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|---|---|---|---|
bf1 and anti-cd3 , in combination , would be useful in identifying t-cell lesions with aberrant or unusual tcr-cd3 phenotypes . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-cell",
"pos": [
67,
73
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
107,
110
]
} |
these results indicate that the activated cell types found in eal were predominantly natural killer/lymphokine-activated killer-like with a small contribution from t-cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "eal",
"pos": [
62,
65
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
100,
110
]
} |
pit-1 mrna is expressed exclusively in the anterior pituitary gland in both somatotroph and lactotroph cell types , which produce growth hormone and prolactin , respectively . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior",
"pos": [
43,
51
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
149,
158
]
} |
and ( 4 ) untreated monocytes in culture showed an apparently mtp-pe-insensitive increase in size , density , and beta 2-microglobulin , hla-dr , and cd14 antigen expression . | tissue_is_expression_site_of_gene_product | {
"id": "C0026473",
"name": "monocytes",
"pos": [
20,
29
]
} | {
"id": "C0108768",
"name": "cd14 antigen",
"pos": [
150,
162
]
} |
plasma is incubated with activator venom in the presence or absence of antibody to human protein c in the instrument , chromogenic substrate ( s-2366 ) is added , and the absorbance is measured at 405 nm . | tissue_is_expression_site_of_gene_product | {
"id": "C0032105",
"name": "plasma",
"pos": [
0,
6
]
} | {
"id": "C1949480",
"name": "human protein c",
"pos": [
83,
98
]
} |
urinary transferrin , serum prostatic acid phosphatase ( pap ) and prostatic-specific antigen ( psa ) concentrations were measured in patients with prostatic cancer , prostatitis , benign prostatic hypertrophy ( bph ) and in a control group . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
28,
37
]
} | {
"id": "C0138741",
"name": "psa",
"pos": [
96,
99
]
} |
the genes for the alpha 1 ( iv ) and alpha 2 ( iv ) chains of human basement membrane collagen type iv are arranged head-to-head and separated by a bidirectional promoter of unique structure . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
68,
85
]
} | {
"id": "C0009333",
"name": "collagen type iv",
"pos": [
86,
102
]
} |
the human basement membrane specific collagen type iv is a heterotrimer composed of two alpha 1 ( iv ) chains and one alpha 2 ( iv ) chain . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
10,
27
]
} | {
"id": "C0009333",
"name": "collagen type iv",
"pos": [
37,
53
]
} |
when fish bearing an implanted rostral pars distalis of the pituitary gland are exposed to water of ph 4 , both the in situ prolactin cells and the prolactin cells of the implant become activated only when the drop in water ph is acute and followed by a reduction in plasma osmolarity and electrolyte levels . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "pars distalis of",
"pos": [
39,
55
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
148,
157
]
} |
using two different antisera , one raised against total human pancreatic growth hormone releasing factor ( hpgrf ) coupled through a two-step glutaraldehyde method and the other one raised against rat hypothalamic growth hormone releasing factor 1-10 ( rgrf1-10 ) , grf-like immunoreactivity was localized in the hypothalamo-hypophyseal system of the frog ( rana temporaria ) and the sea bass ( dicentrarchus labrax ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
201,
213
]
} | {
"id": "C0037668",
"name": "growth hormone",
"pos": [
214,
228
]
} |
using two different antisera , one raised against total human pancreatic growth hormone releasing factor ( hpgrf ) coupled through a two-step glutaraldehyde method and the other one raised against rat hypothalamic growth hormone releasing factor 1-10 ( rgrf1-10 ) , grf-like immunoreactivity was localized in the hypothalamo-hypophyseal system of the frog ( rana temporaria ) and the sea bass ( dicentrarchus labrax ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
201,
213
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
266,
269
]
} |
the fourth class of sertoli cell secretion products includes those proteins which contribute to the basement membrane , namely , type iv collagen and laminin . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
100,
117
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
129,
136
]
} |
to study whether this event is exclusively associated with proliferation of b lymphocytes , we examined the synthesis of numatrin in t lymphocytes ( murine and human ) activated by lectins or by anti-t cell antigen receptor monoclonal antibody and in swiss 3t3 fibroblasts stimulated by growth factors . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t",
"pos": [
0,
1
]
} | {
"id": "C0034790",
"name": "t cell antigen",
"pos": [
200,
214
]
} |
