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antibodies were used against the following components of the dermis : type i and type vi collagens , aminopropeptide of type i and type iii procollagens , fibronectin , elastin , microfibrillar proteins , and basement membrane represented by the 7s domain of type iv collagen , laminin , and nidogen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
209,
226
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
259,
275
]
} |
stroma-free red blood cell hemolysate , stroma-free hemoglobin , zinc-precipitated hemoglobin , and chromatographically purified hemoglobin were infused . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
12,
26
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
129,
139
]
} |
enzymes considered to be markers for neurons ( angiotensin converting enzyme , thermolysin-like metalloendopeptidase , alanine aminopeptidase , and glutamate-oxaloacetate transaminase ) , glia ( glutamine synthetase , pyruvate carboxylase , and beta-glucuronidase ) , and endothelial cells ( alkaline phosphatase and plasminogen activator ) were measured in caudate nucleus from 10 sudden death controls , eight agonal state controls , and 16 huntington 's disease patients . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial cells",
"pos": [
272,
289
]
} | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
317,
338
]
} |
it appears that only these t lymphoblasts sensitized on thyroid monolayers are specifically labelled by fluorescein-conjugated thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
56,
63
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
127,
140
]
} |
the anterior pituitary gland , which is derived from a common primordium originating in rathke 's pouch , contains phenotypically distinct cell types , each of which express discrete trophic hormones : adrenocorticotropic hormone ( acth ) , thyroid-stimulating hormone ( tsh ) , prolactin , growth hormone , and follicle stimulating hormone ( fsh ) /luteinizing hormone ( lh ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior pituitary gland",
"pos": [
4,
28
]
} | {
"id": "C0040160",
"name": "thyroid-stimulating hormone",
"pos": [
241,
268
]
} |
the anterior pituitary gland , which is derived from a common primordium originating in rathke 's pouch , contains phenotypically distinct cell types , each of which express discrete trophic hormones : adrenocorticotropic hormone ( acth ) , thyroid-stimulating hormone ( tsh ) , prolactin , growth hormone , and follicle stimulating hormone ( fsh ) /luteinizing hormone ( lh ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "anterior pituitary gland",
"pos": [
4,
28
]
} | {
"id": "C0033371",
"name": "prolactin",
"pos": [
279,
288
]
} |
[ treatment of severe combined immune deficiency with fetal thymus and bone marrow transplantation , as well as with thymosin ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0040113",
"name": "thymus",
"pos": [
60,
66
]
} | {
"id": "C0040106",
"name": "thymosin",
"pos": [
117,
125
]
} |
in the dog prostate gland , the concentrations of 5 alpha-reductase and the cytosol estrophile in the nss epithelium were 1.58 and 0.43 of the nss muscle , respectively . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostate gland",
"pos": [
11,
25
]
} | {
"id": "C0039602",
"name": "5 alpha-reductase",
"pos": [
50,
67
]
} |
most of the efferences leave the hypothalamus as exohypothalamic fibres and form a system of somatostatin fibres which extends from the telencephalon to the medulla oblongata . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
33,
45
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
93,
105
]
} |
surgical and autopsy specimens of normal pancreas from three human adults were submitted to morphometry of langerhans islets and so-called extra insular islet cells , by measuring the islet radii on serial sections immunostained for either insulin or glucagon . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet",
"pos": [
118,
123
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
240,
247
]
} |
the data demonstrate that the activity of the hypothalamic-hypophyseal-gonadal ( h-h-g ) axis , evaluated on the basis of the gn response to lhrh , depends on the body weight of the patient . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
46,
58
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
141,
145
]
} |
incubation of red cells with acetaldehyde in 1-150 mm concentration without cyanoborohydride reduction yielded hemoglobin bands of decreasing pl the appearance of which coincided with the disappearance of hb a and hb a1c . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red",
"pos": [
14,
17
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
214,
216
]
} |
since virtually all the oxygen carried by blood at normal hematocrit is reversibly bound to red blood cell hemoglobin , the distribution of oxygen within the microcirculation can be determined from measurements of hemoglobin concentration and hemoglobin oxygen saturation in vessels of the network . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
92,
106
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
243,
253
]
} |
cytotoxic lymphocytes were generated from bovine peripheral blood mononuclear leukocytes after in vitro stimulation with lymphokines that contained interleukin-2 . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
10,
21
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
121,
132
]
} |
the relative rate of synthesis of hexokinase ii in the skeletal muscle of the normal , streptozotocin-diabetic , and diabetic insulin-treated rat was determined by the rate of incorporation of [ 3h ] leucine into hexokinase ii and the total cytosolic proteins to determine if the rate of hexokinase ii synthesis was altered relative to that of the average protein . | tissue_is_expression_site_of_gene_product | {
