title
stringlengths 1
300
| content
stringlengths 1
39k
⌀ | score
int64 0
6.38k
|
|---|---|---|
Ashwaganda
|
Had anyone taken ashwaganda and actually felt worse? I added it to my combo of pills and felt dreadful, like semi suicidal…. Anyone else?
| 2 |
Imipramine vs nortriptyline
|
Hi looking for experiences on both and what are the main differences.
I was on 75 mg nortriptyline but anxiety was unbearable
Wondering if imipramine would be less noradrergenic
Thanks
| 2 |
LionsMane for Depression?
|
So guys i struggle with depression and some months ago i've decided to take off my medication (sertraline), it went "fine", very little side effects. But now i think i'm relapsing and i'm thinking to go back with the medication.
It's total anectodal, but today i've found one last lions (the mushroom) mane pill from the bottle, and i think my mood and brain fog today slightly improved.
I've bought this lions mane pack with 90 pills and i was taking last year along with sertraline, because im pissed of how my memory and concentration suck because of the illness, i was taking to help with that, and i think i havent had bad reactions with the combination of the two.
Idk there are so many contradictory comments about this product, some people saying it has caused horrible reactions etc, some saying its good.
Does anyone of you have experiences with lions mane lifting your depression? My experince today could be totally random or placebo even, but it made me think to try to take lionsmane every day to see if theres a positive change before i decide to go back to an antidepressant, what you guys think?
\*I was taking 1g, in pills
| 9 |
Antidepressant (vortioxetine) - reducing dosage flexibility
|
I have been taking Trintelllix (Vortioxetine) for over a year. Initially I was on a 3-part program of Step 1 take 5 mg for 2 weeks then step 2 take 10 mg for 2 weeks, then Step 3 15 mg every day. And it worked very well, I stopped crying for no reason etc.
Last month after talking to my doctor telling him I feel even better and wondering if I still need the full dosage, he updated my instructions. According to "how I feel", no more frequently than once every 2 weeks, I can reduce/increase by 5 mg at a time, until I find my "ideal" dosage and then stick to the dosage that makes sure that I won't have to re-up the dose right after having reducing it (no going yo-yo every 2 weeks with that thing).
So far, I'm down to 10 mg for a month, so far so good. Main benefit is that I don't feel "artificially slightly extra peppy" anymore, which can be both seen as an upside or a downside or both. But I feel ready to follow my doctor instructions and to reduce to 5 mg.
Things look like I will end up with a lot of leftover 10 mg pills. And I really hate to waste. Plus, those pills are COSTLY (nearly 3$ each \*after\* insurance paid 2/3 of the total cost). And I already paid for them anyway and, like most people, I'm not made of gold.
So my question is this:
Given that the doctor told me taking two 5 mg pills is the exact same as taking a single 10 mg pill...
​
A - Could I take a 10 mg pill every 2 days instead, without it affecting my potential mood "variation" too much? Remember that I am currently ALREADY at 10 mg anyway. I could also probably synch most of the "no pills" days so that they fall during less stressful days.
​
B - Could I instead just cut the (already tiny) pills in 2 halves, and just make sure the two halves always get taken in consecutive days, so that even if the halves if they are not \*exactly\* equal, over the 2 days I'd still get exactly 10 mg, anbd on each day I'd get "more or less" 5 mg.
​
C - Avoid doing that kind of money saving tricks at all costs, otherwise somehow my head will magically just go KABLOOEY because reasons unknown.
​
I also don't mind if my mood varies a \*bit\*. Heck, I often forgot to take my pills (\*all\* my pills, mind you, not just the antidepressants ) and never noticed any "short term" effects on my mood.
Just that early on, the pills helped a LOT but it took a few weeks, and after a year at 15 mg, I tended too often to feel "a bit too artificially happy", but those are long term effect. Not a "you forgot your pill in the morning, so you're definitely going to cry a lot in the evening".
So, which would be better?
Or does it even make real any difference?
If I can use my 10 mg pills I'd save about a 100$ worth of pills, so it's worth a lot to me.
Heck from now on if I need to dose to be at 5 mg I'd shut my mouth and stick to buying only the 10 mg pills, and use either 5 mg per day or 1 10 mg pill every per 2 days, so that overall I would save half. that is because the 5 mg box and the 10 mg box are both at about the same price!!! It is so obvious that this is a nice pharmaceutical corporate scam is going on here to make undue profits off of depressives!!!
​
Thank you so much for your help!
| 5 |
wellbutrin questions
|
how common is hair loss and tinnitus from this med?
also what do you use to sleep?
| 3 |
what can i do to stop my brain from making everything some thing about guilt or shame?
|
this sub seems very medication focused but is probably one of the only active subs i see for depression. please let me know if it's not related, i'll try to keep it as related to treatment as possible.
what can i do to stop spinning everything into something related to shame?
i am currently taking wellbutrin 300mg, before that with lexapro (20mg?) and even with the ssri i felt this, and continue to feel it on an increasing level. i try to redirect my negative thoughts for years, but it just doesn't work.
quite literally anything is associated with shame and stress and it's getting tiring.. i've been trying to cut down my social media so i have more time for walking, mediation, etc.
one simple example would be not drawing because i feel shame for how much i've let the skill go, where the skill could be if i practiced, and how many people literally my age or younger are animators at pixar, something that was only a dream of mine when i was a young artist, and planned to pursue post-bachelors before i failed the major i wanted and fell into depression.
another example, i didn't put a social media limit on tiktok because i used to enjoy it at some point and want to encourage myself to enjoy it again. but some feeling of shame is somehow associated. here it would be: not being up to date on what people my age are doing, and wanting to participate in the trends but never having the energy, and then feeling guilty, when several years ago, i made funny videos without a second thought–– for fun. and now i'm getting older and older.
with music i used to dance and sing to, now i don't, i barely have the energy to memorize the lyrics. it's not that i'm bored of the music; new music somehow leads to some feeling of shame.
what do i do here? do i just keep telling myself "don't be hard on yourself"? what does a depressed brain do when it is literally wired at its core to be hard on itself–– just don't be yourself?
| 24 |
How long till doxepin stops affecting me?
|
Hello. 2 weeks ago I got started on doxepin for anxiety and depression. However I first started having effects from it since the weekend, and the only effect I feel is intense dizziness, as if my whole system was shutting down any time I'd stood up or lay down and still pretty intense even when not changing my body's position. So I stopped taking it, last time I took it was monday evening, so 43 hours ago. However I am still pretty dizzy, I'm wondering when this will stop as I had to call in sick to work because of it.
I appreciate all answers, thank you very much.
| 2 |
Rexulti weight gain?
|
Is gaining 9 lbs in 35 days on rexulti possible?
I just lost 25 lbs over 10 months (while on Abilify & when starting metformin). Then held steady at 180lbs for about 3 months...
Switched Abilify to Rexulti and I'm steadily gaining. Could it actually be Rexulti?
| 5 |
First Dr. Appt tomorrow in a long time. Advice appreciated.
|
Set up a new primary care physician with help of my therapist to finally tackle anxiety and depression and start taking some meds. I am nervous and just wanted to vent about it a little. I hate the Dr's office, but I am getting older and know I need to take these necessary steps to better my mental health.
One of my biggest issues is just a complete lack of motivation to accomplish anything. Have anti-depressants or anti-anxiety medications helped anyone with this particular issue? I just want to feel like a productive human again. I don't want messes to pile up, I want to do better work at my job, and I want to get on a normal schedule of working out and eating healthy.
I know that meds aren't a cure-all and that I need to, and have with help of therapy, made changes to my routine. Is there any advice you can give me to calm me down or questions to ask my new doctor, or certain things to let them know about? Thanks. :)
| 5 |
Academic Study on Depression (18+, International, Past experiences with depression)
|
Hi everyone,
This may not apply to many folks on here, but I figured I'd give it a shot anyway. I am currently looking to recruit participants to complete my online research study that is part of my dissertation in clinical psychology. My research focuses on understanding the concept of Fear of Depression Recurrence, which captures fears that people who are remitted from depression may have about becoming depressed again. The goal of this online study is to gain a better understanding of the construct and validate the psychometric properties of a Fear of Depression Recurrence questionnaire. We hope that learning more about fear of depression recurrence may present a small window into understanding depression relapse and thus lead to better informed prevention efforts.
