text
stringlengths 57
1.72k
| relation
stringclasses 125
values | h
dict | t
dict |
|---|---|---|---|
the pancreatic islets of leptocephalic larvae exhibited a strong reaction for srif , a weak reaction for glu , and none at all for ins , met-enk , or 5-ht . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic",
"pos": [
4,
14
]
} | {
"id": "C0021641",
"name": "ins",
"pos": [
131,
134
]
} |
an igm monoclonal antibody directed against the t-cell e-rosette receptor was obtained by preparing a hybridoma against cells of a human t-cell leukemia line , hpb-all . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-cell",
"pos": [
48,
54
]
} | {
"id": "C0108773",
"name": "e-rosette receptor",
"pos": [
55,
73
]
} |
tumor-promoting phorbol esters and cell proliferation stimulate secretion of basement membrane ( type iv ) collagen-degrading metalloproteinase by human fibroblasts . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
77,
94
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
97,
104
]
} |
moreover , these studies extend the conclusion ( weber , h. , engel , j. , wiedemann , h. , glanville , r. , and timpl , r. ( 1984 ) eur . j. biochem . 139 , 401-410 ) about a tumor basement membrane , to an authentic physiological membrane , that the globular domain is a major cross-linking site in the type iv collagen matrix . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
182,
199
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
305,
321
]
} |
since the pulsatile frequency of lh is governed by hypothalamic influences , these findings provide compelling evidence for a hypothalamic site of action for cc , probably by inducing an increase in the frequency of gnrh secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
51,
63
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
216,
220
]
} |
recent studies using cloned antigen-specific t lymphocytes and monoclonal antibodies directed at their various surface glycoprotein components have led to the identification of the human t-cell antigen receptor as a surface complex comprised of a clonotypic 90-kd ti heterodimer and the invariant 20- and 25-kd t3 molecules . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
45,
58
]
} | {
"id": "C0034790",
"name": "t-cell antigen receptor",
"pos": [
187,
210
]
} |
in this study we have demonstrated that purified human platelet tsp formed a trimolecular complex with human plg and hrgp . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
55,
63
]
} | {
"id": "C0076560",
"name": "tsp",
"pos": [
64,
67
]
} |
we conclude that the lymphocyte unresponsiveness characterizing patients with q fever endocarditis is modulated in part by an antigen-specific t suppressor cell which secretes a lymphokine to stimulate pge2 production by adherent cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
21,
31
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
178,
188
]
} |
examples would include thymosin alpha 1 and beta 4 , lymphocyte-derived acth , tsh , and beta-endorphin , interleukin 1 , interferon as well as certain other lymphokines and cytokines . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
53,
63
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
158,
169
]
} |
in the hypothalamus , the somatostatin perikarya are located in and near the magnocellular preoptic nucleus and also in the pars ventralis of the tuber cinereum . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
7,
19
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
26,
38
]
} |
previous investigations have shown that hypothalamic luteinizing hormone releasing hormone ( lhrh ) is localized within a subcellular fraction eqivalent or similar to the synaptosome or nerve ending particle . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
40,
52
]
} | {
"id": "C0023610",
"name": "luteinizing hormone",
"pos": [
53,
72
]
} |
these observations led us to conclude that estrogens can alter the physical properties of the hypothalamic lhrh-containing particles or the storage form of the peptide within those particles so that it is less easily released . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
94,
106
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
107,
111
]
} |
this phenomenon may represent one aspect of the regulatory effects of estrogens on hypothalamic lhrh secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
83,
95
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
96,
100
]
} |
there is evidence for a neural link between the adrenal and hypothalamus that may mediate increased corticotropin-releasing factor and acth secretion within seconds after bilateral adrenalectomy . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
60,
72
]
} | {
"id": "C0010132",
"name": "corticotropin-releasing factor",
"pos": [
100,
130
]
} |
distribution of basement membrane proteins in normal and fibrotic human liver : collagen type iv , laminin , and fibronectin . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
16,
33
]
} | {
"id": "C0009333",
"name": "collagen type iv",
"pos": [
80,
96
]
} |
effects of parturition and suckling on concentrations of pituitary gonadotropins , hypothalamic gnrh and pituitary responsiveness to gnrh in ewes . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
83,
95
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
133,
137
]
} |
the nonspecific mitogen concanavalin a elicited normal lymphokine responses in 9 of 10 elderly subjects , indicating that lymphocytes from the elderly have a normal capacity for lymphokine production when activated by a sufficient stimulus . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
122,
133
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
178,
188
]
} |
