked immunosorbent assay is most useful when dissection of antigenic structure is sought because it yields information on the quantities of the antigenic determinants expressed on the cell surface without requiring radioactive reagents . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
82,
91
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
167,
189
]
} |
heritabilities for pelvic area , actual pelvic measures ( horizontal and vertical measures ) , ratios of actual pelvic measures , birth weight , adjusted 205-d weaning weight , postweaning average daily gain , adjusted 365-d weight , weight/d of age and relative growth from weaning to 1 yr of age were computed . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
130,
142
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
234,
240
]
} |
variations in plasma concentrations of certain steroids were associated ( p less than .05 to p less than .01 ) with diet group ( e beta ) , calf sex ( te ) , prepartum day ( all hormones ) , month ( e beta , e alpha ) and linear covariates of cow weight ( e beta , e alpha ) calf birth weight ( e beta , e alpha , e 1 , te ) , temperature ( p4 , e beta ) and photoperiod ( p4 , e beta ) . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
247,
253
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
280,
292
]
} |
for an evaluation of the effects of heat stress during pregnancy on calf birth weight and postpartum maternal milk yield , 21 cows and 10 heifers were assigned to shade ( s ; n = 16 ) or no shade ( ns ; n = 15 ) treatments during the last trimester of pregnancy in june 1978 . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
55,
64
]
} | {
"id": "C0032981",
"name": "last",
"pos": [
234,
238
]
} |
weekly prepartum body weights of dam , birth weight of calf and subsequent daily milk yield were recorded . | NA | {
"id": "C0005910",
"name": "body weights",
"pos": [
17,
29
]
} | {
"id": "C0005612",
"name": "birth weight",
"pos": [
39,
51
]
} |
( 4 ) arginine plus ammonium acetate ( arg + nh4ac ) : 24.00 g arginine . hcl plus 116.34 g ammonium acetate in 2 liters water/24 h . | NA | {
"id": "C0003765",
"name": "arg",
"pos": [
6,
9
]
} | {
"id": "C0301556",
"name": "arginine",
"pos": [
63,
71
]
} |
when bacteroides thetaiotaomicron , an obligate anaerobe from the human colonic flora , was grown in continuous culture with the mucopolysaccharide chondroitin sulfate as the limiting source of carbohydrate , growth yields ranged from 48 g of cell dry weight per mol of equivalent monosaccharide at a growth rate of 3.5 h per generation to 32 g per mol at a growth rate of 24 h per generation . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
194,
206
]
} | {
"id": "C0026492",
"name": "monosaccharide",
"pos": [
281,
295
]
} |
the theoretical maximum growth yield ( 61 g of cell dry weight per mol of equivalent monosaccharide ) was comparable to that of 54 g per mol , which was obtained previously when glucuronic acid , a component of chondroitin sulfate , was the limiting carbohydrate ( s . | NA | {
"id": "C0026492",
"name": "monosaccharide",
"pos": [
85,
99
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
250,
262
]
} |
k ( d ) measurements over a range of cation concentrations revealed that a half-maximal restoration of binding affinity was obtained with relatively low levels ( 10 to 50 mum ) of divalent cations ( e.g. , ca ( 2+ ) , mg ( 2+ ) , and ethylenediammonium ( 2+ ) ions ) . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
37,
43
]
} | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
180,
196
]
} |
k ( d ) measurements over a range of cation concentrations revealed that a half-maximal restoration of binding affinity was obtained with relatively low levels ( 10 to 50 mum ) of divalent cations ( e.g. , ca ( 2+ ) , mg ( 2+ ) , and ethylenediammonium ( 2+ ) ions ) . | NA | {
"id": "C0007447",
"name": "cation",
"pos": [
37,
43
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
260,
264
]
} |
heavy metals , such as mercury , silver , uranium , and molybdate , markedly inhibited the transport activity at 1 mm . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
0,
12
]
} | {
"id": "C0025424",
"name": "mercury",
"pos": [
23,
30
]
} |
heavy metals , such as mercury , silver , uranium , and molybdate , markedly inhibited the transport activity at 1 mm . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
0,
12
]
} | {
"id": "C0037125",
"name": "silver",
"pos": [
33,
39
]
} |
when iron was exhausted , the cells used glucose if the concentration of ferrous sulfate in the medium was higher than 3 % ( wt/vol ) . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
5,
9
]
} | {
"id": "C0060282",
