text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
priming human fibroblasts with low levels ( 100 units/ml ) of homologous interferon ( ifn ) prior to induction of gene expression with poly ( ri.rc ) results in the accumulation of 5-10-fold higher levels of ifn-beta 1 mrna when compared to induced but nonprimed cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
14,
25
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
208,
216
]
} |
two groups of pathologic red cells were chosen for these studies : red cells with quantitative deficiencies of the skeletal proteins , spectrin and protein 4.1 , and sickle erythrocytes in which controlled reorganization of the membrane was induced by hemoglobin polymerization . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
25,
34
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
252,
262
]
} |
the production of 3h2o from alpha- and beta-d- [ 5-3h ] glucose and that of 14co2 from either alpha- and beta-d- [ 1-14c ] or alpha- and beta-d- [ 6-14c ] glucose were measured in rat pancreatic islets and tumoral insulin-producing cells incubated at 7 degrees c . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
184,
201
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
214,
221
]
} |
the decrease in ni in pcod and/or non-pcod secondary amenorrhea vs. the ni of the follicular phase could be explained by either a higher frequency of lhrh pulses from the hypothalamus or an increased sensitivity of the pituitary leading to a greater response of the pituitary to lhrh pulses . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
171,
183
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
279,
283
]
} |
these results suggest that a major component of plasma i-crf is of hypothalamic origin , however , other extrahypothalamic tissues can not be ruled out as a minor source of plasma i-crf . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
67,
79
]
} | {
"id": "C0010132",
"name": "i-crf",
"pos": [
180,
185
]
} |
pretreatment of human fibroblast cells with 100 u of either cloned human alpha-2 or beta interferon per ml for 24 h reduced the release of infectious herpes simplex virus type 1 by more than 99 % . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
22,
32
]
} | {
"id": "C0015980",
"name": "beta interferon",
"pos": [
84,
99
]
} |
involvement of hypothalamic somatostatin in the suppression of growth hormone secretion by central corticotropin-releasing factor in conscious male rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
15,
27
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
28,
40
]
} |
involvement of hypothalamic somatostatin in the suppression of growth hormone secretion by central corticotropin-releasing factor in conscious male rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
15,
27
]
} | {
"id": "C0010132",
"name": "corticotropin-releasing factor",
"pos": [
99,
129
]
} |
erythrocyte 2,3-diphosphoglycerate , po2 50 % and available o2 in rabbits with bleeding anaemia superimposed on the early post-natal fall in haemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
0,
11
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
141,
152
]
} |
erythrocyte 2,3-diphosphoglycerate ( 2,3-dpg ) , po2 50 % , whole blood haemoglobin ( hb ) , haematocrit ( hct ) and available o2 were determined in two matched groups of suckling rabbits from the 17th to the 34th day after birth . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
0,
11
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
72,
83
]
} |
the lesions demonstrated essentially identical cellular compositions and consisted of t-lymphocytes with a peripheral phenotype ( lyt3+ , anti-leu-4+ , okt6- ) , macrophages ( hla-dr+ , eb11+ , okm1+ ) , and langerhans cells ( hla-dr+ , okt6+ ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-lymphocytes",
"pos": [
86,
99
]
} | {
"id": "C1332717",
"name": "lyt3",
"pos": [
130,
134
]
} |
the efficacy of serum folate ( sf ) , red blood cell folate ( rcf ) , and serum b12 in diagnosing folate and b12 deficiency , and the effect of iron overload on hemoglobin , were studied in 157 cases of homozygous beta thalassemia ( hbt ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
38,
52
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
161,
171
]
} |
to test whether lymphokine ( s ) secreted by alveolar lymphocytes regulated mdgf secretion by macrophages in this model , the authors exposed normal macrophages harvested from control rat lungs to lymphokine preparations in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
54,
65
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
197,
207
]
} |
the proteinase purified from one larval form , the cercaria , degrades fibronectin and laminin and is a type-specific collagenase with activity against basement-membrane collagens iv and viii , but not interstitial collagens i , iii and v . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement-membrane",
"pos": [
152,
169
]
} | {
"id": "C0009333",
"name": "collagens iv",
"pos": [
170,
182
]
} |
we removed the brains from 5 juvenile and 5 adult male monkeys ( macaca fascicularis ) and blocked , sectioned , and prepared each hypothalamus for light microscopic immunocytochemistry for gnrh-containing cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
131,
143
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
190,
194
]
} |
the low concentration detected with anti-liver fabp antibodies is related to the different chemical forms and physiochemical properties of liver and heart fabp . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
