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Have you found anything that helps with critical thinking?
|
I know a substance can't make you think critically, but a substance can help the mental faculties that are needed for critical thinking.
I would guess that medicines that induce solemness can improve critical thinking.
| 13 |
Feeling constantly like a 90 years old. Tried many meds. It's a constant fatigue and frailty. Can't do anything!!!! Lie in bed all day long!!!
|
I tried many stimulants and meds so far:
1. 300-450mg Wellbutrin XR - giving me anxiety mostly and a very little bit of energy/strength and in two-three days stops working.
2. 30/60mg Adderall XR/IR - The most helpful one, but after a few days, feeling sick like I want to vomit on it.
3. 2mg Nicotine gum - Just relaxes me, but does not provide energy or strength.
4. Vitamin D - I tried to take it for two days, it doesn't seem to provide much of anything
5. Caffeine - The most helpful one, but loses efficiency after a few days.
6. Ritalin/Concerta - Just relaxes me, but does not provide energy or strength.
7. 1500mg liposomal glutathione - I tried to take it for 3 days, it makes me feel a bit drunkier, but does not provide any energy or strength.
8. SSRIs, SNRIs, Clomipramine, St. John's wort - does absolutely nothing.
9. Nardil - somewhat made caffeine to work again, but had to go to E.R. after at some point I couldn't pee
10. Lamotrigine - does absolutely nothing.
11. Memantine - somewhat helps lower tolerance of caffeine and Adderall, but clearly not enough.
12. DXM - somewhat helped lower tolerance of caffeine and Adderall, but clearly not enough, and after a month completely lost it's efficiency.
13. S-Ketamine - Used it in a therapeutic setting in a clinic, did nothing with regards of energy and strength. Made me to feel very tired after a session for the rest of the day.
14. Modafinil - extremely weak
15. Vyvanse - Did much at first, but now doesn't do anything. Probably due to built tolerance.
My psych doesn't know what to do with me. Please help.
| 12 |
Not sure what’s going on with me.. need help/advise please
|
Hello! New here. I’m 34, mom of 5 kids under 10 years old, married for 11 years.
I’ve battled anxiety sporadically throughout my life. The worst bout was 8 years ago after the birth of my 2nd son. I had debilitating health anxiety, racing thoughts, lost so much weight, etc. got on lexapro and it helped SO MUCH. I tried getting off of it for a couple months while pregnant with 3rd son and it was a bad idea. Got right back on it and was on it ever since.
Fast forward to the end of 2022/beginning of 2023. We’ve experienced huge financial hardship and lot of family drama with extended family members on my side which was hard in every aspect of our life. I finally realized in April I was very depressed - lack of motivation, lack of focus, trouble completing tasks, not looking forward to the things I normally look forward to.. got in touch with a psychiatrist and counselor. My psychiatrist thought maybe I’ve grown immune to lexapro and recommended Wellbutrin. Tried Wellbutrin for 21 days and did not like it. Hurt my stomach, wasn’t helping my motivation or attention span, etc. she thought about trying Effexor or Wellbutrin with a mood stabilizer (forgot name) or trying adderall for ADHD. Ive had ADHD tendencies practically since elementary school but I’ve never pursed diagnosis or treatment. I’ve enjoyed having a sex drive back and experiencing some new emotions that were dormant for 8 years while on lexapro so we went the adderall route. It really hasn’t done much for me at all and now I just don’t know what to do. I tried it for 6 days and we tried different times and doses. It didn’t really motivate me or help with attention/focus. I had 10mg tablets and we tried variations and the most I tried at once was 15mg. Now I’m really leaning towards really needing to tackle this from a depression standpoint.
I’m hesitant to try Effexor because I hear there’s some nasty side effects and withdrawal side effects.
My questions if you’ve read this long - 1. Does is sound like depression or adhd? Or both? 2. What would you recommend I do moving forward? I feel hopeless and defeated 😩. TIA
| 3 |
What could I try next?
|
About me:
* 30 years old
* US
* Non-binary (AFAB)
Diagnoses:
* Persistent Depressive Disorder
* Autism Spectrum Disorder
* Other Anxiety Disorder (essentially, I'm not a "worrier," but rather get somatic anxiety symptoms)
* Other Feeding and Eating Disorder (restrictive)
Medications I've tried:
* Zoloft (prevents SI, but results in anhedonia and low libido)
* Lexapro (no response)
* Pristiq (caused significant weight gain)
* Buspar (no response)
* Lamictal (no response)
* Abilify (no response)
* Ketamine, IM (very sensitive to dosage but a big lift in mood, but only lasted 1-2 months)
Current medications:
* Wellbutrin XL 150mg (I've tried increasing it to 300 but I get heart palpitations)
* Trintellix 15mg (seemed to work for \~3 weeks, but now I'm getting no changes)
* I'm also on oral birth control and low dose testosterone gel
Priorities:
* Increased mood, decreased anhedonia, increased energy
* No weight gain side effects (very important due to body dysmorphia and gender dysphoria)
* Few or no sexual side effects
I'm currently asking my doctor about switching to Auvelity because I responded well to ketamine. I'm also considering TMS and daily low-dose ketamine (Joyous). Interested to hear others' thoughts. Thank you!
| 6 |
Help with the bad funks?
|
Hi Everyone,
I am 35 year old female that has been on Lexapro 10 mg for 2.5 years. I have experienced depression since I was about 8/9 years old and Lexapro has definitely been a huge help for me. I notice lately, I tend to get depressed or in a funk after some really good days, like a vacation, or people visiting me, etc. and then I am sad/down and unable to do much that makes me feel better. Just looking for some coping mechanisms. I don't want to increase or change meds, as I feel like this is more situational for me - I live alone, I'm single, not loving my job right now. I just want some strategies to help me get out of these funks/avoid them altogether, or just some support. My last funk was Friday-Sunday and today I feel great, like the haze has lifted. Thanks!
| 2 |
Switching Effexor to Paxil
|
Hello I switched from 300mg Effexor to 60mg Paxil last week. I don’t feel a difference. Effexor stopped working after three years can I still expect things to improve?
| 3 |
Combining NAC with Saffron extract to combat anhedonia and intrusive thoughts?
|
I’ve been reading a lot about Saffron extract and NAC individually, both sound very interesting, but I haven’t found anything how well they’d work together.
SO FAR:
For the past decade I’ve been going back and forth on various SSRIs and Wellbutrin, but neither seem to get me out of my anhedonia and intrusive thoughts that make it hard to work, keep a consistent schedule, which in return creates anxiety.
SSRIs (Cipralex, Zoloft, Citalopram) side effects profile disagree with me (libido issues, makes me a yawning zombie, blunted emotions, brain zaps when discontinuing them). But from the blood work I had done, residual Serotonin does seem very low). On the plus side, although the initial side effects aren’t worth it overall, they keep me slightly more balanced.
Wellbutrin XR 150mg (until recently for the 5th time). The positive effects are very subtle overall, but I don’t want to go to 300mg, as I find the increased sweating and anxiety that gives me slight brain fog too annoying on the 150mg already. On the plus side, I really like the vivid dreams and how my libido is on it.
The general problem is that I suffer from mild to medium depression and whenever I want to do something about changing my situation, which is always stress-filled due to the years of procrastination, any bit of extra stress, like learning a new skill or solving problems, usually causes stress to spike to the point of brain fog and exhaustion. So I’ve been spending a great deal of the last few years with dopamine releasing distractions, to the point where I feel I need a restart in order become my old self again, who could keep himself busy acquiring new skills or practicing existing ones.
TL;DR:
Could NAC and saffron extract work as a milder anti-depressant combo that gives me the same benefits SSRI’s and Wellbutrin have without the side effects profile? Are there any interactions I should concern myself with?
| 2 |
Most commonly prescribed antidepressants in the US? Anyone know of a list?
|
Hello!
I'm wondering does anybody know of a resource outlining the most commonly prescribed antidepressants (and pharmaceuticals in general) in the US for (say) 2022?
I'd imagine that this information might be available by aggregating data from various insurers and/or perhaps at the state/federal level.
Purpose: for an article that I'm writing about AD prescription rates (specifically I'd be interested in seeing a ranking of each SSRI, TCA, and MAIO by prescription rates written per year ... and I'm assuming - possibly incorrectly - the US has the best data).
| 1 |
Eye Pressure and Depression?
| null | 3 |
How to tell my doc I got off this med?
|
My doc prescribed me Mirtazapine (Remeron) & Pregabalin (Lyrica) for months now. I took the Mirtazapine like a year ago but tapered it off months ago by myself as I thought it made me more stupid (which I still feel like, even after half a year off it). Withdrawal was okay, no big issue other than maybe a week of bad feelings and no sleep/no eat.