"id": "C0242692",
"name": "skeletal muscle",
"pos": [
55,
70
]
} | {
"id": "C0019475",
"name": "hexokinase ii",
"pos": [
288,
301
]
} |
at variance with the situation found in normal pancreatic islets , no equilibration of extracellular and intracellular d-glucose concentrations occurs in tumoral insulin-producing cells of the rinm5f line . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
47,
64
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
162,
169
]
} |
the significance of mu- and delta-receptors in rat pancreatic islets for the opioid-mediated insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
51,
68
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
93,
100
]
} |
to study if this was due to a direct effect on the endocrine pancreas , we examined the effects of furosemide and indapamide on the release of insulin and somatostatin from the isolated perfused pancreas of normal dogs . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "endocrine pancreas",
"pos": [
51,
69
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
143,
150
]
} |
we concluded that cya has a direct inhibitory effect on insulin release from human pancreatic islets with a concomitant increase in the residual insulin content . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
83,
100
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
145,
152
]
} |
we have isolated a cdna clone ( pciv-1-225 ) for the alpha 1 subunit of basement membrane ( type iv ) collagen from a cdna library made from engelbreth-holm-swarm mouse tumor rna . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement",
"pos": [
72,
80
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
92,
99
]
} |
the effects of chronic starvation ( 1/4 of ad libitum food intake ) for 21 or 30 days were studied on the hypothalamic and serum concentrations of lhrh , the pituitary and serum concentrations of lh , and the weights of the anterior pituitary , ovary and uterus in adult female wistar rats ( chronic starved group , csg ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
106,
118
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
147,
151
]
} |
effect of hydrostatic pressure ( hp ) on whole blood ( wb ) or erythrocyte suspension hemoglobin ( hb ) o2 affinity has been studied using newly developed techniques . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
63,
74
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
86,
96
]
} |
endothelial cells are known to release the two major forms of plasminogen activator , tissue plasminogen activator ( tpa ) and urokinase . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial cells",
"pos": [
0,
17
]
} | {
"id": "C0032144",
"name": "plasminogen",
"pos": [
93,
104
]
} |
endothelial cells are known to release the two major forms of plasminogen activator , tissue plasminogen activator ( tpa ) and urokinase . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial cells",
"pos": [
0,
17
]
} | {
"id": "C0042071",
"name": "urokinase",
"pos": [
127,
136
]
} |
characterization by immunofluorescence and sds page revealed that the isolated stbm retained fibronectin , laminin , and putative type iv collagen among its many components . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "stbm",
"pos": [
79,
83
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
130,
137
]
} |
this has been demonstrated in vitro as well as in vivo by the ability of antioxidant interventions or neutrophil or complement depletion procedures to prevent the appearance of osmotically fragile rbc and the release of hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
197,
200
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
220,
230
]
} |
this ameliorating effect of catecholamines on erythrocytic ph during a plasma acidosis maintains the oxygen-carrying capacity of the haemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
46,
58
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
133,
144
]
} |
all of these reactions were extensively inhibited by an antibody raised to purified human liver nifedipine oxidase cytochrome p-450 ( p-450nf ) , indicating a major role for this enzyme in the oxidation of these compounds . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
90,
95
]
} | {
"id": "C1142644",
"name": "nifedipine oxidase",
"pos": [
96,
114
]
} |
a distinct circulating antibody response could be evoked in c57bl mice after immunization with the globular domain nc1 of basement membrane collagen iv obtained from the mouse engelbreth-holm-swarm tumor when injected together with complete freund 's adjuvant . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
122,
139
]
} | {
"id": "C0009333",
"name": "collagen iv",
"pos": [
140,
151
]
} |
hyperglycemia in humans with pancreatic cancer is presumed to be caused by destruction of islets of langerhans with a resultant impairment in pancreatic insulin secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "of islets",
"pos": [
87,
96
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
153,
160
]
} |
in addition , immunoreactive material released from hypothalamus , spinal cord and hypothalamic and cortical synaptosomes inhibited somatotropin ( growth hormone , 'sth ' , 'gh ' ) release from perifused anterior pituitary in a dose-related manner , indicating biological similarity to synthetic somatostatin . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
83,
95
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
296,
308
]
} |
hypothalamic lhrh levels increased concurrently with the fall in lh and fsh , suggesting that lhrh release was decreased . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
