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stringlengths 57
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values | h
dict | t
dict |
|---|---|---|---|
however , considerations of the differential repair capacities of nf and xp cells superimposed upon the kinetics of mt induction were invoked to explain the apparent differential uv sensitivity of mt induction . | NA | {
"id": "C0016030",
"name": "nf",
"pos": [
66,
68
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
76,
81
]
} |
liquid holding recovery experiments showed that nf cells possess the capacity to reactivate this inducible gene function rapidly while xp cells are deficient in the reactivation capacity . | NA | {
"id": "C0016030",
"name": "nf",
"pos": [
48,
50
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
138,
143
]
} |
by contrast , the rates of the phosphoryl exchange reactions catalyzed by enzyme i and the enzyme ii complexes were essentially the same for the associated and dissociated forms of the system . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
74,
80
]
} | {
"id": "C0026741",
"name": "enzyme",
"pos": [
91,
97
]
} |
epstein-barr viral capsid antigen and nuclear antigen produced by modified procedures were evaluated for use in measuring viral capsid antigen immunoglobulin m and epstein-barr virus nuclear antigen antibody responses in sera from patients with suspected epstein-barr virus infections . | NA | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
38,
53
]
} | {
"id": "C0116397",
"name": "epstein-barr virus nuclear antigen",
"pos": [
164,
198
]
} |
viral capsid antigen production was stimulated with a phorbol ester , and the epstein-barr virus nuclear antigen cells were fixed in suspension to eliminate loss of antigen during the drying process . | NA | {
"id": "C0003342",
"name": "viral",
"pos": [
0,
5
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
165,
172
]
} |
furthermore , brain heart infusion broth was found to have an inhibitory effect on detection of enterotoxin both in the gm1-elisa and in a toxin-binding modification of the y1 adrenal cell test , but not in the conventional adrenal cell assay . | NA | {
"id": "C0014372",
"name": "enterotoxin",
"pos": [
96,
107
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
139,
144
]
} |
the im heterophil antibodies were confirmed to be predominantly of the igm class , but moderate proportions of the igm class were sometimes encountered . | NA | {
"id": "C0020861",
"name": "igm",
"pos": [
71,
74
]
} | {
"id": "C0021017",
"name": "igm class",
"pos": [
115,
124
]
} |
in vitro evaluation of pyridine-2-azo-p-dimethylaniline cephalosporin , a new diagnostic chromogenic reagent , and comparison with nitrocefin , cephacetrile , and other beta-lactam compounds . | NA | {
"id": "C3536856",
"name": "cephalosporin",
"pos": [
56,
69
]
} | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
144,
156
]
} |
nitrocefin , however , demonstrated an unexpected and uniquely potent activity against streptococcus faecalis ( minimum inhibitory concentration , less than or equal to 0.06 to 0.12 microgram/ml ) the relative hydrolysis rate of padac when subjected to six different beta-lactamases was substantially greater than that of cephacetrile , but less than that of nitrocefin . | NA | {
"id": "C3536856",
"name": "padac",
"pos": [
229,
234
]
} | {
"id": "C0007714",
"name": "cephacetrile",
"pos": [
322,
334
]
} |
this greater hepatic triglyceride uptake by the perfused fasted liver in comparison to the fed was also noted for emulsions containing no added apoprotein or supplemented with both the e and ciii-1 proteins . | NA | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
144,
154
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
198,
206
]
} |
the universality of recognition of these antiidiotypic antisera indicate that the three-dimensional structure of a receptor 's binding site can be modeled by a subset of an elicited antibody population . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
55,
63
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
182,
190
]
} |
in the human , fibronectin , procollagen iv , and collagen v were observed along the internal aspect of gbm continuous with antigenic sites in the mesangium . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
29,
40
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