**Interested? Here is some more information about the study:**
***Were you ever diagnosed with depression? Do you feel better now?***
The ***Stress and Developmental Psychopathology Laboratory*** at Concordia University is currently recruiting English-speaking participants for a study investigating the potential fears that people who are no longer depressed may have about their depression returning. This ethically approved study involves completing online questionnaires that assess the fears you may have about your depression returning, as well as the severity, frequency, content, and triggers of these fears. It will also ask you for basic personal information (e.g., age, gender, race/ethnicity, occupation) and questions about your current depressive symptoms, other mental health concerns, beliefs about depression, coping strategies, and quality of life.
The online survey will take approximately **1 hour** to complete. All components of this study can be completed remotely, in the comfort of your own home.
Participants who are eligible and complete our online survey will be entered in a draw to win one of **seven** $100 CAD Amazon Gift cards.
**If you are interested and you:**
✔ Are above the age of 18
✔ Have previously experienced an episode of depression
✔ Have no significant symptoms of depression during the last 2 months
Please click on the following link which will bring you to our pre-screening questionnaire to determine your eligibility. If eligible, you will be able to access our consent form and the online survey from this same link.
**Survey Link:** [https://concordiaccrh.qualtrics.com/jfe/form/SV\_8v5TiIGO7rSk5kG](https://concordiaccrh.qualtrics.com/jfe/form/SV_8v5TiIGO7rSk5kG)
| 3 |
My anxiety is getting out of hand
|
I feel ANXIOUS, depressed, I keep getting psychosomatic symptoms of panic and I am so tired. I am on medication (amitriptyline 10mg, perphenazine 4mg, mirtazapine 45mg) and I still feel so bad. I don't wanna end up at the hospital again or get addicted to benzos but I simply don't know what to do. Every single thing triggers my PTSD (I am diagnosed with SAD, PTSD, OCD and Panic Disorder). I am gonna try getting in contact with my psychiatrist but I'm struggling so much to be patient till I see him.
| 10 |
When you get overwhelming sadness no matter when you do that’s positive that can change it what can you actually do that’ll stop the random overwhelming dread/tears that keep you from enjoying your life
| null | 15 |
Assessing the Appropriateness of Changing Dosage and Prescribing a New Antidepressant
|
Is it appropriate for my therapist to change my dosage of paroxetine (Paxil) from 25 to 12.5 for 7 days and subsequently prescribe a new antidepressant, Prozac, after having prescribed paroxetine for nearly 2 months?
| 2 |
Tryciclic list from more to less activating
|
Hi all,
I was on 75 mgs nortryptiline for a few months but it made my anxiety sky rocketing
What would be the more activating ones / anxiety messers and the less ones
Also side effects wise
Thanks
| 2 |
Has anyone here successfully been prescribed Buprenorphine or Ketamine specifically for Depression?
|
Both drugs have shown a lot of promise in literature in helping hard-to-treat depression.
Problem 1: both drugs have addictive potential. Not as much as say Ritalin or Opioids, but it's there, so that's a concern.
Problem 2: their efficacy in depression at this stage is academic only (with the exception being S-Ketamine, although literature states that the R-isomer, or Ketamine HCL itself, is also beneficial)
For the record, has anyone here successfully been prescribed either drug specifically to deal with Depression, under the care of a doctor?
| 8 |
What have you taken that has given you more instant relief for the whammies of depression, adhd, social anxiety, anxiety in general, motivation issues, etc
| null | 23 |
Hydroxyzine and St John Wort, how big is the interaction
|
Read about an interction, but how big is it, will 25mg feel like 12mg or does it negate completely. Google gives me so few hits when searching.
| 1 |
Is there anything to boost/improve Antidepressant work
|
Im using Paxil 20mg
So maybe like magnesium, Zinc, omega 3 or something like that?
| 10 |
Do you ever get THOSE days where everything just turns black for some odd reason?
|
At 34, after 14 long years of trial and error, I feel I've finally hit a point where my treatment is really starting to hit the mark.
That said, I still get the occasional 'odd' day where those damn demons enter my head again and make me feel completely defeated.
For instance, yesterday I had an extremely productive day; yet this morning I was (I can't believe I'm saying this) researching active ways to end my life through messing up my carotid artery.
My usual saving grace is: "Suicide never has to be a rush decision. You always have time to do it later. Much later." - that quote alone is probably what saves my ass when things go unusually dark.
It's so weird. I'm making huge progress with my treatment. Better than ever before actually. Yet still for some confusing reason, I get these odd days where the black dog still manages to bite me. {"Black dog" was coined by Winston Churchill who suffered frequent bouts of crippling depression.}
Anyone else have odd moments like this despite being in treatment?
PS. It isn't Bipolar. That's been officially ruled out by several psychiatrists over many years of close observation.
PPS. Don't worry. I'm not at risk. I'm merely demonstrating how these bizarre passing thoughts can randomly wash over you sometimes for no clear reason. Good thing is that with treatment, the 'storm', if you will, lasts about 15 minutes max for me now, whereas before treatment it was more like 12 hours a day. If anything, simply knowing that I have 'that option', if it ever really comes to it, that's enough to give me comfort.
| 39 |
I tried everything for chronic depression: I think I am left with TMS, ECT and esketamine. Advice?
|
The title say it all.
Since 16 yo, I am 48 now, I had depression occasionally stronger, occasionally milder but enough to slow me down in my studies, compromise relationships and create problems at work.
I tried all the ADs available. Right now I am on Parnate 40 md/day.
Pdoc is recommending ECT. I fear it might mess with my memory and cognition long term or permanently so I have said no so far but I feel that I am running out of options. Perhaps esketamine or TMS could help?
What do you advice? Has people tried ECT here? How was it?
| 27 |
Difference between withdrawal and post withdrawal syndrome
|
When I stopped Zoloft three months ago I did not really experience brain zaps or more anxiety, I was not doing good but it was still manageable. Now all of a sudden I have this really bad anxiety, fatigue and depression even though I have a passion to do the things I used to do and I don't understand what is going on
| 5 |
Rather than beat yourself up, let this be the image of your enemy - the Black Shuck
|
Winston Churchill described his frequent bouts of depression as getting bitten hard by a black dog.
So let's get an image of the scariest, nastiest black dog ever conceived in historic legend: the Black Shuck.
[latest (752×641) (nocookie.net)](https://static.wikia.nocookie.net/mythology/images/f/fd/Blackshuck1.jpg/revision/latest?cb=20191114215554)
Let this image be the face of your enemy. Not yourself. Whenever the despair, the sadness, the anger.. all becomes too much, remember to look at this face and remember this is the face of your enemy. And you must beat him, no matter what.
| 9 |
All new anxiety and depression I have not experienced before post withdrawal?
|
When I stopped Zoloft three months ago I did not really feel that much different than I was currently feeling. Of course things became worse but I never had brain zaps, nausea or anxiety. It was only until now that I started experiencing very bad anxiety, depression and fatigue that I had never experienced before and I don't know what to call it.
Is it possible to not experience much withdrawal initially but have new worsening symptoms months later? Have read this is called Post withdrawal syndrome but cannot find much on it. Also would tapering affect Post withdrawal syndrome?
| 1 |
What are augmentation options for OCD with Selegiline (Emsam)?
| null | 2 |
Quotes that I actually found helpful when all is hopeless, and I'm unable to reach out to others
|
“The epic story of tomorrow can't be written if it ends today.”
“To write poetry and to commit suicide, apparently so contradictory, had really been the same, attempts at escape.”
“Though no one can go back and make a brand new start, anyone can start now and make a brand new ending.”
“Anyone desperate enough for suicide should be desperate enough to go to creative extremes to solve problems: elope at midnight, stow away on the boat to New Zealand and start over, do what they always wanted to do but were afraid to try.”
“You may not understand today or tomorrow, but eventually God will reveal why you went through everything you did.”
“Don’t give up. You've still got a couple of people to prove wrong.”
“If you're going through hell, keep going. The exit is there.”
"Today will end with tomorrow's beginning. And no one knows the hope tomorrow brings."
"When you want to give up on today, remember the strength you used to get through yesterday, and the new possibilities tomorrow brings."
"Every step forward on the darkest path is one step closer to finding the light switch."
"When this breath is begging to be your last, remember the millions of breaths you've taken to get to this moment. Then breathe one more. Strength is finding that next breath."
