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stringlengths 57
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dict |
|---|---|---|---|
incubation of monocytes with lps induced icam-1 in the subpopulation which lacks it and increased its density on the cells which express it . | tissue_is_expression_site_of_gene_product | {
"id": "C0026473",
"name": "monocytes",
"pos": [
14,
23
]
} | {
"id": "C0063695",
"name": "icam-1",
"pos": [
41,
47
]
} |
we have explored the functional significance of these polymorphic regions in an i-ak-restricted , hen egg lysozyme specific ag presentation system in which the measurement of il-2 production by t cell hybridomas was used as the indicator of tcr recognition of the i-a/ag complex . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
194,
200
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
241,
244
]
} |
in the absence of oxygen , these red cells remain capable of ph regulation , but can not maintain ntp : hb constant . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
33,
42
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
104,
106
]
} |
the other dnase-hypersensitive region was also detected only in t cell lines but only in those expressing tcr-beta rna . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
64,
70
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
106,
109
]
} |
taken together , these results raise the possibility that some autoreactive t cells may persist after birth and that tcr downregulation may occur as a physiological response to tolerogenic signals in vivo . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
76,
83
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
117,
120
]
} |
differential analysis for the ratios of ifn-alpha and ifn-beta showed that cm- or m-csf-cultured macrophages produced equal amounts of both ifn species as determined by specific monoclonal antibodies and hybridization experiments using ifn-alpha and ifn-beta dna probes , whereas resident peritoneal macrophages induced under identical conditions produced almost exclusively ifn-beta . | tissue_is_expression_site_of_gene_product | {
"id": "C0024432",
"name": "m-csf",
"pos": [
82,
87
]
} | {
"id": "C0015980",
"name": "ifn-beta",
"pos": [
375,
383
]
} |
this study demonstrated that anti-gamma-sm antibody and anti-pa antibody recognized a single and identical antigen in seminal fluid and prostate homogenate and suggested that an identical material could be measured in sera of patients with prostate cancer by immunoassay systems using anti-gamma-sm antibody and anti-pa antibody . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostate",
"pos": [
136,
144
]
} | {
"id": "C0138741",
"name": "gamma-sm",
"pos": [
290,
298
]
} |
having no first pass effect on the liver , parenteral administrations have less influence than oral ones on the synthesis of certain proteins by the liver ( increased shbg , cbg , tbg , transferrin , ceruloplasmin , angiotensinogen , clotting factors vii , ix , x and x complex ; decreased antithrombin iii and anti xa ) and on lipid metabolism ( increased biliary cholesterol , triglycerides and hdl , especially hdl2 ; reduced ldl ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
35,
40
]
} | {
"id": "C0015502",
"name": "clotting factors vii",
"pos": [
234,
254
]
} |
the majority of t cells bear the t-cell receptor ( tcr ) alpha beta complex which recognizes foreign antigen peptides only in the context of self major histocompatibility complex ( mhc ) molecules . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
16,
23
]
} | {
"id": "C0085247",
"name": "t-cell receptor",
"pos": [
33,
48
]
} |
recently , a small subpopulation t cells was found to bear a distinct tcr composed of gamma and delta subunits . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
33,
40
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
70,
73
]
} |
t lymphocytes can be activated by various stimuli directed either against the t-cell antigen receptor-cd3 antigen complex ( ti-cd3 ) or the cd2 molecule ; | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
0,
13
]
} | {
"id": "C0108773",
"name": "cd2 molecule",
"pos": [
140,
152
]
} |
when the cell-free supernatant products of activated cloned t helper ( th ) cells were found to mediate helper activity with antigen specificity identical to that of intact t cells , experiments were carried out to determine whether this functional activity was mediated by a cell-free form of tcr-related material . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
173,
180
]
} | {
"id": "C0034790",
"name": "cell",
"pos": [
276,
280
]
} |
a disulfide-linked dimer indistinguishable from the t cell surface alpha beta heterodimer was precipitated from cell-free supernatants of cloned th cells with f23.1 , a monoclonal antibody specific for a tcr v beta 8 determinant . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
52,
58
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
204,
207
]
} |