I never told my doc that I tapered it off by myself cause she had this medication plan and I really liked the Pregabalin which still helps me a lot (if I don‘t take it daily).
I now was 2 months unable to visit my doc cause my insurance was expired. I want to use this as an argument that I got off the Mirtazapine by myself and just used Lyrica as needed (amazing that the Lyrica she gave me lasted that long cause I really thought that I was going empty when I took it daily for some time).
What should I tell my doc? She will be asking what I have done these 2 months not insured and visiting her and not having any prescription of new Mirtazapine. I don‘t need the Mirtazapine cause I don‘t want to worsen my cognitive issues and I sleep and eat better now even without it. It was a good med but I don‘t need it anymore - at least right now.
I thought about just telling her that I either tapered it off by myself in these 2 months „cause I wasn‘t insured anymore and worried“ or that I asked my doc in my home country or my grandpa who‘s a doc how to taper and got off of it by that = how I was able to be 2 months without new prescription and never contacting her (I really didn‘t cause I was really not in a good mood, depressed, no drive).
Now I want to go to her cause I soon need a new lyrica prescription but also wanna try new meds for my mental health.
What would you do? How could I tell her that I was able to not needing to contact her and got off Mirtazapine / don‘t want or use it anymore?
| 4 |
What does the right dose of strattera feel like to be you?
|
I'd like to know what the right dose feels like to you. I know with vyvanse I say that if it makes me feel normal the dose is perfect but if it makes me feel stimulated the dose is too high, and it's a very fine balance that even 10mg can change. I was wondering if there are any similar anecdotes about strattera. Thank you
| 1 |
3 Month Parnate Review
|
I suffer from various mental illnesses relating mostly to OCD which caused treatment resistant depression.
From the first month onward of Parnate I've been in complete remission of my original anxiety. It's taken more energy to get used to being 'normal' than I imagined.
It has saved my life, I take 60 mg when I wake up in the morning and another 30 mg spread out no later than noon. Side effects are maybe somewhat worse than Zoloft but I'll take all the benefits over the side effects even if they were twice as bad. I struggle to think of a specific side effect that bugs me consistently other than constipation and weirdly I wet the bed twice when increasing the dose too quickly.
If anyone has questions please ask I felt keeping this short would be best since I doubt many will really read much longer than this.
There's hope don't give up until you find a doctor willing to try all the medication there is out there that can help that many doctors either are ignorant of or too scared to use. Wishing everyone well.
(I also take 1 mg guanfacine daily)
| 5 |
I just wanted to say I'm at FULL REMISSION!!!! I'm so happy with life right now and wanted to share my story along with what helped my depression the most.
|
Hello all, I'm pleased to be writing a positive post here for once. All my previous posts have been about finding medications and methods to deal with suicidal thoughts. Well, its been about 2 months since I've had a suicidal thought. I love living, and I don't want to die anymore. I haven't had a single negative thought in the span of these last 2 months. I don't believe I suffer from any depression anymore as well. Before I go into what worked for me, I'd like to describe how my mental health used to be. I was dealing with very, very intense suicidal thoughts for 6-8 months. These thoughts occurred every single day, and occurred almost every single hour. Life was so incredibly dark for me, I'm surprised I didn't lose myself in the process. I would wake up and think about killing myself. Before sleep, I would pray for my life to end. When I was hanging out with my friends, random suicidal thoughts would flood my mind. I hated everything and everyone. However, more importantly, I hated myself. The mental state I was in was so disgusting it's hard to describe. Having so much hatred, disdain, and disgust toward everything and everyone was incredibly unpleasant and made life hell.
**The change:**
Medication: The lord and savior of mental health issues, medication. I've trailed and errored so many different medications I almost gave up on them. Besides trying a boatload of different anti-depressants (typical and atypical), I also tried various other things. These things include ketamine infusions and ECT. Neither the medications nor the ketamine or ECT helped. ECT was actually discontinued after the 4th treatment due to the side effects being unbearable. However, I started to see a new doctor that was very nice and willing to try multiple different medications for the sake of my health. What really worked the most was the following: Lithium carbonate 300mg, Effexor XR 37.5mg, Modafinil 100mg, and Methylphenidate 18mg. This combination of medication helped a LOT.
Lifestyle: By far the biggest changes to my mental health occurred when I started studying 4 hours a day and reading 1 hour. I started studying for my CCNA certificate and I was reading whenever I had the time to do so. I worked 35 hours a week so I had plentiful time to read and study. I did this everyday for about 4 weeks. During the end of my 4 weeks, I got a new remote job! Working from home has improved my quality of life significantly. It also helps that I actually don't mind my job one bit. In the past, I used to hate Mondays. However, things have changed, and I actually don't care when my weekend ends. I really don't hate my job one bit. It helps to do work you're good at and that you find rather easy to perform. I also adapted a different mindset entirely on my mental health. Instead of wishing to die, I wished to live. I started to get mad at the fact that I wanted to die. If I was givin this incredibily rare chance at life, how pathetic would it be for me to kill myself? Why not TRY to live my life to the best of my ability. In an infinite timeline, I better do my best to make something out of my life. I now have an entire career path and goals I've laid out for myself. I know exactly what I want out of life and I also know that I'll obtain said goals.
Sorry for the longish post, I just wanted to share my exciting news! Thanks to everybody in this sub. This is by far, the best depression sub in existence. It isn't an echo chamber of negativity and suicidal stuff like other subs on reddit. This sub aims to help those and uplift them as well. I hope you all get better and find worth in life. If I can beat my previous mental state, you guys can as well. I went from wanting to die everyday to wanting to live :)
| 59 |
Struggling with burnout-induced depression, implemented a bunch of healthy habits, but still heavily traumatized by work. What should I do?
|
Hi all! I'm an entrepreneur, and after a couple of years of burnout, my condition has significantly worsened two months ago, and I've been diagnosed with moderate to severe clinical depression. I've been having an indescribable feeling of sorrow, anxiety, apathy, helplessness and emptiness; in the first week of the whole episode, it was even hard to get out of my bed. For the past two months, whenever worked (or even just thinking about work), I would experience immense anxiety, fear and (sometimes) anger, as well as physical symptoms, such as massive headache, body tremors, and faster heart beats (and one time, almost hyperventilating). As a result, I've not been productive at work and in every sense of the word, dreaded it.
I've been taking some time off work, been in therapy and implemented new habits (living healthier, through exercise, diets, sleep, meditation), but recovery has not been linear (some days are better, some days are worse), and the anxiety and fear around work remains. The trauma around anything remotely related to work is real -- I still can't open/reply email, or think of anything/anyone around work at all -- all of these give me tremendous fear and anxiety. I've been totally offline for the better part of the last couple of weeks, but got an urgent update that a commercial deal we had been working on had fallen through, and it may have dire business consequences. It's hugely upsetting because I had hoped that the company (my business partner and the rest of the team) should be able to take care of these things without me, and it doesn't seem to be that way. Things at work are obviously worse now, and I won't be able to go back to work peacefully.
Right now, I'm just feeling a whole range of emotions -- sadness, anxiety, fear, helplessness, emptiness, anger and resentment. Maybe it's the depression speaking, but I've been thinking -- I've dedicated so much of my time, effort and personal resources into the company, and it seems that no one in the team (including my business partner) was as committed as me. At this moment, I want to prioritize healing, and even then, I'm not able to fully relax and recover. A part of me want to just abandon everything and focus on healing, but I'm too sad and anxious to even do anything remotely related to work.
Apologies for the long post, but I've been feeling so sad and lonely, and advice of what you would do, would be hugely appreciated!
| 11 |
What got rid of your anxiety/depression and gave you the motivation to face each day again?
| null | 10 |
Pristiq -> EMSAM (patch), Anyone make a similar switch for TRD?
|
Right now I'm trying to come off Pristiq 100mg and Buspar 15mg TID so I can try to switch to Emsam. I'm down to 25mg of Pristiq, but feeling really fatigued and anxious.
