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how to properly get off nardil rn
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been on nardil 9 days, 7 days at 30 mg
how the fuck do i get off this med
| 3 |
ever since I started taking tianeptin I don't need to sleep anymore
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I have this diary where I record all meds I take and kcal I eat|
ever since I started taking tianeptin 17th this month, I noticed that I don't sleep pretty much at all, yet don't feel tired at all
I suddenly found myself interested in various things, and they consume me so much that I forgot about sleep
just yesterday I slept for about 2 hours, and only noticed today while reading my diary
the doctor told me to take one pill ever 3-4 hours. even taking one every 4-5 hours I end up taking 4-6 pills every day, which is probably more than I should
For the record, I don't mind the lack of sleep, but I'm afraid I'm taking too much
| 3 |
Recently started Wellbutrin and experiencing episodes of violent angry thoughts
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I recently got prescribed Wellbutrin and have been taking it for a week now. I've noticed that around noon every day at 12-4 I just get this thought of violence and misanthropy and extreme sadness that keeps me in my house for hours on end, sometimes it's something small that triggers me and other days it just came out of nowhere. Is this normal for the beginning stage or should I do something?
| 2 |
I am very sleepy all the time, like a zombie, every thought and motion is very slow, I don’t feel alert - which antidepressant should I consider taking / bring up with doctor?
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I am very tried / sleepy all the time, I don’t feel awake and alert, I feel 50% awake and 50% sleepy. Also, every motion and thought is so slow that family comment on it. I’ve seen every doctor you could imagine, had all tests and even seen psychologist (still seeing) who said I’m not depressed and it’s not clear what is going on. Right now I just want to treat symptoms because feeling like this constantly for years has made me non-functional. I have no energy to do anything and everything requires so much energy, even brushing teeth, taking vitamins, my brain doesn’t want to do anything but rest.
I have tried escitalopram but had to stop within two weeks because of severe constipation, it also dilated my pupils. I tried fluoxetine (prozac) for 6 months and it seemed to somewhat improve mood, reduce irritability and give a bit more of a push but it didn’t touch my energy levels. It did however very noticeably dilate my pupils and this wouldn’t go away even after months. Eventually, my mood flattened out and it became even harder to do anything so I had to quit the fluoxetine and I feel like I’m now back to where I was before but for I feel like I still have some of that flat effect (facial expression feels stiffer, it takes more to smile / show emotion than I can ever remember).
It should be said that I’m sensitive to caffeine and get heart palpitations, nervous, etc so I don’t consume this, I would like to avoid these effects with antidepressant of choice but at the same time I really need energy. I tried to be prescribed modafinil or ampethamines but doctor refused as the guidelines for prescribing those are strict and I don’t have any diagnosis other than ocd and social anxiety.
| 1 |
[ANHEDONIA QUESTION] - Should I stay away from SSRIs and SNRIs? How about Tianeptine?
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Hello
Unfortunately, I have been dealing with Anhedonia for over a year and a half now. I am basically bored with everything - Nothing to look forward to and nothing to enjoy in the present. I just don't seem to enjoy things anymore.
Filling my day with activities feels like a chore. Some days are better than others. Everything feels harder.
**Why did this happen - A few ideas:**
I am 29 - and have been exercising and eating pretty healthy throughout my 20s. So this can't be the problem.
A few years ago I had **half of my thyroid** removed due to a nodule - My TSH is now around 3 vs 1 pre-op, but I am supplementing to get my TSH back to how it once was. This could be a lead, but I've been supplementing for a few months now and can't see a lot of success
**Weed - PORN - MASTURBATION -** I had, for 1-2 years, a really bad habit of watching porn and smoking weed in the evening - and masturbating. For hours on end. 3-4 hours. Every evening. I gave up this habit a year ago.
**Nicotine -** Nicotine affects me differently. It's easy for me to quit smoking. I started smoking just before I started experiencing this anhedonia - I could feel my anhedonia growing 'stronger' the more I smoked. Weird. I gave up smoking around 4 months - still the same issues. Also smoking always made me anxious. First time I've started - fight or flight states when smoked
**I took** Aceylcysteine for a year - around 1.2g per day (this could lower glutamate levels but I doubt this is the case) - gave up on it a year ago
Can't think of anything else
**What meds did I try:**
My first med was **Fluoxetine -** Shortly after I started feeling like this. Took it for around 6 months and didn't notice any benefit.
Then right after I gave up on it, in **November last year,** I got on **Bupropion -** 150mg and sometimes 300mg a day. **Took this until March.** Didn't notice much to be honest.
**I have also been prescribed methylphenidate** which helps a bit but not a lot - I'm not taking it anymore because I don't want to fuck up my dopamine receptors even more.
\--------
I honestly don't know if I should pursue meds anymore or try behavioral activation; change my attitude towards anhedonia, do more CBT/therapy, and so on.
However, I've talked with my psych and I don't know - I keep hearing how **SSRIs and SNRIs** are bad for anhedonia because they themselves can cause emotional numbing.
Bupropion, as I said didn't help me.
My psychiatrist is open-minded and is open to suggestions but in our last session she recommended **Tianeptine.** This seems to be a weak agonist of MU opioid receptors which I can see it working, but I don't want to do even further damage and desensitize my opioid receptors.
I don't know honestly where to go from here. Any advice? Stories? I wonder if I should give Tianeptine a try - or try more meds, other SSRIS, etc.
Thank you :)
| 2 |
What made you feel joy, able to laugh and make jokes again?
| null | 12 |
What are some things that made you feel more like yourself (happier and without the heavy emotions) when you suffered from catatonic depression and anxiety
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What gave you your spark back and feel more like a person who has their shit together when depression and anxiety were originally pretty bad?
| 20 |
Does happiness ever feel like a drug?
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Is happiness just another drug?
Does the come-down from it ever feel like your soul being stripped of bits of hope?
Does the aftermath of happiness make you want to numb your brain so you can stay preserved in a state of induced ecstasy?
Does the desire to stay in that state make you self-destruct?
Can happiness make you feel small, meek, vulnerable?
| 5 |
nardil working well
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but the side effects are too much
my face is swelling and liver hurts
what are natural maoi options or what other maois can i try that won’t give me these issues?
| 2 |
Implants and mental health
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Is there any research on surgical implants and mental health and cognitive function? I had a titanium plate some screws and a nylon mesh in my skull for a fractured orbital. Have just been looking into whether those can adversely affect mental health, like if they leech into your bloodstream or something. Would not surprise me if things like artificial hip or something adversely affected overall health, I question the long term safety of some of the materials that are put into bodies
| 1 |
Individuals with naturally high norepinephrine
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So individual with high level of norepinephrine tend to have ruminating thoughts. I realize it has both good and bad sides.
Since I began taking bupropion my life changed completely. I went through a lot of realizations and wrote a lot of principles about life.
This wasn't the case with SSRI. They made me very reckless and impulsive. I realize they probably lowered the norepinephrine. I didn't introspect and did whatever I wanted to do. I got in a lot of difficulty because of that.
What I am trying to conclude is that it is possible that individual with naturally high level of norepinephrine might be more mature as they replay the events multiple times and they are alert / focused when they do so (high norepinephrine). They might be more inhibited in social situations, (worried about negative consequences).
| 9 |
Break the Stigma: Mental Health Matters
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According to a recent Gallup report, depression has become increasingly prevalent. Over 18% of adults, or more than 1 in 6, report being depressed or undergoing depression treatment. This represents a significant increase of over 7 percentage points since Gallup began polling on the subject in 2015. The survey also reveals that nearly 30% (3 out of 10) of adults have received a clinical diagnosis of depression at some point in their lives, marking a record high.
– Gallup report
Start a Conversation, Break the Silence
Mental health is a topic often left unaddressed, hidden in the shadows of society. But it’s time to change that. Just as we seek help for physical ailments, we must prioritize our mental well-being. In this article, we will explore the significance of mental health, the impact of celebrity disclosures, the factors influencing mental well-being, early signs of mental health problems, and the obstacles in accessing mental health care. It’s time to break the stigma and create a society that understands and supports mental health.
| 11 |
Rexulti 1 mg? (+ Effexor)
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**First my background then I'd love your layperson opinions**🙂❤
I've had partial response to effexor. My brain's been wired ever since I was a teen to require some kind of ssri (or in this case snri) to keep ocd/depression/anxiety/and mood swings at bay. I've been on one ssri after another or snri and they luckily produce a partial response, it's just none worked that better than the other
Diagnosis
Anxiety, Depression, OCD, AND at this point MILD spectrum schizoaffective disorder (i'll explain later)
**Rexulti 1 mg**
That being said I feel very grateful that I am trying Rexulti 1 mg. No, my doc is not a pill pusher, in fact I wanted to voluntarily "guinea pig" myself and insisted on Rexulti.
