text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
the major isoenzymes of human hexosaminidase have the structures alpha beta 2 ( hex a ) and 2 beta 2 ( hex b ) . | NA | {
"id": "C0005270",
"name": "hexosaminidase",
"pos": [
30,
44
]
} | {
"id": "C0162330",
"name": "hex a",
"pos": [
80,
85
]
} |
the major isoenzymes of human hexosaminidase have the structures alpha beta 2 ( hex a ) and 2 beta 2 ( hex b ) . | NA | {
"id": "C0005270",
"name": "hexosaminidase",
"pos": [
30,
44
]
} | {
"id": "C0019481",
"name": "hex b",
"pos": [
103,
108
]
} |
the antigen in crude bacterial lysates is a satisfactory diagnostic reagent for antibodies to the core antigen in serum samples . | NA | {
"id": "C0003321",
"name": "antigen",
"pos": [
4,
11
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
103,
110
]
} |
restriction endonuclease mapping indicated that the dna present in the carcinomas was of the same type ( type 5 ) as that found in the benign tumors from these patients and was present as unintegrated , free viral dna . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
52,
55
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
208,
217
]
} |
administration of naloxone or naltrexone in dba/2 ( dba ) mice was followed by dose related depressant effects . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
18,
26
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
30,
40
]
} |
the results are discussed in terms of differences in type number and/or distribution of the receptors influenced by naloxone and naltrexone in the two strains of mice tested . | NA | {
"id": "C0027358",
"name": "naloxone",
"pos": [
116,
124
]
} | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
129,
139
]
} |
this result is due to the action of antibodies to gm1 ganglioside since the specific removal of these antibodies from the antiserum with pure gm1 ganglioside eliminates the blocking activity . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
36,
46
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
122,
131
]
} |
naltrexone and naloxone , but not sulpiride , significant increased grooming and grooming invitations while aggressive behaviour , self grooming , scratching and general locomotor activity were unaffected . | NA | {
"id": "C0027360",
"name": "naltrexone",
"pos": [
0,
10
]
} | {
"id": "C0027358",
"name": "naloxone",
"pos": [
15,
23
]
} |
surface depositions of isotope were attempted by introducing a radionuclide into solution which was in equilibrium with trabecular bone and depositions approximating to an 'infinitely ' thin layer of isotope were achieved for 32p and 14c using adenosine triphosphate-labelled molecules . | NA | {
"id": "C0034595",
"name": "radionuclide",
"pos": [
63,
75
]
} | {
"id": "C0022262",
"name": "isotope",
"pos": [
200,
207
]
} |
iliofemoral and iliocaval phlebitis , however , involve considerable risk as they may endanger life ( pulmonary embolism ) , limb ( ischemic forms ) or the functioning of the limb ( severe post-phlebitic syndromes ) . | NA | {
"id": "C0031542",
"name": "phlebitis",
"pos": [
26,
35
]
} | {
"id": "C0032807",
"name": "post-phlebitic syndromes",
"pos": [
189,
213
]
} |
haemorrhage , haematoma , swelling , oedema , lymphatic deep vein thrombosis , pulmonary embolism ( 1 in 3000 -- fatal 1 in 30,000 ) . | NA | {
"id": "C0019080",
"name": "haemorrhage",
"pos": [
0,
11
]
} | {
"id": "C0018944",
"name": "haematoma",
"pos": [
14,
23
]
} |
on the other hand , tetracosactide ( beta 1-24-corticotropin ) revealed the smallest stimulatory effect on the preparation from 5-day-old rats ; | NA | {
"id": "C0010192",
"name": "tetracosactide",
"pos": [
20,
34
]
} | {
"id": "C0001655",
"name": "corticotropin",
"pos": [
47,
60
]
} |
in order to estimate the possible changes of the functional state of beta-adrenergic receptors during ontogenesis , the lipid mobilizing effects of isoprenaline ( iso ) , adrenaline ( adr ) and noradrenaline ( na ) were studied in trimmed subcutaneous adipose tissue of rats at different stages of postnatal development ( 5 , 14 , 21 and 35 days after birth . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
171,
181
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
194,
207
]
} |