we showed a close correlation between induction of dna synthesis and induction of numatrin synthesis in t lymphocytes stimulated by concanavalin a , anti-t cell antigen receptor monoclonal antibody , and il-2 in murine t cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
104,
117
]
} | {
"id": "C0034790",
"name": "t cell antigen receptor",
"pos": [
154,
177
]
} |
western blotting experiments revealed that thyroid microsomal 103k proteins recognized by mouse monoclonal and polyclonal anti-tpo antibodies were recognized by some monoclonal anti-tg antibodies and anti-tg autoantibodies , and conversely , that 19s tg was recognized by some monoclonal anti-tpo antibodies . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
43,
50
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
251,
253
]
} |
direct evidence that cd2 binds dxs was demonstrated by the ability of dxs-coupled fibers to totally deplete the cd2 ag from lysates of radiolabeled human t lymphocytes and by the quantitative recovery of the cd2 ag in fiber eluates . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
154,
167
]
} | {
"id": "C0108773",
"name": "cd2 ag",
"pos": [
208,
214
]
} |
stimulation of human t cells by antibodies that bind the cd2 molecule is an alternate mode of inducing t cell proliferation . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
21,
28
]
} | {
"id": "C0108773",
"name": "cd2 molecule",
"pos": [
57,
69
]
} |
moreover , these data suggest that cd7+ , cd2+ , cytoplasmic cd3+ t cell precursors in man give rise to both tcr-delta+ t cells as well as to t cells expressing tcr-alpha beta . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
120,
127
]
} | {
"id": "C0085247",
"name": "tcr-alpha beta",
"pos": [
161,
175
]
} |
these data show that human gonadotrophin-secreting adenomas demonstrate variable stimulatory responses to hypothalamic trh and gnrh , and that during chronic treatment with a gnrh agonist the anticipated desensitizing effect of the drug was not observed in two out of the three adenomas studied . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
106,
118
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
175,
179
]
} |
herein , we present evidence that the predominant t cells raised in the syngeneic response to both spontaneous and transplantable rcs tumors are of the v beta 17a tcr clonotype . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
50,
57
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
163,
166
]
} |
analyses of tcr-bearing murine and human t cells have defined a unique subpopulation of t cells that express the tcr-gamma/delta proteins . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
41,
48
]
} | {
"id": "C0085246",
"name": "tcr-gamma/delta",
"pos": [
113,
128
]
} |
this effect was transient and rebound increases in circulating lymphocytes expressing high nk and lymphokine-activated killer functions were demonstrated at the end of a 4 day il-2 infusion . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
63,
74
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
98,
108
]
} |
to further characterize the mechanisms responsible for defective interleukin-2 ( il-2 ) production in patients with systemic lupus erythematosus ( sle ) , we studied the effect of irradiation on the capacity of lymphocytes to produce this lymphokine when stimulated with phytohemagglutinin ( pha ) , or with a combination of pha and a phorbol myristic acid ester ( pma ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
211,
222
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
239,
249
]
} |
five simian virus 40 ( sv40 ) -hepatocyte cell lines were examined for tumorigenicity and the effect of in vitro passage on the expression of four liver-specific genes ( albumin , transferrin , alpha 1-antitrypsin , and phosphoenolpyruvate carboxykinase ) , two oncogenes ( c-ha-ras and c-raf ) , and two genes associated with hepatocarcinogenesis ( alpha-fetoprotein and placental-type glutathione-s-transferase ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
147,
152
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
350,
367
]
} |
the t-cell repertoire found in the periphery is thought to be shaped by two developmental events in the thymus that involve the antigen receptors of t lymphocytes . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-cell",
"pos": [
4,
10
]
} | {
"id": "C0034790",
"name": "antigen receptors",
"pos": [
128,
145
]
} |
we now report that in the periphery of transgenic mice expressing ld , functional t cells bearing the 2c t-cell receptor were deleted . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
82,
89
]
} | {
"id": "C0034790",
"name": "t-cell receptor",
"pos": [
105,
120
]
} |
second , csa-treated mice show incomplete deletion of t cells expressing t-cell receptor molecules reactive to self h-2 i-e molecules . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
54,
61
]
} | {
"id": "C0034790",
"name": "t-cell",
"pos": [
73,
79
]
} |