gel filtration of human rbc lysate incubated with labeled t4 or t3 revealed co-elution of a major iodothyronine-binding fraction ( r-2 ) and hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
24,
27
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
141,
151
]
} |
thus a major fraction of thyroid hormone binding in human rbc cytoplasm is accounted for by an interaction with hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
58,
61
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
112,
122
]
} |
however , liver cytosolic alpha-fetoprotein was markedly increased after ethanol consumption , suggesting the presence of impaired secretion or mobilization from the liver cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
10,
15
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
26,
43
]
} |
red cells exposed to concentrations of t-butyl hydroperoxide of less than 750 microm for 15 min exhibited significant decreases in cellular and membrane deformability , increases in membrane-associated protein cross-linking , osmotic fragility and the viscosity of the intracellular hemoglobin solution . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
0,
9
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
283,
293
]
} |
instrumental in the process of maturation of estrogen positive feedback are an enhanced capability of the hypothalamus to release lhrh ( luteinizing hormone-releasing hormone ) and an increase in responsiveness of the ovaries to gonadotropins . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
106,
118
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
137,
174
]
} |
high prolactin levels stimulate hypothalamic dopamine ( da ) turnover , which may actively inhibit hypothalamic luteinizing hormone-releasing hormone ( lhrh ) release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
32,
44
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
112,
149
]
} |
no alteration in hypothalamic content of trh and lhrh was observed after chronic trh treatment . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
17,
29
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
49,
53
]
} |
quick formation of ferrihemoglobin by i.v . injection of 4-dimethylaminophenol after plasma cyanide had risen to or above 40 micron decreased the cyanide concentration in plasma and restored respiration , while cyanide was accumulated in red cells by formation of ferrihemoglobin cyanide . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
238,
247
]
} | {
"id": "C0025635",
"name": "ferrihemoglobin",
"pos": [
264,
279
]
} |
gonadal function in both sexes is under the synergistic control of the pituitary gonadotrophins , follicle stimulating hormone ( fsh ) and luteinising hormone ( lh ) which are in turn influenced both by the hypothalamus ( via the gonadotrophin releasing hormone ) and by feedback signals from the gonads . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
207,
219
]
} | {
"id": "C0023610",
"name": "gonadotrophin",
"pos": [
230,
243
]
} |
the ectopic production of the glycopeptide hormone human placental choriogonadotropin by hela ( 65 ) cells was measured by radioimmunoassay with antiserum against the beta-subunit of choriogonadotropin and with the ( 125 ) i-labelled beta-subunit as a tracer antigen . | tissue_is_expression_site_of_gene_product | {
"id": "C0032043",
"name": "placental",
"pos": [
57,
66
]
} | {
"id": "C0106132",
"name": "beta-subunit",
"pos": [
234,
246
]
} |
effects of morphine and naloxone on serum lh , fsh and prolactin levels and on hypothalamic content of lh-rf in proestrous rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
79,
91
]
} | {
"id": "C0023610",
"name": "lh-rf",
"pos": [
103,
108
]
} |
the hypothalamic lh-rf content of proestrous rats at 1800 hr ( during the proestrus surge ) was not significantly different from that at 1400 hr ( before the surge ) and was not affected by pretreatment with morphine or naloxone . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
4,
16
]
} | {
"id": "C0023610",
"name": "lh-rf",
"pos": [
17,
22
]
} |
effect of neonatal castration on the content of hypothalamic lhrh , pituitary lh and plasma lh in developing male rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
48,
60
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
61,
65
]
} |
the content of hypothalamic lhrh and concentration of lh in pituitary and plasma were measured on day 5 , 7 , 10 , 14 , 17 , 22 , 25 , 30 , 45 , 52 and 60 in male rats which were bilaterally castrated on day 2 . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
15,
27
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
28,
32
]
} |
the content of hypothalamic lhrh declined initially following castration , but from day 17 onwards significantly higher levels of hypothalamic lhrh were maintained in neonatally castrated rats than in intact control . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
15,
27
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
143,
147
]
} |
initial decline in the content of hypothalamic lhrh may be because of stimulation of release of lhrh which exceeds maximal rate of synthesis and subsequent increase in the content of hypothalamic lhrh may be due to enhanced lhrh synthesis as a result of castration . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
34,
46
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
224,
228
]
} |
isolated pancreatic islets of these two groups of sand rats were incubated with [ 3h ] -leucine to study the incorporation of this amino acid into proinsulin and insulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
9,
26
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
162,
169
]
} |
