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the 5-hete product has a triene spectrum similar to that of 5 ( s ) , 12 ( s ) -di-hete , whereas the 15- and 12-hete products exhibited single ultraviolet absorption maxima , indicating a metabolic pathway for 5-hete distinct from the other mono-hetes . | NA | {
"id": "C0044800",
"name": "12-hete",
"pos": [
110,
117
]
} | {
"id": "C0020349",
"name": "hetes",
"pos": [
247,
252
]
} |
the epitope-specific regulatory system selectively controls igg antibody production to the individual ( haptenic ) determinants on a complex antigen . | NA | {
"id": "C0018593",
"name": "haptenic",
"pos": [
104,
112
]
} | {
"id": "C0003316",
"name": "determinants",
"pos": [
115,
127
]
} |
thus , studies presented show that priming with an antigenic ( carrier ) molecule simultaneously prepares the animal for the production of typical secondary ( anamnestic ) antibody responses to epitopes on the priming antigen and for the induction of epitope-specific suppression for antibody production to determinants presented subsequently on the same antigenic molecule . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
194,
201
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
355,
364
]
} |
antibody responses to commonly used antigens are regulated by an epitope- specific system composed of igh-restricted elements responsible for controlling the isotype and allotype responses mounted to each of the epitopes on the antigen . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
0,
8
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
158,
165
]
} |
antibody responses to commonly used antigens are regulated by an epitope- specific system composed of igh-restricted elements responsible for controlling the isotype and allotype responses mounted to each of the epitopes on the antigen . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
212,
220
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
228,
235
]
} |
the operation of such a mechanism permits conditions surrounding the first immunization with an epitope ( hapten ) to strongly influence but not absolutely determine which and how many of the anti-epitope memory b cells generated by that immunization will subsequently be expressed . | NA | {
"id": "C0018593",
"name": "hapten",
"pos": [
106,
112
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
197,
204
]
} |
it was shown that acidification by itself is insufficient for the complete conversion of colourless porphyrinogens into porphyrins in photometric determination of porphyrins in diluted urine . | NA | {
"id": "C0032711",
"name": "porphyrinogens",
"pos": [
100,
114
]
} | {
"id": "C0032712",
"name": "porphyrins",
"pos": [
163,
173
]
} |
a sensitive assay for the determination of four different barbiturates : butabarbital , cyclobarbital , pentobarbital and secobarbital is described . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
58,
70
]
} | {
"id": "C0030883",
"name": "pentobarbital",
"pos": [
104,
117
]
} |
a sensitive assay for the determination of four different barbiturates : butabarbital , cyclobarbital , pentobarbital and secobarbital is described . | NA | {
"id": "C0004745",
"name": "barbiturates",
"pos": [
58,
70
]
} | {
"id": "C0036516",
"name": "secobarbital",
"pos": [
122,
134
]
} |
the adult hemoglobins of 15 species of teleost and the midgestation fetal hemoglobin of the seaperch embiotoca lateralis show a pronounced decrease in oxygen-carrying capacity at low ph , a root effect . | NA | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
10,
21
]
} | {
"id": "C0015936",
"name": "fetal",
"pos": [
68,
73
]
} |
in streptomyces glaucescens , the intracellular and the extracellular enzyme forms of tyrosinase were found to be indentical in molecular weight ( 29 000 ) , in copper content ( 0.21 % ) , in the 19 amino acids at the amino-terminal end and in the ratio of cresolase to catecholase activity ( 0,005 ) . | NA | {
"id": "C0012524",
"name": "tyrosinase",
"pos": [
86,
96
]
} | {
"id": "C0041484",
"name": "cresolase",
"pos": [
257,
266
]
} |
a-alanine at concentrations higher than 0.7 g 1 ( -1 ) was responsible for the inhibition of k99 synthesis observed on media rich in amino acids . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
2,
9
]
} | {
"id": "C0002520",
"name": "amino",
"pos": [
133,
138
]
} |
therefore , the procedure of loosening of nucleoproteins used in this report also preserves the active sv40 chromatin and allows the in situ visualization in epon sections of transcription and replication of the virus genome . | NA | {