"Failure isn't the end, it's the beginning. Every failure brings a new opportunity to succeed."
"Every journey starts by taking the first step forward."
"If your brain is telling you to give up, just breathe. With one breath comes the next. Use that to get you to tomorrow."
\---
and my own personal one:
"As long as your heart is beating - it's never over."
| 21 |
Both Anhedonia and Anxiety treatments?
|
Hello, I have been struggling with anxiety, OCD, dpdr, and depression with Anhedonia off and on for years now. Everything that treats anxiety makes me Anhedonic and anything that makes me less Anhedonic makes me anxious. Im on edge constantly and I can't relax and take joy in anything my emotions are numb for the most part except irritation and the anger building within me everyday
I've been on bupropion 300mg for a year which helped a lot with anhedonia, depression and motivation but, it has made my ocd and anxiety worse.
So, a few month ago I added lexapro 5mg which only really made me numb and blunted did'nt even really help my anxiety just stuffed it in a bag pretty much. I was only on it for about two months on the lowest dose and I'm stilling feeling the numbness. It has improved a little bit since then but, it usually comes back. It also caused some sexual side effects but those are not my my main concern.
I have not idea what to do, I've tried everything now from countless supplements, to cold showers, I go to the gym regularly, I have tried diets and probiotics the list goes on and on. My psych wants to put me on an SNRI but, everything I've heard about them just says it makes anhedonia worse just like the ssris did. I have no idea what to do any more I'm at a loss. I guess mine I'm lucky compared others because, mine waxes and wanes instead of being a constant but, it never really goes away fully.
What should I even do at this point give SNRIs a shot or try something else? I don't know how much more of this shit I can take.
| 3 |
what is this called
|
sometimes i’ll get these thoughts and feelings in my head that everything i do is like embarrassing and like i need to stop and people like dislike me. it’s kinda like a weird paranoid obsessive neuroticism that comes over me. it’s like straight up just crazy negativity. does anyone else experience this?
| 3 |
Medication mood swings
|
Been on Viibryd for about 2 months and I’ve been having so many mood swings it’s sort of overwhelming. I’ll get INTENSELY sad or intensely sad + extremely restless / feeling “desperate”/ panicked or randomly calm, not worrying about what I was previously freaking out about or randomly motivated to fix my life or VERY irritable, not wanting people to be near me / not wanting to talk to anyone. I’ll be deep in one of these states, it’s not like a *little* sad or a *little* restless, it feels like I’ll be in a particular mood forever until it ends, despite me cycling through them daily.
I am cycling through all of these throughout the day, no particular order that I’ve noticed. I honestly feel like it’s gotten worse in the last few weeks. During the sad or restless phases my thoughts can get pretty dark
Anyone else having this? I am having some positives from the med so it’s not all bad and I don’t want to get off but this is a shitty side effect because once one of the mood swings ends I’m in disbelief at how I was feeling before and sometimes feel guilty depending on how I acted during it.
| 1 |
Something that helps with low energy/depression and goes well with Venlafaxine?
|
Hello everyone,
I've been taking Venlafaxine (brand name Effexor) for around 3 years now, on 150mg dose right now, for my anxiety. Lately, I've been working from home and it started to take a toll on me.
After I finish work, I have no energy to do anything else. House chores seem like a constant struggle, having a hard time doing anything at all.
I want to ask my psychiatrist, who I'm seeing at the end of next month, to give me something for low energy/depression but I'm a bit afraid on how it will interact with Venlafaxine. Any one who combines venlafaxine with other medication here?
| 6 |
Those of you who’ve tried Amitriptyline - does the tiredness wear off?
|
Since my dosage has gone from 25 mg to 75 mg I find myself extremely tired and lethargic, anyone tried this? And if so, did it wear off after some time?
| 3 |
Currently taking 40 mg paxil ,mirtazapine 30 mg ,amisulpride 100 mg and 300 mg bubropion ( wellbutrin)
|
I tried every medicine but still it dint help .I tried adding stimulant modafinil worked for me but it gave me high anxiety so I stopped .plz help me now what else should I try .I am hopeless
| 1 |
Amisulpride + stimulants any good?
|
Does amisulpride synergies well with stimulants like adderall or ritalin? Or any other stimulant like caffeine nicotine tyrosine yohimbine etc
Heard good things about selegiline synergising with stimulants thus making it possible to lower the stimulant dosage.
If only I could persuade my psychiatric nurse to let me combine multiple synergistic meds instead of using higher doses of 1 certain medication… :{
| 2 |
Does 50mg amisulpride aggravate anxiety?
|
Asked my psychiatrist for amisulpride because it was the least awful option of all the antipsychotics she could readily serve me.
After trying abilify and risperdal I was honestly a bit disgusted by antipsychotics in general.
Abilify gave me akathisia and insomnia while risperdal gave me inspiring anesthesia of the 6 kingdoms hell.
Recommended her to try vraylar or rexulti but she wouldn’t have any since she had never heard of any medications outside of the most basic old medication selection for autism.
She told me that I shouldn’t research and overthink too much about medications.
I was confused and frustrated. It’s apparently considering taboo to ask doctors for specific compounds. I’m still learning to softly persuade doctors to get a more favorable prescription. It feels like I’m a drugseeker junkie, ironic since I didn’t ask for any addictive recreational pharmaceuticals.
She gave me the choice between olanzepine or haldol, “Then we have tried all the mainstream options proven to work for autistic irritability” she said. Olanzepine!!! That stuff is straight up zombie fuel. I figured that she is just cycling through all the older antipsychotics.
So I asked for amisulpride knowing very well it wouldn’t be the best for treating irritability. At least I will get some more dopamine… got the lowest dose and took some today.
TL;DR:
I feel more focused yet more anxious and jittery.
But not the feel good energy perse.
Maybe it’s also because I just quit Risperdone and pregabalin, but I tapered pregabalin very slowly from 450mg to 75mg in 5 weeks and wasn’t on it much more than 2 months. Risperdone for only 7 days.
So is amisulpride good or bad for anxiety and autistic irritability? Or neutral?
[View Poll](https://www.reddit.com/poll/12lqemz)
| 1 |
Emsam experiences?
|
Hey everyone I’ve been on 6mg Emsam (transdermal selegiline) for almost 2 weeks, I know its not alot of time but I wanted to hear others experience of how long it takes to feel an affect. So far I haven’t experienced any changes, and no side effects. I’m seeing my psych week so I think we will probably go up to 9mg.
My most serious symptoms are severe execute function and anhedonia. I suspect it is a dopamine issue; SSRI/SNRIs have made me feel very emotionless and aggravated these depressive symptoms. Also tried Wellbutrin which unfortunately didn’t work for me.
I’m hoping that Emsam favoring MAOI-B will help increase my dopamine baseline and help with my symptoms. I know that Emsam becomes less selective at higher doses which I may have to go up to, so I was wondering if anyone has experienced any differences in effects between the doses as well (6mg, 9mg, 12mg).
I am planning on trying Parnate next if Emsam doesn’t work out and trying to stick to lower more dopaminergic doses.
Any advice/insight is appreciated.
| 3 |
Seeking advice on requesting a specific medication from your doctor
|
Apologies if this isn't the appropriate sub for my question. I'm suffering from pretty severe anhedonia and hypersomnia, and haven't had much success with SSRIs. I feel like bupropion might be a good option for me but I've always been too nervous to ask a gp for the specific medication I want to try because obviously they're more knowledgeable than me. I also don't have a doctor that I see regularly as they tend not to stick around for long in my rural area. Has anyone had a negative experience asking for a prescription for a specific medication? Would I be better off seeing a psychiatrist?
| 6 |
People who gave up on Trintellix.... What worked instead?
|
I'm on the usual whirlwind tour of trying out different medications that sort of work (some mixture of depression, anxiety, ADHD).
ADHD meds (alone) - focus but depression
Lexapro - no anxiety or depression but sexual dysfunction
Wellbutrin - horrible anxiety
Strattera - focus but high blood pressure
Trintellix - seems great for depression but not so helpful for anxiety (I'm at 20mg, the max dose)
I'm conflicted as to whether I should ask about adding buspirone or just move onto another med.
