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stringlengths 57
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the erythrocyte glutathione peroxidase activities , as mumol of nadph oxidized/g hemoglobin/min , averaged 11.01 in patients and 31.76 in controls ( p less than 0.01 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
4,
15
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
81,
91
]
} |
fluoride had no effect on thyroglobulin content of the thyroid gland or on the degree of iodination of thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid gland",
"pos": [
55,
68
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
103,
116
]
} |
the availability of these peptides , which show a high degree of homology with the physiologic rat hypothalamic grf , offers the unique opportunity to assess somatotrope responsiveness to grf molecules in rats with hypothalamo-pituitary disconnection . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
99,
111
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
188,
191
]
} |
the data suggest that thiourea-containing chemical compounds sensitize pancreatic islets to the insulin-triggering action of glucose . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
71,
88
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
96,
103
]
} |
8-10 days after making various lesions in the rat hypothalamus , the presence of corticotropin releasing factor ( crf ) immunoreactive neural structures was studied in paraffin and vibratome sections with crf immunocytochemistry . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
50,
62
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
205,
208
]
} |
erythrocytes of dorset sheep , an animal model with an erythrocyte glucose-6-phosphate dehydrogenase ( g-6-pd ) deficiency , responded in a dose-dependent manner to the oxidant stress of di- and trichloroacetic acids ( dca and tca ) as measured by increases in methemoglobin ( methb ) and decreases in glutathione ( gsh ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
0,
11
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
261,
274
]
} |
these findings suggest that hypothalamic growth hormone-releasing factor may regulate its own neurosecretion through an `` '' ultrashort-loop '' '' negative feedback mechanism and may have important neurotransmitter and neuromodulatory functions in the brain . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
28,
40
]
} | {
"id": "C0037668",
"name": "growth hormone-releasing factor",
"pos": [
41,
72
]
} |
in spite of the variations in red cell 2,3-dpg , hemoglobin-oxygen affinity expressed as p50 at actual ph remained unchanged during pregnancy and post partum . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
30,
38
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
49,
59
]
} |
in spite of the increase in red cell 2,3-diphosphoglycerate content and the decrease in hemoglobin a1c , factors known to reduce hemoglobin-oxygen affinity , the position of the oxyhemoglobin dissociation curve remained unchanged during diabetic pregnancy : p50 at actual ph in the first trimester , was 26.0 mmhg ; | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
28,
36
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
181,
191
]
} |
in spite of the increase in red cell 2,3-diphosphoglycerate content and the decrease in hemoglobin a1c , factors known to reduce hemoglobin-oxygen affinity , the position of the oxyhemoglobin dissociation curve remained unchanged during diabetic pregnancy : p50 at actual ph in the first trimester , was 26.0 mmhg ; | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
28,
36
]
} | {
"id": "C0030069",
"name": "oxyhemoglobin",
"pos": [
178,
191
]
} |
immunohistochemical and metabolic labelling studies on the established lines in vivo and in vitro revealed a consistent pattern with respect to their biosynthesis of the basement membrane components laminin , entactin , and type iv collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement",
"pos": [
170,
178
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
224,
240
]
} |
iron status was investigated with serum ferritin , erythrocyte protoporphyrin , mean cell volume and mean cell hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
51,
62
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
111,
121
]
} |
in hydatidiform mole , which still retains placental villous morphology , the hpl gene and hcg alpha and hcg beta genes are expressed but are poorly localized because of the admixture of cyto- and syncytiotrophoblasts . | tissue_is_expression_site_of_gene_product | {
"id": "C0032043",
"name": "placental",
"pos": [
43,
52
]
} | {
"id": "C0106132",
"name": "hcg beta",
"pos": [
105,
113
]
} |
by contrast , choriocarcinoma , which is devoid of placental villous pattern but in which the cyto- and syncytiotrophoblast-like components are distinguishable , expresses hcg alpha and hcg beta in the syncytial-like areas but little , if any , hpl . | tissue_is_expression_site_of_gene_product | {
"id": "C0032043",
"name": "placental",
"pos": [
51,
60
]
} | {
"id": "C0106132",
"name": "hcg beta",
"pos": [
186,
194
]
} |