these findings suggest that the factor isolated from t cell supernatants is a cell-free form of the tcr alpha beta dimer . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
53,
59
]
} | {
"id": "C0085247",
"name": "cell",
"pos": [
78,
82
]
} |
in this review of the pathophysiology of acute intracerebral and subarachnoid hemorrhage , information from several disciplines is assembled to describe the bleeding process , hemostasis and coagulation , fibrinolysis , erythrocyte lysis , phagocytosis , and changes in the state of hemoglobin . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
220,
231
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
283,
293
]
} |
examination included determination of blood erythrocytes and hemoglobin , serum plasma , changes of body weight , coprology , ecg and eeg . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "blood",
"pos": [
38,
43
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
61,
71
]
} |
one t-cell malignancy showed t-cell receptor and heavy-chain gene rearrangement , and one b-cell malignancy showed immunoglobulin and t-cell receptor gene rearrangement . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-cell",
"pos": [
4,
10
]
} | {
"id": "C0034790",
"name": "t-cell receptor",
"pos": [
134,
149
]
} |
but cddp runs the risk of renal and myelotoxicity , so we studied renal dysfunction after treatment by examining serum and urinary beta 2-microglobulin ( beta 2-m ) , and rbc , hb , wbc , lymphocyte , and plt . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
171,
174
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
177,
179
]
} |
rbc , hb , wbc , lymphocyte , and plt fell most at 3 weeks after treatment and then increased slowly . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
0,
3
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
6,
8
]
} |
hypothalamic somatostatin ( srif ) receptors were examined in a qualitative and quantitative radioautographic study using [ 125i-tyr0 , d-trp8 ] srif14 and the stable octapeptide analog [ 125i-tyr3 ] sms 201-995 as radioligands . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0037659",
"name": "srif",
"pos": [
145,
149
]
} |
new immunotherapeutic methods , particularly cyclosporine , monoclonal antibodies ( against t cells , cd4 and t cell receptor molecules and ia antigens ) and autoantigen-specific vaccination open new major therapeutic perspectives that presage major improvement in the prognosis of these diseases . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
92,
99
]
} | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
110,
125
]
} |
on the other hand , the agent did not inhibit the development of cd3+4-8- t cell receptor ( tcr ) alpha beta- cells , which were supposed to be t cells bearing gamma delta-tcr chains . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
144,
151
]
} | {
"id": "C0085246",
"name": "gamma delta-tcr",
"pos": [
160,
175
]
} |
this effect was seen on thymocytes and resting or preactivated t cells ( phytohemagglutinin blasts and alloproliferative t cell clones ) and could be observed , following the introduction of anti-lfa-1 or -icam-1 mabs , up to 50 hr after the cd2 stimulatory signal . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
63,
70
]
} | {
"id": "C0063695",
"name": "icam-1",
"pos": [
206,
212
]
} |
erythrocyte lysates from 97 apparently healthy individuals were assayed giving a mean erythrocyte porphobilinogen deaminase protein concentration of 150 +/- 28 sd ( micrograms/g hb ) and a specific enzyme activity of 750 +/- 140 sd ( nkat/g ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
0,
11
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
178,
180
]
} |
in the wallaby hypothalamic extract , a single form of gnrh was present , which eluted in the same position as synthetic mammalian gnrh on hplc and was recognized by antibodies directed against the nh2- and cooh-termini of mammalian gnrh as well as by antibodies to the middle region . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
15,
27
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
233,
237
]
} |
truncated , deleted or substituted peptide analogues did not distinguish between seven t cell clones that use different alpha/beta t cell receptors . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
87,
93
]
} | {
"id": "C0085247",
"name": "alpha/beta t cell",
"pos": [
120,
137
]
} |
induction of ctl tolerance was dependent on the maturation stages of t cells in the thymus : t cells in 5-day- , but not in 7-day-cultured thymuses were susceptible to tolerance induction , indicating that t cells expressing t cell receptors at low density are susceptible to tolerance induction . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
69,
76
]
} | {
"id": "C0034790",
"name": "t cell",
"pos": [
225,
231
]
} |
the hypothalamus and the testis of the frog , rana esculenta , contain gonadotropin-releasing hormone ( gn-rh ) -like peptides which are recognized by an antiserum raised against mammalian gn-rh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