41,
46
]
} | {
"id": "C1312696",
"name": "heart fabp",
"pos": [
149,
159
]
} |
a cell-mediated mutagenesis assay employing cultured primary sencar keratinocytes for the metabolism of promutagens , and v-79 fibroblasts as target cells for the resulting genotoxic metabolites , was used to survey the effects of murine beta-interferon ( ifn-beta ) on 7,12-dimethylbenz [ a ] anthracene ( dmba ) and benzo [ a ] pyrene ( bp ) -dependent mutagenesis and cytotoxicity . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
127,
138
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
256,
264
]
} |
in patients with thyroid residue but no metastases , undetectable serum tg ( false negative results ) occurred in 45 % of cases off therapy and in 92.9 % of cases during therapy . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
17,
24
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
72,
74
]
} |
but much remains to be learned about the neuroendocrine control of hypothalamic gnrh secretion -- an area which encompasses the mechanisms regulating the onset of puberty . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
67,
79
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
80,
84
]
} |
after 25 mg tolrestat the rbc sorbitol levels fell from 25.1 +/- 4.0 to 20.0 +/- 5.7 nmol/gm hemoglobin ( 21 % ) and after 100 mg tolrestat the level fell from 26.7 +/- 3.7 to 11.4 +/- 1.7 nmol/gm hemoglobin ( 57 % ; p less than 0.001 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
26,
29
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
197,
207
]
} |
rat pancreatic islets and insulin-producing cells of the rinm5f line were incubated for 5 min at 7 or 23 degrees c in media containing 3h2o and either l- [ 1-14c ] glucose or [ 2-14c ] alloxan . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
4,
21
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
26,
33
]
} |
this was demonstrated as an accumulation of 2 thyroid-specific proteins , thyroglobulin and thyroid peroxidase , using immunofluorescent staining methods and immunoprecipitation of biosynthetically labeled cultures . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
46,
53
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
74,
87
]
} |
the effects of substantia nigra lesions on the volume densities of islet cells and on the content of insulin and glucagon in the pancreas were examined using five groups of age-matched , sprague-dawley rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cells",
"pos": [
67,
78
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
101,
108
]
} |
eleven weeks after lesion placement , tissue was collected from all animals for the assessment of islet cell volume densities and the pancreatic content of insulin and glucagon . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cell",
"pos": [
98,
108
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
156,
163
]
} |
based on the known specificities of the antisera we conclude that alligator hypothalamic tissue contains an lh-rh-like peptide that differs from the mammalian hormone in at least the 8 position , and that alligator lh-rh may be similar to chicken lh-rh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
76,
88
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
247,
252
]
} |
the splenic sequestration of altered red cells was not inhibited by cortisone , and there was no inhibition of the sequestration of hemoglobin by either liver or spleen . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
37,
46
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
132,
142
]
} |
the bohr effect and the red cell 2-3 dpg and hb content in sherpas and europeans at low and at high altitude . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
24,
32
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
45,
47
]
} |
studies have been performed on a 12-yr-old chinese girl with compensatory erythrocytosis due to the presence of hemoglobin bethesda comprising about 45 % of the red cell hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
161,
169
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
170,
180
]
} |
a micro perifusion device for pancreatic islets allowing concomitant recordings of intermediate metabolites and insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
30,
47
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
112,
119
]
} |
red cells containing 45 % hb bethesda and 55 % hb a have increased oxygen affinity but , paradoxically , a normal bohr effect . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
0,
9
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
47,
49
]
} |
prolactin ( prl ) and growth hormone ( gh ) cells were immunostained in the anterior pituitary lobe of the california leaf-nosed bat with antisera against rat prl and gh by the unlabeled immunoperoxidase technique . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior",
"pos": [
76,
84
]
} | {
"id": "C0033371",
"name": "prl",
"pos": [
159,
162
]
} |
the only significant differences noted in the rbc from marginally-riboflavin-deficient subjects by comparison with controls , were lower glutathione reductase activities and higher concentrations of methaemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
46,
49
]
} | {
"id": "C0025635",
"name": "methaemoglobin",
"pos": [
199,
213
]
} |
incorporation of label into hypothalamic and neurohypophyseal somatostatin was unaffected by the hydration state of the animal . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