**We may be able to not only reduce what MAY be negative symptoms of my Mild Spectrum Schizoaffective** (at this point its mild spectrum) **BUT** perhaps **IF** **the ssri properties of effexor induced amotivation symptoms/blunted social life** (this is theoretical and my therapist technically said it could be a combo of both residual negative symptoms of schizoaffective, depression, AND my serotonergic antidepresssant blunting motivation as an unintended side effect)
**THEN the Rexulti might lift me out of those problems because of the pro-dopamine activity I'll get in my frontal lobe receptors, D3 receptors, and alpha 2 adrenergic blockade which means it disinhibits norepinephrine like Remeron**
It also may prevent getting what I refer to as "half-delusional thoughts/sensations" that come up if I'm under stress from things in my life that make me feel sad (lack of sucess with women wanting to date me or even just get intimate ;), lacking motivation to pursue my hobbies and get in that flow state, wishing my brain was more normal and I didn't miss out on my social life as a teen to young 20 year old) and a few other things I won't get into.
The result is I get sensations that I KNOW INTELLECTUALLY are delusional like feeling watched and I'm thinking to myself "that pesky amygdala and hyperactive mesolimbic tract on the paranoia paghways. It goes away 1-5 days later btw. Why cant my NMDA receptors regulate this better!" (I love getting nerdy with pharmacology)
**The Question**
I understand 1 mg of Rexulti is not the target dose for preventing future "half-delusions or fear resulting from realizing my brain is acting up to produce these paranormal sensations"
BUT
Is it possible even 1 mg of Rexulti can help the mood/antidepressant augmentation? I talked a lot about the delusional sensation tendencies but really I'm very focused on wanting the Rexulti to augment my antidepressant first!
I know on Abilify I see people on tiny doses like 0.5 to 1 mg who swear even that helped their depression/antidepressant, so it gives me hope.
Rexulti the most I know is that it latches onto D2 receptors stronger than Abilify and activated D2 at about 45% (autoreceptors and post synaptic) besides D3 (that's gonna be lower activation of 15% but at 1 mg its supposed to increase D3 density) (ps it may be even more potent than buspar as a partial 5ht1a agonist with some saying it may be almost a full 5ht1a agonis
1 mg Rexulti= 62% plus or minus 8% occupancy d2 receptors (auto and post synaptic)
Maybe theres hope for mood before i have to move uo to 2 mg (and deal with insurance again)?
I would LOVE it if it improved my mood even before i had to work up to standard antipsychotic doss
| 3 |
Aripiprazole as an adjunct to bupropion 150 mg XL - 1.25 or 2.5 mg?
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Hi. So, my doc is trying something new again and I was prescribed aripiprazole at a low dose, as an attempt to balance the anxiety out. I have started with 1.25 mg and don't notice many side effects, only mild tiredness/waking up during the night and slight restlessness (not akathisia so far).
From what I've read, bupropion slows the metabolism of certain meds down\*, making their actual concentration somewhat higher. If it is correct, I am wondering if I should increase to 2.5 mg or stay on 1.25? Avoiding any harsh side effects is a priority, but having the med do its work is no less important.
>\*Bupropion and its metabolites are inhibitors of CYP2D6, with hydroxybupropion responsible for most of the inhibition. Additionally, bupropion and its metabolites may decrease expression of CYP2D6 in the liver. The end effect is a significant slowing of the clearance of other drugs metabolized by this enzyme.
>
> CYP2D6 inhibitors increase aripiprazole concentrations to 2-3 times their normal level.
(Both from the respective wikipedia pages with cited studies)
| 4 |
Boiling Hot Baths
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It takes so much mental energy for me to take a shower when depressed. I’ve gone 2 weeks without.
But I started taking boiling hot baths every 1-2 days. Not even to clean myself. Some days I just lay there in the hot water soaking for an hour or two. It takes my headaches away and I just have to sit there.
The hottest ones are the ones I need to ease myself into slowly. The best is when I get out, it makes it easier to go back to sleep. Do be cautious though because getting out suddenly of the heat does make anyone dizzy and want to faint.
| 24 |
Treatment resistance
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All SSRI’s I have tried have caused me severe bruxism on day 1 of each trial and I have had to subsequently discontinue after not getting any relief. In the past I have used SSRI’s without issue but after discontinuing them and restarting, the adverse effects are too much. Although I do think when I did use them successfully, they did provide positive effects on my mood.
I tried atypical Buproprion (Wellbutrin) and while I had no jaw pain whatsoever it felt almost sedative and made me feel a little lower in mood than usual but I was also at an extremely low dose and it’s possible I needed a higher dose.
Should I try an SNRI or will that aggravate the jaw pain like the SSRI’s or should I try something different? Another atypical, a TCA? I am at a loss to find something to help with my low moods and depression and it’s making my moods worse to repeatedly fail every medication. :(
| 4 |
What supplements do you take on top of your antidepressant?
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I take high dose Clomipramine, Wellbutrin and low dose Abilify. Alongside those I take a vitamin B complex, vitamin d3, omega 3 and magnesium. I’ve read these vitamins/supplements are beneficial for mental health and can make your antidepressant work better. Anyone else?
| 8 |
Anyone Else Getting Severly Depressed When On Benzos?
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I only took about 0,2mg of Clonazepam this morning to combat anxiety. Yes it helped my anxiety, but damn it makes me so freaking depressed and apathetic , its horribly. Is there anyone else with similar experience?
| 11 |
Can ansofaxine（Toludesvenlafaxine） and mirtazapine be used together as a stimulant?
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Ansofaxine（Toludesvenlafaxine） is SNDRI. Ansofaxine（Toludesvenlafaxine） (the Chinese name) has a high binding affinity for serotonin, norepinephrine, and dopamine transporters and significantly inhibited the reuptake of all three monoamines- IC50 = 31.4 ± 0.4 nM for serotonin, IC50 = 586.7 ± 83.6 nM for norepinephrine, and IC50 = 733.2 ± 10.3 nM for dopamine in vitro (serotonin:norepinephrine:dopamine = 23.3:1.2:1) . Mirtazapine is a serotonin antagonist. Can they be used together as a stimulant?
| 2 |
Can 2mg Abilify feel much worse before it gets better?
| null | 5 |
Why Most Psychotherapies Are Equally Ineffective
| null | 6 |
Amitriptyline and Buspar
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I think this is going to be my next attempt. I’m currently trialing mirtazapine and starting to hate it. In combination with my other meds, it gives me too many side effects. I take the tricyclic for chronic pain and really want some anxiety relief. Ssri didn’t work for me. My dr suggested buspar because it supposedly also helps nausea and stomach issues, in addition to anxiety. Any thoughts on this regimen?
| 3 |
Lexparo vs Prozac for sexual side effects
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I know that everybody has a unique response to medications (etc etc) but.... has anyone here tried both Lexapro and Prozac?
If Lexparo causes sexual dysfunction is it likely that Prozac will also or is the incidence about the same?
| 1 |
Wondering which antidepressant is better and asking ChatGPT
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So, I started taking sertraline 5 days ago which I think is fine but I struggle with avolition and I was wondering if other SSRIs were better for that, in particular vortioxetine. My doctor would not prescribe anything dopaminergic since he diagnosed me with bipolar. However I have self medicated with selegiline in the past tho and I still take psychedelics and smoke weed regurarly without problems, I don’t think wellbutrin or a dopamine agonist would be a problem for me, i am thinking of convincing my doctor to change my diagnosis since he’s proving to be very collaborative
Anyway, I asked ChatGPT which one is most activating between the two (setraline and vortioxetine) and it replied:
“Sertraline and vortioxetine can have different effects on individuals, and the experience of activation or sedation can vary from person to person. However, in general, it is more common for sertraline to have activating effects compared to vortioxetine.
​
Sertraline (SSRI):
\- Activation: Sertraline is known to have a more stimulating effect on some individuals, especially at the beginning of treatment. This can result in increased energy, improved motivation, and reduced fatigue for some people.
\- Individual response: It's important to note that individual responses to medications can vary. While some individuals may experience activation, others may feel more sedated or experience no significant changes in energy levels.
​
Vortioxetine (Serotonin modulator and stimulator):
\- Activation: Vortioxetine is generally considered to have a more neutral or balanced effect on energy levels compared to sertraline. It is less likely to cause significant activation or sedation.
\- Individual response: As with any medication, individual responses can vary, and some people may experience changes in energy levels while taking vortioxetine.
​
It's important to discuss your specific concerns about activation or sedation with your psychiatrist. They can take into account your individual characteristics, medical history, and any other medications you may be taking to help determine the most suitable treatment option for you.