hypophyseal and ovarian receptors for the neurohormone lhrh ( lhrh-r ) have been measured in young ( 3-4 months ) , middle-aged ( 8-11 months ) , constant estrous ( ce , 10-14 months ) and pseudopregnant ( pr , 16-18 months ) rats in order to study whether changes in hypothalamic and/or peripheral lhrh-like peptide production might precede and/or accompany the onset of reproductive failure observed in aging rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
268,
280
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
299,
303
]
} |
we speculated that in patients with ham , htlv-i-specific , mhc class ii antigen restricted , activated cd4+ cells could damage the mhc class ii antigen + htlv-i-infected astrocytes , leading to the disturbance of blood-brain barrier and to the destructive lesion in the central nervous system . | tissue_is_expression_site_of_gene_product | {
"id": "C0039215",
"name": "cd4",
"pos": [
104,
107
]
} | {
"id": "C0019630",
"name": "mhc class ii antigen",
"pos": [
132,
152
]
} |
among components of red cells , methemoglobin , methemalbumin , catalase and nicotinamid adenin dinucleotide ( nadh ) caused constriction of basilar artery in cats , when applied topically , whereas hematin , hemin and bilirubin caused no significant spasm . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
20,
29
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
32,
45
]
} |
in the regenerating liver alpha-fetoprotein was encountered independently of the two other proteins , although it was revealed in the same zones . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
20,
25
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
26,
43
]
} |
we measured red blood cell 2,3-diphosphoglycerate ( 2,3-dpg ) , adenosine triphosphate ( atp ) , and the p50 value in vitro of the oxyhemoglobin dissociation curve , which is the oxygen tension at half saturation of hemoglobin , in order to quantitate red blood cell oxygen transport function in individuals who were diagnosed as hypothyroid , euthyroid , or hyperthyroid based on measurements of thyroxine ( t4 ) , triiodothyronine ( t3 ) , thyrotropin ( tsh ) , and their clinical status . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
12,
26
]
} | {
"id": "C0030069",
"name": "oxyhemoglobin",
"pos": [
131,
144
]
} |
although these experiments do not preclude an effect of danazol directly on the pituitary , the results indicate that this agent probably lowers serum lh primarily by inhibition of hypothalamic lhrh secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
181,
193
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
194,
198
]
} |
[ role of hypothalamic somatostatin in the regulation of growth hormone secretion in the rat ( author 's transl ) ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
10,
22
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
23,
35
]
} |
series of studies were performed to elucidate the role of hypothalamic somatostatin in the regulation of growth hormone ( gh ) release in rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
58,
70
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
71,
83
]
} |
in the first series of experiments , the effects of hypophysectomy , thyroidectomy , the administration of hgh and thyroxine on the hypothalamic somatostatin content were examined . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
132,
144
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
145,
157
]
} |
these findings suggest that the major portion of hypothalamic somatostatin was provided by other regions of the brain , which did not play a role in mediating stress-induced plasma gh reductions , but appeared to be responsible for maintaining basal gh levels . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
49,
61
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
62,
74
]
} |
the action of the purified thymic factor , thymopoietin , on populations of post-thymic lymphocytes has been studied . | tissue_is_expression_site_of_gene_product | {
"id": "C0040113",
"name": "thymic",
"pos": [
27,
33
]
} | {
"id": "C0040105",
"name": "thymopoietin",
"pos": [
43,
55
]
} |
carcinoembryonic antigen was elevated in all 27 prostate epithelial-cell culture fluids tested , 24 of which had more than 20 ng . carcinoembryonic antigen per milliliter . | tissue_is_expression_site_of_gene_product | {
"id": "C0014597",
"name": "epithelial-cell",
"pos": [
57,
72
]
} | {
"id": "C0007082",
"name": "carcinoembryonic antigen",
"pos": [
131,
155
]
} |
[ immunoprofile of lmif in immunologic deficiency syndromes . i. lymphocytes suppressing lymphokines in mixed lymphocyte culture ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
65,
76
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
89,
100
]
} |
inorganic mercury incorporated into erythrocyte in the absence of selenite was mainly present in the fractions which were eluted from sephadex g-200 column just after hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
36,
47
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
167,
177
]
} |
on the other hand selenium incorporated into erythrocyte in the absence of mercury was eluted in hemoglobin fractions and also in those which are almost completely retained by the column . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