preparation of low-affinity red cells with dimethylsulfoxide-mediated inositol hexaphosphate incorporation : hemoglobin and atp recovery using a continuous-flow method . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
28,
37
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
109,
119
]
} |
incorporation of ihp into red cells decreases oxygen affinity as a result of the binding of this compound to the 2,3-dpg site of hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
26,
35
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
129,
139
]
} |
the distribution of na+ and k+ around the rbc membrane was considered to contribute to increasing the adsorption of albumin on the outer surface and to restricting the deposition of hemoglobin on the inner surface with a consequent positive effect on maintaining the stiffness and flexibility of the membrane . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
42,
45
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
182,
192
]
} |
rat fetal hypothalamic cells were kept in culture for two weeks and basal and stimulated gnrh release was measured by highly sensitive ria . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
10,
22
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
89,
93
]
} |
these intact hypothalamic cells did not degrade gnrh during 4 hours of incubation , but a 50 % degradation occurred after 24 hours incubation followed by hplc using specifically tritium labeled gnrh or ria . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
13,
25
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
194,
198
]
} |
our results suggest that intact hypothalamic cells under physiological circumstances do not degrade extracellular gnrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
32,
44
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
114,
118
]
} |
desmoplastic trichoepithelioma : clinico-pathological features and immunohistochemical study of the basement membrane proteins , laminin and type iv collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
100,
117
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
141,
148
]
} |
formation of a stable complex of thrombin and the secreted platelet protein glycoprotein g ( thrombin-sensitive protein , thrombospondin ) by thiol-disulfide exchange . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
59,
67
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
122,
136
]
} |
the tumor was determined not to be of prostatic origin clinically and by absence of immunoperoxidase staining for prostatic acid phosphatase , prostate specific antigen , and carcinoembryonic antigen . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
38,
47
]
} | {
"id": "C0138741",
"name": "prostate specific",
"pos": [
143,
160
]
} |
this strongly suggests that in these four subjects , the discrepancy in gh responses to hp grf1-44 , itt and to arginine was a result of radiation-induced hypothalamic damage leading to a deficiency of endogenous grf . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
155,
167
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
213,
216
]
} |
to accomplish the foregoing , radiofrequency lesions were placed in the region of the arcuate nucleus to abolish endogenous hypothalamic gnrh secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
124,
136
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
137,
141
]
} |
bilateral orchidectomy in this experimental paradigm elicited only small increments in lh pulse amplitude and mean plasma lh concentration , a response in striking contrast to the dramatic postcastration lh hypersecretion observed in animals with intact hypothalami that respond to the opening of the negative feedback loop with an apparent acceleration in the endogenous frequency of intermittent gnrh secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
254,
265
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
398,
402
]
} |
since hypophysectomy and gh deficiency are associated with decreases in hypothalamic content and release of srif , it was of interest to determine whether these hormonal alterations also affect peripheral tissue levels of srif . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
72,
84
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
222,
226
]
} |
pancreatic , gastric , and hypothalamic srif levels were measured by ria and expressed as nanograms per mg protein or nanograms per organ . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
27,
39
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
40,
44
]
} |
decreased levels of hypothalamic srif were observed in hypox animals at all time periods after surgery . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
20,
32
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
33,
37
]
} |
therefore , in the rhesus monkey , p seems to activate neural substrates in the ventral hypothalamus to promote the release of lhrh and , subsequently , lh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
88,
100
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
127,
131
]
} |
in untreated cultures a few , small plaques formed , but in the presence of hypothalamic gnrh ( 10 ( -7 ) m , a maximally stimulating dose ) a 10-fold increase occurred in their number and size . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