the calculated pd2 values indicate the same potency order iso much greater than na = adr in all age groups and they also demonstrate that there exist no appreciable differences in the affinity single catecholamines at different stages of postnatal development . | NA | {
"id": "C0022245",
"name": "iso",
"pos": [
58,
61
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
200,
214
]
} |
the calculated pd2 values indicate the same potency order iso much greater than na = adr in all age groups and they also demonstrate that there exist no appreciable differences in the affinity single catecholamines at different stages of postnatal development . | NA | {
"id": "C0028351",
"name": "na",
"pos": [
80,
82
]
} | {
"id": "C0014563",
"name": "adr",
"pos": [
85,
88
]
} |
the in vitro release of free fatty acids from small adipocytes ( mean diameter 24.4 +/- 0.4 micrometer ; 11-42 micrometer ) isolated from subcutaneous adipose tissue of rats aged 5 , 14 , 21 and 35 days was induced by l-isoprenaline ( iso ) , l-noradrenaline ( na ) or l-adrenaline ( adr ) . | NA | {
"id": "C0028351",
"name": "l-noradrenaline",
"pos": [
243,
258
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
271,
281
]
} |
in adult rats , increasing catecholamine ( ca ) concentrations produced pronounced concentration-dependent lipolysis in the potency order iso greater than na greater than adr which is typical of beta 1-adrenergic functions . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
27,
40
]
} | {
"id": "C0022245",
"name": "iso",
"pos": [
138,
141
]
} |
in adult rats , increasing catecholamine ( ca ) concentrations produced pronounced concentration-dependent lipolysis in the potency order iso greater than na greater than adr which is typical of beta 1-adrenergic functions . | NA | {
"id": "C0028351",
"name": "na",
"pos": [
155,
157
]
} | {
"id": "C0014563",
"name": "adr",
"pos": [
202,
205
]
} |
electron microscopy showed active contractile fibroblasts ( myofibroblasts ) in the lower two zones in skin/nodule , with clusters of active and degenerating cells side by side . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
46,
57
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
158,
163
]
} |
gender contributed no significant differences to heart rate , but females at risk for sids had lower waking cardiac variability than males . | NA | {
"id": "C0079399",
"name": "gender",
"pos": [
0,
6
]
} | {
"id": "C0086582",
"name": "males",
"pos": [
133,
138
]
} |
aggregation started 45 -- 60 min after the addition of glucose or sucrose whereas slowly metabolized sugars as galactose and lactose required several hours to cause aggregation . | NA | {
"id": "C0038636",
"name": "sucrose",
"pos": [
66,
73
]
} | {
"id": "C0242209",
"name": "sugars",
"pos": [
101,
107
]
} |
inhibition of microbial enzymes in human dental plaque catalyzing the cleavage of the disaccharides maltose , sucrose and lactose was carried out with the alpha-glucosidase inhibitor , acarbose . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
86,
99
]
} | {
"id": "C0024658",
"name": "maltose",
"pos": [
100,
107
]
} |
inhibition of microbial enzymes in human dental plaque catalyzing the cleavage of the disaccharides maltose , sucrose and lactose was carried out with the alpha-glucosidase inhibitor , acarbose . | NA | {
"id": "C0012611",
"name": "disaccharides",
"pos": [
86,
99
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
110,
117
]
} |
the benefit of semiannual application of the sodium fluoride varnish duraphat and the silane fluoride varnish fluor protection was studied in 11 -- 13-year-old children with high caries activity and life-long exposure to fluoridated drinking water ( 1 -- 1.2 parts/10 ( 6 ) ) . | NA | {
"id": "C0037508",
"name": "sodium fluoride",
"pos": [
45,
60
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
93,
101
]
} |
the formation of fibroblastoid colonies by marrow cells in vitro has been used as a putative assay for a stem cell of haemopoietic stroma . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
50,
55
]
} | {
"id": "C0018956",
"name": "stem cell",
"pos": [
105,
114
]
} |
counter-electrophoresis showed antibodies to the ss-b antigen in sera from patients with rheumatic diseases , including rheumatoid arthritis , systemic lupus erythematosus and sjogren 's syndrome , but not in amy of the control sera . | NA | {
