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Have you found that your physical fitness has worsened because of the medicines? What did you do to improve it?
|
I find that I feel very tired and lethargic. I start to run out of breath very easily. I am very heavily medicated. I suspected that it must be because of testosterone count lowered because of the medicines but that isn't the case either. As my testosterone total level is almost 600 ng/mL.
What has been your experience?
| 12 |
Heavy marijuana use increases schizophrenia in men, study finds
| null | 25 |
Lexapro to Effexor
|
Hello! Just wondering if anyone has gone from lexapro to Effexor. If so how did you switch? My doctor wants me to stop 20mg lexapro for 2 days then start Effexor. Is this common?
| 1 |
Sarcosine personal trial for anhedonia and apathy
|
I've been trying it for 5 days, what I can say is that it's not something special, the effect is subtle but it has an action to increase the perception of pleasure in general, but it doesn't last long, 2-4 hours. I am taking 1 gram in the morning and 1 gram in the afternoon. I have no major side effects but its short duration is annoying.
I think I'll finish the box but I don't think I'll buy it again unless it gives me some additional benefit.
I opened a capsule to taste its contents since it was defined as sweet as sugar and I think it is much sweeter than sugar in equal quantities.
As for the NAC, I think I will take 600mg 2-3 times a week as I have read many negative reviews about it.
| 9 |
Should I ask my Dr. for amitriptyline, Clomipramine, wellbrutrin, or Auvelity?
|
Hey guys,
​
So right now I've been tapering down Effexor with the goal to get off of it completely. I've tried effexor, prozac, zoloft, and wellbrutrin. I've been having a very low mood and it's been really really bad lately so I have an appt with my doc today and I'm going to ask him for one of these. Idk which one I should try first. I've tried wellbrutrin before and it did help, but I was still depressed on it, so I would definitely need something else as well. I also have been doing at-home ketamine treatments since late December (oral troches) and I feel like it's helping but I'm just really down now. I'm not sure if it's because I'm tapering off of the effexor or not. So I'm a bit scared to try clomi or amitrptylite but I do need something super strong! I know wellbrutrin has helped before so I'm wondering if Auvelity would help even more. But I'm not sure if the Ketamine is working or not...
Anyways it's hard to keep track of what is causing my low moods but I def need something else that is strong. Any suggestions or experience from someone trying these medications would be great. bTW, I have major depressive disorder, generalized anxiety disorder, ADD, and some intrusive/obsessive thoughts (have not been officially diagnosed with ocd). My depression symptoms are fatigue, hopelessness, lack of motivation, lack of pleasure, bored/uninterested in most things, not excited about the future, easily aggitated/frustrated/irritated, negative thoughts about myself and life in general, not caring about making friends.
I take 20 mg adderall XR in the morning and 10 mg IR in the afternoon.
| 2 |
Fluvoxamine (Luvox) side effects will go away?
|
I was put on fluvoxamine (Luvox) recently. I have to take 50-50-100mg during the day and the 100 is evening.
I feel fatigue, sleepiness, some brain fog, and some extra bowel movement. It is really annoying, but these will go away or not? What was your personal experience?
Other SSRIs did not make me feel sleepy, I had other side effects, like sexual disfunction which I still have on fluvoxamine unfortunately, but I don't wanna be sleepy and feel fatigue forever though.
| 2 |
Do anti-anxiety drugs and anti-depressants work ?
|
Are there any side effects ? Are there any drugs which can be taken without having to consult a psychologist ? (Parents won't let me see a psychologist)
| 12 |
Is armodafinil good who is anxiety prone compare to modafinil ???
| null | 1 |
Has anyone tried TDCS? Transcrainial Direct Current Stimulation
|
Hey guys, wondering if anyone has tried this. People have said it is a mild form of ECT. The devices are on Amazon for only $130. I’m really interested in hearing peoples feedback and experiences!
| 7 |
Does clomipramine lead to anhedonia like a lot of SSRIs do?
|
Hey guys, I’m thinking of trying clomipramine to help with my depression and anxiety/intrusive thoughts. I’m worried it will lead to anhedonia like SSRIs can. Does anyone have thoughts or experiences that they want to share? Thanks!
| 3 |
Mirtazapine 15mg vs 30mg difference?
|
I’ve been on Effexor for ages but doc added in Mirtazapine 15mg to help new depression/anxiety.
Felt a bit of a boost at first from 15mg, now sort of just back to blah.
Does 30mg make you any more sedated?
| 2 |
Depression / situational not depressed before
|
So I have / got a back injury in two places three mo ago. I have been depressed ever since since I can’t do anything really. Still driving but am spacey from the med I’m on which I need to get off of cause it’s awful ( Tramadol)
My pain mgmt Dr is not great. But anyway I’m depressed fairly severe from this as I’m an active person otherwise & very independent .,
What should I do since I have multiple issues . Back pain mgmt , depression and also need to get off this awful tramadol I’m on. Like I need a detox tbh. My husband and I don’t know what to do.
Also what medication do you think they may put me in for depression that’s not from before but from my situation? I am afraid of further meds because of the tramadol mess.
| 2 |
Progress and challenges in research of the mechanisms of anhedonia in major depressive disorder
| null | 17 |
if 150mg of wellbutrin xl didn't do anything in 25 days apart from moderate increase in anxiety should I ask my doctor to up it to 300mg?
|
I am on 200 lustral
2.5 ml abilify
150 mg wellbutrin xl
should I ask my doctor to up wellbutrin to 300 and prescribe me something to manage the anxiety if necessary?
I didn't notice anything from the 150 dose other than moderate increase in anxiety which is probably in part because I didn't feel any improvement even though I have had high hopes for wellbutrin
any one with experience or knowledge, please help
thanks
| 1 |
SI warning
|
I’ve come to the end. I have tried 11 meds and I cannot get relief from depression and anxiety since Zoloft failed.
I’ve tried Zoloft, lexapro, Effexor, Pristiq, Valdoxan, trintellix, dexamphetamine Prozac, Lamictal, moclobemide, Parnate and now I’m given Cymbalta. Haven’t started it
Im also on 150 Seroquel. I just want to die now. I want to end the constant pain and suffering. I’ve tried to climb out but I can’t. I might get 25-30% response to
A medication. I find life so unfulfilling and boring and utterly pointless and useless
Why should I go on?
| 12 |
Anyone here taking either Clomipramine or Abilify?
|
What dose do you take and is it helping? How long did it take to see benefits?
| 3 |
Is it worth it changing meds if you've stabilized from a particularly bad period? Persistent Depressive
|
I'm on a combo of drugs: seroquel + ciprolex. I had a really tough winter and I think part of it was that it's winter, also I was focusing on "curing" my depression and the fact it wasn't getting better and over focusing made me more depressed. I went to see if I could change my medications but now I've stabilized a lot more and I just don't really want to put my body through the ringer to try a different mood stabilizer, which probably won't do much for me when I get in those moods.
I feel like I just need to accept I feel like a general "blahness" about life sometimes that will never really go away. And I just need to accept where I'm at rather than try some new med combo.
Any thoughts?
| 3 |
PSSD for almost 4 years now. What would you do?
|
PSSD is post SSRI sexual dysfunction. I took an SSRI antidepressant short term in 2019 and my life has been ruined ever since. Numb emotions, no libido and no pleasure in orgasms. Pretty much everyone in the r/PSSD forum hasn’t improved and many have had it for over 10 years. It has made me so suicidal and it’s devastating what has happened. What should I do? I’ve tried so many supplements and Wellbutrin. Little to no help
| 5 |
Why dopamine agonists don't work as stimulants?
|
I tried dopamine agonists (Pramipexole and Ropinirole) in the morning and they made me extremely tired at daytime.