Has anyone switched to Emsam, and if so how was it? I'm worried that it may not help with anxiety. It seems to lack any serotonergic action at low doses, so maybe I can keep the Buspar?
| 2 |
Depression's Immune System Connection - Neuroscience News
| null | 5 |
Giving up on treatment
|
Hi folks. I have long history depression and anxieties. Tried everything under the sun but nothing works. Anger outbursts, weak personality, job losses, survived everything. Currently on Effexor 225mg, Luvox 100mg, Divalproex Sodium 500mg. Wanna give up on all the pills cold turkey. Any advice please
| 9 |
I don’t want to go back to therapy. What do I do?
|
**TW: suicidal ideation**
Long story short, I cut things off with my last therapist after she sent the police to my apartment because I didn’t respond to one of her messages in 15 hours. I was at work at the time, but apparently the police scared the shit out of my roommates and were banging on the door. Now my roommates know I’m suicidal as well (they knew I was depressed, but not how severely). Honestly, the whole event shattered my trust in therapy and now I feel genuinely frightened to go back.
**The next two paragraphs are just pure venting, TLDR is at the last paragraph. I’m sorry for all the text.**
Ever since I disclosed my suicidal ideation to my therapist it felt like she began to trust me less and less. I repeatedly told her that I have never had any actual intention to hurt myself and that I have never developed any plans, which is the truth. I told her that while I might indeed feel a constant, strong desire to end my life and put a stop to the pain, a desire is all that it’s ever been and it ever will be for the foreseeable future, unless I completely lose my mental faculties. The one and only thing I am truly committed to in this life is to avoid hurting my mom, so I swore to myself that no matter how difficult it gets, I will stay alive as long as she is alive. I will wait until she is no longer here to die. If I can’t even do that one thing, if I can’t even fulfill my one commitment in life and protect the person that I care about most from suffering because of MY own flaws, that means my life was a complete failure. I told my therapist all of this, and yet she just couldn’t trust me at all. And if my therapist can’t trust me, how am I supposed to reciprocate?
The thing is, that wasn’t even the only way my therapist damaged my trust as my relationship with her deteriorated, it was just the straw that broke the camel’s back. I also can’t even say that I really blame her. Suicidal patients cannot be easy to deal with especially with the limited resources these practitioners are given, so really it’s probably just my fault for being born so mentally fragile (maybe I’m unfixable) as well as the medical system’s fault for being so rigid and inflexible in how it handles mentally ill patients. Nonetheless, I would have much much rather that they just fired me as a patient instead of call the police on my residence, and I’m just shocked that they legitimately thought this was the best way to help me.
**TLDR:** This was several months ago, and at the time, I thought this wouldn’t effect me that much. However, now I’m realizing that I’m actually really scared of going back to therapy. It felt dehumanizing to have my trust damaged like that, and having the authorities called on me by my own therapist made me feel like a lost cause. Even if I were to ever go back to therapy I’m not sure if I would ever feel comfortable disclosing my suicidal thoughts again. But at the same time, with absolutely no one to talk to, I can feel my suicidal ideation worsening and spiraling. The past year has ruthlessly beaten me down in many ways, but now I’m just at a loss. What do I do? If anyone could give their thoughts, I would appreciate it so much.
| 2 |
I no longer feel like doing anything on Lexapro/Rexulti. Any similar experiences? Should I be worried?
|
Hi there.
I'm 28M and I suffer from severe agitated depression as well as ADHD. I ran into this sub while googling Rexulti.
I've been cycling through different treatments for the last 10 years or so trying to find something that sticks.
My new doctor has been slowly shifting me away from Vyvanse 70mg and Venlafaxine to different drugs to see what works.
Right now I've been off both for two weeks and I'm on Lexapro (20 mg) and Rexulti (1mg) with Bupropion XL 300mg to help with the side effects of not taking Vyvanse anymore. (After my electro-encephalogram results came in we were both scared at how blackish-red it looked and how agitated my frontal lobe and central parts of my brain were so he was thinking we could shift to drugs that weren't stimulants).
Problem is: I don't feel like doing absolutely anything. I no longer want to play video-games, I don't want to work, I don't want to have sex, I just want to lay in bed as I think about either dying or sleeping and this feels absolutely horrible.
I don't know if I should just be patient or if this is something that people feel with Rexulti/Lexapro. Has anyone had a similar experience?
| 2 |
Severe psychiatric disorders greatly improved by treating lupus
|
>Markx and his colleagues discovered that although April's illness was clinically indistinguishable from schizophrenia, she also had lupus, an underlying and treatable autoimmune condition that was attacking her brain.
>After months of targeted treatments - and more than two decades trapped in her mind - April woke up.
>The first conclusive evidence was in her bloodwork: It showed that her immune system was producing copious amounts and types of antibodies that were attacking her body. Brain scans showed evidence that these antibodies were damaging her brain's temporal lobes, brain areas that are implicated in schizophrenia and psychosis.
>The team hypothesized that these antibodies may have altered the receptors that bind glutamate, an important neurotransmitter, disrupting how neurons can send signals to one another.
>Emerging research has implicated inflammation and immunological dysfunction as potential players in a variety of neuropsychiatric conditions, including schizophrenia, depression and autism.
>In one study, published last year in Molecular Psychiatry, Tebartz van Elst and his colleagues identified 91 psychiatric patients with suspected autoimmune diseases, and reported that immunotherapies benefited the majority of them.
https://news.yahoo.com/catatonic-woman-awakened-20-years-170930389.html
| 28 |
I’m on 300 MG of Wellbrutrin and 30 MG Adderall. Doc wants me to try abilify or reluxti. I’m worried about trying an antipyschotic drug. Is abilify or reluxti typically tried before remeron or tradazone?
|
Just want to hear everyone’s experience. I struggle with intrusive thoughts, anxiety, major depression disorder, and ADD. I have low energy.
| 7 |
Higher immune-related gene expression in major depression is independent of CRP levels: results from the BIODEP study
| null | 2 |
Lexapro detox
|
I’ve been on an ssri for 5 years. My depression is currently bad so my doctor wanted to try an MAOI. I had to stop lexapro for 2 weeks, I’m in week 2 of very low dose Selegiline and feel awful. Could this be due to the lexapro detox? Anyone done this before?
| 2 |
The long term effects of taking antidepressants on our physical body, possibility of getting off of the medications.
|
This question is for people who have long time depression and anxiety, have been through a high doses of meds that has actually improved their conditions and after successfully completing the courses have eventually stopped taking them with doctors recommendation and haven't relapsed later.
I don't know whether even there are cases such. But after over a decade of battling with severe depression and generalised anxiety, when I finally started my treatment I had a clear goal. I want to treat my conditions like any other health condition and take the help of professional to make it go away or atleast be manageable. I don't want to curl up on a bed for rest of my life sinking in the darkness of my mind. Now after a sustained period of my body adjusting with a meds, showing improvement and carrying a bag filled with meds, and feeling free of the dark thoughts and crippling anxiety for smallest of task, I wonder when I will be in the other side of it. When I don't have to rely on the meds to function.
I understand many of the drugs and their efficacy are still not fully understood. What could be the long term effects and whether in order to fix one thing I am breaking something else. Whether my heart or my liver or my kidney is going to bail out.
I have expressed this concerned to my doctors. Have also specified them I do not wish to maintain the laundry list of meds indefinitely. They have assured me gradually it will be tappered and I may have to be on one or two meds in future. One of them have explained me this like taking an insulin for diabetes or taking medication for blood pressure or thyroid. And I do have understand his theory. But I would like to know from people who have been in my place, what waits for me in the other end, after I finish the course the treatment or will it work or not.
| 14 |
Bupropion midsection weight gain
|
I was on 150 XL for about 3-4 years (stopped on two occasions when pregnant and nursing). After a rough year, I went up to 300 XL. This was around November. Not sure I felt much a difference mood wise or energy wise but I swear I’ve gained weight mainly in my belly. I feel so bloated all the time. My diet and activity level hasn’t changed. In fact, I barely eat during the day and I’m constantly on my feet caring for my two young children.
I don’t know if I should go back down to 150 XL or maybe try SR? All I know is I hate feeling this way and looking so bloated. When I first started on Wellbutrin, I felt great- energized and even lost a few pounds. I’m scared to stop because I do think it helps a little but I don’t like the way I look. Has anyone else experienced weight gain? Thoughts on switching to SR? Any advice is appreciated.
Edit: bowel movements are normal. No GI issues,
No constipation (I know that is a possible side effect). This is more fat/water issue.
| 3 |
Abilify & mania
|
has this drug caused mania in others? as soon as i took this drug i just wanted to drink, drink, drink, have sex and smoke
| 2 |
Added Wellbutrin 150mg to my treatment
|
Hello everyone,
I've been on 150mg Venlafaxine for a while now, around 3 years, and 4 days ago I've started taking Wellbutrin 150mg. I'm writing this more to have a journal on how my treatment is progressing.