76,
88
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
89,
93
]
} |
macrophages ( m phi ) from the genetically defective mouse strains c3h/hej , a/j and p/j were unable to develop high levels of antitumor activities when stimulated either with immune recombinant interferon gamma ( ifn-gamma ) or with nonimmune ifn-alpha and ifn-beta , as compared to m phi or normal c3h/hen mice . | tissue_is_expression_site_of_gene_product | {
"id": "C0024432",
"name": "macrophages",
"pos": [
0,
11
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
258,
266
]
} |
the lymphocytes generated during this culture interval are washed , divided into replicate aliquots , and then further cultured ( with and without additional klh ) to see if the original phtl has generated cells which are capable of further lymphokine production . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
4,
15
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
241,
251
]
} |
at the lower temperature the mlr could be enhanced by polyethylene glycol ( peg ) for spleen cells and by con a induced lymphokines for peripheral blood cells ( pbl ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "mlr",
"pos": [
29,
32
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
120,
131
]
} |
the response was assessed by measuring both [ 3h ] thymidine incorporation and the ability of lymphocytes to produce immunoglobulins and lymphokine activity . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
94,
105
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
137,
147
]
} |
introduction of a single methyl group onto the carbon-carbon double bond of the fumaryl moiety decreases the lability of the ester 10-fold , due to steric effects , and allows the reagent to be taken up by the red cell and modify intracellular hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
210,
218
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
244,
254
]
} |
in this study we have demonstrated that purified human platelet tsp formed a complex with purified human plasminogen ( plg ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
55,
63
]
} | {
"id": "C0076560",
"name": "tsp",
"pos": [
64,
67
]
} |
a series of a-ring heterocyclic steroids has been prepared and tested for inhibition of rat prostatic steroid 5 alpha-reductase in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
92,
101
]
} | {
"id": "C0039602",
"name": "steroid 5 alpha-reductase",
"pos": [
102,
127
]
} |
changes in response to therapy in 15 patients with malignant liver disease were monitored by serial measurements with demonstrable changes in volume which , in those with alpha-fetoprotein tumours , were in parallel with changes in serum alpha-fetoprotein levels . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
61,
66
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
238,
255
]
} |
a strategy for rapid cloning and identification of cdna clones was employed to obtain fragments of the gene for human fibroblast ( beta ) interferon . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
118,
128
]
} | {
"id": "C0015980",
"name": "beta",
"pos": [
131,
135
]
} |
this electrophysiologic manifestation of the hypothalamic 'pulse generator ' which governs the secretion of hypothalamic luteinizing hormone releasing hormone provides , for the first time , direct access to the central component of the neuroendocrine control system which regulates reproductive processes in this higher primate . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
45,
57
]
} | {
"id": "C0023610",
"name": "luteinizing hormone",
"pos": [
121,
140
]
} |
a ligand-specific action of chelated copper on hypothalamic neurons : stimulation of the release of luteinizing hormone-releasing hormone from median eminence explants . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
47,
59
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
100,
137
]
} |
in this study , we wished to ascertain if chelated copper acts on hypothalamic neurons to stimulate lhrh release and , if so , what is the ligand specificity of this interaction . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
66,
78
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
100,
104
]
} |
based on these results and those of others indicating that the concentration of copper in hypothalamic axonal terminals is 1-2 orders of magnitude greater than plasma , we propose that copper released in the vicinity of the lhrh neurons interacts with specific sites on the lhrh axonal terminals , which leads to release of the peptide . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
90,
102
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
274,
278
]
} |
male rats to which oestradiol benzoate was administered intramuscularly twice a week for three weeks in 1 mg doses as an aqueous microcrystal suspension showed an increase in adenohypophyseal weight , in the number of lactotropic cells in the adenohypophysis ( demonstrated by immunohistochemical detection of prolactin ) and in polyphenol oxidase ( ceruloplasmin ) activity in the blood and hypothalamus . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "adenohypophysis",