4,
16
]
} | {
"id": "C0023610",
"name": "gn-rh",
"pos": [
189,
194
]
} |
[ studies of the methodologic value of perfusion of human placenta by the schneider method . iii . production of alpha hcg and beta hcg during bilateral perfusion of human cotyledon ] . | tissue_is_expression_site_of_gene_product | {
"id": "C0032043",
"name": "placenta",
"pos": [
58,
66
]
} | {
"id": "C0106132",
"name": "beta hcg",
"pos": [
127,
135
]
} |
while continuing the series of research into various aspects of human placental tissue during bilateral perfusion of after birth cotyledon in vitro , the authors made an attempt to evaluate the production of alpha hcg and beta hcg . | tissue_is_expression_site_of_gene_product | {
"id": "C0032043",
"name": "placental",
"pos": [
70,
79
]
} | {
"id": "C0106132",
"name": "beta hcg",
"pos": [
222,
230
]
} |
we analyzed the distribution of two basement membrane components , laminin and type iv collagen , in human reactive and neoplastic lymphoid follicles by using immunoenzymatic and immunofluorescence methods on serial frozen sections from 11 reactive lymph nodes , three palatine tonsils , and 11 immunophenotypically defined b cell non-hodgkin 's lymphomas . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
36,
53
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
79,
95
]
} |
we therefore isolated dog erythrocyte inhibitory factor ( deif ) from red blood cells to determine if deif was a hemoglobin derivative . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "deif",
"pos": [
58,
62
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
113,
123
]
} |
prolactin-secreting cells were not seen in the foetal adenohypophysis and did not start to increase until 10 days after birth , whereas by that time the number of acth , thyrotropin , follicle-stimulating and luteinizing hormone-secreting cells had stopped increasing . | tissue_is_expression_site_of_gene_product | {
"id": "C0032008",
"name": "adenohypophysis",
"pos": [
54,
69
]
} | {
"id": "C0040160",
"name": "thyrotropin",
"pos": [
170,
181
]
} |
the two caenorhabditis elegans basement membrane ( type iv ) collagen genes are located on separate chromosomes . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
31,
48
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
51,
58
]
} |
on northern blot analysis , human p-cadherin was scarcely expressed in human placenta in contrast to mouse p-cadherin , which was abundantly expressed in mouse placenta throughout pregnancy , and it was shown that e-cadherin , but not p-cadherin , was the major cadherin molecule in human placenta . | tissue_is_expression_site_of_gene_product | {
"id": "C0032043",
"name": "placenta",
"pos": [
77,
85
]
} | {
"id": "C0030128",
"name": "cadherin",
"pos": [
262,
270
]
} |
lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane ( type iv ) collagen . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
82,
99
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
102,
109
]
} |
we report a proteinase that degrades basement-membrane ( type iv ) collagen and is produced by the liver . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement-membrane",
"pos": [
37,
54
]
} | {
"id": "C0009333",
"name": "type iv",
"pos": [
57,
64
]
} |
distribution of t cells bearing different forms of the t cell receptor gamma/delta in normal and pathological human tissues . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
16,
23
]
} | {
"id": "C0085246",
"name": "t cell receptor",
"pos": [
55,
70
]
} |
purified t cells can be induced to proliferate and to produce the autocrine growth factor il-2 with mab to the tcr and costimulatory cytokines . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
9,
16
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
111,
114
]
} |
examination of macrophage cell surface antigen regulation by rifn-gamma and ifn-alpha/beta utilizing digital imaging by a novel laser detection system . | tissue_is_expression_site_of_gene_product | {
"id": "C0024432",
"name": "of",
"pos": [
12,
14
]
} | {
"id": "C0015980",
"name": "ifn",
"pos": [
76,
79
]
} |
additionally , qinghaosu resulted in a dose-dependent increase in red cell lysis and methemoglobin generation while decreasing reduced glutathione concentration . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
66,
74
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
85,
98
]
} |
additionally , deoxyqinghaosu had no effect on fatty acid composition , red cell lysis , methemoglobin generation , or reduced glutathione concentration . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
72,
80
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
89,
102
]
} |
in particular , murine mlsa and mlsc determinants have been shown to be highly stimulatory to allogeneic t cells and to be involved in the negative selection ( elimination ) of self-reactive t cells expressing selected tcr v beta segments . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
105,
112
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
219,