My intention was to experience a stimulant effect because of dopamine but I felt the opposite. Any explanation?
| 4 |
In case it helps: I'm currently on Wellbutrin XL 300mg - prev tried Lexapro, Pristiq, Abilify, Rexulti, Zoloft, Pregabalin - dysthymia, MDD, social anxiety disorder, BPD - my energy has been amazing, though there are downsides
|
Hey, I've had depression/anxiety since childhood and I'm mid-late 20s now. I've been on medication for about 8 years? Mixed results. Throughout my treatment, I was comforted and educated a lot by other people's experiences, so I thought I could include my own. I'll talk about my current medication regime now as I also want some other perspectives:
Wellbutrin XL 300mg, taken in the morning. This medication has finally made me have energy!! I had been so tired every day I could take a nap any time in the day, for many years. But the Wellbutrin made me feel.. Human again? I didn't really need or want to take naps anymore, and sometimes I felt a bit hyper/bright again and I have times where I like to be silly and light-hearted. My depression is bettered a lot. However, oh boy, my anxiety is BIG. I don't think it's just because of the Wellbutrin though, because my anxiety was big before. I think after going on Wellbutrin though, I feel the anxiety a lot more emotionally - I cry so often, probably 2 out of 3 days. I also want to cry for silly things, like a heartwarming story or a melancholic song. I don't experience any side effects other than that. All-in-all, Wellbutrin is a good time. Doesn't cure me, but has definitely changed how I feel.
And now chronologically, I was on:
\- Pristiq, I don't remember the dose but I went pretty high - it worked okay for the first few years but it definitely felt like it wasn't doing anything maybe 4 years in. Oh, I also was on Effexor a little bit before that, but I don't remember anything about it or even why I switched to be honest. I think it just took a little bit of weight off my depressive episodes and helped me with motivation. I know a lot of people make the withdrawal from Pristiq sound horrid and I think it is if you go cold turkey because I always KNEW when I missed a dose because I'd feel the buzzing in my head 12hrs past the missed dose. But, I tapered off + replaced it with Wellbutrin so it was actual fairly uneventful.
\- Abilify, I also don't remember the dose. I got onto this on recommendation from my mental health professional friend, because I just couldn't get myself stable enough emotionally to make any progress in my therapy. I remember this really helped - my moods fluctuated a lot before this (err, well never in a positive way, just like, from kinda-sad to ahhhhh-gjafisjf-i-hate-everything-sad) and after it's like I didn't get \*as\* sad. Or more like, even if I did get really sad, it didn't control me as much. HOWEVER!!! This was when my weight gain started. I was quite thin before this - due to lack of motivation/desire for self-care + self-punishment, I did not eat very well. After this medication I was able to eat better but I slowly gained pound after pound and could not lose it. After a while, I did switch to:
\- Rexulti, in an effort to curb the weight gain. It didn't seem to do anything with that, though maybe it slowed it down? I did still gain a few pounds, it's just hard to say if the weight gain plateau'd or not. I also have PCOS but so far my bloodwork indicates that shouldn't affect me much. This was basically the same as the Abilify I guess. I got off of it when I got on the Wellbutrin. I did once go off of it without replacing it with anything (I thought I was doing well so it would be okay! But it turns out repressing past trauma is not the way to 'do well'), and it was a horrible horrible time because I had many a mental breakdown. Haha.
\- Pregabalin, I went on this a bit after I stopped the Rexulti, I don't really remember why but we were trying to see if it would help my social anxiety. My psychiatrist said there are unfortunately few medications that work with SAD but this could. It didn't though lol. I tried for several months, went on a pretty high dose, then just went off of it and felt the same.
\- Zoloft, to be honest I don't think this did anything. OH EXCEPT, my dreams became insane. I was already a vivid dreamer, and after I started Zoloft it was like every night's dream was a fever dream. I wouldn't mind that in itself, but it did affect my sleep quality and made it really hard to snap out of my sleep-state. I slept in a lot. I've been off of it for 3-4 weeks now actually, and I still feel that side effect. I'm hoping it goes away ASAP. I think it's getting better though.
I know I wrote a lot and I don't know if it will help anyone but I hope it does! At least it helps me self-reflect. There is a lot I didn't write here too. I think my experience with medication has been okay as I never had any terrible side effects other than the weight gain. Been fortunate in that regard I suppose?
​
Side note: Has anyone tried rTMS?? I live somewhere that could cover it with public funding or something (or maybe 'cause I'd be used for a study, IDK lol). However I'd have to go in 5 days a week for several weeks, which sounds. Crazy. But if it's really that amazing then I'd do it.
| 10 |
clomipramine and side effects
|
Hello!
i been eating clomipramine for ocd and depression for years. Right now i am on 100mg. Recently tried to raise the does to 150mg but the side effects i get was unmanageable, so I had to go back to 100mg
I wonder if someone have managed eating a lower dose on clomipramine or other meds affecting the serotonin? have any tips?
| 1 |
Why don't dopamine injections cause intense pleasure?
| null | 1 |
I feel great. 4 months of no meds. Thank you all.
|
Spanish first, then English.
Translated by DeepL.
\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*
**Estoy realmente bien**
Escribo rápido porque tengo muchas cosas que hacer y disfrutar y estoy a tope.
Estoy a **0mg de Abilify, 0mg de Cymbalta.** Algún Orfidal ocasional, lorazepam, cuando llevo algún día que otro sin dormir. Tengo mucha energía ahora mismo.
Este viernes tuve cita con mi psiquiatra, y también con mi psicólogo habitual. Sólamente para manejar tanta energía que ahora tengo.
Llevo actualmente 4 meses a 0mg de Abilify y 3 meses y medio a 0mg de Cymbalta. De momento estoy muy bien, y espero estarlo en el futuro. Cruzo los dedos.
Pero ambos coinciden en que estoy bien. No estoy hipomaníaco y en general mi vida a mejorado: hago mucho más deporte, estoy comiendo mejor y bebo mucho menos alcohol que antes.
He recuperado mi afición con la música, apenas paso tiempo en el ordenador fuera del trabajo (no me disgustan los videojuegos, pero ahora tengo tan poco tiempo que prefiero dedicarlo a cosas que disfruto más). Además me he apuntado a clases de bailes latinos y también a un gimnasio al que, de momento, sigo yendo.
**Claves de mi recuperación:**
\- **Aceptar mi ira, mi agresividad** y momentos de cabreo: no he agredido a nadie ni faltado a nadie al respecto, quizá haya hecho alguna broma o comentario jocoso que ha podido herir a alguien pero nada serio. Pero ahora defiendo mis derechos, creo que simplemente durante la depresión he dejado que me pisen, ahora simplemente creo estar más en mi sitio.
\- **Permitirme disfrutar** de la vida: nuestros familiares y amigos que nos quieren quieren que disfrutemos.
\- **Preocuparme menos:** me olvido continuamente las cosas y en mi trabajo al veces me olvido de detalles. Pero no importa, el no preocuparme hace que tenga mucha energía y con eso estoy rindiendo más y mejor. Los errores de mi trabajo son solucionables y la mayoría no tienen una especial implicación, de mi trabajo no depende la vida de nadie y, aunque dependiera, trato de hacer lo mejor y cometo errores: soy humano y esos errores me sirven para seguir aprendiendo. Estoy contento laboralmente.