"id": "C0003873",
"name": "rheumatoid",
"pos": [
120,
130
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
176,
195
]
} |
sixteen healthy siblings were identified as hla-d-identical to 12 borderline lepromatous or polar lepromatous leprosy patients by the absence of a mixed lymphocyte reaction ( mlr ) . | NA | {
"id": "C1562585",
"name": "borderline",
"pos": [
66,
76
]
} | {
"id": "C0023348",
"name": "lepromatous leprosy",
"pos": [
98,
117
]
} |
the advantages of this assay are that it measures concentrations of single epitopes , purified antigen is not required , and the reagents can be obtained in unlimited amounts and are homogeneous . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
75,
83
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
95,
102
]
} |
the calcium increase occurs 5 to 6 weeks ( passages ) earlier and is significantly greater in fibroblasts from subjects with cystic fibrosis in comparison with cells from control subjects . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
94,
105
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
160,
165
]
} |
echocardiography was used to evaluate left ventricular function in 43 consecutive patients with suspected cor pulmonale who clinically had no other heart disease or hypertension . | NA | {
"id": "C0034072",
"name": "cor pulmonale",
"pos": [
106,
119
]
} | {
"id": "C0018799",
"name": "heart disease",
"pos": [
148,
161
]
} |
we observed the comparative serum levels and mean peak serum antistaphylococcal activity in eight fasting adults who received 500 mg each of dicloxacillin , cloxacillin , oxacillin , and nafcillin . | NA | {
"id": "C0012093",
"name": "dicloxacillin",
"pos": [
141,
154
]
} | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
157,
168
]
} |
we observed the comparative serum levels and mean peak serum antistaphylococcal activity in eight fasting adults who received 500 mg each of dicloxacillin , cloxacillin , oxacillin , and nafcillin . | NA | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
143,
154
]
} | {
"id": "C0029983",
"name": "oxacillin",
"pos": [
171,
180
]
} |
these entities include acute ethanol intoxication , ethanol-induced hypoglycemia , alcoholic ketoacidosis , ethylene glycol and methanol intoxications , thiamine deficiency , and hepatic encephalopathy . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
29,
36
]
} | {
"id": "C0001963",
"name": "methanol",
"pos": [
128,
136
]
} |
regional spinal cord blood flow was measured in 12 halothane-anesthetized mongrel dogs by means of 15 +/- 3 u radiolabeled microspheres under ( 1 ) control conditions , ( 2 ) 60-torr mean arterial blood pressure ( map ) using sodium nitroprusside ( nps ) , ( 3 ) 50-torr map using nps , and ( 4 ) after reestablishment of normotension . | NA | {
"id": "C0037533",
"name": "sodium",
"pos": [
226,
232
]
} | {
"id": "C0028193",
"name": "nps",
"pos": [
281,
284
]
} |
ischaemic heart disease was the most common underlying cause ( 19 patients ) , with cardiomyopathy ( 9 ) , rheumatic heart disease ( 2 ) , failed transplants ( 3 ) , and endomyocardial fibrosis ( 1 ) as the other causes of myocardial disease . | NA | {
"id": "C0878544",
"name": "cardiomyopathy",
"pos": [
84,
98
]
} | {
"id": "C0553980",
"name": "endomyocardial",
"pos": [
170,
184
]
} |
terbutaline sulphate ( bricanyl ; keatings ) aerosol or placebo aerosol was administered in a randomized fashion to 26 asthmatic children with proven exercise-induced asthma . | NA | {
"id": "C0004096",
"name": "asthmatic",
"pos": [
119,
128
]
} | {
"id": "C0004099",
"name": "exercise-induced asthma",
"pos": [
150,
173
]
} |
infections causing failure in patients in the cefoxitin group more frequently contained cefoxitin resistant gram-negative rods at the time of failure than did infections causing failure in those in the clindamycin-aminoglycoside group that contained gentamicin-resistant gram-negative rods , eight of eight versus zero of eight , p less than 0.001 . | NA | {
"id": "C0002556",
"name": "aminoglycoside",
"pos": [
214,
228
]
} | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
250,
260
]
} |