"name": "ferrous",
"pos": [
73,
80
]
} |
as with other binding protein-dependent transport systems , this protein appears to be necessary but not sufficient for transport activity . | NA | {
"id": "C0007292",
"name": "protein",
"pos": [
22,
29
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
65,
72
]
} |
an evaluation of the efficiency of the l-alanine and l-malate transport systems was undertaken with the photosynthetic bacterium rhodospirillum rubrum grown on the amino acid whose uptake was measured . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
41,
48
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
164,
174
]
} |
chloride and other anions make little contribution to the potential , but the presence of ca2+ in the external medium is required for successful potential measurements . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
0,
8
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
19,
25
]
} |
these results indicate that free lipid a is sufficient for pyrogenicity , whereas the complete lipopolysaccharide is the strongest activator of the proclotting enzyme . | NA | {
"id": "C0023767",
"name": "lipid",
"pos": [
33,
38
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
95,
113
]
} |
the enzyme had a broad substrate specificity and reduced aromatic and aliphatic aldehydes such as dihydro-6-formylpterin , benzaldehyde , pyridine-3-aldehyde , butyraldehyde , dl-glyceraldehyde , and acetaldehyde . | NA | {
"id": "C0001992",
"name": "aldehydes",
"pos": [
80,
89
]
} | {
"id": "C0017854",
"name": "glyceraldehyde",
"pos": [
179,
193
]
} |
the enzyme had a broad substrate specificity and reduced aromatic and aliphatic aldehydes such as dihydro-6-formylpterin , benzaldehyde , pyridine-3-aldehyde , butyraldehyde , dl-glyceraldehyde , and acetaldehyde . | NA | {
"id": "C0001992",
"name": "aldehydes",
"pos": [
80,
89
]
} | {
"id": "C0000966",
"name": "acetaldehyde",
"pos": [
200,
212
]
} |
zearalenone and its derivatives ( alpha-zearalenol and alpha-zearalanol ) , estrogenic mycotoxins produced by fusarium species , when added in vivo and in vitro to immature rat uteri , induced the incorporation of labeled amino acids into a specific uterine protein ( induced protein ) . | NA | {
"id": "C0043454",
"name": "zearalenone",
"pos": [
0,
11
]
} | {
"id": "C0043465",
"name": "zearalanol",
"pos": [
61,
71
]
} |
all these proteochemical and enzymatic properties of kidney alpha-glucosidase were the same as those of urine f-1 alpha-glucosidase . | NA | {
"id": "C0002272",
"name": "alpha-glucosidase",
"pos": [
60,
77
]
} | {
"id": "C0017764",
"name": "glucosidase",
"pos": [
120,
131
]
} |
analysis of the anti-albumin precipitate of the exported protein by two-dimensional gel electrophoresis showed that the electrophoretic behavior precisely coincided with that of authentic mouse serum albumin . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
21,
28
]
} | {
"id": "C0036773",
"name": "serum albumin",
"pos": [
194,
207
]
} |
in this report , we describe the separation of high and low molecular weight forms of rat liver arginyl-trna synthetase , and the extensive purification to near homogeneity of the low molecular weight form of the enzyme , free of other aminoacyl-trna synthetases . | NA | {
"id": "C0003778",
"name": "arginyl-trna synthetase",
"pos": [
96,
119
]
} | {
"id": "C0002529",
"name": "aminoacyl-trna synthetases",
"pos": [
236,
262
]
} |
synthetic estrogens : hexestrol greater than moxestrol greater than ethinyl estradiol much greater than chlorotrianisene and mestranol ) . | NA | {
"id": "C0015011",
"name": "ethinyl estradiol",
"pos": [
68,
85
]
} | {
"id": "C0025506",
"name": "mestranol",
"pos": [
125,
134
]
} |
anthramycin , an antitumor antibiotic produced by streptomyces refuineus , produces a well defined covalent adduct with dna and lies within the narrow groove of dna , attached through a thermal-labile covalent animal linkage to the exocyclic amino group of guanine , without detectable distortion of the helix ( petrusek , r. l. , anderson , g. l. , garner , t. f. , fannin , q. l. , kaplan , d. j. zimmer , s. g. , and hurley , l. h. ( 1981 ) biochemistry 20 , 1111-1119 ) . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
161,
164
]
} |
it was found that a third lipid hapten containing the dinitrophenyl group does not show this strong dependence of antibody binding on the physical state of the lipid membrane . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
26,
31
]
} | {
"id": "C0025249",
"name": "lipid",
"pos": [
160,
165
]
} |
limited proteolysis of factor v by thrombin led to formation of factor va which has a cofactor activity 25- to 30-fold that of factor v . | NA | {
"id": "C0015501",
