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stringlengths 57
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stringclasses 125
values | h
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dict |
|---|---|---|---|
the significance of the presence of these types of chromosomal aberrations in the blood of alcoholics is discussed in terms of its prevalence and association with known syndromes and diseases . | NA | {
"id": "C0039082",
"name": "syndromes",
"pos": [
169,
178
]
} | {
"id": "C0012634",
"name": "diseases",
"pos": [
183,
191
]
} |
a convenient continuous-rate spectrophotometric method for determination of amino acid substrate specificity of aminotransferases : application to isoenzymes of aspartate aminotransferase . | NA | {
"id": "C0002594",
"name": "aminotransferases",
"pos": [
112,
129
]
} | {
"id": "C0004002",
"name": "aspartate aminotransferase",
"pos": [
161,
187
]
} |
glycoconjugate in these sites stained for sulfate esters with the high iron diamine method but lacked reactivity toward the periodic acid-thiocarbohydrazide-silver proteinate ( pa-t-sp ) sequence for visualizing vic glycol-containing glycoprotein . | NA | {
"id": "C0017906",
"name": "glycoconjugate",
"pos": [
0,
14
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
234,
246
]
} |
the cellular organization of fibroblastic cells and macrophages at regions of uncalcified cartilage resorption in the embryonic chick femur as revealed by alkaline and acid phosphatase histochemistry . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "cellular",
"pos": [
4,
12
]
} |
the relative localizations and the presence of cellular interactions of these two cell types suggests that protein synthetic cells may be of fibroblastic origin , and may play a primary role in cartilage degradation , while macrophages , in keeping with biochemical evidence , play an adjunct or possibly a regulative role . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
47,
55
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
141,
153
]
} |
hemagglutination titer was decreased by proteolytic enzyme treatments , but was not affected by glycosidase , lipase , phospholipase , and neuraminidase treatments . | NA | {
"id": "C0017976",
"name": "glycosidase",
"pos": [
96,
107
]
} | {
"id": "C0027803",
"name": "neuraminidase",
"pos": [
139,
152
]
} |
antibody , immune complexes , and complement activity fluctuations in kittens with experimentally induced feline infectious peritonitis . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
0,
8
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
11,
27
]
} |
the influence of bacterial lipopolysaccharides on plasma zn and fe concentrations and the endotoxin-neutralizing capacity of polymyxin b was studied in 3 dairy cows . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
27,
46
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
90,
99
]
} |
although total daily urinary electrolyte excretion decreased during these periods , urinary electrolyte concentrations of the major ions often remained unchanged , or in the case of sodium , actually increased . | NA | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
29,
40
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
132,
136
]
} |
there was a highly significant correlation between the urinary excretion of the principal cations , sodium and potassium , and the principal anion , chloride . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
141,
146
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
149,
157
]
} |
five causes of operative or postoperative stroke were identified : 1 ) operative embolization , 2 ) postoperative hypertensive episodes with cerebral hemorrhage , 3 ) technical error , 4 ) conversion of ischemic infarct to hemorrhagic infarct , and 5 ) clamp-time ischemia . | NA | {
"id": "C0021308",
"name": "infarct",
"pos": [
212,
219
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
264,
272
]
} |
clinical effects produced by iflra and ifn-c were similar , including fever , chills , myalgias , headache fatigue , and reversible leukopenia and granulocytopenia . | NA | {
"id": "C0023530",
"name": "leukopenia",
"pos": [
132,
142
]
} | {
"id": "C0001824",
"name": "granulocytopenia",
"pos": [
147,
163
]
} |
due to the linkage of omp-synthesizing polysomes to the cell envelope , the whole machinery involved in the synthesis of omp must necessarily be membrane-bound and dynamic . | NA | {
"id": "C0033684",