50,
58
]
} |
during a three-year period b ureolyticus was isolated from 103 fairly superficial necrotic or gangrenous lesions all of which showed evidence of active infection . | NA | {
"id": "C0027540",
"name": "necrotic",
"pos": [
82,
90
]
} | {
"id": "C0017086",
"name": "gangrenous",
"pos": [
94,
104
]
} |
the population was then randomized to receive either a lactose placebo , erythromycin base , erythromycin stearate , or erythromycin ethylsuccinate . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
73,
85
]
} | {
"id": "C0059566",
"name": "erythromycin stearate",
"pos": [
93,
114
]
} |
the population was then randomized to receive either a lactose placebo , erythromycin base , erythromycin stearate , or erythromycin ethylsuccinate . | NA | {
"id": "C0014806",
"name": "erythromycin",
"pos": [
73,
85
]
} | {
"id": "C0014810",
"name": "erythromycin ethylsuccinate",
"pos": [
120,
147
]
} |
treatment of fibroblasts with phorbol myristate acetate ( pma ; 10 ( -8 ) m ) induced the synthesis and secretion of large amounts of collagenase : this was inhibited if the cells were treated with retinoic acid ( 10 ( -6 ) m ) or dexamethasone ( 10 ( -7 m ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
13,
24
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
174,
179
]
} |
using vitamin a - deficient hamsters and rats , retinoic acid was shown to be as active as retinol in restoring the in vivo in corporation of mannose into glycoproteins to normal levels within a short time , in liver and tracheal tissues . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
6,
15
]
} | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
48,
61
]
} |
vitamin a ( retinol ) and its analogues ( retinoids ) are clinically effective in cystic acne and psoriasis , diseases in which neutrophils may constitute major components of inflammatory cell infiltrates . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
0,
9
]
} | {
"id": "C0035339",
"name": "retinoids",
"pos": [
42,
51
]
} |
since retinoids may exert anti-inflammatory effects by virtue of an action upon neutrophils , we studied the effects of the following retinoids on discrete neutrophil functions in vitro : retinol , retinyl acetate , retinal , tretinoin , isotretinoin , etretinate , and ro 10-1670 . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
6,
15
]
} | {
"id": "C0022265",
"name": "isotretinoin",
"pos": [
238,
250
]
} |
the clinical pharmacokinetic profiles of two orally administered retinoids , isotretinoin and etretinate , are discussed and compared . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
65,
74
]
} | {
"id": "C0022265",
"name": "isotretinoin",
"pos": [
77,
89
]
} |
this paper is a review of the acute , subchronic , and chronic toxicity , mutagenicity , carcinogenicity , and teratogenicity of vitamin a , tretinoin ( all-trans-retinoic acid ) , isotretinoin ( 13-cis-retinoic acid ) , and etretinate . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
129,
138
]
} | {
"id": "C0040845",
"name": "all-trans-retinoic acid",
"pos": [
153,
176
]
} |
administration of oral vitamin a and the synthetic retinoids to humans and experimental animals has been accompanied by changes in lipid metabolism . these changes include alterations in serum , liver , and skin surface lipids . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
23,
32
]
} | {
"id": "C0035339",
"name": "retinoids",
"pos": [
51,
60
]
} |
in rats , oral all-trans-retinoic acid , 13-cis-retinoic acid , and natural vitamin a have resulted in hypertriglyceridemia , while in man , 13-cis-retinoic acid , etretinate , and natural vitamin a have been reported to elicit this response . | NA | {
"id": "C0040845",
"name": "trans-retinoic",
"pos": [
19,
33
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
189,
198
]
} |
four retinoids - retinol ( vitamin a ) , tretinoin ( retinoic acid ) , etretinate ( the ethyl ester of trimethoxymethylphenyl retinoic acid ) , and isotretinoin ( 13-cis-retinoic acid , accutane ) - have been administered orally in humans for therapeutic purposes . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
5,
14
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
27,
36
]
} |
four retinoids - retinol ( vitamin a ) , tretinoin ( retinoic acid ) , etretinate ( the ethyl ester of trimethoxymethylphenyl retinoic acid ) , and isotretinoin ( 13-cis-retinoic acid , accutane ) - have been administered orally in humans for therapeutic purposes . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