"name": "factor va",
"pos": [
64,
73
]
} | {
"id": "C0015498",
"name": "factor v",
"pos": [
127,
135
]
} |
the amino-acid composition analysis of the purified antigens indicated that the amino acids in the highest content were glycine ( 15 % ) , glutamic acid ( 11.6 % ) , and serine ( 9 % ) ; | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
80,
91
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
120,
127
]
} |
this antigen is the first purified nuclear antigen that reacts with the hela-specific nucleolar antibodies . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
5,
12
]
} | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
35,
50
]
} |
it is concluded that alterations in the ability to spread on the substratum and to form cell-cell contacts are common features of morphologically transformed fibroblastic and epithelial cultures . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
88,
92
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
158,
170
]
} |
only two major proteins ( an as yet unidentified cytoplasmic protein and globin ) are reproducibly induced , while the synthesis of a few proteins is almost completely abolished . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
15,
23
]
} | {
"id": "C0034861",
"name": "synthesis",
"pos": [
119,
128
]
} |
liquid chromatography with electrochemical detection is used for the determination of adrenaline , noradrenaline and dopamine in rat heart tissue , and the method has also been applied to the determination of basic levels of these compounds in blood plasma . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
86,
96
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
99,
112
]
} |
determination of cefsulodin , cefotiam , cephalexin , cefotaxime , desacetyl-cefotaxime , cefuroxime and cefroxadin in plasma and urine by high-performance liquid chromatography . | NA | {
"id": "C0007556",
"name": "cefotiam",
"pos": [
30,
38
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
77,
87
]
} |
determination of cefsulodin , cefotiam , cephalexin , cefotaxime , desacetyl-cefotaxime , cefuroxime and cefroxadin in plasma and urine by high-performance liquid chromatography . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
54,
64
]
} | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
90,
100
]
} |
elevations of a number of metabolites were observed including several short chain ketones , acetophenone , 2-acetylfuran and indole . | NA | {
"id": "C0022634",
"name": "ketones",
"pos": [
82,
89
]
} | {
"id": "C0001006",
"name": "acetophenone",
"pos": [
92,
104
]
} |
two extraction methods are used : anion exchange on deae-sephadex columns and organic solvent extraction with five different solvents : diethyl ether , ethyl acetate , isopropyl chloride , light petroleum , and tetrahydrofuran . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
34,
39
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
178,
186
]
} |
this study examines the effect of baclofen , a specific gamma-aminobutyric acid analog which crosses the blood-brain barrier freely , upon insulin , glucagon , and gh responses to iv glucose in normal man . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
34,
42
]
} | {
"id": "C0016904",
"name": "gamma-aminobutyric acid",
"pos": [
56,
79
]
} |
the d-trp6 lrh and lrh were quantitated individually by sensitive and specific rias which did not cross-react with the other peptide infused or fragments of the degraded peptides . | NA | {
"id": "C0030956",
"name": "peptide",
"pos": [
125,
132
]
} | {
"id": "C0030935",
"name": "fragments",
"pos": [
144,
153
]
} |
we have found that these cells secreted no immunoreactive pregnancy-specific beta 1-glycoprotein ( ps beta g ) , a placental protein . | NA | {
"id": "C0033002",
"name": "pregnancy-specific beta",
"pos": [
58,
81
]
} | {
"id": "C0032974",
"name": "placental protein",
"pos": [
115,
132
]
} |
a group of 10 borderline hypertensive obese subjects had higher ( p less than 0.05 ) supine plasma norepinephrine ( ne ) , epinephrine , and pra levels as well as greater ( p less than 0.05 ) ne responses to upright posture and isometric handgrip exercise than 12 nonobese controls . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
99,
113
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
123,
134
]
} |
in 15 normotensive obese subjects as well as in the 10 borderline hypertensive obese subjects , weight reduction associated with a very low calorie intake was accompanied by a reduction in supine plasma ne , epinephrine , and map 2 weeks after the onset of dieting . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
63,
65
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