since 19-s and 27-s thyroid iodoproteins are formed of two and four probably identical chains , they must be termed 19-s and 27-s thyroglobulins or alternatively thyroglobulin dimer and tetramer , respectively . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
20,
27
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
162,
175
]
} |
isolated pancreatic islets obtained from spontaneously diabetic mice were recently shown to have a considerably reduced rate of insulin biosynthesis in response to glucose . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
9,
26
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
128,
135
]
} |
identification of a subpopulation of lymphocytes producing lymphokines was attempted by fractionating the lymph node cells from guinea pigs immune to dnp-bsa by velocity sedimentation at 1 x g . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
37,
48
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
59,
70
]
} |
cns-hypothalamic dopamine , norepinephrine , prostaglandins as well as lh-rh systems are involved in the negative and positive feedback effect of oestradiol . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
4,
16
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
71,
76
]
} |
we conclude : 1 ) the ovary is not highly and rapidly responsive to transient elevations of endogenous gonadotropin , and 2 ) adrenal androgens may to some extent modulate the maturation of the hypothalamic-pituitary-gonadal system , at least as reflected by the pituitary response to exogenous gn-rh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
194,
206
]
} | {
"id": "C0023610",
"name": "gn-rh",
"pos": [
295,
300
]
} |
in vitro assessments were carried out to study some biological aspects of immune lymphocytes producing a new lymphokine , called by the authors toxoplasma growth inhibitory factor ( toxo-gif ) , which inhibits the intracellular multiplication of toxoplasma gondii within nonimmune mouse macrophages . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
81,
92
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
109,
119
]
} |
treatment of splenic lymphocytes with inhibitors of protein synthesis , cycloheximide or puromycin resulted in a remarkable reduction of the ability of sensitized lymphocytes to produce this lymphokine . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
21,
32
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
191,
201
]
} |
electrophysiological studies of rat islet cells in monolayer culture were undertaken to determine the role of transmembranous ionic fluxes in the inhibitory action of somatostatin on insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet cells",
"pos": [
36,
47
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
183,
190
]
} |
the development of the hypothalamo-pituitary axis in the neonatal rat : sexual maturation in male and female rats as assessed by hypothalamic lhrh and pituitary and serum lh and fsh concentrations . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
129,
141
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
142,
146
]
} |
[ behavior of the islands of langerhans of the pancreas in vitro . 3. insulin secretory rate in relation to the survival time and the glucose concentration of the medium ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "of",
"pos": [
11,
13
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
70,
77
]
} |
the responses to moderate exercise of circulating energy fuels and endocrine pancreatic hormones were examined in insulin-dependent diabetics receiving insulin either sc or by continuous iv infusion . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "endocrine",
"pos": [
67,
76
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
152,
159
]
} |
the increased amount of denatured hemoglobin in hb ss red cells may be related to the instability of sickle oxyhemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
54,
63
]
} | {
"id": "C0030069",
"name": "oxyhemoglobin",
"pos": [
108,
121
]
} |
hypothalamic luteinizing hormone releasing factor and corticotrophin releasing activity in relation to pituitary and plasma hormone levels in male and female rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "luteinizing hormone releasing factor",
"pos": [
13,
49
]
} |
a-cell behavior in organ culture of isolated rat islets : secretion and tissue content of glucagon and insulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "cell",
"pos": [
2,
6
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
103,
110
]
} |
successful cultivation of isolated islets of langerhans without attachment : relationship between glucose- and theophylline-induced insulin release and insulin content in rats islets after cultivation . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "of",
"pos": [
23,
25
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
152,
159
]
} |
tetracycline ( 2 and 20 micronm ) inhibited glucose-stimulated insulin secretion from isolated rat islets of langerhans , although it failed to alter tolbutamide-stimulated insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
99,
119
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
173,
180
]
} |
the i-gn-rh-like material apparently has a ( partial ) structure consistent with the 5 leads to 9 amino acid sequence of hypothalamic gn-rh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
121,
133
]
} | {
"id": "C0023610",
"name": "gn-rh",
"pos": [
134,
139
]
} |
the present results indicate that : ( 1 ) disconnexion between the central nervous system and the anterior pituitary gland greatly enhances gh responsiveness while blunting prolactin responsiveness to trh ; | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior pituitary gland",
"pos": [
98,
122
]
} | {
"id": "C0040160",