For those who had a similar Trintellix experience... What did you take next?
| 6 |
As much as I hate to say it - long term use of Alprazolam at 2mg per day is an essential part of my treatment
|
99% of the time, I'd say Benzodiazepines are a "HELL-NO" for any use longer than 2 weeks max. A lot of the time, people have to keep upping the doses to feel a benefit, and the withdrawals are arguably the most painful of any drug in existence (greater even than opioids) - not only because of the intensity of the pain (which can even cause death), but because of how unbelievably long they can last. We're talking weeks, even months, of endless pain - both mentally and physically.
And Alprazolam (Xanax) is the most notorious of all, because it is the fastest of all the drugs to leave the body. Not only that, but as I learned through other folks in the medical field, Alprazolam is the benzo that alleviates anxiety symptoms the most and has the least effects on peripheral stuff like muscle relaxation and convulsions - so even substituting it with alternatives like Diazepam and Clonazepam, whilst certainly helpful, still won't quite reach the same level of efficacy.
Here's a simplified version of the chart for those curious:
[Reddit - Dive into anything](https://www.reddit.com/r/HowDrugsWork/comments/ejqlmo/benzodiazepines_a_highly_intriguing_chart/)
I have to say though, after a good 4 years of long periods on it, and long periods of successfully tapering off of it, I must put my hands up and begrudgingly admit I simply need it as part of my regime, whether I like it or not.
DISCLAIMER: DO NOT TAKE ANYTHING I SAY AS GOSPEL, NOR ASSUME THAT ANY OF THIS WILL APPLY TO YOU. I STATE AGAIN, BENZODIAZEPINES ARE ONE OF THE MOST, IF NOT THE MOST, DANGEROUS DRUGS IN EXISTENCE TO BECOME INVOLVED WITH.
Even when I've (somehow) managed to gradually taper off it and go weeks without it without the devastating withdrawals, I find that my mind still cannot function as optimally without it. Longest I've ever taken it regularly was 2 years straight - in that 2 years I never ever was inclined to increase the dose. The efficacy remained about 95% the same throughout. The major downside is that I have to ensure, come hell or high water, that I never ever EVER run short-supplied, or it's like opening the door to the worst tortures of hell. I'm really not kidding. I can confidently say without the medication for me personally, I'd probably be dead by now.
And from what I've read in scientific literature, there are a select few patients who have had inadequate response to practically any other treatment in existence; they were only able to pull it together once some kind of GABA - agonist was included as part of their treatment.
To reiterate, I AM NOT ADVOCATING USE OF BENZODIAZEPINES, AND CERTAINLY NOT TO PEOPLE IN GENERAL. I'm merely stating that if there are others like me out there who (I'm sure the minority of people) uniquely have a beneficial response to long-term benzodiazepine use: don't feel ashamed about it. Just make damned sure (like literally the top priority for the rest of your life) to never, ever become short-supplied of this medication, because if you ever do: Welcome To Hell.
| 15 |
After being stable for a year, everything is falling apart again
|
for some background, I was doing really well with my medications (diagnosed with TRD and GAD) over the last year up until about 3 months ago. Since those 3 months, I don’t care about anything anymore. I don’t give a damn if I stay in bed all day. I just don’t care about anything at all. And it add to it, I’m constantly paranoid and anxious and not really sleeping too great. All symptoms that were controlled up until these past 3 months. And it’s only getting worse. Nothing changed (no diet changes, no significant stress, no trauma) and dosage changes of my current medications isn’t helping my symptoms. I’m just so clueless on what to do. I’ve tried 25 meds over the past 5 years and I was so happy that I finally found one to work. But now I’m back to nothing working.
| 3 |
Should I stop taking Zoloft?
|
I started on 50mg of Zoloft almost 2 weeks ago now. I've read a lot of different things saying that the first couple weeks usually have the most side effects, and that seems to be the case with me as well. For the first week my anxiety was through the roof, however now I don't feel as physically anxious but I feel 10x more depressed. I have no motivation to do anything what so ever and the thought of going into work is awful. I feel like I'm forcing myself to live through the day even more so than before I started the medication.
I am wondering if anyone here has had similar experiences, and if it gets better once the medication starts to fully work. Should I call my doctor now or just keep taking it until my follow up appointment 4 weeks from now to see if it gets any better?
| 3 |
a week into wellbutrin and I feel more depressed and insulated
|
so until 1 week ago I was taking 125 mg lustral (is it the same as zoflt?) + zollinda (abilify) 3 ml
things didn't improve for about two months so I went to a different therapist and he added wellbutrin xl 150 mg and upped lustral from 125 to 150 for the first week then 200 for the rest of the month (abilify stayed the same since I tried upping it with my previous doctor but it caused me sever pain so I had to lower it to a manageable dose, I still feel slight pain still though)
at first (with wellbutrin) 2 days I felt more anxious and I had more anxiety than usual but it wasn't unmanageable then from the 3rd day until today I feel about the same as before I started wellbutrin but I feel more insulated and an empty sensation inside
I had bad depression for over 10 years and in the last five I started to have anxiety as well with rare but intense panic attacks
I thought wellbutrin suppose to do the opposite? is it too early to tell? I am scared it won't work just like the other drugs I tried in the past. I don't think we have wellbutrin sr in my country only the xl, is there a big difference between the two? I was optimistic it well help with emptiness, fatigue and productivity since it seems to be working for a lot of people hear
I need some advice, I feel so lost
| 1 |
Does high dose methlfolate (Deplin) work for depression by depleting riboflavin and inhibiting MAO?
|
I've often wondered if the mechanism in which large doses of methylfolate (15mg) works is by depleting the person of B2 and acting as an MAOi. Anyone know if this is a mechanism?
| 2 |
Which AD for obessive thoughts and regret?
|
Does anyone have a recommendation on which AD can help with regrets? It's been 5 weeks now since an event put me into depression, as I can't stop thinking 24/7 of something I should have done. I can't stop obsessively thinking about the wrong decision and what could be now.
I can't sleep at nights, waking up every hour, can't focus at work, I don't do any activity that I used to do before, there's no time or place during the day where I find relieve. I thought time would heal it and I would forget, but it's getting worse.
I have an appointment next week with a psiquiatrist but I'd like to go with some suggestions.
| 5 |
Therapist suggested I go on SSRIs for a bit. I’m not sure how I feel about it.
| null | 1 |
Mitochondria dysfunction and bipolar disorder: From pathology to therapy
| null | 11 |
Anhedonia therapy
|
This is a win with anhedonia. I persisted and finished it. Making gifts helps because you can imagine another's happiness even when you can't feel it yourself
| 32 |
Long-time Poster. I am currently in remission. Here’s what worked for me.
|
Hey guys! So I am very happy to report that I seem to be in remission. My overal outlook and energy have been much better the past 3 weeks, and I’m starting to feel confident that I am going to remain stable.
Obviously what I did may not work for you. I just wanted to share because it did take time and a lot of experimenting.
I am ADHD - Primarily Inattentive type. I was diagnosed when I was eight years old along with a learning disability called “dysgraphia.” Basically when it came time to learn how to write in cursive, I was unable and even my printing was borderline unreadable.
I always felt that ADHD fueled my depression. Not the other way around. But for the most part, I was treated for depression over and over again before even exploring stimulants or ADHD treatments.
Anyway, most recently it was more of the same:
Prozac 60mg
Wellbutrin XL 300mg
Trazodone 100mg
I finally had enough. Same old. Huge weight gain, no sex drive, total apathy, etc.
Let me also include that I am a chronic pain patient. I developed a dependence on Kratom and that really harmed my mental health over time.
I was finally ready to try an MAOI and not going to wait to be prescribed. I decided to try Selegilline.
I made some serious mistakes with some of my addictive tendencies and tried mixing it with PEA. I made myself extremely sick and felt like an idiot.
But I have found a perfect dose and regimen that works. Here’s what worked for my particular case: MDD, ADHD, Severe Chronic Pain
**The Regimen that Finally Worked**
Wellbutrin XL 300mg
Deprenyl 2.5mg (sublingual)
Lyrica 300mg
Suboxone 4mg
I just feel “well.” I’m not over the top stimulated or bouncing off the walls.
Deprenyl at this dose has been very subtle. Wellbutrin is one of best and safest antidepressants to pair with it. Lyrica makes a HUGE difference to my depression and enhances my sleep quality drastically. I know some will roll their eyes at Suboxone, but it keeps me away from Kratom which destroyed my mental health, and it works well for my chronic pain. I have to admit it’s good for depression in it’s own right. Finally…getting OFF the SSRIS and SNRIs is the final key to my success. I’ve been on one or the other for 6 straight years: Effexor mainly, but Celexa, Prozac, Cymbalta, and Viibryd as well.