"id": "C0028612",
"name": "nucleoproteins",
"pos": [
42,
56
]
} | {
"id": "C0008546",
"name": "chromatin",
"pos": [
108,
117
]
} |
in these cases , virus production with attendant cytopathic effect in the fibroblasts required the continuous presence of macrophages because the cells reverted to a non-productive state when separated from macrophages and became productive again when subcultures were added to new macrophages . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
74,
85
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
146,
151
]
} |
such activations could contribute to reestablish sufficient release of da when the dopaminergic function is impaired as in parkinson 's disease . | NA | {
"id": "C0013030",
"name": "da",
"pos": [
71,
73
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
83,
95
]
} |
brain na was largely and relatively selectively depleted , particularly in area innervated by the lc , by pretreatment with an injection of 6-hydroxydopamine ( 6-ohda , 200 microgram ) into the right lateral ventricle 7 days before the induction of an acute hypertensive reaction by intravenously administered angiotensin or adrenaline in conscious , unrestrained rats with indwelling catheters in the aorta and a jugular vein . | NA | {
"id": "C0028351",
"name": "na",
"pos": [
6,
8
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
325,
335
]
} |
the dipeptide carnosine ( beta-alanyl-l-histidine ) has been proposed as a neurotransmitter in the mammalian olfactory pathway . | NA | {
"id": "C0012512",
"name": "dipeptide",
"pos": [
4,
13
]
} | {
"id": "C0007267",
"name": "carnosine",
"pos": [
14,
23
]
} |
the molecular weights of these lectin-reactive bands were estimated by comparison with radioiodinated protein standards by using the linear relationship between log of the molecular weight and log of the gel concentration reached by the protein after electrophoresis in a polyacrylamide gradient gel . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
31,
37
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
237,
244
]
} |
the density of alpha-lt receptors [ which are probably composed of , or include , membrane protein ( s ) ] varies between 0.6 and 0.88 pmol/mg of synaptosome protein , their affinity is very high ( ka of the order of 10 ( 10 ) m-1 ) , their association rate is fast , and their dissociation rate slow . | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
82,
98
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
158,
165
]
} |
oat was inhibited by gaba to a considerably greater extent than by glu , l-glutamine , or put ; | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
67,
70
]
} | {
"id": "C0017797",
"name": "l-glutamine",
"pos": [
73,
84
]
} |
experiments were designed to test the hypothesis that ganglionic butyrylcholinesterase ( buche ) is derived from acetylcholinesterase ( ache ) . | NA | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
65,
86
]
} | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
113,
133
]
} |
at intervals of 1 h and 1 , 2 , 3 , 6 , 11 , and 22 days later , they were killed , and the ache and buche contents of both scg and both stellate ganglia ( stg ) were assayed . | NA | {
"id": "C0001044",
"name": "ache",
"pos": [
92,
96
]
} | {
"id": "C0008429",
"name": "buche",
"pos": [
101,
106
]
} |
hence , the regeneration of buche appears to be independent of the presence of ache in the neuropil . | NA | {
"id": "C0008429",
"name": "buche",
"pos": [
28,
33
]
} | {
"id": "C0001044",
"name": "ache",
"pos": [
79,
83
]
} |
the phosphorylcholine concentration of rat brain rises and falls in response to parallel changes in the concentration of circulating choline . | NA | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
4,
21
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
133,
140
]
} |
a single oral dose of choline chloride ( 20 mmol/kg ) elevated whole-brain concentrations of both choline and phosphorylcholine 5 h after administration ; | NA | {
"id": "C0008409",
"name": "choline chloride",
"pos": [
22,
38
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
120,
127
]
} |
a single oral dose of choline chloride ( 20 mmol/kg ) elevated whole-brain concentrations of both choline and phosphorylcholine 5 h after administration ; | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
22,
29
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
110,
127
]
} |
striatal phosphorylcholine concentrations were elevated within 2 h of choline administration and continued to be significantly greater than control values for up to 34 h after treatment . | NA | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