"name": "trh",
"pos": [
201,
204
]
} |
these results suggest that antigen stimulates specifically sensitized lymphocytes to release an agent ( perhaps a lymphokine ) that activates phagocytic cells to release ep . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
70,
81
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
114,
124
]
} |
time course of effects of morphine on hypothalamic content of lhrh and serum testosterone and lh levels of morphine-tolerant and nontolerant male rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
38,
50
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
62,
66
]
} |
time course of the effects of morphine on the hypothalamic content of lhrh in both nontolerant and morphine-tolerant male rats was investigated in relation to the temporal changes of serum testosterone and lh levels . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
46,
58
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
70,
74
]
} |
the hypothalamic lhrh content of the nontolerant rats was increased 8 hr after the administration of morphine ( 100 mg/kg ) when serum testosterone levels were depressed . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
4,
16
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
17,
21
]
} |
although the hypothalamic lhrh content does not necessarily reflect the release of lhrh , these results are in favour of the hypothesis that the release of hypothalamic lhrh is inhibited by the administration of morphine and is restored by the withdrawal of the narcotic . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
13,
25
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
169,
173
]
} |
the role of sialic acid in the gel-filtration behaviour of sialoglycoproteins was investigated by using the separated isoenzymes of purified human liver alpha-l-fucosidase and several other well-known sialic acid-containing glycoproteins ( fetuin , alpha1-acid glycoprotein , thyroglobulin and bovine submaxillary mucin ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
147,
152
]
} | {
"id": "C0002210",
"name": "fetuin",
"pos": [
240,
246
]
} |
the application of a combined histofluorescence-immunocytochemical and radioautographic technique on the same rat hypothalamus has revealed : 1 ) a close correlation between the dopaminergic fibers and lh-rh containing axons all along the external layers of the me , 2 ) a probable origin within the periventricular hypothalamus of some of the srif containing axons evidenced in the external zone of the me , 3 ) the exclusive location within the internal me of the axons originating within the supraoptic nuclei , 4 ) the ending within the external me of the axons originating within the medial paraventricular nuclei . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
114,
126
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
344,
348
]
} |
the pattern of the endothelial plasminogen activator activity at different ages and anatomical areas of the aorta , in combination with the corresponding pattern of the aortic endothelial cell turnover , gives valuable information about the mechanism ( s ) of the production and normal ( nonstressed ) release of the endothelial plasminogen activator . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial cell",
"pos": [
176,
192
]
} | {
"id": "C0032144",
"name": "plasminogen",
"pos": [
329,
340
]
} |
the increased release of alanine by uremic muscle was not accounted for by decreased rates of medium alanine reutilization via oxidation to co ( 2 ) or incorporation into muscle protein . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
43,
49
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
171,
185
]
} |
the reexpression of both proteins in two distinct tumor types arising from endodermal origins ( yolk sac and liver ) , suggests that these markers may represent reemerging fetal gene products , a phenomenon previously proposed only for alpha-fetoprotein , a prototypic `` '' oncofetal antigen . '' '' | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
109,
114
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
236,
253
]
} |
pituitary and serum levels of lh and fsh and hypothalamic gnrh content were measured in acyclic , congenitally athymic ( nu/nu ) female mice . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
45,
57
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
58,
62
]
} |
mucins secreted by the oesophagus , intestines and cloaca were predominantly acid-sulphated mucins , while the mucus neck cells of the gastric glands produced neutral mucins and the epithelial cells lining the gastric surface secreted a mixture of both neutral and acid mucins . | tissue_is_expression_site_of_gene_product | {
"id": "C0014597",
"name": "epithelial",
"pos": [
182,
192
]
} | {
"id": "C0026682",
"name": "mucins",
"pos": [
270,
276
]
} |
when human blood lymphocytes are cultured in vitro without any intended stimulus , they produce activities in the supernatant resembling lymphokine . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "blood lymphocytes",
"pos": [
11,
28
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
137,
147
]
} |
addition of these compounds to human erythrocyte suspensions resulted in stimulation of hexose monophosphate shunt activity that was markedly impaired in the absence of oxyhemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
37,
48
]
} | {
"id": "C0030069",
"name": "oxyhemoglobin",
"pos": [
169,
182
]
} |
red cell oxidant sensitivity in 15 patients was assessed by incubating red cells with ascorbate-cyanide and measuring methemoglobin which averaged 2.17 +/- 0.42 g/100 ml ( sem ) before dialysis and 2.87 +/- 0.52 g/100 ml after dialysis ( ns ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