222
]
} |
anti-p75 il-2r mab almost completely inhibited the induction of cytolytic activity in these t cells by brief exposure to il-2 , as estimated by anti-tcr/cd3 mab-targeted cytotoxicity . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
92,
99
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
149,
152
]
} |
t cells expressing the alpha beta t-cell receptor ( tcr ) for antigen can elicit anti-idiotypic antibodies specific for the tcr that regulate t-cell function . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
0,
7
]
} | {
"id": "C0085247",
"name": "alpha beta t-cell receptor",
"pos": [
23,
49
]
} |
t cells expressing the alpha beta t-cell receptor ( tcr ) for antigen can elicit anti-idiotypic antibodies specific for the tcr that regulate t-cell function . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
0,
7
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
124,
127
]
} |
positive selection of cd4+ t cells mediated by mhc class ii-bearing stromal cell in the thymic cortex . | tissue_is_expression_site_of_gene_product | {
"id": "C0039215",
"name": "positive",
"pos": [
0,
8
]
} | {
"id": "C0019630",
"name": "mhc class ii",
"pos": [
47,
59
]
} |
classical t lymphocytes recognize foreign antigens in the context of self major histocompatibility complex ( mhc ) molecules by means of the t-cell receptor ( tcr ) alpha beta heterodimer . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
10,
23
]
} | {
"id": "C0085247",
"name": "t-cell receptor",
"pos": [
141,
156
]
} |
in order to elucidate the developmental pathways of class ii mhc-restricted t cells in relation to these essential accessory molecules , we have produced tcr-transgenic mice expressing a receptor specific for a fragment of pigeon cytochrome c and the ek ( class ii mhc ) molecule . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
76,
83
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
154,
157
]
} |
in addition , the peripheral t-cell population is almost exclusively cd4+ , demonstrating that the mhc specificity of the tcr determines the phenotype of t cells during selection in the thymus . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t-cell",
"pos": [
29,
35
]
} | {
"id": "C0034790",
"name": "tcr",
"pos": [
122,
125
]
} |
alloreactive t cells also show specificity for mhc molecules , and various reports suggest that residues of the mhc molecules constitute at least part of the ligand to which alloreactive t-cell receptors bind . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
13,
20
]
} | {
"id": "C0034790",
"name": "t-cell receptors",
"pos": [
187,
203
]
} |
sex differences in the hypothalamic control of growth hormone ( gh ) secretion were investigated by measuring rat gh-releasing factor ( rgrf ) and somatostatin in male and female rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
23,
35
]
} | {
"id": "C0037668",
"name": "gh-releasing factor",
"pos": [
114,
133
]
} |
sex differences in the hypothalamic control of growth hormone ( gh ) secretion were investigated by measuring rat gh-releasing factor ( rgrf ) and somatostatin in male and female rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
23,
35
]
} | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
147,
159
]
} |
whole hypothalamic rgrf-ir and sli contents were influenced only moderately by adult gonadectomy or gonadal steroid treatments . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
6,
18
]
} | {
"id": "C0023610",
"name": "rgrf-ir",
"pos": [
19,
26
]
} |
practically all animals from this strain show severe lymphoid infiltration of the thyroid gland and circulating autoantibodies against thyroglobulin ( tg-aab ) within a few weeks after hatching . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid gland",
"pos": [
82,
95
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
135,
148
]
} |
red cells were modelled as discrete hemoglobin ( hb ) containing spheres flowing in single file suspension through a cylindrical capillary surrounded by a uniform annulus of alveolar tissue . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cells",
"pos": [
0,
9
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
36,
46
]
} |
excised rabbit lungs were perfused either with washed human red cell suspensions or with hemoglobin solutions , each with 50 g hemoglobin/l , and steady-state diffusing capacities ( dlo2 ) for oxygen elimination measured . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
60,
68
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
127,
137
]
} |
the release of prolactin is regulated by a dual hypothalamic control system , the prolactin-release-inhibiting factor and the prolactin-releasing factor . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
48,
60
]
} | {
"id": "C0023610",
"name": "prolactin-releasing factor",
"pos": [
126,
152
]
} |
in the normal appendices , there was a strong staining of the endothelial cells for t-pa , whereas there was negative staining for u-pa . | tissue_is_expression_site_of_gene_product | {
