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Any energising antidepressants that won't make anxiety worse or do they all increase anxiety
| null | 1 |
Help
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I’ve really been struggling with life lately. I barely have any energy sometimes. I always just feel less than everybody because I’m just a server at a restaurant and have no idea what I want to do and I turn 25 next month. I’m barely creeping along in community college too when I had a whole opportunity to go to university after high school but I was dealing with a lot of mental health stuff. I’ve also never lived away from home :( am I gonna be okay?
| 1 |
How do you Adult
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Night meds at 35 cant forget the iron and advil. My slow march to oblivion
| 40 |
good sleep aids that aren’t trazadone? also thoughts on pregaballin for anxiety?
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hi,
i currently deal with honestly a lot of different issues right now, trd, gad, social anxiety, insomnia, and some ocd like tendencies/traits. i’m currently waiting for the ketamine shortage to become manageable again so i can try that for my trd, but in the meantime i’m trying to find something to help combat my insomnia. i’ve tried melatonin and cbd and really they don’t help, i’ve found thc can be helpful but i don’t think that’s very sustainable as well as i would prefer to not rely on smoking something for sleep. i generally have issues with falling asleep bc my mind is always going 100 mph and i can never get it to just shut up and let me sleep. as well as i’ll wake up randomly.
im not interested in trying trazadone for sleep as it’s not recommended by national institutes of sleep to be used as a sleeping aid. as well as i don’t react well to ssris/snris and i know trazadone has a light ssri effect and i’d rather just not with any of those drugs after the experiences i’ve had.
i’m also looking into lyrica for anxiety, i used to use gabapentin but i felt like the effects diminished within a week or two of whatever dose i started and i had to keep going up. i’m moving back in with my bpd abusive mom in a week and my anxiety has been at an 12/10 basically and i was wondering if pregaballin might be something that’ll help me get though even just the first couple weeks or so.
| 3 |
Anybody take clonidine or guanfacine for social anxiety?
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So I have the symptoms of social anxiety such as extremely dreading things like interviews, going to the gym or store by myself, fight/flight symptoms like trembling, palpitations, stammering, rapid speech, mind going blank, etc.
​
I have done some research and am interested in trying one of these two medications: clonidine or guanfacine
​
They are both alpha-adrenergic agonists, a type of medicine that works to oppose the effects of the sympathetic nervous system (which causes the fight or flight symptoms I believe)
​
Here's clonidine's wiki page:
>Clonidine also has several off-label uses, and has been prescribed to treat psychiatric disorders including stress, sleep disorders,\[28\] hyperarousal caused by post-traumatic stress disorder, borderline personality disorder, and other anxiety disorders.
​
Here's guanfacine's wiki page:
>An off-label use of guanfacine is for the treatment of anxiety, such as generalized anxiety disorder and post-traumatic stress disorder symptoms. Guanfacine and other α2A agonists have anxiolytic-like action,\[15\] thereby reducing the emotional responses of the amygdala, and strengthening prefrontal cortical regulation of emotion, action and thought.\[16\] These actions arise from both inhibition of stress-induced catecholamine release, and from prominent, post-synaptic actions in the prefrontal cortex
***Anybody take clonidine or guanfacine for social anxiety? If so, please detail your experiences/dosages/etc. Thank you <3***
[View Poll](https://www.reddit.com/poll/14xzdi7)
| 2 |
anyone familiar w dr chris palmer's work? what do u think?
| null | 1 |
Three healthy and important herbs that help you maintain mental and psychological health, part 03.
| null | 1 |
SSRI&PSSD...first time on meds..I value my sex life
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So basically my life is chaotic, anxiety has been on high since I can remember, but as I've aged, it's gotten progressively worse. I think the worse, think of bad things, impending doom, dread, I have work anxiety, I hate my job and I literally lose my mind during my days off because I know the work week will be beginning soon..its affected my home life, my wife works in mental health and she's barely helping me, and my child is starting to see the affects. The only thing that scares me about ssri is the sexual dysfunction aspect, I don't want to risk damage to something I'm good at.
But ny depression and anxiety has gotten the worse its ever been, I just want to take back my life..not end it. What's the best approach I can take meds wise. I meet with my psychiatrist next week. Is there anything that can mitigate potential sexual loss..and still reap benefits from said medication? PLZ HELP ME. IM 34, MALE..
| 5 |
I feel like my Bupropion XL has stopped working what do I do?
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I have ADHD, PMDD, Major Depression, and anxiety. For the past 2 years I have been on 300mg of Bupropion XL. It worked great the first year, but not so great after the second. I had to move back into my parent’s house after graduating college which isn’t a good environment for me. I’ve had horrible art block for a year and haven’t been able to make anything or be creative. When I’m in my PMDD window, I take 200mg of progesterone because my meds completely stop working and I become a complete depressed mess for 10 days straight. Last PMDD cycle, the progesterone made things worse all of the sudden too. My bupropion helps me get out of bed and that’s it. It evens me out but doesn’t do great on the ADHD side of things.
When I can get my 20 mg adderal XL, things are better and I’m actually able to get things done, but of course I’ve been rationing it and I’m struggling. My head feels empty and I have zero motivation.
Should I switch to another medication? SSRIs made me a tired zombie and combining them with my Wellbutrin made me very itchy? I’m under 24 and I’ve seen some warnings for increased suicidal thoughts for people under 24 on some bupropion alternatives. Should I maybe just up my dose? My Dr. has suggested I try Trintellix or Strattera before, but I’m nervous to switch.
| 2 |
Please help me, I’m running out of options
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History:
Tried lexapro when I was 19 because i had anxiety, mild, was getting urinary retention on it so stopped taking it.
When I was 25 I was put on Effexor for a depressive episode caused by a breakup (couldn’t eat, didn’t want to live, etc). Worked well but lost efficacy so I switched to Wellbutrin after a few months.
While on Wellbutrin I was also given celexa and cymbalta at different times, both gave me urinary retention so I had to quit them. Also quit Wellbutrin because I was frustrated with the medical system at that time and Wellbutrin was making me quit smoking which made me irritable and angry and I didn’t realize it was not smoking and thought it was the medication.
At 27 I had a mental break after suffering a panic attack, developed agoraphobia, and have since been living with severe anxiety and severe depression.
Buspirone didn’t help. I took it for multiple months but the higher the dose the more suicidal I felt.
I was put on abilify, this gave me a manic episode where I felt great for a week and then hit very low lows where I was very suicidal.
Switched to mirtazapine, same thing happened.
Have been on Seroquel since, 150mg at night. Also take Ativan 2mg a day.
Tried adding Wellbutrin in but it gave me severe anxiety and urinary retention with the Seroquel so quit Wellbutrin.
Doctor had me add gabapentin, 300mg three times a day. Felt it wasn’t helping, was making things worse. Been off that for a couple weeks now.
I am at a very low point. I am frustrated with my anxiety being constantly high. I am very suicidal, but I don’t want to die I just want to get better. I can’t stop having these thoughts though.
I break down easily, will spend an hour crying for no reason. Even just writing this has sent me into a spiral.
I don’t know what to ask my psych for next. She seems frustrated as well. She wanted to put me on vraylar last time but I was worried I’d get urinary retention because of the combo with Seroquel and said let’s just wait a month and see how just Seroquel goes.
I don’t really want to increase my Seroquel because it makes me very tired and I’ve also gained a lot of weight and despite going to the gym everyday and (attempting to) diet, I can’t lose a pound. I come home and binge eat because I’m just so hungry.
I’m thinking of getting off the Seroquel and trying just an antidepressant like Zoloft or something hoping I don’t get urinary retention (this is why we have been trying antipsychotics instead of SSRI’s because I thought they gave me urinary retention but after Wellbutrin and Seroquel combo I realize it might just be the combo of multiple medications causing it).
I also just heard about anafranil and am considering that.
I’ve only been diagnosed with panic disorder, GAD, PTSD, and depression.
I just want to get better, I have been living terribly since my panic attack and it’s getting really hard to see the light at the end of the tunnel when everything just leads to a dead end.