71,
80
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
118,
131
]
} |
despite a clear induction of intracellular 5-ht fluorescence in pancreatic islets neither the pattern nor the total amount of insulin released were significantly modified after perfusion with either glucose or tolbutamide . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
64,
81
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
126,
133
]
} |
control of luteinizing hormone release in prepubertal female rats : evidence for an enhanced ability of the hypothalamus to release luteinizing hormone releasing hormone as the pituitary responsiveness to luteinizing hormone releasing hormone declines . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
108,
120
]
} | {
"id": "C0023610",
"name": "luteinizing hormone releasing hormone",
"pos": [
205,
242
]
} |
the data support a model in which mlsa determinants are recognized by a separate t cell structure , which we envisage as a monomorphic accessory molecule unrelated to the tcr . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell structure",
"pos": [
81,
97
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
171,
174
]
} |
there is an increase in the expression of thy-1 , l3t4 , il-2r , t cell activating protein , t cell receptor , and t3 complex on the surface of cultured cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
65,
71
]
} | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
93,
108
]
} |
t cells sharing a tcr determinant defined by such an antibody presumably use the same or similar tcr v or j genes for their alpha- or beta-chains . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
0,
7
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
97,
100
]
} |
since autoantigen specific t cells may play an important role in initiating autoimmune diseases , tcr were analyzed in different autoimmune diseases and control groups including rheumatoid arthritis , graves disease , idiopathic thrombocytopenic purpura , psoriasis , sle , insulin-dependent diabetes mellitus , and in nonautoimmune control diseases and normals . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
27,
34
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
98,
101
]
} |
immunoperoxidase staining of psoriatic lesional skin showed no striking enrichment of t cells bearing one or the other tcr type . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
86,
93
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
119,
122
]
} |
these studies have revealed that the t cells possessing the two classes of tcr occupy distinct histologic microenvironments . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
37,
44
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
75,
78
]
} |
when a number of control cell lines were analyzed under identical circumstances , similar effects were observed with most long term t cell lines or clones expressing a t cell receptor , whereas cells of non-t lineages and t cells not expressing a t cell receptor did not show the phenomena . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
222,
229
]
} | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
247,
262
]
} |
pancreatic islets were isolated from rats aged 3 , 6 and 12 weeks and their insulin secretory response to glucose or arginine was tested . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
0,
17
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
76,
83
]
} |
current understanding of control of gh release in animal models suggests that the slow-rising , frequently discontinuous natural peaks of gh in human blood are likely to be caused by interaction between the withdrawal of inhibitory hypothalamic somatostatin and the increased secretion of stimulatory grf . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
232,
244
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
245,
257
]
} |
current understanding of control of gh release in animal models suggests that the slow-rising , frequently discontinuous natural peaks of gh in human blood are likely to be caused by interaction between the withdrawal of inhibitory hypothalamic somatostatin and the increased secretion of stimulatory grf . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
232,
244
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
301,
304
]
} |
in this study , we have investigated the rearrangement and expression of delta and gamma genes in t cell hybridomas that express gamma/delta t cell receptors . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t",
"pos": [
3,
4
]
} | {
"id": "C0085246",
"name": "gamma/delta t cell receptors",
"pos": [
129,
157
]
} |
a panel of t cell hybridomas specific for p12-26 in the context of either i-ek or i-ad have been isolated to further understand the molecular interaction between the tcr and the ia-p12-26 complex , the primary structures of the tcr of five t cell hybridomas have been determined . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t",
"pos": [
11,
12
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
228,
231
]
} |
because class i mhc antigens function as restricting elements recognized by t cell antigen receptors , we sought to determine if there is preferential association between as and particular t cell ( tcr ) alleles . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
76,
82
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
198,
201
]
} |
as far as untreated tumor-bearing mice are concerned , the serum values of both pap and psa proved to be strictly dependent on the tumor volume measured . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "pap",
"pos": [
80,
83
]
} | {
"id": "C0138741",
"name": "psa",
"pos": [
88,
91
]
} |