My stack is well suited for those of you who struggle with depression but also have ADHD and have developed substance abuse issues trying to compensate for a lack of dopamine. I never thought I could get better. Please don’t give up. Keep experimenting.
| 14 |
PSSD ruining my life. Can someone here give me hope? I’ve had it for over 3 years
|
PSSD has given me no libido, numb emotions and numb & pleasureless orgasms. Totally life ruining beyond belief. This is from taking an SSRI antidepressant for only 25 days back in 2019. Anyone give me hope please? I can’t go on much longer
| 3 |
how many with pssd/drug induced anhedonia have successfully treated your mental issues with a psych med?
|
anybody with some fucked up cognitive, emotional , obsessive, anhedonic and pssd issues actually managed to improve significantly from psych meds? please tell me your story
| 6 |
What are your thoughts on this DW Documentary on Depression Medication?
| null | 3 |
Life changing
|
Life changing( please need advice)
Most of us go through a lot in life . I never had anxiety but had to deal with many issues in life . Unfortunately I had accident and I was not able to be BUSY like before.
So for almost one year I was at home . During that year I had issue with insomnia and the doctor put me into SSRI.
Now , I am thinking how much being busy could help us to deal with anxiety and depression. I never had anxiety or depression but after losing my job and being at home I started to have mental issues.
| 1 |
Paroxetine and propranolol
|
Hi all
I am taking 20mg paroxetine for anxiety and panic attacks with mixed results. My doc proposed adding propranolol when needed and I feel like it may be really good idea as my anxiety manifests mostly by physical symptoms.
However my psych doesnt know/give a shit about interactions and me, health anxiety sufferer, cares about it too much.
I am worried about enzymatic interaction between paroxetine and propranolol, cause both of them are metabolized with participation of CYP2D6 enzyme. Paroxetine is one of the strongest inhibitors of thus enzyme with ki about 50nm so I guess propranolol levels in blood will increase over time.
I couldnt find any study with this particupat combination, but I've got one metaanalysis that investigates interaction between paroxetine and metoprolol, betablocker with similar metabolism. Reviewed studys found 3-4 fould increase of metoprolol plasma levels and some incidents with Atrioventricular Heart Block, which worries me the most.
https://pubmed.ncbi.nlm.nih.gov/30248178/
What do you think about this combo? Have you ever tried it? Will I die?
| 2 |
Doc brings up ECT as treatment; I’m scared, and don’t want to do it
|
So I am a 58 year old post menopausal female. I’ve suffered from anxiety and depression since I was a teenager. Diagnosed with fibromyalgia in my early 30s. I was on Cymbalta for 13 years until I hit post menopause when it quit. It caused severe, suicidal ideation. I didn’t know what it was; I’ve never had it before. I saw a provider (not a psych; a physician assistant) who tried Rexulti, Abilify, Trentellix (not very long), Pristiq (not long at all) and then back to Cymbalta with Lamictal. I was also seeing a counselor at the same practice. Everything has been discontinued except the Cymbalta.
I have left the first practice. The counselor wasn’t very good and I don’t believe the PA was really able to handle my condition.
I have since started seeing a new psych and therapist. I like them both so far.
I discussed possible ADHD with them both. Therapist thinks I suffer from it. We’re going to talk about it more. She wanted me to talk to my psych about medicine for it since I was still depressed on Cymbalta. my psych said she would not do anything about it until I was actually tested for it. She told me there was a four hour test involved .
Psych told me she wanted me to try Vraylar and if that doesn’t work I’m running out of options. One of the problems is I am very sensitive to medications. She brought up ECT. This is my second appointment with her; she talked about ECT at my first appointment as well.
I am super reluctant to get ECT done. I don’t wanna lose my memories or anything else that it may do to me.
I asked her if we could try Wellbutrin for now with Cymbalta. I’m at 120 mg with Cymbalta. We’re trying Wellbutrin first and I guess if that doesn’t work Vraylar.
Also, I can’t take hormone therapy because of my breast cancer risk. I tried ketamine infusions, which were done once a month for pain. I saw no difference in my depression.
Anyone been in this position? The thought of ECT really scares me. I thought if anything we could see if my insurance covers TMS. I am really scared!!
| 12 |
Akineton(biperiden) plus ssri
|
Anyone try it for depression. I have low dopamine only ssri I can use But I have akathisia and low dopamine effects i think It call EPS. Anyone can help?
| 1 |
Does anyone take Vyvanse primarily for treatment resistant MDD?
|
To the degree that I have ADD, I'm convinced it's a byproduct of the depression. Historically, until the shortage, the only med that worked was methylphenidate er, 20mg, 3X daily. Since it's impossible to get a script filled, I'm taking 50mg of Vyvanse. For me, it works well... but only for 6-7 hours, and then I become a vegetable.
Does anyone have a similar problem or solution?
(n.b., none of the 20+ anti depressants or anti psychotics have done sqat... that's how I landed on methylphenidate.)
| 5 |
Valproate/Lamotrigine + Sertraline combination - looking for experiences
|
After further conversations with my docs, I got prescribed a new schema to follow. It's thought to be a resistant case and one of the doctors suspects I might have something along the lines of affective disorder.
I am currently taking Bupropion 150 mg and Gabapentin/Phenibut (due to a new spike in anxiety). The new schema would include Bupropion + Lamotrigine or Valproate + Sertraline + Gabapentin (for sleep, since my doctor thinks I can't go without it after a month of taking it, although I believe it can be cut out completely). Valproate was looked into as a quicker option, since it's easier to get to a higher dose and also it's easier to find the right dose, according to my doctor. I am quite worried about the hormone changes and liver toxicity, though, so Lamotrigine is more likely to be tried out first.
So, I wanted to hear people's experiences **with the combination** (either with or without Bupropion) or with **mono-therapy** for anxiety-depressive states.
| 1 |
Best med or combo to help anxiety/insomnia?
|
Hi all,
Currently I’m on wellbutrin xl for 5 months and doxepin 10mg for 4 months for sleep. The wellbutrin isn’t working nearly as much as I want and could be the cause of severe acne. My doctor wants me to wean off the wellbutrin and get on Zoloft but I’m so scared it’s going to mess with my insomnia and just in general as I don’t tolerate adjusting to meds well.
I am putting my two weeks notice in this Friday so was almost hopeful to just stay on the wellbutrin to see if maybe it’s the extreme stress from work doing it….I just really don’t want to go through any adjustment phase again lol
Has anyone else found better success in either for anxiety/insomnia??? Any advice would be greatly appreciated!
| 3 |
Dopamine increasing meds
|
Hi all,
What meds do increase dopamine at least at a low level like bupropion as it helped me on the past.
Regards
| 16 |
Dopamine blood level abnormal
|
Hi everyone. I know there’s no accurate way to test for neurotransmitters but during my last doctors visit my doctor tested me for both dopamine and serotonin via blood test
I often have fatigue and feeling unmotivated. I don’t feel “sad/depressed” just always tired and never want to do anything. This is even after getting my thyroid in a good state with looking at many other things such as iron levels b vitamins and anything you can think of…
My serotonin came back fine but my dopamine shows below normal. Like I said I understand you can’t go by it 100% but I had suspicion of a dopamine deficiency. Whenever I looked up what the symptoms are I could relate to all of them. I also recently got prescribed armodafinil which I take from time to time. Not only does it make me feel more awake but it makes me feel just happier in general. Not like a high/mania feeling but just normal. From what I know armodafinil is a weak dopamine uptake inhibitor so that would make sense.
I’m asking on here because my doctor is away and I can’t see him until next week. What do you think about this? What do you think treatment would be if you were to hold weight in this test?
Thank you.
| 2 |
Fluoxetine with Venlafaxine combination effect on cognition
| null | 4 |
Paroxetine For CPTSD and Social Anxiety?
|
Hi there,
Complex-PTSD and Social Anxiety are slowly killing me despite countless medication (SSRI, MAO-I, Benzos, and the list goes on), various psychotherapies, meditation, lifestyle interventions.
I am thinking about trying Paroxetine. I have a huge startle response, hypervigilance, Dissociation, Freeze response and avoidance behavior, avoiding eye contact, stuttering, going blank in social situations.