"name": "omp",
"pos": [
22,
25
]
} | {
"id": "C0034861",
"name": "synthesis",
"pos": [
108,
117
]
} |
in contrast , the residues of lysine , alanine and aspartic acid ( or asparagine ) account for about a third of the approximately 360 amino acid residues in the protein . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
39,
46
]
} | {
"id": "C0002520",
"name": "amino",
"pos": [
134,
139
]
} |
ascorbic acid and dehydroascorbic acid were estimated in the blood of normal healthy subjects and diabetic patients . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
0,
13
]
} | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
18,
38
]
} |
the ascorbic acid level was low in the blood of diabetic patients but the dehydroascorbic acid content was remarkably high , irrespective of age , sex , history of diabetes , or treatment . | NA | {
"id": "C0003968",
"name": "ascorbic",
"pos": [
4,
12
]
} | {
"id": "C0011177",
"name": "dehydroascorbic",
"pos": [
74,
89
]
} |
up to 30 % of children with lead concentrations of greater than or equal to 40 g/100 ml ( greater than or equal to 1.93 mumol/l ) and nearly 60 % of children with greater than or equal to 30 microgram/100 ml ( greater than or equal to 1.45 mumol/l ) would remain undetected if protoporphyrin analysis were used for screening with an action level of 60 microgram/100 ml ( 1.07 mumol/l ) for the porphyrin analysis . | NA | {
"id": "C0033733",
"name": "protoporphyrin",
"pos": [
277,
291
]
} | {
"id": "C0032712",
"name": "porphyrin",
"pos": [
394,
403
]
} |
the predictive power of protoporphyrin analyses improves with the age of the child , indicating that the less expensive protoporphyrin test may be acceptable for older children , if by this means a large population of children at risk can be screened . | NA | {
"id": "C1455726",
"name": "older children",
"pos": [
162,
176
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
218,
226
]
} |
the serum concentration of lipoprotein lp ( a ) and of other lipoproteins of 64 individuals consuming more than 200 g of ethanol per day for several years was measured . | NA | {
"id": "C0065058",
"name": "lipoprotein lp ( a",
"pos": [
27,
45
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
61,
73
]
} |
22 alcohol drinkers with alc exhibited strikingly reduced values of all serum lipids and lipoproteins and the lowest lp ( a ) concentrations of all . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
89,
101
]
} | {
"id": "C0065058",
"name": "lp ( a",
"pos": [
117,
123
]
} |
it was found that there was an increase in metabolic rate after all sugars , greatest after sucrose and least with glucose and with fructose . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
68,
74
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
92,
99
]
} |
to study the relationship between fiber size and vulnerability to ischemia , we produced partial infarction of the proximal posterior tibial nerve of wistar rats by injecting arachidonic acid into the ipsilateral femoral artery . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
66,
74
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
97,
107
]
} |
despite limitations in our present knowledge it is already possible to discern the main features of peptide hormone evolution , since the same mechanisms ( and indeed the same hormone molecules ) function in many different ways . | NA | {
"id": "C0597192",
"name": "peptide hormone",
"pos": [
100,
115
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
176,
183
]
} |
the most surprising recent findings in endocrinology have been the discovery of vertebrate peptide hormones in multiple sites within the same organism , and the reports , persuasive but requiring confirmation , of vertebrate hormones in primitive unicellular organisms ( 20 , 20a ) . | NA | {
"id": "C0597192",
"name": "peptide hormones",
"pos": [
91,
107
]
} | {
"id": "C0019932",
"name": "hormones",
"pos": [
225,
233
]
} |
the antibacterial activity and pharmacokinetics of the beta-lactamase-stable cephalosporin cefuroxime and the gram-negative beta-lactamase-susceptible cephalosporin cefazolin were compared in two contrasting infection models in which proteus morganii 82 , which produces chromosomally mediated beta-lactamase , was the pathogen . | NA | {
"id": "C0728805",
"name": "beta-lactamase",
"pos": [
55,
69
]
} | {
"id": "C0597979",
"name": "beta-lactamase",
"pos": [
294,
308
]
} |
