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The study objectives were to evaluate the safety , tolerability , and preliminary efficacy of multiple doses of dulanermin in combination with modified FOLFOX6 and bevacizumab in previously untreated patients with locally advanced , recurrent , or metastatic colorectal cancer . | [{'class': 'POS', 'spans': ['dulanermin', 'FOLFOX6', 'bevacizumab'], 'is_context_needed': True}] |
Inhalatory beta2-mimetics with long-term action ( LABA ) , formoterol and salmeterol , possess a period of action longer than 12 hours . | [] |
This study evaluates the possible protective effects of the calcium channel blocker amlodipine , the angiotensin converting enzyme inhibitor lisinopril , and the xanthine oxidase inhibitor allopurinol against experimental acetaminophen-induced hepatotoxicity , aiming to understand its underlying hepatotoxic mechanisms . | [] |
The study was conducted in 90 patients operated on for unilateral breast cancer who were then assigned to receive either 12 intravenous cycles of cyclophosphamide , methotrexate and fluorouracil ( CMF ) every three weeks , or no further treatment . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'methotrexate', 'fluorouracil'], 'is_context_needed': True}] |
This study compared the efficacy of topical emedastine 0.05 % ophthalmic solution with that of oral loratadine 10 mg and their combination in the conjunctival allergen challenge model of allergic conjunctivitis . | [{'class': 'POS', 'spans': ['emedastine', 'loratadine'], 'is_context_needed': True}] |
Erythromycin , clindamycin and carbenicillin suppressed the donor flora permanently , as could be seen by the reduced colonization resistance . | [] |
Mycophenolate mofetil resulted in rapid improvement of steroid-refractory immune-related adverse event hepatitis , induced by nivolumab plus ipilimumab . | [{'class': 'COMB', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': True}] |
The mannose-linked prodrugs of saquinavir and indinavir display therefore a most promising therapeutic potential provided that bioavailability , penetration into the HIV infected macrophages , and HIV-reservoirs of these PIs are improved . | [] |
Resistant isolates emerged quickly and uniformly in all patients administered nevirapine either as monotherapy or in combination with zidovudine ( AZT ) . | [{'class': 'COMB', 'spans': ['nevirapine', 'zidovudine'], 'is_context_needed': True}] |
Postoperative combination chemotherapy for six cycles with cisplatin ( 100 mg/m2 per day for 1 day every 3 weeks ) , bleomycin ( 15 units intravenously weekly for 18 weeks ) and etoposide ( 100 mg/m2 per day for 3 days every 3 weeks ) were given and the tumor responded dramatically . | [{'class': 'POS', 'spans': ['cisplatin', 'bleomycin', 'etoposide'], 'is_context_needed': False}] |
The other received chemotherapy including prednisone , vincristine , cytarabine and L-asparaginase , combined with intrathecal injections of methotrexate , dexamethasone and Ara-C and supporting treatment . | [{'class': 'POS', 'spans': ['prednisone', 'vincristine', 'cytarabine', 'L-asparaginase'], 'is_context_needed': True}] |
Then , neoadjuvant chemotherapy ( NAC ) consisting of a combination of 5-fluorouracil ( 5-FU ) , oxaliplatin , irinotecan , and leucovorin ( FOLFOXIRI ) was planned , followed by primary tumor resection . | [{'class': 'POS', 'spans': ['5-fluorouracil', 'oxaliplatin', 'irinotecan', 'leucovorin'], 'is_context_needed': True}] |
Interestingly , aspirin not only significantly inhibited the growth of TNBC cells , but also attenuated YAP and β-catenin expression by upregulating the E3 ubiquitin ligase β-TrCP to abolished docetaxel and vinorelbine resistance . | [{'class': 'POS', 'spans': ['aspirin', 'docetaxel', 'vinorelbine'], 'is_context_needed': False}] |
No alterations in paclitaxel or doxorubicin pharmacokinetics were observed when the drugs were administered alone versus in combination . | [{'class': 'COMB', 'spans': ['paclitaxel', 'doxorubicin'], 'is_context_needed': True}] |