My psych seems frustrated every time I see her, I only get 15 minutes so I need to make the most of it by being prepared when I go. Please help me.
| 5 |
What finally worked for your TRD?
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I've tried many different SSRI's/SNRI's with no luck over the past 2 years + Lamictal and Wellbutrin. I'm currently on Abilify and Concerta.
My doctor thought that upping the Concerta might help, but all it's done is completely delete my appetite. Abilify is the only thing that actually helps somewhat. It makes me very spacey at 4mg and up though.
Should I ask about an MAOI? I know Lithium was mentioned to me before, is that a drastic step?
I feel so bad for my doctor when nothing seems to be working... maybe I'll just always be this way?
| 5 |
Lithium for Unipolar Depression?
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Currently taking 450mg of Wellbutrin, 120mg of Cymbalta, and 2mg of Rexulti for my TRD (in addition to Buspar for anxiety and other meds for PCOS and MS). I also did a course of TMS from Dec. 2019-March 2020.
I've been experiencing a significant dip for about the last week, with persistent SI. In the past, I've experienced this whenever the efficacy of my meds is waning.
I just had an emergency phone appointment with my psydoc, and he suggested we try adding lithium to my existing cocktail. This is the first time I've heard of using lithium for unipolar depression. Is this unusual?
| 2 |
Another life shattered: The gut-wrenching journey of warrior Ryan, battling the syndrome induced by Lion's Mane
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https://youtu.be/iQhGWghPST4
| 2 |
Has anyone had any success with these so-called “nootropics” which literature says may be antidepressant?
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I’ve read on Wikipedia that several of these so-called “smart drugs” like Tianeptine, Pramiracetam, and NSI-189, which are all relatively easy to buy, supposedly have antidepressant properties.
For the record, has anyone actually tried any of these and noted some efficacy?
| 5 |
What to ask doctor?
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Hello! Looking for advice on medications to discuss with my doctor. Any time I have tried telling her something isn’t working, she will ask me what I want to take. I am overwhelmed by all of the information and options out there. I’m currently taking 300mg Buporpin and 25mg sertraline. Hoping to hear a few examples of what’s worked for you all.
I’ve been treated for anxiety and depression. I think since the pandemic, I’ve had extreme social anxiety which has led into some dissociation, NO motivation or care for things I once cared for. All I want to do is sleep and I have a hard time following through on things. I constantly am beating myself up in my head and have recently been working on my cognitive dissonance.
Celexa did nothing for me. Sertraline helped but made me a complete zombie. We lowered the dose and added bupropion to help with energy and motivation. Now I just feel like I’m only 25% better.
Thank you!
| 1 |
Taking Lexapro & Wellbutrin .. what's the next med?
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So I need a suggestion on a third med that can reduce anxiety more. To talk about what I've been taking, I've been on Lexapro (20mg) and Wellbutrin (150g) for at least three months, for both anxiety and motivation. Though my anxiety is better, it can still skyrocket when something bad happens, like when I make a mistake at work. So is there a 3rd drug that I can add to the list and talk with my psychiatrist about, that can further reduce the anxiety? I'd like to get to the point where I just don't care about what people think about me, or to be able to look at my mistakes as 'no big deal'.
I appreciate your help, thank you.
| 1 |
switching
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does anybody had depression after switching antidepressants? im in between switching to duloxetine from paroxetine. im worried cause its been almost 4 weeks on 60mg duloxetine and im sad as hell. anyone?
| 2 |
When does mirtazapine start to work?
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Been on it for 2.5 weeks and I have never felt more suicidal and lost please can anyone share experiences with getting better with this?
| 1 |
Potassium supplementation?
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I went to the doctors a month or so ago to get some blood tests done due to my mental health. Everything came back fine, apart from potassium which returned as 3.3mmol/l (Normal level - 3.5/3.6 - 5.1). My doctor didn't follow up on the result with any recommendation for supplementation, nor any advice to eat more potassium rich foods.
Would taking a potassium supplement be a good idea in this case? Will it cause any harm?
| 0 |
Anyone have experience with California rocket fuel and being pregnant? Effects on child, mother, ect.
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I found out I was pregnant and I’m reaching month 3 without any answers. I’ve been on crf for a year and a half plus lithium. My family doc immediately took me off lithium but is stumped and my psychiatrist dropped me because I haven’t been in contact for a year+. Family doc has no clue what crf could do to me or my child if I continue on it, as she’s had no patients in the past on it.
Side note, my pregnancy is already high risk so she doesn’t want to take me off my meds and cause the baby stress if she doesn’t have to.
Any input is appreciated
| 5 |
I have severely debilitating sensory processing issues. Sleep deprivation can temporarily cure it. With this in mind, what’s a long term solution I could try?
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Hello there, I am undiagnosed high functioning autistic/Asperger’s. My sensory processing issues are so bad that I can’t function in the real world very well, and I’m living in my parents’ house at 31. For me my problem is in social or loud situations I just can’t handle everything going on. Anything that can grab my attention is magnified so much that I can’t focus properly. For example, if someone is attractive to me, I can’t make eye contact. Even coworkers I work with for like 10 months. Also, I get physiological threat arousal from just like glances from people.
This leads to me not having hardly any friends, not being able to socialize well, burning out from jobs, and weirding people out
With sleep deprivation, my problems seem temporarily alleviated. It’s pretty cool in its own weird way. But that’s obviously not sustainable. What could I do to get this more long term?
I assume my gaba-glutamate balance is whack. I take many supplements for that already (taurine, glycine, and anti inflammatory stuff). I’ve previously had at least some positive response to: benzos (I don’t abuse them), nardil (MAOI), guanfacine, and memantine.
| 2 |
I keep failing med trials
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I keep failing med trials--either the side effects are unbearable or the med has no effect on me. TMS didn't work either.
Now I have a new doc who is very nice but I was unable to tolerate the first med he tried to change in my regimen. It made me feel more suicidal so I had to stop it.
I feel so bad to let him down, and he also knows I've tried a ton of meds with my previous docs so I worry what he will think of me.
Can anyone relate?
| 6 |
Has anyone tried trazodone?
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Just looking for experiences, reviews etc
| 6 |
Mirtazapine alternatives
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Hey, so Mirtazapine at 15mg stopped working for sleep after being on it for 4,5 years. Suddenly, it does not make me sleepy anymore or sedate me, the only effect that remains is an increase in appetite and slight reduction in anxiety. My sleep is quite bad ever since and I was wondering if there are any alternatives that are as effective as mirtazapine or if you guys know any medication that has helped them as much as mirtazapine with sleep, anxiety reduction and sedation. I've already tried Trazodone and it does not really work for me. Quetiapine works well, but I don't want to take an antipsychotic on a daily basis since my main problems are sleep and anxiety. I hope you have some good recommendations for me!
| 2 |
Can you guys share what you take for panic disorder/ agoraphobia?
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As of now I am taking
Lexapro 10mg
Ltheanine 600 mg
Still feel super anxious though ):
| 9 |
Weight gain on changing meds
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So I was Duloxetine 60 mg. It did wonders for my pain but my mood was eh still the same - sad and angry. My doctor changed it to Escitalopram 15mg and Pregabalin + Nortryptyline . I have gained around 4 kgs in just 1.5 months . I had worked hard to lose weight before the meds changed. Now, I'm scared that the weight is coming back.
I have observed that I eat food regularly now. Earlier, my appetite was low.
What should I do?? Change meds? To what
| 0 |
Im on 4 different medications and want to stop.
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Hey, I’m 25 years old and have been doing very badly for the past year or so. 3 months ago I was diagnosed with adhd and moderate - severe anxiety.
I went from not taking anything at all to being on:
Morning
50mg vyvanse + 10mg brintellix (Ssri)
Night
300 micrograms of clonidine + 12.5mg mirtazapine
I didn’t start on this all overnight, but slowly over about a month. I’ve now been on this regime for 4 months
My life has NOT improved at all. The vyvanse helps in ways I couldn’t imagine when it comes to my work performance and concentration, but I hate how it makes me feel. Like a robot. I don’t want to socialise on it at all.