5,
14
]
} | {
"id": "C0022265",
"name": "13-cis-retinoic acid",
"pos": [
163,
183
]
} |
four retinoids - retinol ( vitamin a ) , tretinoin ( retinoic acid ) , etretinate ( the ethyl ester of trimethoxymethylphenyl retinoic acid ) , and isotretinoin ( 13-cis-retinoic acid , accutane ) - have been administered orally in humans for therapeutic purposes . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
27,
36
]
} | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
170,
183
]
} |
the tumor-promoting phorbol ester , 12-o-tetradecanoylphorbol-13-acetate ( tpa ) causes a dose-dependent induction ( up to 300-fold ) of ornithine decarboxylase activity in the epidermis of intact mice within 5 hours after the application to the skin of from 1 to 10 nmoles of the ester in 0.2 ml of acetone . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
20,
33
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
36,
72
]
} |
treatment regimens in this group of syndromes are based on the notion that in these disorders there is a self-sustaining cycle of pain-spasm-pain persisting after the precipitating cause has disappeared , which may be permanently abolished by interruption of the reflex mechanisms . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
36,
45
]
} | {
"id": "C0012634",
"name": "disorders",
"pos": [
84,
93
]
} |
the cell source for the phenomena was the synovial cell of the joint , a highly versatile , facultative fibroblast . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
104,
114
]
} |
in this study , an in vitro model of immune complex-mediated basement membrane zone separation caused by periphigoid antibodies , serum complement , and peripheral blood leukocytes is described . | NA | {
"id": "C0003313",
"name": "immune complex",
"pos": [
37,
51
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
117,
127
]
} |
wax ester/sterol ester ( we/se ) ratios were measured in samples of vernix caseosa lipid obtained from 21 full-term infants . | NA | {
"id": "C0043076",
"name": "wax",
"pos": [
0,
3
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
83,
88
]
} |
wax esters ( a class of lipid produced only by the sebaceous glands ) were isolated from 6 of the 21 samples of vernix caseosa lipid and analyzed for fatty acid composition . | NA | {
"id": "C0043076",
"name": "wax",
"pos": [
0,
3
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
127,
132
]
} |
the percentages of iso and anteiso branched saturated fatty acids and of delta 9-type monounsaturated fatty acids were found to be correlated negatively with the we/se ratios of the original lipid samples . | NA | {
"id": "C0043076",
"name": "we/se",
"pos": [
162,
167
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
191,
196
]
} |
certain fractions reproducibly stimulated proliferation of allogeneic lymphocytes in the skin cell lymphocyte reaction , whereas other fractions , containing larger cells , supported growth of keratinocyte colonies in cell cultures . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
165,
170
]
} | {
"id": "C0022567",
"name": "colonies",
"pos": [
206,
214
]
} |
these results indicate that stimulation in the skin cell lymphocyte reaction and growth of keratinocyte colonies are mediated by distinct cells , separable by velocity sedimentation . | NA | {
"id": "C0022567",
"name": "colonies",
"pos": [
104,
112
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
138,
143
]
} |
it is proposed that an acute-phase complement reaction limits immune complex-mediated injury to tissue by maintaining those complement functions that are required for the effective processing of circulating antigen/antibody material . | NA | {
"id": "C0003313",
"name": "immune complex",
"pos": [
62,
76
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
215,
223
]
} |
the factors of coagulation ( xii , ix , viii , vii , x , xiii , prothrombin , platelet , fibrinogen ) , fibrinolytic enzyme system ( euglobulin clot lysis time , eug . lysis area of sk ( std ) , plasminogen , sfmc , fdp ) , serin protease inhibitor in plasma ( at-iii , c1-ina , alpha 2-pi , alpha 2-m , alpha 1-at ) and cig were determined on 30 normal non-pregnant women as control , and total 270 normal gravidas . | NA | {