​
Remember, finding the right medication and dosage often involves a process of trial and error under the guidance of a healthcare professional. They will closely monitor your response and make adjustments as necessary to optimize your treatment outcomes.” END response
​
Is that true? I am still wondering if I am wasting my time and my libido trying SSRIs, and I am convinced I need pramipexole
| 0 |
Any way to reduce weight gain on mirtazapine?
|
Hi
Im taking wellbutrin mornings, topamax and lexotan (occasionally) nights. Shitty sleep, so my dr wants to add mirtazapine 15mg to help
Im already in the obese area, have issues with food in general, please, any tips or any way to avoid or reduce the weight gain side effect to it?
Im considering not even taking it, im so scared, last time i was prescribed it years ago it didnt even do anything (no sleep, no depression help), but id love any help to
avoid the weight gain as much as possible, thank you 🙏🏼🤧
| 3 |
I'm Seeing A Lot of Posts About Clomipramine
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Why is your doc prescribing this since it's for OCD. I've had poor luck with docs using anything off label.
| 7 |
Clomipramine, Amisulpride Antidepressants
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Any positive experience with these antidepressants?
Please Elaborate.
75mg clomipramine, 200mg Amisulpride
Diagnosed with Generalized anxiety disorder, Depression and Negative thoughts.
| 2 |
The Potential of N-Acetyl-L-Cysteine (NAC) in the Treatment of Psychiatric Disorders
| null | 23 |
My depression is finally getting better due to the combo of meds I’m on
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I’ve tried many medications in the past but none worked well. I’m finally on a combo of meds that is working for me. I take it for severe OCD and severe depression. I take 250mg of Clomipramine, 6mg of Abilify and 300mg of Wellbutrin XL. After being on this combo for 2 months, I feel great. I feel amazing, like I can breathe and relax and enjoy life like I used to. I’m much more happier nowadays and motivated to do stuff. If anyone has any questions please do ask.
| 10 |
Any experience with tianeptine?
|
So I've been on bupropion since last year, but it has wrecked my digestion system. I also have Crohn's, so I think the two are interacting.
I'm bummed because bupropion works better than anything I have tried before. I have motivation and energy for the first time in as long as I can remember. But I can't deal with the diarrhea and stomach pain.
My psychiatrist has recommended tianeptine since I no longer want to touch SSRIs. Does anyone have experience with this?
I'm also curious as to whether this is a drug that can be started and stopped and how long it takes to leave your system? This is mostly because I'd still like to occasionally take MDMA and from what I've read it seems like tianeptine kills that.
Thank you!
| 9 |
Duloxetine/Clomipramine & Persistent Diarrhea
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I was taking Duloxetine for over a year and had near constant diarrhea/digestive issues. I kept my physician in the know and just accepted it at the time because the medication was very helpful for my depression. I recently switched to Clomipramine and noticed that the diarrhea did not go away. While I know it's possible that I am having the same issues with this medication, it seems unlikely. I tried a few dietary changes such as avoiding dairy and am now trying some time without gluten.
Has anyone had longterm digestive issues with either of these medications and found a way to resolve or work around them?
The only other thing I could think of is mild persistent serotonin syndrome but that seems highly unlikely.
| 2 |
Lacking Purpose (TW)
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TW for suicidal ideation. I 100% understand if my post gets deleted. I'm posting this to anywhere I think I can find somebody, ANYbody who could give me some semblance of advice.
I'm a 24yo American male and I'm completely lacking in motivation and purpose.
I've always been a lonely and mentally ill person. Anxiety, depression, suicidal, etc. I feel very little positivity and joy. I lack the motivation for self-improvement and self-reliance.
Ever since my youth, I've never been much good at making friends. Was never a very social or motivated kid. I've seen it said many times that charisma and having connections are essential to success in life. I severly lack social skills/people skills and fear that this has crippled my ability to live a well-off life.
I suffered a mental/emotional breakdown in 7th grade due to the stress of the workload. I got diagnosed with Asperger's and spent proceeded to spend most of my time in the special needs classroom. I've suffered several breakdowns throughout my years as a middle and high school student. Lots of banging on walls, lots of crying, lots of screaming, etc. I was the stereotypical "psycho", the quiet loner kid with no friends and no social skills. I dropped out of several high-demand classes and clubs as a result of never being able to handle the workload/responsibility (APUSH, robotics, Beta Club, National Honor Society, etc.). I never took the SATs or anything like that. I feel horrifically ashamed and guilty and useless and worthless because I could never make it in these classes/clubs. It's resulted in me feeling constantly suicidal to this day due to never living up to my own hefty expectations of myself.
In 10th grade, I confessed how sad and angry and suicidal I am to a guidance counselor and it landed me a week in a juvenile mental facility. I wasn't allowed to return to school for half a year after that. I totally screwed myself even further. Shoulda just kept my mouth shut.
I'm still living with my parents and am totally dependent on them for everything. I never learned how to do all the things kids are supposed to learn. How to make friends, how to swim, ride a bike, etc. I'm 24 and I don't know how to drive! And as an adult, I know diddly-squat about insurance, homeowning, taxes, etc., or any other important adult stuff. I've been working part-time as a dishwasher at Cracker Barrel for the past 8 years, less than 20 hours every week. I still rely on my parents and grandparents to get me to and from work. I feel like such a massive burden and have attempted to take my own life multiple times.
Sis got accepted into college recently. She's absolutely amazing, an extremely talented and intelligent young woman. An artist, musician, writer, etc. Recently, I overheard Dad telling her how great she is while talking trash about me behind my back. Said I'll always be dependent on him and Ma. He's sick of it and moving out in September. I'm absolutely terrified of what'll happen to us once he goes.
I confided in Sis about what I heard and she told me she wanted to yell at Dad and tell him to shut up right then and there. That a parent should never talk like that about their child. She offered to help me learn how to drive and she offered to help me apply for college. But I'm so genuinely terrifed that I'll crash and burn in college (see my previous academic history of stress and mental breakdowns). I'm so, so, so genuinely scared outta my mind that I'll never make it. That I'll never amount to anything, so why bother accumulating debt if I'm probably just gonna drop out like I always do?
I've become hyper-fixated on the concept of euthanasia. Death with dignity, the right to die, etc. This suffering is just too much to bear. I'm so sick of myself. I wish I was normal. I wish I wasn't so emotional and outbursty. I wish I wasn't so socially inept and helpless. I wish I leaned how to swim and how to bike and how to drive when I was a kid. I wish I knew how to be responsible and own my own place and do taxes. I'm the type of person who needs firm directions from others in order to achieve some semblance of function. Can anybody give me direct and concise orders on what to do next? I can't do this alone...
I apologize if all this comes off as whining and complaining, I'm just so very sick and tired of myself. Seriously, what should I do? What CAN I do?
| 12 |
I have given up
|
I was training twice a day, 4:30 am and 4:30 pm hour and a half with cardio/bodyweight in the morning cold shower cooked protein breakfast skincare then my job and slow heavy weights in the evening followed by 4hours of studying, taking care of my home and a nighttime routine of hygiene and skincare nighttime i had warm showers and hypnosis right before bed. I felt that my routine killed off my depression. I had self respect. Stuff happened and I had a breakdown. I have a load of meds. I feel like everything I do is very slow, I take twice as long to do anything. I have gained 20kgs of fat and lost alot of muscle. It costs me more than my rent for the medication. Although I am just doing one day at a time I feel like crap.I'm still depressed and suicidal but very quiet about it. I don't want to go on that whole change up your meds until its a magic wand thing. I have financial trouble and I am just too tired. I'm unable to get back on my old routine. I can physically just not do it. My body feels like lead. I don't even know why I wrote this.
| 14 |
SSRIs make me more OCDy...
|
Since I take SSRIs I've become more obsessed with certain perfection seeking behaviours. Normaly SSRIs tend to abolish or at least attenuate OCD, but in my case it seems that I am getting more obsessive and perfectionist. I don't like it. It blocks me in taking productive and constructive action. I am wasting my time with unnecessary detail work.
Everytime I am on SSRIs (Sertraline, Escitalopram etc.)