Brintellix seems to have done nothing at all. If anything my anxiety is worse and is turning into depression. I’m weening off it now and have mild withdrawals and I’m scared I’ll have permanently changed my brain.
The clonidine, I don’t know if it does anything at all.
The mirtazapine helps me fall asleep in like 5 minutes (used to take 1-3 hours) but doesn’t help me stay asleep.
I have terrible health anxiety and have spent hours researching all of these meds and their possible side effects. I’m the type of person to research side effects and then convince myself I have them.
I’ve read so many horror stories from people withdrawing off of mirtazapine and ssri’s and think it will happen to me.
I don’t like this. I feel like my psychiatrist wants me to be on all these things but I want to stop. I’ve socially withdrawn so much.
I also can’t keep living my life the way I was before these meds (I’m still living that same life after these meds)
Please, any advice? Thanks
| 9 |
Any substance other than SSRI that can help with anxiety?
|
For some reason whenever I take SSRIs I end up over sharing and saying a lot of risky things that eventually get me in trouble.
But SSRIs are the only drug that help me with rumination and social anxiety.
Recently again I said few things that have gotten me in trouble and people are upset with me.
I have tried SSRI, SNRI, SPARI etc.
Most of them end up doing the same.
I want to get freedom from rumination without getting on any substance related to serotonin.
I take 300 MG bupropion for depression. Perhaps I would have to reduce it to 150 mg as it might be worsening the circular thoughts.
| 8 |
Memantine saved my life (for now)
| null | 7 |
Has anyone taken Mirtazapine & Duloxetine combined?
|
I'm on 45mg mirtazapine, was going to start 30mg duloxetine on top of it. Anyone have experience with this?
| 1 |
How to ask my doctor about gabapentin for depression
|
So maybe this post is out of pocket, but my mom gave me (20F) a 400 mg gabapentin, and I took it (albeit with a muscle relaxer (prescribed) and some benadryl) and I felt…. Normal. Not my normal, but what I feel like normal should be. It calmed my panicky suicidal thoughts. Ive been in such a suicidal spell the past week, and I do not feel suicidal right now. I dont know if its a placebo effect or if it has something to do with the combo, or if its just the gabapentin (benadryl usually just makes me sleepy if anything, and the muscle relaxers i take occasionally for my back pain) How would I ask my doctor about maybe taking this for my anxiety and depression? Obviously I took the gabapentin illegally, although I wasnt trying to get high or anything it still wasnt my prescription. Should I just tell him honestly what happened? Ive tried tons of antidepressants and they only mess me up, so if this could help… it could be life changing, I just want to be better. Any input is highly welcome.
| 11 |
Best anti-depressant to take with Vyvanse?
|
I have ADHD that I currently take Vyvanse for, chronic insomnia that I take trazodone for, and am going to be talking with my doctor on Monday about my worsening depression. I’ve been doing some research on my own and finding a lot of conflicting answers. I’m seeing that Vyvanse with SSRI is fine with no interaction, and I also see people writing about how the medications they’ve been prescribed are cancelling each other out.
I’m at a loss because I cannot stop my ADHD medication and I cannot take something during the day that will make me drowsy since I’m barely staying awake as it is.
Is there anyone who has found a successful combo that I can talk with my doctor about?
| 1 |
Is fluexotine injection a thing?
|
I was given an injection of fluexotine..is that a thing or they probably put an anti psychotic as well in it?
| 1 |
Loss of inner monologue and visualization. Any treatments?
|
I've been experiencing a loss of inner monologue and ability to visualize for around 7 months. I'm not sure how it started entirely. Alongside it, I've noticed issues with memory and very bad fatigue. I still have hypogenic hallucinations, sometimes when sitting from being very tired, but only outside of my head if that makes sense. Internally, I can't create an image or hear myself like I used to.
Another thing I would add is that people around me have described me as more instable and perhaps impulsive at times. I don't feel it personally though, I feel flat on the inside but my body is playing out things, I might lack awareness. I've also had comments from those close to me about dopiness, which has seemingly become more frequent. I agree with this, as it's become more difficult to keep with conversation and I sort of enter a 'nothing' state of no thought.
I used to have running thoughts; I could be very imaginative, far more creative. I would jump from thing to thing, have things to chat about etc. Now, I just feel almost meditative quite a bit of the time, but also very depressed and out of it. I experience impending doom and more severe panic attack.
I'm getting a little concerned with this and I'm not sure what treatments might resolve this. It feels as if I'm becoming more impaired by the day, forgetting things and no energy, speech seems a little wonky.
| 3 |
What are the absolute best treatments for SAD available, besides moving?
|
The past year I've realized my SAD is really really bad, in part thanks to some others on Reddit a while back. Gloomy weather destroys me. I usually have a full on breakdown around Dec/Jan, then around Feb I tend to go into a seemingly endless depression where I'm lashing out at others. I manage it better now, but in the past it's pushed me pretty close to taking my own life.
I've obviously tried multiple SAD lamps, from cheap lightbulbs to ones costing hundreds. None really help much. Years ago I got to the point of trying my second MAOI ever, Nardil. That didn't get me through winter either, and people say that's arguably the strongest AD ever. Starting before last winter I caved and started ketamine treatment, and that may have helped a little more (no breakdown!) but it was still far from easy. Hell I got to the point of leaving drone videos of summer-type weather on my TV all the time, and playing video games set in warm/nice places!
We're trying to move, but there's a chance I might be stuck in NYC longer, possibly through another winter. I'm scared of it, and don't really know what I'll do.
Without moving, is there any other options that have worked for others?
| 10 |
Is tms worth trying for severe depression/anxiety
|
..med resistant failed 4 weeks esketamine
| 3 |
Does pregabalin used daily have positive effects that are not apparent from a single dose
|
I was prescribed 75mg 2-3 times daily for anxiety. Picked them up over a month ago but haven’t started yet, as I’m afraid if they’ll work/have bad sides. But I have tried to take one capsule once in a while when my anxiety was really bad or to test it. It does lower anxiety somewhat but nothing groundbreaking.
So I wonder if you get better or different effects when used daily? I think it officially says it takes 1-2 weeks to work. Are there effects that appear after 1-2 weeks that you won’t get from just a single dose?
| 1 |
Gabapentin withdrawal vs SSRI withdrawal
|
To those who’ve been on both, which did you find to have a worse withdrawal? Even if you haven’t been on then which do you think is worse?
| 1 |
Pramipexole augments?
|
I’m on it for TRD. I do feel it’s working. Mood generally better, libido skyrocketed.
But still have serious issues with focus, fatigue and motivation. Probably undiagnosed ADD.
What are some safe augments for this? Wellbutrin? Ritalin? I’m concerned about hitting the dopamine pathway too hard. Perhaps a NRI?
| 3 |
Did shrooms actually help you with depression?
|
If you had a full-blown shrooms trip, did it help you with any of the following depressive symptoms: Anhedonia, motivation, energy, attention
[View Poll](https://www.reddit.com/poll/14s08v0)
| 5 |
Treatment resistant depression options
|
I've been depressed since I was a kid. I've done a lot to fix myself. I got diagnosed with Bipolar 2 and ADHD and I feel like my brain is broken.
A lot of times the depression hits because of a trigger, but I'm really sensitive to everything, and it seems like getting triggered is easy for me.
But some times, I'll be sitting doing one of my hobbies or laundry, it just hits so bad.
I've been using Marijuana to cope but it's not in a controlled environment and I feel like my dependence is increasing and I'll have to take it forever.
I've tried all the medications, and exhausted all options.
It feels like I need outside intervention because i can't seem to do it myself.
My doctor suggested TMS or Ketamine+EMDR. And I'm not sure what to choose. TMS sounds safer, but it seems it's not that effective, but I always see people talk about how ketamine changed their life. I want that.
What do you think? Have you tried it? What worked for you?