the cells of the cyst wall , which rested on a basement membrane , had microvilli and abnormal cilia , and there were desmosomes between the cells , in accordance with the pathological findings , the cyst was classified as a type transitional between a choroidal epithelial cyst and an ependymal cyst . | NA | {
"id": "C0010709",
"name": "cyst",
"pos": [
17,
21
]
} | {
"id": "C0014511",
"name": "epithelial cyst",
"pos": [
263,
278
]
} |
1 % ophthalmic ointment applied twice daily for one week or 0.25 % physostigmine ( eserine ) ointment applied twice daily for a minimum of ten days , to the lid margins should be considered when the total removal of phthirus pubis and nits is not possible mechanically . | NA | {
"id": "C0304651",
"name": "ophthalmic ointment",
"pos": [
4,
23
]
} | {
"id": "C0028912",
"name": "ointment",
"pos": [
93,
101
]
} |
the incidence and grade of differentiation of resulting tumors , as well as the thickness , content of nucleic acids , and specific activity of dna in colonic mucosa , were similar in both high-gastrin and low-gastrin animals and were unchanged from data in unoperated control animals receiving only the carcinogen . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
103,
116
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
144,
147
]
} |
beta-factor xiia ( beta-xiia , mr approximately 30,000 ) was isolated from human plasma by a procedure which utilized , as an initial step , the adsorption of factor xii to celite . | NA | {
"id": "C0015527",
"name": "factor xiia",
"pos": [
5,
16
]
} | {
"id": "C0015525",
"name": "factor xii",
"pos": [
159,
169
]
} |
the present study reports that polylysine can function as a cofactor in the conversion of factor x to factor xa by factor ixa . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
90,
98
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
102,
111
]
} |
in the presence of polylysine , factor x is converted to factor xa by factor ixa as demonstrated by both clotting and amidolytic assays . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
32,
40
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
57,
66
]
} |
the activation of factor x by factor ixa requires the prior activation of factor ix to ixa by factor xia . | NA | {
"id": "C0015491",
"name": "factor ix",
"pos": [
30,
39
]
} | {
"id": "C0015494",
"name": "ixa",
"pos": [
87,
90
]
} |
conversion of factor x to factor xa by factor ixa is not observed in the absence of polylysine . | NA | {
"id": "C0015518",
"name": "factor x",
"pos": [
14,
22
]
} | {
"id": "C0015520",
"name": "factor xa",
"pos": [
26,
35
]
} |
of 20 kinds of plant lectins examined , agglutinin activity of only mushroom lectin was inhibited with non-hemoglobin proteins of the red cell lysate . | NA | {
"id": "C0304052",
"name": "plant lectins",
"pos": [
15,
28
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
77,
83
]
} |
of 20 kinds of plant lectins examined , agglutinin activity of only mushroom lectin was inhibited with non-hemoglobin proteins of the red cell lysate . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
21,
27
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
118,
126
]
} |
glycosaminoglycan isolated from urine of a patient with the hurler-scheie compound syndrome consisted of dermatan sulfate ( 60 % ) , heparan sulfate ( 34 % ) and chondroitin sulfate ( 6 % ) . | NA | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
0,
17
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
133,
148
]
} |
for the treatment of congenital cardiac anomalies associated with hypoplastic right ventricle such as tricuspid atresia , various methods have been used in clinical and experimental studies . | NA | {
"id": "C0018798",
"name": "congenital cardiac anomalies",
"pos": [
21,
49
]
} | {
"id": "C0243002",
"name": "tricuspid atresia",
"pos": [
102,
119
]
} |
metabolism , distribution , and excretion of the flame retardant , tris ( 2,3-dibromopropyl ) phosphate ( tris-bp ) in the rat : identification of mutagenic and nephrotoxic metabolites . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
0,
10
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
32,
41
]
} |
a simple method has been developed using 'sep-pak ' disposable silica cartridges to separate the major endogenous vitamin d metabolites , namely vitamin d3 , 25-hydroxy vitamin d3 ( 25ohd3 ) , 1,25 dihydroxy vitamin d3 ( 1.25 ( oh ) 2d3 ) and 24,25 dihydroxyvitamin d3 ( 24,25 ( oh ) 2d3 ) . | NA | {