Twenty-seven received rituximab mainly in addition to high-dose cytarabine and etoposide ( n = 18 ) and/or ifosfamide , carboplatin , and etoposide ( n = 7 ) . | [{'class': 'COMB', 'spans': ['rituximab', 'cytarabine', 'etoposide', 'ifosfamide', 'carboplatin', 'etoposide'], 'is_context_needed': True}] |
A significant reduction in plasma 8-isoprostane and oxLDL levels was observed in all treatment groups [ by 10 % , 8 % and 6 % ( p < 0.05 compared with baseline ) and 41 % , 40 % and 39 % ( p < 0.001 compared with baseline ) in simvastatin , simvastatin/ezetimibe and rosuvastatin groups , respectively ] . | [] |
Both mono and combination therapies achieved the primary efficacy parameters : lowered diastolic blood pressure ( at trough ) more than placebo , p < 01 ( except the 120 mg verapamil SR , NS , 0.5 mg trandolapril , 0.5/180 and 2/120 combinations , p < 05 ) , yielded a trough to peak ratio of > 0.52 and had higher percentages of responders compared to placebo . | [{'class': 'POS', 'spans': ['verapamil', 'trandolapril'], 'is_context_needed': False}] |
In metastastic patients , the combination of gemcitabine and cisplatin has become the new standard regimen due to a lower toxicity in comparison to the combination of methotrexate , vinblastine , doxorubicin , and cisplatin ( MVAC ) . | [{'class': 'POS', 'spans': ['gemcitabine', 'cisplatin'], 'is_context_needed': False}, {'class': 'COMB', 'spans': [1, 2, 3], 'is_context_needed': True}] |
In the last few years , a flurry of new and more potent ALK inhibitors has emerged for the treatment of ALK-positive NSCLC , including ceritinib ( LDK378 ) , alectinib ( RO5424802/CH5424802 ) , AP26113 , ASP3026 , TSR-011 , PF-06463922 , RXDX-101 , X-396 , and CEP-37440 . | [] |
A randomized clinical trial of adjuvant chemotherapy with doxorubicin , ifosfamide , and cisplatin followed by radiotherapy versus radiotherapy alone in patients with localized uterine sarcomas ( SARCGYN study ) . | [{'class': 'POS', 'spans': ['doxorubicin', 'ifosfamide', 'cisplatin'], 'is_context_needed': True}] |
Combination therapy with irinotecan ( CPT-11 ) , 5-fluorouracil ( 5-FU ) and leucovorin is widely used for the treatment of metastatic colorectal cancer . | [{'class': 'POS', 'spans': ['irinotecan', 'leucovorin', '5-fluorouracil'], 'is_context_needed': True}] |
Long-term safety and outcome of fludarabine , cyclophosphamide and mitoxantrone ( FCM ) regimen in previously untreated patients with advanced follicular lymphoma : 12 years follow-up of a phase 2 trial . | [{'class': 'POS', 'spans': ['fludarabine', 'cyclophosphamide', 'mitoxantrone'], 'is_context_needed': True}] |
After clinical improvement under vemurafenib monotherapy , four cycles of ipilimumab were additionally administered . | [{'class': 'POS', 'spans': ['vemurafenib', 'ipilimumab'], 'is_context_needed': True}] |
Bevacizumab plus paclitaxel versus bevacizumab plus capecitabine as first-line treatment for HER2-negative metastatic breast cancer ( TURANDOT ): primary endpoint results of a randomised , open-label , non-inferiority , phase 3 trial . | [{'class': 'POS', 'spans': ['bevacizumab', 'capecitabine'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}] |
She underwent rectectomy and adjuvant chemotherapy with fluorouracil , leucovorin plus oxaliplatin for stage IIIB rectal cancer . | [{'class': 'COMB', 'spans': ['fluorouracil', 'leucovorin', 'oxaliplatin'], 'is_context_needed': True}] |
We designed this phase II trial to evaluate the safety , tolerability , and efficacy of the combination of carboplatin , paclitaxel , cetuximab , and bevacizumab in chemotherapy-naive patients with advanced , nonsquamous NSCLC . | [{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel', 'cetuximab', 'bevacizumab'], 'is_context_needed': True}] |
All patients underwent mexiletine monotherapy ( M-mono ) , propafenone monotherapy ( P-mono ) , low dose combination therapy ( low M+P ) , and full dose combination therapy ( full M+P ) . | [{'class': 'POS', 'spans': ['mexiletine', 'propafenone'], 'is_context_needed': True}] |
