text
stringlengths 57
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| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
with xylulose 5-phosphate as the ketol-donor , aliphatic aldehydes ( c1-c7 ) , glycolaldehyde and glyceraldehyde were better acceptors than ribose 5-phosphate . | NA | {
"id": "C0001992",
"name": "aldehydes",
"pos": [
57,
66
]
} | {
"id": "C0017854",
"name": "glyceraldehyde",
"pos": [
98,
112
]
} |
[ dependence of muscle protein atpase and creatine kinase activities and actomyosin filaments contractility on urea concentration ] . | NA | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
16,
30
]
} | {
"id": "C0001291",
"name": "actomyosin",
"pos": [
73,
83
]
} |
it was found that variations in the amount of non-soluble cellulose and the corresponding changes in cellobiase activity in the system ( as a result of the adsorption ) can lead to a certain alteration in the shape of the kinetic curves for formation of intermediate cellobiose , which in its turn controls the rate of formation of the end product , i.e . glucose . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
58,
67
]
} | {
"id": "C0007630",
"name": "cellobiose",
"pos": [
267,
277
]
} |
the lack of dependence of activity of peptide perminductors on the membrane lipid composition can probably be due to the fact that their effects is localized in the carbohydrate moiety of the lipid bilayer and does not involve the polar `` '' heads '' '' of the lipids . | NA | {
"id": "C0025249",
"name": "membrane",
"pos": [
67,
75
]
} | {
"id": "C0023768",
"name": "lipid bilayer",
"pos": [
192,
205
]
} |
the increased activation of adenylate cyclase by fluoride in the presence of atp can be due to the fact that the enzyme affinity for the substrate is decreased in the presence of naf . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
49,
57
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
179,
182
]
} |
it was shown that there exist two types of the enzymes differing in their ability to bind to cellulose and to degrade mcc . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
93,
102
]
} | {
"id": "C0669247",
"name": "mcc",
"pos": [
118,
121
]
} |
on the contrary , the other group of the enzymes irreversibly binds to cellulose and shows a noticeable ability to solubilize mcc . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
71,
80
]
} | {
"id": "C0669247",
"name": "mcc",
"pos": [
126,
129
]
} |
the variation in diffusion coefficient with ionic strength has also been considered by following the diffusion of 0.45 % lysozyme chloride in a series of potassium chloride solutions . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
130,
138
]
} | {
"id": "C0032825",
"name": "potassium chloride",
"pos": [
154,
172
]
} |
the dependence of the lateral distribution of membrane proteins on the size , protein/lipoid molar ratio , and the magnitude of the interaction potentials has been investigated by computer modeling protein-lipid distributions with monte carlo calculations . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
46,
63
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
198,
205
]
} |
photoactive planar model membranes were formed both from biomolecular lipid membranes and from solid 6-micrometers thick teflon septa coated with lipid and bacteriorhodopsin . | NA | {
"id": "C0025249",
"name": "lipid membranes",
"pos": [
70,
85
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
146,
151
]
} |
we show that interesting oscillatory patterns may arise from an immobilized enzyme system , when the enzyme has the properties that it is inhibited by a substrate , produces h+ and has a ph-activity curve of bell-shaped form . | NA | {
"id": "C0014444",
"name": "immobilized",
"pos": [
64,
75
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
101,
107
]
} |
to determine whether ba-1 also reacts with hematopoietic progenitor cells ( hpc ) , we studied the effect of removal of ba-1+ cells from human bone marrow on the proliferation in vitro of the trilineage precursor cell cfu-gemm , and on the committed progenitor cells of granulopoiesis ( cfu-c ) and erythropoiesis ( bfu-e/cfu-e ) . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
16,
19
]
} | {
"id": "C0018956",
"name": "precursor cell",
"pos": [
203,
217
]
} |
a liquid culture system for cloning and growing bone marrow fibroblasts has permitted us to approach more directly the understanding of the pathogenesis of myelofibrosis by comparing the biophysical , growth , and functional characteristics of fibroblasts from normals , mpd patients without mf , and those with mf . | NA | {