(Please don't tell me to exercise or meditate. I work out 5x a week and can't meditation. I need suggestions for these topics only)
| 9 |
Three healthy foods and herbs are important for maintaining mental health and good sleep, part 02.
| null | 0 |
Research study on depression (18+, International, Past experiences with depression)
|
Hi everyone,
This may not apply to many folks on here, but I figured I'd give it a shot anyway. I am currently looking to recruit participants to complete my online research study that is part of my dissertation in clinical psychology. My research focuses on understanding the concept of Fear of Depression Recurrence, which captures fears that people who are remitted from depression may have about becoming depressed again. The goal of this online study is to gain a better understanding of the construct and validate the psychometric properties of a Fear of Depression Recurrence questionnaire. We hope that learning more about fear of depression recurrence may present a small window into understanding depression relapse and thus lead to better informed prevention efforts.
**Interested? Here is some more information about the study:**
***Were you ever diagnosed with depression? Do you feel better now?***
The ***Stress and Developmental Psychopathology Laboratory*** at Concordia University is currently recruiting English-speaking participants for a study investigating the potential fears that people who are no longer depressed may have about their depression returning. This study has received ethical approval and involves completing online questionnaires that assess the fears you may have about your depression returning, as well as the severity, frequency, content, and triggers of these fears. It will also ask you for basic personal information (e.g., age, gender, race/ethnicity, occupation) and questions about your current depressive symptoms, other mental health concerns, beliefs about depression, coping strategies, and quality of life.
The online survey will take approximately **1 hour** to complete. All components of this study can be completed remotely, in the comfort of your own home. Participants who are eligible and complete our online survey will be entered in a draw to win one of **seven** $100 CAD Amazon Gift cards.
**If you are interested and you:**
✔ Are above the age of 18
✔ Have previously been diagnosed with depression
✔ Have no significant symptoms of depression during the last 2 months
Please click on the following link which will bring you to our pre-screening questionnaire to determine your eligibility. If eligible, you will be able to access our consent form and the online survey from this same link.
**Survey Link:** [https://concordiaccrh.qualtrics.com/jfe/form/SV\_8v5TiIGO7rSk5kG](https://concordiaccrh.qualtrics.com/jfe/form/SV_8v5TiIGO7rSk5kG)
| 1 |
Mental health "Recovery"
|
If there was such a thing as mental health recovery in my case.
I would be mindful and do the following
* Being a no show to groups and activities, I do not want to show up to. (As leopards don't change their spots) You never gonna get me to show up to an NHS run mental health support group, they would have to pay me quite a lot just to attend once, and neither would I turn up to Mind, Rethink or Library run groups.
* Plus, I don't really like leaving my house more than twice week anyway, it's not an anxiety or being scared, I just don't like it.
* Having a very peaceful indoor way of life, with little job on the side for a few days a week.
* Switching that mobile phone off whenever and wherever I feel like it is work has a special mobile/radio to use.
* Having those days when you go off the rails a bit \*Give the opinion you don't give rats about anything at all!
* Continue with OMAD for life, giving up sugar and perhaps a few other unwanted items.
* Finally, I completed my degree even if it is in psychology it will do.
* Get back into some sports I can do locally or from the comfort of home.
| 1 |
Pristiq problems - where to from here?
|
I've had recurrent major depressive episodes for decades and anxiety that ranges from mild to panic attacks and 'can't leave the house' episodes, diagnosed as autistic 5 years ago and ADHD 2 years ago.
Currently taking Pristiq 100mg, lamotrigine 200mg, dexamphetamine, metoprolol 25mg x 2, Zoely (birth control) for PMDD.
I've been stuck in a depressive episode for a year or so with fairly consistent passive suicidal ideation. My dr tried adding back mirtazapine, didn't help, so discontinued that. Then increased the Pristiq from 50 to 100mg which hasn't helped a whole lot and has increased my anxiety hugely.
The metoprolol was added a couple years ago by a cardiologist for inappropriate sinus tachycardia that was worsening my anxiety, and I'm fairly certain the Pristiq is making it worse but I don't know where to go from here. I have a psychiatrist I've been seeing for a long time but his suggestions were either increasing the Pristiq again or cross tapering to fluoxetine. Another suggested swapping to duloxetine stating that the discontinuation is easier (which from what I've seen is entirely incorrect). So I'm turning to you all for some lived experience advice.
I've tried a number of medications in the past, most were somewhat effective but pooped out, including escitalopram, sertraline, mirtazapine (as mentioned above), and agomelatine. I'm located in Australia which does impact the medications available to some extent. I'd ideally work towards discontinuing the Pristiq entirely but I'm looking for suggestions for alternatives to trial and/or something to augment the current regimen to help get me there.
Please help - happy to answer any relevant questions as well.
| 1 |
Watch THIS documentary if you want to tunnel out of your PTSD
| null | 3 |
Aripiprazole safety?
|
Hi. My doctor suggested I’d try a low dose of aripiprazole to potentially increase dopamine. However, when reading the package leaflet I noticed ”sudden inexplicable death” as one possible side effect. Is this something to be concerned about? I briefly DuckDuckGoed it and learnt there indeed seems to be some risk of QTc prolongation when it comes to antipsychotics. However, it seems to be dose dependent and I would be supposed to take only 2.5 mg every other morning. And I’d assume it’s very rare anyway?
Probably a silly question but I’m not in good place right now; not only I have no motivation to do crap, but I also seem to be afraid of everything.
| 9 |
Anyone here add SSRI to Clomipramine?
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I’m adding Lexapro to 150mg of Clomipramine. Anyone else do this? I have treatment resistant OCD and depression. I’m not going higher on the Clomipramine because it worsens my memory at doses above 150mg.
| 2 |
Hallucinations on clomipramine??!
|
Has anyone had that, feeling tike someone is tapping the bottom your foot with fingernails or making your feet move? Even trying to make your legs move and it feels like they are but they’re not? I saw someone who died a year and a half ago when I closed my eyes and it felt like he was pushing me on a swing. I didn’t see it but when I closed my eyes he flew us on a …well I’ll leave it there for the moment. You guys probably think I’m nuts…anyone…bueller…
| 2 |
Anyone prescribed Wellbutrin/Buproprion along with their SSRI/SNRI to help lose weight?
| null | 2 |
Ozempic
|
Is anyone taking ozempic for the weight loss and does it interact with medications or exacerbate symptoms?
| 0 |
Amitriptyline, Mirtazapine & ADHD. It's been a long journey, but it's still not right.
|
Hi all,
I've been through a few antidepressants and I would appreciate your thoughts.
***(some background)***
>**SSRIs** do not work. *(sertraline, escitalopram, fluoxetine)*
>
>**SNRIs** work, but their half-life makes me feel like a drug addict coming down if I miss my dose within a few hours. *(desvenlafaxine, venlafaxine)*
>
>**NDIs** seem to not work. (sr bupropion)
>
>**TCAs** seem to work but, I feel slower than I have been. Especially with my semi-recent ADHD diagnosis. They seem to be clashing. *(amitriptyline)*
>
>My psychiatrist I feel is against antidepressants and it seems to me that his opinion is that my depression and anxiety are from my untreated ADHD through adolescents. This is why I have been questioning my current treatments.
>
>Currently, I am on **75mg Amitriptyline** (general practitioner prescribed), **60mg Vyvanse** and NovoRapid. (as I am a type 1 diabetic)
My psychiatrist told me I should be lowering my amitriptyline to 50mg and eventually to nothing. He explained that the anticholinergic effects of the drug are counteracting the vyvanse. But, my depression and anxiety have not been an issue on the Amitriptyline. *He did mention* ***Mirtazapine*** *as an antidepressant that has a low incidence of sexual side effects, which, I have had with pretty much all of the antidepressants I have tried.*
My GP and I have come to the conclusion that I will likely need a drug that has some sort of serotonergic effect for the foreseeable future. This seems to be challenged by my psychiatrist.