the antipseudomonal activities of cefotaxime , ceftizoxime , ceftazidime , ceftriaxone , cefoperazone , and moxalactam were tested in conventional minimum inhibitory concentration titrations and according to morphological and turbidimetric criteria . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
34,
44
]
} | {
"id": "C0007560",
"name": "ceftizoxime",
"pos": [
47,
58
]
} |
the antipseudomonal activities of cefotaxime , ceftizoxime , ceftazidime , ceftriaxone , cefoperazone , and moxalactam were tested in conventional minimum inhibitory concentration titrations and according to morphological and turbidimetric criteria . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
34,
44
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
75,
86
]
} |
judged in this way , moxalactam was the most active compound in relation to its minimum inhibitory concentration , but in comparative experiments in which the same concentration of each drug ( 64 microgram/ml ) was used regardless of the minimum inhibitory concentration , ceftazidime appeared to be the most active antibiotic , followed by ceftriaxone and cefotaxime . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
341,
352
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
357,
367
]
} |
clindamycin uptake was not influenced by the presence of hexose or amino acids , but was inhibited by nucleosides ( adenosine , puromycin ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
116,
125
]
} | {
"id": "C0034145",
"name": "puromycin",
"pos": [
128,
137
]
} |
under certain conditions , sulfamethoxazole enhanced trimethoprim bactericidal activity against e. coli k-12 carrying plasmid r1 at concentrations of sulfamethoxazole far below those required to inhibit the organism , but there was no such enhancement with the same host containing the ssu plasmid . | NA | {
"id": "C0041044",
"name": "sulfamethoxazole",
"pos": [
27,
43
]
} | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
150,
166
]
} |
previous results indicating that cefadroxil has greater persistence than other oral cephalosporins such as cephalexin , cephradine , cefaclor were confirmed . | NA | {
"id": "C0007538",
"name": "cefadroxil",
"pos": [
33,
43
]
} | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
107,
117
]
} |
previous results indicating that cefadroxil has greater persistence than other oral cephalosporins such as cephalexin , cephradine , cefaclor were confirmed . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
107,
117
]
} | {
"id": "C0007738",
"name": "cephradine",
"pos": [
120,
130
]
} |
previous results indicating that cefadroxil has greater persistence than other oral cephalosporins such as cephalexin , cephradine , cefaclor were confirmed . | NA | {
"id": "C0007716",
"name": "cephalexin",
"pos": [
107,
117
]
} | {
"id": "C0007537",
"name": "cefaclor",
"pos": [
133,
141
]
} |
the minimal inhibitory and bactericidal concentrations for 108 group b streptococcal strains were determined for two new cephalosporins , cefonicid and ceftizoxime , and compared to those of penicillin g . | NA | {
"id": "C3536856",
"name": "cephalosporins",
"pos": [
121,
135
]
} | {
"id": "C0007551",
"name": "cefonicid",
"pos": [
138,
147
]
} |
growth and extended periods of survival occurred in sterile sediments , sterile waters , and nonsterile waters , but not in nonsterile sediments . | NA | {
"id": "C0359299",
"name": "sterile waters",
"pos": [
72,
86
]
} | {
"id": "C0043047",
"name": "waters",
"pos": [
104,
110
]
} |
hormones -- such as serum oestradiol , oestrone , delta 4-androstenedione , progesterone , dehydroepiandrosterone ( dhea ) , follicle-stimulating hormone , luteinising hormone , and prolactin , and urinary 17-ketosteroids -- were measured . | NA | {
"id": "C0014942",
"name": "oestrone",
"pos": [
39,
47
]
} | {
"id": "C0000167",
"name": "17-ketosteroids",
"pos": [
206,
221
]
} |
hormones -- such as serum oestradiol , oestrone , delta 4-androstenedione , progesterone , dehydroepiandrosterone ( dhea ) , follicle-stimulating hormone , luteinising hormone , and prolactin , and urinary 17-ketosteroids -- were measured . | NA | {
"id": "C0002860",
"name": "delta 4-androstenedione",
"pos": [
50,
73
]
} | {
"id": "C0000167",
"name": "17-ketosteroids",
"pos": [
206,
221
]
} |
by means of rna isolation , polyacrylamide gel electrophoresis , and rna quantitation , it was demonstrated that captan caused a selective loss of large ( 16 and 23 s ) ribosomal rna 's . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