Es increíble como te sorprendes a ti mismo cuando te das cuenta de que preocuparse no evita la mayor parte de los males y, desde luego, no sale rentable tanta preocupación. Cuando no legitimas el estar preocupado, ganas muchísima energía.
Un ejemplo fácil: este texto no está revisado una y otra vez. Lo escribo, lo traduce DeepL y ya está, no el doy más vueltas. Copiar y pegar y ya, no 50 revisiones.
\- **No sobrepasarme y llevarme bien con todos en lo que pueda: es imposible caer bien a todo el mundo.** Pero trato de pasar más tiempo con quien me llena de energía, incluso en familiares muy cercanos he tenido que cambiar mi interacción y no implicarme tanto, ya que no llevan bien mi personalidad actual.
Con aquellas personas que no me llevo bien, trato de tener un trato cordial y alejarme lo más rápido posible. Si estoy obligado a tener trato, intento tocar temas que nos diviertan y disfrutemos.
**With those people I don't get along with, I try to be cordial** and get away as quickly as possible. If I am obliged to deal with them, I try to touch on topics that we enjoy and have fun with.
\- **Me acepto a mi mismo:** me ha costado mucho aceptar que, si bien adoro y **quiero a mis sobrinos pequeños, no aguanto más de dos o tres horas con ellos jugando** y estando pendiente de ellos. Al menos actualmente acepto no sentirme culpable ni por no estar con ellos tanto tiempo ni por no tener hijos.
Creo que además les transmito una importante lección: es mejor estar poco tiempo y transmitir mi bienestar, que estar más tiempo y transmitir mi desasosiego o ansiedad.
\- **Trato en la medida de lo posible cumplir con deseos de estar cómodo en cualquier sitio:** hace unos días tenía unas reuniones de trabajo y yo soy realmente inquieto. Me levantaba de vez en cuando de la silla y escuchaba de pie. Salía de vez en cuando a fumar (asignatura pendiente el dejarlo)... y nadie me lo reprochó.
\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*
English:
**I am really well**
I'm writing fast because I have a lot of things to do and enjoy and I'm in full swing.
**I'm at 0mg of Abilify, 0mg of Cymbalta.** The occasional Orfidal, lorazepam, when I've been sleepless for a day or two. I have a lot of energy right now.
**This Friday I had an appointment with my psychiatrist,** and also my regular psychologist. Just to manage so much energy that I have now.
**But they both agree that I'm fine. I am not hypomanic** and in general my life has improved: I do a lot more sports, I am eating better and I drink a lot less alcohol than before.
I am currently 4 months on 0mg Abilify and 3 1/2 months on 0mg Cymbalta. I am doing very well so far, and hope to be in the future. Fingers crossed.
**I have regained my love of music,** I hardly spend time on the computer outside of work (I don't dislike video games, but now I have so little time that I prefer to spend it on things I enjoy more). I've also signed up for Latin dance classes and also a gym which, for the time being, I'm still going to.
**Keys to my recovery:**
\- **Accepting my anger, my aggressiveness** and moments of pissed off: I have not assaulted anyone or disrespected anyone about it, maybe I have made some joke or jocular comment that could have hurt someone but nothing serious. But now I defend my rights, I think that during the depression I simply let them step on me, now I just think I am more in my place.
**- Allowing myself to enjoy life:** our family and friends who love us want us to enjoy ourselves.
\- **Worry less:** I keep forgetting things and in my work I sometimes forget details. But it doesn't matter, not worrying makes me have a lot of energy and with that I am performing better and better. The mistakes in my work are solvable and most of them do not have a special implication, nobody's life depends on my work and, even if it did, I try to do my best and I make mistakes: I am human and those mistakes help me to keep learning. I am happy at work.
It's amazing how you surprise yourself when you realize that worrying doesn't prevent most ills, and it certainly doesn't pay to worry. When you don't legitimize worrying, you gain a lot of energy.
**An easy example: this text is not revised over and over again. I write it, translate it DeepL and that's it, I don't give it any more thought.**
Copy and paste and that's it, not 50 revisions.
\- **Not to go overboard and to get along with everyone as much as I can: it is impossible for everyone to like me.** But I try to spend more time with those who fill me with energy, even with very close relatives I have had to change my interaction and not get so involved, as they don't take my current personality well.
With those I don't get along with, I simply try to stay away as much as possible and, in case I am obliged to, try to have a cordial relationship and avoid controversy. Argue only when there are no other options to maintain my well-being. Not to waste bullets when the battle is not worth my energy.
\- **I accept myself:** it has been hard for me to accept that, although **I love and adore my little nephews and nieces, I can't last more than two or three hours with them playing** and being aware of them. At least now I accept that I don't feel guilty for not being with them so much or for not having children.
I believe that I also transmit them an important lesson: it is better to spend a short time with them and transmit my well-being, than to spend more time with them and transmit my uneasiness or anxiety.
\- **I try as much as possible to fulfill my desire to be comfortable in any place:** a few days ago I had some work meetings and I am really restless. I got up from time to time from my chair and listened standing up. I went out from time to time to smoke (I had to quit smoking)... and nobody reproached me for it.
Translated with www.DeepL.com/Translator (free version)
| 9 |
What is the price for Esketamine prescription in UK?
|
There have been so many times in the past where I've felt tempted to buy ketamine from the deep web due to all the studies saying it can really work for treatment-resistant depression. But I don't exactly wish to risk up to 5 years in prison, an unlimited fine, and a permanent criminal record. Until recently this risk didn't bother me, as I felt I truly had nothing left to lose. But now I've reached a point in my life where I have quite a lot to lose. I'm not willing to take the risk.
Fortunately, it seems recently a nasal spray version of Ketamine called "Esketamine" has been approved for treatment-depression in UK. I've been advised it is expensive though.
I don't care about price, but for the record, how much is say a month's worth in UK?
| 3 |
Posted numerous comments about various treatment options in the other thread. Probably someone might find them useful.
|
If you are curious, please follow this link:
[https://www.reddit.com/r/depressionregimens/comments/12hlzwc/comment/jfsbrt6/?utm\_source=share&utm\_medium=web2x&context=3](https://www.reddit.com/r/depressionregimens/comments/12hlzwc/comment/jfsbrt6/?utm_source=share&utm_medium=web2x&context=3)
| 3 |
Vilazadone
|
Hey guys! I have tried many anti-depressants in my lifetime. I just recently started one about four to 5 weeks ago. At that same time I had a lot going on in my life. A lot of high stress. Fast forward. Things have calm down in my life. But I missed a dose of 20 mg of Vilazadone on Thursday morning. Took it again Friday night when I remembered. Friday I take a nap at 4 PM and don’t wake up till about 7 PM. I usually take long naps, but this was different. I physically could not get myself up. I tried even trying to sit up in bed. And I would just fall over and go back to sleep. Nothing I did would keep me awake. It wasn’t until my dog laid on top of me that I actually got up. I was just so tired even after that that I went to bed pretty early. Needless to say my sleeping since then has been pretty heavy. I keep feeling like I need to nap or hit snooze. Like last night for instance, I got solidly eight hours of sleep, but I desperately wanna go back to bed. But here’s what I started to notice and was starting to freak me out a little bit. I don’t know if it’s because I spent so much of my weekend dreaming but I’m having a hard time differentiating things. Like I have intrusive thoughts, but there’s a part of me that’s like we’re still asleep? I know that consciously I do know that I am very much awake. But I feel like I’m wandering around in this weird twilight zone. I genuinely feel crazy. I feel like I can’t connect to anyone. Like I’m lost in my own little world. Hell I just started crying in 711 for no reason. This is not how I normally am.. I even feel like I have a hard time finishing sentences at work. I feel so out of it. Any thoughts theories suggestions? Is there some MH disorder you can get in your 30s?