94,
98
]
} |
increasing plasma gonadotropin levels and testicular recrudescence were associated with decreases in hypothalamic lhrh content . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
101,
113
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
114,
118
]
} |
ovariectomy of nonlactating , diestrous animals resulted in a significant decline in hypothalamic lhrh , reaching 50 % of control levels by 3 weeks . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
85,
97
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
98,
102
]
} |
inbred strains of mice are low- or high-responders with respect to the magnitude of thyroid infiltrates that appear after immunization with mouse thyroglobulin emulsified in freund 's complete adjuvant . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
84,
91
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
146,
159
]
} |
the thyroid appears to be an important site of thyroglobulin antibody production but the thyroid lymphocytes also contain many igg pfcs of non-thyroglobulin specificity . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
4,
11
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
143,
156
]
} |
discriminative effects of testosterone on hypothalamic luteinizing hormone-releasing hormone levels and luteinizing hormone secretion in castrated male rats : analyses of dose and duration characteristics . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
42,
54
]
} | {
"id": "C0023610",
"name": "luteinizing",
"pos": [
104,
115
]
} |
cathepsin d has been purified from rabbit thyroids , and its action on thyroglobulin has been examined . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroids",
"pos": [
42,
50
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
71,
84
]
} |
we have obtained evidence of thiol endopeptidases in the thyroid which are active in thyroglobulin degradation in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
57,
64
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
85,
98
]
} |
the results show that thiol endopeptidases are present in the thyroid gland and are collectively as important as cathepsin d in the hydrolysis of thyroglobulin in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid gland",
"pos": [
62,
75
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
146,
159
]
} |
the present studies examined the feasibility of performing in vivo biosynthetic studies of hypothalamic lhrh in preoptic area cannulated individual ovariectomized , estradiol benzoate ( eb ) -progesterone ( p ) treated rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
91,
103
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
104,
108
]
} |
these results demonstrate the feasibility of performing physiological studies on the biosynthesis and transport of hypothalamic lhrh using poa cannulated free-running female rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
115,
127
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
128,
132
]
} |
4 ) no difference in rbc , hematocrit , hemoglobin , mcv , mch , mchc , and intracellular water , sodium and potassium was observed between both groups . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
21,
24
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
40,
50
]
} |
thus , the high activity of the pancreatic islet branched-chain amino acid aminotransferase may be important for the recognition of l-leucine as an insulin secretagogue by pancreatic b-cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islet",
"pos": [
32,
48
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
148,
155
]
} |
our studies indicate a regional specificity for the control of srif secretion within the brain and suggests the possibility of a role for hypothalamic srif in metabolic regulation . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
138,
150
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
151,
155
]
} |
progress has been made in identifying and characterizing basement membrane macromolecules , including type iv collagen , laminin , a heparan sulfate proteoglycan and bullous pemphigoid antigen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
57,
74
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
102,
118
]
} |
basement membrane contains a unique collagen , type iv collagen , which is formed of pro alpha 1 ( iv ) ( mr = 185,000 ) and pro alpha 2 ( iv ) ( mr = 170,000 ) chains . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
0,
17
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
47,
63
]
} |
the possibility that immunity to basement membrane ( type iv ) collagen may be selective for scleroderma patients deserves further study . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
33,
50
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
53,
60
]
} |
endocrine pancreatic response of children with onset of insulin-requiring diabetes before age 3 and after age 5 . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "endocrine pancreatic",
"pos": [
0,
20
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
56,
63
]
} |
samples were analyzed for erythrocyte counts ( rbc ) , packed cell volume ( pcv ) , hemoglobin concentration ( hb ) , mean corpuscular volume ( mcv ) , mean corpuscular hemoglobin ( mch ) , and mean corpuscular hemoglobin concentration ( mchc ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
47,
50
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
111,
113
]
} |
human fibroblast cells treated with a combination of inhibitors of protein and rna synthesis [ cycloheximide and actinomycin d as used to superinduce interferon beta ( ifn-beta ) ] secrete two proteins with molecular masses of 22000 and 27000 kilodaltons ( called 22-kdal and 27-kdal ) that are precipitable with an antiserum raised against impure ifn-beta but are antigenically distinct from ifn-beta 1 . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