"id": "C0027022",
"name": "mpd",
"pos": [
271,
274
]
} | {
"id": "C0001815",
"name": "mf",
"pos": [
312,
314
]
} |
marrow fibroblasts from mpd patients with and without mf displayed the same in vitro growth characteristics as fibroblasts from normals . | NA | {
"id": "C0027022",
"name": "mpd",
"pos": [
24,
27
]
} | {
"id": "C0001815",
"name": "mf",
"pos": [
54,
56
]
} |
the results of these studies taken together demonstrate that bone marrow collagen-producing cells from mpd patients with and without mf behave in vitro as do those from normals . | NA | {
"id": "C0027022",
"name": "mpd",
"pos": [
103,
106
]
} | {
"id": "C0001815",
"name": "mf",
"pos": [
133,
135
]
} |
there were no changes observed in the other amino acids as compared to normal , although the glycine and histidine in the erythrocyte showed slight increases . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
44,
55
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
93,
100
]
} |
culture studies of peripheral blood mononuclear cells from 7 entirely typical cases of hairy cell leukemia showed that after culture in the presence of pha for 2 -- 5 days , the predominant cell type changed from e- sig+ cig+ gamma fcr+ mufcr+ hairy cells to an e+ sig- cig- gamma fcr-mufcr- population of transformed cells derived from hairy cells . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
19,
53
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
343,
348
]
} |
this standardized plasma prekallikrein amidolytic assay should facilitate studies of plasma prekallikrein concentration in physiologic and pathologic conditions and help identify activation of the contact phase of coagulation in disease states . | NA | {
"id": "C0030660",
"name": "pathologic conditions",
"pos": [
139,
160
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
229,
236
]
} |
the fetal progenitor cells were more sensitive to appropriate stimuli ( erythropoietin and colony-stimulating factor ) than adult progenitor cells grown under the same conditions , and this was shown to be due to intrinsic differences in the progenitor cells at the different developmental stages . | NA | {
"id": "C0014822",
"name": "erythropoietin",
"pos": [
72,
86
]
} | {
"id": "C0009392",
"name": "colony-stimulating factor",
"pos": [
91,
116
]
} |
the order of effectiveness of guanine nucleotides was guanosine 5'-0- ( 3-thiotriphosphate ) ( gtp-gamma-s ) , 5'-guanylylimido diphosphate ( gpp ( nh ) p ) , and guanosine 5'-triphosphate ( gtp ) . | NA | {
"id": "C0018328",
"name": "guanine nucleotides",
"pos": [
30,
49
]
} | {
"id": "C0018353",
"name": "guanosine",
"pos": [
163,
172
]
} |
the order of effectiveness of guanine nucleotides was guanosine 5'-0- ( 3-thiotriphosphate ) ( gtp-gamma-s ) , 5'-guanylylimido diphosphate ( gpp ( nh ) p ) , and guanosine 5'-triphosphate ( gtp ) . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
142,
154
]
} | {
"id": "C0018353",
"name": "guanosine",
"pos": [
163,
172
]
} |
gtp stimulated enzyme activity without a noticeable lag period , while stimulation by gpp ( nh ) p showed a lag period of 3-4 min . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
0,
3
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
86,
98
]
} |
fifty bronchopulmonary tumors were studied by light and electron microscopy : 39 carcinomas ( 25 small cell carcinomas , 8 undifferentiated carcinomas , 6 poorly differentiated squamous cell carcinomas ) and 11 carcinoid tumors ( 5 central , 4 peripheral , 1 atypical , 1 of the tumorlet type ) . | NA | {
"id": "C0007097",
"name": "carcinomas",
"pos": [
81,
91
]
} | {
"id": "C0262584",
"name": "small cell carcinomas",
"pos": [
97,
118
]
} |
1 the effects of adenosine , 5'-n-ethylcarboxamidoadenosine ( neca ) , 2-chloroadenosine , 2-azidoadenosine , and their l-enantiomers were examined on driven left atria , trachea and transmurally stimulated ileum of the guinea-pig . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
17,
26
]
} | {
"id": "C0050789",
"name": "5",
"pos": [
29,
30
]
} |
1 the effects of adenosine , 5'-n-ethylcarboxamidoadenosine ( neca ) , 2-chloroadenosine , 2-azidoadenosine , and their l-enantiomers were examined on driven left atria , trachea and transmurally stimulated ileum of the guinea-pig . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
17,
26