"id": "C0005789",
"name": "factors",
"pos": [
4,
11
]
} | {
"id": "C0015491",
"name": "ix",
"pos": [
35,
37
]
} |
the factors of coagulation ( xii , ix , viii , vii , x , xiii , prothrombin , platelet , fibrinogen ) , fibrinolytic enzyme system ( euglobulin clot lysis time , eug . lysis area of sk ( std ) , plasminogen , sfmc , fdp ) , serin protease inhibitor in plasma ( at-iii , c1-ina , alpha 2-pi , alpha 2-m , alpha 1-at ) and cig were determined on 30 normal non-pregnant women as control , and total 270 normal gravidas . | NA | {
"id": "C0005789",
"name": "factors",
"pos": [
4,
11
]
} | {
"id": "C0033706",
"name": "prothrombin",
"pos": [
64,
75
]
} |
the inhibitory effect was found not to be antagonized by polyphloretin phosphate or di-4-phloretin phosphate . | NA | {
"id": "C0032574",
"name": "polyphloretin phosphate",
"pos": [
57,
80
]
} | {
"id": "C0031560",
"name": "phloretin",
"pos": [
89,
98
]
} |
this procedure of arthrography is very useful as a diagnostic tool in many occasions i.e . in making correct diagnosis in trauma of children such as fracture , dislocation and ligamentous injury ; | NA | {
"id": "C0043251",
"name": "trauma",
"pos": [
122,
128
]
} | {
"id": "C0016658",
"name": "fracture",
"pos": [
149,
157
]
} |
twenty consecutive patients with paroxysmal intra a-v nodal or atrio-ventricular tachycardia had a new tachycardia reversion pacing modality evaluated during routine electrophysiological study . | NA | {
"id": "C0042514",
"name": "ventricular",
"pos": [
69,
80
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
103,
114
]
} |
however , in older children with asd as compared to controls , a significant increase was noted for interval pa ( p less than 0.03 ) in children four to eight years old and for intervals hv ( p less than 0.01 ) and pr ( p less than 0.001 ) in children 9 to 16 years old . | NA | {
"id": "C1455726",
"name": "older children",
"pos": [
13,
27
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
243,
251
]
} |
rapidly repetitive responses and/or fibrillation were induced in the ischemic ventricle by two early premature beats in six of ten dogs , but these serious arrhythmias could be induced in none of the ten dogs after mexiletine pretreatment . | NA | {
"id": "C0340464",
"name": "premature beats",
"pos": [
101,
116
]
} | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
156,
167
]
} |
identification of both human and salmon calcitonin-like molecules in birds suggesting the existence of two calcitonin genes . | NA | {
"id": "C0073994",
"name": "salmon calcitonin",
"pos": [
33,
50
]
} | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
107,
117
]
} |
we found that extracts of thyroid and ubg from pigeons and chickens contain , in addition to an immunoreactive sct-like molecule ( which is the major immunoreactive form ) , an hct-like molecule comprising from 0.4 to 3.75 % of the calcitonin content . | NA | {
"id": "C0073994",
"name": "sct",
"pos": [
111,
114
]
} | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
232,
242
]
} |
the results indicate that in the guinea-pig , in spite of differences in proportions of adrenaline and noradrenaline in the adrenal gland and para-aortic body ( pab ) , the loss of labelled catecholamines from the innervated pab closely follows that from the adrenal medulla , suggesting that both participate in normal sympathoadrenal activity . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
88,
98
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
103,
116
]
} |
characterization of the lymphocyte membrane receptor for factor h ( beta 1h-globulin ) with an antibody to anti-factor h idiotype . | NA | {
"id": "C0005157",
"name": "beta",
"pos": [
68,
72
]
} | {
"id": "C0056207",
"name": "factor h",
"pos": [
112,
120
]
} |
because i-e appears to be the murine analogue of hla-d/dr , this finding is of interest with respect to the increased frequency of certain hla-dr alleles in sle patients , as discussed . | NA | {
"id": "C0019754",
"name": "hla-d",
"pos": [
49,
54
]
} | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
139,
145
]
} |
an optimized micromethod for the determination of soluble acetylcholinesterase and pseudocholinesterase in gastrointestinal biopsy tissue is introduced . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
58,
78
]
} | {
"id": "C0008429",
"name": "pseudocholinesterase",
"pos": [
83,