I have been looking into Mitrazpine after my psychiatrist mentioned it. *(I actually asked my GP about mirtazapine before he said I should try amitriptyline)* It seems to have the same efficacy as amitriptyline with a better side-effect profile. Especially with **weight gain**. Which has been a big struggle with amitriptyline.
**Has anyone been on mirtazapine and experienced any lack of concentration, forgetfulness, lack of motivation or sleepiness after being on the drug for a period of time?** *(these are a few things I have noticed with the amitriptyline)*
**Weight gain?** *(I have gained 13kg on amitriptyline)*
**ADHD and mirtazapine?**
**Any insight into this is helpful as I can't look at the pharmacology and studies forever!**
Thank you all!
​
| 9 |
Prozac, wellbutrin, lamictal
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So I'm on this combination. Prozac increases serotonin, wellbutrin increase dopamine. I have read lamictal decrease those. Is it pointless taking these 3.
| 2 |
Zero clue what is going on
|
Hello all, I’ve been here before but first time posting just bc I want to get a idea of other people’s thoughts on this.. so I’m going to try to make it simple and short as possible.
I was diagnosed with anxiety in 2nd grade, I had a panic attack watching SpongeBob out of no where with family that is my earliest memory of a panic attack.. my anxiety quells from a major fear of vomiting, idk why I just had bad memories of it. So I was prescribed 50mg Zoloft (sertraline) daily, never really did anything for me but took it consistently throughout my years from elementary, middle, and high school. Going into college is where all hell broke lose. I stopped taking it at this time. I didn’t notice anything difference but a lot of factors come into play which would lead to what I am getting at with depression and a official diagnosis. My dorm was religiously too hot, ac was not really a thing, and in winter it was a desert. My sleep went from getting 8 hours a night to 4-5, sometimes 6. Only 8 when I was horrendously tired. My motivation that I had for lifting (used to be a extreme gym goer, bodybuilding goals (natural not taking steroids or enhancing subs), I was driven and extremely goal oriented. Then after the years my routine would thought college to now would decline and go into absolute hell. I have no motivation to workout, do anything, I feel like a husk. I went to a psychiatrist and I did a DNA test to see what works best and it was sertraline however it didn’t work the best and we switched meds. Here is everything I have tried and I am requesting to get a MAOI after some research.. im losing some hope that I will get back to being how I was and wanted to see if anything you guys recommend anything or what options I have
What I have tried in order:
-Wellbutrin (max dose)
-sertraline (max dose)
-Effexor (max dose)
-lexapro (max dose)
-paxil (mass dose)
-ketamine IV drip
-seroquel (sleep aid)
-modafinil and armodfanil
Something’s to add:
-getting out of bed is hard
-hygiene is hard
-loss of motivation
-loss of caring about myself
-feeling bad about myself
-I’ve been tested for sleep apnea and hormones, everything is fine, blood panels and sleep studies done
-I check off the box literally on everything for adhd so idk if that is something to take in
Thanks all if you took the time to read :)
| 8 |
Probably been shared before, but a useful resource for suggested cross tapering protocols between ADs + other psych meds
| null | 5 |
Cycling an SSRI - any experiences?
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Hey all, I'm at my wit's end trying to deal with the sexual side effects of SSRIs and I'm trying to come up with a creative solution. I have tried many different SSRIs (lexapro, zoloft, luvox, viibryd) and they all of the effect of causing extreme sexual dysfunction/numbing, even at a very low dose. I've tried adding wellbutrin and buspirone as add-ons - no effect whatsoever.
I'm currently on 10mg of prozac, which I actually like as an antidepressant. For me it's energizing, does not cause anhedonia, and helps significantly with my anxiety and panic symptoms. But I just don't know how much longer I can take the genital numbness and anorgasmia.
Out of desperation, I'm considering an unorthodox dosing schedule where I e.g. take the 10mg of prozac for two weeks or a month and then cycle off of it for the same length of time. The goal of this would be to give myself a window of time every month or so where I could actually enjoy sex with my partner. Due to the long half life of prozac, I doubt I would experience any withdrawal symptoms, but obviously this could be a concern.
Has anyone here tried cycling an SSRI like this in order to make the side effects more tolerable long term? What were your experiences like?
| 5 |
Need to feel how I felt before, any advice?
|
So I’m taking 2 meds, Viibryd and Welbutrin
At this current point I am not depressed / haven’t been for 1.5 months. My mood shifts every several months…. my clinical team thinks I have bipolar disorder - not sure how much I agree with this assessment but I guess it’s possible.
Anyways, despite me not currently being depressed, I am finding life / myself very boring, and I’m literally **tired ALL THE TIME** (not from meds, I’ve always been like this) . I workout too btw, so it’s not even that I’m sedentary.
There are periods I get where I’m not only not depressed… I’m optimistic, motivated, hyped up, social / wanting to talk a lot, not ridiculously tired all the time, etc.
I’m wondering how I can achieve **that** again. The problem for me is that it just *happens*, I’ve never been able to control when it starts or ends.
Any tips? I don’t want to just be not depressed, **I want to actually feel good**… want to feel that drive to connect with others, etc.
| 0 |
Mirtazapine vs Lexapro
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Anyone have experience taking one or the other?
| 3 |
Fluoxetine didn’t work, so I’m taking Olanzapine now. Thoughts?
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Hey all, I (18) was treated by my family doctor with Fluoxetine to treat with my depressive behavior/thoughts and due to it not appearing to work for the month that I took it (suicidal thoughts increased, relapsed into depressive behavior more frequently, started self-harming, and my sleep schedule worsened) my doctor instead got me on 5mg of Olanzapine.
I took my first tablet last night and I went to bed at about 1am, compared to the typical 4-5am. I did, however, notice that today I was often very tired and I ended up not being able to find myself getting out of bed for the majority part of my day.
Will this be a problem? Any opinions or past experiences? Anything is appreciated
| 2 |
Clomipramine…weird side effects
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Hello, I have been taking clomipramine for OCD for a short time now and I am wondering if these side effects are ok in the beginning and go away over time
,ajoy domstipap
major donstipation. ( cons…)
low blood pressure when I stand up after being in bed,
I mean the tunnel darkens and then it starts to be ok
but twice I found myself on the fkoor
a new one, shaky hands, typos and unusual for me - makes it very challenging ti type
and i read that doing workout like moved wit( your arms and legs raises blood pressure,
when I tried it today again I saw a little of the darkness circling im then I started shaking my arms and legs really fast my bed is up on some risers so I leaned badk into in so my back was flat amd I think my arms slowed down but my legs kept going dor another 10:seconds or so, kind of exhaustimg but I #tood up and my balance was way off as I staggered down the hall
just wondering if these are common or transitory and I’m concerned about the hands
thank you
| 3 |
Trintellix 20mg to Lexapro 20mg - tapering experiences?
|
I'm currently taking 30mg of Trintellix. Got up to this dosage since starting in Feb.
Unfortunately it doesn't seem to work anywhere near as well as Lexapro for anxiety (although it does seem to work well for depression). I'm already at an unusually high dosage so this seems like the right point to call it quits.
I'm of course going to ask my doctor for advice, but wondering if anybody has done something like a 20mg Trintellix to 20mg Lexparo cross taper and if so could share any tips and the protocol their doctor prescribed to transition between the two meds?
(I'm of course taking a bit more Trintellix than that but figured the transition plans would be similar)
TIA
| 1 |
2.5 mg olanzapine as add on to ssri
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For anxiety, intrusive thoughts and sleep at night
Any experience?