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
71,
88
]
} |
2 in each tissue the order of potency of the d-enantiomers for producing inhibitory effects was neca greater than 2-chloroadenosine greater than 2-azidoadenosine greater than adenosine . | NA | {
"id": "C0050789",
"name": "neca",
"pos": [
96,
100
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
175,
184
]
} |
in concentrations above 10 ( -7 ) m noradrenaline , 10 ( -6 ) m adrenaline and 10 ( -5 ) dopamine , darkening of subpopulations of melanophores occurred . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
36,
49
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
64,
74
]
} |
3 alpha-msh dose-response curves were shifted , in parallel , to the right in the presence of the catecholamines , noradrenaline , adrenaline and dopamine , and lineweaver-burke plots and arunlakshana-schild plots indicated that the catecholamines antagonized msh action by a competitive mechanism . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
115,
128
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
131,
141
]
} |
4 morphine ( 5 x 10 ( -6 ) m ) as well as the opioid peptides d-ala2 , n-phe4 , met- ( 0 ) -01 ( fk 33-824 ; 9 x 10 ( -7 ) m ) , d-met2-pro5 enkephalin ( 3 x 10 ( -7 ) m ) and d-ala2-d-leu5-enkephalin ( 5 x 10 ( -6 ) m ) inhibited the magnitude of the noncholinergic contracture but did not alter contractile responses to exogenous substance p ( 4 x 10 ( -11 ) m -- 4 x 10 ( -10 ) m ) . | NA | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
46,
61
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
190,
200
]
} |
2 the effects of these compounds on alpha-adrenoceptors were evaluated by examining their ability to reduce alpha 1-stimulated k+ release from rat parotid slices and to displace [ 3h ] -phentolamine from human platelet membrane alpha 2-adrenoceptors . | NA | {
"id": "C0034784",
"name": "alpha-adrenoceptors",
"pos": [
36,
55
]
} | {
"id": "C0001639",
"name": "alpha",
"pos": [
228,
233
]
} |
owing to the continuing controversy regarding the appropriate therapeutic management of asymptomatic , uncomplicated and mild ( 'biochemical ' ) primary hpt , we further evaluated this surgical experience by comparing the results of operation in two groups of patients : those with 'biochemical ' hpt ( serum calcium less than 11 mg/dl ) and those with 'non-biochemical ' hpt ( symptomatic or complicated disease or serum calcium greater than 11 mg/dl ) . | NA | {
"id": "C0221002",
"name": "primary hpt",
"pos": [
145,
156
]
} | {
"id": "C0020502",
"name": "hpt",
"pos": [
372,
375
]
} |
no significant changes were observed in total of ldl cholesterol concentrations , but hdl : ldl ratios and hdl cholesterol as a proportion of total cholesterol fell significantly . | NA | {
"id": "C0023824",
"name": "in",
"pos": [
37,
39
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
148,
159
]
} |
of the remainder , 499 ( 83.0 % ) fulfilled diagnostic criteria for bulimia nervosa , a recently described eating disorder . | NA | {
"id": "C2267227",
"name": "bulimia nervosa",
"pos": [
68,
83
]
} | {
"id": "C0013473",
"name": "eating disorder",
"pos": [
107,
122
]
} |
the mean concentration of total cholesterol also fell significantly as a result of the decrease of high-density lipoprotein cholesterol and of a not significant decrease of low-density lipoprotein cholesterol . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
32,
43
]
} | {
"id": "C0023824",
"name": "low-density lipoprotein cholesterol",
"pos": [
173,
208
]
} |
the fluctuations in the concentration of serum lipids and lipoproteins in 10 women not using oral contraceptives were smaller than in the women using oral contraceptives and no significant changes in the concentrations were found during one cycle . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
47,
53
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
58,
70
]
} |
in a comparative study of oral cholecystography and cholecystosonography six out of 14 patients with gall stones achieving complete success by oral cholecystographic criteria had stones still detectable by ultrasonography . | NA | {
"id": "C0008350",
"name": "gall",
"pos": [
101,
105
]
} | {
"id": "C0006736",
"name": "stones",
"pos": [
179,
185
]
} |
the recent availability of stable adenosine analogues such as cyclohexyladenosine , 2-chloroadenosine and diethylphenylxanthine has made the characterization of such a receptor feasible . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