I've felt pretty rough since I started taking it. Brain fog, headaches, zero appetite and my anxiety has spiked. Today I feel slightly better, less brain fog but still very "scattered mind", I can't seem to be able to focus on only one thing, I start doing things and never finish them, that kind of stuff.
I'm taking wellbutrin in the morning, same with venlafaxine, and while I am a bit sleepy and tired, I haven't had any naps or anything like that.
I also ordered some Magnesium Bisglycinate, hopefully will help me with my clenched jaw that I'm feeling since I started taking wellbutrin.
| 1 |
What’s the point of living if I can’t feel any pleasure and am totally numb 24/7?
|
Numb emotions, lost libido, zero pleasure in orgasms. Just all around numb. Why should I live?
| 3 |
Pregabalin + Olanzapine + Fluoxetine ??
|
I just left my psychiatrist's office (the first time visiting her) and was prescribed these 3 meds to treat depression and anxiety. I haven't taken any of them yet and was wondering what to expect from this combination. I will be on 75mg of Pregabalin, 20mg of Fluoxetine and 2.5 mg of Olanzapine a day. If you are on this combination of meds or know about it your experiences would be appreciated.
\- Also if there are more appropriate subreddits for me to post about this in, please let me know.
| 3 |
LDN?
|
Feels more or less scammy? A new doctor perscribed it to my mom, and she said I should try it as it helps autism (which i was under the assumption that nothing can) and depression. She has a bunch of books (not medical) on how amazing it is, that it has no side effect, non addictive and can cure just about anything under the sun like cancer, psychosis, ms, etc. Its very wild, and I really dont trust it, but I have no reason to yet. Has anyone heard about it?
| 4 |
i think i’m ready to give up completely
|
i’ve tried lexapro, zoloft, viibryd, trintellix, cymbalta, wellbutrin, auvelity, adderal, ritalin, concerta, and gabapentin and gotten nowhere but worse.
all of the ssris + the wellbutrin and auvelity have made me a lot more suicidal than i already am and give me side effects that make it impossible to even function. i’m already overweight so anything with weight gain associated it with it is already a no go for me as well as antipsychotics are something i’m not interested in trying as a mono therapy (my psych has pushed this since we started) as they can cause weight gain and increase blood sugar as well as risk some other terrible side effects that are sometimes irreversible. i’m just ready to give up
| 14 |
Depression (Rant)
| null | 1 |
Seroquel for anxiety
|
I was prescribed 12.5 mg twice daily for anxiety.
I did not take it as being an anti psichotic but my anxiety is out of control.
Has to build up on the system?
Any experience on it?
| 1 |
Substitute for Rexulti
|
I can’t afford Rexulti even with insurance and coupons. I’ve been on 2mg for a while and I haven’t taken it in a week and I feel really depressed. Not schizophrenic or bipolar.
I tried abilify a few years ago but my doctor said I didn’t need it and I stopped with no side-effects/downsides. Should I ask to try it again or is there another option? I’m scared to start another medication
| 4 |
Lyrica 150mg (50mg 3x daily)
|
Hello,
I am a 23yo male with Bipolar II and am on Lithium. Sadly I am resistant to any type of serotonin drug (SSRI’s, SRNI’s, Buspar, etc) as these cause me to slip into mania. I have a very trusted and great psychiatrist so I do not need advice on whether my treatment is correct or not but opinions on how you’ve handled Lyrica for anxiety and what side effects and positives you’ve had on it & etc. I was prescribed 50mg 3x daily since I have awful GAD but can’t take the “normal” meds for it. I have Ativan for PRN but don’t take it daily due to not wanting to be dependent on it. Thank you!
| 3 |
Does abilify for depression cause hallucinations?
|
I’m on 2.5mg abilify for 3 months and 10mg lexapro for 8 months for depression and recently I’ve started to hallucinate people calling me, screams, flashes in my periphery, bugs on my skin when looking away, people in the background.
I usually experience them once or twice a day. Does anybody else have this problem with abilify?
I’ve seen posts about abilify causing hallucinations but it’s on r/antipsychiatry so I’m not really sure if I should listen to them lol
| 7 |
Selegiline
|
My doctor prescribed my severely depressed son Selegiline tabs. We are working towards a dose of 10mg/ day, at 5 mg he still has no response. Is this to be expected. I’m worried about first pass metabolism and bioavailability. His neuropsychiatrist says there was no need to get the very expensive Selegiline patches but now I’m worried. Has anyone else taken regular tabs before,not sublingual.
| 8 |
What should I try next?
|
I started taking medication for depression and adhd in september; started with adderall 10mg twice a day, then added wellbutrin 150 and upped adderall to 20mg twice a day. After a couple of months my psych upped the wellbutrin to 300mg, and then 2 months ago to 450, along with starting intuniv 1mg twice a day( i was also on lexapro for a few months but stopped because of complete emotional numbness).
So far, i think the Wellbutrin has helped with my mood and the adderall has helped with my ability to focus at work, but otherwise I’m constantly exhausted, my motivation is still rock bottom, and i no longer engage in any activities i enjoy; everyday i just go to work and then go home and sit in front of the computer until i go to sleep. I WANT to do things i enjoy, like going to concerts and playing video games, but when it comes time to do it, i just… can’t.
I strongly suspect this in particular is because of the Wellbutrin, but I’m not sure what alternative medication to try. I figured i would ask here first since my psych tries to argue with me about everything. Any suggestions? Thanks
| 2 |
The intersection of astrocytes and the endocannabinoid system in the lateral habenula: on the fast-track to novel rapid-acting antidepressants - Molecular Psychiatry - 2022
| null | 18 |
Why sleep deprivation helps??
|
I’ve been in a terrible state for just over 2 years. My trauma/PTSD was triggered by some ongoing difficulties my pre-teen daughter is having. I have been on Lexapro (ecitalopram) for 8 years but suddenly stopped working about 2 years ago. Was prescribed Venlafaxine/Mirtazapine combo which almost made me worse. Managed to quit Venlafaxine by cross-tapering to Paroxetine (6 weeks of pure Hell) and slowly tapering off Mirtazapine, after trying to stop it 3 times unsuccessfully.
It’s been so, so hard as nothing seems to work and it’s frankly a miracle I’m still hanging on. It’s only because of the effect I know it would have on my children if I wasn’t here.
But one thing I’ve discovered makes a difference is missing a night of sleep. I discovered this by chance as one of the side-effects of coming off Mirtazapine is insomnia. Curiously, the next day I’m sort of back to my old self, not bouncing with joy, but ok but it only lasts until I sleep again. I’m endlessly stuck in a loop of waking with terrible panic, anxiety and SI, which lasts most of day till evening, when it abates a bit. The other thing I’ve found works is cold-water swimming which also seems to bring me back, if only for 1-2 hours.
Does anyone know why these two things bring temporary relief? Could I have a cortisol/adrenaline/adrenal imbalance that’s somehow reset by lack of sleep/cold-water exposure?
Many thanks for reading 🙏
| 13 |
What would help me with my current struggle?
|
I take 20mg Prozac for depression and 7.5 olanzapine as a antipsychotic as well as propranolol for anxiety as needed. The anxiety is still there and hits me as soon as I wake up, sometimes lasting all day. I worry about everything and put off stuff because of it. It’s hard to feel and stay reassured and relaxed. I depersonalize sometimes and get brain fog. I find it hard to get motivated too and constantly worry and can have trouble connecting with others because of it. I’d say my most calm moments are probably at night when the day is over.
| 3 |
More promising results for Ansofaxine (first true SNDRI)
|
Can't get FDA-approved fast enough.
| 17 |
Is This Anhedonia?
|
Hello, I'm currently taking Anafranil 75mg for my OCD, and it's working even better than I expected. Although the recommended minimum dose for OCD is 100mg, I'm finding that 75mg is already helping me by about 90%. However, I've noticed that I don't feel a sense of urgency anymore. I constantly procrastinate and tend to put off tasks until tomorrow. This is causing me to worry about potentially being fired from my job because I always feel behind others and struggle to complete tasks. Additionally, I feel like I've become less intelligent compared to before. I have difficulty concentrating and lack motivation when reading, and even watching videos becomes challenging unless they get straight to the point. I may be panicking, but I can't shake these concerns, even though I've seen worse experiences on this subreddit.
| 3 |
stimulants for depression or trauma?