103
]
} |
small monovalent organic cations are able to permeate the channel : the channel conductance drops sharply for cations having molecular cross sections larger than 18-20 a2 . | NA | {
"id": "C0007449",
"name": "monovalent",
"pos": [
6,
16
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
110,
117
]
} |
the divalent cation mg2+ prevented the inactivating effected of tris at concentrations about 10 ( 3 ) -fold lower than monovalent cation k+ . | NA | {
"id": "C0007448",
"name": "divalent cation",
"pos": [
4,
19
]
} | {
"id": "C0007447",
"name": "cation",
"pos": [
130,
136
]
} |
the effect of sindbis virus on cell leakiness , as measured by chromium release , and on the fatty acids in chick embryo fibroblasts and vero cells was studied . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
31,
35
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
121,
132
]
} |
in seven dogs we compared the quality of blood-pool images obtained with tcdx of different molecular weights ( 4 x 10 ( 4 ) = dx-40 ; 5 x 10 ( 5 ) = dx-500 ; 2 x 10 ( 6 ) = dx-2000 ) and with tc-99m red blood cells ( tcrbc ) labeled in vitro , and determined the organ distribution of this new agent by whole-body scanning and blood sampling . | NA | {
"id": "C0011793",
"name": "dx-40",
"pos": [
126,
131
]
} | {
"id": "C0086140",
"name": "dx",
"pos": [
173,
175
]
} |
a control diet containing 10 % casein was diluted with either cellulose ( c ) , pectin ( p ) , lignin ( l ) , guar gum ( g ) , or wheat bran ( w ) at fiber levels ranging from 3 % to 20 % . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
62,
71
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
95,
101
]
} |
cellulose , pectin , lignin , sodium alginate and wheat bran were selected for their differing physical and chemical properties . | NA | {
"id": "C0007648",
"name": "cellulose",
"pos": [
0,
9
]
} | {
"id": "C0023705",
"name": "lignin",
"pos": [
21,
27
]
} |
a prospective study of renal osteodystrophy in moderate renal insufficiency was undertaken to assess the effects of 25 ( oh ) d3 ( calcifediol ) on healing of bone lesions and improvement of linear growth . | NA | {
"id": "C2713074",
"name": "25 ( oh ) d3",
"pos": [
116,
128
]
} | {
"id": "C0006657",
"name": "calcifediol",
"pos": [
131,
142
]
} |
the cemental surfaces of teeth with no clinical evidence of periodontal disease or teeth with gingivitis demonstrated no antibody . | NA | {
"id": "C0017563",
"name": "periodontal disease",
"pos": [
60,
79
]
} | {
"id": "C0017574",
"name": "gingivitis",
"pos": [
94,
104
]
} |
inhibition studies between serum antibody , extracted antigen and the antigen and antibody on the tooth surface suggest that we are dealing with the same antigen-antibody complex in all cases . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
33,
41
]
} | {
"id": "C0003313",
"name": "antigen-antibody complex",
"pos": [
154,
178
]
} |
a physiologically based pharmacokinetic model , which is an extension of the bischoff-dedrick multiorgan model , was developed to described the kinetics of barbiturates ( hexobarbital , phenobarbital , and thiopental ) in the rat . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
156,
168
]
} | {
"id": "C0019469",
"name": "hexobarbital",
"pos": [
171,
183
]
} |
injected 5'-guanylylimidodiphosphate , gpp ( nh ) p , mimics this action of gtp but the reversal seen with injected mg2+ is less pronounced . | NA | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
39,
51
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
76,
79
]
} |
( i ) pre-treatment of these fibres with verapamil reduces the size of the stimulatory response to gtp and gpp ( nh ) p . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
99,
102
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
107,
119
]
} |
gtp or gpp ( nh ) p when injected following peak stimulation by cholera toxin leads to a moderate sustained stimulation . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
0,
3
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
7,
19
]
} |
in view of the finding that cardiac carnitine acetyltransferase ( carat ) is able to acetylate choline ( white & wu , 1973 ) , the possible contribution of carat to the synthesis of ach in the muscles was investigated by using bromoacetylcholine ( brach ) as an inhibitor of chat and bromoacetylcarnitine ( bracar ) as an inhibitor of carat.2 . | NA | {