Cephalexin , 500 mg 4 times daily , plus trimethoprim-sulfamethoxazole , 320 mg/1600 mg twice daily , for 7 days ( n = 248 participants ) or cephalexin plus placebo for 7 days ( n = 248 participants ) . | [{'class': 'COMB', 'spans': ['Cephalexin', 'trimethoprim-sulfamethoxazole'], 'is_context_needed': True}] |
In the NALA trial , neratinib plus capecitabine led to increased PFS and time to intervention for central nervous system disease over the standard regimen of lapatinib plus capecitabine . | [{'class': 'POS', 'spans': ['neratinib', 'capecitabine'], 'is_context_needed': False}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': False}] |
Since the patient had anemia , aspirin and cilostazol were discontinued after diagnosis . | [{'class': 'NEG', 'spans': ['aspirin', 'cilostazol'], 'is_context_needed': True}] |
This case report describes a patient with O-NHL which was possibly linked to the combination of methotrexate and etanercept for the treatment of her rheumatoid arthritis . | [{'class': 'NEG', 'spans': ['methotrexate', 'etanercept'], 'is_context_needed': False}] |
In a prospective , pragmatic , randomised , parallel group study , 170 patients of mean ( SD ) age 37 ( 12 ) years with acute asthma ( peak expiratory flow ( PEF ) 212 ( 80 ) l/min ) presenting to hospital received treatment with either high dose prednisolone and continuous nebulised salbutamol as recommended in the US or lower dose prednisolone and bolus nebulised salbutamol as recommended in the UK by the BTS . | [{'class': 'POS', 'spans': ['prednisolone', 'salbutamol'], 'is_context_needed': True}] |
We report a case of a 78-year-old white male ( weight , 90 kg ) presented to the Department of Medical Oncology and Hematology , Istituto Clinico Humanitas , Rozzano , Milan , Italy , with refractory MM immunoglobulin G kappa ( IgGkappa ) , Durie-Salmon Stage IIA , with progressive renal failure after an oral melphalan , prednisone , and thalidomide regimen ( 4 mg/m2.d , 40 mg/m2.d for 7 days every 6 weeks , and 100 mg/d , respectively ) . | [{'class': 'NEG', 'spans': ['melphalan', 'prednisone', 'thalidomide'], 'is_context_needed': False}] |
Following an intravitreal injection of ranibizumab , off-label administration of intravitreal dexamethasone was considered to reduce the edema . | [{'class': 'POS', 'spans': ['ranibizumab', 'dexamethasone'], 'is_context_needed': False}] |
Rabeprazole was similar to omeprazole and superior to placebo in both maintenance of healing and prevention of symptoms in patients with healed GERD in 1-year studies . | [] |
We performed a prospective , preplanned , pooled analysis of six randomized , phase 3 trials that were conducted concurrently to evaluate the noninferiority of adjuvant therapy with either FOLFOX ( fluorouracil , leucovorin , and oxaliplatin ) or CAPOX ( capecitabine and oxaliplatin ) administered for 3 months , as compared with 6 months . | [{'class': 'POS', 'spans': ['capecitabine', 'oxaliplatin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1, 2], 'is_context_needed': True}] |
Growth inhibition and apoptosis were significantly ( P < 0.05 ) higher in BxPC-3 , HPAC , and PANC-1 cells treated with celecoxib and erlotinib than cells treated with either celecoxib or erlotinib . | [{'class': 'POS', 'spans': ['celecoxib', 'erlotinib'], 'is_context_needed': False}] |
Subcutaneous aspirin , 100 mg/kg , which reduced duodenal PGE2 generation to a greater degree than either ulcerogen , given in conjunction with pentagastrin , did not produce visible duodenal ulceration.(ABSTRACT TRUNCATED AT 250 WORDS ) | [] |
Prevalence of metronidazole , clarithromycin , and amoxicillin resistance is high in developing world including Africa . | [] |
These results indicate that low-dose 100 microg levonorgestrel and 20 microg ethinyl estradiol given for 21 days is effective in suppressing ovarian activity and they confirm the contraceptive efficacy observed in clinical trials ( Pearl index of 0.8 ) . | [{'class': 'POS', 'spans': ['levonorgestrel', 'ethinyl'], 'is_context_needed': False}] |