12,
15
]
} | {
"id": "C0035701",
"name": "ribosomal rna 's",
"pos": [
169,
185
]
} |
it was determined , in vitro , that 10 ( -3 ) m carbaryl would inhibit human serum ( pseudocholinesterase ) and erythrocyte acetylcholinesterase for at least 72 hr . | NA | {
"id": "C0008429",
"name": "pseudocholinesterase",
"pos": [
85,
105
]
} | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
124,
144
]
} |
the analysis revealed changes in the precipitation morphology in the majority of circulating proteins extending from the albumin to the gamma-region . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
93,
101
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
121,
128
]
} |
effect of sulprostone on concentrations of progesterone , 20 alpha-dihydroprogesterone , estrone , and estradiol in human placental tissue in the first trimester of pregnancy . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
43,
55
]
} | {
"id": "C0012311",
"name": "20",
"pos": [
58,
60
]
} |
placentas were obtained from 35 healthy women whose pregnancy was terminated in the first trimester . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
52,
61
]
} | {
"id": "C0032979",
"name": "first trimester",
"pos": [
84,
99
]
} |
concentrations of progesterone and 20 alpha-dihydroprogesterone were determined from the extract of the placenta by liquid chromatography and those of estrone and estradiol by a radioimmunoassay . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
18,
30
]
} | {
"id": "C0012311",
"name": "20 alpha-dihydroprogesterone",
"pos": [
35,
63
]
} |
placental progesterone concentration ( 6,829 +/- 469 ng/g wet weight , mean +/- sem ) was higher in the sulprostone group than in the control group ( 5,070 +/- 539 ng/g , p less than 0.02 ) , but the mean concentrations of 20 alpha-dihydroprogesterone , estrone and estradiol were similar in both groups . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
10,
22
]
} | {
"id": "C0012311",
"name": "20",
"pos": [
223,
225
]
} |
con-a binding correlated well with blood viscosity , c-reactive protein , and other individual acute phase reactants in patients with active ra . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
53,
71
]
} | {
"id": "C0001347",
"name": "acute phase",
"pos": [
95,
106
]
} |
a statistical difference was found in the incidence of fever after the third postoperative day between patients without infection and patients with bacteremia , wound infection , or pneumonia . | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
120,
129
]
} | {
"id": "C0043241",
"name": "wound infection",
"pos": [
161,
176
]
} |
the specificity of binding was shown by the lack of competence in the binding process of some other glycosaminoglycans used at concentrations 20 x higher than heparin . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
100,
118
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
159,
166
]
} |
chronic administration of clonidine to six month old spontaneously hypertensive rats ( shr ) by continuous infusion with alzet minipumps resulted in a decreased systolic arterial pressure , a decrease in heart weight , protein content and the incorporation of precursors of cellular protein and glycoprotein into the myocardium . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
219,
226
]
} | {
"id": "C0033665",
"name": "precursors",
"pos": [
260,
270
]
} |
ten-fold lower values were found with digitoxigenin bisdigitoxoside and only traces of glucuronides were formed with digitoxin , digitoxigenin or its 3-epimer . | NA | {
"id": "C0012258",
"name": "digitoxin",
"pos": [
117,
126
]
} | {
"id": "C0012257",
"name": "digitoxigenin",
"pos": [
129,
142
]
} |
seven such cases are reported : 2 patients with cardiogenic shock due to left ventricle myocardial infarction ; | NA | {
"id": "C0036980",
"name": "cardiogenic shock",
"pos": [
48,
65
]
} | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
88,
109
]
} |
an unusual disorder of liver development , which is to our knowledge not described in the literature , was observed in a female infant who died , at the age of 25 weeks , of the sequelae of portal hypertension . | NA | {
"id": "C0023895",
"name": "disorder of liver",
"pos": [
11,
28
]
} | {
"id": "C0020541",
"name": "portal hypertension",
"pos": [
190,
209
]
} |
pain around the hip joint and femoral neuropathy in a patient with a bleeding coagulopathy should alert the physician to the possibility of an iliopsoas haematoma . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