Anyone of you experienced something similiar?
| 2 |
Does Clomipramine really work for OCD/BDD or am I just wasting my time?
|
So I was recently prescribed Clomipramine, I’ve been on 25mg for 4 days and will be going up to 50mg next week then possibly working up to around 200mg obviously under the supervision of my psychiatrist as I have severe OCD and BDD so the higher doses will be more beneficial. Does this anti depressant really work? It’s my last resort. I’ve been on every SSRI which for some reason I’m resistant too. I’m worried incase this doesn’t help and that I have to live like this forever. If this doesn’t work then my psychiatrist wants to add a low dose antipsychotic (which I DO NOT want) as I’ve seen what they can do to you. Thanks
| 3 |
How to get doctors to prescribe something that works?
|
My faux psychiatrist is very hesitant in prescribing anything out of the ordinary for standard prescription options. Where I’m admitted they’re overly worried for overmedicating even though I honestly need more than the standard shitty SSRI antipsychotic protocol, I’m in this deep depression hole for 3 years now and I’m worried since it’s taking way too much time of my life. I also want to start my career and built my life again. I have admitted myself to rehab to get better for a reason
Do you have to overemphasize your symptoms or act a certain way? I see that fellow rehab inmates get much more medication and they’re having anger attacks all the time, maybe I gotta do what they do ¯\_(ツ)_/¯
| 5 |
Is there anything I can take that doesn't go through my stomach? I have gastroparesis and gastritis...
|
I get sick pretty often when I take medication, it's kind of normal to react the worst that's possible, but I have an extra problem right now which I developed over the winter... After a gastroscope, I have recently been diagnosed with severe gastritis and mild gastroparesis. This means my stomach produces lots of acid and get's upset quickly, while also slowing down my digestion (including medications). It was so bad they originally thought I have cancer after I ended up hospitalized for a day and had drips and things put on me.... This could very well be an extremely long time to recover. I have been on medications for these stomach issues for nearly 5 months and the whole time I couldn't take mental health meds (besides gabapentin) and it's getting to a very severe mentally ill level... It all started with an unrelated antidepressant, which I quit and couldn't stop throwing up for weeks. Now I only throw up when I take medications. It could be caused by the medications, but more likely it's just extreme sensitivity from my stomach issues. I am expected to stay on my stomach meds for months to years from now, so I've been told....I just don't know, with the exception of the gabapentin that's I've been on for like 14 months, nothing stays in my stomach... and it isn't sufficient to keep me mentally well... Even my NP doesn't know what to do, because of this complication...
| 2 |
Abilify: did you lose the weight?
|
Since I've been taking Abilify (2 years), I've gained a bunch of weight. I went from a US women's size 2 to a size 10. That alone isn't the end of the world, but my bloodwork shows I also now have high cholesterol and triglycerides. I'm only 34.
I don't know whether it's worth it to stop taking it; it's been so helpful for my mental health.
If you took Abilify, gained weight, and then stopped taking it... were you able to lose the weight and bring your metabolism back under control?
| 3 |
After years of trying different regimens i have decided to go cold turkey on everything. What should i expect?
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After being on different ADs, augmentations and benzos for about 8 years, and not having slightest improvement on my condition only worsening i have decided to go cold turkey. Currently i am taking 300mg venlafaxine 15mg mirtazapine 5mg aripiprazole, and 2 to 4 mg clonazepam daily. My question to you who did this is what should i expect? Since nothing worked i guess withdrawal symptoms shouldn't be that bad?
| 10 |
To medicate or not to medicate
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I have been on Clomipramine 100mg, Abilify 10 mg, Wellbutrin 75 mg and Trazodone 50 mg on and off for about 2-6 months (insurance issues caused getting medicated to be a long process). I’ve been prescribed a few other things but this combination seems to help my OCD the best (also medication of bipolar, ptsd, anxiety etc). I no longer get thought loops and my depression has been minimal however, as of getting medicated, my head is just completely empty. I cannot study or read for my attention span is poor and my brain does not retain anything. This has impacted the things i love, like songwriting, my spiritual practice, and impacted school as well. I also cannot stop shaking which has impacted other things i love like exercise and yoga especially. What should I do? I know changing medications would help but I am so worried about just everything. I just wanna feel like me again, but i don’t want to be suicidal again.
| 2 |
finally getting peace! amitriptyline works for me!
|
i’ve been fighting anxiety and depression since i was about 5 or 6 years old. my pediatrician actually suggested putting me on antidepressants as a child to my mother and she declined for very understandable reasons. i continued to struggle until 17. i had a big mental breakdown and ended up on lexapro, risperdal and klonopin. it worked okay but i still ended up in the psychiatric hospital where they discontinued my lexapro and upped my klonopin to .5mg 3 times a day. i just remember feeling like a zombie. a few months after that, i had trialed other ssri’s and snri’s and they all made me feel like absolute shit. eventually my psychiatrist put me on amitriptyline. my mom is on amitriptyline and it works for her like nothing else. it completely saved her life so we decided to try it. i eventually got up to 75mg and stuck with that for about two and a half years. it was alright. but just went up to 100mg after a horrible depressive episode where i couldn’t eat or sleep. it took about two weeks but i feel much more levelheaded and rational. i still have anxiety but i’m able to deal with it like a “normal” person. i feel peaceful and relaxed. i’m eating and i’m sleeping. i could cry i feel so okay. my psychiatrist thinks my mom and i metabolize medication differently and that’s why tricyclics work for us. i’m still on risperdal and klonopin once a day but i feel like now i might be able to discontinue the klonopin! i hope i continue to see more benefits from 100mg since it is the therapeutic dose. sometimes the more unconventional options turn out okay :)
| 22 |
For those on low-dose Abilify for depression, is it true that there is a poop~out effect ? Or did it continue working super well for you?
| null | 2 |
Trintellix augmentation / add-on options?
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Just crowdsourcing any add on options to explore for anxiety and depression being treated with Trintellix (I got to this med through what seems like the usual pathway: Lexparo worked well but caused sexual side effects).
So far I've got buspirone (which I know will help with the anxiety more than the depression) and lamitcal.
I've previously tried Zolfot and Lexparo and both had basically the same side effect profile so... I don't think there's any point considering more of the "classic" SSRIs.
| 1 |
I have no sex drive, even without any antidepressants
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I have had this issue for nearly 5 years now, I literally have no sex drive. I cannot get into the mood and feel like I really have to put in an effort into anything sexual, nothing feels natural anymore.
I do not take any antidepressants because they don't seem to help my depression, this has just how I've been ever since I've been depressed. I avoid porn and can go quite a while without it but that doesn't seem to have any impact. It has really affected my relationship and I feel like a totally undeserving partner to anyone. Anything else I could try? Any stimulant or something that might help?
| 5 |
Has Anyone Done a Clinical Trial? I Have a Pre-screen Scheduled But Am Not Sure About it
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Like the title says, I saw a depression clinical trial ad on facebook and filled out the form. They called me and I met the criteria to move forward with an in person prescreen.
What are your thoughts about clinical trials?
| 2 |
Is the result of this study not credible?
|
Number of participants: 40
'After six weeks, 14 of patiens treated with sarcosine fullfilled the criteria for treatment response but only 4 out of 20 treated with citalopram'
Citalopram baseline: 24.5: Week 2: 20.3; Week 4: 16.3; Week 6: 14.0
Sarcosine baseline: 23.7; Week 2: 14.8; Week 4: 12.3; Week 6: 9.4
https://pubmed.ncbi.nlm.nih.gov/23562005/
-
If sarcosine was that superior to citalopram, I think there would be a lot more people talking about it on reddit. The result of sarcosine is so superior to that of citalopram that it appears hardly credible, however it should have been an impulse to replicate the research, which dates back to more than 10 years ago, because even if the result of this research is most probably exaggerated, it would be a big indication that sarcosine could have a significant antidepressant action, to be evaluated better. It is still the only clinical study involving sarcosine as a potential antidepressant. There is currently only one clinical trial of sarcosine underway and it involves sarcosine as an add-on to an SSRI.
| 4 |
treatment-resistant-depression advice?
|
sorry i can’t figure out how to search the sub to see if this has been discussed. i’ve (31F) tried 30+ medications in the last 10 years, the best ones working for maybe 2 years. i’ve had the greatest result from a combo of wellbutrin and lyrica, but it’s been just over 2 years and i’m miserable *again.* i’ve struggled with suicidal ideation for at least 13 years in a “i don’t necessarily want to die, i just want it all to *stop*” way and it gets louder and louder as my meds stop working. definitely have some ptsd and generalized anxiety; bipolar has been ruled out. recently became pretty curious about the possibility of FASD tbh.
i have a great psych (finally!) who loves a challenge and just switched my zoloft (miraculous for my anxiety until i tried to get off it and it broke me and stopped working; also too sweaty) to pristiq and i haven’t noticed an improvement yet but it’s only been about a week. i wanted to do ketamine and she was supportive of it buuuut it’s not covered by insurance. weed gummies are the only thing keeping me alive right now i swear, because if i get high enough my memory resets too fast for me to feel anything at all. it’s great but not very sustainable lol. i feel terrible for my fiancée because she’s stuck to this miserable person who can’t feel anything good. she’s so sweet and patient and good to me but i just wish i wasn’t like this.
any advice/ideas appreciated. (pls be nice i’m very fragile rn) thank you
| 5 |
Call for psychosis treatment overhaul after evidence of autoimmune trigger | Mental health
| null | 5 |
Glutamate Imbalance Impairs Hippocampus, Leading to Psychosis - Neuroscience News
| null | 9 |
Which Non-Antidepressant Drugs/Medications Are There That Actually Can Have Antidepressant Effects?
|
So for example, there is **Dextromethorphan**, a drug that is used to suppress coughing, but actually has antidepressant properties.