Thanks
| 6 |
Trazadone psychedelia
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I was recently prescribed trazadone 50mg for sleep snd told start at half a pill so 25mg to go slow so hopefullyi didnt have the hangover effect.. I took 25mg last nigh and i felt it in about 20-30 minutes I felt a little tired but i noticed my thoughts were drastically changing I was thinking about how miserable I was and how the reason i feel dead inside and why I feel so foggy forgetful and like im in a daze and have no passion is because I am in hell. I had thoughts that i do not realize im in hell and I slowly looked back at my life and how miserable it is and it felt like a veil was lifted and i got really scared realizing this and I felt like i wanted to scream. I then took another half (25mg) then i went to sleep finally and had the weirdest dream in the world and i woke up at 6am tired as hell. Anyone else had this experience or similar?
| 1 |
Johns Hopkins survey on HPPD: Help us uncover new insights into the condition and its treatment
|
Researchers at Johns Hopkins are conducting a survey to better understand the experiences of people with HPPD (Hallucinogen Persisting Perception Disorder). HPPD is a condition where people who have used hallucinogenic drugs experience ongoing visual disturbances, such as seeing halos around objects or seeing colors more vividly. This survey will ask about risk factors, symptoms, treatment experiences, and how HPPD has impacted your life. Your participation in this research study can help improve our understanding of HPPD and lead to better treatment options for those who are affected by it.
​
[www.HopkinsPsychedelic.org/hppdsurvey](https://www.HopkinsPsychedelic.org/hppdsurvey)
​
Protocol: IRB00384491, Principal Investigator: Natalie Gukasyan, M.D.
| 2 |
Selegiline For ADHD-like Symptoms?
|
Hi there,
I wonder if anyone with ADHD is taking Selegiline. Does it help with Symptoms like sensory overload, being easily distracted, brain fog, impaired impulse control? I would love to hear some experience reports
| 2 |
Just a weird observation, but isn’t it strange how much docs refuse to deal with MAOIs but have no problem with combo therapy which is basically the same thing?
|
It’s just always struck me as weird that the standard practice is: SSRI (Prozac), the SNRI (Effexor), then SNRI + NDRI (wellbutrin), then SNRI + NDRI + Stimulant or Antipsychotic.
But never, ever an MAOI.
What is the difference?
| 11 |
Sertraline, Lithium, Klonipin and Abilify no longer keeping me functional.
|
I graduated grad school a month ago and have been in bed since. My bedroom is a nightmarish mess of garbage and laundry. I haven't showered in weeks.
My psych and I have been playing around with dosing of my meds but it has not helped. I have an appointment for TMS but the logistics just don't work out.
| 5 |
Idk why i feel like this
|
Today is my birthday and i feel so depressed and so sad about this day. I am alone and hanging out with myself doing nothing just laying on my bed. Why i am not happy about my birthday, usually people feel so excited and are so happy but i am the opposite i feel just bad and wish that i was never born
| 9 |
Major life change can be good for you.
|
I've been on every antidepressant under the sun. SSRIs, SNRIs, TCAs, RIMAs, stimulants, the works.
But I'll let you guys in on a secret I wish I learned earlier in life... if your lifestyle makes you miserable, medication will not fix that. I know from experience. If you hate your life, no medication in the world is going to make you magically start liking it.
Medication opens a door, but we have to be the ones to walk through it. The right combination of medications can make it *possible* for you to be happy, but you have to also create the conditions in your life where you actually *can* be happy.
I consider my depression mostly cured, or at least under extremely good control, and I would attribute maybe 30% of that to my meds (27mg methylphenidate for depression and 2x150mg pregabalin for anxiety). The rest is attributed to the fact that my life today is basically nothing like how my life was a few years ago.
I divorced my emotionally abusive ex-husband, spent time reflecting on who I am and who I wanted to be, remodelled my career into something I love (bioinformatics), started leaning *hard* into my truest self instead of running from it, and stopped giving a shit about what other people think of me. I guess that last one is the bonus of turning 30.
Don't chase after the life script you think will appease others. Do what you actually want to do.
Want to move away to another city or province/state and start anew? Do it. No time like the present.
Want to declare yourself a queer furry and build a friend group of others like you? Do it. So what if people think you're weird, you do you.
Yes, I know it's an oddly specific example. It's me. But the principle applies overall - pursue what you want to pursue, and fuck anyone that stands in the way of it. Believe me, you'll be 1000x happier for it. I sure am!
| 34 |
What helped you get out of depression?
|
Working out, eating clean, therapy and medication didn't really do the trick for me. What did it for you?
| 5 |
Mirtazapine - Remeron: Can it be used for sleeping only?
|
Hi,
Can Mirtazapine (Remeron) be used to help one sleep only, every now and then? Instead of using it daily as an antidepressant?
Thanks!
| 1 |
Ketamine Therapy
| null | 17 |
Maybe it's not depression. Maybe it's just you.
|
When weeks turn into months turn into years, when you fail enough treatments, you will inevitably start to wonder, is it just me? Have the antidepressants been working this whole time and this is who I fundamentally am as a person?
You have been depressed your entire adult life. At the end of high school it crept up on you; you didn't even notice it at first. You pushed your friends away, your grades dropped from A's to B+s (a normal thing considering it was the second half of senior year and you were biding time), and you spent more time alone. You refused to admit something may be wrong; you were just having a bad year. But it festered, the rot spreading over years until you were a shell of who you once were. You were failing out of university. You had only a few friends. The only people who loved you, loved you by requirement. You felt alone, and tired, and empty. You were put on meds that triggered a suicide attempt and were put on new drugs. You told yourself they helped even though in hindsight, they made things worse. You spent the next several years trying to scrape by every semester while alternating between different treatments. You even took a year and a half off of university where you lay in bed and didn't do much else. Every semester would start the same: you would convince yourself that you were fine, that you were just being lazy and needed to try harder. The work wasn't hard, you just needed to actually do it, something you found impossible to do. You had tried Zoloft, Wellbutrin, Amphetamines, Pristiq, trazadone, supplements, TMS, genetic testing, a clinical trial; and yet you still felt the same. It is incredibly disheartening to watch videos of people sobbing about how a treatment changed their life when it did absolutely nothing for you. You start to doubt yourself, even knowing you were dealt a bad genetic hand and that depression runs heavily in your family.
Maybe TMS did work.
Maybe you aren't depressed at all.
Maybe it fixed your depression and all that remains is your lack of willpower.
You feel pathetic.
You feel ashamed.
You feel like you have ruined your entire life before it has even started.
It takes a lot to admit to yourself that you are not ok. That you are one semester from failing out of school and that you have been lying to everyone in your life, telling them that you were doing well because you were too embarrassed to tell them that you were failing at things you would normally find easy. After an argument with your psychiatrist where you begged him to put you on an MAOI, an entirely new classification of meds for you, he finally obliges. It does nothing, but at this point you are used to it. A genetic mutation in the CYP2C19 gene requires you to take such high doses that when you would list your medications, doctors looked at you with shock and asked "why on earth are you on that dose?" (Apparently 400mg of Wellbutrin is not the norm.)
But then one day, after moving again to the highest dose, you get out of bed on time. You make tea. You get work done. You read. You knit. You think it's a fluke but it happens again, and again, and again. You are by no means cured; you still have bad days and you are still depressed, but for the first time in 6 years you actually feel functional. You scramble to do the things you were too anxious to do a few months ago. You realize you have been exhausted for 6 years, and for the first time, you are not.
I know how it feels to hear of the magical treatment that “cured” someone's depression, maybe even most people's depression, but did absolutely nothing for you. It feels like you are broken, that it is your fault, and if you just tried a little harder, you could put your life in order and feel whole. I don't want to do that. What helped me may do nothing for you– but I do want to tell you that it's not you, it's most likely your brain chemistry. As someone who had completely lost hope and believed that I was stuck being a person I hated forever, switching medications changed my life. It was gradual, but I feel human again. I no longer feel like the decaying husk of a person. Even though it’s subtle, it feels like magic.
I don't know if my treatment will work for you, or what treatments will. There's a good chance mine won't, especially since it is rarely prescribed. What I do want to remind you though is that it's *not* your fault, you are *not* alone, you are *not* crazy, and if you are still feeling like absolute shit, **try something different.**
| 54 |
Pristiq and join pain?
|
Has anyone had joint pain from taking Pristiq? Both knees been aching since about 2 weeks in on this at 25 mg. At 50 mg for about 5 weeks now still have the problem. I figured it may go away but hasn't. Not sure if I should try something else or what to do.
| 2 |
3 Weeks on Abilify (2mg) and 4 days on Clomipramine (25mg)
|
I was doing well on just the Abilify but ever since adding in the Clomipramine I have been having these waves of deep emptiness and maybe grief. This is a new sensation feeling for me. It's very uncomfortable. I am trying to figure out the cause.