| 1 |
Beating MDD
|
Is it possible to beat major depressive disorder without drugs? I haven’t had much success and the one that seemed to really help has caused too many side effects.
| 9 |
I am taking trintellix + rexulti + lamictal for MDD, GAD and PTSD/instrusive thoughts
|
40M
recovering alcoholic, havent had a drink in almost 6 months
i tried pristiq, zoloft and now trintellix 15mg (been tapering up for 1,5 months, 9 days on this dose)
started 0.5 rexulti yesterday, in 5 days will go to 1mg
am on 100mg lamictal (doc wants 200mg)
I am still having the worst anxiety I've ever had and crazy intrusive thoughts. and depression.
what can you say about this mix?
| 9 |
Are there any meds specifically for mixed anxiety and depression disorder?
|
I know that anxiety and depression both tend to be treated nowadays with SSRIs as the first option and that there are some drugs which are really only good for depression (e.g. Wellbutrin) and others that are mostly only of benefit to anxiety (eg Pregalbin).
Are there any meds, however, that were specifically intended to alleviate both depression and anxiety for patients with this common dual diagnosis?
| 18 |
My meds really help my depression but make my anxiety worse, especially quetiapine, any idea why?
|
I’m on 120mg Duloxetine, 350mg Quetiapine, 200mg Lamotrigine. I’ve recently started gabapentin for my restless legs syndrome, and bizarrely that helps my anxiety when I take it at night.
| 5 |
Final answer plz .is Armadofinil smoother than modafinil in terms of anxiety ?
|
[View Poll](https://www.reddit.com/poll/132t3cy)
| 0 |
Stimulants and mood swings
|
Decades ago I tried Adderall and felt great for the first couple of days. Time didn’t drag, motivation, etc.. But then the dark days would come in and I experience real cycling. Added abilify and I just felt agitated and worse. I actually ended up in the hospital.
Much later I tried Ritalin. It sparked occasional weird annoying brain wave sensations. I was also on Lamictal.
I’m not regularly bipolar but obviously I am at risk. Mood stabilizers have all caused my mood to worsen or induce increased agitation.
I take Modafinil for chronic fatigue. I’ve noticed magnesium has made that smoother for me.
Over the years I have tried everything- including ECT, TMS, ketamine, low dose psilocybin, supplements.
I don’t drink anymore (the depression hangover isn’t worth it for me)- but that seems to be the only time where my mood is elevated and time passing isn’t like nails on a chalkboard. I also have crazy inner restlessness. Kind of ADHD-ish but able to focus.
I am on a handful of meds that I won’t mess with because withdrawals of anything make my mood worse.
I’m sick of being miserable and forcing myself to do everything. I find nothing enjoyable of of course there is no motivation.
Any ideas?
| 1 |
Whats your experience of Cymbalta for Seasonal affective disorder?
|
Whats your experience of Cymbalta for Seasonal affective disorder?
| 3 |
My anxiety/depression blanks my mind and doesn’t give me confidence or a reason to do anything or gives me clear ideas for anything to do in my day to day life. For anyone who went through that themselves, what can I do to feel better when I carry these feelings everywhere?
|
I carry them when I socialize so it can make me quiet, I carry them when I exercise, look for jobs (makes me doubt I can do a good job so I don’t move past the onboarding process, etc) I’m in essence stuck and am looking at medical Marijuana as a option in capsule form and got my id for it. I feel like a rewriting of my brains thinking patterns is needed at this point and it’s hard to do it on my own
| 20 |
Agmatine
|
I've been trying it for a few days initially at 1 gram a day even though yesterday was the third day and I took a second gram in the evening and today which is the fourth day I just took 2 grams. But I won't do it again, I did it because I have a belief that if you don't feel completely comfortable with something and you take a double dose then the initial dose won't bother you anymore.
I expected an immediate antidepressant effect, some talk about it as a ketamine with no recreational effects. All I've experienced so far is a feeling of dissociation the first 3-4 hours after taking it.
Being considered a fast-acting antidepressant supplement, I guess if I haven't noticed great results so far there's no point in continuing to take it.
| 1 |
Combo doubt !
|
Is clomipramine ( low dose ) and mirtazapine combo similar to venlafaxine and mirtazapine one ?
Regards
| 2 |
Your experiences with Fluvoxamine? Also known as Luvox
|
I've tried several medication to lessen the severity of my mood swings and anger, so far none of them really helped and also as a male made me affect sexually as a side effect.
my simple question is, do you have any experiences with Fluvoxamine? Also known as Luvox.
Most SSRIs helped a bit with my anger but it's really hard with everything
Im not only looking for experiences from people with BPD, bipolar, or OCD, but mostly depression as well.
| 8 |
What medication for depression and anxiety has the least side effects and works really well for both in terms of getting your zest for life back
|
I am on cymbalta, was on lexapro and Wellbutrin and have taken olanzapine for a bit now. I’m wondering what medication will help me get my zest for life back when I can’t get my mind to think positive
| 5 |
Is there anyone on Vyanase that takes Mucuna Pruriens to avoid the 'crash' that hits after about 7 hours?
|
If so, can you please tell me what dose of MP and your response?
| 3 |
Recently got prescribed Auvelity but I'm not sure if I shouldn't wait to actually take it
|
I was recently prescribed Auvelity but I'm debating waiting a little bit to take it. I have a concert two weeks from now and it's a band that hasn't toured the US in 8 years and I'm concerned about being miserable if I experience side effects. Especially tiredness as I'm already exhausted. It would be great if I was less depressed and had more energy for this concert but I'm not sure it's worth the rest. So my questions are how long do the side effects typically last? And if you stop taking it how long before they go away? Obviously I'm going to ask my doctor and pharmacist but it's pretty new so I'm not sure they'll know so I figured it doesn't hurt to ask here too.
| 2 |
Mega dose omega 3 ?
|
Hi all,
I read somewhere online that people take upwards of 18 caps of fishoil/omega 3 a day to help depression.
I tried it yesterday and I did get some stomache pain.
However, it is recommended to get high dose EPA. My question is, did it help anyone here ? How much do you take ? And maybe also, is there a specific type of fishoil/omega 3 that might have a higher level m of EPA so I dont have to drown myself in fishoil to get enough EPA.
Thanks
| 5 |
Lexapro with American Ginseng?
| null | 1 |
What helps with that empty head feeling or when your thoughts feel really really slow?
| null | 4 |
Does anyone else use dopamine from anger to get started doing anything?
|
As per title: Does anyone else use dopamine from anger to get started doing anything?
I have a highly specific example but I suspect it applies across other anger inducement methods as well
For me, I tend to get mad in competitive pvp games when I lose or in the case of unexpected outcomes where I underperform with respect to my own expectations.