6,
16
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
393,
401
]
} |
lantana toxicity of guinea pigs elicited an increase in hematocrit , erythrocyte and leukocyte number , hemoglobin , urea-nitrogen and bilirubin contents in the blood of the affected animals . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
69,
80
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
104,
114
]
} |
this strict dependence of suppression of f1 hybrid t cells is interpreted as evidence that these cells probably suppress directly , via an anti-idiotypic mechanism , the alloreactive cells bearing idiotype-positive major histocompatibility complex receptors . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
51,
58
]
} | {
"id": "C0034790",
"name": "major histocompatibility",
"pos": [
215,
239
]
} |
red blood cell 2,3-diphosphoglycerate ( 2,3-dpg ) was significantly increased in the pregnant diabetic women ( p less than 0.01 ) , but the 2,3-dpg-induced change in hemoglobin-oxygen affinity was impaired . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
0,
14
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
166,
176
]
} |
we have prepared primary thyroid cell cultures of early bovine embryos from the first trimester of pregnancy in order to study the ontogeny of their interaction with tsh and thyroglobulin ( tg ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
25,
32
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
174,
187
]
} |
the three thyroidal properties probably develop independently since only part of the tg-containing cells bind tg or tsh , and a significant proportion of the cells that exhibit tg-binding do not bind tsh . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroidal",
"pos": [
10,
19
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
177,
179
]
} |
tritiated gp-160 could be immunoisolated from [ 3h ] leucine-labeled endothelial cell postculture medium using a rabbit antiserum to human platelet thrombospondin . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial cell",
"pos": [
69,
85
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
148,
162
]
} |
tritiated gp-160 could be immunoisolated from [ 3h ] leucine-labeled endothelial cell postculture medium using a rabbit antiserum to human platelet thrombospondin . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
139,
147
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
148,
162
]
} |
thus , endothelial cells secrete large amounts of a glycoprotein that is identical or very similar to platelet thrombospondin . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial cells",
"pos": [
7,
24
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
111,
125
]
} |
thus , endothelial cells secrete large amounts of a glycoprotein that is identical or very similar to platelet thrombospondin . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
102,
110
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
111,
125
]
} |
thyroid tissue from 18 consecutive cases of hashimoto 's thyroiditis treated surgically were stained immunohistochemically for neurone specific enolase ( nse ) , somatostatin , calcitonin and thyroglobulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
0,
7
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
192,
205
]
} |
all ten endometrioid prostatic adenocarcinomas showed prostate-specific antigen and prostate-specific acid phosphatase immunoreactivity , in contrast to none of the control uterine endometrial carcinomas . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
21,
30
]
} | {
"id": "C0138741",
"name": "prostate-specific antigen",
"pos": [
54,
79
]
} |
these results strongly suggest that human hypothalamic grf derives from a precursor immunologically related ( and probably identical ) to the tumorous one and that this precursor is cleaved inside grf cell bodies to give , in addition to the grf-44-nh2 a second amidated peptide , the c-terminal pre-progrf that is transported distally to nerve endings and most probably coreleased with grf into portal capillaries . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
42,
54
]
} | {
"id": "C0037668",
"name": "grf",
"pos": [
387,
390
]
} |
the objective of this study was to determine whether calcitonin can act directly on pancreatic islets in vitro to inhibit insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islets",
"pos": [
84,
101
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
122,
129
]
} |
the properties of fibrin around aggregating platelets , therefore , may be influenced considerably by secreted tsp . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelets",
"pos": [
44,
53
]
} | {
"id": "C0076560",
"name": "tsp",
"pos": [
111,
114
]
} |
the fibroblast activity of the monoclonal antibodies was lost if the antibodies were preincubated with thyroid membranes , was significantly decreased when fibroblasts were exposed to mild trypsin treatment before the assay , was not inhibited by human asialoagalacto-thyroglobulin , and required more than a tsh receptor determinant , since tsh alone neither duplicated nor inhibited the antibody activity . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
103,
110
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
268,
281
]
} |
these data suggest that iodine availability , which affects the degree of thyroid tg iodination , partially determines serum tg levels at birth . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
74,
81
]
} | {
"id": "C0040123",
"name": "tg",
"pos": [
125,
127
]