208,
219
]
} |
effects of nicotinic acid therapy on plasma lipoproteins and very low density lipoprotein apoprotein c subspecies in hyperlipoproteinemia . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
44,
56
]
} | {
"id": "C0023825",
"name": "very low density",
"pos": [
61,
77
]
} |
the effects of long term treatment with nicotinic acid on lipids , lipoproteins , and the plasma distribution of very low density lipoproteins ( vldl ) apoprotein c ( apoc ) subspecies were studied in 33 patients with types iia ( n = 9 ) , iib ( n = 11 ) , and iv ( n = 13 ) hyperlipidemias . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
58,
64
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
130,
142
]
} |
the effects of long term treatment with nicotinic acid on lipids , lipoproteins , and the plasma distribution of very low density lipoproteins ( vldl ) apoprotein c ( apoc ) subspecies were studied in 33 patients with types iia ( n = 9 ) , iib ( n = 11 ) , and iv ( n = 13 ) hyperlipidemias . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
67,
79
]
} | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
113,
142
]
} |
correlation coefficients calculated between extreme values of pulse rates and of systolic and diastolic blood pressures on the one hand and plasma free and conjugated norepinephrine , epinephrine , and dopamine ( da ) sampled at the height of the crises on the other , showed no relationships between free or conjugated norepinephrine or epinephrine and blood pressure or pulse rate . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
167,
181
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
338,
349
]
} |
eighteen of the 41 cases ( 44 % ) showed transient increases in the serum free t4 index ( ft4 index ) during weeks 10 -- 15 of pregnancy , but normal thyroid function in the second and third trimesters . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
127,
136
]
} | {
"id": "C0032981",
"name": "third",
"pos": [
185,
190
]
} |
a 14-yr-old woman presented with fasting hyperglycemia ( 269 mg/dl ) , fasting hyperinsulinemia ( 45 microu/ml ) , acanthosis nigricans , and insulin resistance . | NA | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
79,
95
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
142,
160
]
} |
to confirm that the severe reduction in cellular insulin receptors was a primary rather than an acquired defect , similar studies were conducted using cultured fibroblasts . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
40,
48
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
160,
171
]
} |
abnormalities in vitamin d metabolism do not appear to contribute to the pathogenesis of this rare hereditary form of rickets or osteomalacia , which occurs despite normal circulating calcium , inorganic phosphate , and vitamin d metabolite levels . | NA | {
"id": "C0035579",
"name": "rickets",
"pos": [
118,
125
]
} | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
129,
141
]
} |
2 ) the in vitro dissociation rate of the receptor-steroid complex is faster than normal : 3 ) the cellular androgen receptor is more thermolabile than normal when cells are exposed to superphysiological temperatures ; | NA | {
"id": "C0034840",
"name": "receptor-steroid",
"pos": [
42,
58
]
} | {
"id": "C0034786",
"name": "androgen",
"pos": [
108,
116
]
} |
it is likely that these enzymes are closely coupled , resulting in the rapid metabolism of e2 by formation and excretion of estrone sulfate . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
77,
87
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
111,
120
]
} |
the average proportions of the myosin heavy chain associated with high actin-activated myosin atpase were 86 , 74 and 6 % for groups t3 , c and tx respectively . | NA | {
"id": "C0027100",
"name": "myosin heavy chain",
"pos": [
31,
49
]
} | {
"id": "C0027096",
"name": "myosin atpase",
"pos": [
87,
100
]
} |
the amino acid composition of amphioxus paramyosin , although similar to that of invertebrate paramyosin , showed differences : a higher content of proline , a lower amount of dicarboxylic amino acids , and a lysine/arginine ratio greater than one . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0002524",
"name": "dicarboxylic amino acids",
"pos": [
176,
200
]
} |
pth did not stimulate rbc na-k-activated atpase or mg-dependent atpase but caused marked and significant stimulation of ca-activated atpase . | NA | {
"id": "C0001479",
"name": "na-k",
"pos": [
26,
30
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
133,
139
]
} |
in searching for alternate immunogens , we have studied the protective potential of polysaccharide-poor , lipid-rich endotoxin ( lps ) core in experimental hib infections . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