For whatever mind boggling reason this triggers some bizarre spark of motivation in myself that awakens me from my regular low-dopamine depression stupor.
In other words, I need to feel fury to be able to bring myself to care.
Does anyone else use anger to start their figurative engines? Does this regimen have a clinical or scientific name to it?
| 3 |
Problems with 'pruning' brain connections linked to adolescent mental health disorders
|
[https://www.sciencedaily.com/releases/2023/04/230424133602.htm](https://www.sciencedaily.com/releases/2023/04/230424133602.htm)
Interesting read and update.
**GPT-4 TLDR:** Adolescent mental health disorders may be connected to issues with the brain's ability to "prune" unnecessary connections, according to an international study. This discovery could help explain why individuals often suffer from multiple mental health disorders and may aid in identifying those at greater risk. One in seven adolescents experiences mental health disorders, such as depression, anxiety, and ADHD, which can manifest as internalizing or externalizing symptoms.
Researchers identified a pattern of brain activity, called the "neuropsychopathological factor" (NP factor), among adolescents experiencing mental health problems. The NP factor was mainly found in the frontal lobes, responsible for executive functions such as flexible thinking, self-control, and emotional behavior.
The study examined data from 1,750 adolescents in the IMAGEN cohort and replicated its findings in 1,799 participants from the ABCD Study in the USA. The NP factor was found to be stronger in individuals with a specific variant of the IGSF11 gene, previously associated with multiple mental health disorders. This gene plays a crucial role in synaptic pruning, a process where unnecessary brain connections are discarded. Disruptions in this pruning process could impact communication between brain regions, particularly affecting the frontal lobes.
The discovery of the NP factor could help identify young people at higher risk of mental health problems, providing more opportunities for early intervention and risk reduction.
​
**GPT-4 Extra TLDR:** Research suggests that problems with the brain's ability to "prune" unnecessary connections may contribute to adolescent mental health disorders. This finding could help explain why people often experience multiple mental health issues and assist in identifying those at higher risk, potentially enabling earlier intervention.
| 11 |
Rexulti Dosing Time?
|
My doctor just prescribed 1mg Rexulti as an adjunct to Wellbutrin and Lexapro for treatment-resistant depression. He told me to take it at night because it might make me drowsy. Maybe this is a dumb question (and I probably should have asked), but will I be sleeping on the effects? Just want to make sure I’m getting the most out of it.
| 1 |
Asking docs for more than the FDA max of an SSRI?
|
I've always felt that I could benefit from taking perhaps just a little more than the official "limit" for various SSRIs (eg 20mg with Lexapro).... and I know that there are folks - especially with OCD - who indeed do better at these dosages (for Lexapro, I've heard of people taking all the way up to 40mg off label).
My question is whether anyone has proactively asked their doc for one of these "supra therapeutic" dosages because you also suspected it might give additive benefit?
If so how did the conversation go? I'm afraid to ask because I assume I'll get shot down and thought of as a difficult patient!
| 1 |
How to lower the antihistaminergic property of antipsychotics?
|
I hear betahistine is a good way to counter that property.
| 1 |
Any good supplement or medicine that goes well with olanzapine?
|
Is there any medicine or supplement that is usually used along with olanzapine as they make a good combination?
| 1 |
Mirtazapine or Antipsychotic?
|
Hi folks.
I’ve just been diagnosed with complex PTSD and Borderline personality disorder.
I have been given the option of mirtazapen or a low dose antipsychotic.
I’m also on 20mg of Lexapro.
Any thoughts/ experiences with these compounds?
Thanks
| 1 |
What supplements have worked for you?
|
I have pretty bad anxiety and now most recently, depression. I’ve tried GABA (stopped bc it was making my low moods worse) and then my ND put me on 5-HTP. I’ve been on that 10 days now and I’m the most depressed I’ve ever been so I’m thinking I need to stop. I’ve been reading things about L-Tryptophan or L-Theanine. Just wondering what natural supplements have worked best for folks here?
| 9 |
I'm wondering if there's actually medication that does more of the work for you?
|
Is there any medication for treatment resistant depression that does more of the work for you when you are unable to do more of the work on your own terms to feel better after trying for so long?
| 16 |
Prozac vs Wellbutrin?
|
Hello. I was given Prozac for binge eating disorder and anxiety/overly emotional. It was causing me to not be able to reach orgasm. Which was frustrating. So my doc switched me to Wellbutrin a week ago. I am able to orgasm again but oh my god. I am so angry. I am being SO mean and saying irreversible things to loved ones. I feel like I’m going crazy. And both the Prozac and the Wellbutrin are a very low dose. What should I do? Stay on Wellbutrin and see if the anger goes away? Or get back on Prozac and deal with never being able to achieve orgasm? I honestly just need something that stabilizes my mood and makes me less emotional. But I can’t deal with weight gain or sexual dysfunction.
| 2 |
About Suicide (and Murder)
|
No one Truly wants death, becauSe Death don't exist ontologically. People want peace, and they think through killing someone (theirselves) they Will be capable of stoping their Pain. Death is an illusion. Suicide is an Illusion.
In my POV, We need to prevent suicide, by helping ALL of those who are struggling.
We need to treat them First. And really really heal his Depression, Anxiety and other disorders. If after that, the waiter wants death anyway, let them do Legal Euthanasia(which is improbable). Because Then It Will be a choice, Depression and Anxiety are both a fog on the brain, and both two needs Therapy(psychoterapy) and Drugs(medicine). And they need to be treatened on the spiritual side too, even If It seems to be "Placebo Effect" or "Confirmatory bias", Spiritual side Matters.
You Can DM me if you need to, I'm always open-hearted
| 0 |
success stories on a higher dose of amitriptyline?
|
i’ve been on 75mg of amitriptyline for two and a half years now and it’s been pretty good but after a recent depressive anxious episode i’ve been upped to 100mg and am starting tomorrow. i trialed nearly every antidepressant and type of antidepressant and tricyclics are the only ones that help! it’s actually that way in all the women in my family lol. we’re all on amitriptyline cause it’s the only thing we respond to. but that being said i am nervous about going to 100mg. my psychiatrist said i probably won’t notice any big side effects since my mind and body is so used to the medication but i love to worry about things i probably shouldn’t worry about. i wanted to know if anyone has any good experiences with the higher more therapeutic dosages of amitriptyline :) thanks!
| 2 |
Do antidepressants (specifically clomipramine) increase risk of dementia or alzheimers?
|
https://www.nature.com/articles/s41598-019-40887-x
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079596/
---------------
I'm wondering if clomipramine may increase the risk? I haven't read the articles because I'm a lazy pos, there are probably some severe constraints on those studies (mice, control groups, whatnot). Not to mention that living with untreated depression is simply worse.
| 6 |
Are there any psychiatric medications that work on dopamine only?
|
I know that reducing mental health to specific neurotransmitters tends to be a gross simplification (and my level of knowledge is very basic), but I thought I would ask anyway.
There are obviously lots of drugs working on the serotonin system in various ways (reuptake inhibition, agonism of specific receptors).
For norepinephrine, there are some well-known norepinephrine enhancing agents like Strattera (NRI) and Wellbutrin (NDRI). There are also of course SNRIs, synergizing the effects of norepinephrine and seretonin.
It doesn't seem, however, like there's any such thing as a (pure) dopamine reuptake inhibitor (DRI) on the market .. at least ones that are used in the treatment of mental health and not neurological diseases like Parkinson's.