9,
26
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
70,
77
]
} |
the response of striatal choline levels to exogenous choline was of shorter duration than that of phosphorylcholine and was correlated with a significant increase in striatal acetylcholine concentrations . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
25,
32
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
98,
115
]
} |
the consumption of a choline-free diet for 7 days lowered both serum choline and striatal phosphorylcholine concentrations , but had no effect on striatal choline or acetylcholine . | NA | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
90,
107
]
} | {
"id": "C0008405",
"name": "choline",
"pos": [
172,
179
]
} |
neurotensin ( nt ) is an endogenous neuropeptide that is active in many preclinical screening tests for neuroleptic drugs . | NA | {
"id": "C0027930",
"name": "neurotensin",
"pos": [
0,
11
]
} | {
"id": "C0027895",
"name": "neuropeptide",
"pos": [
36,
48
]
} |
a possible correlation between the changes in cholesterol esters and cholesterol of the brain and serum in eae is suggested . | NA | {
"id": "C0008387",
"name": "cholesterol esters",
"pos": [
46,
64
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
69,
80
]
} |
analysis of [ 3h ] proline incorporation demonstrated a 4-fold increase in [ 3h ] hydroxyproline released into the medium of duchenne myogenic cell clones while intracellular [ 3h ] hydroxyproline levels showed normal values . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
19,
26
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
182,
196
]
} |
the effects of mitogenic lectins phytohemagglutinin ( pha ) , and concanavalin a ( con a ) on the growth rate of cells derived from glial tumors ( astrocytoma , ependymoma , glioblastoma , medulloblastoma , and c6 rat glioma ) , neural crest tumors ( neuroblastoma and schwannoma ) , and meningiomas were studied . | NA | {
"id": "C0004114",
"name": "astrocytoma",
"pos": [
147,
158
]
} | {
"id": "C0017636",
"name": "glioblastoma",
"pos": [
174,
186
]
} |
the effects of mitogenic lectins phytohemagglutinin ( pha ) , and concanavalin a ( con a ) on the growth rate of cells derived from glial tumors ( astrocytoma , ependymoma , glioblastoma , medulloblastoma , and c6 rat glioma ) , neural crest tumors ( neuroblastoma and schwannoma ) , and meningiomas were studied . | NA | {
"id": "C0014474",
"name": "ependymoma",
"pos": [
161,
171
]
} | {
"id": "C0017638",
"name": "glioma",
"pos": [
218,
224
]
} |
the effects of mitogenic lectins phytohemagglutinin ( pha ) , and concanavalin a ( con a ) on the growth rate of cells derived from glial tumors ( astrocytoma , ependymoma , glioblastoma , medulloblastoma , and c6 rat glioma ) , neural crest tumors ( neuroblastoma and schwannoma ) , and meningiomas were studied . | NA | {
"id": "C0025149",
"name": "medulloblastoma",
"pos": [
189,
204
]
} | {
"id": "C0017638",
"name": "glioma",
"pos": [
218,
224
]
} |
five monoclonal antibodies were selected by immunizing mice with embryonic chick optic nerve and screening the resultant hybridoma antibodies by immunofluorescence on sections of the retina . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
5,
26
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
131,
141
]
} |
the dose responses of canine basilar arteries to human hemoglobin , rabbit hemoglobin , horse-heart myoglobin , and human methemoglobin and cyanomethemoglobin are compared in this paper . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
55,
65
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
145,
158
]
} |
in a consecutive operative series of 115 intracranial arteriovenous malformations ( avm 's ) , 16 occupied the medial occipital region . | NA | {
"id": "C0007772",
"name": "intracranial arteriovenous",
"pos": [
41,
67
]
} | {
"id": "C0003857",
"name": "avm 's",
"pos": [
84,
90
]
} |
the use of brain retractors in intracranial operations may lead to focal cerebral ischemia and thereby cause brain infarction . | NA | {
"id": "C0007785",
"name": "cerebral ischemia",
"pos": [
73,
90
]
} | {
"id": "C0751955",
"name": "brain infarction",
"pos": [
109,
125
]
} |
perspective views , contour maps and cross-sectional views of the response surfaces constructed from the equations revealed 1 ) that both body weight gain and protein gain increased with an increase in the metabolizable energy of dietary protein , and were not much affected by the calorie ratio of dietary carbohydrate to fat , showing a convex configuration of the response surfaces ; | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