69,
77
]
} | {
"id": "C0018944",
"name": "haematoma",
"pos": [
153,
162
]
} |
cystic epithelioma ( 54 observations ) is a slowly growing tumor represented by outgrowths in the cyst lumen of differentiated squamous epithelium apt to form smaller cysts . | NA | {
"id": "C0027651",
"name": "tumor",
"pos": [
59,
64
]
} | {
"id": "C0010709",
"name": "cysts",
"pos": [
167,
172
]
} |
inflammatory changes in the mucous membrane were characterized by diffuse-focal lymphoplasma cell infiltrates , desquamation of transitional epithelium of the bladder and urethra , parapedesis of lymphocytes and polymorphonuclear leukocytes into the urethra lumen , activation of the fibroblast synthesis with excessive formation of collagen , proliferation of tegmental epithelium of the urethra with formation of deep pockets . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
93,
97
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
284,
294
]
} |
considering the cell composition and the level of the tumor tissue differentiation , the so-called goblet-cell carcinoid should be regarded as a peculiar invasive mucous adenoma but not as a variety of carcinoid ( apudoma ) . | NA | {
"id": "C0001430",
"name": "adenoma",
"pos": [
170,
177
]
} | {
"id": "C0003650",
"name": "apudoma",
"pos": [
214,
221
]
} |
the activity of enzymes releasing glucose and reducing sugars from sucrose , maltose , starch and dextran was compared in the same pooled samples of plaque fluid ( pf ) from 24 h human dental plaque . | NA | {
"id": "C0242209",
"name": "sugars",
"pos": [
55,
61
]
} | {
"id": "C0038636",
"name": "sucrose",
"pos": [
67,
74
]
} |
after administration of intravenous ( iv ) fluorescein sodium , diabetes , hypertension , or sodium iodate treatment resulted in an increased vitreous accumulation of iv fluorescein . | NA | {
"id": "C0147866",
"name": "fluorescein sodium",
"pos": [
43,
61
]
} | {
"id": "C0060520",
"name": "fluorescein",
"pos": [
170,
181
]
} |
catecholamines ( i.e. , epinephrine , norepinephrine , isoproterenol ) , which normally induce relaxation on these isolated coronary arteries , always induced contraction after use of dl-propranolol . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
0,
14
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
55,
68
]
} |
catecholamines ( i.e. , epinephrine , norepinephrine , isoproterenol ) , which normally induce relaxation on these isolated coronary arteries , always induced contraction after use of dl-propranolol . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
24,
35
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
38,
52
]
} |
intracellular phosphate and its possible role as an exchange anion for active transport of methotrexate in l1210 cells . | NA | {
"id": "C0031603",
"name": "phosphate",
"pos": [
14,
23
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
61,
66
]
} |
enzymatic reduction of synthetic hemin to heme and its application to study on oxygenation in aqueous medium . | NA | {
"id": "C0018988",
"name": "hemin",
"pos": [
33,
38
]
} | {
"id": "C0018966",
"name": "heme",
"pos": [
42,
46
]
} |
qb proved to be a noncompetitive inhibitor of both acetylcholinesterase ( or true cholinesterase ) and butyrylcholinesterase ( or pseudocholinesterase ) having a ki = 0.5 x 10 ( -6 ) m for acetylcholinesterase and 1.5 x 10 ( -6 ) m for butyrylcholinesterase . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
51,
71
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
236,
257
]
} |
recently , we found interferon in the sera of patients with systemic lupus erythematosus , rheumatoid arthritis , scleroderma , and sjogren 's syndrome . | NA | {
"id": "C0003873",
"name": "rheumatoid arthritis",
"pos": [
91,
111
]
} | {
"id": "C1527336",
"name": "sjogren 's syndrome",
"pos": [
132,
151
]
} |
of interest are the questions raised about the origin of ifn in the sera of patients with sle and what role ifn might have in the pathogenesis of the autoimmune disease in view of the many documented immunomodulating effects of ifn . | NA | {
"id": "C0024141",
"name": "sle",
"pos": [
90,
93
]
} | {
"id": "C0004364",
"name": "autoimmune disease",
"pos": [
150,
168
]
} |
several investigators have observed increased levels of esterified oleic acid in tissue cholesterol esters and phospholipids of atherosclerotic humans and cholesterol-fed animals . | NA | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