The combination of ixabepilone and capecitabine in the phase II study resulted in an ORR of 23 % in triple-negative patients . | [{'class': 'POS', 'spans': ['ixabepilone', 'capecitabine'], 'is_context_needed': True}] |
We report the rare case of a 27-year-old premenopausal woman with locally advanced breast cancer that was marked by rapid tumor necrosis followed by massive hemorrhage shortly after bevacizumab and paclitaxel administration . | [{'class': 'NEG', 'spans': ['bevacizumab', 'paclitaxel'], 'is_context_needed': False}] |
More recently , paclitaxel plus carboplatin also has been evaluated in previously untreated patients . | [{'class': 'COMB', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}] |
Mitoxantrone and cyclophosphamide in advanced breast cancer : a pilot study . | [{'class': 'POS', 'spans': ['Mitoxantrone', 'cyclophosphamide'], 'is_context_needed': True}] |
We retrospectively analyzed the data of 37 patients who had postprandial hyperglycemia ( ≥10.0 mmol/L ) with BOT ( long-acting insulin plus glimepiride ) with their insulin titrated enough to keep preprandial glycemia < 7.2 mmol/L , and who had their treatment changed to liraglutide monotherapy , with the subsequent addition of glimepiride , when required . | [{'class': 'COMB', 'spans': ['liraglutide', 'glimepiride'], 'is_context_needed': True}] |
It was shown that the H2 receptor antagonist cimetidine when combined with N , N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine-HCl ( DPPE ) , a tamoxifen derivate , inhibits the proliferation of HT168 cells . | [{'class': 'POS', 'spans': ['cimetidine', 'DPPE', 'N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine-HCl'], 'is_context_needed': False}] |
We report here on a case of successful treatment of a patient suffering with severe liver dysfunction and metastatic gastric cancer ; the patient was treated with a combination of capecitabine and oxaliplatin ( XELOX ) . | [{'class': 'POS', 'spans': ['capecitabine', 'oxaliplatin'], 'is_context_needed': False}] |
From 1987 to 1991 , 194 previously untreated patients received vincristine and ifosfamide plus dactinomycin or etoposide for 1 - 2 years . | [{'class': 'NEG', 'spans': ['vincristine', 'ifosfamide', 'dactinomycin'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 1, 3], 'is_context_needed': True}] |
This nested substudy of the AVALON trial assessed the effects of coadministered amlodipine and atorvastatin vs. either therapy alone or placebo on arterial compliance , to evaluate the vascular benefits of coadministered therapy . | [{'class': 'POS', 'spans': ['amlodipine', 'atorvastatin'], 'is_context_needed': True}] |
We analysed the serial dermatoscopic photographs of atypical melanocytic lesions taken from patients with advanced metastatic melanoma on four different systemic therapies ( selective BRAF-inhibitor monotherapy , dabrafenib combined with trametinib [ D&T ] , anti-programmed cell death protein 1 [ anti-PD1 ] therapies , and anti-PD1 combined with ipilimumab ) seen from February 2013 to May 2016 . | [{'class': 'COMB', 'spans': ['dabrafenib', 'trametinib'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3], 'is_context_needed': True}] |
He received six cycles MOPP-induction therapy followed by a chlorambucil maintenance therapy with procarbazine and prednisone reinforcements . | [{'class': 'NEG', 'spans': ['chlorambucil', 'procarbazine', 'prednisone'], 'is_context_needed': True}] |
The introduction of rituximab , alemtuzumab , and bendamustine has improved the current outlook for patients with CLL . | [] |
Ten patients were treated with pirfenidone ( 2403 mg/die ) and 1 with nintedanib | [] |
More recently , case-control and cohort studies and well-conceived , phase II/III clinical trials have been done or are under way to evaluate putative chemopreventive agents including established drugs like aspirin and non-steroidal anti-inflammatory drugs ( NSAIDs ) , 5-aminosalicylates and statins ; more controversial drugs like cyclo-oxygenase-2 ( COX-2 ) inhibitors , ursodeoxycholic acid ; various vitamins and micronutrients including calcium , selenium , folic acid , and dietary fibre , fat and protein content . | [] |