159,
166
]
} | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
230,
245
]
} |
2 ) that fat gain decreased and appeared to become more dependent on the calorie ratio of dietary protein , fat and carbohydrate were replaceable with one another in the range of 40-50 % protein metabolizable energy with respect to body weight gain and protein gain , while replaceability of fat and carbohydrate with each other seemed to decrease with an increase in protein metabolizable energy with respect to fat gain . | NA | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
90,
105
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
368,
375
]
} |
the efficiency of utilization of the chinese mixed diet protein was 73-77 % of the egg protein , based on relative n requirements . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
56,
63
]
} | {
"id": "C0013700",
"name": "egg protein",
"pos": [
83,
94
]
} |
the prolonged fast could be divided into 3 phases with respect to liver glycogen variation : initial glycogen depletion , glycogen resurgence , and final glycogen depletion . | NA | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
66,
80
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
154,
162
]
} |
the simultaneous occurrence of increasing liver glycogen , increasing liver tyrosine aminotransferase activity , and decreasing body fat during glycogen resurgence suggests that the young adult rat does not spare body protein during starvation . | NA | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
42,
56
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
144,
152
]
} |
during the final glycogen depletion phase , liver glycogen was again present in a lobular gradient ( p greater than m greater than c ) but the absolute amount of glycogen in each region of the lobule was markedly reduced in comparison with rats killed during glycogen resurgence . | NA | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
44,
58
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
259,
267
]
} |
local immunologic responses were studied in eleven patients with periodontitis , ten patients with juvenile periodontitis , and ten control subjects by performing immunofluorescence on gingival biopsies . | NA | {
"id": "C0031099",
"name": "periodontitis",
"pos": [
65,
78
]
} | {
"id": "C0031106",
"name": "juvenile periodontitis",
"pos": [
99,
121
]
} |
these findings support our previous conclusion that immunologic responses in periodontitis and juvenile periodontitis appear qualitatively similar , but that patients with juvenile periodontitis exhibit a more intense immune response . | NA | {
"id": "C0031099",
"name": "periodontitis",
"pos": [
77,
90
]
} | {
"id": "C0031106",
"name": "juvenile periodontitis",
"pos": [
172,
194
]
} |
the local anesthetic effect of tetracaine in polylactic acid microspheres was compared with that of tetracaine hydrochloride solutions . | NA | {
"id": "C0039629",
"name": "tetracaine",
"pos": [
31,
41
]
} | {
"id": "C0304456",
"name": "tetracaine hydrochloride",
"pos": [
100,
124
]
} |
leukotriene d4 at 5 to 50 ng/ml ( concentrations relevant to srs-a release ) showed a concentration-dependent inhibition of srs-a release , but no effect on histamine release . | NA | {
"id": "C0023544",
"name": "leukotriene d4",
"pos": [
0,
14
]
} | {
"id": "C0038091",
"name": "of srs-a",
"pos": [
121,
129
]
} |
leukotriene c4 at 5 to 50 ng/mg failed to significantly alter the amount of srs-a release . | NA | {
"id": "C0023542",
"name": "leukotriene c4",
"pos": [
0,
14
]
} | {
"id": "C0038091",
"name": "of srs-a",
"pos": [
73,
81
]
} |
riboflavin was accumulated by rabbit renal slices by a transport system that was inhibited by sugar-containing and sugarless flavins , cyclic organic acids including aminohippurate and penicillin , dinitrophenol and cold temperatures , but not by d-ribose or the weak base tolazoline . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
0,
10
]
} | {
"id": "C0016213",
"name": "flavins",
"pos": [
125,
132
]
} |
simultaneous infusion with the angiotensin ii antagonist , saralasin , potentiated the rise in plasma renin level and blocked the rise in blood pressure . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
31,
45
]
} | {
"id": "C0036193",
"name": "saralasin",
"pos": [
59,
68
]
} |