"id": "C0001068",
"name": "chat",
"pos": [
275,
279
]
} | {
"id": "C0007259",
"name": "carat",
"pos": [
335,
340
]
} |
the hypothesis is emitted that , like gallstones , the apparition of gas is a fissuration that may precede the spontaneous disappearance of the calculus . | NA | {
"id": "C0008350",
"name": "gallstones",
"pos": [
38,
48
]
} | {
"id": "C0006736",
"name": "calculus",
"pos": [
144,
152
]
} |
the staining was more pronounced with this antibody than with other monoclonal antibodies to the c gamma 2 domain of human igg produced following the same immunisation or immunisation with isolated igg . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
43,
51
]
} | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
68,
89
]
} |
culture of precompact zona-free mouse embryos in the plant lectin concanavalin a ( con a ) at 20 micrograms/ml inhibits blastocyst formation . | NA | {
"id": "C0304052",
"name": "plant lectin",
"pos": [
53,
65
]
} | {
"id": "C0009630",
"name": "concanavalin a",
"pos": [
66,
80
]
} |
finally , in a retrospective study of 26 patients with both thyroid disease and rheumatoid arthritis , 4 patients had a simultaneous onset of both myxoedema and rheumatoid arthritis , the activity of which was greatly improved by correction of the hypothyroid state . | NA | {
"id": "C0040128",
"name": "thyroid disease",
"pos": [
60,
75
]
} | {
"id": "C0020676",
"name": "hypothyroid",
"pos": [
248,
259
]
} |
there is a high incidence of sciatica and of damage to the pelvic floor musculature , but although the pain has features consistent with a neuralgia , its cause is unknown . | NA | {
"id": "C0036396",
"name": "sciatica",
"pos": [
29,
37
]
} | {
"id": "C0027796",
"name": "neuralgia",
"pos": [
139,
148
]
} |
there is a high incidence of sciatica and of damage to the pelvic floor musculature , but although the pain has features consistent with a neuralgia , its cause is unknown . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
103,
107
]
} | {
"id": "C0027796",
"name": "neuralgia",
"pos": [
139,
148
]
} |
a series of mercaptoacyl amino acids and related compounds was synthesized and evaluated for inhibition of angiotensin-converting enzyme ( ace ) in order to determine the nature and importance of the putative interaction between ace and the amide moiety of inhibitors such as captopril ( 3-mercapto-2-methylpropanoyl-l-proline ) . | NA | {
"id": "C0006938",
"name": "captopril",
"pos": [
276,
285
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
319,
326
]
} |
a comparison of these hypoglycemic agents with classical standards ( tolazamide , phenformin , and buformin ) in several experimental models showed that the benzamidines seem to combine in one molecule some of the biological activities of the beta-cytotrophic sulfonylureas and some of the activities of the biguanides . | NA | {
"id": "C0040372",
"name": "tolazamide",
"pos": [
69,
79
]
} | {
"id": "C0038766",
"name": "sulfonylureas",
"pos": [
260,
273
]
} |
a comparison of these hypoglycemic agents with classical standards ( tolazamide , phenformin , and buformin ) in several experimental models showed that the benzamidines seem to combine in one molecule some of the biological activities of the beta-cytotrophic sulfonylureas and some of the activities of the biguanides . | NA | {
"id": "C0031404",
"name": "phenformin",
"pos": [
82,
92
]
} | {
"id": "C0005382",
"name": "biguanides",
"pos": [
308,
318
]
} |
a comparison of these hypoglycemic agents with classical standards ( tolazamide , phenformin , and buformin ) in several experimental models showed that the benzamidines seem to combine in one molecule some of the biological activities of the beta-cytotrophic sulfonylureas and some of the activities of the biguanides . | NA | {
"id": "C0006359",
"name": "buformin",
"pos": [
99,
107
]
} | {
"id": "C0005382",
"name": "biguanides",
"pos": [
308,
318
]
} |
synthesis and dopaminergic properties of some exo- and endo-2-aminobenzonorbornenes designed as rigid analogue of dopamine . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
14,
26
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
114,
122
]
} |
use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
114,
121
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
131,
137
]
} |