88,
106
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
155,
166
]
} |
bleeding and acute anemia after surgical drainage of a prepucial hematoma and a joint hematoma of the left knee after synovectomy and application of a prosthesis . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
0,
8
]
} | {
"id": "C0018944",
"name": "hematoma",
"pos": [
86,
94
]
} |
the establishment in culture and characterization of 4 human neuroblastoma ( nb ) cell lines and 1 human ganglioneuroblastoma cell line are described . | NA | {
"id": "C0027819",
"name": "neuroblastoma",
"pos": [
61,
74
]
} | {
"id": "C0206718",
"name": "ganglioneuroblastoma",
"pos": [
105,
125
]
} |
liver biopsy and serum specimens obtained from patients with cholesterol gallstones and from a control group were analysed for their different lipids and lipoprotein fractions . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
143,
149
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
154,
165
]
} |
in pss the beta-galactosidase activity was significantly increased compared with controls and the other connective tissue diseases . | NA | {
"id": "C0036421",
"name": "pss",
"pos": [
3,
6
]
} | {
"id": "C0009782",
"name": "connective tissue diseases",
"pos": [
104,
130
]
} |
these changes of enzyme pattern seem to be a relatively reliable marker for the differential diagnosis of pss compared to other connective tissue diseases , especially for rd , in which the beta-galactosidase activity was significantly decreased . | NA | {
"id": "C0036421",
"name": "pss",
"pos": [
106,
109
]
} | {
"id": "C0009782",
"name": "connective tissue diseases",
"pos": [
128,
154
]
} |
using these substrates , we observed nearly identical hydrogen/deuterium isotope ratios in the product alcohol for the pyridine nucleotide/atmospheric dioxygen as well as exogenous oxidant supported hydroxylations , suggesting that these reactions share a common hydrogen-abstracting species . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
63,
72
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
263,
271
]
} |
the high-density ( 1.46 ) fraction appeared homogeneous by exclusion chromatography and recentrifugation in csbr and had an amino acid composition characteristic of a mucin-type structure ( threonine , serine , proline , glycine , and alanine comprise two-thirds of the amino acid residues ) . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
221,
228
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
270,
280
]
} |
the high-density ( 1.46 ) fraction appeared homogeneous by exclusion chromatography and recentrifugation in csbr and had an amino acid composition characteristic of a mucin-type structure ( threonine , serine , proline , glycine , and alanine comprise two-thirds of the amino acid residues ) . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
235,
242
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
270,
280
]
} |
the low-density fraction had an amino acid composition distinct from that of the high-density fraction ( threonine , serine , proline , glycine , and alanine comprise 51 % of the amino acid residues ) and a lower sulfate content . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
136,
143
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
179,
189
]
} |
the low-density fraction had an amino acid composition distinct from that of the high-density fraction ( threonine , serine , proline , glycine , and alanine comprise 51 % of the amino acid residues ) and a lower sulfate content . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
150,
157
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
179,
189
]
} |
neutral lipids ( mono- , di- , and triglycerides , cholesterol , and cholesteryl esters ) comprised 56 % of weight of the total lipid . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
51,
62
]
} | {
"id": "C0008387",
"name": "cholesteryl esters",
"pos": [
69,
87
]
} |
the amino acid analyses of a63 and a13 show that both of these proteins have high proportions of acidic and basic amino acid residues , a property characteristic of the high mobility group proteins isolated from vertebrate tissues . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
4,
14
]
} | {
"id": "C0301714",
"name": "basic amino acid",
"pos": [
108,
124
]
} |
the binding specificity of the rabbit liver galactose/n-acetylgalactosamine specific lectin was studied with these neoglycoproteins by assaying their ability to inhibit 125i-labeled asialoorosomucoid binding to the isolated lectin or to the crude plasma membrane . | NA | {