"id": "C0006657",
"name": "25-hydroxy vitamin d3",
"pos": [
158,
179
]
} | {
"id": "C2713074",
"name": "25ohd3",
"pos": [
182,
188
]
} |
this is applied to a sep-pak column , and stepwise elution carried out under gravity with 0.1 divided by isopropanol in hexane ( neutral lipids ) , 1 % isopropanol in hexane ( d3 ) , 3 divided by isopropanol in hexane ( 25ohd3 ) , 3.125 divided by ethanol in dichloromethane ( 24,25 ( oh ) 2d3 ) and 50 divided ethanol in toluene ( 1 , 25 ( oh ) 2d3 ) . | NA | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
105,
116
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
311,
318
]
} |
ten healthy male volunteers were treated for seven days with either sulfamethoxazole ( 5 subjects ) or co-trimoxazole ( 5 subjects ) in the usual recommended doses . | NA | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
68,
84
]
} | {
"id": "C0041044",
"name": "co-trimoxazole",
"pos": [
103,
117
]
} |
immunoglobulin classes and igg subclasses of some clinically significant antibodies ( anti-d and anti-cd , anti-fy , anti-jka ) as well as of clinically insignificant anti-chido antibodies were determined . | NA | {
"id": "C0021017",
"name": "immunoglobulin classes",
"pos": [
0,
22
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
178,
188
]
} |
to characterize further lymphomas which arise in chronically immunosuppressed allotransplant patients , we studied the clinical and histological features of seven cases of nonhodgkin 's lymphoma and determined the immunological phenotype in four cases , which developed in a series of 182 patients who underwent cardiac transplantation at stanford university hospital . | NA | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
24,
33
]
} | {
"id": "C0024305",
"name": "nonhodgkin 's lymphoma",
"pos": [
172,
194
]
} |
thus , after the treatment of the inoculum with the monoclonal anti-ly-1.1 antibody and complement , c57bl/6 skin grafts survived indefinitely , whereas ly-2 antibody depletion merely delayed the onset of rejection . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
52,
62
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
158,
166
]
} |
this showed that a ly-1+2- precursor cell rather than a ly-1+2+ cell was the progenitor of the ly-1+2- graft rejection effector cell . | NA | {
"id": "C0018956",
"name": "precursor cell",
"pos": [
27,
41
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
128,
132
]
} |
nevertheless , another t cell subset augmented the rejection of ski grafts and it was concluded that ly-1,2,3+ cells also provided a pool of precursor cells . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
111,
116
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
141,
156
]
} |
thus , it appeared that both ly-1+ and ly-1,2,3+ cells can function as precursor cells for the effector cells , which , as shown previously , have the ly-1+ phenotype . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
49,
54
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
71,
86
]
} |
the ultrastructural resemblance between the epithelial and spindle-shaped cells favors a common cellular origin , the endometrial stromal fibroblast . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
96,
104
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
138,
148
]
} |
the ultrastructure of cultured fibroblasts from 2 hemizygotes with fabry 's disease ad 8 heterozygotes was compared with that of normal cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
31,
42
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
129,
141
]
} |
a contrast variation method is described by which protein and nucleic acid components of nucleoprotein assemblies can be distinguished in the electron microscope . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
50,
57
]
} | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
89,
102
]
} |
a new combination of trimethoprim with a sulphonamide , named kelfiprim , differs from cotrimoxazole in that : a ) the sulpha drug is sulphamethopyrazine instead of sulphamethoxazole ; | NA | {
"id": "C0041044",
"name": "cotrimoxazole",
"pos": [
87,
100
]
} | {
"id": "C0038689",
"name": "sulphamethoxazole",
"pos": [
165,
182
]
} |