this study investigated the effects of three types of laboratory stressors ( stressful imagery , mental arithmetic , pain ) on temporal artery , skeletal muscle , general autonomic [ digital blood volume pulse ( dbvp ) , spontaneous resistance responses ( srr 's ) ] and self-report measures of distress in chronic migraine , mixed , muscle contraction and non-headache controls . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
117,
121
]
} | {
"id": "C0018681",
"name": "headache",
"pos": [
361,
369
]
} |
using standardized methods for protein extraction and analysis , the testes of rams , bulls , goats , boars , stallions , rats , cats , hedgehogs , european mink and ferrets were examined for basic spermatid nucleoproteins by electrophoresis . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
31,
38
]
} | {
"id": "C0028612",
"name": "nucleoproteins",
"pos": [
208,
222
]
} |
the results of 200 antenatal diagnoses in pregnancies at risk for homozygous beta-thalassaemia , carried out on fetal blood samples obtained by placental aspiration in the second trimester , are described . | NA | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
42,
53
]
} | {
"id": "C0032980",
"name": "second trimester",
"pos": [
172,
188
]
} |
these effects appear to be specific for the methotrexate-tetrahydrofolate carrier system since the transport of other compounds which utilize this carrier , aminopterin , 5-methyltetrahydrofolate , and 5-formyltetrahydrofolate , is affected similarly to methotrexate , whereas , the transport of folic acid , a compound similar in structure and charge but not significantly transported by this carrier is unaffected by liposomes . | NA | {
"id": "C0002583",
"name": "aminopterin",
"pos": [
157,
168
]
} | {
"id": "C0025677",
"name": "methotrexate",
"pos": [
254,
266
]
} |
a patient is described illustrating some of these factors , in which exposure to noise , head injury , ototoxic drug ingestion , childhood ear disease , otosclerosis , and presbycusis compounded to create a clinical conundrum . | NA | {
"id": "C0013447",
"name": "ear disease",
"pos": [
139,
150
]
} | {
"id": "C0029899",
"name": "otosclerosis",
"pos": [
153,
165
]
} |
the relative amounts of [ ( 3 ) h ] mannose in the complex , high-mannose-type , and intermediate glycans were 25 , 62 , and 13 % , respectively , which corresponded to the approximate relative number of oligosaccharide chains of 2:2.8:1 , respectively , in the roughly equimolar mixture of g1 and g2 . | NA | {
"id": "C0032594",
"name": "glycans",
"pos": [
98,
105
]
} | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
204,
219
]
} |
we found that the subgenomic mrna 's that direct the synthesis of the env and src gene products have uninterrupted spliced leader sequences of approximately 390 nucleotides , whereas virion rna and full-length intracellular viral rna have 5 ' termini homologous to the cloned viral dna probe over at least the first 735 bases . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
30,
33
]
} | {
"id": "C0035736",
"name": "viral rna",
"pos": [
224,
233
]
} |
in the case of akr-623 dna , a 3- or 4-base-pair direct repeat of cellular sequences flanking the viral dna was observed . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
23,
26
]
} | {
"id": "C0012939",
"name": "viral dna",
"pos": [
98,
107
]
} |
the endogenous viral dna sequences were nontandem , uninterrupted , and colinear with the dna of the infectious virus , and they were integrated at different sites in the baboon dna , like the m7 proviral dna sequences acquired upon infection . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
15,
24
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
205,
208
]
} |
the hr mutant-transformed cells , unlike wild-type virus transformants , were fibroblastic rather than epithelial , failed to grow in soft agar , and were also less tumorigenic in nude mice . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
26,
31
]
} | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
78,
90
]
} |
there was no detectable homology between sis and the cell-derived sequences of other fibroblast-transforming retroviruses . | NA | {
"id": "C0007634",
"name": "the cell",
"pos": [
49,
57
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
85,
95
]
} |
kartagener 's syndrome , characterized by situs inversus , paranasal sinusitis , and bronchiectasis , is part of a more generalized syndrome characterized by sterility in men , chronic bronchitis or bronchiectasis , chronic sinusitis , and chronic otitis media ; | NA | {
"id": "C0022521",
"name": "kartagener 's syndrome",
"pos": [
0,
22
]
} | {
"id": "C0006267",
"name": "bronchiectasis",
"pos": [
199,
213
]