117,
126
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
129,
132
]
} |
factor xi , the zymogen form of factor xia , circulates in plasma associated with the contact system cofactor , high molecular weight kininogen ( hmw kininogen ) . | NA | {
"id": "C0015522",
"name": "factor xi",
"pos": [
0,
9
]
} | {
"id": "C0015524",
"name": "factor xia",
"pos": [
32,
42
]
} |
nonhemoglobin-producing normal human fibroblasts , which appear to have a much lower iron requirement than reticulocytes , contain similar numbers of immunoreactive receptors per cell ( 400,000 receptor molecules ) , when in an active state of proliferation . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
37,
48
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
179,
183
]
} |
although receptor density on fibroblasts is directly related to cell proliferation , our studies demonstrate that nonproliferating fibroblasts still retain significant numbers of immunoreactive receptors ( 150,000 molecules/cell ) and transferrin binding sites . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
29,
40
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
224,
228
]
} |
as determined by a substrate competition assay , the abnormal lipoprotein was a less efficient substrate for purified bovine milk lipoprotein lipase than control lipoproteins . | NA | {
"id": "C0065058",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
162,
174
]
} |
purified factor viii that has not been activated by thrombin or factor xa supports factor x activation after a lag of several minutes . | NA | {
"id": "C0015520",
"name": "factor xa",
"pos": [
64,
73
]
} | {
"id": "C0015518",
"name": "factor x",
"pos": [
83,
91
]
} |
these data support the conclusion that unactivated factor viii has no ability to support factor x activation in a purified system until it is activated by factor xa feedback during the lag period . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
89,
97
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
155,
164
]
} |
the effect of activated factor viii on the kinetics of bovine factor x activation was primarily to increase the vmax ( 54-fold ) , whereas with human factor x , factor viii both increased the vmax 56-fold and decreased the km sixfold to 0.14 microm , similar to the plasma concentration of factor x . | NA | {
"id": "C0015514",
"name": "activated factor viii",
"pos": [
14,
35
]
} | {
"id": "C0015506",
"name": "factor viii",
"pos": [
161,
172
]
} |
it is not always possible to demonstrate a csf leakage with ct cisternography ( ctc ) using metrizamide , particularly in cases with minute fistulas or intermittent csf rhinorrhea . | NA | {
"id": "C0023182",
"name": "csf leakage",
"pos": [
43,
54
]
} | {
"id": "C0007815",
"name": "csf rhinorrhea",
"pos": [
165,
179
]
} |
the performance of second-year preclinical students who fabricated cast restorations with a technique alloy were compared to the performance of students who used a conventional gold alloy . | NA | {
"id": "C0002154",
"name": "alloy",
"pos": [
102,
107
]
} | {
"id": "C0018027",
"name": "gold alloy",
"pos": [
177,
187
]
} |
thus , technique alloys can be used as economical substitutes for gold alloys in preclinical teaching situations . | NA | {
"id": "C0002154",
"name": "alloys",
"pos": [
17,
23
]
} | {
"id": "C0018027",
"name": "gold alloys",
"pos": [
66,
77
]
} |
three penicillin-allergic patients with life-endangering infections requiring beta-lactam antibiotic therapy were desensitized by means of increasing oral then parenteral doses and were treated with full doses of beta-lactam agents . | NA | {
"id": "C0030842",
"name": "penicillin",
"pos": [
6,
16
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
213,
224
]
} |
three penicillin-allergic patients with life-endangering infections requiring beta-lactam antibiotic therapy were desensitized by means of increasing oral then parenteral doses and were treated with full doses of beta-lactam agents . | NA | {
"id": "C0026458",
"name": "beta-lactam antibiotic",
"pos": [
78,
100
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
213,
224
]
} |
malignant otitis externa caused by pseudomonas aeruginosa , osteomyelitis caused by staphylococcus aureus , and bacterial endocarditis caused by an enterococcus were treated with carbenicillin , nafcillin , and benzylpenicillin g , respectively . | NA | {
"id": "C0006976",
"name": "carbenicillin",
"pos": [
179,
192
]
} | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
211,
227
]
} |
in patients taking non-chloride salts of potassium , there was a significantly higher prevalence of hypokalemia than in those taking the chloride salt ( 3.6 per cent vs. 8 per cent , p less than 0.025 ) . | NA | {