45,
56
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
97,
107
]
} |
other hypothalamic substances tested ( thyrotropin-releasing hormone , luteinizing hormone-releasing hormone , and substance p ) showed no lipogenic activity . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
6,
18
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
71,
108
]
} |
serial dilutions of rat hypothalamic extract gave a gradual change of antibody-bound alkaline phosphatase activity which was parallel to that with standard somatostatin . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
24,
36
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
156,
168
]
} |
release of immunoreactive and radioactively prelabelled endogenous ( pro ) -insulin from isolated islets of rat pancreas in the presence of exogenous insulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets",
"pos": [
98,
104
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
150,
157
]
} |
these results indicate that the afternoon lh surge is dependent on a transitory , enhanced release of gnrh from the hypothalamus , reflected by a depletion of gnrh stores . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
116,
128
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
159,
163
]
} |
bone marrow cells from a patient with severe combined immunodeficiency were studied in vitro for thymus-dependent lymphocyte ( t cell ) differentiation by using , at varying times , thymic epithelial monolayers and culture supernatants , thymopoietin , ubiquitin , and thymic extract as inducing agents . | tissue_is_expression_site_of_gene_product | {
"id": "C0040113",
"name": "thymic",
"pos": [
182,
188
]
} | {
"id": "C0040105",
"name": "thymopoietin",
"pos": [
238,
250
]
} |
it suggested that endogenous pgs in the anterior pituitary participate in the modulation of the sensitivity of this gland to the hypothalamic neurohormone , crf . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
129,
141
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
157,
160
]
} |
stimulation of the carboxylation reactions in the rabbits with experimental posthemorrhage anemia increases the intensity of 14co2 carbon transformation of organic compounds in the tricarboxylic cycle , intensifies 14c incorporation into the liver , kidneys , spleen and marrow proteins as well as into serum albumin and globulins . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
242,
247
]
} | {
"id": "C0017649",
"name": "globulins",
"pos": [
321,
330
]
} |
the effect of oral disodium ethane-1-hydroxy-1,1-diphosphonate , ehdp ( 20 mg kg-1 day-1 ) and placebo given for 28 days on plasma inorganic phosphate ( pi ) red cell 2,3-diphosphoglycerate and oxygen affinity of hemoglobin was evaluated in 14 insulin-treated diabetics and 5 healthy volunteers . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
158,
166
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
213,
223
]
} |
two enzyme fractions disappearing after the cyanide treatment were found in the erythrocyte lysates after the removal of hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
80,
91
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
121,
131
]
} |
oxyhemoglobin dissociation curve ( odc ) , erythrocytic variables , methemoglobin ( methb ) concentration and lung structure , particularly through electron microscopy studies , were investigated each week of exposure . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
43,
55
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
68,
81
]
} |
during the first year after vasectomy no obvious increase was observed in the occurrence of any of these antibodies ( rheumatoid factor , antinuclear antibodies and antibodies against smooth muscle , mitochondria , gastric parietal cell , thyroid microsomes and thyroglobulin ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
239,
246
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
262,
275
]
} |
in the hope of localizing thyroglobulin within focullar cells of the thyroid gland , antibodies raised against rat thyroglobulin were labeled with the enzyme horseradish peroxidase or with ( 125 ) i-radioiodine . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
69,
76
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
115,
128
]
} |
triiodothyronine ( t3 ) and thyroxine ( t4 ) were measured by radioimmunoassay in pronase hydrolysates of four lots each of 1- and 2-grain tablets of desiccated thyroid ( thyroid , armour ) and thyroglobulin ( proloid , warner-chilcott ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
161,
168
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
194,
207
]
} |
a simple multichannel perifusion apparatus of rat adenohypophysis and growth hormone and prolactin responses to partially purified bovine hypothalamic extracts ( 39878 ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "adenohypophysis",
"pos": [
50,
65
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
89,
98
]
} |
erythrocyte and hemoglobin concentrations in the blood remain constant , suggesting that the changes are driven by a feed-back mechanism . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
