anchor
large_stringlengths
18
1.31k
positive
large_stringlengths
0
284
class
class label
3 classes
The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.
nuclear mRNA degradation
0biological_process
Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.
mitochondrial RNA 5\' end processing
0biological_process
Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion.
mitochondrial RNA 3\' end processing
0biological_process
Any process involved in forming the mature 5' end of an RNA molecule.
RNA 5\' end processing
0biological_process
Any process involved in forming the mature 5' end of an rRNA molecule.
rRNA 5\' end processing
0biological_process
Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
bacterial-type RNA polymerase regulatory region DNA binding
2molecular_function
Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
bacterial-type RNA polymerase transcription regulatory region sequence-specific DNA binding
2molecular_function
Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
eubacterial-type RNA polymerase regulatory region DNA binding
2molecular_function
Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
eubacterial-type RNA polymerase regulatory region sequence-specific DNA binding
2molecular_function
Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
regulatory region DNA binding
2molecular_function
Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
transcription regulatory region DNA binding
2molecular_function
Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
transcription regulatory region sequence-specific DNA binding
2molecular_function
Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
RNA polymerase II regulatory region DNA binding
2molecular_function
Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II core promoter proximal region sequence-specific DNA binding
2molecular_function
Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II distal enhancer sequence-specific DNA binding
2molecular_function
Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II promoter proximal region sequence-specific DNA binding
2molecular_function
Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II proximal promoter sequence-specific DNA binding
2molecular_function
Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.
RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II transcription factor activity, copper ion regulated core promoter proximal region sequence-specific binding
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II transcription factor activity, copper ion regulated proximal promoter sequence-specific DNA binding
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II transcription factor activity, metal ion regulated proximal promoter sequence-specific DNA binding
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II transcription factor activity, metal ion regulated sequence-specific DNA binding
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II transcription factor activity, sequence-specific DNA binding
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II transcription factor activity, zinc ion regulated core promoter proximal region sequence-specific DNA binding
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II transcription factor activity, zinc ion regulated proximal promoter sequence-specific DNA binding
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
sequence-specific distal enhancer binding RNA polymerase II transcription factor activity
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
sequence-specific DNA binding RNA polymerase II transcription factor activity
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
transcription factor
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
2molecular_function
A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity
2molecular_function
Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
bacterial-type cis-regulatory region sequence-specific DNA binding
2molecular_function
Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
bacterial-type proximal promoter sequence-specific DNA binding
2molecular_function
Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding
2molecular_function
Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
bacterial-type RNA polymerase enhancer sequence-specific DNA binding
2molecular_function
Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
bacterial-type RNA polymerase upstream activating sequence (UAS) sequence-specific DNA binding
2molecular_function
Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
cis-regulatory region binding
2molecular_function
Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
core promoter proximal region DNA binding
2molecular_function
Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
core promoter proximal region sequence-specific DNA binding
2molecular_function
Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
enhancer binding
2molecular_function
Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
enhancer sequence-specific DNA binding
2molecular_function
Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
eubacterial-type RNA polymerase regulatory transcription factor sequence-specific DNA binding
2molecular_function
Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
promoter proximal region sequence-specific DNA binding
2molecular_function
Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers.
proximal promoter sequence-specific DNA binding
2molecular_function
Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.
RNA polymerase II core binding
2molecular_function
Binding to an RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.
RNAP II core binding
2molecular_function
Binding to a bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit.
eubacterial-type RNA polymerase core enzyme binding
2molecular_function
Binding to a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
RNA polymerase III regulatory region DNA binding
2molecular_function
Binding to an RNA polymerase III transcription factor, a protein required to initiate or regulate transcription by RNA polymerase III.
RNA polymerase III transcription factor binding
2molecular_function
Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
bacterial-type RNA polymerase core promoter sequence-specific DNA binding
2molecular_function
Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
core promoter binding
2molecular_function
Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
eubacterial-type RNA polymerase core promoter sequence-specific DNA binding
2molecular_function
Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.
SP6-type RNA polymerase binding
2molecular_function
Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.
T3-type RNA polymerase binding
2molecular_function
Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.
T3/T7 type RNA polymerase binding
2molecular_function
Binding to a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6.
T7-type RNA polymerase binding
2molecular_function
The synthesis of RNA from a DNA template by RNA polymerase V, originating at a Pol V-specific promoter.
transcription from RNA pol V promoter
0biological_process
The synthesis of RNA from a DNA template by RNA polymerase V, originating at a Pol V-specific promoter.
transcription from RNA polymerase V promoter
0biological_process
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
T3/T7 type RNA polymerase activity
2molecular_function
Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair.
regulatory region nucleic acid binding
2molecular_function
A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.
regulation of transcription from RNA polymerase II promoter by nitrogen catabolites
0biological_process
Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.
RNA polymerase II basal transcription factor binding
2molecular_function
Binding to a component of the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase.
basal RNAP II transcription machinery binding
2molecular_function
Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).
down regulation of exit from mitosis
0biological_process
Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).
down-regulation of exit from mitosis
0biological_process
Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).
downregulation of exit from mitosis
0biological_process
Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).
inhibition of exit from mitosis
0biological_process
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
response to acid
0biological_process
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
response to acid anion
0biological_process
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.
response to oxoanion
0biological_process
Any process involved in the transition from the initiation to the elongation phases of transcription by a DNA-dependent RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.
promoter clearance during DNA-dependent transcription
0biological_process
Any process involved in the transition from the initiation to the elongation phases of transcription by a DNA-dependent RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.
promoter clearance from bacterial-type RNA polymerase promoter
0biological_process
Any process involved in the transition from the initiation to the elongation phases of transcription by a DNA-dependent RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.
promoter escape
0biological_process
A process that mediates the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.
promoter clearance from RNA polymerase II promoter
0biological_process
A process that mediates the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.
promoter escape from RNA polymerase II promoter
0biological_process
A process that mediates the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors.
promoter-paused RNA polymerase II release
0biological_process
Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
DNA-dependent transcriptional open complex formation
0biological_process
Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
DNA-templated transcriptional open complex formation
0biological_process
Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
promoter melting
0biological_process
Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
transcription open complex formation at bacterial-type RNA polymerase promoter
0biological_process
Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
transcriptional open complex formation at bacterial-type RNA polymerase promoter
0biological_process
Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
RNA polymerase II promoter melting
0biological_process
Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble.
transcriptional open complex formation at RNA polymerase II promoter
0biological_process
Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA-RNA complex.
protein-DNA-RNA complex subunit organisation
0biological_process
The acquisition, loss, or modification of macromolecules within a protein-DNA complex, resulting in the alteration of an existing complex.
protein-DNA complex remodelling
0biological_process
Binding to an intronic DNA sequence that regulates the transcription of the transcript it is contained within.
intronic transcription regulatory region DNA binding
2molecular_function
Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I.
RNA polymerase I regulatory region DNA binding
2molecular_function
The synthesis of an RNA transcript from an RNA template.
transcription, RNA-dependent
0biological_process
The synthesis of an RNA transcript from an RNA template.
transcription, RNA-templated
0biological_process
Any process involved in the selection of the specific location within the template strand of a DNA-dependent RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
DNA-dependent transcriptional start site selection
0biological_process
Any process involved in the selection of the specific location within the template strand of a DNA-dependent RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript.
transcriptional start site selection at bacterial-type RNA polymerase promoter
0biological_process