} |
these results suggest that , since the enhanced response to infused dopamine may reflect reduced dopaminergic activity , attenuation of renal dopaminergic activity might exist and be involved through a distribution of water-sodium metabolism , at least in part , in the pathophysiological mechanism in eht , particularly in group l . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
68,
76
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
142,
154
]
} |
thirty-five patients with secundum atrial septal defect ( asd ) were studied with cross-sectional echocardiography for detection of the asd defect and demonstration of the ias features following asd closure . | NA | {
"id": "C0016522",
"name": "secundum",
"pos": [
26,
34
]
} | {
"id": "C0018817",
"name": "asd",
"pos": [
195,
198
]
} |
it may be suggested on the basis of these experimental results that 1 ) the muscarinic ach receptor of bullfrog atrial muscle may compose a receptor-ionic channel complex ( ricc ) with voltage-dependent ca2+ channel and 2 ) the molecular reaction between this ricc and agonist may be comparable to that occurring in the nicotinic ricc of the frog end-plate . | NA | {
"id": "C0034792",
"name": "ach receptor",
"pos": [
87,
99
]
} | {
"id": "C0034830",
"name": "nicotinic ricc",
"pos": [
320,
334
]
} |
intracerebroventricular ( i.c.v . ) injection of c-terminal octapeptide of cholecystokinin ( cck-8 ) in rats prolonged pentobarbital- and ethanol-induced sleeping time , but non-sulfated ccd-8 ( cck-8-ns ) had no effect and caerulein showed a tendency to prolong the pentobarbital narcosis . | NA | {
"id": "C0037167",
"name": "octapeptide",
"pos": [
60,
71
]
} | {
"id": "C0008328",
"name": "cck-8",
"pos": [
195,
200
]
} |
a correlation analysis was made between the data adrenalin excretion , noradrenalin , dopamine and dopa in the urine and renin activity in the blood . | NA | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
49,
58
]
} | {
"id": "C0028351",
"name": "noradrenalin",
"pos": [
71,
83
]
} |
a detailed study of 44 patients with the neuro-vascular compression syndrome of thoracic exit has established the diagnostic value of clinical and special methods of diagnosing the disease . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
68,
76
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
181,
188
]
} |
the main indications for assisted circulation were cardiogenic shock in 102 patients , myocardial infarction complicated by cardiac insufficiency in 43 , cardiac insufficiency developing during or after cardiosurgical operations in 60 cases , prophylaxis of complications in high risk patients during intracardiac methods of investigation in 4 cases . | NA | {
"id": "C0036980",
"name": "cardiogenic shock",
"pos": [
51,
68
]
} | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
87,
108
]
} |
in both groups plasma and urinary norepinephrine or epinephrine values were not significantly altered following addition of a beta-blocker ; | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
34,
48
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
52,
63
]
} |
it allows to analyze the immunoglobulin classes of the reacting antibodies and their complement fixation ability in vitro . | NA | {
"id": "C0021017",
"name": "immunoglobulin classes",
"pos": [
25,
47
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
64,
74
]
} |
low-density lipoprotein ( ldl ) receptors are demonstrable in cultured fibroblasts from normal subjects but are decreased or absent in cells from patients with heterozygous or homozygous familial hypercholesterolaemia . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
71,
82
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
135,
140
]
} |
the extent of cross reactivity between antisera to human complement proteins [ the third ( c3 ) and fourth ( c4 ) components and factor b ( bf ) ] and these proteins in the sera of six species of nonhuman primates was examined . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
57,
67
]
} | {
"id": "C0033453",
"name": "factor b",
"pos": [
129,
137
]
} |
in semi quantitative determinations , the emit tox test was applied to 139 sera with one or more of the three benzodiazepines ( oxazepam , desmethyldiazepam , diazepam ) , showing a significant correlation with levels measured by gas chromatography ; | NA | {
"id": "C0011279",
"name": "desmethyldiazepam",
"pos": [
139,
156
]
} | {
"id": "C0012010",
"name": "diazepam",
"pos": [
159,
167
]
} |