Is there a reason for this ... why pure dopamine agonism doesn't seem to have been a target for drug development in depression and other psychiatric conditions?
I know that dopamine gets converted into NE so perhaps one can't be increased without the other?
If anyone understands the neuroscience, I'd be very curious to know some more details.
| 9 |
When can you tell you are addicted to alcohol?
|
Lately I've been drinking two glasses of 12% or 14% red wine for lunch and two-three for dinner. In total 30 cl at lunch and 30 or 45 at dinner. It's not a huge amount but as I get close to the time I'm used to drinking I start to feel a very strong tension and need to. There have been times when I drank more but concentrated over the weekend, but now I'm doing it moderately but constantly.
| 6 |
Trying to find an alternative to benzodiazepines that actually works
|
Nothing has been working for me in terms of dissociation, I think I can make progress in therapy in terms of anxiety and agitation, but dissociation hasn't been getting better for years, DPDR has been a consistent issue for me the only medication that has helped is clonazepam, I haven't had any issues with it and have used it for a while now but I'd much rather not use something that has such a high potential for tolerance issues. Side note, what's a safer benzo? I know certainly some of them such as alprazolam in my experience have more issues than others, so knowing if there's a safer one than clonazepam would be helpful, I know of the risks of benzos.
​
I've tried valproate to try and find something that might help with dissociation, and it hasn't helped, I'm planning on tapering off it soon, so I''ll be on no psych meds and hopefully have a clean slate. In general for depression, schizoaffective disorder, OCD and anxiety, I've tried lexapro, luvox, pristiq, zoloft, mirtazepine, valdoxan, abilify, rexulti, seroquel, risperidal, clozapine, invega, gabapentin, lyrica, and numerous benzodiazepines. They all didn't help and usually made things worse besides maybe gabapentin, lyrica, and benzodiazepines, but I've been very concerned about their long term side effects. Does anyone have any suggestions? I'm considering lamotrigine in hopes that it'll help with my dissociation and DPDR, as well as mood stabilization and anxiety, and clomipramine for OCD, depression, and anxiety, but anticholinergic medications are something I really want to avoid, but at this point I don't know if I'm going to live long enough for it to matter and my quality of life is terrible and my mental health issues have completely debilitated me.
| 14 |
Getting off of SSRIs
|
I am attempting to get off of 100 mg of Luvox on my own by taking 4 more tiny XR pellets out of the capsule each week. I just started this last night, and I still notice some side effects (although they are slight). I am doing this because I know my condition has become increasingly worse since starting the medication in July. I want to tell my psychiatrist, but I worry that it will become like when I was getting off of clonazepam and I wasn't able to go at my own pace, and she'd probably just jump me down to 50 mg or something or by some other recommended titration that doesn't suite me. I've heard some people say they get off of it or at least decrease doses pretty easily, others it seems impossible.
Does anyone have any tips for the process? How long does it take to adjust to dose decreases? Is there anything that helps?
| 4 |
Do MAOIs and TCAs have an indirect impact on glutamate and gaba?
|
I have seen other posts saying that SSRIs can indirectly impact gaba and glutamate - essentially, they inhibit serotonin, which has a downstream impact on glutamate and gaba.
Could the same be said for MAOIs and TCAs?
| 4 |
Coming off meds?
|
I got so anxious watching this. Being on meds for way too many years and I'm worried. What are your thoughts? [https://youtu.be/J66WzcITH9g](https://youtu.be/J66WzcITH9g)
| 1 |
Does the weight gain/cravings associated with Mirtazapine get worse the higher dose (30 and up) you take or is it the same across all dosages?
|
I'm on 15mg right now and I definitely eat a lot more. While I don't mind the weight gain because I'm underweight, I want to know if the cravings get worse if I go a dose higher? My doc did mention me going up in dosage at some point in the future.
| 1 |
Is therapy completely useless for biological anhedonia/depression?
|
Changing thoughts is not going to miraculously get rid of and cure the condition, so why is therapy even a treatment? It doesn’t actually work for symptom relief. Doesn’t actually change hedonic tone and emotionality.
| 29 |
Anyone feel like a different person after going off antipsychotics?
|
I'm not sure where to post this honestly.
I have been on antipsychotics constantly since I was 18, I'm 24 now. Not all the ones I've been prescribed made me a noticeably different person, but they did have the effect of stabilizing my mood.
The last one I was put on helped me successfully recover from a suicide attempt. I didn't notice in the beginning that it made me feel unlike myself. I just noticed that I was less prone to depression and impulsive behaviour. However, I started noticing more and more that at my new job, I couldn't assimilate into the casual atmosphere. I noticed I was overly uptight in the beginning, but I realized more and more that my constant seriousness and humourlessness was making it impossible to make friends. I never laughed because I was amused- I laughed because I knew something was funny in theory, or because everyone else was laughing. I started googling things like "how to be funny" which was strange, because throughout my life I had always been seen as a funny person with a spontaneous and wacky wit. I realized that unless the pandemic, or getting older, truly changed my core personality, my antipsychotic must be doing it to me. I also suspected that it was taking away "my spark" although I wasn't sure what I meant by that, it was a gut feeling.
Now this drug is fully out of my system and holy shit do I feel different. As soon as I started genuinely being amused again, I began being silly. I felt lighthearted and relaxed at work rather than overly serious. My coworkers immediately sensed the difference and began talking to me differently. Quite unexpectedly, I started winning at team games I had previously been abysmal at, presumably because I was thinking more clearly and quickly.
I feel flirtatious, light hearted, emotional, and impulsive. For better or worse. Something bad happened at work somewhat recently and I had been stuck in this state of alternating between rage and paranoia- suddenly, feeling more light hearted, my emotions shift away from that and I actually feel LESS angry. I was afraid I'd feel more angry but actually my emotions changing more quickly and feeling light hearted and humorous breaks me out of the rage.
I think there is a chance this will get old, I'll start engaging in bad behaviors again, or otherwise experience the problems that made me end up on antipsychotics in the first place. But for now it's such a relief to have a sense of humour and feel joy rather than mere contentedness. It's allowing me to fit in better at work at the very least.
The biggest downside so far is mood swings where I feel suddenly empty inside and pointless. I used to go to great lengths to self medicate that, but for now, it's not all the time and I can just ride it out. I also feel excessively lazy but I'm suspecting that it's an effect of withdrawal as I'm also struggling with sleep and nausea. I'm hoping that in a few days my sleep will begin to normalize, I'll have more of an appetite, and maybe I'll feel even more motivated than before not being bogged down by a sedating dopamine antagonist! I can only hope.
Any similar experiences?
| 2 |
Medication to get me through a hard time?
|
Hello. I am currently going through some really sudden hard times. My long term partner and I are ending things and Iv not been able to handle it well. I currently take Wellbutrin and vyvanse for mental health. And iv been through breakups before. But this time is different. I haven’t eaten in 3 days. I can barely force myself to drink water or shower. I can’t function at work. I was sent home at work for having mental breakdowns. I can’t get through the day and night time is even worse. Iv slept 6 hours total in the past 3 days. My anxiety is so high, my head is spinning and I just can’t function. I feel like I should be in a mental ward. I have a dr apt on Monday and I was thinking about asking for something to help me get through this but idk what to ask for. I just need to stop feeling and thinking so much. I need to get some sleep. I need to not care. I need to unwind. I need to relax. Idk where else to turn. I am in therapy as well but it’s not doing anything for my brain. Anyone have any suggestions?
| 14 |
Need Advice Regarding The Dosage of Wellbutrin/Bupropion
|
hi there,
To those of you who take 300mg of Wellbutrin; Do you take 300mg Wellbutrin/Bupropion all at once or split into 2 doses of 150mg.