0,
11
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
16,
26
]
} |
the solubility of deoxyhemoglobin s was unaffected by the presence of red cell membrane ghosts , inside-out red cell vesicles , or inside-out vesicles enriched in erythrocyte spectrin and actin ( bands 1 , 2 , and 5 ) in the hemoglobin solution . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
163,
174
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
225,
235
]
} |
treatment of nude mice with thymic factors such as thymosin has been mostly ineffective in generating effector t cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0040113",
"name": "thymic",
"pos": [
28,
34
]
} | {
"id": "C0040106",
"name": "thymosin",
"pos": [
51,
59
]
} |
control and cll intact t cells , t cells with receptors for igg ( t gamma ) , and t cells without fc receptors at isolation ( t non-gamma ) were admixed with control b cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
23,
30
]
} | {
"id": "C0034790",
"name": "t cells",
"pos": [
82,
89
]
} |
application of this technique to the endocrine pancreas and gastrointestinal mucosa using antisera against insulin , glucagon , somatostatin , pancreatic polypeptide , gastrin , and neurotensin allowed these polypeptides to be localized in the secretory granules of the corresponding specific cell types . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "endocrine pancreas",
"pos": [
37,
55
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
107,
114
]
} |
tsh stimulated protein synthesis in calf thyroid slices , but this effect was masked by the simultaneous stimulation of thyroglobulin hydrolysis . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
41,
48
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
120,
133
]
} |
estrogen alters the responsiveness of the anterior pituitary gland to the actions of dopamine on lysosomal enzyme activity and prolactin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior pituitary gland",
"pos": [
42,
66
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
127,
136
]
} |
we conclude that either a reduced tg mcr or an increased thyroidal secretion of tg after endogenous tsh stimulation in the newborn is a possible explanation for the elevated tg levels occurring during the first days of life . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroidal",
"pos": [
57,
66
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
174,
176
]
} |
in this system , homogenates of hypothalamic tissue are subjected to hypoosmotic shock , and the lh-rh-containing granules are isolated by means of differential centrifugation . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
32,
44
]
} | {
"id": "C0023610",
"name": "lh-rh",
"pos": [
97,
102
]
} |
the effects of the hypothalamic 28 aminoacid peptide prosomatostatin ( pro-ss ) on arginine-induced growth hormone ( gh ) and prolactin ( prl ) release and blood glucose levels in man are compared with those obtained after an equimolar dose of somatostatin ( ss ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
19,
31
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
244,
256
]
} |
a pituitary site of action having been ruled out , this result supports the concept that exogenous somatostatin within the hypothalamus acts either to suppress the release of somatostatin from somatostatin-containing neurons , possibly via an ultrashort-loop feedback mechanism , or to augment release of hypothalamic growth hormone-releasing factor , thereby inducing a release of growth hormone . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
305,
317
]
} | {
"id": "C0037668",
"name": "growth hormone-releasing factor",
"pos": [
318,
349
]
} |
islets of langerhans were isolated by collagenase digestion and then either incubated in the presence of low or high concentrations of glucose for studies of insulin release or were sonicated and assayed for determinations of activities of adenylate cyclase and phosphodiesterase . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
0,
20
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
158,
165
]
} |
no significant differences ( nicotine vs control ) were seen in leukocyte , erythrocyte and platelet counts , or hematocrit and hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
76,
87
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
128,
138
]
} |
these antibodies reacted only with the glycoprotein portion of the basement membrane , and not with the type iv collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
67,
84
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
104,
120
]
} |
glycosylated hemoglobins are minor components of human red cell hemoglobin , structurally , they are closely related to adult hemoglobin and are formed nonenzymatically by condensation of glucose or other reducing sugars with hemoglobin a . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
55,
63
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
226,
236
]
} |