28,
40
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
62,
74
]
} |
the site of action of progesterone ( p ) in the blockade of estradiol-induced gonadotropin discharges was examined in rhesus monkeys bearing hypothalamic lesions which abolish endogenous gnrh production . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
141,
153
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
187,
191
]
} |
the frequencies of t cells with receptors for igg and t cells with receptors for igm were determined in 16 cases . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
19,
26
]
} | {
"id": "C0034790",
"name": "t cells",
"pos": [
54,
61
]
} |
carcinoma cell lines secreted only basement membrane proteins , type iv collagen , laminin and fibronectin , but not interstitial collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
35,
52
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
64,
80
]
} |
blood t lymphocytes with suppressor activity [ stable t cells , low affinity t cells and t cells with fc receptors for igg ( t gamma cells ) ] were enumerated , using rosette tests , in patients with graves ' hyperthyroidism , hashimoto 's thyroiditis , silent thyroiditis , primary hypothyroidism , graves ' ophthalmopathy and subacute thyroiditis . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t",
"pos": [
6,
7
]
} | {
"id": "C0034790",
"name": "t cells",
"pos": [
89,
96
]
} |
this difference was attributable to the proportion of erythrocyte pb bound to hemoglobin and a pb-binding protein of molecular weight 10,000 . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
54,
65
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
78,
88
]
} |
the changes in erythrocyte glycolysis following birth increase the oxygen transporting efficiency of hemoglobin at the higher oxygen tensions of the neonatal environment . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
15,
26
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
101,
111
]
} |
malaria parasites isolated from mouse erythrocytes are lysed by ferriprotoporphyrin ix chloride ( hemin ) or by a chloroquine-hemin complex in amounts that could be produced by release of less than 0.1 percent of the heme in erythrocytic hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
225,
237
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
238,
248
]
} |
in males , rbc , hb , pcv , mch , mchc , serum albumin , ferritin , iron , per cent transferrin saturation and folate means were significantly lower than the australian normal means ; | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
11,
14
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
17,
19
]
} |
in females , wbc , rbc , hb , pcv , mcv , mhc , mchc and serum ferritin means were lower than australian means ; | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
19,
22
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
25,
27
]
} |
thirteen patients with bone metastases of non-thyroidal primary origin had tg levels within the normal range . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroidal",
"pos": [
46,
55
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
75,
77
]
} |
fluctuation of hypothalamic luteinizing hormone releasing hormone and pituitary gonadotropins in laying and non-laying hens . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
15,
27
]
} | {
"id": "C0023610",
"name": "luteinizing hormone releasing hormone",
"pos": [
28,
65
]
} |
in 28 students with pb-rbc > 40 mug/100 ml , the mean red cell 2,3-diphosphoglycerate ( 2,3-dpg ) was 6.05+/-0.28 ( +/-s.e . ) , significantly higher ( p < .025 ) than the 5.25+/-0.18 of 51 students with pb-rbc < 40 mug/100 ml , although hemoglobin values were comparable ( 13.83+/-0.31 versus 13.55+/-0.20 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
23,
26
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
238,
248
]
} |
the effect of hypothalamic luteinizing hormone releasing hormone ( lh-rh ) on plasma gonadotrophin levels in normal subjects . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
14,
26
]
} | {
"id": "C0023610",
"name": "luteinizing hormone releasing hormone",
"pos": [
27,
64
]
} |
in the mediobasal hypothalamic-anterior hypothalamic-preoptic area ( mbh-aha-poa ) tissue preparations , we observed : 1 ) an infusion of 5 alpha-dhp was ineffective in stimulating lhrh release ; | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
18,
30
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
181,
185
]
} |
upon an examination of three hypothalamic tissue boundaries [ the mbh , the poa-suprachiasmatic nuclei ( poa-scn ) , and the median eminence ( me ) ] to better delineate the in vitro site of action of p4 on lhrh release , it was demonstrated that the mbh responded upon p4 infusion , whereas the poa-scn was unable to do so . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
29,
41
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
207,
211
]
} |
the regional distribution of rgrf-like immunoreactivity ( li ) in rat hypothalamus was examined according to the palkovits microdissection method and compared with that of somatostatin ( srif ) -li . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
70,
82
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
187,
191
]
} |
gel filtration chromatography revealed that hypothalamic extracts contained a major peak of rgrf-li corresponding to rgrf- ( 1-43 ) oh and two peaks of srif-li equivalent to srif- ( 1-28 ) and srif- ( 1-14 ) , respectively . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