"id": "C0607430",
"name": "binding",
"pos": [
4,
11
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
224,
230
]
} |
the predominant isoenzyme in the youngest circulating red blood cells , reticulocytes , has the same isoelectric point as the single enzyme of lymphoblasts . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
16,
25
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
133,
139
]
} |
this lymphoblast-like enzyme is diminished in older red cells , and the major fraction of hgprt activity is recovered in the two more acidic isoenzymes . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
22,
28
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
141,
151
]
} |
we infer that the three major red cell isoenzymes , i-iii , correspond to enzyme species with none ( alpha alpha ) , one ( alpha alpha ' ) , or both ( alpha ' alpha ' ) subunits modified . | NA | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
39,
49
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
74,
80
]
} |
three bacterial flavoprotein monooxygenases , p-hydroxybenzoate hydroxylase , orcinol hydroxylase , and salicylate hydroxylase , have been examined for steady-state kinetic isotope effects with ( 4r ) - [ 4-2h ] nad ( p ) h and ( 4r ) - [ 4-3h ] nad ( p ) h . | NA | {
"id": "C0020364",
"name": "monooxygenases",
"pos": [
29,
43
]
} | {
"id": "C0000500",
"name": "p-hydroxybenzoate hydroxylase",
"pos": [
46,
75
]
} |
suppression of approximately 83 % of the intrinsic isotope effects in the overall reaction rate ( e.g. , kh/kd = 10 down to dv = 2.5 ) corroborates earlier kinetic data on p-hydroxybenzoate hydroxylase [ husain , m. , & massey . v. ( 1979 ) j. biol . chem . 254 , 6657 ] and suggests that these bacterial phenolic monooxygenases balance out internal transition states such that no single barrier is fully rate limiting . | NA | {
"id": "C0000500",
"name": "p-hydroxybenzoate hydroxylase",
"pos": [
172,
201
]
} | {
"id": "C0020364",
"name": "monooxygenases",
"pos": [
314,
328
]
} |
the pattern of intermediate products generated during the action of chicken erythrocyte topoisomerase on a supercoiled closed circular dna substrate has been examined quantitatively and has been shown to be consistent with a mechanism in which the enzyme closes its substrate dna molecular after the removal of each superhelical turn and in which dissociation of the enzyme substrate complex may , but does not necessarily , occur after each cycle of the reaction . | NA | {
"id": "C0012925",
"name": "circular dna",
"pos": [
126,
138
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
276,
279
]
} |
brief blue-green light exposure of rhodopsin-phospholipid membrane vesicles that contained divalent cations released the cations from the vesicles . | NA | {
"id": "C0007448",
"name": "divalent cations",
"pos": [
91,
107
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
121,
128
]
} |
secondary structural effects are also found to produce shifts in the resonances of the sialic acid adjacent to the galnac residue of gm2 and the more complex gangliosides , leading to inequivalence of the sialic acids in gd1a , gd1b , and gt1b . | NA | {
"id": "C0067762",
"name": "sialic acid",
"pos": [
87,
98
]
} | {
"id": "C0037025",
"name": "sialic acids",
"pos": [
205,
217
]
} |
the rates and amplitudes of the fluorescence transitions are different for adp and amp-pnp and in turn can be distinguished from the corresponding steps involved in adenosine 5'-triphosphate ( atp ) binding . | NA | {
"id": "C0001506",
"name": "amp-pnp",
"pos": [
83,
90
]
} | {
"id": "C0001480",
"name": "adenosine 5",
"pos": [
165,
176
]
} |
poly ( u ) , poly ( a , u ) ( random copolymer ) , poly ( a-u ) ( alternating copolymer ) , poly ( a ) . poly ( u ) ( double stranded ) , and poly ( u ) . poly ( a ) . poly ( u ) ( triple stranded ) were reacted with hmt at different temperatures and salt concentrations . | NA | {
"id": "C0032402",
"name": "poly ( a-u",
"pos": [
51,
61
]
} | {
"id": "C0032400",
"name": "poly ( a",
"pos": [
13,
21
]
} |
low concentrations of fatty acids inhibited initial ca uptake by sarcoplasmic reticulum vesicles , the extent of inhibition varying with chain length and unsaturation in a series of c14-c20 fatty acids . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
22,
33
]
} | {
"id": "C0015690",