34,
43
]
} | {
"id": "C0000275",
"name": "2-chloroadenosine",
"pos": [
84,
101
]
} |
the barbiturates were found to stabilize the haeme moiety of haemoglobin preventing its conversion to methaemoglobin in the presence of hydrogen peroxide . | NA | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
61,
72
]
} | {
"id": "C0025635",
"name": "methaemoglobin",
"pos": [
102,
116
]
} |
the maltose group showed a smaller increase in blood sugar level than the glucose group immediately after the completion of infusion . | NA | {
"id": "C0005802",
"name": "in blood sugar",
"pos": [
44,
58
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
74,
81
]
} |
the effects of imidazole-4-acetic acid ( ima , 100 -- 400 mg/kg ) on indole amine metabolism were studied by measurement of the cerebral hemisphere and brain stem contents of tryptophan , 5-hydroxytryptophan ( 5-htp ) , 5-hydroxytryptamine ( 5-ht ) , and 5-hydroxyindoleacetic acid ( 5-hiaa ) . | NA | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
175,
185
]
} | {
"id": "C0000578",
"name": "5-htp",
"pos": [
210,
215
]
} |
the similar change in histone acetylation indicates a possible link between nucleoproteins and chromatin function during ischemic insult to the heart . | NA | {
"id": "C0028612",
"name": "nucleoproteins",
"pos": [
76,
90
]
} | {
"id": "C0008546",
"name": "chromatin",
"pos": [
95,
104
]
} |
all the substituted imidazolines were two to three orders more potent in inhibiting the binding of [ 3h ] clonidine than they were against [ 3h ] wb-4101 . | NA | {
"id": "C1449836",
"name": "imidazolines",
"pos": [
20,
32
]
} | {
"id": "C0009014",
"name": "clonidine",
"pos": [
106,
115
]
} |
the present study describes the effect of chronic estrogen treatment on striatal dopamine levels and dopamine receptors , as well as on apomorphine-induced circling , a behavioral model reflecting dopaminergic activity in the rat striatum . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
81,
89
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
197,
209
]
} |
basal cell carcinoma is the most easily cured carcinoma , but because of the many forms it can take , and because it grows so slowly , it can be misdiagnosed or neglected . | NA | {
"id": "C0007117",
"name": "basal cell carcinoma",
"pos": [
0,
20
]
} | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
46,
55
]
} |
the ultrastructure of one tumor was that of a cellular angioma and the second tumor a vascular lesion with fibroblasts and histiocyte-like mononuclear cells . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
26,
31
]
} | {
"id": "C0085183",
"name": "second tumor",
"pos": [
71,
83
]
} |
this particular translocation has been associated with a better prognosis than have other types of chromosomal abnormalities in patients with anll . | NA | {
"id": "C0040715",
"name": "translocation",
"pos": [
16,
29
]
} | {
"id": "C0008626",
"name": "of chromosomal abnormalities",
"pos": [
96,
124
]
} |
to determine whether the in vivo production of antibodies against choriogonadotropin ( cg ) could modify the relationship between host and malignant growth , the effects of preimmunization with a conjugate of the beta-subunit of cg and tetanus toxoid ( cg beta-tt ) on the development and growth of lung metastasis following i.v . injection of r 3230 rat mammary adenocarcinoma cells into fischer 344 female rats have been investigated . | NA | {
"id": "C0018062",
"name": "choriogonadotropin",
"pos": [
66,
84
]
} | {
"id": "C0106132",
"name": "beta-subunit",
"pos": [
213,
225
]
} |
because of structural similarities between melphalan ( l-pam ) and peptichemio a prospective randomized study was done to compare the therapeutic efficacy of these two agents . | NA | {
"id": "C0025241",
"name": "l-pam",
"pos": [
55,
60
]
} | {
"id": "C0030927",
"name": "peptichemio",
"pos": [
67,
78
]
} |
after failing various combinations of doxorubicin , cyclophosphamide , fluorouracil , methotrexate , and vincristine patients with advanced breast cancer were randomized to receive either peptichemio or l-pam . | NA | {
"id": "C0030927",
"name": "peptichemio",
"pos": [
188,
199
]
} | {
"id": "C0025241",
"name": "l-pam",
"pos": [
203,
208
]
} |
peptichemio was administered at 75-100 mg/m2 and l-pam at 30-40 mg/m2 iv q 3-4 week interval . | NA | {
"id": "C0030927",
"name": "peptichemio",
"pos": [
0,
11
]
} | {
"id": "C0025241",
"name": "l-pam",
"pos": [
49,
54
]
} |