erythrocyte ( rbc ) count , packed cell volume ( pcv ) and haemoglobin ( hb ) values were found to be higher in nigerian domestic fowls than those in hubbard fowls . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
14,
17
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
59,
70
]
} |
plasma levels of the platelet-specific protein thrombospondin rose progressively from 918 +/- 89 ng/ml to 1465 +/- 239 ng/ml ( delta 548 +/- 179 ng/ml ) at 30 minutes of extracorporeal membrane oxygenation , which indicates extensive release of platelet granule contents ( p less than 0.05 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
21,
29
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
47,
61
]
} |
reducing the incubation temperature of the hypothalami to 4 degrees c caused a reversible inhibition of basal i-crf release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
43,
54
]
} | {
"id": "C0010132",
"name": "i-crf",
"pos": [
110,
115
]
} |
thymus-derived lymphocytes ( t cells ) recognize antigen in the context of class i or class ii molecules encoded by the major histocompatibility complex ( mhc ) by virtue of the heterodimeric alpha beta t-cell receptor ( tcr ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
29,
36
]
} | {
"id": "C0085247",
"name": "alpha beta t-cell receptor",
"pos": [
192,
218
]
} |
in the first 4 days all red cells were nucleated and four hb types were present . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
24,
33
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
58,
60
]
} |
for a precise comparison between red cell and hb solutions data , the cells were fractionated to reduce cellular heterogeneity and depleted of their 2,3-diphosphoglycerate ( dpg ) content . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
33,
41
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
46,
48
]
} |
pregnant a/j ( high erythrocyte gk activity 134.18 +/- 17.89 mu/gm hb ) and c57bl/6j ( low erythrocyte gk activity 55.05 +/- 11.39 mu/gm hb ) mice were treated with a diet containing either 25 % or 50 % galactose throughout gestation . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
20,
31
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
137,
139
]
} |
there was no significant difference in mean percent variation between patient groups ( cancer , benign , and normal prostate glands ) for both the psa and pap assays . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostate glands",
"pos": [
116,
131
]
} | {
"id": "C0138741",
"name": "psa",
"pos": [
147,
150
]
} |
these results suggest that the ca innervation of the hypothalamus exerts a stimulatory control on crh-41-secreting neurons not only directly at the perikaryal level but also at other hypothalamic sites of vnab innervation including peripheral contacts between the terminals of ca and crh nerves in the external me . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
183,
195
]
} | {
"id": "C0010132",
"name": "crh",
"pos": [
284,
287
]
} |
inhibition of feline infectious peritonitis virus replication by recombinant human leukocyte ( alpha ) interferon and feline fibroblastic ( beta ) interferon . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblastic",
"pos": [
125,
137
]
} | {
"id": "C0015980",
"name": "beta",
"pos": [
140,
144
]
} |
we conclude that two restricting points control the induction of il-2 responsiveness ( activation ) in antigen-driven lyt-2+ t-cell responses , that is , cross-linking of tcr by way of presented antigen and `` '' costimulator '' '' activity expressed by accessory cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-cell",
"pos": [
125,
131
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
171,
174
]
} |
thyroid cells , prelabelled with 125i-iodide to generate 125i-thyroglobulin , were incubated in the absence of in the presence of inhibitors of intralysosomal proteolysis . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
0,
7
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
62,
75
]
} |
treatment of prelabelled thyroid cells with chloroquine and leupeptin induced the accumulation of immunoprecipitable 125i-thyroglobulin into a lysosome fraction corresponding to the l2 subpopulation . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
25,
32
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
122,
135
]
} |
in seven patients with hcl we have investigated how the cytokines tnf , alpha and gamma ifn and il2 modify the interactions between hcl lymphocytes and mhc unrestricted cytotoxic effector cells [ natural killer ( nk ) and lymphokine activated killer ( lak ) , cells ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
136,
147
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
222,
232
]
} |
a pyridoxylated-hemoglobin-polyoxyethylene conjugate ( php ) was developed from outdated human red cell hemoglobin through chemical modifications . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
95,
103
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
104,
114
]
} |
the viscous behavior of the leh suspensions was non-newtonian and nearly the same as suspensions of natural rbc prepared similarly , though leh suspensions had slightly higher viscosity . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
108,
111
]
} | {
"id": "C0019046",
"name": "leh",
"pos": [
140,
143
]
} |
sex differences in the responses of hypothalamic luteinizing hormone-releasing hormone and catecholamine systems to ovarian hormones and naloxone : implications for sexual differentiation of luteinizing hormone secretion in rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
36,
48
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing",
"pos": [
49,
78
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.