Thanks in advance
| 1 |
does lions mane cause hair loss?
|
?
| 1 |
What’s good for intense depression, anxiety, and emotional dysregulation that leads to anger issues, etc
| null | 16 |
Low dose aripiprazole with low dose amisulpride
|
Have some leftover aripiprazole and remember making it me too restless and jittery so was changed to low dose Amisulpride.
Don’t notice nothing from Amisulpride so was thinking of experimenting with a combination with abilify.
Would Amisulprides binding affinity of the presynaptic dopamine receptors be stronger than abilify’s agonization of these presynaptic receptors? Would think they should synergize but I dunno
I will update some days later if this combination is any good of not
| 1 |
I thought my depression was more situational, but now am wondering if I should just up my meds
|
A lot of my depression stems from loneliness. I want to be held so badly. Damn, it's been so long and it's just like this sad hunger and it's really hard. And just as much as I miss having an SO, I miss having a solid group of friends just as much. At 41, most people my age are either married or have kids or both, and are hanging out with people who are in the same boat. I've got a handful of friends, and I'm grateful, but I don't have a robust social life and I long for that.
Or...I thought I did. Is that what I want or do I just want better brain chemistry? I was making myself go out twice a week to do somethng social and it was helping, but lately I'm so physically fatigued and anhedonic that I don't feel like answering the phone and absolutely dread the idea of going out and getting to know strangers because it sounds like pushing a boulder up a mountain. It's beyond the normal nervousness of meeting people. I feel physically sluggish to the point where I'm moving as though I were sick.
I feel like I'm sinking. Tomorrow I'm going to get back into therapy, make an appointment. That really did seem to be helping, but I quit because I hit a plateau. I thought I got enough tips from my therapist to go it alone, but I feel like I'm barely holding it up. And I'm wondering if I should call my psychiatrist too. I hesitate to up my meds if this is more of a situational problem.
I don't know. Brain fog makes decisions hard.
| 6 |
Can you get withdrawals from Pregabalin 300-400 mg every 3-4 days
|
This is the dose I have been taking basically since December. I take it for emotional blunting. I also get afterglows from it on the next day.
I was doing much better recently but in the past week have had a sudden worsening in symptoms. It did not come on gradually. But it happened 2 days after Lyrica last week on Sunday 4/16. Then I did it again last Monday. And my symptoms got even worse on Wednesday 4/19. On Friday 4/21 I ended up taking it again, had a one day afterglow that was better, and now today I am feeling really bad
I feel pretty anhedonic now while my anhedonia before was just mild and my main issue was blunting. Now its hard to get through the day even.
Is it possible to get withdrawals at this dose and frequency? Keep in mind I am extremely sensitive to drugs.
| 5 |
To Those who Are Struggling with Depression/Anxiety
| null | 0 |
Fluoxetine, paroxetine or escitalopram for GAD???…
|
My GAD causes severe anxiety at times and I am wondering what would help me best….. I’ve been on escitalopram before but this time they gave me fluoxetine, will this be a good option for me? I am supposed to increase dose tomorrow…. Started on 10, supposed to start taking tomorrow 20 mg but I’m nervous cause my insomnia just seems to start getting better and I don’t want to feel like I am unable to sleep again…
Doctor said that is fluoxetine doesn’t work we can change to paroxetine but I honestly don’t know what else to do anymore… trintellix nearly killed me and I’m just terrified to felt like that medication made me feel ever again.
| 3 |
Is there an evidence-based/trustworthy probiotic product to reduce anxiety?
|
Hey everyone --- dealing with a lot of anxiety, and I'm hesitant to try SSRIs because I'm really scared of sexual side effects.
I'm considering trying a probiotic, because it seems like a low-risk way to possibly attenuate some of my anxiety. Is there a gold standard product? There seem to be many probiotics that claim to reduce anxiety/improve mood, but it's hard to tell which are reliable.
I'm currently interested in this one: [https://www.amazon.com/InnovixLabs-Lactobacillus-Rosell-52ND-Bifidobacterium-Rosell-175/dp/B00ZMO7UKW](https://www.amazon.com/InnovixLabs-Lactobacillus-Rosell-52ND-Bifidobacterium-Rosell-175/dp/B00ZMO7UKW)
| 3 |
Anyone on Viibryd
|
I must say it may work better than the SSRIS
However, the sexual problems seem the same
| 3 |
mirtazapine 15 mg
|
i’ve been on it for like 3 days.
and i just feel so akward and numbed out in a way i like can’t talk to anyone or have any emotion
but it seems to be helping me cognitively
i still am having anxiety tho and obsessive thoughts
i struggle with
anhedonia, pssd , obsessive paranoid thoughts, anxiety , sleep issues, cognitive impairment
should i continue? my brain tells me to quit. i want to quit every med i start. i’ve never been able to get on one. and i’m just craving nicotine constantly even though i’ve quit vaping. what should i do?
| 1 |
We often talk about treatment regimes... sometimes it's good to just let the tears flow
| null | 6 |
any experience with increased depression and anxiety with opipramol?
|
Hello everyone, I have anxiety and depressive episodes. My doctor prescribed opipramol once a day until I see a therapist (which will happen in August) since the start of the medication I feel like I am more anxious, feel more hopeless and depressed. Morning are especially hard with anxiety and depressive thought. I feel as emotional and as anxious as in my PMS and I am not in my PMS.
Could it be the pill, I will talk to my doctor next week but I want to hear your experience too.
I happened to have very gard period in my life and I was hoping taking this pill will help me a bit, but I feel worse.
| 4 |
What can help me enjoy others company more and not get overwhelmed by them
|
It’s weird I get sad when I don’t get to spend time with loved ones but when I do I either feel overwhelmed by not feeling like I have anything meaningful to contribute due to anxiety and depression or I feel listless and the other persons energy about something which I can’t feel I can match makes me check out and I feel bad I didn’t even try to engage with them.
| 2 |
Treatment Resistant Depression
|
So far, I've tried all but the extremes (MAOIs, psychedelics) mostly due to the sides from the former and terrible insurance for the latter.
What off-label treatments has anyone tried that worked when the happy pills don't?
| 16 |
Recovery happens when you skive off groups and activities.
|
There will come a time in life, where you’ve tried every group, activity, medication, exercise programme known to man to control your depression? Don’t get me wrong, exercising does help with depression and so does fasting. But we’ve all tried that right?
What helps me feel better is when I don’t have engage with humans, people and could settle for a good book, listening to music or playing a game while long term sick.
Although these things can’t cure, depresssion but turning up support groups/groups in town is what actually caused my depression. So avoid this if you can.
Think about last time you went and showed up and felt even more depressed showing up then if you spent the day at home, work etc. imagine that activity you don’t like to do, make friends, engage with humans in the same way as very illegal drugs and then you would never turn up again.
Remember not all people are like this and some can be really nice. But you never meet anyone nice and friendly at mh support group or recovery community.
It’s not what you picture in the movies, a group of people having a chat in a semi circle. It’s certainly not what I pictured.