} |
in il 1-independent t cell lines , however , both of the activating signals studied may be delivered through stimulation of the antigen-mhc t cell receptor . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
20,
26
]
} | {
"id": "C0034790",
"name": "antigen",
"pos": [
128,
135
]
} |
immunoprecipitation of the labeled proteins after solubilization in non-ionic detergents , with monoclonal antibodies ( mabs ) directed against a family of leukocyte membrane proteins ( lfa-1 , mac-1 , p150,95 , and the beta subunit these glycoproteins share ) , indicated that mac-1 and p150,95 were bound by con a . | tissue_is_expression_site_of_gene_product | {
"id": "C0023516",
"name": "leukocyte",
"pos": [
156,
165
]
} | {
"id": "C0079785",
"name": "mac-1",
"pos": [
278,
283
]
} |
since basement membranes are thought to be a critical barrier to the passage of tumor cells , we have constructed a model basement membrane-stromal matrix consisting of laminin and type iv collagen reconstituted onto a disk of type i collagen for use in an in vitro assay of invasiveness . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
6,
23
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
181,
197
]
} |
the stable tri-glutathionyl derivative was actively transported across the red cell membrane with an apparent vmax = 1 nmol/min/ml red cell suspension ( 15 g hemoglobin/100 ml ) and km = 0.5 mm . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
75,
83
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
158,
168
]
} |
if there is no interaction between red cell hemoglobin and sfh , then the composite oxygen dissociation curve for whole blood ( wb ) can be written as : swb = rssfh + ( 1 - r ) srbc , where s is the fractional saturation , and r is the sfh/wb hemoglobin ratio . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
35,
43
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
243,
253
]
} |
these findings graphically demonstrate that rfi , or a sequelae of this nutritional perturbation , inhibits gonadotropin secretion , in the absence of feedback influences by gonadal hormones , by an action at a suprapituitary level that is mediated by interruption of intermittent hypothalamic gnrh discharge . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
281,
293
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
294,
298
]
} |
characterization of two murine monoclonal antibodies ( p10 , p12 ) directed against different determinants on human blood platelet thrombospondin . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "blood platelet",
"pos": [
116,
130
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
131,
145
]
} |
the aim of this study was to characterize two monoclonal antibodies ( p10 and p12 ) directed against human blood platelet thrombospondin . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "blood platelet",
"pos": [
107,
121
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
122,
136
]
} |
cells obtained by mechanical dispersion of isolated rat islets of langerhans were mixed with protein a-coated sheep red blood cells and incubated in the presence of an anti-insulin serum , under conditions known to affect insulin release . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "of",
"pos": [
40,
42
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
222,
229
]
} |
the isolated thermolysin-generated fragments of thrombospondins were identified by radioimmunoassays using either different monoclonal antibodies or a polyclonal antibody directed against platelet thrombospondin . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
188,
196
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
197,
211
]
} |
the results show that platelet and endothelial thrombospondins are both partially protected from trypsin digestion in the presence of calcium but have different trypsin and thermolysin fragmentation patterns . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
22,
30
]
} | {
"id": "C0076560",
"name": "thrombospondins",
"pos": [
47,
62
]
} |
the thermolysin-generated fragments from platelet and endothelial thrombospondins are recognized differently by a monoclonal antibody whereas all of them are identified by a polyclonal antibody . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelet",
"pos": [
41,
49
]
} | {
"id": "C0076560",
"name": "thrombospondins",
"pos": [
66,
81
]
} |
the islets of langerhans in sections from the pancreas tail of macaca nigra were stained by antiserum to insulin , glucagon , or somatostatin . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islets of langerhans",
"pos": [
4,
24
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
105,
112
]
} |
inhibition of erythrocyte superoxide dismutase by diethyldithiocarbamate also results in oxyhemoglobin-catalyzed glutathione depletion and methemoglobin production . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
14,
25
]
} | {
"id": "C0030069",
"name": "oxyhemoglobin",
"pos": [
89,
102
]
} |
inhibition of erythrocyte superoxide dismutase by diethyldithiocarbamate also results in oxyhemoglobin-catalyzed glutathione depletion and methemoglobin production . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
14,
25
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
139,
152
]
} |
these data suggest that after gh treatment , the blunted gh response to synthetic grf is not solely a consequence of the inhibition of hypothalamic grf secretion . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
135,
147
]
} | {
"id": "C0037668",
"name": "grf",
"pos": [
148,
151
]
} |
( c ) changes in pancreatic islet hormone secretion ( decrements in insulin , increments in glucagon , or both ) are not normally critical but become critical when catecholamine action is deficient . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "pancreatic islet",