topical application of human fibroblast-derived ( beta ) interferon ( hulfn-beta ) has been used in treatment of epidemic keratoconjunctivitis due to adenovirus . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
29,
39
]
} | {
"id": "C0015980",
"name": "beta",
"pos": [
76,
80
]
} |
the increased lhrh content of the ovlt and of the mbh might be due to an enhanced lhrh synthesis and/or to the stimulation of neurons which inhibit lhrh release . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "mbh",
"pos": [
50,
53
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
148,
152
]
} |
the distribution of collagen type i and iii and of the basement membrane collagens type iv and alphaa ( alphab ) 2 in normal and fibrotic human livers has been studied by indirect immunofluorescence using type specific antibodies . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
55,
72
]
} | {
"id": "C0009333",
"name": "collagens type iv",
"pos": [
73,
90
]
} |
the method was designed for investigating the effects of physical or chemical treatment of whole muscle or whole animals by monitoring changes in individual muscle proteins . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
97,
103
]
} | {
"id": "C0026832",
"name": "muscle proteins",
"pos": [
157,
172
]
} |
thyroid gland nuclei were isolated , incubated in vitro in the presence of 32p-labeled uridine triphosphate , and thyroglobulin transcripts were quantitated by hybridization to immobilized rat thyroglobulin cdna clones . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid gland",
"pos": [
0,
13
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
193,
206
]
} |
investigations in 6 cases of congenital or acquired athyreosis show that serum thyroglobulin determined in these cases by radioimmunology is not due to a determination artifact or to another protein , but that , with regard to immunoreactivity , molar mass and isoelectric point , it displays all the features of the standard thyroglobulin of thyroid origin and of the serum thyroglobulin of normal subjects . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
343,
350
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
375,
388
]
} |
in patients with residual thyroid bed uptake the s-tg range was from less than 2 to 84 micrograms/l . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
26,
33
]
} | {
"id": "C0040123",
"name": "s-tg",
"pos": [
49,
53
]
} |
when anterior pituitary glands were incubated without hypothalami , gaba , bicuculline and picrotoxin had no effect on the release of prl or gh . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior pituitary glands",
"pos": [
5,
30
]
} | {
"id": "C0033371",
"name": "prl",
"pos": [
134,
137
]
} |
tg is measured during t4 treatment : in patients with no thyroid tissue , detectable tg levels indicated relapse requiring localisation by tbs . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
57,
64
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
85,
87
]
} |
patients with residual thyroid tissues and an elevated tg level probably have tumour recurrence , but in most cases , tg is within normal limits and no conclusions can be drawn . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
23,
30
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
118,
120
]
} |
alterations in hypothalamic content of luteinizing hormone-releasing hormone associated with pineal-mediated testicular regression in the golden hamster . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
15,
27
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
39,
76
]
} |
the present study was conducted to compare the effects of all three treatments on serum gonadotropin levels and testicular weights , and to evaluate the effects of these treatments on hypothalamic content of both immunoreactive and bioactive luteinizing hormone-releasing hormone ( lhrh ) levels . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
184,
196
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
242,
279
]
} |
each treatment group demonstrated increased hypothalamic content of immunoreactive lhrh which was temporally correlated with the decreases of serum gonadotropins . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
44,
56
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
83,
87
]
} |
these results indicate that there are temporal differences among the three common treatments and that these differences are manifested in serum gonadotropins , testicular weight and hypothalamic lhrh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
182,
194
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
195,
199
]
} |
hypothalamic lhrh levels determined by radioimmunoassay and bioassay show periods of increase and decrease which coincide with periods of altered serum gonadotropin levels in all groups . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
13,
17
]
} |
these il-2-independent t cells appeared to be derived from a discrete leu 8-negative subclass of t4+ cells and expressed the full complement of ia antigen of the donor . | tissue_is_expression_site_of_gene_product | {
"id": "C0039215",
"name": "t4",