Then, there is, for example, **Gabapentin/Pregabalin** which is indicated in treating neuropathic pain, but can actually relief anxiety/depression.
Then there is **Vorinostat**, an anticancer agent, that shows antidepressant effects
Another example: **Glecaprevir and Pibrentasvir** which are drugs that are used to treat Hepatitis C are now investigated for their potential in treating PTSD.
So basically, I am talking about medication that is indicated to treat conditions that are very different to depression or anxiety, but actually have antidepressant/anxiolytic activity
| 4 |
For those that use a tincture or troche/capsule of medicinal cannabis for their anxiety/depression what ratio of thc and cbd helped them the most after trial and error?
|
Some of them set off my anxiety bad on my more insecure days
| 4 |
Help from Zoloft users. Are. a lot of you still taking the branded version of the drug and what is the best generic?
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Hi all. So I was on Zoloft years ago with success and plan on going back on the drug soon as the Lexapro I've been taking the last decade pooped out on me completely(20MG). It's been starting to feel ineffective over the previous 18 months to 2 years, and I'm just getting worse, and I need to do something soon. Anyways, my new insurance absolutely will not cover branded medications. I've had a bad experience with generics, particularly Lexapro when I was stuck on the generic for a month. I've been paying out of pocket these last few months for the Lexapro, which is astronomically expensive and putting me into credit card debt. Back when I was on Zoloft, I was on the branded version, and this time around, if I want this to work, it will have to be one of the Generics. I'm aware many different companies are now making Zoloft, and I'm just trying to determine what manufacturer's formula is closest to the branded version of the drug. Have many of you had issues with specific generic versions of the drug and not others?
Chances are I'm going to do a cross-taper from Lexapro to generic Zoloft, so I want my chances of success to be as high as possible. Any advice would be greatly appreciated as I'm in a desperate place right now.
| 1 |
If You Can't Remember if you took your meds, do you?
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[View Poll](https://www.reddit.com/poll/13fsgzn)
| 2 |
Is weight gain on Abilify even at lower dose like 1mg common ?
| null | 1 |
What causes you to see colors brighter and appreciate beautiful scenery?
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I'm trying to pinpoint what chemicals allow you to appreciate colors,if you see nice scenery in nature or in a picture and think "wow I'd like to vaction there," normally I look at the picture and feel nothing which is why I have no desire to take trips and am basically a hermit. I'm trying to figure out what chemicals in the brain make the world not black and white anymore.
I've experienced this for a short time while playing around with different supplements, but never able to sustain it. Then the next time I try the drug/supplement it doesn't work.
I've tried SSRIs, they for sure don't enduce this feeling, but neither does wellbutrin. I just want to be able to appreciate things, be able to say "wow that's a nice color" or "that's a pretty picture" rather than seeing everything and neutral.
Also has anyone taken an antidepressant that made them see in high framefrate? Like the TV's that have 120fps smooth motion feature? I've experience this briefly where everything is brighter and smooth, unfortunately it does not last.
| 1 |
Ritalin & Lyrica work brilliantly together for me!
|
Just sharing my regimen in case it helps someone!
I have persistent major depression with strong generalized anxiety. In addition to this, I have mild ADD and very high-functioning autism.
I take 27 mg methylphenidate (Ritalin/Concerta) once a day, first thing in the morning, with 150 mg pregabalin (Lyrica) at the same time. I take another 150 mg pregabalin in the evening, too.
I found that if I take methylphenidate alone, it turns me into an anxious mess, albeit a very awake and alert anxious mess.
But if I take it *with* the pregabalin, my anxiety, including my basal generalized anxiety, is totally resolved, and so is my depression. I'm feeling pretty good :)
Edit: feeling even better now that I've started HRT! But that's a tangential thing. If anyone is curious, I'm on 2 mg estradiol and 100 mg spironolactone.
| 15 |
It's confirmed 100% - For me personally, Mirtazapine makes my Depression 10x worse
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On paper, this makes zero sense, as Mirtazapine is indicated to TREAT depression.
My personal reasons for using it is to counter the sexual-side effects of SSRI, which it sure does work for.
But I've noticed that EVERY time I've been on it, for the next 2-3 days after last exposure, I become so suicidal that I actively research peaceful ways of ending my life.
When it's been out of my system for at least a week... those suicidal feelings suddenly just disappear.
I've tried this enough times over the last 5 years to know for sure that Mirtazapine is paradoxically making my depression worse.
And I think I finally know the reason why: There was a time when, instead of stimulants, I tried Atomoxetine instead. Whilst it worked, I noticed during that time that I felt severely suicidal also. I later read in a scientific paper that Atomoxetine should be used cautiously as it CAN indeed cause this side effect - and the reason is because it acts as a "partial agonist of the Kappa-Opioid Receptor" \[1\]. To put it in layman's terms, the Kappa-Opioid Receptor = the dysphoria chemical (ie. the polar opposite of euphoria).
And guess what: there's another scientific paper which shows that Mirtazapine is also a partial agonist of the Kappa-Opioid Receptor. Exactly the same way as Atomoxetine. \[2\]
\[1\] [Atomoxetine, ADHD, and the ongoing debate about increased risk of suicidal behaviors: the understudied role of kappa opioid receptor agonism Response to: Capuano A, Scavone C, Rafaniello C, et al. Atomoxetine in the treatment of attention deficit hyperactivity disorder and suicidal ideation. Expert Opin Drug Saf. 2014;13 Suppl 1:S69-78 - PubMed (nih.gov)](https://pubmed.ncbi.nlm.nih.gov/27283209/)
\[2\] [The atypical antidepressant mianserin exhibits agonist activity at κ-opioid receptors - PMC (nih.gov)](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504997/)
​
So if Mirtazapine is part of your treatment regime, and you're still feeling seriously dysphoric or suicidal, this is a potential reason why.
For me personally, I know I must avoid it permanently.
| 7 |
Evaluating a new digital psychoeducation ( everybody 16+)
|
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| 6 |
300 mg venlafaxine 15mg mirtazapine and 5mg aripiprazole and still sleeping 15 hours a day.
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So i am taking this combo which should be enough to wake up an elephant according to my psych, but it doesn't do anything for me. I read about Modafinil for excessive sleepiness. Should i add it in this combo?
| 2 |
How do you feel about atomoxetine?
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A friend gave me 20mgx3 atomoxetine. Took 20 yesterday and 20 today and I feel much clearer. I'm not sure whether or not to ask my doctor for a prescription because I'm already on a very interesting combo and am not too sure about contraindications. I know, not too smart to take it anyway but I figured 20mg was not too much.
I'm on:
200mg sertraline
1.5mg rexulti
50mg vyvanse
0.75mg pramipexole
I'm open to any other suggestions, thank you in advance
| 3 |
I’m hopeless and I feel I can’t trust the mental healthcare system to help me.
|
I’ve already been on three meds and I know that’s not a lot considering a lot of people try a lot more till they find the right ones, but it still makes me feel demoralized. First off it’s hard for me to even ask for help in the first place because of the depression itself. I’m a teenager and rely on my parents for healthcare. When they don’t take my problems seriously I kind of just crumple and fold because it’s already hard enough to get the motivation to even ask for mental healthcare.
A couple weeks ago my psychiatrist just told me to get a therapist ($$$) after me telling her my meds aren’t doing much at all.
Currently I’ve tried prozac and lexapro and have been on wellbutrin 300mg since november and it has maybe helped me a little. I wake up everyday completely dissatisfied with life. Life feels like a complete blur; akin to a dream because I have derealization. I’ve also showed symptoms of inattentive ADHD and executive dysfunction throughout my life. First remember experiencing SAD at the age of 9.
I don’t know what to do from this point on. There’s so much more to my situation I would like to explain, but I don’t want this post to be too long.
| 6 |
Is psychiatry, the only profession where they can fail over and over again and they still have their job?
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While I understand, we have a lot to learn with depression I just find it interesting how psychiatrists can fail over and over and over again upwards of 20 times and there be no consequences and they still get to keep their job. What other job could you fail that many times, and stay employed?
| 10 |
Has Abilify helped anyone with anhedonia / increased ability to feel positive emotion ? I know it’s a partial dopamine agonist…
|
Eager to hear your experiences.
| 10 |
Winter grumble
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First cold wet day here in the Southern Hemisphere and I'm having a yuck morning. Intellectually I know I'm as ready as I can be for winter but my primitive mind is going "hibernation sounds like a really smart option at this point."
| 3 |
2nd doc who refuses to prescribe Modafinil
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I am at a complete loss as to what is going on with these doctors. I recently saw a new psychiatrist and let him know that I am treatment resistant and all of the medication’s that I’ve tried and shared that I’d really like to use modafinil because it’s a class that I’ve never used before, and I do have extreme fatigue and exhaustion. During my appointment, he flat out refused to answer the question as to why I couldn’t try that. I literally brought it up five times. He then pushed very strongly on spravato, and I told him that I wasn’t ready for that just yet.