the authors believe that the main criterion for choice of the method of treatment of diabetic patients with gangrene of lower extremities is the degree of compensation of blood circulation which was estimated by temperature asymmetry of necrosis on the crus . | NA | {
"id": "C0017086",
"name": "gangrene",
"pos": [
108,
116
]
} | {
"id": "C0027540",
"name": "necrosis",
"pos": [
237,
245
]
} |
results of the operative treatment of 42 patients with fractures of the condylar process complicated by a dislocation of the head are analyzed in different terms after trauma . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
55,
64
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
168,
174
]
} |
xylazine caused hyperglycaemia and glucose intolerance in young rats and the administration of the beta-adrenergic blocker ( propranolol ) prolonged this diabetogenic effect . | NA | {
"id": "C0020456",
"name": "hyperglycaemia",
"pos": [
16,
30
]
} | {
"id": "C0271650",
"name": "glucose intolerance",
"pos": [
35,
54
]
} |
it is supposed on the basis of our results that xylazine-induced glucose intolerance and hyperglycaemia are mediated by the stimulation of the alpha-adrenergic system . | NA | {
"id": "C0271650",
"name": "glucose intolerance",
"pos": [
65,
84
]
} | {
"id": "C0020456",
"name": "hyperglycaemia",
"pos": [
89,
103
]
} |
atelectasis , alveolar consolidation ( due primarily to mononuclear inflammatory cells ) , and suppurative bronchitis and bronchiolitis were seen only in lew rats . | NA | {
"id": "C0006277",
"name": "bronchitis",
"pos": [
107,
117
]
} | {
"id": "C0006271",
"name": "bronchiolitis",
"pos": [
122,
135
]
} |
the fourth adenoma was an undifferentiated acidophilic adenoma showing pleomorphic cells having slight acidophil and partly mucoid granulations . | NA | {
"id": "C0001430",
"name": "adenoma",
"pos": [
11,
18
]
} | {
"id": "C0001433",
"name": "acidophilic adenoma",
"pos": [
43,
62
]
} |
to prove the association of the transfecting activity of nucleic acid from cells co-infected with tbe and sv40 viruses with dna , experiments were carried out using fractionation of nucleic acid preparations in cesium sulphate gradient an on a column with hap . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
57,
69
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
124,
127
]
} |
in the course of a health study carried out 1979 in vienna on more than 2,500 persons at the age of 25 , 40 and 60 years respectively , the following blood parameters were investigated : erythrocytes , hemoglobin , hematocrit , serum iron , ogtt , hba1 , uric acid , cholesterol , hdl-cholesterol , sgot , sgpt , ap , creatinine , bun ; | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
267,
278
]
} | {
"id": "C0023822",
"name": "hdl-cholesterol",
"pos": [
281,
296
]
} |
additional experiments with intracoronary injections of several electrolyte solutions indicate that the observed effects can be explained by contrast-induced changes in the extracellular electrolyte concentrations , mainly by a local deficiency of potassium ions and an excess of sodium ions . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
64,
75
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
287,
291
]
} |
plasma noradrenaline and adrenaline in pre-eclampsia , essential hypertension in pregnancy and normotensive pregnant control subjects . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
7,
20
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
25,
35
]
} |
noradrenaline and adrenaline in plasma were determined in 15 patients with pre-eclampsia , 10 pregnant patients with essential hypertension , 2 patients with transient hypertension in pregnancy , 11 normotensive pregnant control subjects , and 16 non-pregnant normotensive control subjects . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
0,
13
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
18,
28
]
} |
plasma noradrenaline and adrenaline in pregnancy were the same as in normotensive non-pregnant control subjects . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
7,
20
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
25,
35
]
} |
the concentration of progesterone , 20 alpha-dihydroprogesterone , testosterone , oestrone and oestradiol-17 beta in serum , amniotic fluid and placental tissue of pregnant rabbits . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