"pos": [
97,
99
]
} | {
"id": "C0019630",
"name": "ia antigen",
"pos": [
144,
154
]
} |
to further delineate the relationship between gh-releasing factor ( grf ) and somatostatin ( srif ) in generation of the ultradian rhythm of gh secretion , we used two grf peptides , human pancreas ( hp ) grf-44 and rat hypothalamic ( rh ) grf , and studied their interaction with srif by passive immunization with a specific antiserum ( as ) to srif . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
220,
232
]
} | {
"id": "C0023610",
"name": "grf",
"pos": [
240,
243
]
} |
to further delineate the relationship between gh-releasing factor ( grf ) and somatostatin ( srif ) in generation of the ultradian rhythm of gh secretion , we used two grf peptides , human pancreas ( hp ) grf-44 and rat hypothalamic ( rh ) grf , and studied their interaction with srif by passive immunization with a specific antiserum ( as ) to srif . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
220,
232
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
346,
350
]
} |
we have incubated pancreatic islets isolated from noninbred ob/ob mice and nmri mice for 3 days with or without 5-hydroxytryptamine ( 5-ht ) in the medium and tested the effect of such long term treatment on subsequent insulin release and 86rb+ accumulation and efflux . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
18,
35
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
219,
226
]
} |
it can also bind to immobilized platelet-derived thrombospondin but not to immobilized gelatin or albumin . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
32,
40
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
49,
63
]
} |
purified platelet thrombospondin binds to fibronectin and fibrinogen immobilized on plastic surfaces with dissociation constants of 1.12 +/- 0.37 x 10 ( -7 ) m and 1.27 +/- 0.41 x 10 ( -7 ) m respectively , and to thrombospondin immobilized on plastic with dissociation constant of 4.82 +/- 1.01 x 10 ( -7 ) m . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
9,
17
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
214,
228
]
} |
it was also apparent that ifn-alpha , beta ( produced by fibroblasts ) and ifn-gamma ( produced by t lymphocytes ) activated trypanocidal activities in both 3t3 and j774 cells , although ifn-gamma was 100 to 2000 times more effective than ifn-alpha , beta on the basis of ifn antiviral units added per culture . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
57,
68
]
} | {
"id": "C0015980",
"name": "beta",
"pos": [
251,
255
]
} |
5 female patients with isolated hypothalamic hypogonadism were given subcutaneous pulses of gonadotrophin-releasing hormone ( gnrh ) , 2.5-15 micrograms every 90 min , for 2-6 months by means of an automated pump . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
32,
44
]
} | {
"id": "C0023610",
"name": "gonadotrophin-releasing hormone",
"pos": [
92,
123
]
} |
the cytoplasmic domain of the erythrocyte membrane protein , band 3 , contains binding sites for hemoglobin , several glycolytic enzymes , and ankyrin , the linkage to the cytoskeleton . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
30,
41
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
97,
107
]
} |
fast skeletal muscle myosin light chains 1 and 3 are produced from a single gene by a combined process of differential rna transcription and splicing . | tissue_is_expression_site_of_gene_product | {
"id": "C0242692",
"name": "skeletal muscle",
"pos": [
5,
20
]
} | {
"id": "C3815884",
"name": "myosin",
"pos": [
21,
27
]
} |
to further delineate the hypothalamic mechanism ( s ) responsible for hf , the basal levels and pulsatile release of lh , fsh , estradiol , and estrone and the rate of occurrence of hfs ( measured objectively ) were evaluated in patients with a defect of gnrh secretion [ isolated gonadotropin deficiency ( igd ) ] , patients with abnormalities of afferent input to gnrh neurons [ hypothalamic amenorrhea ( ha ) ] , and postmenopausal women with severe hfs . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
25,
37
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
366,
370
]
} |
erythrocytic thiols , both non-protein and protein-bound , were depleted in the presence of sporidesmin , whilst haemoglobin was oxidized to methaemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
0,
12
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
144,
155
]
} |
erythrocytic thiols , both non-protein and protein-bound , were depleted in the presence of sporidesmin , whilst haemoglobin was oxidized to methaemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
0,
12
]
} | {
"id": "C0025635",
"name": "methaemoglobin",
"pos": [
141,
155
]
} |
because direct cell contact between lymphocytes and infected macrophages is required to achieve a maximum leishmanicidal effect , this effect can not be attributed solely to lymphokines . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
36,
47
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
174,
185
]
} |
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