|
it’s alleviated somewhat over the years but i’d still put my depression at moderate. what’s worse is after the lack of motivation triggered by depression my working memory and task initiation is shot. it’s like my mood has caught up some days, but not the rest of my body.
finally treating sleep apnea has helped positive reframing actually work and my brain doesn’t feel like it’s full of garbage and fog. it takes a good few months for the treatment to take effect.
i was considering trying to do things to increase baseline dopamine because i’m worried meds will decrease my ability to function on my own over time. this would be exercise, yoga nidra, sunlight, nutrition, and true rest. i have not taken care of these things in over a decade.
but i’m too depressed a decent amount of the time to do it. when i’m not depressed, i still don’t have any habits in place to have a productive day. my body is always in a freeze state and i’m constantly getting retriggered.
| 4 |
I really need help and my latest provider isn't helping
|
I am in desperate need of assistance in determining which medications to consider next. My healthcare provider appears uncertain about the appropriate course of action for my situation. Despite my month-long tapering off of Viibryd, my depression has been deteriorating. As a result, she casually suggests that I return to taking Viibryd. This does not inspire confidence in her ability to develop a comprehensive plan; it feels more like a random attempt without careful consideration. How can I locate a doctor who possesses intelligence and expertise, rather than one who simply prescribes medications haphazardly?
| 3 |
Overview of new protocol for TMS called SAINT and how it treats depression
|
[https://www.sciencealert.com/we-may-finally-know-why-magnetic-stimulation-on-the-brain-can-ease-depression](https://www.sciencealert.com/we-may-finally-know-why-magnetic-stimulation-on-the-brain-can-ease-depression)
| 20 |
Baclofen has a rating of 8.8/10 for alcohol withdrawal
|
Many users there report that their lifelong anxiety and depression that made them drink alcohol vanished with high dose Baclofen.
I have as well used Baclofen and found tremendous success for anxiety and depression.
Why is it not more popular ? Does someone here use Baclofen to treat their depression ?
Because the interesting thing here is that Baclofen doesn’t only treat actual symptoms of alcohol withdrawal, it treat the underlying depression & anxiety of alcoholic and I think it’s beautiful and should be investigated for non alcohol mental health problems.
| 11 |
Is weed effective for TRD (& extreme fatigue ) ?
| null | 5 |
Backward signals in depressed brains
|
While this, no doubt, isn't the end of the story, it's a piece of the depression puzzle.
| 7 |
Anyone tried -accelerated TMS -(itbs) ?? Is it effective? Studies says 90-100% success rate 😕
|
& How much its price ?
| 2 |
Been on vilazodone for four weeks, depression has essentially been healed
|
Just this morning I am entertaining business ideas while still being grounded. A couple of months ago I remember I felt so energy less, such a lack of enthusiasm I felt. I am 29. I couldn't imagine how the people who ran business in their 40s and plus managed to do so. where did they find their passion from? This memory made me realize that I am actually out of depression.
I feel healthy and happy.
The essential medicines are 300 MG bupropion along with 20 mg vilazodone.
| 20 |
Has Anyone Tried Moclobemide?
|
Hi there,
When it comes to MAO-I I see a lot of positive reviews about Nardil and Parnate for depression and anxiety but hardly anything about Moclobemide. Has anyone tried it ? What was your experience with it regarding depression or anxiety?
Thanks in advance
| 3 |
How big is the jump from olanzapine and martizapine?
|
I cant see a psychiatrist for a couple months so Im uselessly looking at other options. Right now Im on martizapine, mainly for gastroparesis, but it also helped me a lot with my motivation and sleep. I dont want to give that up but it also made my anxiety way worse.
I saw that olanzapine is prescribed for the disorders im suffering with, and would still help with gastroparesis and insomnia. Would a smooth switch be possible? What are the main differences?
| 3 |
For those that take Prozac and propranolol what other medicines do you take with them that help with anxiety and depression
| null | 1 |
I've Stopped Viibryd
|
I have been gradually reducing my intake of Viibryd, but unfortunately, I am experiencing an exacerbation of my depression symptoms. It appears to be directly linked to the process of discontinuing Viibryd, wouldn't you agree? Since I have been depressed for the past three years, I didn't feel any noticeable benefits from taking Viibryd, which is why I decided to stop using it. However, I am currently still taking Wellbutrin.
I recently started seeing a new psychiatrist, but the initial prescriptions she provided haven't worked out well for me. She prescribed Luvox and modafinil, but I experienced significant feelings of derealization, prompting her to advise me to discontinue all medications. I'm hesitant about stopping Wellbutrin, though, and I need to clarify this matter with her.
Overall, I find it frustrating that doctors often lack a comprehensive understanding of my situation and resort to making educated guesses, which frequently lead to ineffective outcomes or intolerable side effects.
My primary concern at the moment is whether the increased depression I'm experiencing is a result of tapering off Viibryd or if it could be attributed to the side effects of the medications prescribed to me over the past three days. I'm feeling extremely down and overwhelmed, as these medications have failed to alleviate my depression, while the accompanying side effects have been extremely challenging to cope with. I'm at a loss regarding what steps to take next and I don't feel confident in my new doctor's ability to provide suitable guidance. Unfortunately, none of the healthcare professionals I've encountered thus far have been able to provide me with the help I need.
| 2 |
Discord Server for Depressed People
|
[https://discord.gg/YpKapZWbPr](https://discord.gg/YpKapZWbPr)
Share your experiences with people who would understand
| 2 |
Lipid peroxidation biomarkers in adolescents with or at high-risk for bipolar disorder
| null | 5 |
For those whose mood improved as the day went on what do you do/take now that makes it easier to get up and have a positive drive/outlook in the morning
|
My mornings are a struggle lately
| 3 |
What are your thoughts on Trintellix vs Viibryd
|
Background is the usual tried everything, nothing works, have tried over 20 meds, SSRIs, SNRIs, every Atypical, Mood Stabilizers, Anticonvulsants, yada yada.
Had a psychiatrist visit yesterday and I showed up like "Yeah, I'm just stumped, I'm maxed out on everything and don't feel any better" and she has been bringing up a cross taper to Trintellix a lot. She mentioned that Trintellix isn't in the formulary and I would have to get special approval, but didn't say what that entailed other than a nurse would have to call me back a few days later. I didn't like the idea of fucking around with non formulaic stuff because I'm not exactly rolling in cash. I remembered that she usually follows up mentions of Trintellix with Viibryd, which has a generic by now and is formulaic, so I asked for that instead. And she was cool with either so we opted for the Viibryd.
And I'm just wondering if I should have opted for Trintellix instead. I mean I guess nobody can say for sure, since I'm so far gone now that psychiatry in my case is just going "Fuck it, let's try it and see if it works". I didn't do the research beforehand but it seems like Trintellix works on a lot more stuff than Viibryd.
Current meds if it matters are
Wellbutrin 450mg (Trintellix has an interaction with this but Viibryd does not)
Remeron 30mg (cross tapering with viibryd)
Viibryd 10mg
Propranolol 20mg (for essential tremors)
Seroquel 100mg (I don't sleep without Seroquel, I don't have a sleep reflex naturally, have already tried every Z drug, Restoril, Hydroxyzine, and Trazodone)
What do y'all think?
| 2 |
How different is Trintellix from the classic SSRIs?
|
I know that Trintellix is sort of in a class of its own as a medication due to its agonism of seretonin receptors in addition to SERT inhibition.
But how much does that really translate clinically in terms of it being different (according to their claims "better") versus the conventional SSRIs.
There seems to be a lot of skepticism on the part of providers about this medication (which I take) so I'd be interested to know if anybody has heard some candid opinions about it from informed sources.
| 6 |
Serotonin production: Taking meds and improving your gut health.
|
This is something I've tried researching into, but I can't find much on it.
If you were to improve your gut microbiome, would this affect how the meds operate?
Given that 70% of Serotonin is created in the gut, and if you happen to eat a poor diet, you're not getting nearly close to that 70% because it hinges on your gut microbiome being in great working condition.
So, if you were to really improve your diet and focus on your gut microbiome, I wonder how that would affect the meds ability to process serotonin, if at all. I've been trying to improve my gut health recently ( I eat fairly well ), but I'm trying to do a restart on my system.
The last few days I've been feeling extra awful, and I wonder if the improvements I'm making with my diet, is having some knock-on effect to my Zoloft.