"pos": [
243,
258
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
310,
319
]
} |
purified platelet thrombospondin ( ts ) was subjected to proteolysis with a number of proteases including factors ixa , xa , thrombin , elastase , trypsin , and chymotrypsin . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
9,
17
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
18,
32
]
} |
old rbcs had reduced mean corpuscular hemoglobin volume , increased mean corpuscular hemoglobin concentration , and reduced sialic acid . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbcs",
"pos": [
4,
8
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
85,
95
]
} |
it is shown that igg typical of the normal growth appears in blood of rats with the regenerating liver and in pregnant ones and its capacity to form complexes with alpha-globulins insoluble in acid medium , isoelectric point and molecular mass are similar to these features in igg typical of the malignant growth . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
97,
102
]
} | {
"id": "C0002211",
"name": "alpha-globulins",
"pos": [
164,
179
]
} |
thus the serum reveals e rosette-forming t cells and their subpopulations , perhaps by binding to the srbc receptor . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
41,
48
]
} | {
"id": "C0108773",
"name": "srbc receptor",
"pos": [
102,
115
]
} |
the mechanisms for the changes are at present only speculative , but solvent induced changes in muscle cell membranes with subsequent enzyme leakage seem the most reasonable explanation for the increase in s-ck concentration , while an effect on the hypothalamic fsh releasing hormone may explain the decrease in s-fsh concentration . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
250,
262
]
} | {
"id": "C0023610",
"name": "fsh releasing hormone",
"pos": [
263,
284
]
} |
the prostatic-type columnar cells contained foamy , faintly eosinophilic cytoplasm , which stained strongly for prostate specific antigen and prostatic acid phosphatase . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
4,
13
]
} | {
"id": "C0138741",
"name": "prostate specific antigen",
"pos": [
112,
137
]
} |
eosinophilic ( prolactin-somatotrophic ) adenohypophyseal hyperplasia which was much higher than that expected in pregnancy evidenced the role of both prolactin and somatotrophic hormone in the pathogenesis of the mamma giantism . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "adenohypophyseal",
"pos": [
41,
57
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
151,
160
]
} |
the experiment has been done on 63 patients affected by allergic contact dermatitis and sensitized to potassium dichromate and on 76 non allergic subjects to control : if leukocytes ( separated in emagel ) , mononuclear cells ( separated in lymphoprep ) and t-lymphocytes ( separated through rosettes with neuraminidase ) bind the 51cr , if this binding depends on the valence ( cr3+ and cr6+ ) and on the type of cells and if it is conditioned by the hypersensitivity . | tissue_is_expression_site_of_gene_product | {
"id": "C0023516",
"name": "leukocytes",
"pos": [
171,
181
]
} | {
"id": "C0079785",
"name": "cr3",
"pos": [
379,
382
]
} |
the platelet protein thrombospondin ( tsp ) which is secreted from alpha-granules upon platelet activation agglutinates trypsinized , glutaraldehyde-fixed human erythrocytes . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
4,
12
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
21,
35
]
} |
these data show that changes of the total phospholipid content of pancreatic islets are unrelated to the islet insulin content and presumably also to the content of secretory granules . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
66,
83
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
111,
118
]
} |
these results indicate that exposure to exogenous estrogen or t prior to puberty precipitates the decline in estrous cyclicity associated with the loss of gonadotropin surge response , presumably due to an alteration in hypothalamic gnrh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
220,
232
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
233,
237
]
} |
autoradiographic studies after subcutaneous injection of [ 3h ] estradiol to the fetus showed the nuclear localization of radioactivity in the hypothalamus to be in the neurons of the preoptic area and the nucleus arcuatus where gonadotropin-releasing hormone was also present . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
143,
155
]
} | {
"id": "C0023610",
"name": "gonadotropin-releasing hormone",
"pos": [
229,
259
]
} |
a radioimmunoassay was developed for the detection of 7 s collagen , a basement membrane component derived from type iv collagen , in sera of patients . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement",
"pos": [
71,
79
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
112,
128
]
} |
radioimmune assays of cellular fractions or rat islet-cell preparations showed that the granule-rich fraction containing large amounts of insulin was also rich in sod . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet-cell",