"id": "C0032825",
"name": "chloride",
"pos": [
23,
31
]
} | {
"id": "C0008203",
"name": "chloride salt",
"pos": [
137,
150
]
} |
cultured skin fibroblast-like cells have markedly reduced growth potential and a characteristic pattern of multiple , variable , stable structural chromosomal rearrangements that are non-constitutional . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
14,
24
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
30,
35
]
} |
by using an antiserum to purified human renal renin , renin was localized immunocytochemically in the human kidney under normal and various pathological conditions by the unlabeled antibody enzyme light microscope : ( lm ) and protein a-gold colloid electron microscope ( em ) procedures . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
12,
21
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
181,
189
]
} |
the igg fraction of antiserum and the f ( ab ' ) 2 and fab ' fragments of the antibody , which possess a comparable reactivity in regard to the trf acceptor site ( s ) , were prepared , and analysis of the b cell-triggering mechanism by the antibody was carried out . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
20,
29
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
241,
249
]
} |
depending on the antibody pair chosen , the affinity of the mixture was as much as 10-fold higher than either of the monoclonal antibodies assayed separately . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
17,
25
]
} | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
117,
127
]
} |
the development of an immune response to rubella virus in milk , serum , and nasopharyngeal secretions was studied in lactating postpartum women after immunization with hpv-77 de5 or ra 27/3 live , attenuated rubella virus vaccine administered subcutaneously or intranasally . | NA | {
"id": "C0035924",
"name": "rubella virus",
"pos": [
41,
54
]
} | {
"id": "C0035923",
"name": "rubella virus vaccine",
"pos": [
209,
230
]
} |
this plasmid-mediated beta-lactamase differed from the two types of chromosomal cephalosporinases ( pi 7.4 and 9.3 , respectively ) found in a survey of clinical isolates of achromobacter species . | NA | {
"id": "C0597979",
"name": "beta-lactamase",
"pos": [
22,
36
]
} | {
"id": "C0728805",
"name": "cephalosporinases",
"pos": [
80,
97
]
} |
2 ) the produced crystal during heat treatment of the powder compacts made from pyrex glass powder with quartz powder were cristobalite . | NA | {
"id": "C0034387",
"name": "quartz",
"pos": [
104,
110
]
} | {
"id": "C0037098",
"name": "cristobalite",
"pos": [
123,
135
]
} |
fiber may be divided into two broad chemical classes : 1 ) non-alpha-glucan polysaccharides ( cellulose , hemicelluloses , and pectins ) and 2 ) lignins . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
94,
103
]
} | {
"id": "C0023705",
"name": "lignins",
"pos": [
145,
152
]
} |
certain types of fiber decrease the rate of glucose absorption and attenuate postprandial rises in blood glucose and insulin . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
44,
51
]
} | {
"id": "C0005802",
"name": "in",
"pos": [
122,
124
]
} |
crystallization of the saturated triglycerides could occur during routine lipoprotein isolation , in which temperatures much lower than the melting points of their core lipids are employed . when protocols are done entirely at 37 degrees c , the unusual structures are not observed in the intermediate density class . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
74,
85
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
169,
175
]
} |
although the saturated fats in these bovine lipoproteins are derived from ruminal fermentation , we feel that any triglyceride-rich lipoprotein highly enriched in saturated fats will behave similarly if isolation temperatures are well below the melting points of the core lipids . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
44,
56
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
272,
278
]
} |
in order to investigate the structure and stability of cholesterol-enriched dispersions of phosphatidylcholine ( pc ) , cholesterol/dipalmitoyl phosphatidylcholine ( dppc ) mixtures with molar ratios of 4 +/- 0.5/1 to 1/1 were dispersed in water by sonication . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
91,
110
]
} | {
"id": "C0000039",
"name": "dipalmitoyl",
"pos": [
132,
143
]
} |
the bilayers which have a repeat distance of 66 a in these particles at 20 degrees c can contain up to 4 mol cholesterol/mol pc when dppc is used and about half this ratio with egg pc . | NA | {