"id": "C0225336",
"name": "endothelial cells",
"pos": [
62,
79
]
} | {
"id": "C0042071",
"name": "u-pa",
"pos": [
131,
135
]
} |
a number of microorganisms produce toxins with mitogenic potential for t cells of many species , and in this article bernhard fleischer discusses how these toxins may be useful tools to improve understanding of the structure and function of the t-cell antigen receptor . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
71,
78
]
} | {
"id": "C0034790",
"name": "t-cell antigen receptor",
"pos": [
245,
268
]
} |
cysteamine ( 1.95 or 3.90 mm/kg ) decreased the somatostatin levels both in the hypothalamus and in the striatum without influencing neuropeptide y ( npy ) and corticotropin releasing hormone ( crh ) concentrations . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
80,
92
]
} | {
"id": "C0010132",
"name": "corticotropin releasing hormone",
"pos": [
160,
191
]
} |
studies on the release of follicle-stimulating hormone in vitro from rat pituitary glands stimulated by hypothalamic follicle-stimulating hormone-releasing factor . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
104,
116
]
} | {
"id": "C0023610",
"name": "follicle-stimulating",
"pos": [
117,
137
]
} |
these findings indicate that the liver is a source of the globulin and that appearance of this protein in the serum results from de novo synthesis by the liver rather than from release of performed and stored globulin . | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
33,
38
]
} | {
"id": "C0017649",
"name": "globulin",
"pos": [
209,
217
]
} |
determinations of red cell and hemoglobin mass after three and six months and monthly determinations of hemoglobin concentration , packed cell volume , red cell count , reticulocyte count , mean corpuscular volume and mean corpuscular hemoglobin concentration showed no significant rise in either the men or the women . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "red cell",
"pos": [
18,
26
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
235,
245
]
} |
hypothalamic growth hormone releasing factor : release and synthesis after exposure to a high ambient temperature . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
0,
12
]
} | {
"id": "C0037668",
"name": "growth hormone releasing factor",
"pos": [
13,
44
]
} |
it is suggested that erythrocytic vasoconstrictive effect may be due to both hemoglobin and erythrocyte membrane proteins . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocytic",
"pos": [
21,
33
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
77,
87
]
} |
as vascular perfusion of islet cells is normally b to a to d , these results suggest that neither intra-islet hormone interactions nor intra-pancreatic insulin or glucagon sensitive nerve feedback systems are responsible , on an acute basis , for the regulation of pulsatile insular secretion from the normal pancreas . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet",
"pos": [
25,
30
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
152,
159
]
} |
the pluripotent rat islet tumor cell line msl-g2 expresses primarily glucagon or cholecystokinin and not insulin in vitro but changes phenotype completely after prolonged in vivo cultivation to yield small-sized hypoglycemic tumors composed almost entirely of insulin-producing beta cells . | tissue_is_expression_site_of_gene_product | {
"id": "C0022131",
"name": "islet",
"pos": [
20,
25
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
260,
267
]
} |
the results show significant changes in some of the basic hemostatic indices : decreased antithrombin iii activity , increased alpha 2-macroglobulin and plasminogen activity , partial thromboplastin time shortening , increased erythrocyte , hemoglobin and hematocrit values . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "erythrocyte",
"pos": [
227,
238
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
241,
251
]
} |
the aim of the present study was to test the hypothesis that the restoring effect of testosterone on hypothalamic gnrh stores in orchidectomized rats might be linked to the intrahypothalamic transformation of the hormone into estrogenic metabolites . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
101,
113
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
114,
118
]
} |
the animals were sacrificed 24 h after the last injection , and hypothalamic gnrh content was measured by radioimmunoassay . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
64,
76
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
77,
81
]
} |
the results have confirmed the ability of tp to counteract the decreasing effect of orchidectomy on hypothalamic gnrh stores , and have shown that tmx does not have any intrinsic activity on this parameter . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
100,
112
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
113,
117
]
} |
it is concluded that the action of testosterone on hypothalamic gnrh does not require the conversion of the hormone into estrogens . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