"pos": [
48,
58
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
138,
145
]
} |
these are : adenilate-kinase ( ak ) , diaphorase nad x h ( dia ) , glyoxalase-1 ( glo-1 ) , glucose-6-phosphate dehydrogenase ( 6gpt ) , glutamatpyruvate transaminase ( gpt ) , glutamicoxalate transaminase ( got ) , carbonic anhydrase-1 ( ca-1 ) , catalase ( ct ) , acid phosphatase ( acp ) , lactate dehydrogenase ( loci ldh-a and ldh-b ) , leucine aminopeptidase ( lap ) , malatedehydrogenase ( mdh ) , purine nucleoside phosphorylase ( pnp ) , superoxide dismutase ( sod ) , 6-phosphogluconate dehydrogenase ( pgd ) , phosphoglucomutase ( loci pgm1 and pgm2 ) , cholinesterase ( loci c1 -- c5 ) , alkaline phosphatase ( pp ) , esterase d ( esd ) , red cell esterase ( est ) - 4 loci , albumin ( alb ) , haptoglobin ( hp ) , hemoglobine ( hb a and b ) , group-specific component ( gc ) , transferrin ( tf ) , ceruloplasmin ( cp ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
651,
659
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
741,
743
]
} |
recent studies using cloned antigen-specific t lymphocytes and monoclonal antibodies directed at their various surface glycoprotein components have led to identification of the human t cell antigen receptor as a surface complex comprised of a clonotypic 90kd ti heterodimer and the monomorphic 20/25kd t3 molecules . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
45,
58
]
} | {
"id": "C0034790",
"name": "t cell antigen receptor",
"pos": [
183,
206
]
} |
blood lymphocytes from 8 patients with common variable immunodeficiency ( cvid ) , 5 patients with signs of polyclonal activation of the immune system ( 1 sle , 3 ailap , 1 nhl ) and 6 patients with various granulomatous diseases were examined for their capacity to produce lymphokines in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "blood lymphocytes",
"pos": [
0,
17
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
274,
285
]
} |
notably lymphocytes from the three patients with angioimmunoblastic lymphadenopathy ( ailap ) failed to produce significant amounts of lymphokines . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
8,
19
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
135,
146
]
} |
the results are compared with other lymphocyte parameters and are discussed in view of recent reports in the literature on lymphokine production in various diseases . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
36,
46
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
123,
133
]
} |
activation of probable proinsulin-converting enzymes in pancreatic islets : its correlationship with rate of insulin biosynthesis . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
56,
73
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
109,
116
]
} |
hyperbaric nitrogen at a pressure of 100 atmospheres increases significantly the affinity of erythrocytic hemoglobin for oxygen . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
93,
105
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
106,
116
]
} |
an immunocytochemical method for fixed and paraffin-embedded human breast biopsies is reported for the detection of myoepithelial and epithelial cells using antibodies to myosin and keratin , respectively , and of basement membranes using antibodies to laminin and type iv collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membranes",
"pos": [
214,
232
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
265,
281
]
} |
basement membrane proteins , laminin , and type iv collagen are present in normal breast , benign breast disease , and grade i infiltrating ductal carcinomas but are absent in carcinomas of grades ii and iii . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement",
"pos": [
0,
8
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
43,
59
]
} |
these experiments demonstrate that 1 ) hypothalamic lhrh release in the ovx ewe occurs in discrete pulses , with a mean interpulse interval of 38.7 +/- 1.5 min , 2 ) lh pulses invariably are preceded or accompanied by lhrh pulses , and 3 ) lh pulse amplitude is highly correlated with lhrh pulse amplitude . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
39,
51
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
285,
289
]
} |
thyroids of control animals not injected with ki were hyperplastic , the tissue showed microfollicles devoid of colloid , thyroglobulin was poorly iodinated , and thyroid peroxidase activity was increased . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroids",
"pos": [
0,
8
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
122,
135
]
} |
within 4 h after ki injections , there was 1 ) a decrease in thyroid weight , 2 ) expansion of the follicular lumens of the hyperplastic in thyroid tissue and accumulation of colloid , 3 ) an increase in the thyroglobulin iodine concentration , and 4 ) a decrease in the thyroid peroxidase activity . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
61,
68
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
208,
221
]
} |
the ability of dispersed islet cells in a perifusion system to secret glucagon and insulin in response to physiologic stimuli was investigated . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cells",