"id": "C1959616",
"name": "pc",
"pos": [
125,
127
]
} | {
"id": "C0000039",
"name": "dppc",
"pos": [
133,
137
]
} |
under conditions of gentle mixing , the maximum solubility of cholesterol in dppc bilayers is 1.0 +/- 0.1 mol/mol pc when the mixture initially contains less than about 3 mol cholesterol/mol dppc . | NA | {
"id": "C1959616",
"name": "pc",
"pos": [
79,
81
]
} | {
"id": "C0000039",
"name": "dppc",
"pos": [
191,
195
]
} |
the results provide the first demonstrations that dgts is a bona fide membrane lipid and , specifically , that ether-linked homoserine lipid is a component of the thylakoid membrane of a phototrophic green-plant cell . | NA | {
"id": "C0025249",
"name": "membrane lipid",
"pos": [
70,
84
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
135,
140
]
} |
hdl and ldl labeled with [ 24,25-3h ] cholesteryl esters were prepared by ultracentrifugation of plasma from donor rats injected 24 hr previously with [ 24,25-3h ] cholesterol in propylene glycol . | NA | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
38,
56
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
164,
175
]
} |
since oxidation of cholesterol is a measure of bile acid formation , it is concluded that under the conditions of the study hdl-cholesterol is a better precursor of bile acids than ldl-cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
19,
30
]
} | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
124,
139
]
} |
since oxidation of cholesterol is a measure of bile acid formation , it is concluded that under the conditions of the study hdl-cholesterol is a better precursor of bile acids than ldl-cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
19,
30
]
} | {
"id": "C0023824",
"name": "ldl-cholesterol",
"pos": [
181,
196
]
} |
fractionation of the lipoproteins on the basis of particle size by chromatography on sephacryl s-300 permitted partial separation of two major and at least three other minor components which differed in their lipid : protein ratio and their apolipoprotein content . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
21,
33
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
209,
214
]
} |
the second major component contained predominantly apoa-i , together with apoe , and in addition , an apolipoprotein of molecular weight 46,000 that was not cleaved by reduction of disulfide bonds , and which was identified as apoa-iv . | NA | {
"id": "C0003595",
"name": "apoe",
"pos": [
74,
78
]
} | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
102,
116
]
} |
a second apoe-containing lipoprotein , which contained apoa-i and apoe in a ratio of approximately 2:1 , was also present as a minor component , together with two or more minor components whose apoproteins were comprised of apoa-i and apoc . | NA | {
"id": "C0003595",
"name": "apoe",
"pos": [
9,
13
]
} | {
"id": "C0052198",
"name": "apoe",
"pos": [
66,
70
]
} |
these results are discussed in terms of a thermotropic reordering of cholesterol clusters existing in the erythrocyte membrane and of the cholesteryl ester core present within the low density lipoprotein particle . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
69,
80
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
138,
155
]
} |
in adipose tissue of htg patients , the amount of radioactive fatty acids incorporated into triacylglycerols ( tg ) was 50 % lower ( p less than 0.025 ) , whereas that incorporated into tissue ffa was three times higher ( p less than 0.01 ) when compared with control patients . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
62,
73
]
} | {
"id": "C0015688",
"name": "ffa",
"pos": [
193,
196
]
} |
these results indicate that 13-cis ra is partially isomerized to all-trans ra and that all-trans ra is rapidly metabolized to highly polar compounds in tissues of vitamin a-sufficient rats . | NA | {
"id": "C0040845",
"name": "all-trans ra",
"pos": [
65,
77
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
163,
172
]
} |
inflammatory causes have been recognized more recently , epidemiological and histological studies confirming their presence and the multiple etiologies involved : horton 's disease , rheumatic disorders , connective tissue diseases . | NA | {
"id": "C0035435",
"name": "rheumatic disorders",
"pos": [
183,
202
]
} | {
"id": "C0009782",
"name": "connective",
"pos": [
205,
215
]
} |
caudal lymph heart frequency increases when high concentrations ( greater than 1 x 10 ( -6 ) m ) and doses ( greater than 1 nmol ) of ad and na were administered . | NA | {
"id": "C0014563",
"name": "ad",
"pos": [
134,
136
]
} | {
"id": "C0028351",
"name": "na",
"pos": [
141,
143
]
} |
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