It’s more like a bunch of tossers, moaning about the weather endlessly or having mindless conversations, dropping feeling words into every sentence like it’s a fashion statement. Acting like total prats because they said they felt frustrated. Everyone feels these emotions dumbass.
Getting upset at most ridiculous things and acting like they are having an episode of severe depression because they didn’t post a letter. but all to show off to each other. Look at me. Things I would just say man up! It’s just a text message spelt wrong, it’s not rocket science.
You don’t get people at these groups with anything interesting to say or about their hobbies, work or what film they love or concerts they wanna see this year.
Just a bunch of assholes moaning about Sainsbury’s, town gossip and rubbish. Who said what, who did what? Dog shat on lawn
| 0 |
how does one get rid of negative obsessive thoughts without meds?
|
like neurotic crazyness? is there anything you can do besides numb it out with meds
| 6 |
I took a whole delta 9 gummy (20 mg) and still feel wrong 22 hours later.
|
I feel like I'm suffering bad memory impairment right now. I took my meds (15 mg mirtazapine and 200 mg gabapentin) thursday night and maybe they interacted to mess me up even more so. How long will this last?
| 12 |
Does abilify works?
|
There are many studyes telling , that abilify works good for treatment ressistant depression , is there any experience here , that have been heleped with add on abilify? And what other med combination.
| 1 |
The Fast-acting MDD Treatment Zuranolone Set for August FDA Approval Decision
| null | 18 |
Is there anything that comes close to being a miracle for depression, flight or fight anxiety, motivation issues, intrusive worrying thoughts etc?
| null | 12 |
For those that took Effexor and Cymbalta, which was the more effective of the two for you?
| null | 10 |
For those using Ketamine prescribed for Depression, what adverse effects do you notice?
|
I gotta admit, I am itching to see if doctor-prescribed Ketamine could really be beneficial for my mood.
That said, I have some precautions about potential side effects.
So for those who are wiser than me and have actually been on it, have you noticed any of the following?
\- Reduced concentration
\- Impaired memory
\- Addiction
\- Sexual dysfunction
​
These side effects are essentially the "hell-no's" for me.
| 11 |
Anyone taking armodafinil ??
|
Is armodafinil smoother thand modafnil ??
| 9 |
Treatment options, meds vs psychotherapy
|
I was just prescribed sertraline, I'm 39, and this is the first time in my life I've experienced depression. I have not started the medication. Counseling has been effective for me in the past for other issues I've faced. Is it naive of me to think that counseling could help me and I may not need the medication?
| 6 |
Ketamine infusions in Oxford
|
Hey, everyone!
I have been struggling with treatment-resistant depression for 7 years and I am actually prepared to get ECT done. However, I would try Ketamine before that.
Has anyone here applied for infusions at the [Oxford NHS-based clinic](https://www.oxfordhealth.nhs.uk/ketamine/) (Warneford Hospital, Oxford, OX3 7JX)? Would you please tell me whether there are pitfalls when applying? Maybe something you should better not mention in the application (I know that's my doctor actually who makes the application, but you can always ask them to highlight or maybe not reveal in your story)?
The reason I am asking these questions is that I've already heard from a couple of people that they were for some reason rejected by the hospital, which makes me worrisome.
| 4 |
Prescribed Abilify 2mg on it's own, Feeling unsure about taking it
|
I picked up my Rx for Abilify 2mg today, but I'm beginning to have second thoughts. It was prescribed to me to treat depression that I've struggled with for years.
I had mild results with Lexapro and Wellbutrin, but they were more numbing to me than anything else. I'm really quite desperate to start enjoying my life again- and have the motivation and focus on the things and people I love.
I wouldn't call my depression severe. It hasn't been debilitating- I still work and function around my friends and family well enough, I guess. Is this anti-psychotic really worth a shot? Has anyone had a similar experience?
I'll be taking Abilify on it's own with no other medication.
| 3 |
Does atomoxetine has stimulant property???
| null | 5 |
what is the best med for
|
obsessive, paranoia, anxiety, sexual dysfunction , and anhedonia?
| 1 |
GAD; Lexapro, Valdoxan and Ritalin
|
So I have Generalized anxiety disorder (GAD) and was prescribed 20mg Lexapro in 2020 which worked fine. There was low motivation and some depression but no anxiety.
I started taking Ritalin a year ago for motivation and adhd symptoms but my GAD is back. I started Valdoxan 4 months ago but it's not working. Is there any medicine that I should consider taking in addition to these? Preferably for GAD?
I live in Pakistan and it's really difficult to get doctors to prescribe antidepressants. However I can purchase them without prescription. Please help as I'm in a very tough spot in my life rn 🥺
| 2 |
Clomipramine and mirtazapine combo?
|
Currently on mirtazapine 30 mg and vortioxetine 5 mg.
I was on the past up to 20 mg vortioxetine but I consider it a mild antidepressant
Thinking on my next visit to ask to replace it with clomipramine starting in a low dose and keeping mirtazapine at 15 mg or less to help with initial anxiety rise due to clomipramine or perhaps add clonazepam short term
Any experience / suggestion is appreciatted
| 2 |
About Nihilism, Depression and Suicide
| null | 6 |
Zoloft, Rexulti
|
I was on Paxil for 18 years and after a period of extreme stress, it no longer worked for my anxiety. I weaned off of Paxil and went on Zoloft and it was honestly the worst time
Of anxiety in my life. I miss Paxil so much but it didn’t help with depression. I find that Zoloft helps with my depression just not my anxiety. I was in a car accident in January and my anxiety returned to a bad place.
My psychiatrist added in .5 of Rexulti and I feel a bit better but not at the level I want to be. I’m also in CBT Therapy and it helps. I want something that works like Paxil for anxiety and Zoloft for depression. Any recommendations? If Zoloft is not working at 250MG it’s likely not for me.
Thank you all for your help.
| 4 |
What pharmaceutical medication should I try next?
|
Hello,
For almost 3 years now I've been dealing with Sexual Dysfunction and Emotional Numbness.
Regarding the sexual dysfunction I have Erectile Dysfunction. I no longer wake up in the morning with an erection and I also no longer get erections throughout the day.
My sex drive is gone. I no longer feel any sexual arousal, desire, or attraction.
I also notice that I have reduced sensitivity to my penis.
With the emotional numbness, my emotions have been stripped from me. I feel like a zombie 24/7. I can no longer feel strong emotions like adrenaline, arousal, pleasure, etc. I can't laugh like I used to.
Other symptoms I have in addition to this are a reduced appetite, muscle aches, and brain fog.
These symptoms all began after an intense and chronic episode of stress, depression, and anxiety.
It's like that episode caused inflammation to my body and brain chemistry.
I no longer feel stressed, anxious, or depressed but I am still left with these symptoms of emotional numbness and sexual dysfunction.
Two practitioners brought to my attention that I may be dealing with Anhedonia.
I've been seeing a Psychiatrist to address that.
My Psychiatrist put me on Wellbutrin. I was on Wellbutrin for 6 months. I started off at 150MG, then 300MG, then 400MG. The Wellbutrin didn't help. Then he paired the Wellbutrin with Rexulti and I still felt no effect. He then had me try Trintellix and that didn't help. He currently put me on Auvelity and I've been taking it for 8 weeks. I don't feel a difference on it.
I follow up with my Psychiatrist next week and I am going to have to tell him that the Auvelity is not helping.
I'm not sure what to try next which is why I am asking you guys what do you think I should try?
| 4 |
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