"pos": [
25,
36
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
83,
90
]
} |
dispersed islet cell preparations did not augment insulin secretion in response to glucose but did secrete more insulin in response to arginine . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cell",
"pos": [
10,
20
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
112,
119
]
} |
this reaction revealed type iv collagen as a regular component of basement membranes in nonneoplastic tumor capillaries , but it was equally able to localize collagen type iv between single tumor cells in capillary-free areas . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membranes",
"pos": [
66,
84
]
} | {
"id": "C0009333",
"name": "collagen type iv",
"pos": [
158,
174
]
} |
thus , cultured baes produce multiple , immunologically distinct forms of pa which differ in size , charge , and sensitivity to dfp . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "baes",
"pos": [
16,
20
]
} | {
"id": "C0032144",
"name": "pa",
"pos": [
74,
76
]
} |
female rats were ovariectomized and treated with estradiol benzoate or implanted with estradiol capsules prior to sacrifice in order to minimize to variations in lh and ultimately to maximize hypothalamic lhrh content . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
192,
204
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
205,
209
]
} |
the provisional matrix lacked two major components of normal basement membrane , laminin and type iv collagen , which can mediate tenacious epithelial attachment to plastic in vitro and may limit epidermal cell migration in vivo . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
61,
78
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
93,
109
]
} |
the influence of catecholamines ( ca ) on hypothalamic somatostatin ( hpt-srif ) was investigated in rats by using several drugs which interfere with brain ca metabolism . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
42,
54
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
74,
78
]
} |
stress or other adenohypophyseal mechanisms involving acth , prolactin or gh do not explain the analgesia induced by non-painful , low-frequency tens . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "adenohypophyseal",
"pos": [
16,
32
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
61,
70
]
} |
it had been reported that immunological neutralization of the hypothalamic luteinizing hormone-releasing hormone ( lh-rh ) can be achieved by injection of the synthetic hormone , a decapeptide , linked to a carrier and administered with freund 's complete adjuvant . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
62,
74
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
75,
112
]
} |
liver fat accumulation was associated with the rises in serum aminotransferase activities and with the lack of or a poor rise in serum prothrombin and proconvertin . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
0,
5
]
} | {
"id": "C0015502",
"name": "proconvertin",
"pos": [
151,
163
]
} |
monoclonal antibodies specific for rat hypothalamic growth hormone-releasing factor ( rgrf ) have been produced by in vitro immunization of mouse spleen cells with less than 1 nanomole of rgrf in a partially purified preparation . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
39,
51
]
} | {
"id": "C0037668",
"name": "growth hormone-releasing",
"pos": [
52,
76
]
} |
in 20 patients with congenital brain disorders , the influence of the cns maldevelopment on the neuroendocrine system was investigated by assessment of the hypothalamic-pituitary function through measurements of the secretory reserve of pituitary hormones ( gh , prl , tsh , lh and fsh ) in response to injections of insulin , trh and lh-rh , and of the secretion of sleep-dependent pituitary hormones with polygraphic recording . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
156,
168
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
335,
340
]
} |
we have studied neutralization of the antiviral activity of human fibroblast ( ifn-beta ) and immune interferon ( ifn-gamma ) by incubation with glycolipids ( including the gangliosides gm1 , gm2 and gm3 , as well as various other glycolipids ) and with the sialoglycoprotein , glycophorin . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
66,
76
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
79,
87
]
} |
red cell osmotic hemolysis has traditionally been defined by the loss of hemoglobin , in response to reduced osmotic pressure , as measured spectroscopically . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
0,
8
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
73,
83
]
} |
continuous feeding of alpha-naphthylisothiocyanate to young male sprague-dawley rats was shown to produce a concentration-dependent increase in the number of hepatic ductular cells and a concentration- and time-dependent elevation of serum and liver gamma-glutamyl transpeptidase and alpha-fetoprotein . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
244,
249
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
284,
301
]
} |