"pos": [
17,
33
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
68,
75
]
} |
the gingival basement membrane antigens , type iv collagen , bullous pemphigoid antigen and epidermolysis bullosa acquisita antigen were studied by indirect immunofluorescence in 11 gingival specimens from patients with periodontitis and 2 normal gingival specimens . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
13,
30
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
42,
58
]
} |
pituitary secretion in vitro of lh and fsh in response to 1 pmol gnrh , as well as hypothalamic gnrh content , rose to peaks at 50 and 80 days of age respectively in animals exposed to long photoperiods . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
83,
95
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
96,
100
]
} |
hypothalamic gnrh content rose to a peak at 50 days of age and then declined . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
13,
17
]
} |
the relationship between the hypothalamic gnrh and the sensitivity of the pituitary to gnrh stimulation is compatible with the idea that gnrh can mediate its own receptor numbers . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
29,
41
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
137,
141
]
} |
by means of an indirect t-lymphocyte migration inhibitory factor assay , t-cell sensitisation to the asialoglycoprotein receptor , a liver-specific protein on the surface of hepatocytes , was found in patients with autoimmune chronic active hepatitis ( cah ) but not in healthy relatives or spouses . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-lymphocyte",
"pos": [
24,
36
]
} | {
"id": "C0034790",
"name": "t-cell",
"pos": [
73,
79
]
} |
measurable changes in platelets that are associated with the clinical complications of atherosclerosis include shortened survival , release of granule contents ( platelet factor 4 , beta-thromboglobulin , thrombospondin ) , formation of thromboxanes , and decreased buoyant density . | tissue_is_expression_site_of_gene_product | {
"id": "C0005821",
"name": "platelets",
"pos": [
22,
31
]
} | {
"id": "C0076560",
"name": "thrombospondin",
"pos": [
205,
219
]
} |
hypothalamic levels of lhrf in male mice of differing social status and from individual housing . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0023610",
"name": "lhrf",
"pos": [
23,
27
]
} |
the magnitude of this difference depends on ( a ) the oxygen content of the sample and thus is determined by the red blood cell content and by the state of oxygen saturation of hemoglobin , and ( b ) on the rate of dissociation of oxyhemoglobin and therefore is influenced by changes in ph , pco ( 2 ) , and temperature . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red blood cell",
"pos": [
113,
127
]
} | {
"id": "C0030069",
"name": "oxyhemoglobin",
"pos": [
231,
244
]
} |
[ in vitro reassociation of cells isolated from porc ine thyroid and the biosynthesis of thyroglobulin . i. conditions for the induction of cellular reassociations by thyreostimulin ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
57,
64
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
89,
102
]
} |
[ participation of thyroxine in the interaction of brain glutaminase isoenzymes and characteristics of its action ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0006104",
"name": "brain",
"pos": [
51,
56
]
} | {
"id": "C0017796",
"name": "glutaminase",
"pos": [
57,
68
]
} |
the procedure in the present study is based on the premise that fetal hemoglobin is not eluted from red cells in blood smears by an acid buffer , whereas adult hemoglobin is removed . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
100,
109
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
160,
170
]
} |
we conclude that the kidney and liver dbp mrnas are transcription products of the same dbp locus and that dbp , alpha fp , and alb genes display different spectra of tissue distribution . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
32,
37
]
} | {
"id": "C0002210",
"name": "alpha fp",
"pos": [
112,
120
]
} |
comparisons between the two groups of bats revealed that the number of lhrh perikarya detected immunocytochemically , as well as hypothalamic lhrh content , were significantly reduced in post-ovulatory animals . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
129,
141
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
142,
146
]
} |
parallel reductions in hypothalamic and neural lobe lhrh content during the periovulatory period support the hypothesis that the neural lobe component of the system contributes to control of gonadotrophin secretion in this species . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
23,
35
]
} | {
"id": "C0023610",
"name": "lhrh",
"pos": [
52,
56
]
} |
in human fibroblasts , expression of mxa and mxb is strongly induced by alpha interferon ( ifn-alpha ) , ifn-beta , newcastle disease virus , and , to a much lesser extent , ifn-gamma , mxa and mxb proteins have molecular masses of 76 and 73 kilodaltons , respectively , and their sequences are 63 % identical . | tissue_is_expression_site_of_gene_product | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
9,
20
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
105,
113
]
} |
the frequency of the detection of antibodies to microsomal thyroid antigen in autoimmune thyroid diseases was lower than that of antibodies to thyroglobulin and did not depend on a type of disease . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
59,
66
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
143,
156
]
} |
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