Does anyone have experience with this medication for CPTSD and social anxiety?
| 2 |
KSM 66 aswhagandha emotional blunting anhedonia and anorgasmia after just one Dose
|
so i took 4 days ago KSM 66 300 mg 5% withanolides for the first time and one hour noticed strange feeling that reminded of one time wish i took an SSRI and quickly ditched (took it only once) years ago but with the SSRI the next day got back to normal but now with ashwagandha which i took only 2 times and 48h passed and still feeling anhedonic and very limitiang i can notice my emotions but they so weak and shallow can't even cry but feel hopeless.. if more people take time and post about their experiences i would really appreciate it especially about KSM 66
btw i dont take anything beside ashwa (and i quit it forever)
| 6 |
What to add to vortioxetine? Mirtazapine or bupropion?
|
I am currently on 5 mg vortioxetine and 15 mg mirtazapine..mirtazapine works well with anxiety but hunger and next day drowsiness are a cons.
I was on the past on bupropion and it helped with energy and motivation but not as well with anxiety.
Not sure what combo would help more with anhedonia and anxiety.
Thanks
| 2 |
I miss Wellbutrin so much. Anything similar?
|
I had a seizure on Wellbutrin just over 6 months into taking it a few years ago. Because of that, I had to stop taking it. I know it’s weird to say about a medication, but I miss it so bad. I was always so motivated, energetic, and genuinely felt happy most of the time.
I have photo memories of me cooking so much good food in that time and baking Christmas desserts for like a week straight. Since then, I’ve never really cooked much because I just don’t ever feel motivated or good in general.
I was still in school at the time and applied to all sorts of jobs and internships. I got the job I have now during that time. Before my virtual interview, I went on a run and then had a better interview than I’ve ever had in the past. That’s fucking crazy to me! I’m not particularly happy with my job now, but seeking anything new seems like a mountain of a task.
I’m not saying I don’t have good periods anymore, but it was just such a general constant feeling when I was on Wellbutrin. I feel like shit as I’m typing this and I’m tired of feeling this way.
I’m currently on Lamotrigine and a small dose of Adderall but I just don’t ever feel quite right. I’m seeing my psychiatrist next week and might bring all of this up. Does anybody have experiences with alternatives? I tried Prozac in the past but absolutely hated it because it made me so emotionless and numb. It just made it worse.
| 8 |
Starting Lamotrigine
|
I have a few questions. I started Lamotrigine 25mg 3 days ago and haven’t really felt the best on it. I contacted the psychiatrist and they suggested taking it every other day.
1. While getting on this, did anyone else start out taking it every other day for 2 weeks getting used to it?
2. I know it’s a mood stabilizer but can this make you feel worse before you get better? Thank you in advance.
| 9 |
how do you manage mood fluctuations? how do you manage low moods and energy levels?
|
For the past one year I have been working on my mental health. Taking therapy sessions, putting efforts in being aware of my thoughts, changing thought patterns, eating properly and things have gotten relatively better for me.
I'm no longer at the stage where anything and everything made me miserable.
However, I do experience fluctuations in my mood. My therapist had warned me about this.
Most days, I'm okay and things are manageable to an extent.
Some days randomly, without any triggering thoughts, I start feeling low and unmotivated and drained.
The next day, the smallest of things get me angry or annoyed. And I'm just crying and getting frustrated, feeling absolutely drained and distracted.
I understand that such fluctuations will happen.
But how do you navigate around this? How do you manage such days?
Please let me know if you have any kind of advice for managing low moods.
| 19 |
Is it normal to have “breakthrough” suicidality on a full dose of lexapro?
|
Hey all! I have been on 10mg lexapro for a few months and day to day am feeling good and very happy. However one or two days a week I have days like I used to-intense suicidality, crying all day. I don’t know if the answer is to keep increasing the dose of lexapro bc on an average day this dose is perfect.
Has anyone experienced random intense suicidality?
| 6 |
Losing interest in all things
|
I've completely lost interest for almost all things, and it's been this bad for more than a year now. E.g I won't draw, play instruments, go hiking, bake, play videogames or even watch a whole movie (that I've looked forward to watching). Those are activities I used to do and found meaningful. I recently quit Trintellix because I wasn't feeling an effect from it (might've given me a bit of energy the first few months though - started Dec 2021) and the side effect was nauseua which I wanted to be rid off. But I also feared it might've caused this disinterest. Now after two months off I don't feel any difference in my mood, I just might be more emotional than before.
I'm mildly depressed and highly anxious all of the time, I can only experience fragments of happiness. Every once in a while I force myself to do something to maybe feel good, and hopefully lift me up out of this slump, like going to a concert or buying myself flowers. But there's no change. Now I'm wondering what's gone wrong, if anyone out here has felt the same way but turned it around, and if Prozac has helped (because it's what my doctor suggested me to start taking instead of Trintellix)?
Maybe worth a mention is that I have OCPD, and almost all things I've lost interest in is basically some form of performance, which I struggle handling. "Watching a movie" isn't an achievement from me though so... Almost all things.
| 4 |
Receptor question
|
Why is it not possible to find out exactly which receptors are dysregulated with each mental patient so that a more targeted treatment can be initiated? I mean it is known how each medication is affecting each receptor and also what each receptor does (how did they find this out btw?). Surely it would be possible to use something like fMRI to work out which receptors are not working properly (or working too much?).
| 2 |
Does adding stimulant works for treatment resistant depression ??
| null | 15 |
Winter is extremely harsh on me mentally. Without getting into too much detail, it almost pushes me over the edge. Should I move to another state for my mental health, leaving my family behind?
|
For reference, my culture is quite family oriented. Leaving my mom and little brother behind would be tough for both parties. However, I'm not sure I can endure another winter in my state. It's a very big decision to make. I only have my mom and my little brother in America, so leaving them is leaving my only family. Please help me rationalize this decision
| 8 |
I need help(chronic atypical depression) any experience with vortioxetine (brintellix-trintellix)
|
Here i'm.again
Atypical depression definitition is this
Hypersomnia
Hyperphagia
Mood lifts with good events
Leaden paralys( heavy legs and arms)
And rejection hypersensivity
I have tried allá ssri , snri ,anyone have tryed vortioxetine.with success for atypical depression???
| 1 |
What works for treatment resistant depression ???
| null | 3 |
0.5mg or even 0.25mg makes me feel really tired
|
Switched from pregabalin to risperidone because pregabalin because of tolerance issues with pregabalin. Was very hesitant since I read all the bad stories about it, but wanted to give it a try after my therapist said online forums like reddit probably have a selection bias. Started on 0.5mg risperidone 4 days ago and boy were my suspicions correct! Yes it calms me down and makes me sleep very well. But it also makes me dizzy, lazy, weak and foggy.
Tried 0.25mg last night and still was tired the whole day. After some neurotic google searches for pubmed studies and reddit posts about risperidone I found out has a lot more affinity to the 5HT2A receptors then the dopamine D2 receptors. It also has considerate affinity to the Alpha 1A&2A receptors and histamine 1 receptors, which would explain the fogginess(brainfog) and dizziness from lower bloodpressure.
But at 0.25mg risperidone should probably mostly affect the 5HT2A receptor the most doesn't it? Does this also cause fatigue by any chance?
These are the major Ki values of Risperidone:
5HT2A: 0.2; Dopamine D2: 3.2; Alpha 1A: 5; Alpha 2A: 16; H1:20;
Did anyone who has tried this med in similar doses also experience something similar? I think I just hate antipsychotics, think they're probably only good for schizophrenics or during benzo withdrawals or something.
| 1 |
More Supplements ? help please !
|
Hi all, I suffer from depression and social anxiety.
After trying some anti depressants (effexor, zoloft and Trintellix) I found that they help me a lot, but the side effects are not very nice and the potential for long term issues with sexual health etc. is something that came to my mind after tapering effexor and zoloft too fast (that is not a nice experience).
I have been doing therapy (psychoanalysis, CBT, bodywork etc.). - nothing ever helped as much as effexor did. I recently tried a lot of different supplements such as minerals, vitamins, NAC, st. john's wort, GABA, 5HTP, L-theanine, SAM-e, Tongkat ali, lithium orotate, some different racetams and more that I dont remember right now.
Did anyone try L-Tryptophan, DLPA and L-tyrosine ? can you recommend it ?
Also, anyone who tried TMS (transcranial magnetic stimulation) ?