44,
56
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
193,
197
]
} |
in order to minimize the influence of endogenous hypothalamic grf and somatostatin on the pituitary , the experiments were carried out in rats with the pituitary autotransplanted to the kidney capsule . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
49,
61
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
62,
65
]
} |
in order to minimize the influence of endogenous hypothalamic grf and somatostatin on the pituitary , the experiments were carried out in rats with the pituitary autotransplanted to the kidney capsule . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
49,
61
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
70,
82
]
} |
because peripheral blood measurements of lhrh do not reflect the pulsatile characteristics of hypothalamic lhrh secretion , and it is generally accepted that the pulse frequency of lh secretion is an index of the frequency of endogenous lhrh pulsation , we used lh pulse frequency as the indicator of lhrh pulse frequency . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
94,
106
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
301,
305
]
} |
in this study , we sought not only to define the distribution and morphological characteristics of lrh neurons within the human preoptic area and hypothalamus , but also to identify sites of initial synthesis , posttranslational conversion to the decapeptide , and storage of lrh in these neurons . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
146,
158
]
} | {
"id": "C0023610",
"name": "lrh",
"pos": [
276,
279
]
} |
treatment of ce-2 tb lymphocytes with various antibody and c , with 2000 rad gamma-irradiation , or fractionation on percoll density gradients suggested that radioresistant functions of thy-1.2+ , lyt-1.2+ , lyt-2.2- and of asialo gm1+ cells are independently involved in lati induction . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
21,
32
]
} | {
"id": "C0024297",
"name": "lati",
"pos": [
272,
276
]
} |
relationship between red blood cell uptake and methemoglobin production by nitrobenzene and dinitrobenzene in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
21,
35
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
47,
60
]
} |
incubation of [ 14c ] -m- , o- or p-dinitrobenzene , but not mononitrobenzene , with red blood cell suspensions caused a time-dependent increase in methemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
85,
99
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
148,
161
]
} |
these data indicate that red blood cell transport of nitrobenzene is not the limiting factor in methemoglobin production in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
25,
39
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
96,
109
]
} |
pretreatment with cysteamine ( 30 mg/100 g body wt , sc ) , a depletor of hypothalamic somatostatin , increased the plasma gh response to fk33-824 ( 10 micrograms/100 g body wt , iv ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
74,
86
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
87,
99
]
} |
these results suggest that gh secretion induced by the opioid peptide is mediated , at least in part , by hypothalamic grf in the rat . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
106,
118
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
119,
122
]
} |
we present the initial characterization of a novel family of genes that rearrange in t cells , but do not encode either of the defined ( alpha/beta ) subunits of the clone-specific heterodimer of the t cell receptor . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
85,
92
]
} | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
200,
215
]
} |
the data suggest that the inhibition of acth secretion during hypothermia is mediated by decreased hypothalamic secretion of avp and ot which in turn decreases the pituitary responsiveness to crf . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
99,
111
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
192,
195
]
} |
these results confirm that chronic melatonin administration delays sexual maturation of female rat , probably by retarding maturation of hypothalamic gnrh-producing cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
137,
149
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
150,
154
]
} |
in the thyroid gland , tsh stimulates camp formation , exocytosis of precursor ( noniodinated ) thyroglobulin , endocytosis of thyroglobulin , and proteolytic processing of the thyroglobulin to form thyroid hormones . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid gland",
"pos": [
7,
20
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
177,
190
]
} |
stress-induced activation of the pituitary-adrenal system appears to be mediated predominantly by hypothalamic neurons containing ovine corticotropin-releasing factor ( ocrf ) and vasopressin in the region of the paraventricular nucleus ( pvn ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
98,
110
]
} | {
"id": "C0010132",
"name": "corticotropin-releasing",
"pos": [
136,
159
]
} |
e-induced stimulation of pituitary-adrenal activity is mediated by beta adrenoceptors and involves release of crf , because it can be prevented by beta-adrenoceptor blockers and by destruction of crf neurons ( hypothalamic lesions ) , blockade of crf release ( chlorpromazine , morphine , and nembutal ) , or administration of crf antiserum . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
210,
222