51,
63
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
64,
68
]
} |
carnitine infusion did not significantly affect nitrogen balance , protein content of liver and muscle , plasma concentrations of bcaa and branched-chain keto acid , or leucine oxidation and incorporation into liver and muscle proteins of either starved or fed rats . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
96,
102
]
} | {
"id": "C0026832",
"name": "muscle proteins",
"pos": [
220,
235
]
} |
anti-lymphocyte globulin stimulates normal human t cells to proliferate and to release lymphokines in vitro . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocyte",
"pos": [
5,
15
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
87,
98
]
} |
decidualising stromal cells also produce basement membrane components ( type iv-collagen , laminin , heparan sulphate proteoglycan and a glycoprotein family recognised by monoclonal antibody g71 ) and these become organised into a pericellular aura . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
41,
58
]
} | {
"id": "C0009333",
"name": "type iv-collagen",
"pos": [
72,
88
]
} |
this paper reports a rare primary prostatic adenocarcinoid tumor confirmed by electron microscopy as well as immunohistochemical method including prostate specific antigen and prostatic acid phosphatase . | tissue_is_expression_site_of_gene_product | {
"id": "C0033572",
"name": "prostatic",
"pos": [
34,
43
]
} | {
"id": "C0138741",
"name": "prostate",
"pos": [
146,
154
]
} |
transcripts of this gene , which were demonstrated to encode a basement membrane type iv collagen chain , began to accumulate specifically in mesodermal derivatives at stages 12-13 of embryogenesis , and not before . | tissue_is_expression_site_of_gene_product | {
"id": "C0004799",
"name": "basement membrane",
"pos": [
63,
80
]
} | {
"id": "C0009333",
"name": "type iv collagen",
"pos": [
81,
97
]
} |
previously published studies have consistently shown elevations of gnrh content in the preoptic area ( poa ) and hypothalamus starting with the appearance of gnrh immunoreactivity around fetal day 12-14 until stabilization around the time of puberty . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
113,
125
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
158,
162
]
} |
in fast muscles of the mutant , in-vitro-translatable parvalbumin mrna was strongly reduced , whereas the mrna for the slow-muscle-specific protein , p19/6.8 , was increased . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscles",
"pos": [
8,
15
]
} | {
"id": "C0026832",
"name": "muscle",
"pos": [
124,
130
]
} |
previously , we have shown that paraformaldehyde-fixed monocytes are able to fully complement , in terms of [ 3h ] dthd incorporation , a primary stimulus delivered to purified t cells by monoclonal antibodies ( mab ) reacting with cd3 or cd2 molecules . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
177,
184
]
} | {
"id": "C0108773",
"name": "cd2 molecules",
"pos": [
239,
252
]
} |
conjugate formation of activated lfa-1- t lymphocytes was mostly mediated by the cd2-lfa-3 adhesion pathway while the icam-1 molecule , a ligand of lfa-1 , had no function . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t lymphocytes",
"pos": [
40,
53
]
} | {
"id": "C0063695",
"name": "icam-1",
"pos": [
118,
124
]
} |
the examination items were as follows : red blood cell count ( rbc ) , hematocrit value ( ht ) , hemoglobin concentration ( hb ) , mean corpuscular volume ( mcv ) , white blood cell count ( wbc ) , total protein ( tp ) , albumin ( alb ) , glucose ( glu ) , total cholesterol ( tcho ) , free cholesterol ( fcho ) , triglyceride ( tg ) , and albumin-globulin ratio ( a/g ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
63,
66
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
124,
126
]
} |
rbc , ht and hb decreased in the last of the four periods of pregnancy ( group iv ) . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
0,
3
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
13,
15
]
} |
judging from the relative eigenvector value of each variable for the first canonical variate , the effective discriminant variables were rbc , ht , hb , mcv , tp and a/g . | tissue_is_expression_site_of_gene_product | {
"id": "C0014792",
"name": "rbc",
"pos": [
137,
140
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
148,
150
]
} |
these data show that all hepatocytes in the adult liver express a small number of alpha-fetoprotein mrna sequences ; | tissue_is_expression_site_of_gene_product | {
"id": "C0023884",
"name": "liver",
"pos": [
50,
55
]
} | {
"id": "C0002210",
"name": "alpha-fetoprotein",
"pos": [
82,
99
]
} |
using this assay system , chloramphenicol acetyltransferase activity directed by the ctnt promoter/upstream region was between two and three orders of magnitude higher in cardiac or skeletal muscle cells than in fibroblast cells , indicating that cis elements responsible for cell-specific expression reside in this region of the ctnt gene . | tissue_is_expression_site_of_gene_product | {