the order of competitive potency for the first three preparations was found to be medroxyprogesterone greater than deoxycorticosterone greater than progesterone greater than r-5020 greater than cortexolone greater than 17-hydroxyprogesterone . | NA | {
"id": "C0025147",
"name": "medroxyprogesterone",
"pos": [
82,
101
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
219,
241
]
} |
the order of competitive potency for the first three preparations was found to be medroxyprogesterone greater than deoxycorticosterone greater than progesterone greater than r-5020 greater than cortexolone greater than 17-hydroxyprogesterone . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
89,
101
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
219,
241
]
} |
the order for the glucocorticoid receptor of liver , on the other hand , was r-5020 greater than progesterone greater than deoxycorticosterone greater than medroxyprogesterone greater than cortexolone greater than 17-hydroxyprogesterone . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
97,
109
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
214,
236
]
} |
the order for the glucocorticoid receptor of liver , on the other hand , was r-5020 greater than progesterone greater than deoxycorticosterone greater than medroxyprogesterone greater than cortexolone greater than 17-hydroxyprogesterone . | NA | {
"id": "C0025147",
"name": "medroxyprogesterone",
"pos": [
156,
175
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
214,
236
]
} |
monkeys immunized with the beta-subunit of ovine luteinizing hormone ( olh beta ) develop antibodies which cross react with rhesus chorionic gonadotropin ( rhcg ) and luteinizing hormone ( rhlh ) . | NA | {
"id": "C0065261",
"name": "beta-subunit",
"pos": [
27,
39
]
} | {
"id": "C0023607",
"name": "luteinizing hormone",
"pos": [
167,
186
]
} |
in the present study , we have measured the effects of circulating olh beta-antibodies on peripheral estradiol , progesterone and 17 alpha oh-progesterone ( 17oh-p ) concentrations throughout the menstrual cycle and during gestation in monkeys which became pregnant following mpa-treatment . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
113,
125
]
} | {
"id": "C0020387",
"name": "17",
"pos": [
157,
159
]
} |
it is concluded that in pregnancy ( 1 ) hypothalamic control of maternal adrenal secretion still prevails , ( 2 ) the increase in total cortisol is essentially due to that of cbg , ( 3 ) the unbound cortisol is normal or , at times , slightly increased and ( 4 ) variations in the pt/true cbg ratios may be explained by the presence of steroids ( progesterone and 17-oh-progesterone ) with a high affinity for cbg . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
347,
359
]
} | {
"id": "C0020387",
"name": "17-oh-progesterone",
"pos": [
364,
382
]
} |
different doses of 4-app up to 25 mg/kg bw and up to 4 days of treatment , however , did not modulate cholesterol and cholesterol ester contents of isolated leydig cells . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
102,
113
]
} | {
"id": "C0008387",
"name": "cholesterol ester",
"pos": [
118,
135
]
} |
the major c-21-17-hydroxysteroids and c19-steroids formed from progesterone by the ovaries of 23-day-old hamsters were 5 alpha-steroids such as 3 alpha , 17-dihydroxy-5 alpha-pregnan-20-one and androsterone , whereas those by the ovaries of 28- and 60-day-old hamsters were 4-ene-3-ketosteroids and 5 beta- and 5 alpha-steroids such as 17-hydroxy-4-pregnene-3,20-dione . | NA | {
"id": "C0020393",
"name": "hydroxysteroids",
"pos": [
18,
33
]
} | {
"id": "C0038317",
"name": "steroids",
"pos": [
319,
327
]
} |
the major c-21-17-hydroxysteroids and c19-steroids formed from progesterone by the ovaries of 23-day-old hamsters were 5 alpha-steroids such as 3 alpha , 17-dihydroxy-5 alpha-pregnan-20-one and androsterone , whereas those by the ovaries of 28- and 60-day-old hamsters were 4-ene-3-ketosteroids and 5 beta- and 5 alpha-steroids such as 17-hydroxy-4-pregnene-3,20-dione . | NA | {
"id": "C0022640",
"name": "ketosteroids",
"pos": [
282,
294
]
} | {
"id": "C0038317",
"name": "steroids",
"pos": [
319,
327
]
} |
the operation alone led to a significant decrease in spermatic vein levels of pregnenolone , progesterone , 17-hydroxyprogesterone , androstenedione and testosterone in 30 min . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
93,
105
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
108,
130
]
} |
testicular steroidogenesis responded rapidly to hcg stimulation , which was reflected in elevated spermatic vein levels of pregnenolone , progesterone , 17-hydroxyprogesterone , androstenedione , testosterone and 5 alpha-dihydrotestosterone at 30 min following hcg . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