Curious..
| 5 |
Still don’t want to get up in the morning
|
What it says in the title. I had a massive nervous breakdown 20 months ago, then a nightmare year of disastrous medication tinkering by a psychiatrist who didn’t know what the f she was doing. I’ve been back on Prozac, which she really should never have taken me off of, for the last six months, and have been tapering down/off of lamotrigine for four months and feel much more like myself. I slipped a disc six months ago as well but that’s healing and I can do a lot of the physical things I haven’t been able to do since November. And it’s springtime, the days are longer, it’s sunny, I’ve managed to complete deadlines that a few months ago I didn’t think I would be able to given the brain fog, my book won an award, last week I got a job offer, and I have another interview coming up (there are NO jobs in my industry atm so this is a pretty big deal). My husband is wonderful, the puppy we adopted four months ago is a dream. And yet I can’t drag myself out of bed because being awake just doesn’t feel worth it. My mood throughout the day improves and by evening I feel happy, but in the morning I genuinely don’t see the point of anything. I work from home so manage to scramble to do everything in the afternoon (I have adhd so hyperfocus helps!) What gives? Am I still depressed? Is it PTSD? Does anyone else have this and do you have solutions? (Obv not looking for professional help, just ideas!)
| 4 |
Overwhelming agitated depression spell help
|
I’m not sure what to do right now. I have agitated depression and I’ll go through random spells where I am an impossible human. I’ll start off by saying I do better when I’m by myself but I’m not alone tonight. Overwhelming sadness mixed with severe agitation. My husband has been out of town for work and he’s back this weekend and everything he does is pissing me off. From simply breathing to noises when he’s eating. My cats keep licking themselves and it’s sending me over the edge. I’m trying so fucking hard not to snap because I am completely aware no one deserves this from me. But yet I feel so out of control of my emotions. My husband asks what he can do and I don’t have any answers. He is so worried. I feel terrible about it. I’m bawling in the living room by myself out of complete frustration. I am so so frustrated with myself, I want to badly to be normal. To be able to enjoy time with my husband and snuggle with my animals but I am so fucking on edge. I can’t sit still, I feel like I can’t breathe, nothing it calming me down. What helps you guys? I need something quick. I thought about taking a sleeping pill and trying to just sleep it out. I also thought about going for a drive but I don’t want to freak my husband out with worry. I feel fucking insufferable and I’m so down right now. Anything helps.
| 8 |
For those with anxiety and depression with motivation issues what medicine do/can you take at night that helps you wake up more willing to take on your day in the morning?
| null | 13 |
Tried every antidepressant under the sun and feel like garbage
|
I’m a recovering alcoholic and have been sober now for 2 months. (Not by choice, but because I have been forced into it, and I don’t want to be homeless.)
I am miserable without my daily numbing with alcohol.
I have had 2 suicide attempts this year, all fueled by blacked out boozy benders.
Being in 2 psych hospitals has traumatized the absolute shit out of me, and I am still recovering over that. The first facility did nothing but increase my buspar(which never did anything for me), and the second place which was even scarier just had me start Abilify in addition to my SNRI.
I did an outpatient program afterwards, and then got my meds changed once again.
I’ve been on every SSRI, Buspar, Cymbalta, Abilify, Gabapentin, you name it.
The restlessness and ravenous hunger from abilify was so bad that I got switched to Vraylar.
Vraylar was okay, but when it was increased to 5MG, it made me super restless again.
They bumped up my Pristiq to 100mg, decreased my Vraylar back to 1.5MG, and increased the Gabapentin and I feel fucking terrible.
I cry everyday and just want to drink in peace.
All of my privacy has been stripped from me so that I cannot buy alcohol, and I am treated like a child at my ripe old age of 35 years. I am so miserable and tired of every day feeling like the movie Groundhog Day. Work, eat, watch tv, sleep, repeat X5.
What other psych meds could even help me at this point?
I am willing to do anything and just want relief.
Sometimes I think I just might end up out on the streets because alcohol is the only thing that brings me happiness and takes away my problems.
Sorry for the long rant, I am just at a loss for words these days and have been through a lot of trauma.
Any advice or support would be greatly appreciated.
| 30 |
What does it mean about my brain chemistry that I feel derealization on Modafinl
|
I'm only on day 3 of Modafinil. Took 100mg the first 2 days and this morning took 50mg. I don't feel energized or motivated at all. I feel spacy, not present and have derealization.
Since this medication is supposed to be quick acting, what does this say about my brain chemistry that I have having this reaction to it?
| 3 |
Anybody else who feels Abilify is the gift and the curse?
|
I've recently begun taking Abilify and it feels god send, I feel a lot less depressed and a lot more stable. At the same time I feel kind of too energetic. Like I can't sit still and talk all the time, I can't sit still in school and just liste. Anybody else who've tried this side-effect?
| 2 |
I have a flue. Suicidal feelings flaring
|
I absolutely don't want to do life like this, I have been booked off from work. I am working from home and I don't feel physically wonderful but I'm managing. I'm starting to wonder if being sick is causing me to be terrified because a "caregiving" and people pleasing parentified child it was not allowed. Mother had to always be more sick. I also felt to vulnerable especially sleeping in front of her, and felt concerned about whatever medication she gave me.
Im sitting here in panic because I don't know if my bosses are angry with me, I know since the pandemic one can't come to work with anything like symptoms.
Some of my work mails are bounced back and I just become extremely stressed into panic( regardless of my medication) I just feel like I am not coping and I'm angry and tired.
Too scared to bring it up with Dr. So tired like I don't want to try anymore. I have exams and I am not able to focus. I feel like I'm in danger.
| 2 |
Has Anyone Just Stopped Trying Meds If None Work?
|
Meds have never even remotely helped me and I'm at the point where I'm considering just stopping them and stopping trying to find meds that help. The period where you're trying new meds and experiencing side effects and not feeling better is just awful and so discouraging. I'd wean off--not stop cold turkey. Anyway has anyone else gotten off their meds and been okay?
| 11 |
What makes you gain more weight — remeron or olanzapine ?
| null | 1 |
Which psychotropic medications and medication combos worked best for you?
|
For which condition(s) did you take them? How good did they work? Did they abolish all or most of your symptoms? Did you experience any major side effects? At what dosages did you take those good meds?
| 6 |
Ketamine Matches 'Gold Standard' in Major Depression Trial
|
This is reassuring to read if you're trying ketamine.
| 2 |
can lack of appetite from a med can be making things worse in the long run?
|
i just cannot get myself to eat anymore thanks to wellbutrin (and trauma related to food but that's another story)
if i don't forget to eat, i cannot stomach eating anything, esp if it is whole foods bc they take so long to eat and feel like such high quantities, and i don't even eat highly stimulating foods like fast food ever where i have much to compare it to.
i'm too exhausted to do anything and although it's curbed binge eating for me, i wonder if just not eating properly is making it hard for me to get out of bed, have energy for my day to day tasks, etc. it takes me all day to get hungry and after i did just now finally, i had fruit without a second thought.
i had been considering adding a stimulant but now i'm wondering if half my problem these days is just not eating.
| 1 |
Starting clonidine…will this worsen my depression?
|
Hey everyone! So I have severe depression, generalized anxiety, ADHD, and OCD. I’m currently on 120 mg of Cymbalta a day for depression, 20 mg Adderall XR, Clonazepam .25 mg as needed up to twice daily for anxiety, and I take propranolol 10 mg(?) to help with the “heart beating out of my chest” feeling that comes with Adderall for me. (I also take Claritin daily, don’t know if that matters but I’ll throw it in just in case).
I’m starting Clonidine because of the excessive sweating and overheating assumed to be caused by Cymbalta. Once I start Clonidine, I’m supposed to stop taking Propranolol and Clonazepam since Clonidine should help with both the crazy heart beat and the anxiety I feel from the Adderall.
I’m excited because Clonidine should help boost the positive effects of my Adderall while also minimizing the negative effects of Adderall. I’ve also seen that it can help with OCD which would be GREAT!! But at the same time, I’ve read that it can cause depression and I am worried about that.
Has anyone taken Clonidine and anti-depressants? Or has Clonidine made anyone’s existing depression worse? Or has Clonidine been great for you and not worsened your depression? I’m curious to hear about your experiences!
| 3 |
Modafinil for TRD
|
I've been wanting to try Modafinil for awhile hoping it would help with TRD. I started it yesterday and got a severe tension headache. And then today I just feel very off and tired. I was not expecting these results. I've reached out to my doc and waiting to hear back.