Frontline bortezomib and rituximab for the treatment of newly diagnosed high tumour burden indolent non-Hodgkin lymphoma : a multicentre phase II study . | [{'class': 'POS', 'spans': ['bortezomib', 'rituximab'], 'is_context_needed': True}] |
The ifosfamide , carboplatin and etoposide ( ICE ) regimen was developed to address these challenges . | [{'class': 'POS', 'spans': ['ifosfamide', 'carboplatin', 'etoposide'], 'is_context_needed': True}] |
Tofacitinib combination therapy was also associated with the lower PMPM cost compared with adalimumab combination therapy in the TNF-IR analysis . | [] |
Effect of sequential treatments with alendronate , parathyroid hormone ( 1 - 34 ) and raloxifene on cortical bone mass and strength in ovariectomized rats . | [{'class': 'POS', 'spans': ['alendronate', 'parathyroid hormone', 'raloxifene'], 'is_context_needed': True}] |
Atorvastatin and metformin both have pleiotropic effects . | [{'class': 'POS', 'spans': ['Atorvastatin', 'metformin'], 'is_context_needed': True}] |
Bevacizumab , a monoclonal antibody targeting vascular endothelial growth factor , is the first antiangiogenic drug to show improved efficacy when used in combination with irinotecan and oxaliplatin for first- and second-line treatment of CRC . | [{'class': 'POS', 'spans': ['Bevacizumab', 'irinotecan', 'oxaliplatin'], 'is_context_needed': False}] |
Available data indicate that GLY and aclidinium have similar efficacy to tiotropium in terms of improving lung function , dyspnea , exacerbations , and health status . | [] |
Between Oct 24 , 2016 , and Jan 24 , 2018 , 861 patients were randomly assigned to receive pembrolizumab plus axitinib ( n=432 ) or sunitinib monotherapy ( n=429 ) . | [{'class': 'POS', 'spans': ['pembrolizumab', 'axitinib'], 'is_context_needed': True}] |
Patients received 175 mg/m of paclitaxel over a 3 h infusion , followed by nedaplatin 80 mg/m in a 1 h infusion on day 1 every 3 weeks for up to 6 treatment cycles . | [{'class': 'POS', 'spans': ['paclitaxel', 'nedaplatin'], 'is_context_needed': True}] |
After a median follow-up of 9.5 years , 10-year OS rates in the bolus/infusional fluorouracil plus leucovorin ( LV5FU2 ) and LV5FU2 plus oxaliplatin ( FOLFOX4 ) arms were 67.1 % versus 71.7 % ( hazard ratio [ HR ] , 0.85 ; P = .043 ) in the whole population , 79.5 % versus 78.4 % for stage II ( HR , 1.00 ; P = .980 ) , and 59.0 % versus 67.1 % for stage III ( HR , 0.80 ; P = .016 ) disease . | [{'class': 'POS', 'spans': ['fluorouracil', 'leucovorin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}] |
[ Effects of combined use of dofetilide and verapamil on the action potential of papillary muscles in guinea pigs ] . | [{'class': 'POS', 'spans': ['dofetilide', 'verapamil'], 'is_context_needed': True}] |
Patients with pancreatic adenocarcinoma , pre-treated with gemcitabine-based chemotherapy , were treated with capecitabine ( 800 mg/m(2 ) orally , twice a day for 14 days ) and docetaxel ( 75 mg/m(2 ) i.v , on day 1 ) , every 3 weeks . | [{'class': 'POS', 'spans': ['capecitabine', 'docetaxel'], 'is_context_needed': True}] |
Comparative study of dose escalation versus interval reduction to obtain dose-intensification of epirubicin and cyclophosphamide with granulocyte colony-stimulating factor in advanced breast cancer . | [{'class': 'POS', 'spans': ['epirubicin', 'cyclophosphamide'], 'is_context_needed': True}] |
The hearts were treated during the whole procedure either with vehicle , 0.5 μM flecainide ( sodium channel blocker ) or 100 μM streptomycin ( here used as stretch-activated ion-channel blocker ) . | [{'class': 'COMB', 'spans': ['flecainide', 'streptomycin'], 'is_context_needed': True}] |
In the APHINITY study ( NCT01358877 , BIG 4 - 11/BO25126/TOC4939 G ) , pertuzumab added to trastuzumab and chemotherapy significantly improved invasive disease-free survival as adjuvant treatment for patients with HER2-positive early breast cancer . | [{'class': 'POS', 'spans': ['pertuzumab', 'trastuzumab'], 'is_context_needed': False}] |