21,
33
]
} | {
"id": "C0012311",
"name": "20 alpha-dihydroprogesterone",
"pos": [
36,
64
]
} |
the concentrations of progesterone ( delta 4p ) , 20 alpha-dihydroprogesterone ( 20 alpha-dhp ) , testosterone ( t ) , oestrone ( e1 ) and oestradiol-17 beta ( e2 beta ) in peripheral blood serum ( pbs ) , amniotic fluid ( af ) and placental tissue of rabbits during gestation were determined by radioimmunoassay . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
22,
34
]
} | {
"id": "C0012311",
"name": "20 alpha-dihydroprogesterone",
"pos": [
50,
78
]
} |
although the amyloid fibril protein of the chronically diseased valves is still unknown , it may be neither protein aa nor al , and another type of amyloid is suggested . | NA | {
"id": "C1456454",
"name": "amyloid",
"pos": [
13,
20
]
} | {
"id": "C0002716",
"name": "amyloid",
"pos": [
148,
155
]
} |
imipramine elimination and metabolism was studied in a single-pass rat liver perfusion model with flow and pressure kept constant for a perfusion-period of 120-200 min . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
11,
22
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
27,
37
]
} |
the effect of glibenclamide and gliquidone on fasting blood glucose , 24-hour urinary glucose excretion , hba1 concentrations and on the blood glucose and plasma insulin responses to an oral glucose load were investigated in 11 patients with non-insulin-dependent diabetes mellitus . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
60,
67
]
} | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
137,
150
]
} |
in another experiment angiotensin ii was infused at 2 , 6 , 18 and 54 ng/kg/min into sodium-depleted dogs firstly without modification and secondly combined with captopril ( 6,000 micrograms/kg/hour ) given for 1 hour before the angiotensin dose-response study and continued throughout . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
22,
36
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
229,
240
]
} |
under some circumstances , especially where a qualitatively and quantitatively similar response occurs to angiotensin antagonists and angiotensin-converting enzyme inhibitors or where an angiotensin antagonist prevents an additional response to a converting enzyme inhibitor , it is clear that the specific action of the converting enzyme inhibitor on angiotensin ii formation is responsible . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
106,
117
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
352,
366
]
} |
while blood pressure decreased , the plasma-renin concentration increased to 700 percent of the initial value ( 6.1 +/- 2.5 ng angiotensin l/ml . h ) and angiotensin i increased to about 300 percent of the basal value ( 179 +/- 32 pg/ml ) . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
127,
138
]
} | {
"id": "C0003006",
"name": "angiotensin i",
"pos": [
154,
167
]
} |
three classes of lipoproteins were then separated by 4 % agarose-column chromatography : very low density lipoproteins ( vldl ) , low-density lipoproteins ( ldl ) , and high-density lipoproteins ( hdl ) . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
17,
29
]
} | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
89,
118
]
} |
heavy metals , including gold , mercury , lead , bismuth , and cadmium , have the potential to cause renal disease . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
0,
12
]
} | {
"id": "C0018026",
"name": "gold",
"pos": [
25,
29
]
} |
heavy metals , including gold , mercury , lead , bismuth , and cadmium , have the potential to cause renal disease . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
0,
12
]
} | {
"id": "C0025424",
"name": "mercury",
"pos": [
32,
39
]
} |
heavy metals , including gold , mercury , lead , bismuth , and cadmium , have the potential to cause renal disease . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
0,
12
]
} | {
"id": "C0023175",
"name": "lead",
"pos": [
42,
46
]
} |
heavy metals , including gold , mercury , lead , bismuth , and cadmium , have the potential to cause renal disease . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
0,
12
]
} | {
"id": "C0005642",
"name": "bismuth",
"pos": [
49,
56
]
} |