Thank you all
| 4 |
How do you deal when your family & friends are tired of hearing about your depression?
|
How do you deal when your family & friends are tired of hearing about your depression?
I mean from their perspective I get it, im sure it’s very draining to hear someone talk about being sad all the time, etc. but obviously it makes it harder for the person with depression to feel like they can’t really talk to anyone about it.
And my best friend set all these boundaries with what I can text her and what I can’t text her because it’s Too stressful for her. And again I get it depression can make you selfish for sure because it is so all consuming but right now I just feel like I’m really struggling and I feel very lonely and like there’s no one I can talk to about it.
| 23 |
Can Smoking( Tobacco) affect antidepressant work? I smoke 10/20 a day
|
Im using Paxil 20mg. If anybody know pls answer.
| 3 |
would adding wellbutrin help?
|
so i’m currently on 900mg of lithium and 400mg shot of abilify. ive been doing some research and i’m curious about wellbutrin. would it help with the depression (low dopamine) caused by the abilify? Ive been struggling with anhedonia and not enjoying things like music. i’m seeing my doctor next wednesday.
| 1 |
I have tried benzos with no relief. Has buspar worked for anyone for which Benzos have not worked for them?
| null | 8 |
People who tried different SSRI and had night sweats - did switching to a different SSRI help with it?
|
Basically, I had a conversation with a doc I visited before. I have told her my medical history + issues with night sweats both on paroxetine and escitalopram, but she still wants to try sertraline in a combination with a different med for me. I am quite wary of potential (same) side effects and my sleep getting worse, but she is claiming it's milder than the other two.
**Did anyone have experience with night sweating with one SSRI, yet didn't have it with a different one?**
| 3 |
Regimen Advice For Bipolar
|
My doctor advice Effexor 150mg, Wellbutrin 150mg, Divalproex Sodium 500mg and Risperidone 2mg for my bipolar disorder, aggression and treatment resistant depression. I'm afraid to start. Shall I give these medicine a try? Advice please
| 3 |
Anti-psychotic helped my anxiety?
|
Idk if this is normal but my psychiatrist added zyprexa (Olanzapine) and its strangely taken most of my anxiety away. My anxiety is pretty resistant to most medications but adding 2.5 mg of Olanzaopine to the 70 mg of effexor and 40 mg of atomoxetine seems to be like the perfect regimen but I dont really get how zyprexa, an anti-psychotic would help but it just mellows my brain out and I dont fixate on things and rarely have intrusive thoughts does anyone else have any experiences with anti-psychotics for anxiety?
| 12 |
Clomipramine 6.25-12.5 mg shouldnt decrese dopamine?
|
Hi guys I Just get Anafranil. Started at 6.25 last night. I have low dopamine and serotonin. 3 times hospitalized. Nms syndrome after Sulpiryde and all neurolepic pills which before never happened. And akathisia after trintelix and low dopamine symptoms (all gone after 2 weeks) curtently i shitty condition 2 mg of Lorazpeam. I was only on 0.5 mg But thanks to. One dr i stopped and started again and now i have to take 2 mg. So sad. I see now why. I have sfpn long story overdose b6 ruin my life my brain and nervous system. Depression which I never had before.
| 1 |
How important is consistent medication times? (mirtapazine)
|
I struggle with taking my medication (15mg mirtapazine) at the same time every day. I'm trying my best, but the closest I tend to get to consistent is a 4-8 hour window in the general area of "before bed". All the information I've been given emphasises taking it at the same time each day- I genuinely don't know if I can actually do that. WIll it be rendered inneffective by the inconsistant timing?
| 3 |
The song "Hotel California" has a whole new relevance since being dependent on medication indefinitely.
|
Every once in a while there comes a time where I may feel like attempting to cease the meds I'm on, just to get rid of all the inconvenient side effects.
But sooner or later, whether I like it or not... boom, all those horrible symptoms come back again. Then I have to almost immediately rush back to the meds again, like a villager rushing for shelter during a huge storm.
As Irritating as the side effects can be, I think life without meds can be far worse. I can't help but think back to the song by the Eagles "Hotel California", particularly the final verse: "You can checkout any time you like, but you can never leave."
| 21 |
Does adding wellbutrin works well for treatment resistant depression??
| null | 7 |
Pristiq and Wellburtin, why am i feeling like this
|
Does any have any experience in this ?for about a month now. I take both once i wake up.
So far, it has been good, the past couple of weeks i have been am in a great mood.
In the initial weeks, it was not good, i was extremely depressed, but i understand that is a known side effect.
I have been laughing alot, for every simple thing, which is fine.
But i am extremely restless from the time i take the meds till about 5hrs later, the restless will be gone for an hour and then it wil come back again for the rest of the day.
I am so restless that i can do anything besides lying down on my bed. And i have been sighing constantly like non stop.
So at night i need to have a couple of beers to calm down, even with the beers, i cant sleep. I am wide awake, so i take zopiclone.
​
My doc has given me Xanax XR 1 mg as well, which doesnt work at all.
​
Apart from this, the good mood i am feeling, seems rather strange, i am not sure if it is because of the meds, or it is because i have not been in a good mood for many many year, that i so used to it that when i feel good, my brain panics...
​
​
Does any have any experince in this ?
| 4 |
Plz mention all the list of medicine which worked for TRD???
| null | 2 |
It really sucks when you're in the grip of depression
|
Lately it's hit me harder than ever. Logically I can think of the reasons and potential solutions, but another part of my mind still can't seem to snap out of it.
I think Leonardo Da Vinci said it perfectly: no matter how we want it, "tears come from the heart, not from the brain."
| 31 |
Stress making me sleep all day: side effects or just a symptom?
|
I'm on my current prescription since last July. This combination is the only one that has been working so far. I'm getting much better, can function normally. External triggers sometimes can make me disturb but I can recoil from it pretty easily. Now two things I am noticing:
1. I don't panic under stress. If I have a deadline and have a mountain of work to be done, I can't feel the stress or anxiety, both physically and emotionally. I'm so used to panic in such moments, nowadays it makes me uneasy like I should have a certain anxiety to make me work.
2. If I am invested in something, or working with all my attention, after a certain point I just need sleep! If I am workings for 4 days in a week, fifth day I can't get out of the bed and will be sleeping the entire day. This has been a common occurrence and the frequency of such behaviour depends solely on the work I am invested on. For example last Saturday I slept whole day, then Tuesday and now today. During this time I don't even feel like hungry. If I wake up inbetween I may have something quick then I will sleep again. After sleeping the whole day the next day I feel normal. Not like I have slept for an insane amount.
I communicated this to my doctor and he asked whether I feel fresh after this period which I do. He said it's completely fine and just my brain needing more time to rest.
My present prescription:
1. Lithium salt,
2. mirtazapine,
3. Desvenlafaxine,
4. Escitalopram Oxalate,
5. Armodafinil.
(I have been put on multiple combinations of medication and this is the only combination that has shown any response. My doctor has agreed to decrease the doses and medication gradually after 4 months. I don't want to get criticism for my medication because in past it has given me panic attack, but want to no whether my oversleeping is just a normal brain function or side effects of my medication. I'm final year STEM PhD student with ADHD and OCPD along with MDD and GAD, if that helps.)
| 2 |
Seeking advice about Effexor
|
My psych doc recently prescribed me Effexor for depression and anxiety, as well as adhd. I am very hesitant to try it because I have heard it can have problematic side effects and is very hard to get off of. Im mainly worried about insomnia, feeling tired during the day and mental sluggishness.
For additional context, I take 36mg concerta as well.
I have tried zoloft, lexapro and prozac before with decent results but eventually I developed mental foggyness and persistant feeling of fatigue/tiredness, and then insomnia which made the previous symptoms.
I am also wary of it helping with adhd and interacting with 36mg concerta I currently take.
TL;DR: my questions are?
How bad are the side effects?
Does it cause insonmia?
Does it cause daytime tiredness?