In two trials , an anti-EGFR antibody ( panitumumab or cetuximab ) reduced median survival when added to bevacizumab in previously untreated patients . | [{'class': 'NEG', 'spans': ['panitumumab', 'bevacizumab'], 'is_context_needed': False}, {'class': 'NEG', 'spans': [1, 2], 'is_context_needed': False}] |
The results of the APPEARANCE trial indicate that adapalene does not prevent acne-like rash over placebo when added to topical moisturizer and oral minocycline but instead may have a detrimental effect . | [{'class': 'NEG', 'spans': ['adapalene', 'minocycline'], 'is_context_needed': False}] |
Both regimens included cyclophosphamide , methotrexate , 5-FU , prednisone , and doxorubicin . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin'], 'is_context_needed': True}] |
In 2011 , new drugs were approved by the U.S. Food and Drug Administration , including peginterferon alfa-2b for patients with stage III disease , vemurafenib for patients with metastatic melanoma with the BRAF V600E mutation , and ipilimumab , a monoclonal antibody directed to the CTLA-4 T lymphocyte receptor , to combat metastatic melanoma in patients who do not have the BRAF V600E mutation . | [] |
Individual studies have reported differences between antiandrogens in terms of both tolerability and efficacy-for example , bicalutamide has been shown to be better tolerated than flutamide , and may be associated with improved survival . | [] |
A Randomized , Multicenter , Double-blind , Phase III Study to Evaluate the Efficacy on Allergic Rhinitis and Safety of a Combination Therapy of Montelukast and Levocetirizine in Patients With Asthma and Allergic Rhinitis . | [{'class': 'POS', 'spans': ['Montelukast', 'Levocetirizine'], 'is_context_needed': True}] |
Intravenous administration of cefoperazone and sulbactam given as individual agents compared with the combination did not show pharmacokinetic differences that are likely to produce clinically relevant effects . | [{'class': 'COMB', 'spans': ['cefoperazone', 'sulbactam'], 'is_context_needed': True}] |
HDC with cyclophosphamide , carmustine and thiotepa was given from day -7 to -5 . | [{'class': 'COMB', 'spans': ['cyclophosphamide', 'carmustine', 'thiotepa'], 'is_context_needed': True}] |
Melatonin or sulpiride could replace these environmental factors . | [] |
Trastuzumab and Pertuzumab Plant Biosimilars : Modification of Asn297-linked Glycan of the mAbs Produced in a Plant with Fucosyltransferase and Xylosyltransferase Gene Knockouts . | [] |
A recently reported phase II trial has demonstrated that trastuzumab plus vinorelbine is both effective ( overall response rate 75 % ) and well tolerated , with the major side effects being typical of single-agent vinorelbine . | [{'class': 'POS', 'spans': ['trastuzumab', 'vinorelbine'], 'is_context_needed': False}] |
Men with prostate cancer were randomly assigned to one of four treatment arms : leuprorelin , goserelin , cyproterone acetate ( CPA ) , or close clinical monitoring . | [] |
There were no significant differences between the two treatment groups , except that amantadine was inferior to mycophenolate mofetil regarding the outcome failure to achieve end-of treatment virological response ( low quality of evidence ) . | [] |
Furthermore , more incidences of severe fatigue , thrombocytopenia , and neutropenia were recorded for sunitinib , but pazopanib had more liver toxicity . | [] |
Streptomycin appears to be the most effective agent followed by gentamicin and the least active was netilmicin . | [] |
Neither behavioral therapy , clomipramine , methylphenidate , buspirone , nor naltrexone was effective in monotherapeutic trials . | [] |
Pharmacokinetic PET imaging data analysis quantitatively showed the pharmacological effects of teriparatide-induced suppression of upper gastrointestinal motility and its restoration by granisetron and mosapride . | [] |