I followed up with an email, citing the studies showing how modafinil can help label for depression and the office reply was that he will no longer be interested in working with me, that’s that’s the reply.
I’m just at a complete loss is all I can say like how can you be in this profession and not even try to help people that have mental illnesses.
P.s. in my very first outreach to this practice, I specifically said I wanted to be prescribed a dolphin L or at least a Doctor Who is willing to try different things off Leyval. Clearly they didn’t read that correspondence. Complete waste of time.
| 5 |
Is there a way to tell which antidepressant works best. I’m on trial and error process with anti depressants and wish some anti depressants had more of an effect rather than just a way to manage your symptoms
|
I wish I felt stable more often and secure and happy while having my diagnosis of anxiety, depression, and bipolar
| 2 |
Has anyone fixed their depression with exercise/ supplements/ diet?
|
I’d love to hear any success stories!
| 18 |
sudden change in symptoms?
|
I’ve dealt with depression for about a decade now, I’m turning 23 soon and am AFAB. I know depression can cause both over and under eating, and I’ve always leaned towards the “over” side of that spectrum. But in the last month or so, foods I love (of which there are very few) just don’t interest me anymore. I’ve basically lost my appetite entirely, and I’m very hungry right now but all food just seems unappealing.
Is this a sign that my medication should be changed? I’m currently taking 250mg of effexor, and that’s been working well for me for the last three years (SSRIs didn’t help, this is the only SNRI I’ve ever been on).
Also, if anyone has any tips on getting yourself to eat when food doesn’t interest you, that would be greatly appreciated. I do struggle with a sensory processing disorder, and because of that I’m extremely picky about food—I basically live on plain pasta and cereal, and lately I don’t want those but trying new foods can be very stressful for me so I don’t know if it’s worth it to branch out if I’ll just end up disliking the new food as well.
Any help is appreciated, will answer questions if anyone has any. Thanks
| 0 |
How do you know meds are working?
|
So I know SSRI definitely doesn’t bring back good feelings (will rather do the opposite) but what about generally reducing negative feelings? What bothers me the most are casual uncomfortable day-to-day things, been taking Lexapro for almost 4 weeks, no sign of anything becoming more tolerable yet, so I should take it for 2 more weeks and call it quits if my situation still hasn’t improved?
| 13 |
Pharmacogenetic testing?
|
Hello there,
I’ve been depressed/anxious for years. Have tried a few medication regiments. My case manager is suggesting to have pharmacogenetic testing done to perhaps find a better fit faster. It might be covered under my insurance plan, so that’s why I’m considering it.
I would like to know, what is your experience with it? Has it helped achieving a right fit?
| 2 |
Is euphoria/giddiness normal on SSRI?
|
I’m not complaining, but have been on 10mg of lexapro for depression for a few months and starting to experience very elevated moods. It’s a bit bothersome bc there’s not necessarily a reason for it. Is this normal or could I be slightly manic?
| 2 |
Planning on starting TMS therapy soon for Major Depression and AVPD. Any advice?
|
I have been on Lexapro for over ten years, doing therapeutic Ketamine, but nothing is helping anymore. Lexapro pooped out on me last year @ 20 mg, and I planned on cross-taping to another medication. I was hoping something like TMS could help me through the rough patch of cross-taping an SSRI I have been on for a long time. Anyways, are there any effects negative or positive I should be aware of when going through treatment? According to research, it's usually 5 days a week for about 20 minutes, but you can drive after treatment. This is important to me since I cannot get rides and would still need to go to work afterward. Hopefully, the treatment provider is flexible with scheduling as I cant miss extended time from work. Also, how did it work with COPAYS? Did you require a copay every visit, once a week, or once for the entire treatment? Any advice would be appreciated.
| 8 |
Talking to employer re TMS?
|
I'm going to be starting TMS this week. Does anybody have any tips on talking to my employer about missing time for daily treatments? I work a pretty 9-to-5 office job with flexible hours, so getting the time shouldn't be a problem--I'm just anxious about asking for it. I'd rather not mention it's for mental health, if possible . . .
| 3 |
Is 200mg amisulpride low dose and good for depression?
| null | 1 |
Pramipexole work for anyone long term?
|
I'm hoping to find something to add on to my current AD regimen, having tried \*a lot\*. Pramipexole has seemed worth a shot in the past, but I've only ever read glowing reviews until a month or two later, when it poops out. Anyone found long term benefit from using prami for anhedonic depressive symptoms?
| 6 |
Papers on cannabis use and depression connections?
|
My therapist thinks one’s depression can’t get better whilst one smokes cannabis regularly (i.e. the minimum off time to get better should be approx a year). I wanna learn, so does anyone have opinions, sources to share?
| 13 |
Can I tell my psychiatrist that I think about suicide without being hospitalized?
|
I'm diagnosed with major depressive disorder by my GP and she has referred me to a psychiatrist because she suspects I have bipolar disorder. My psych appointment is coming up soon and I don't know if it's safe to mention my suicidal thoughts. I know it's probably a really important thing for them to know, but I'm scared of how I'll be treated if I mention it. I have never made a plan to do it but I think about dying more days than not. If I say something, will any good come out of it? I am really scared they'll try to put me in a hospital or something. I've never seen a psychiatrist so I'm really nervous about the appointment in general. Has anyone been through this?
| 16 |
I'm not depressed this morning.
|
Sorry if this isn't allowed here as it's not exactly a regimen, but I thought it was worth making a post to remind myself (and others) that depression can lift.
Last night when I got home from work I was depressed as hell, with zero motivation to do anything. Collapsed on the couch, zoned out to Netflix and didn't answer my phone. You know, the whole "dead inside", anhedonic feeling. (I know it all too well!) Of course when I'm in that state, I feel it will last forever, even if logically I know it's possible it will pass.
But this morning, I got up early, made myself some coffee and a healthy smoothie, and actually felt motivated to pick up my ukelele and sing. I'm NOT depressed, I want to be productive, and realizing this I also realize last night I was in a completely different headspace. Anyway, I'm going to take advantage while it lasts.
I'm on a Zoloft/Welbutrin mix, and I think it's doing something? Usually not to my satisfaction, but hey, this morning I just feel grateful.
At times I have wished I were dead, never existed, or that something or some one would kill me. This moment right now? I want to live. I feel connected to life, and so I thought I'd share this with you all. I commisserate with your struggles, and I hope the best for all of you!
| 25 |
I can't stop thinking about loss
|
(I'm not a native English speaker so sorry for my English)
For example I talk to my dad and I can't stop thinking how one day he's gonna be gone. Or I have a relatively good day but I can't really allow myself to feel any happiness, because a good day is not gonna last forever.
Recently I watched this video where a man that was suffering from depression said that "he saw all life events in term of loss".
[Here's the video](https://www.tiktok.com/@zermanzane/video/7032014625898073350)
Please somebody tell me that they can relate. I feel like it's such an underrated symptom of depression :c
| 3 |
Job lost due to antidepressants
|
Hey folks, I'm on the verge of 3rd job lost due to my anger outbursts and physical symptoms of schizophrenia. Currently I'm on Effexor 150mg, Luvox 50mg, Tegretol 400mg and Latuda 20mg. I've tried everything under the sun but nothing works. Shall I give up? Advice please
| 6 |
Psychostimulants (comparisons and LT fx)
|
Hello, dear Depression Regimen experts:
I am writing with a question(s) regarding the long-term use of psychostimulants. After a couple sever concussive brain injuries a decade ago, and living a very healthy lifestyle (by way of diet, exercise, sleep, meditation, relaxation, temperature modulation, time spent in natural world, nurturing relationships, etc., etc.,), for 10 years since, I continue to struggle with debilitating fatigue, a depressed mood, and chronic pain (among other challenging symptoms but these are the most notable). I have also tried every potential healing modality I am aware of (including both conventional and alternative therapies) except two rTMS and Ayuhuasca, both of which I am on waiting lists for. I have been using bupropion and modafinil for the past three years to manage my fatigue and mood; however, it seems as though modafinil is not working for me anymore (in recent months), given it is not helping with my fatigue and is giving rise to significant symptoms of anxiety that did not use to be present.
My doctor recently suggested trying some kind of stimulant (i.e., methylphenidate or amphetamine-based compounds) which leads me to my questions, which I try fielding to my doctor but I don’t believe she knows the answer to them (I am not sure if anyone does, which is why I’m trying here).
1) Is anyone aware of reliable information pertaining to the long-term effects of psychostimulants on the brain and/or other aspects of the central nervous system (preferably in adult humans but am open to stuff for any age or species if relevant)? I have concerns about the long-term effects of reward circuity (e.g., dopamine system); however, I do not know if these are warranted.