in conclusion , peptichemio is an active agent in advanced breast cancer , but l-pam is ineffective in previously treated patients with metastatic breast cancer . | NA | {
"id": "C0030927",
"name": "peptichemio",
"pos": [
16,
27
]
} | {
"id": "C0025241",
"name": "l-pam",
"pos": [
79,
84
]
} |
though catabolically active , these cells degraded non-maa surface macromolecules shed by themselves or by allogeneic cells much more rapidly than they inactivated maas . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
36,
41
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
107,
123
]
} |
these am acquired enhanced capacity to kill tumor cells following a 24-hr incubation in vitro with endotoxin [ lipopolysaccharide ( lps ) ] . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
99,
108
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
111,
129
]
} |
hepatocellular altered foci were induced in rat liver by cycles of feeding of n-2-fluorenylacetamide and were distinguished by their resistance to iron accumulation following production of hepatic siderosis by dietary administration of 8-hydroxyquinoline and ferrous gluconate . | NA | {
"id": "C0302583",
"name": "iron",
"pos": [
147,
151
]
} | {
"id": "C0060277",
"name": "ferrous gluconate",
"pos": [
259,
276
]
} |
when culture conditions were modulated , the first culture , l 428 , gave rise to two sublines : l 428 ks , after adaptation to calf serum , and l 428 ksa , permanently growing as an adherent monolayer line after treatment with a phorbol ester ( 12-o-tetradecanoylphorbol-13-acetate ) for 3 weeks . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
230,
243
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
246,
282
]
} |
abvd combined with radiotherapy in 153 patients with stage iib , iiia , or iiib disease was superior to mopp plus radiotherapy in the cr induction ( 94 % vs 79 % , p less than 0.01 ) , particularly in the presence of nodular sclerosis histology ( p less than 0.03 ) and b symptoms ( p = 0.01 ) , as well as in the relapse-free survival of patients with pathologic stage iiia disease ( abvd , 100 % ; mopp , 68 % ; p = 0.02 ) . | NA | {
"id": "C0012634",
"name": "disease",
"pos": [
80,
87
]
} | {
"id": "C0030660",
"name": "pathologic",
"pos": [
353,
363
]
} |
the value of the dipyridamole test ( 0.75 mg/kg i.v . ) in the diagnosis of angina pectoris was studied in 54 patients with angina pectoris ( 35 with angina on effort associated or not associated with rest angina and 19 with angina only at rest ) and in 12 control subjects . | NA | {
"id": "C0002965",
"name": "rest angina",
"pos": [
201,
212
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
225,
231
]
} |
approximately 10 % of the rna labeled in vitro contained poly ( a ) , and the length of poly ( a ) was very similar to that of nuclear rna isolated from ad2-infected cells . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
26,
29
]
} | {
"id": "C0035700",
"name": "nuclear",
"pos": [
127,
134
]
} |
the results suggest that specific double-stranded dna sequences are recognized by the oviduct progesterone-receptor complex in vitro , and are relevant to the question of whether specific dna sequences are directly involved as genomic binding sites for steroid receptors . | NA | {
"id": "C0034833",
"name": "progesterone-receptor",
"pos": [
94,
115
]
} | {
"id": "C0034840",
"name": "steroid receptors",
"pos": [
253,
270
]
} |
these findings implicate heparan and chondroitin sulfate proteoglycans as integral compounds of the pericellular matrix fibers and suggest that the association of the proteoglycans with the fibronectin-procollagen matrix is stabilized by multiple molecular interactions . | NA | {
"id": "C0033689",
"name": "chondroitin sulfate proteoglycans",
"pos": [
37,
70
]
} | {
"id": "C0033692",
"name": "proteoglycans",
"pos": [
167,
180
]
} |
[ separation and purification of antithrombin iii , thrombin and carboxypeptidase n using affinity sorption on the copolymer hydroxyalkylmethacrylate with immobilized heparin ( heparinoid ) ] . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
167,
174
]
} | {
"id": "C0019142",
"name": "heparinoid",
"pos": [
177,
187
]
} |
in vivo experiments with e. coli b have demonstrated that hcg extensively breaks down bacterial dna and interacts with the synthesis of cellular dna to the similar extent as found for n-methyl-n'-nitro-n-nitrosoguanidine ( mnng ) . | NA | {
"id": "C0012924",
"name": "bacterial dna",
"pos": [
86,
99