Has anyone experienced this? It's not a crash tired. I never felt energized at all. Just really shitty,
| 3 |
I feel LESS depressed when I’m on my period, WHY??
|
A lot of people speak of getting more depressed during menstruation, I occasionally do maybe a week before my period however most of the time when I’m on my period I feel less depressed. I still get negative emotions such as sadness or anxiety and cry, however I’m still FEELING emotions whereas I’d usually feel numb, and I also feel feelings of motivation and a sense of power like I wanna do 200 pushups/fight a bear and dance, food tastes better too and music sounds better and I want to do hobbies I usually put of like art and music. Why is this??? What hormonal fluctuation is the cause of it? I wish I knew a means of sustaining these feelings.
| 2 |
What’s the general consensus over what medication is effective against anxiety/depression/motivation issues
|
What have you noticed people said that helps them
| 3 |
Does anyone else “feel” their brain during a depressive episode? Is there a quick fix?
|
I had a bad depressive episode this past week, despite being relatively stable for about a year. My brain felt like I had been crying for hours and hours, but I haven’t been crying. My brain feels tight or swollen, I feel depressed and my body feels like a shell, or an empty vehicle. I hate this feeling and it took several days to go away like a brutal hangover. Actually, that’s the best way to describe the head feeling…like a very dull hangover. How do I get rid of this feeling quicker? It honestly only went away with time, but the wait is so frustrating.
| 2 |
How long does it take to know Abilify is working or not ?
|
I’m about a week in and feel bad .
Am I supposed to give it more weeks ?
| 2 |
What could be the reason different people have such different response to the same medicines?
|
One of the most interesting thing that I have observed is that, for some people, it is possible to take any antipsychotic along with any stimulant medicine, and they work just fine. While for others, the antipsychotics render the stimulants ineffective.
​
Why do people respond so differently to these medicines?
| 2 |
People who have suffered from depressive disorder and/or generalized anxiety for years, especially during their formative years--- after starting treatment and on medication that actually ease your symptoms, does it feels off?
|
I am suffering from deep depression and generalised anxiety for more than a decade. Only recently I seek out medical assistance. After over a year worth of trial and error, changing doctors, I finally got a combination of medication that is actually working. My doses are probably quite high and consist of quite a long list of different compositions. Apart from my sexual drive I actually doesn't have any more issues. I can function completely fine, take social and work projects easily, look after me and loved ones, do daily chores and work regularly. One can say I'm doing much better than people without my conditions. But there's a lot to improve which may not be exactly directly related to my conditions or symptoms but I am taking small steps everyday I believe.
Recently due to some family emergency, I had to endure a lot mentally and physically. And after it resolved, I am having a short of burn out. I talked to my doctor two days ago. Explained my conditions, he said everything is completely fine and it's okay to feel burn out when subjected to external stress. I agree with him objectively but back in my head I have this nagging fear of a relapse. It happened to me before, where after two months of recovery without any reason everything collapsed and I spiralled into the darkest phase of my depression.
But one thing I am having a difficult time to understand. During my last appointment, I explained to my doctor that how I feel like I am in autopilot and somewhere I am not able to feel things like I used to before. Like floating in a steady stream but not getting wet. When there's a deadline I can't feel the stress or anxiety I used to have earlier and I feel uncomfortable. My doctor said this is because now my emotions are in control and I have much more capacity to take any outside trigger. But still it makes me feel like something is off about me, or I'm more like a machine now who can't actually feel anything.
Does this is how people without depression or anxiety feels? Or my coping mechanism is so ingrained in my brain that now when I don't have anything to feel anxious about I can't exactly know how to process everything? Or is this side effects of the medications?
| 6 |
For those that get quiet when they are depressed what medication helps with that?
| null | 1 |
Has anybody here tried Auvelity?
|
If so, did it work for you? About how long did it take until you felt it started working? Any side effects?
| 12 |
therapy is really disappointing, what is it even supposed to do?
|
it's like, i keep trying to iterate how i could've been so much more successful in school and life overall subsequently had circumstances been different, and she keeps responding with, "some people have certain abilities and talents, and they are able to ace exams without studying." every session.
like that wasn't the point at all. i also don't believe that? anyone can do what they put their mind to especially with academics, if they can't they probably lack proper support.
and people who ace exams without studying always crash in college, so it has nothing to do with what i'm talking about.
do therapists even listen? i've been doing therapy for like 3-4 years now going through different ones.
it's really frustrating to also be told that i'm simply incapable, that i should just accept that, and that "not everyone will graduate with honors" when i had a 4.0 my first year of college, graduated high school with all possible honors, and then became depressed. i was supposed to graduate with honors, i *was* clearly so capable, that's kind of the whole point.
| 6 |
What gave you the motivation and confidence to leave your bed more and oversleep less?
|
What made you feel better?
| 15 |
Started New Meds - What to look out for?
|
I just started a new regimen for my treatment resistant depression. I have been on Viibryd and Wellbutrin 300 and have been tapering off the Viibryd for a few weeks. Today I started Luvox 50mg, Modafinil 100mg and Wellbutrin 150mg.
I'm especially cranky right now. Could this be a side effect already? Just want to know what I should be looking out for.
| 2 |
Need to LOWER libido... L
|
Hey all,
Long story short I have ADHD and take Adderall and I believe they are actually raising my libido. I also take pristiq and back when I started it was actually one of the reasons I chose it, aside for knowing that it's a drug type works good for me, was because it is not known to affect libido. But now I really want the reverse...
My girlfriend used to really enjoy sex. But now with some changes in situation it's not so much. Maybe once a week, sometimes less. And those don't seem to come easy. If I do put effort in and seem to charm her or whatever, honestly my head is working overtime thinking that she really doesn't even want to be doing this and I can't either perform or finish. This is even if I take medicine for that particular situation - The problem is not physical it is mental and me thinking she doesn't want to even be here which completely takes me out of the situation and ability to finish. At this point it's really starting to wreck my life and pumping up my depression and anxiety greatly. Even seems to make my ADHD meds work less.
So to my question, is there something I can take, maybe something I can replace the Pristiq with, that will just hose my libido and the desire for sex? I know this is the opposite of what most people want and are asking for, but at this point it's really the only answer I can see to give me some peace.
Thanks in advance for any help, suggestions, or advice.
| 4 |
Day 24 taking with sarcosine
|
I've been on sarcosine for 4 weeks, it would be an antihedonic, it slightly increases the perception of pleasure, it doesn't seem to affect negative thoughts or motivation.
When I have to drive to a new destination I've never been to -even just 50 km as in this case, where I went to an office for bureaucracy - I usually look at the whole journey on google maps first, then put the navigator on. I'm very insecure, I never go to a place I don't know without checking the map or navigator even though I've been driving for years. But yesterday I told myself that basically I could do it, I could simply follow the road signs. And so I did. I didn't take the fast route but it felt like the first time in years I wasn't afraid to drive in an environment I've never been in before. Usually I'm not scared only on the roads I know and I feel quite confident there. This time it seemed that I was on autopilot, and on the way back I also deliberately took a slightly more scenic route and entered a small village on a hill and stopped for a coffee at the bar. I don't know, it was as if for a while all anxieties were gone and I made choices based on the pleasure of the moment and not on anxieties.
| 10 |
Clomipramine - no dreams
|
I've taken it for 1 month and I can't remember having a single dream since then. What does this entail?
| 3 |
Academic Research on Depression (18+, international, past exp with depression)
|
Hi everyone,
This may not apply to many folks on here, but I figured I'd give it a shot anyway. I am currently looking to recruit participants to complete my online research study that is part of my dissertation in clinical psychology. My research focuses on understanding the concept of Fear of Depression Recurrence, which captures fears that people who are remitted from depression may have about becoming depressed again. The goal of this online study is to gain a better understanding of the construct and validate the psychometric properties of a Fear of Depression Recurrence questionnaire. We hope that learning more about fear of depression recurrence may present a small window into understanding depression relapse and thus lead to better informed prevention efforts.
**Interested? Here is some more information about the study:**
***Were you ever diagnosed with depression? Do you feel better now?***
The ***Stress and Developmental Psychopathology Laboratory*** at Concordia University is currently recruiting English-speaking participants for a study investigating the potential fears that people who are no longer depressed may have about their depression returning. This study has received ethics approval and involves completing online questionnaires that assess the fears you may have about your depression returning, as well as the severity, frequency, content, and triggers of these fears. It will also ask you for basic personal information (e.g., age, gender, race/ethnicity, occupation) and questions about your current depressive symptoms, other mental health concerns, beliefs about depression, coping strategies, and quality of life.