2) Has there been legitimate study about the neuro-toxic and/or -protective effects of these agents? And if so, do some medication classes appear to be more or less neuro-toxic and/or -protective than others (e.g., modafinil vs. methylphenidate vs. amphetamine salts (like Adderall) vs. amphetamine prodrugs (like Vyvanse)?
Of course, not wanting to waste anyone’s time, I have searched these topics to a decent extent myself and cannot seem to find anything over conclusively (maybe it doesn’t exist or maybe it’s out there beyond my reach) so I welcome anyone’s direction to reliable sources on the topic or original thoughts based on direct/personal experience.
Thank you, very much, in advance.
| 3 |
Guidance Needed
| null | 2 |
Waking up depressed and tired
|
Here it is Sunday morning and it’s a nice day which makes me feel guilty on the days when I just can’t leave the house. What do you all do when you wake up depressed and tired and have nothing scheduled for the day? I just can’t get myself going, especially if I have nothing to do like what’s the point.
| 5 |
Chronic pain causing treatment resistant depression?
|
**Treatment resistant depression**
I've had chronic back pain for the last 10+ years, and lived with it because no doctor could help me. I got anhedonia, depression and social anxiety around the same time. What I've tried so far:
* Classical depression treatment options didn't help (working with a therapist, cognitive behavioural therapy, EMDR, diets, meditation, self-help, yoga, sports, I have a good job, I have friends, overall lifestyle changes, having routines, setting goals, etc.).
* Antidepressants: Escitalopram (Lexapro), Agomelatine (valdoxan), Venlafaxine (effexor) didn't help.
* I got diagnosed with ADHD. Stimulants (Vyvanse/Lisdexamfetamine and Ritalin/Methylphenidate) help somewhat.
* What helped the most so far: weed, psilocybin, LSD, ketamine, MDMA, tramadol. These have the best effect. When I trip, I feel good and not depressed for that day, but depression quickly comes back the next day.
**Autoimmune disease diagnosis**
This April I had a flare up, and couldn't walk for multiple weeks. It turns out that I have ankylosing spondylitis, a genetic autoimmune disease which causes inflammation in joints and spine.
I'm now thinking: maybe I'm depressed because I've been living with chronic pain for the last decade? Maybe the drugs all act as pain killers and distract my mind from the pain? But depression quickly comes back the next day because I'm in pain again?
I'm now being treated for ankylosing spondylitis with Humira and Methotrexate. However, it will take up to 3 months for these medications to take full effect.
**Questions**
* Do you have similar experience with chronic pain and depression?
* How can I improve my depression/anhedonia in the 3 months until the chronic pain is treated at the core?
| 3 |
I took my second dose of armodafinil today ,so far no anxiety .will it cause anxiety after some days ??
| null | 1 |
my doctor want me to replace zofolt with effexor and I am scared of the side effects especially since he want me to up the dosege fast
|
I was prescribed 150 zofolt for two months then 200 for a month but it didn't do anything for me. now my doctor want me to replace it with effexor by tapering zoloft by 50mg a week and start with 75mg then increase it to 150 in the second week and 225 on the third week to not cause a relapse from tapering zoloft
after reading up on this subs and other in the last few days I am starting to think that reaching 225 in three weeks is too fast even if it's to replace another med. but at the same time I tried too many drugs in the last 12 years and nothing worked to fix my severe depression so I think the doctor want me on high dose since other meds didn't work
I am thinking of taking 75 for 2 weeks then 150 for 4 weeks then go to my next appointment first instead of upping it to 225 in three weeks only?
side note : I also started wellbutrin 150 xl in the last month and two days ago my doctor increase it to 300 since I didn't notice any benefits on 150
I need an advice before starting on effexor, is it worth a try if most others meds failed?
is it a good combo with wellbutrin?
should I go for 150 or 225 dose? I feel like 225 is too much for a start especially with strong side effects if it didn't work it will take ages to go off it
thank you in advance
| 1 |
Has anyone done a dopamine detox? Did it help?
| null | 1 |
Strongest SNRI?
|
Hi all,
A couple of years ago I (31F) stopped taking Pristiq (desvenlafaxine) and spiralled into a dark place. I was on Pristiq for 3 years and it was great for me. I was unsuccessful at going back on Pristiq though. I am not sure why this was the case, but I'm thinking a combination of drinking too much and increasing the dose too quickly. Because I was having trouble sleeping I was then transitioned to Mirtazapine. Mirt was helpful for sleep and appetite but not much else. I then added Lexapro (30mg). I've been on Lexapro and Mirt for about 1.5 years now but I'm still really struggling mentally. I've been through multiple rounds of psychology with not much success. So I'm planning in a few weeks to make the transition back to an SNRI. This has to work as my partner is losing patience with me and I fear that they will leave me if the transition isn't successful. So my question is, should I try Pristiq again or opt for something stronger? I have read that Clomipramine is the strongest SNRI available. I'm not sure if I should request to go back on Pristiq or try Clomipramine. Does anyone have any advice that could help me decide? My main issues are emotional regulation, excessive rumination, suicidal ideation, physical anxiety (chest pain mostly), insomnia and executive dysfunction. I'm unsure if these symptoms are due to undiagnosed ADHD as I do fit the criteria. But I was quite functional on Pristiq and I can't afford an ADHD assessment rn. I'll also add that I've tried medical cannabis. CBD oil only helped a little and it's too expensive. THC helps me sleep but it increases my physical anxiety symptoms.
TIA.
| 4 |
What's next for this med combo?
|
These have all helped me significantly in their own way but I still feel like the combo isn't perfect.
200mg sertraline
1.5mg rexulti
50mg vyvanse
0.75mg pramipexole.
I feel a LOT better than I used to, but I still kinda feel like shit lol. I'm doing therapy as well. I'm thinking either strattera or wellbutrin might be next but I don't know. I'm open to suggestions, thank you in advance
| 3 |
Lexapro 10mg has made me fatigued and gained 10lbs in 3 months-what else can I try?
|
Hey all. I deal with fatigue from chronic fatigue syndrome and long covid, but was managing it slightly better until they upped my lexapro dose to 10mg. I’ve also been steadily gaining weight despite reducing my calories massively-doing around 1400 a day.
What else could I consider trying? They said I have major depressive disorder and BPD but I think I was just bummed about getting a chronic illness so idk if an antidepressant could help that!
| 6 |
This might not belong here but want to see if anyone can relate
|
Do any of you have parents that never take your side on anything and are always playing devil's advocate. I am 43 and I am still dealing with this with my mom. Most recently it's about a new doctor who won't prescribe me a drug I really want to try (Modofinil) and instead wants me to do Spravato which I don't want to do at this point.
Instead of my mom getting behind me she says things like I'm sure the doctor knows better. Having had to defend my feelings and thoughts my entire life is just so exhausting on top of the exhaustion I already have from depression. I never feel that anyone has my back as a result of a lifetime of getting the devil's advocate from my mom.
Of course no parents is perfect and we learn this more and more as we grow up. But I can see just how much these patterns have created a lot of problems for me. At 43 I am the weakest, lowest, most insecure I've ever been. I wish I didn't need my parents support but I still do because I have 1 friend and not much of a support system.
| 8 |
Taking Mirtazapine and Buspirone together?
|
I was recently prescribed Mirtazapine to be taken once daily at night. I also have some Buspirone (5/10 mg) I'd like to take in the morning and early afternoon. However, I'm concerned about the risk of serotonin syndrome, as many sources online have warned of this. If anybody has taken the two drugs at once, did you find them helpful? Did you experience any negative side effects or serotonin syndrome effects? Thanks :)
| 2 |
Seeking feedback
| null | 1 |
About Meds for Social Anxiety
|
I can tell you that I'm suffering from depression and social anxiety since I was 15 (while symptoms occured in childhood already, I just didn't notice them in that time). I'm in treatment since I was 17 and with that trying to get rid of this illnesses, issues and suffering for years (now 23).
I tried like 14 different meds and 3 therapies (also CBT) already and I'm still suffering symptoms of depression and social anxiety - now it's just called treatment resistant depression, too. Plus my PDoc now even tells me, she strongly assumes that my mental health issues are of biochemical / physiological origin. I will add a list of the meds I tried in the comment section below.
So I wanted to ask you guys for an update in the world of meds for social anxiety. As said, I already tried many many many meds, but still I can't stop thinking about finally finding someone to stop this suffering and finally start living. On my list of "still to try" I still have a few meds, that you maybe have experience with regarding social anxiety (and depression):
**Antipsychotics:**
* Lamotrigine (Lamictal)
* Aripiprazole (Abilify)
* Olanzapine (Zyprexa)
**Anxiolytics:**
* Hydroxyzine
* Buspirone (Buspar)
* Clonazepam (Klonopin) - a strong one, I know, very addiciting but may be great if I'm able to only use them 1-2x a week max IF they even work for me, BECAUSE I already had Diazepam (Valium) & Lorazepam (Tavor) sadly didn't help much, I mean I felt the effects but I didn't really like them nor did they help my social anxiety or mood...