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
145,
148
]
} |
early administration of mp or ib retarded the development of myocardial fibrosis , pericarditis and pericardial effusion , and improved survival in this experimental model of radiation-induced heart disease . | NA | {
"id": "C0031039",
"name": "pericardial effusion",
"pos": [
100,
120
]
} | {
"id": "C0018799",
"name": "of",
"pos": [
172,
174
]
} |
the effects of age , body wight and family relationships on plasma lipoproteins and lipids in men , women and children of randomly selected families . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
67,
79
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
84,
90
]
} |
it occurred most often in patients with angina at rest and less often in patients with angina both at rest and induced by exercise . | NA | {
"id": "C0002965",
"name": "angina at rest",
"pos": [
40,
54
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
87,
93
]
} |
in patients with rt using a concealed ap , but not in those with reentry within the av node , coexisting diminished physiologic av conduction slowing may be associated with more rapid tachycardia rates . | NA | {
"id": "C0242514",
"name": "rt",
"pos": [
17,
19
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
184,
195
]
} |
at follow-up , 11 patients had minimal or no angina pectoris ( group 1 ) , and eight patients had worsening angina or recurrent unstable angina ( group 2 ) . | NA | {
"id": "C0002962",
"name": "angina pectoris",
"pos": [
45,
60
]
} | {
"id": "C0002965",
"name": "unstable angina",
"pos": [
128,
143
]
} |
simultaneous fluorometry of urinary dopamine , norepinephrine , and epinephrine compared with liquid chromatography with electrochemical detection . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
47,
61
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
68,
79
]
} |
a simple fluorometric method is described for simultaneous assay of urinary norepinephrine , epinephrine , and dopamine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
76,
90
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
93,
104
]
} |
values for urinary dopamine , norepinephrine , and epinephrine agreed with those obtained by `` '' high-performance '' '' liquid chromatography with electrochemical detection . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
30,
44
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
51,
62
]
} |
a `` '' high-performance '' '' liquid-chromatographic separation of retinoids ( retinol , isotretinoin , all-trans retinoic acid , retinal , etretinate , and retinyl acetate ) in serum is described . | NA | {
"id": "C0035339",
"name": "f retinoi",
"pos": [
66,
75
]
} | {
"id": "C0022265",
"name": "isotretino",
"pos": [
90,
100
]
} |
the proteins identified in human milk patterns include the alpha and beta casein families , lactalbumin , albumin , transferrin , iga , and lactoferrin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
4,
12
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
106,
113
]
} |
the proteins identified in human milk patterns include the alpha and beta casein families , lactalbumin , albumin , transferrin , iga , and lactoferrin . | NA | {
"id": "C0022912",
"name": "lactalbumin",
"pos": [
92,
103
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
106,
113
]
} |
with this technique , the myelin proteins ( myelin basic protein , proteolipids , and basic wolfgram proteins ) and many other unindentified major basic proteins can be demonstrated . | NA | {
"id": "C0026972",
"name": "myelin",
"pos": [
26,
32
]
} | {
"id": "C0014063",
"name": "myelin basic protein",
"pos": [
44,
64
]
} |
we encountered difficulties in detecting trace proteins , due to masking effects of such major serum-protein constituents as albumin . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
47,
55
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
125,
132
]
} |
we examined the various steps of the analysis in detail for reproducibility and protein loss , using radiolabeled albumin , alpha 2-macroglobulin , and beta 2-microglobulin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
80,
87
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
114,
121
]
} |
we resolved the [ 35s ] methionine polypeptides synthesized by normal [ lung fibroblasts ( wi-38 ) , amnion cells ] and transformed [ sv40 transformed wi-38 , ama ( spontaneously transformed amnion cells ) ] cultured human cells , using two-dimensional gel electrophoresis under conditions in which about 1300 polypeptides could be reproducibly separated . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