Has anyone else experienced this on either drug? I also finished my 3 month slow taper of Viibryd.
I wanted to try the Clomipramine for obsessive negative thinking.
I have reached out to my doc and waiting to hear back.
Any thoughts?
| 1 |
Stablon help.
|
Ive been on Tianeptine sulfate 75mg for about 5 years. I am running out and have an amazing job i wish to start, but fall apart if I am not on my meds (why is life so cruel, as when I started you could get it on Amazon basically, but people abuse it).
I can no longer get a legitmate supply and also would like to take proper pharma grade pills.
I have tried several other antidepressants but have many side effects, especially when I try to come off sulfate. (Insomnia, severe anxiety, zero stress resilience)
Does anybody know how to get this prescribed. I am in the UK, but willing to travel in Europe? I think i would need 3x a day dosing which is what is recommended. As 75mg sulfate equates to about 30mg sodium (stablon).
Does anyone know how I could go about this? I can go to France but know it is quite difficult there and they only give a 28 day supply. Are there other parts of Europe. Also please DM me for details, ordering from Asia. I can see some but it is very expensive. 10 tablets for $10 dollars and you need 3 day, also quite a lot of boxes which is suspicious.
| 5 |
No wonder psychiatric prescription practices are garbage
|
Even Chat GPT, which always avoids saying anything controversial, lays it out here:
https://preview.redd.it/0u4eiw4xzm8b1.png?width=678&format=png&auto=webp&s=9aa10b8c55c471e195a941233c9ebb2b965a52b4
​
| 0 |
would love to hear some opinions about my stack
|
been dealing with depression and anxiety for several years. main symptoms are fatigue, low mood, agoraphobia. i workout/eat pretty well and am in therapy but if theres some other ways to help my situation via better supplementation I'm very open to that.
currently taking daily:
vitamin d 5000 iu
probio mood sap probiotic
nordic naturals omega 3 fish oil - started taking these after listening to dr huberman podcast on depression
creatine 5g - taking this to help my workouts as well as possible anti-depressive + energy boosting properties (also started after hearing huberman speak on this)
ancient nutrition green scoop - recommended by a naturopath i am seeing (honestly not sure if this does anything or is worth the $$)
pure encapsulations NAC - also recommended by a naturopath (it seems to be helping my chronic allergies)
let me know what you think! very open to suggestions as I'd like to eliminate anything that I don't need/add in anything else that could help
i'm also on an ssri right now and currently tapering off as I don't think it has helped me. I am waiting on getting off completely before experimenting with 5-htp/ashwagandha/other potential calming supplements
thank you
| 1 |
Parnate
|
Have any of you guys tried Parnate or the generic version for Ahedonia or depression?
| 9 |
Experiences with Zembrin (Kanna extract)?
|
1. What's your experience with it? What do you take it for, what effects do you get (mood/depression, anxiety, sociability/talkativeness, energy/drive, stress/relaxation, cognition, sleep etc.)?
2. What dose do you use?
3. Does it work used only on occasion / if needed? I mean, must it be taken daily so it builds up in your system until it can and does work (similar as antidepressants) or is it something that works right away and can be felt after first time dosing?
| 4 |
Mirtazapine: I can't get out of bed, terrible brain fog
|
I have been taking mirtazapine for 2 years now, it works amazing for sleep. I used to not be able to fall asleep and then get so stressed out at night that I fell into this vicious circle and just stayed awake entire nights. It definitely improved my sleep, especially before tests or presentations.
The problem with it though is that it's summer now and I just.. can't get out of bed. There's time where I just slept till 15.00 in the afternoon. I slept between 12 to 18 hours some days. It messes me up, gives me terrible brain fog and I am just less than human, like watching my life as a movie almost.
I quit for three days and feel how I used to feel, energetic and happy. Albeit a bit restless, but I have accepted it and it feels better than having to drink 3 cups of coffee before being able to follow a regular conversation.
What are your experiences?
| 9 |
Adderrall - the “cause” or a “solution” to my chronic depression?
|
Hi guys- just wanted to share this post as I’ve been thinking about this a bit more recently- regarding adderrall and my depression. Wondering what others may have experienced.
Currently I’m diagnosed with MDD, ADHD, and OCD.
Though I’d be lying if I said I remember the details from this point of my life well when I began taking adderrall, here’s what I recall - I’ll do a timeline so it’s easier to read.
20 years old- started feeling chronic depression and having suicidal thoughts…
This is when I also began experimenting w my moms adderrall which I felt helped me focus like none other..,
This was also when I felt like my OCD was at its worst (didn’t know what it was at the time)
22- got sober - felt like depression lifted for first time in years. Intrusive OCD thoughts ceased.
I still took adderrall but was very aware that if I went even a day without taking it, I was literally in such a low state that I could almost not bear it. Adderrall had an immediate effect on my mood but going without was NOT good for me.
27- depression and OCD got a lot worse again. Still taking adderrall
28-29 - depression started lifting a bit - would be totally lying if I remember any sort of timeline or cause and effect - I just know for maybe 2-5 months I weaned off adderrall during this time.
Even when my depression wasn’t nearly as severe, I started taking adderrall again and decided the reward of increased focus and productivity was worth it for me.
35-40- still take adderrall and struggle w chronic depression and OCD and have for most of last 5 years - I don’t have the crazy withdrawals I used to when it comes to adderrall - I can go days without taking it and don’t notice a huge change aside from eating more.
I tried taking some “holistic adderrall alternative” while taking lower adderrall dosage, and it didn’t do shit for me. Taking higher dosage of adderall can still help improve my mood and productivity a bit, but typically I need to take more than prescribed. It’s been hard getting my psychiatrist to agree to increasing dosage even though I’ve taken it without abusing it for nearly 20 years.
Basically, here’s the gist of reason for my post and what feels like my challenges.
* I want to greatly reduce my depression symptoms -
* I wonder if adderrall may have triggered more depression in me as well as more “positive feelings”
* Adderrall continues to, in my experience, help me get going with my day and be reasonably productive
* I do not want to stop taking adderrall, but if it somehow became very obvious that it was the “core” problem of my depression and I could find a sufficient alternative that helped me be productive still and less depressed, I’m all ears!
| 2 |
Academic Research on Depression (18+, International, Past experiences with depression - repost)
|
Hi everyone,
This may not apply to many folks on here, but I figured I'd give it a shot anyway. I am currently looking to recruit participants to complete my online research study that is part of my dissertation in clinical psychology. My research focuses on understanding the concept of Fear of Depression Recurrence, which captures fears that people who are remitted from depression may have about becoming depressed again. The goal of this online study is to gain a better understanding of the construct and validate the psychometric properties of a Fear of Depression Recurrence questionnaire. We hope that learning more about fear of depression recurrence may present a small window into understanding depression relapse and thus lead to better informed prevention efforts.
**Interested? Here is some more information about the study:**
***Were you ever diagnosed with depression? Do you feel better now?***
The ***Stress and Developmental Psychopathology Laboratory*** at Concordia University is currently recruiting English-speaking participants for a study investigating the potential fears that people who are no longer depressed may have about their depression returning. This study has received ethical approval and involves completing online questionnaires that assess the fears you may have about your depression returning, as well as the severity, frequency, content, and triggers of these fears. It will also ask you for basic personal information (e.g., age, gender, race/ethnicity, occupation) and questions about your current depressive symptoms, other mental health concerns, beliefs about depression, coping strategies, and quality of life.
The online survey will take approximately **1 hour** to complete. All components of this study can be completed remotely, in the comfort of your own home. Participants who are eligible and complete our online survey will be entered in a draw to win one of **seven** $100 CAD Amazon Gift cards.