**Atypical:**
* Tianeptine (Tianeurax) - while this one can be addicting and I already have a kratom dependance
* Clonidine - which I could additionally need for getting off Kratom and finally forgetting it
* Lithium - I don't know why but my PDoc wanted me to try it but after one week thinking I decided not to cause I couldn't find any information about it getting used for non-bipolar depression or especially social anxiety (which is my main source of depression)
* Deanxit (Flupentixol & Melitracen)
**Antidepressants:**
* Nefazodone
* Clomipramine (Anafranil)
* Vortioxetine (Trintellix, Brintellix) - interesting as different being a serotonin modulator and stimulator instead of only serotonin reuptake inhibitor which never worked for me and I tried all the famous ones
* Fluoxetine (Prozac), Fluvoxamin or Desvenlafaxine - BUT as said all the other famous and typical SSRIs/SNRIs never worked on me, zero, and I really hate the side effects they can have and even be severe and permanent like PSSD, so I really don't want to try them again to be true
**MAOIs:**
* Selegiline (Emsam)
* Tranylcypromine (Parnate)
* Phenelzine (Nardil) - BUT sadly it's not available where I live (EU) so can't get it :(
**Don't even know about these, just saved them one day reading them somewhere, I guess:**
* Risperidone
* Rasagiline
* Amisulpride
* Tofisopam
* Trimipramine
* Doxepine
* Milnaneurax
* Pramipexol
* Ropinirol
* Mianserin
* Maprotilin
**Alternative therapies:**
* Ketamine therapy (Spravato, Esketamine)
* rTMS
* ECT
* Psilocybin or known as "Magic Mushrooms"
**Supplements:**
* Sulbutiamine, Memantine or Bromantane - WOW, these all have good reviews for social anxiety but I just can't find any information about buying them in my country or if they even are legal, just nothing to find, I guess they are not available and illegal in most of EU?
* Guanfacine
* Bacopa
* SAMe
* Tongkat Ali
* Polygala
* Cordyceps
* Lions Mane
* Skullcap
* Akuamma
* Wild Lettuce
* Kanna (sceletium tortiosum) - I tried it many times but only sublingually and it never worked, maybe really has to be insufflated to work?
***Any other suggestions for medication, therapy or any other treatment is more than welcome.***
***I'm really thankful for any kind of support or help!***
| 4 |
Wellbutrin 450mg: Can I have a little DXM, as a treat?
|
I've been depressed for 15 years and have tried over 20 different medications. Current medications are Wellbutrin 450mg, Trazodone 300mg, Remeron 30mg (which I have recently reduced to, from 45). Decreasing Trazodone not an option because I don't sleep without it (up for 6 days levels of don't sleep).
Still no relief, I've never consistently scored below a 15, and have been above 24 frequently since I moved here.
I meditate daily, run 5ks 2x-3x weekly, am in therapy and have done all of these for years. I don't eat hardly anything I haven't made myself and don't drink anything that's not coffee, tea, or water. 5'7" and 145 lbs currently.
I can't do anything. My apartment is a disaster, there was mold all over the dishes in the sink today because I never have the energy to clean it. I cleaned for 5 minutes and then gave up and went back to bed. I can't compose for any longer than a couple minutes at a time, and I couldn't even finish the consequent of a single phrase last time. I can't even finish single paragraphs of reddit posts. I just wind up looking at my phone for relief (it doesn't give me any) and scrolling between the same few apps through stuff I've already seen because I'm on my phone for like 6 hours a day.
I'm in TMS hell with no end in sight. I thought I was authorized, turns out that was just for the evaluation. I waited 3 months for the psychiatrist visit to get the referral and another month between then and now.
I need some relief *now*. I am *out of time*. I'm already so far behind every other 26 year old and I'm not even paying my own rent without my parents' help. I just want to be able to set a goal and achieve it. And I'm not talking "win a Grammy" level goals I would like to be able to do the dishes and do my laundry and not have a nasty apartment. I just want to be able to sit down and compose for 2 hours, I would take 2 hours at this point.
Only thing keeping me here at this point is my boyfriend and my mom, who is very understanding and supportive, but lives 1200 miles away in a state that is currently doing a bit of a genocide against people like me.
I currently have absolutely no hope that anything will ever work because I mean, just look down below.
I guess my question is, I picked up some dextromethorphan with my Wellbutrin because of the Auvelity meme right now, would taking a bit of it with 450mg of my wellies fuck me up, or can I do that? Does anybody have any experience doing this?
Latest list is:
SSRIs:
Paxil
Lexapro
Zoloft
Prozac
SNRIs:
Effexor
Pristiq
SARIs:
Trazodone
Atypicals:
Wellbutrin
Remeron
Mood stabilizers:
Lamictal
Anticonvulsants:
Trileptal
Antipsychotics:
Abilify
Seroquel
Geodon (briefly?)
Benzodiazipines:
Restoril
Klonopin
Stimulants:
Adderall
Focalin
Concerta
| 10 |
Sleep deprivation helps
|
I know that sleep deprivation is not sustainable but staying awake all night does alleviate my depression. I discovered this after a red eye flight on which I didn’t sleep and then staying awake the whole next day.
Since this isn’t something that can be done regularly (or can it??) what would be some other potential options for me? Thanks!
| 10 |
SSRIs work temporarily
|
I’ve been on a lot of SSRIs. Most of them. They have all been the same, whether they’re supposedly “stimulating” (Prozac) or not. What happens is - they work for about a month. I have energy, motivation, anxiety is gone. This is initially, after a few weeks of side effects, and also when I increase the dose. But after a month or two, I start to feel numb, exhausted and apathetic.
But this ALSO happens when I decrease the dose. The same thing - energy, motivation, maybe a little anxiety returns but it’s manageable. I feel okay… Then a few weeks later I start to feel depressed again.
It’s an endless cycle where I only really feel good for a few weeks, when going up or down in dosage, and then the doc switches me to to some other SS/NRI which does the same thing.
Does this sound familiar to anyone else? Does it suggest that any other particular med might work for me?
I did try adding Wellbutrin to lexapro at one point but it didn’t seem to help, and in fact I was pretty tired on it.
TIA!
Edited to add meds I’ve tried -
Prozac
Zoloft
Lexapro
Celexa
Mirtazipine
Effexor
Viibryd
Wellbutrin
| 5 |
Mental imagery is more helpful than "verbal" thoughts in distracting teens from negative thought patterns
| null | 11 |
It takes time ...
|
I slipped into a black space after fighting it for several months in early January. I had been trialling Wellbutrin without any other meds.
Between menopause and having to leave an extremely toxic work environment I was also struggling with body changes and some old trauma about bullies.
It's now in early May. I'm back on my old faithful Effexor at 150mg and I am day 21 of using 150mg Wellbutrin. I am also taking Magnesium glycinate and fish oil. My doctor also moved me onto estrogen patches rather than tablets and I'm at a lower dose than we would predict.
I have posted about having anhedonia pretty much solidly from early January through to mid April. However I took a very radical approach to dealing with it and started doing things I used to enjoy so I didn't remain isolated. I am blessed with good people in my social circle who "get" that I'm struggling and let me be present without expectations.
While I'm still working on task initiation (yes, likely undiagnosed ADHD, but almost impossible to get a diagnosis here as female, adult, and professional)
lots of other things are falling into place.
It has taken 5 months of consistency and self care and taking my meds, not disrupting their impact with alcohol.
I could not do this without an amazing partner who has learned to "hold space" when things are dark. I don't have a therapist but I've found the videos on Therapy in a Nutshell on YouTube very thought provoking. I also have professional supervision and my supervisor is good at "reality checking" me.
I'm not cured and don't expect ever to be, but I am 90% there!
| 6 |
Easy/fun exercise for depression?
|
I'm starting to feel a lot better after some new meds and lots of patience, but I'm still insanely physically unhealthy after years of just being so depressed. I want to be more active, but I'm still so unmotivated and fatigued. I want to find some exercise I can do that's easy to start and is actually fun. I'd love to do weightlifting one day but it's just not reasonable for me right now. I hate jogging, walking is fine but I get tired, and I can't join a gym for financial reasons. I want to find some exercise that doesn't feel like exercise and is just *fun.* Like a sport or group activity but I'm having a hard time finding a group. I like swimming, some group sports (ultimate frisbee, basketball, volleyball), dancing, and boxing. Also, I live in NYC so if there's anything specific there I would really appreciate it.
| 3 |
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