in liver , the increased gamma-glutamyltranspeptidase and alpha-fetoprotein were predominantly confined to the proliferative ductular cell population . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
3,
8
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
58,
75
]
} |
inhibition of the pulsatile secretion of growth hormone by monoclonal antibodies to the hypothalamic growth hormone releasing factor ( grf ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
88,
100
]
} | {
"id": "C0037668",
"name": "growth hormone releasing factor",
"pos": [
101,
132
]
} |
[ immunofluorescence study of the prenatal differentiation of hypothalamic cells producing lh-rf and of the maturation of neurosecretory preoptico-infundibular pathway in the guinea pig ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
62,
74
]
} | {
"id": "C0023610",
"name": "lh-rf",
"pos": [
91,
96
]
} |
the complex nature of these results is interpreted in the light of additional data which show ( i ) that the thyroid membrane recognizes asialothyroglobulin and ( ii ) that at ph 5.0 and 37 degrees c a membrane-associated neuraminidase is activated which removes sialic acid from thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
109,
116
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
280,
293
]
} |
moreover , the binding of labeled growth hormone to membrane particles derived from liver of several species was also inhibited by the antisera , thus suggesting that immunological determinants of the growth hormone receptor of several species are similar . gamma-globulin fractions derived from the antisera were responsible for the inhibition . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
84,
89
]
} | {
"id": "C0017007",
"name": "gamma-globulin",
"pos": [
258,
272
]
} |
treatment of human diploid fibroblasts with fibroblast interferon for 8 hr inhibited replication of vesicular stomatitis virus . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
27,
38
]
} | {
"id": "C0015980",
"name": "fibroblast interferon",
"pos": [
44,
65
]
} |
these results indicate that hypothalamic neurons contain small amounts of lhrh and retain the ability to take up and metabolize progesterone , 5 alpha-dihydroprogesterone and 17 beta-estradiol . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
28,
40
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
74,
78
]
} |
following dexamethasone administration , the lh and fsh response to clomiphene citrate , which competes for gonadal steroid receptor binding sites in the hypothalamus , resulting in increased release of lhrh , was blunted in the 10 women studied . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
154,
166
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
203,
207
]
} |
the adenylate cyclase-cyclic amp system in islets of langerhans and its role in the control of insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
43,
63
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
95,
102
]
} |
to investigate the latter suggestion and to examine the possible sites of hypothalamic peptidases inactivating lh-rh , d-ser ( tbu ) 6-ea10-lh-rh and d-leu6-ea10-lh-rh , which are known to have considerably greater activity than lh-rh , were incubated with a hypothalamic supernatant fraction containing active peptidases degrading lh-rh , and their gonadotrophin-releasing ability after incubation with the enzymes was tested in normal , adult male rats ; | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
74,
86
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
332,
337
]
} |
from a comparison of the relative losses of biological activity , both the lh-rh analogues treated proved to be more resistant to the hypothalamic peptidases than lh-rh itself ; | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
134,
146
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
163,
168
]
} |
pig thyroid slices were incubated with na131i and the 17 -- 19s 131i-labeled thyroglobulin isolated was subjected to dissociation with 0.3 mm sodium dodecyl sulphate sds ) on sucrose density gradient centrifugation and to iodoamino acid analysis . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
4,
11
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
77,
90
]
} |
these results suggest that , in the incubation of thyroid slices , iodine atoms are preferentially incorporated into newly synthesized , less iodinated thyroglobulin , rather than preformed thyroglobulin , and that the iodination occurs , at least to a certain degree , in apical vesicles before the thyroglobulin is secreted into the colloid lumen . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
50,
57
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
300,
313
]
} |
the results are readily compatible with the hypothesis that is proposed that lia is in large part of the consequence of the release of soluble mediators or lymphokines that may act either directly on endothelial cells or indirectly by activating macrophages , which in turn generate the vascular reaction . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lia",
"pos": [
77,
80
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
156,
167
]
} |
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