n6- ( omega-aminoalkyl ) derivatives of adenosine 5'-monophosphate ( amp ) were converted into their omega-n-carbobenzyloxy derivatives , and these were converted , via the 2',3'-o-carbonyl derivatives of their 5'-phosphorimidazolidates , into the corresponding atp derivatives . | NA | {
"id": "C0001413",
"name": "adenosine",
"pos": [
40,
49
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
262,
265
]
} |
condensation of n6- ( omega-aminoalkyl ) derivatives of amp with n-hydroxysuccinimide esters of omega- [ n- ( carbobenzyloxy ) amino ] carboxylic acids gave n6- ( ch2 ) nnhco ( ch2 ) mnh-cbz derivatives of amp which , upon conversion to the corresponding derivatives of atp , followed by removal of the carbobenzyloxy group and iodoacetylation , as described above , gave n6- ( ch2 ) nnhco ( ch2 ) mnhcoch2i-atp derivatives ( n = 3 , m = 5 or 6 ; n = 4 , m = 5 ; n = 6 , m = 1 -- 6 ) . | NA | {
"id": "C0014898",
"name": "esters",
"pos": [
86,
92
]
} | {
"id": "C0007066",
"name": "carboxylic acids",
"pos": [
135,
151
]
} |
condensation of n6- ( omega-aminoalkyl ) derivatives of amp with n-hydroxysuccinimide esters of omega- [ n- ( carbobenzyloxy ) amino ] carboxylic acids gave n6- ( ch2 ) nnhco ( ch2 ) mnh-cbz derivatives of amp which , upon conversion to the corresponding derivatives of atp , followed by removal of the carbobenzyloxy group and iodoacetylation , as described above , gave n6- ( ch2 ) nnhco ( ch2 ) mnhcoch2i-atp derivatives ( n = 3 , m = 5 or 6 ; n = 4 , m = 5 ; n = 6 , m = 1 -- 6 ) . | NA | {
"id": "C0001413",
"name": "amp",
"pos": [
56,
59
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
408,
411
]
} |
the same sequence of reactions starting with n6- [ omega- ( methylamino ) alkyl ] derivatives of n6-ch3-amp gave n6-ch3 , n6- ( ch2 ) nh ( ch3 ) co ( ch2 ) mnhcoch2i derivatives of atp ( n = 4 , m = 3 , 5 or 6 ; n = 6 , m = 5 or 6 ) . | NA | {
"id": "C0001413",
"name": "amp",
"pos": [
104,
107
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
181,
184
]
} |
use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
114,
121
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
131,
137
]
} |
the inhibition appeared not to be atp site directed because kinetic analysis indicated a random bimolecular enzyme-inhibitor reaction and because n6- ( ch2 ) 8nhcoch2i-amp and its adenosine counterpart , which have relatively low affinity for the atp site , were more effective than n6- ( ch2 ) 8nhcoch2i-atp . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
180,
189
]
} | {
"id": "C0001480",
"name": "atp",
"pos": [
305,
308
]
} |
use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators . | NA | {
"id": "C0022173",
"name": "isozyme",
"pos": [
114,
121
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
131,
137
]
} |
the study of complement in normal pregnancy showed a decrease in c1-inh , c1s and c1q , whereas c3 , c5 , c9 and the properdin factor b increased during the following weeks of gestation ; | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
13,
23
]
} | {
"id": "C0033453",
"name": "properdin factor b",
"pos": [
117,
135
]
} |
growth and cell survival following treatment with estramustine nor-nitrogen mustard , estradiol and testosterone of a human prostatic cancer cell line ( du 145 ) . | NA | {
"id": "C0014921",
"name": "estramustine",
"pos": [
50,
62
]
} | {
"id": "C0014912",
"name": "estradiol",
"pos": [
86,
95
]
} |
immune complexes composed of antibody and hsv antigen are present in serum samples of patients with em after hsv infection and some cases of em of uncertain cause and may mediate the pathogenesis of these disorders . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
0,
16
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
29,
37
]
} |
one patient each with colitis , tonsillitis and facial cellulitis , pharyngitis showed excellent response and 1 patient each with purulent thyroiditis and gluteal abscess showed good response . | NA | {
"id": "C0040425",
"name": "tonsillitis",
"pos": [
32,
43
]
} | {
"id": "C0031350",
"name": "pharyngitis",
"pos": [
68,
79
]
} |
from 1965 to 1980 , reoperations for residual or recurrent stones were performed on 78 out of 962 japanese patients with cholelithiasis . | NA | {
"id": "C0006736",
"name": "stones",
"pos": [
59,
65
]
} | {
"id": "C0008350",
"name": "cholelithiasis",
"pos": [
121,
135
]
} |