Does it help at all with ADHD and difficulty to concentrate?
| 6 |
Is 5 medications too many? Especially when you don’t feel any improvements?
|
I take 5 medications. I don’t feel any better. Is this overkill?
| 9 |
I have instant tolerance to anything good
|
I am a young male in early 20s with depression and ADHD. My situation:
- constant physical fatigue - the simplest actions like walking are given with great difficulty;
- constant mental fatigue, I have good mental abilities, but I think very slowly and get exhausted very quickly during the solution of any mental task;
- constant emotional fatigue - any even slightly significant event makes me feel emotionally exhausted;
- anhedonia and lack of motivation is the most important thing for me; listening to music, walking in nature, watching movies is almost not a pleasure; communication is absolutely not a pleasure, it is difficult for me to exchange even a couple of words with a person without subsequent feeling even more tired or irritation; the only thing that is strikingly always motivated is to find a solution to my problems, for example, writing this post;
- I sleep a lot, I always want to sleep, getting up early in the morning is almost impossible;
- very difficult to concentrate;
- a little depersonalization / derealization, I feel cut off from what used to be pleasureable, and many things are like not from 1st person view.
What bothers me the most is the lack of motivation. It doesn’t matter to me whether my mood is bad or good, but motivation is important to me, the main 'feature' of my depression is zero motivation. I have big goals in life, I am a capable person, but with the current level of motivation, it is difficult for me to brush my teeth, not to mention some leveled goals. So far I'm not even able to work.
It's weirdly funny that I usually feel motivated for just a couple of seconds. An idea, like 'go outside for a walk', comes to mind, I feel intense motivation and energy for for 2-3 seconds, and then I instantly lose this motivation.
Other non-mental illnesses that I have: food allergy, x5 elevated immunoglobulin E of normal. (I also used to have a lot of allergic skin reactions, but when I stopped avoiding these reactions, for example, I began to choose the first shampoo that came across, not hypoallergenic, and just allowed the skin to become inflamed, all skin allergies completely disappeared in a couple of years, although I am still sensitive.)
Mental illness other than depression and ADHD: not diagnosed, but meets criteria for narcissistic and antisocial personality disorder.
I gave general (and some specific) urine and blood tests, everything except immunoglobulin E and testosterone is normal. Testosterone is not below normal. It's higher. In general, physically I am a pleasant looking, well built young man.
My depression and functionality in general improves greatly always in these cases:
- with sleep deprivation;
- if I don't eat anything;
- if something extremely pissed me off, upset me, shocked me.
The latter is especially offensive - in fact, in order to start feeling good, I have to feel terribly shocked, get bad.
And the latter I want to describe this, even more offensive symptom: I very quickly develop tolerance for things that increase my mood and motivation. Instant tolerance. Like nothing can help me. For example, a month ago I accidentally discovered that 20-30 minutes of being under the bright sun gave me really good feelings, my depressive mood improved significantly for a couple of hours, I could concentrate better. I started sunbathing, on the 1st, 2nd and 3rd days it worked, on the 4th there was a 50% effect, on the 5th and any subsequent attempts, including after a couple of weeks, didn't produce any effects.
The next example of instant tolerance. My doctor prescribed venlafaxine for depression. The first week I felt a complete relief from depression, I began to improve my life. In the second week, the positive effects were completely gone and never returned for six months.
There is also a recent example. The day before yesterday, the doctor prescribed me Adderall, we started immediately with 30 mg IR. After the first dose, I felt a complete cure for depression and ADHD. The effect lasted 2 hours. The rest of the day I felt just anxious, such, you know, anxiety in the background. Yesterday the effect lasted 30 minutes. Today there was no effect at all, I didn’t even have hunger suppression today.
In general, with any medication I have noticed, I always need a dosage of 2-3 times more than the average person to get the same effect in strength and shortly after I don't get any of effects.
This symptom of instant tolerance is why I wrote this post. How can this be explained? After all, this with some probability means that no medicine will ever help me - because my body instantly develops tolerance to any good thing and treacherously returns me to depressive state of main.
Tl;dr I have many years of depression, the main problem of which is zero motivation; any medications and practices (antidepressants, Adderall, sunbathing, physical activity) work only for the first 2-3 days, after that I feel zero effect, always. What can help me then?
| 17 |
Sertraline and green tea/bananas/chocolate/avocado/etc. - will it actually cause a bad interaction?
|
Just got prescribed 50mg sertraline and read online that some foods I regularly eat are considered bad, and may cause a blood pressure spike or serotonin syndrome. What are your experiences? My doctor didn’t mention this.
Green tea, soy beans (veggie products), bananas, chocolate, avocado, coffee, are all foods I eat basically daily. Do I have to totally cut them out? Thanks
| 2 |
I was okay then i wasnt?
|
Hi!
I am on wellbutrin 150 mornings and topamax 50 + seroxat 40 + lexotan 1.5 at night
I used to take ritalin 10mg instead of wellbutrin until two days ago, and started topamax like 3? weeks ago. Since topamax i slept badish but i felt way more emotionally stable, so i tolerate the side effects. But yesterday i took Wellbutrin for the first time and today im starting to feel suicidal and wanting to self harm again whats going on????? That literally stopped since topamax
I have been feeling lonely, but ive been visiting family and its bearable, other than that no external factors. Could it be the wellbutrin?
Im seeing my psych today, but would love some opinions. Ty!
| 3 |
Best medication you have found for anhedonia (for example that can increase dopamine, other than Buproprion (Wellbutrin) and stimulants including modafinil)? And best medication you have found for severe anxiety including social?
|
I have TRD & treatment resistant anxiety, have been through countless diff types of meds. I am specifically looking for success stories with tricyclics, SSRI's other than Lexapro, zoloft, and prozac, and any atypical antidepressants or other meds used off-label. If you can please include a brief history/symptoms you suffered from, what dose it took to work (as maybe I didn't take a high enough dose), and how long it took to work, as well as any side effects you experienced. And yes I know individual experiences vary, I will take everything with a grain of salt :)
| 18 |
Question about Esctitalopram/Venlafaxine
|
Hi everyone, I suffer from ME/CFS and currently in a depressive episode. I'm on 100mg Lamotrigine which takes the edge off but is not nearly enough.
I was wondering if anyone who has been on either or both drugs can share their experience in regards to emotional blunting/anhedonia and sexual dysfunction these drugs cause. I'm willing to try any dose I can tolerate and give it enough time if these side effects do pass eventually or don't appear at all.
Thank you.
edit: Sorry for the typo in title.
| 5 |
How to improve antidepressant work?
|
Paxil
| 0 |
Glycine Unmasked: A Game-Changing Discovery in Depression and Anxiety Treatment
| null | 12 |
Anhedonia on all medications I have tried for depression & anxiety
|
Hi All,
I've experienced anxiety, depression & chronic pain for last 5-6 years. I have tried:
* Amitryptiline
* Pregabalin (PRN)
* Fluoxetine
* Diazepam (PRN)
* Duloxetine
The Amitryptiline was started to address chronic pain issues I have, but I feel like it helped with some secondary anxiety. Pregabalin was prescribed PRN when the Amitryptiline did not have the required affect - I didn't renew the prescription for this due to concerns with dependence on pain medication.
After an acute epsiode of intense anxiety, I was prescribed Fluoxetine & Diazepam, I took the former for approx. 18 months and sparingly used the latter in the first week to get me over the hill so-to-speak. I discontinued the Fluoxetine due to Anhedonia amongst other side effects.
The Duloxetine was started several months later, I took that for approx. 6 months and discontinued for the same reason.
I was offered Aripiprazole, but declined due to concerns about starting more medication I didn't understand completely when I felt in a rut with my current prescription.
​
I've been off medication for 3-4 months now, and feel like I've really fallen in to a pit of anxiety and depression. I know the things I am meant to do to help with mood, but I don't have the will to see them through. I am avoiding situations because of anxiety.
Does anyone have any advice or experience with medications that have not caused them to feel empty, numb, anhedonic etc. I feel like I need something, but what it is I'm not sure of.
Thanks for your time ツ
| 6 |
How long does memantine take to work? And experiences?
|
Hello, I got prescribed memantine. I started cautiously at 2.5 mg daily. Didn't notice much. Then took preworkout, and got way way high and sick, and remained mildly high for days. I later made a connection: it happend a few hours after I took my "stim free" pre workout.
Later I dropped down to 1.25 mg daily after a week off. When I took tyrosine, same thing happened. Tyrosine is in my pre workout. So tyrosine seems to majorly majorly majorly increase the potency of memantine for me.
So right now I'm wondering, do I continue with this mess, or call it quits with memantine? I have (probable) aspergers, and I get overwhelm and hypersensitivity in social situations, rendering me basically useless in those environments. Should I try it again?
| 3 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.