77,
88
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
223,
228
]
} |
similar but qualitative studies of [ 32p ] orthophosphate-labeled proteins revealed that , of 250 analyzed , only seven common phosphoproteins , including phosphovimentin ( ief 26e ) , varied consistently in both cell pairs . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
66,
74
]
} | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
127,
142
]
} |
in contrast , the fibroblast cytoskeletal protein pattern contained four groups of proteins that differed from the patterns of the leukocytes and gm607 . | NA | {
"id": "C0010852",
"name": "cytoskeletal protein",
"pos": [
29,
49
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
83,
91
]
} |
the porphyrinic patients examined , and some of their relatives , showed a characteristic pattern of porphyrin production , with high uroporphyrin/coproporphyrin and ( uroporphyrin + heptacarboxylic porphyrins ) /coproporphyrin ratios , at least partly ascribable to increased uroporphyrinogen i synthetase ( ec 4.2.1.8 ) activity in patients ' hemolysates , and also to a relative deficiency of uroporphyrinogen decarboxylase . | NA | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
4,
13
]
} | {
"id": "C0042093",
"name": "uroporphyrin",
"pos": [
396,
408
]
} |
the porphyrinic patients examined , and some of their relatives , showed a characteristic pattern of porphyrin production , with high uroporphyrin/coproporphyrin and ( uroporphyrin + heptacarboxylic porphyrins ) /coproporphyrin ratios , at least partly ascribable to increased uroporphyrinogen i synthetase ( ec 4.2.1.8 ) activity in patients ' hemolysates , and also to a relative deficiency of uroporphyrinogen decarboxylase . | NA | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
4,
13
]
} | {
"id": "C0009988",
"name": "coproporphyrin",
"pos": [
213,
227
]
} |
the method is based on ( a ) hydrolysis of cholesterol esters to cholesterol by cholesterol ester hydrolase ( ec 3.1.1.13 ) , ( b ) oxidation of cholesterol to cholest-4-en-4-one and hydrogen peroxide by cholesterol oxidase ( ec 1.1.3.6 ) , and ( c ) oxidation of a triarylimidazole leuco dye with hydrogen peroxide in the presence of peroxidase ( ec 1.11.1.7 ) to produce a dye with maximum absorption at about 650 nm . | NA | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
43,
61
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
204,
215
]
} |
sodium results for urine with the beckman electrolyte 2 ion-selective electrolyte analyzer are dependent on potassium concentration . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
42,
53
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
128,
131
]
} |
progesterone is then assayed by using an antiserum to a progesterone 11 alpha hemisuccinyl conjugate and the radioligand 125i-labeled progesterone 11 alpha-glucuronyl tyramine , with separation by double-antibody techniques . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
41,
50
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
204,
212
]
} |
this fluoroimmunoassay for digitoxin in serum involves use of a sheep antiserum to digitoxin coupled to magnetizable solid-phase particles and fluorescein-labeled 3-o-succinyl digitoxigenin as tracer . | NA | {
"id": "C0012258",
"name": "digitoxin",
"pos": [
27,
36
]
} | {
"id": "C0012257",
"name": "digitoxigenin",
"pos": [
176,
189
]
} |
collection of the cells of washing and amino acid measurement is further complicated by the adherence of cultured fibroblasts to the culture vessel surface . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
18,
23
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
114,
125
]
} |
serum levels of the delta 5 3 beta-hydroxysteroids , pregnenolone ( pe ) , 17 alpha-hydroxypregnenolone ( 17pe ) , dehydroepiandrosterone ( dhea ) and androstenediol ( adiol ) and their delta 4 3-keto counterparts , progesterone ( po ) , 17 alpha-hydroxyprogesterone ( 17po ) androstenedione ( adione ) and testosterone as well as of 11-deoxycortisol and cortisol were measured during acute adrenal suppression with dexamethasone followed by stimulation with synthetic 1-24 acth . | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
53,
65
]
} | {
"id": "C0376260",
"name": "17 alpha-hydroxypregnenolone",
"pos": [
75,
103
]
} |