"id": "C0018787",
"name": "cardiac",
"pos": [
171,
178
]
} | {
"id": "C3538889",
"name": "ctnt",
"pos": [
330,
334
]
} |
an arterial blood supply to a region of the anterior pituitary could result in the escape of that area from hypothalamic regulation , since systemic blood contains negligible levels of hypothalamic hormones . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
108,
120
]
} | {
"id": "C0020656",
"name": "hypothalamic hormones",
"pos": [
185,
206
]
} |
to examine whether the hypothalamic corticotropin-releasing hormone ( crh ) neuron is regulated by crh , by products of the proopiomelanocortin ( pomc ) gene , and/or by glucocorticoids , we used a rat hypothalamic organ culture system in which rat crh secretion from single explanted hypothalami was evaluated by an ria ( icrh ) specific for rat crh . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalami",
"pos": [
23,
34
]
} | {
"id": "C0010132",
"name": "crh",
"pos": [
347,
350
]
} |
differential effects of hypothalamic catecholamine depletion on the release of arginine vasopressin and crf-41 into hypothalamo-hypophyseal portal blood . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
24,
36
]
} | {
"id": "C0010132",
"name": "crf-41",
"pos": [
104,
110
]
} |
within this framework all hormones of the limbic-hypothalamic- pituitary-adrenocortical ( lhpa ) -axis play a dominant role , because : ( 1 ) corticotropin-releasing hormone ( crh ) was shown to integrate centrally behavioral and metabolic responses to stress ; | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "lhpa",
"pos": [
90,
94
]
} | {
"id": "C0010132",
"name": "corticotropin-releasing hormone",
"pos": [
142,
173
]
} |
the results suggest that the isolated rat hypothalamus is extremely sensitive to the level of glucose and that crf is rapidly and reversibly secreted in response to slight reductions in glucose concentrations . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamus",
"pos": [
42,
54
]
} | {
"id": "C0010132",
"name": "crf",
"pos": [
111,
114
]
} |
the n-terminal amino acid sequences of the hemopexins purified from the plasma of rat , rabbit and chicken were compared with each other and with that of human hemopexin . | tissue_is_expression_site_of_gene_product | {
"id": "C0032105",
"name": "plasma",
"pos": [
72,
78
]
} | {
"id": "C0019067",
"name": "hemopexin",
"pos": [
160,
169
]
} |
( 2 ) the use of rejuvenated erythrocytes had no significant effect on concentrations of muscle atp , phosphocreatine and lactate , nor fractional rates of muscle protein synthesis . | tissue_is_expression_site_of_gene_product | {
"id": "C0026845",
"name": "muscle",
"pos": [
89,
95
]
} | {
"id": "C0026832",
"name": "muscle protein",
"pos": [
156,
170
]
} |
the evidence that hypothalamic gonadotropin-releasing hormone ( gnrh ) release increases during the estrogen-induced luteinizing hormone ( lh ) surge in castrated female macaques and that estrogen induces a similar lh surge in the male suggests that either sexual differentiation of gnrh secretion does not exist or that changes in brain gnrh are not critical for ovulation . | tissue_is_expression_site_of_gene_product | {
"id": "C0020663",
"name": "hypothalamic",
"pos": [
18,
30
]
} | {
"id": "C0023610",
"name": "gnrh",
"pos": [
338,
342
]
} |
kinase c-depleted t cells showed no induction of mrnas for activation-associated genes on exposure to the t cell receptor ligand concanavalin a ; | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
18,
25
]
} | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
106,
121
]
} |
thus , t cell dual recognition results from the cross-reactive recognition of an allo-mhc product by a single antigen-specific and mhc-restricted alpha beta t cell receptor . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cell",
"pos": [
7,
13
]
} | {
"id": "C0085247",
"name": "alpha beta t cell receptor",
"pos": [
146,
172
]
} |
the failure of coding joint formation in scid pre-b and pre-t cells appears sufficient to explain the absence of immunoglobulin or t cell receptor production in scid mice . | tissue_is_expression_site_of_gene_product | {
"id": "C0039194",
"name": "t cells",
"pos": [
60,
67
]
} | {
"id": "C0034790",
"name": "t cell receptor",
"pos": [
131,
146
]
} |
the recruitment of lymphocytes into the skin by t cell lymphokines : the role of gamma-interferon . | tissue_is_expression_site_of_gene_product | {
"id": "C0024264",
"name": "lymphocytes",
"pos": [
19,
30
]
} | {
"id": "C0024297",
"name": "lymphokines",
"pos": [
55,
66
]
} |
thyroid microsomal and/or thyroglobulin antibody titers were elevated to a level diagnostic of hashimoto 's disease ( greater than 1:400 ) in 25 ( 48 % ) patients with turner 's syndrome . | tissue_is_expression_site_of_gene_product | {
"id": "C0040132",
"name": "thyroid",
"pos": [
0,
7
]
} | {
"id": "C0040123",
"name": "thyroglobulin",
"pos": [
26,
39
]
} |
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