138,
150
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
153,
175
]
} |
in peripheral vein , the concentrations of pregnenolone , progesterone and 17-hydroxyprogesterone were significantly elevated at the same time . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
58,
70
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
75,
97
]
} |
ace inhibitors could thus lower blood pressure by two separate angiotensin-dependent mechanisms -- first by interfering with neurogenic vasoconstriction as outlined above , and second , by blocking the direct vasoconstrictor action of angiotensin ii . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
63,
74
]
} | {
"id": "C0003009",
"name": "angiotensin",
"pos": [
235,
246
]
} |
rats implanted with osmotic minipumps containing adrenaline ( 0.2 ml , 2.9 mm ) developed increased systolic and diastolic blood pressures , whereas blood pressures in rats implanted with osmotic minipumps containing the same amount of noradrenaline did not differ from those of sham-operated control rats . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
49,
59
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
236,
249
]
} |
plasma concentrations of adrenaline and noradrenaline released from the minipumps were 17 nm and 2.4 nm , respectively the atria accumulated 56 pmol/g of adrenaline released from the minipump . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
40,
53
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
154,
164
]
} |
four of 46 patients with carcinoid tumors and the carcinoid syndrome developed severe life-threatening diarrhea . | NA | {
"id": "C0007095",
"name": "carcinoid tumors",
"pos": [
25,
41
]
} | {
"id": "C0024586",
"name": "carcinoid syndrome",
"pos": [
50,
68
]
} |
it should be considered ( 1 ) in patients who are markedly symptomatic with refractory supraventricular tachycardia , ( 2 ) in those who have the potential for sudden cardiac death , ( 3 ) in younger patients with symptomatic tachycardia in whom there is concern about the long-term effects of antidysrhythmic treatment , and ( 4 ) in patients with tachycardia who are undergoing cardiac surgery for repair of associated conditions . | NA | {
"id": "C0039240",
"name": "supraventricular tachycardia",
"pos": [
87,
115
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
349,
360
]
} |
the prevalence of autoantibodies in selected subgroups of patients ranged from 70 % ( rheumatoid factor ) to 22 % ( anti-native dna ) . | NA | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
18,
32
]
} | {
"id": "C0035448",
"name": "rheumatoid factor",
"pos": [
86,
103
]
} |
the proportion of ea-positive and vca-positive cells increased rapidly in culture for 24 h , then the positive cells degenerated rapidly and completely . | NA | {
"id": "C0003320",
"name": "ea",
"pos": [
18,
20
]
} | {
"id": "C0003342",
"name": "vca",
"pos": [
34,
37
]
} |
the ability to make biologically active synthetic human growth hormone creates an essentially unlimited supply of growth hormone for the treatment of hypopituitarism and for the study of additional therapeutic indications . | NA | {
"id": "C0169964",
"name": "human growth hormone",
"pos": [
50,
70
]
} | {
"id": "C0037663",
"name": "growth",
"pos": [
114,
120
]
} |
the rapid modulation of the enzymic phenotype and ribonucleotide concentrations by acivicin provides a useful tool for elucidating the role of enzymic and nucleotide imbalance in the commitment of cancer cells to replication and in the targeting of anticancer chemotherapy . | NA | {
"id": "C0035548",
"name": "ribonucleotide",
"pos": [
50,
64
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
155,
165
]
} |
a 4 day half-life of dopamine beta-hydroxylase ( dbh ) was determined for rats injected iv with 125i-rat dbh from the slow exponential component of radioactivity appearing in plasma , urine , feces and combined urine and feces . | NA | {
"id": "C0020364",
"name": "hydroxylase",
"pos": [
35,
46
]
} | {
"id": "C0013032",
"name": "dbh",
"pos": [
105,
108
]
} |
when stressed by co2 to produce a respiratory acidosis or by injection of distilled water to produce brain edema , the jimpy mouse brain has water and ionic responses essentially like those in controls . | NA | {
"id": "C1163679",
"name": "injection",
"pos": [
61,
70
]
} | {
"id": "C0043047",
"name": "water",
"pos": [
141,
146
]
} |
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