**If you are interested and you:**
✔ Are above the age of 18
✔ Have previously experienced an episode of depression
✔ Have no significant symptoms of depression during the last 2 months
Please click on the following link which will bring you to our pre-screening questionnaire to determine your eligibility. If eligible, you will be able to access our consent form and the online survey from this same link.
**Survey Link:** [https://concordiaccrh.qualtrics.com/jfe/form/SV\_8v5TiIGO7rSk5kG](https://concordiaccrh.qualtrics.com/jfe/form/SV_8v5TiIGO7rSk5kG)
| 2 |
does pramipexole cause heart issues?
|
I saw that mentioned here, are they correct? https://www.reddit.com/r/Nootropics/comments/e1ogal/pramipexole_any_nootropic_benefit/f8r21h6/
If so, what would the cause be?
| 1 |
Started Clomipramine 2 Days Ago and Feeling Worse than Just Abilfy
|
So I started Abilify a couple weeks ago and was doing pretty well on that. I was also tapering off Viibryd so I was on about 10 mg of Viibryd for most of the last couple weeks. I've now come off the viibryd completely and started Clomipramine.
I'm not feeling as good, less energy more blah feeling. I of course can't determine if it's a side effect from the Clomipramine or if it's due to being off the Viibryd but I feel like 10 mg is so little after being on 40 mg for two years that that wouldn't make that much of a difference. Anyway I'm thinking of coming off the Clomipramine and trying to go up on the Abilify. Thoughts?
Should I give Clomipramine more time?
| 1 |
A friend of mine has very similar symptoms to me (if not identical) but meds didn't work for him. Does that mean that the meds won't help me with those symptoms?
|
I know that everyone can have very different reactions to medications, but I'm a bit apprehensive about it this time because with a friend of mine we share a lot of common symptoms, ideas and beliefs around it.
Should I even bother trying it if they didn't work for him?
| 0 |
What medicine helps with motivation but doesn’t cause jitters or fast heart rate in someone sensitive to medicine?
| null | 14 |
Only Benzos helping somewhat
|
I tried a plethora of meds incl. ssri, snri, esketamin et al. Didn't do shit at best, made me extreme suicidal at worst. Only Benzos helped me reliably.
Did somebody have the same expierience? And if yes, what else did help you?
| 8 |
Does anyone else have trouble motivating themselves to make a healthy meal sometimes and end up getting gi issues as a result?
| null | 3 |
Mirtazapine quit, weight loss quiestion
|
Hey guys, im in the taper of the mirtazapine because i put on about of 16 kg in 3 months, i was also overweight from taking Paxil before but long story short i tooked in a combination with Paxil, now i tape both because not helped with my Post Covid depression, fuck it, it just made me felt exhausted and i don't want it anymore, so you guys how much weight you lost after quit that poison?
| 3 |
2 mg Abilify taper ?
|
I was on it for 3 weeks . My
Psychiatrist doesn’t believe anything has to be tapered but trying to find some answers. I know it’s different for everyone
| 1 |
Does low dose esketamine cause shaking/jitters or a high feeling in anyone sensitive to certain medication
| null | 2 |
Looking to start a med effecting motivation and dopamine. Advice needed
|
Hey everyone. I'm looking to start a med that is uplifting and motivating. I've tried buproprion before and I didn't do well on it. I have tried SSRis and SNRIs so not interested in those. Also not interested in Adderall or Ritalin. I was reading about combos of maois+TCA, sounded kind of interesting. I struggle with ahnedonia, depression, lack of motivation and hard time focusing. Any other drugs you can recommend similar to Wellbutrin etc? I was reading about pramipexole, anyone have experience with that? Thanks for any advice!
| 6 |
Hello everyone, I’ve been taking lexapro for about two years now and just recently added Wellbuturin SR to my regiment. Does anyone have any feedback of this combo and how it worked for you?
| null | 10 |
What else to try?
|
I'm dealing with chronic pain, extreme daytime fatigue, and depression.
I've tried about 10 different SSRIs so I don't really want to try any more, I feel like at this point we have proven that they fundamentally don't work for me.
I've also tried magic mushrooms, TMS, and I'm actively having weekly counseling appointments.
Do you think I should try tricyclic antidepressants? Or maybe MAOIs?
I'm getting desperate, not able to function, my whole life is kind of falling apart.
| 3 |
Rexulti withdrawals after a few doses?
|
Iv decided im going to stop rexulti due to side effects, I was taking 0.5mg and GP said will be fine to just stop, but being very anxious about meds and side effects already im worried about getting withdrawals.
I wont be able to get in contact with a psychiatrist for a few days.
How did others fair when stopping after a short period?
| 1 |
Is anhedonia essentially unrecoverable from?
|
The reality seems to be that very few people recover 100% of the reward they used to have even if they improve. How the hell do you cope with life knowing you will never enjoy life like others again, whats the point?
| 29 |
Aripiprazole 5mg increased appetite
|
Hey everyone,
I ve been seeing a psychiatrist for the last two months. I told him that I need a med that will boost my energy and help with depression and anxiety but I won't tolerate neither any effects on libido nor weight gain.
I ve tried too many meds and the best on for me was fluotetine by far. But it caused libido and sexual issues so I stopped after 2 years.
I know that if a med causes either of these two sides even if take it to get better sooner or later I ll stop it. So there is no point in starting it in the first place. My condition is chronic so it's not like I ll take the med for a while and then stop.
Anyway so the doc prescribed trintellix which I ve taken in the past and although it didn't cause libido or weight gain issues it didn't help at all and made me more angry. The doc insisted that it's not from trintellix and he said to take it at 10mg along with 5mg aripiprazole.
I read about aripiprazole increasing appetite and weight so I didn't take it. Took trintellix for 2 weeks and after experiencing all the symptoms that made me stop it earlier I stopped it (I had taken trintellix previously for 8 months and those sides didn't get better)
So I went to the doc again yesterday and he got mad that I didn't take them and said things like you don't think I know these meds and how they work etc and also that there is no possibility that 5mg of aripiprazole will cause appetite increase or weight gain.
I thought that ok he is a doctor (and considered a good one) so if he is so sure I might give it a try.
First day today I took the meds in the morning and even though I ate lunch one hour later I was hungry again, I held myself but at two hours I ate another snack. I am feeling more hungry, so what do I do? Give it time? Will that subside?
What do you guys think?
| 1 |
Am I resistant to all forms of anti depressant & therapy? Sometimes I feel like it’s my time to go.
|
Hi, so I’ve suffered with severe depression since I was around 9-11 years old, that was around the age I first attempted to take my own life, which unfortunately failed. I’ve seen multiple psychologists, had CBT therapy, other forms of therapy since around that age (basically grew up around the mental health system) which never worked. Started my first antidepressant which was sertaline at 15 years old, came off it after a year as it made me feel sick & did absolutely nothing. Then I got dropped from the child mental health services because of my age so I was left in the dark for a while which obviously worsened my issues. I’m 22 now and have tried every single SSRI, Mirtaziphine, a SNRI, I’m now onto a Tricyclic and tbh I don’t have high hopes for it either as I’ve been on it for 2 months and feel nothing. It’s like my brain is resistant to serotonin, I’ve felt absolutely nothing from any medication or form of therapy I’ve had. I haven’t felt happiness since I was a very small child, I don’t even remember what it feels like. Sometimes I believe my body generally just wants to go as I’d finally be at peace. What really is the point in trying to get better when I know it never will? 13 years I’ve been like this and nothing has ever made me better. The anti depressant I’m on is supposed to be specifically for ocd so why isn’t it working? :( idk anymore
I’m medicated for my adhd/autism but these anti depressants are for severe body dysmorphia and ocd.
Meds I’m on:
Elvanese 70mg
Propananol 40mg
Mirtaziphine 15mg
Clomipramine 125mg
| 8 |
Feeling very good on levomilnacipran
|
Feeling very good on levomilnacipran and I am pretty certain that it is beyond serotonin and norepinephrine. It is because it is NMDA antagonist. I think so because I have experience with memantine.
| 2 |
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