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
327,
330
]
} |
the aim of the study was to investigate whether a minor insult to thyroid tissue such as fine needle aspiration is able to release thyroglobulin into the circulation and to induce the formation of antithyroglobulin antibodies . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
66,
73
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
201,
214
]
} |
in the liver , hfabp concentration was approximately 2-fold greater in females and in clofibrate-treated males than in untreated male rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
7,
12
]
} | {
"id": "C1312696",
"name": "hfabp",
"pos": [
15,
20
]
} |
intestinal hfabp turnover was 33 % greater in females than in males , whereas mrna concentration was 50 % greater . | tissue_is_expression_site_of_gene_product | {
"id": "C0021853",
"name": "intestinal",
"pos": [
0,
10
]
} | {
"id": "C1312696",
"name": "hfabp",
"pos": [
11,
16
]
} |
thus , unlike hfabp in liver , there was no sex-related difference in the steady-state level of hfabp in intestine . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
23,
28
]
} | {
"id": "C1312696",
"name": "hfabp",
"pos": [
96,
101
]
} |
however , clofibrate treatment , similar to its effects in the liver , doubled intestinal hfabp protein and mrna concentration . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
63,
68
]
} | {
"id": "C1312696",
"name": "hfabp",
"pos": [
90,
95
]
} |
however , clofibrate treatment , similar to its effects in the liver , doubled intestinal hfabp protein and mrna concentration . | tissue_is_expression_site_of_gene_product | {
"id": "C0021853",
"name": "intestinal",
"pos": [
79,
89
]
} | {
"id": "C1312696",
"name": "hfabp",
"pos": [
90,
95
]
} |
monoclonal antibody 9.6 is specific for a 50 kd t cell surface protein ( p50 ) associated with the sheep erythrocyte ( e ) -receptor on human t lymphocytes . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
48,
54
]
} | {
"id": "C0034790",
"name": "receptor",
"pos": [
124,
132
]
} |
rapid changes in growth hormone regulation and hypothalamic somatostatin after transection of anterolateral pathways to the medial-basal hypothalamus in the rat . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
47,
59
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
60,
72
]
} |
the purpose of the present studies was to see whether oestrogen and progesterone affected this increase in adrenergic activity at the sites of the cell bodies ( mpoa ) and axon terminals ( mbh ) of the gonadotrophin-releasing hormone-synthesizing neurone . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "mbh",
"pos": [
189,
192
]
} | {
"id": "C0023610",
"name": "gonadotrophin-releasing hormone",
"pos": [
202,
233
]
} |
the displacement of 125i-rat crf by serially diluted extracts of male wistar rats hypothalamus , thalamus , midbrain , pons , medulla oblongata , cerebral cortex , cerebellum and neurointermediate lobe was parallel to the displacement of synthetic rat crf . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
82,
94
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
252,
255
]
} |
in both wky and shr the highest levels of crf immunoreactivity were shown by the hypothalamus and neuro-intermediate lobe , and considerable crf immunoreactivity was also detected in other brain regions . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
81,
93
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
141,
144
]
} |
the crf immunoreactivity in the hypothalamus , neurointermediate lobe , midbrain , medulla oblongata and cerebral cortex was significantly reduced in shr and it may suggest that crf abnormality may be implicated in the reported abnormalities in the pituitary-adrenal axis , autonomic response and behavior of shr . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
32,
44
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
178,
181
]
} |
previous studies suggested that products of a 12-lipoxygenase pathway in the pancreatic islet may promote insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islet",
"pos": [
77,
93
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
106,
113
]
} |
the adenosine triphosphate and 2,3-diphosphoglycerate levels of the thawed rbcs were within an acceptable range ( mean 3.4 +/- 0.2 mumol/g hb and 18.0 +/- 0.8 mumol/g hb , respectively ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbcs",
"pos": [
75,
79
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
167,
169
]
} |
they also showed weak staining with a heterologous antiserum against t-cells as well as with a monoclonal antibody ( okt11 ) with specificity for an epitope associated with the srbc-receptor , but failed to react with other t-lineage-restricted monoclonal antibodies . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-cells",
"pos": [
69,
76
]
} | {
"id": "C0108773",
"name": "srbc-receptor",
"pos": [
177,
190
]
} |
the erythrocyte dose of alkylating agent , calculated from the extent of haemoglobin alkylation , is in some cases related to liver and extra-hepatic dna doses ; | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
4,
15
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
73,
84
]
} |
effect of short photoperiod on hypothalamic methionine-enkephalin and lhrh content and serum beta-endorphin-like immunoreactivity ( beta-end li ) levels in golden hamsters . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
31,
43
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
70,
74
]
} |