during hyperprolactinaemia ( group 2 ) the responses of pregnenolone , progesterone , 17-hydroxyprogesterone , testosterone and 5 alpha-dihydrotestosterone tended to be greater than in the control and hypoprolactinaemia groups , but these changes were not statistically significant . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
71,
83
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
86,
108
]
} |
a review of the absorption , distribution , metabolism and excretion of ticrynafen ( tienilic acid ) in 8 animal species , including man , is presented . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
44,
54
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
59,
68
]
} |
characterization of the ( post-thymic ) precursor cells ( derived from normal donors ) with the aid of monoclonal antibodies of the okt series and several other markers pointed out that this population contains okt4+ as well as okt8+ cells . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
40,
55
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
234,
239
]
} |
since ra sera after precipitation with 2.5 % polyethyleneglycol , still showed cytotoxicity against t and b lymphocytes , it is suggested that this serum reactivity is not caused by immune complexes but by antibodies . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
182,
198
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
206,
216
]
} |
removal of plastic and nylon-wool-adherent cells resulted in cell preparations ( morphologically 80 % lymphoid ) with increased cytolytic activity against k562 but cytotoxicity levels were considerably lower than those of blood lymphocytes tested in parallel . | NA | {
"id": "C0032167",
"name": "plastic",
"pos": [
11,
18
]
} | {
"id": "C0028736",
"name": "nylon",
"pos": [
23,
28
]
} |
it was concluded that insulin resistance probably caused the defective triglyceride removal , and that both decreased removal and increased production of triglycerides contributed to the hyperlipidemia in dialysis patients . | NA | {
"id": "C0020557",
"name": "increased",
"pos": [
130,
139
]
} | {
"id": "C0020473",
"name": "hyperlipidemia",
"pos": [
187,
201
]
} |
weaning , male rats were given ethane-1-hydroxy 1,1-diphosphonate ( ehdp ) or dichloromethylene diphosphonate ( cl2mdp ) 0.5 mgp/kg/day for 140 days . | NA | {
"id": "C0012544",
"name": "diphosphonate",
"pos": [
52,
65
]
} | {
"id": "C0012081",
"name": "cl2mdp",
"pos": [
112,
118
]
} |
many of the drugs used in the treatment of the adult epilepsies , including phenytoin , phenobarbitone , primidone and carbamazepine , are potent inducers of the hepatic microsomal enzymes . | NA | {
"id": "C0031412",
"name": "phenobarbitone",
"pos": [
88,
102
]
} | {
"id": "C0033148",
"name": "primidone",
"pos": [
105,
114
]
} |
in omaha , from 1974 to 79 , 30 ( 12.5 % ) of 240 patients with haemophilus influenzae bacteremia or meningitis had a wide variety of conditions known to be associated with increased susceptibility to bacterial infection . | NA | {
"id": "C0004610",
"name": "bacteremia",
"pos": [
87,
97
]
} | {
"id": "C0004623",
"name": "bacterial infection",
"pos": [
201,
220
]
} |
salicylate appeared to displace vpa from serum albumin in vivo , but the increased vpa t1/2 and changes in vpa elimination patterns suggest that serum salicylate also altered vpa metabolism . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
111,
122
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
179,
189
]
} |
the digoxigenin route of digoxin biotransformation to polar metabolites may be important in some patients receiving digoxin and such metabolites could contribute an important fraction to the serum digoxin concentration measured by radioimmunoassay . | NA | {
"id": "C0012264",
"name": "digoxigenin",
"pos": [
4,
15
]
} | {
"id": "C0012265",
"name": "digoxin",
"pos": [
197,
204
]
} |
it can then pass up into the neck to produce widespread subcutaneous emphysema and down through the diaphragmatic hiatuses to produce extraperitoneal emphysema . | NA | {
"id": "C0038536",
"name": "subcutaneous emphysema",
"pos": [
56,
78
]
} | {
"id": "C0013990",
"name": "emphysema",
"pos": [
150,
159
]
} |
at the same time there was a gradual increase of plasma levels of renin , angiotension ii , aldosterone , noradrenaline and adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
106,
119
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
124,
134
]
} |
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