The online survey will take approximately **1 hour** to complete. All components of this study can be completed remotely, in the comfort of your own home.
Participants who are eligible and complete our online survey will be entered in a draw to win one of **seven** $100 CAD Amazon Gift cards.
**If you are interested and you:**
✔ Are above the age of 18
✔ Have previously experienced an episode of depression
✔ Have no significant symptoms of depression during the last 2 months
Please click on the following link which will bring you to our pre-screening questionnaire to determine your eligibility. If eligible, you will be able to access our consent form and the online survey from this same link.
**Survey Link:** [https://concordiaccrh.qualtrics.com/jfe/form/SV\_8v5TiIGO7rSk5kG](https://concordiaccrh.qualtrics.com/jfe/form/SV_8v5TiIGO7rSk5kG)
| 2 |
Meds Combo
|
Is it normal to be on a low dose of Doxepin(25 mg) with Wellbutrin 150 Xl
100 mg Lamictal twice a day, Klonopin 2 mg and 5 mg Olanzapine
Depression and anxiety here…
Doctor just added Wellbutrin two days ago, my main issue is that I am afraid I’ll get anxious and it will counteract the effects of Doxepin and Klonopin…
Is anyone on a similar regimen?
| 5 |
Art saved me when I had nothing else. (Read comment)
| null | 50 |
others taking abilify twice daily?
|
i was wondering when my doctor put me on abilify at a really low dose to take twice a day has anyone else had similar experiences or should i consult my doctor again?
| 2 |
Tried several SSRI/SNRIs with little positive outcome. Questions about venlafaxine and ritalin, or just ideas?
|
Diagnosed with ASD, ADHD (which a psychiatrist later said was uncertain), GAD, social anxiety, MDD, and some psychs have suggested BPD or AvPD.
Been unhappy my whole life basically but the last year it has gone worse. A new symptom the last year is anhedonia especially anticipatory anhedonia. Currently I’d say that anhedonia and GAD are my main problems.
I’ve been on 4 SSRIs, duloxetine, and some other ineffective ADs, in addition to trials with ADHD meds. After a long break from SSRIs, my GP started me on 37.5 mg venlafaxine 4 weeks ago. It’s not going well. I’m very sensitive to many psych meds. On venlafaxine, I have a constant jittery and uneasy (“electrical” ish) feeling in my body, my thoughts are more scattered (which was already a problem), I wake up with my heart racing in the morning, and difficulty with orgasm. I know four weeks is early. But I was already hesitant to try yet another SSRI/SNRI after many failed trials, and I think there’s a considerable nocebo effect at play. I hate myself for accepting another med in more or less the same class, and I’m demoralized.
The only thing that can ease my anxiety is 5mg ritalin (and benzos but can’t get them). The effect varies a lot however. Sometimes it can change my whole outlook on my life, so that everything seems uncomplicated and straightforward. Sometimes it doesn’t work that well, but it always quits my mind to some degree. But I doubt my GP will refill the script given my ADHD diagnosis has been cast into doubt by one psych.
Has anyone had the same jittery experience with venlafaxine? Or the same effect of ritalin?
I’m ready to give up the venlafaxine. I just can’t do another six months with dose adjustments only to give up which is what happened with the other SSRI/SNRIs (except escitalopram many years ago but it pooped out eventually).
I’m considering asking for pregabalin, I’m at a point where I at least need to get rid of my anxiety quickly. Would ideally like an MAOI given my positive response to ritalin (and the inferred positive effect of dopamine) but I’m pretty sure I’d never get it.
I feel very hopeless and demoralized. Any input is appreciated although this may be more of a vent.
| 3 |
Question to people that have been suffering from depression since childhood: what helped you?
|
I feel like it's a very different experience to be suffering from depression since your childhood and suffering from depression when you are already an adult.
Most of the times when I read about depression, there's this assumption that I'm just in a depressive episode and things will go back to normal but that's not the case for me. I don't really remember what's normal. I don't really know how it is to feel "okay". I've always been depressed.
I've been having suicidal thoughts since my childhood. I've been obsessively thinking about death, illness, loss for all of those years. I don't really know how to wrap my head around all of this.
The therapists and psychologists I've been to, don't really know how to help me and psychiatrists just prescribe the most basic medicine and none of it works on me.
| 33 |
This is how I see it: we're all climbing a treacherous journey up a mountain. Cold, freezing, windy, dark, and dangerous. At any point, we can simply let go and drop down to a certain death... or we can press on until we finally reach the summit and finally get to enjoy some beauty of the world.
|
The black dog has bitten me real hard lately, despite my intense treatment regime. No doubt a consequence of tough living conditions lately.
I won't lie, I still get moments where I seriously plan an ultimate "Plan B" to exit life permanently.
But another part of me thinks: I've managed to fight my way this far... do I really want to destroy everything before I have a chance to enjoy some beauty of the world?
I've made it up the icy dangerous mountain this far. It's more treacherous than ever at this point, but I know if I keep going and use my initiative, the summit will very soon be within reach.
Ironic: no matter how high you climb, it's always so easy to plummet right to the bottom, but it's so hard to keep fighting to press on to finally reach the summit.
Here's praying we all make it there soon, and finally celebrate when we make it there, and enjoy the beauty of the world around us.
| 11 |
On a battery of meds, mood improved, drastically worse QoL
|
Howdy, I'm a 30yo male, long suffering with anxiety and depression.
Around 2y ago I restarted a regime I did in my late teens, mirtazapine/remeron 25mg. This was to address a poor self esteem, but I had a (barely) functional social life.
I was struggling with focus and concentration at work and caught wind of ADHD, learned a lot about it and went through an assessment battery. Started on Vyvanse which definitely helped with the these issues at work.
But I was still feeling pretty anxious and self critical, I was upped to 50mg mirtazapine.
Much the same, I asked the psychiatrist if I could try something different, he put me on 50mg pristiq/deslenafexine.
Since getting onto it, I've felt increasingly apathetic and lazy. I've progressively spent more and more time in bed each day, I've stopped socialising all together, I avoid calls from friends, I just don't have the energy to care. I don't hit low lows, I just don't give a shit about anything.
Each time I've seen him he's upped my dose of pristiq. He thinks it's the mirtazapine, or symptomatic of depression itself. I'm now on 150mg pristiq, going to 200mg. I kinda feel like I'm beating my head against a wall here. I don't know how more of the same is going to help, but hey he's the doctor. The mirtazapine definitely zonked me when I started, but at least I could keep up appearances. Since starting pristiq I'm literally doing nothing with myself.
Recap:
- 50mg mirtazapine
- 40mg vyvanse
- 200mg pristiq
Am I asking the right questions, am I right to question the approach?
| 5 |
A book that helped when I was depressed as f*ck
|
Hey all,
Most of you probably know the book but I want to share it because perhaps some of you might find this story relatable and maybe someone finds some hope in it.
It’s a bit heavy because it’s probably something that I’m still working through.
The video description on YouTube contains an affiliate link btw!
Let me know your thoughts and questions if you have any
[YouTube link](https://youtu.be/AGYdFNYCC5I)
| 0 |
Tetrahydrobiopterin for a case of very treatment-refractory depression
|
Hey guys,
I recently watched a remarkable video with the researcher Lisa A. Pan on refractory depression. [https://www.youtube.com/watch?v=XeJEoMNwlj0](https://www.youtube.com/watch?v=XeJEoMNwlj0)
In the video (7:56 min) Pan describes the case of a person with very treatment-refractory depression (no benefit from MAOI, stumulants, lithium etc.) and suicidal behavior who got treated with the enzyme cofactors tetrahydrobiopterin (trade name "Kuvan") and achieved remarkable improvements in depression and functioning. Pan stresses that the findings are preliminary. Just in case you are interested: The medication "Kuvan" is ridiculously expensive (US$100,000 per year). At least until the patent rights are valid.
You can find the case study refered in the video here:
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116226/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116226/)
I had never heard of tetrahydrobiopterin or about the metabolic conditions that it is supposed to treat. Exciting to see that extensive research has been done on the connection between depression and tetrahydrobiopterin for decades:
[https://www.sciencedirect.com/science/article/abs/pii/S0278584622001257?via%3Dihub](https://www.sciencedirect.com/science/article/abs/pii/S0278584622001257?via%3Dihub)
Besides tetrahydrobiopterin there exist also other related enzyme cofactors such as neopterin or biopterin? Any ideas how these could be utilzed as cheaper alternatives to "Kuvan"? What are your general thoughts on the topic?
| 8 |
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