Differences were observed when palbociclib or ribociclib was used in combination with letrozole or anastrozole or fulvestrant . | [{'class': 'COMB', 'spans': ['palbociclib', 'letrozole'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 3], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 4], 'is_context_needed': True}] |
Resolution of muscle damage followed discontinuation of cyclosporine and lovastatin therapy . | [{'class': 'NEG', 'spans': ['cyclosporine', 'lovastatin'], 'is_context_needed': False}] |
In order to elucidate the possible interference of the antiparkinson drug 1-aminoadamantane ( D-1 , PK Merz ) and the antispastic compound 1,3-dimethyl-5-aminoadamantane ( DMAA , D-145 , memantine , Memantine ) on neurotransmitter metabolism , the effect of D-1 and its C-alkyl derivatives memantine , 1-amino-3,5,7-trimethyladamantane ( D-191 ) , and 1-amino-3-(n)-butyladamantane ( D-178 ) on MAO activity in brain , liver , and kidney of the rat was investigated . | [] |
Primary chemotherapy with gemcitabine , liposomal doxorubicin and docetaxel in patients with locally advanced breast cancer : results of a phase I trial . | [{'class': 'POS', 'spans': ['gemcitabine', 'doxorubicin', 'docetaxel'], 'is_context_needed': True}] |
A single bolus of dexamethasone , given before a single large meal , produces a delayed ( 6-hour ) but long-lasting increase in serum leptin ( over 16 hours ) . | [] |
The aim of this single-blind , randomized , controlled trial was to investigate treatment efficacy and safety of aripiprazole as an adjunct to valproic acid ( Ari+Val ) , compared with haloperidol plus valproic acid ( Hal+Val ) , in acute manic patients . | [{'class': 'POS', 'spans': ['aripiprazole', 'valproic'], 'is_context_needed': True}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': True}] |
Because the incidence of nausea and vomiting is significantly reduced when ketorolac is used in place of opioids to attenuate postoperative pain , it would appear to be an appropriate choice of agent to use following propofol anesthesia . | [{'class': 'POS', 'spans': ['ketorolac', 'propofol'], 'is_context_needed': False}] |
The combination of vandetanib and bicalutamide was associated with considerable toxicity and did not have superior efficacy over bicalutamide alone . | [{'class': 'NEG', 'spans': ['vandetanib', 'bicalutamide'], 'is_context_needed': False}] |
Our data indicate that the addition of Aspirin or of Atenolol to Metformin might be beneficial for BC control , and that this activity is likely due to effects on both BC and microenvironment cells . | [{'class': 'POS', 'spans': ['Aspirin', 'Metformin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': False}] |
Coadministration of vorinostat and oxaliplatin induced G2/M phase arrest , triggered caspase-dependent apoptosis , and decreased tumorigenicity both in vitro and in vivo . | [{'class': 'POS', 'spans': ['vorinostat', 'oxaliplatin'], 'is_context_needed': False}] |
Randomized open trial of gentamicin and doxycycline for eradication of Bartonella quintana from blood in patients with chronic bacteremia . | [{'class': 'POS', 'spans': ['gentamicin', 'doxycycline'], 'is_context_needed': True}] |
The role of dual antiplatelet therapy combining aspirin and clopidogrel , is controversial . | [{'class': 'COMB', 'spans': ['aspirin', 'clopidogrel'], 'is_context_needed': True}] |
We conducted a dose-escalating study of daunorubicin combined to fixed doses of IM ( imatinib mesylate , 600 mg/d ) and cytarabine ( 200 mg/d for 7 days ) , followed by hematopoietic stem cell transplantation or maintenance therapy with single-agent IM in patients with MBC-CML at onset or after failure of therapy excluding TKIs . | [{'class': 'POS', 'spans': ['daunorubicin', 'imatinib', 'cytarabine'], 'is_context_needed': True}] |
[ Combination chemo-endocrine therapy of metastatic and stage IV breast cancer with cyclophosphamide , adriamycin , prednisolone and tamoxifen (CAPT)--with special reference to management of brain and liver metastasis ] . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'adriamycin', 'prednisolone', 'tamoxifen'], 'is_context_needed': True}] |
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