"name": "unsaturation",
"pos": [
154,
166
]
} |
when the fatty acids were added later , during the phase of spontaneous ca release that follow ca uptake in reactions carried out at 25 degrees c 1-4 microm oleic and stearic acids caused ca content to increase . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
9,
20
]
} | {
"id": "C0038230",
"name": "stearic acids",
"pos": [
167,
180
]
} |
we have investigated the effect of cyclic amp on hepatic amino acid transport by measuring the uptake of l-alanine in plasma membrane vesicles purified from hepatocytes incubated without or with dibutyryl cyclic amp . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
35,
45
]
} | {
"id": "C0012054",
"name": "dibutyryl cyclic amp",
"pos": [
195,
215
]
} |
the function of the hydroxyl group of the tyrosine residue readily nitrated by tetranitromethane ( tyrosine-105 ) in the rtem plasmid-derived beta-lactamase ( penicillinase ; penicillin amido beta-lactam-hydrolase , ec 3.5.1.6 ) from e. coli and in bacillus cereus beta-lactamase i has been investigated by chemical modification methods . | NA | {
"id": "C0030841",
"name": "penicillinase",
"pos": [
159,
172
]
} | {
"id": "C0597979",
"name": "beta-lactam-hydrolase",
"pos": [
192,
213
]
} |
all of the compounds inhibited phosphorylase a less than phosphorylase b , except 2',3',4',5,5'-pentachloro-2-biphenylol , which was equally effective on each enzyme . | NA | {
"id": "C0017916",
"name": "phosphorylase",
"pos": [
31,
44
]
} | {
"id": "C0031711",
"name": "phosphorylase b",
"pos": [
57,
72
]
} |
these findings indicate that bovine aortic endothelial cells in culture secrete mainly a urokinase-like plasminogen activator , and not a tissue-type plasminogen activator as was generally assumed . | NA | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
104,
125
]
} | {
"id": "C0032143",
"name": "tissue-type plasminogen activator",
"pos": [
138,
171
]
} |
thus , the extensive action of the glucoamylase on potato starch exposed the 6-posphorylglucosyl residue of the starch at the non-reducing terminal and large molecular weight limit dextrins remained . | NA | {
"id": "C0038179",
"name": "starch",
"pos": [
58,
64
]
} | {
"id": "C0011808",
"name": "dextrins",
"pos": [
181,
189
]
} |
apolipoproteins c-iii and d measured by electroimmunoassay are 3.2 +/- 1.2 % and 1.15 +/- 0.6 % , respectively , of the proteins found in the density range 1.030-1.055 g/ml , so there is , therefore , about 1 mol of apolipoprotein c-iii and 0.1 mol of apolipoprotein d per mol of apolipoprotein b . | NA | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
0,
14
]
} | {
"id": "C0003593",
"name": "apolipoprotein",
"pos": [
280,
294
]
} |
different methods of incorporating esterified [ 3h ] cholesterol into human high density lipoproteins ( hdl ) have been assessed in terms of their influence on the subsequent rate at which esterified [ 3h ] cholesterol was transferred from hdl to other plasma lipoproteins in 37 degrees c incubations containing tracer amounts of the labelled preparations added to aliquots of a common pool of unlabelled human plasma . | NA | {
"id": "C0023822",
"name": "cholesterol",
"pos": [
53,
64
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
207,
218
]
} |
adrenergic ligands competed with [ 3h ] hydroxybenzylisoproterenol binding with the following order of potency = ( - ) -propranolol greater than ( - ) -isoproterenol greater than ( - ) -norepinephrine approximately ( - ) -epinephrine greater than greater than ( + ) -isoproterenol = ( + ) -propranolol , which is consistent with binding to beta 1-adrenergic receptors . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
186,
200
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
222,
233
]
} |
this study describes the effect of fluoride ingestion ( 10 mg naf/kg body weight per day ) for up to 180 days , on the biosynthesis , maturation and degradation of rabbit skin collagen . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
35,
43
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
62,
65
]
} |
the enzyme was identified with rat liver alanine-glyoxylate aminotransferase isoenzyme 2 but not with rat liver alanine-glyoxylate aminotransferase isoenzyme 1 from ouchterlony double diffusion analysis . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
4,
10
]
} | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
148,
157
]
} |
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