heavy metals , including gold , mercury , lead , bismuth , and cadmium , have the potential to cause renal disease . | NA | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
0,
12
]
} | {
"id": "C0006632",
"name": "cadmium",
"pos": [
63,
70
]
} |
although a self-limited myeloproliferative syndrome occurs in down 's syndrome , this case confirms that an identical disorder may develop in patients with mosaic trisomy 21 and no phenotypic stigmas of down 's syndrome . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
43,
51
]
} | {
"id": "C0012634",
"name": "disorder",
"pos": [
118,
126
]
} |
when immunoprecipitates that formed between ass and 125i-labeled lymphocyte surface glycoproteins were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis , it was found that ass precipitated a 72k molecular weight ( mw ) glycoprotein from t cells but not from b cells . | NA | {
"id": "C0025248",
"name": "surface glycoproteins",
"pos": [
76,
97
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
240,
252
]
} |
the seven glucose-tolerant transplant recipients had significantly increased insulin release during ivgtt compared to control subjects , and significant correlations were found among insulin release , glucose decay constant , and fasting blood sugar in those patients . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
10,
17
]
} | {
"id": "C0005802",
"name": "blood sugar in",
"pos": [
238,
252
]
} |
silver grains on this region constituted 25.5 % of all labeled sites , allowing assignment of the hpl and growth hormone ( hgh ) genes , which have over 90 % nucleotide homology in their coding sequences , to 17q22-24 . | NA | {
"id": "C0037663",
"name": "growth hormone",
"pos": [
106,
120
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
123,
126
]
} |
the highest levels were found in the vaginal delivery group ( norepinephrine and epinephrine , 3.9 +/- 2.1 and 1.1 +/- 1.0 nmoles/l , respectively ) , and the lowest in the epidural cesarean section group . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
62,
76
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
81,
92
]
} |
in spite of that , neonates delivered vaginally showed a markedly higher sympathoadrenal activation ( norepinephrine and epinephrine , 31.8 +/- 24.1 and 5.1 +/- 7.6 nmoles/l , respectively ) than those born by elective cesarean section . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
102,
116
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
121,
132
]
} |
in the latter group , however , it was found that the type of maternal anesthesia influenced fetal sympathoadrenal activation , since neonatal levels of catecholamines were higher in the epidural section group ( norepinephrine and epinephrine , 9.5 +/- 6.4 and 4.0 +/- 4.5 nmoles/l , respectively ) than in the general anesthesia group ( norepinephrine and epinephrine , 3.2 +/- 2.7 and 1.0 +/- 1.4 nmoles/l , respectively ) . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
212,
226
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
357,
368
]
} |
microscopic examination of the two excised lacrimal sacs showed that the walls were thickened by cells resembling fibroblasts and by cells resembling histiocytes . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
114,
125
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
133,
138
]
} |
the author explores the historical record and concludes that the hysterical ( histrionic ) personality is a caricature of femininity . | NA | {
"id": "C0020701",
"name": "hysterical",
"pos": [
65,
75
]
} | {
"id": "C0019681",
"name": "histrionic",
"pos": [
78,
88
]
} |
fractures associated with moderate trauma were responsible for the increased incidence with age and the excess among women . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
0,
9
]
} | {
"id": "C0043251",
"name": "trauma",
"pos": [
35,
41
]
} |
addition of soybean lecithin , or stearic acid , to fatty-acid-free , albumin-supplemented media yielded intermediate results , while similar addition of other nonesterified fatty acids proved non stimulatory . | NA | {
"id": "C0015684",
"name": "fatty-acid",
"pos": [
52,
62
]
} | {
"id": "C0015688",
"name": "nonesterified fatty acids",
"pos": [
160,
185
]
} |
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