peripheral blood mononuclear cells ( pbmc ) , t-cells , non-t-cells , tg cells , and tm cells were tested for leukocyte adherence inhibition ( lai ) reactivity to purified protein derivative ( ppd ) in normal human volunteers to determine the reactive cell subfractions . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
0,
34
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
252,
256
]
} |
fresh pbmc , t-cells , and tg cells gave positive lai reactivity to ppd in ppd-positive donors only . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
6,
10
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
30,
35
]
} |
pbmc that had undergone 24-hour incubation or extensive washing , non-t-cells , and tm cells were unreactive . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
0,
4
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
87,
92
]
} |
indirect lai assay was performed on the spent media from overnight incubation of unstimulated pbmc and also following a 1-hour incubation of the various cell subfractions obtained from a ppd-reactive donor with ppd . | NA | {
"id": "C1321301",
"name": "pbmc",
"pos": [
94,
98
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
153,
157
]
} |
morphologically altered cells appeared in the cultures of carcinogen-treated ac fibroblasts at passages 6-8 ( days 100-140 ) after treatment with the carcinogens , but carcinogen-treated normal cells and untreated ac and normal cells did not become altered even after cultivation for 25 passages . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
80,
91
]
} | {
"id": "C0007634",
"name": "normal cells",
"pos": [
221,
233
]
} |
in 16 patients who also had other extra-adrenal paragangliomas , suggesting a multiple primary tumor syndrome , cbt were diagnosed significantly earlier ( mean , 35.4 yr ; p less than 0.01 ) . | NA | {
"id": "C0030422",
"name": "extra-adrenal",
"pos": [
34,
47
]
} | {
"id": "C0007279",
"name": "cbt",
"pos": [
112,
115
]
} |
in each animal absorption of one carcinogen and inulin was studied in one control loop and in an experimental loop containing either deoxycholic acid ( doc ) or chenodeoxycholic acid ( cdoc ) . | NA | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
133,
149
]
} | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
161,
182
]
} |
deuterium-labeled nitrosomethylethylamine , in which deuterium replaces hydrogen on the beta-carbon atom of nitrosomethylethylamine , induced a high incidence of esophageal tumors as well as liver tumors after administration of identical doses . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
0,
9
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
72,
80
]
} |
in subsample of patients with multiple myeloma , the paraprotein types as well as the k : lambda ratio resembled the frequency distribution of normal immunoglobulins . | NA | {
"id": "C0030490",
"name": "paraprotein",
"pos": [
53,
64
]
} | {
"id": "C0021027",
"name": "immunoglobulins",
"pos": [
150,
165
]
} |
in astrocytomas odc levels increased linearly and progressively from infratentorial pilocytic astrocytoma ( grade i ) to glioblastoma multiforme ( grade iv ) and corrected well with the degree of histologic malignancy of the tumor . | NA | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
3,
15
]
} | {
"id": "C0017636",
"name": "glioblastoma multiforme",
"pos": [
121,
144
]
} |
in tumors of neuroepithelial tissue odc level increases and , when present , amd level increases were not due to proliferation of new blood vessels , because cns hemangioblastomas had very low levels of both pbd activities . | NA | {
"id": "C0029282",
"name": "odc",
"pos": [
36,
39
]
} | {
"id": "C0007054",
"name": "pbd",
"pos": [
208,
211
]
} |
in tumors of neuroepithelial tissue odc level increases and , when present , amd level increases were not due to proliferation of new blood vessels , because cns hemangioblastomas had very low levels of both pbd activities . | NA | {
"id": "C0036003",
"name": "amd",
"pos": [
77,
80
]
} | {
"id": "C0007054",
"name": "pbd",
"pos": [
208,
211
]
} |
however , atypical forms of meningioma , i.e. , those with mitotic figures , whatever the histologic variants , had higher levels of odc , but not of amd , than the typical forms , i.e. , those without mitotic figures . | NA | {
"id": "C0007054",
"name": "odc",
"pos": [
133,
136
]
} | {
"id": "C0036003",
"name": "amd",
"pos": [
150,
153
]
} |
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