melatonin acts on specific receptor sites at hypothalamic and perhaps extrahypothalamic sites to affect lhrh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
45,
57
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
104,
108
]
} |
basement membrane reactivity of antisera to type iv collagen and sera from patients with bullous pemphigoid and epidermolysis bullosa acquisita . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
0,
17
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
44,
60
]
} |
although the t cell repertoire is mainly determined , in a single individual , by the alleles expressed at the mhc locus , one can postulate that it could also be influenced by the existence of alleles of the germ line gene ( s ) encoding the t cell receptor . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
13,
19
]
} | {
"id": "C0034790",
"name": "t cell",
"pos": [
243,
249
]
} |
age-dependent rbc changes observed were decreases in pcv and hemoglobin ( hb ) and mean cell hb concentrations in neonatal kittens and a subsequent increase in pcv , hb concentration , and rbc count in juvenile kittens . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
14,
17
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
61,
71
]
} |
here michael hoffmann discusses the possibility that , instead of restricting t-cell activity , recognition of mhc-encoded self-antigen by the t-cell receptor is actually the consequential event in t-cell ffector function and that foreign antigen plays an accessory role . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-cell",
"pos": [
78,
84
]
} | {
"id": "C0034790",
"name": "t-cell receptor",
"pos": [
143,
158
]
} |
the endocrine role of the thymus and its hormone , thymosin , in the regulation of the growth and maturation of host immunological competence . | tissue_is_expression_site_of_gene_product | {
"id": "C0040113",
"name": "thymus",
"pos": [
26,
32
]
} | {
"id": "C0040106",
"name": "thymosin",
"pos": [
51,
59
]
} |
cell bodies of small to moderate-sized neurons in the female rat hypothalamus were stained specifically for somatostatin ( srif ) by means of the unlabeled antibody-peroxidase-antiperoxidase immunocytochemical method . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
65,
77
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
123,
127
]
} |
bovine cardiac 3':5'-cyclic amp-dependent protein kinase catalyses the phosphorylation of cardiac troponin i 30 times faster than white-skeletal-muscle troponin i . | tissue_is_expression_site_of_gene_product | {
"id": "C0018787",
"name": "cardiac",
"pos": [
7,
14
]
} | {
"id": "C1305957",
"name": "cardiac troponin i",
"pos": [
90,
108
]
} |
females of the most susceptible strains ( lh and aug ) were found to have significantly more severe thyroid lesions and higher antibody titres to thyroglobulin than males . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
100,
107
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
146,
159
]
} |
both t-cell and non-t-cell fc receptors were blocked by aggregated mouse igg2 to the same degree . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-cell",
"pos": [
5,
11
]
} | {
"id": "C0034790",
"name": "t-cell",
"pos": [
20,
26
]
} |
differential effects of hypothalamic deafferentation upon luteinizing hormone-releasing hormone in the median eminence and organum vasculosum of the lamina terminalis . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
24,
36
]
} | {
"id": "C0023610",
"name": "luteinizing",
"pos": [
58,
69
]
} |
proceedings : hypothalamic-pituitary relationships in the polycystic ovary syndrome : effect of sex steroids on luteinizing hormone releasing hormone responses . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
14,
26
]
} | {
"id": "C0023610",
"name": "luteinizing hormone releasing hormone",
"pos": [
112,
149
]
} |
it is concluded that stimulation of the sympathetic innervation to the pancreatic islets , at frequencies within thephysiological range , stimulates the release of glucagon and inhibits that of insulin in each of these species . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic",
"pos": [
71,
81
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
194,
201
]
} |
the injection of sera of adult mice or of a 20 % extract of small and large intestine , liver , kidney , spleen , thymus , and lungs of adult mice suppressed the alpha1 fetoprotein production in syngeneic newborn recipients . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
88,
93
]
} | {
"id": "C0002210",
"name": "alpha1 fetoprotein",
"pos": [
162,
180
]
} |
effects of coincubation of the pituitary and hypothalamus of intact and castrate male rats and the influence of lh-rh on pituitary 5 alpha-reductase activity1,2 . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
45,
57
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
112,
117
]
} |
[ study of erythrocyte organic phosphates and the affinity of hemoglobin for oxygen in a hyperbaric atmosphere with slightly hyperoxic helium-oxygen mixture ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
11,
22
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
62,
72
]
} |
sickling , viscosity and gelling properties of the red cells and the hemoglobins of three virginia white-tailed deer homozygous for types ii and iii ( the sickling types ) and v ( the nonsickling type ) , respectively , have been analyzed . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
51,
60
]
} | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
69,
80
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.