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We found that melatonin in combination with all-trans retinoic acid and somatostatin potentiated the effects of melatonin alone on MCF-7 cell viability and growth inhibition ; this phenomenon was associated with altered conductance through Ca²⁺ and voltage-activated K⁺ ( BK ) channels , and with substantial impairments of Notch-1 and epidermal growth factor (EGF)-mediated signaling . | [{'class': 'POS', 'spans': ['melatonin', 'all-trans retinoic acid', 'somatostatin'], 'is_context_needed': True}] |
It was concluded that cytosine arabinoside in combination with vincristine and prednisone is an effective but toxic antileukemic regimen which did not produce a major improvement in remission duration . | [{'class': 'NEG', 'spans': ['cytosine arabinoside', 'vincristine', 'prednisone'], 'is_context_needed': False}] |
Patients were categorized into 10 groups according to the index OAC ( warfarin , rivaroxaban , dabigatran , apixaban , and edoxaban ) and whether or not they received PPI co-therapy , and were followed up for incidence of major GIB . | [] |
Celecoxib induced a synergistic or an additive cytotoxic effect in combination with doxorubicin , etoposide , irinotecan or vincristine in vitro . | [{'class': 'POS', 'spans': ['Celecoxib', 'doxorubicin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 3], 'is_context_needed': False}] |
In vivo , midostaurin alone powerfully prolonged the survival of mice bearing the resistant BL cells compared to rituximab alone treatments . | [] |
Treatment of GIST882-R with imatinib in combination with gefitinib , an EGFR inhibitor , partially prevented cell growth , implying that EGFR may be involved in acquisition of secondary imatinib resistance in GIST . | [{'class': 'POS', 'spans': ['imatinib', 'gefitinib'], 'is_context_needed': False}] |
This is the first paper suggesting the possibility of combination treatment of tamoxifen with risperidone in breast cancer patients , providing a conceivable resolution of tamoxifen-induced side effects without interfering the efficacy of tamoxifen against breast cancer . | [{'class': 'POS', 'spans': ['tamoxifen', 'risperidone'], 'is_context_needed': False}] |
Amoxicillin , erythromycin , and levofloxacin at supra-MIC concentrations were very active against planktonic cells of 3 selected strains but lower on biofilm-associated organisms in 2 strains and null against the third . | [{'class': 'POS', 'spans': ['Amoxicillin', 'erythromycin', 'levofloxacin'], 'is_context_needed': False}] |
A double-blind , parallel , placebo-controlled study was performed to assess the efficacy of a combination drug product containing the antihistamine , triprolidine , and the sympathomimetic , pseudoephedrine , in the treatment of allergic rhinitis . | [{'class': 'POS', 'spans': ['triprolidine', 'pseudoephedrine'], 'is_context_needed': True}] |
After surgery , 1,384 patients were randomly assigned to receive epirubicin plus cyclophosphamide ( EC ; 90 and 600 mg/m(2 ) , respectively , × four cycles ) , followed by docetaxel ( 100 mg/m(2 ) × four cycles ; EC-T ) or epirubicin plus docetaxel ( ET ; 90 and 75 mg/m(2 ) , respectively , × four cycles ) , followed by capecitabine ( 1,250 mg/m(2 ) twice a day on days 1 to 14 , × four cycles ; ET-X ) ; all regimens were given every 3 weeks . | [{'class': 'POS', 'spans': ['epirubicin', 'cyclophosphamide', 'docetaxel'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [3, 4, 5], 'is_context_needed': True}] |
This prospective study recruited 152 patients with locally advanced breast cancer who underwent four-cycle weekly paclitaxel plus carboplatin without trastuzumab . | [{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}] |
High response rate and acceptable toxicity of a combination of rituximab , vinorelbine , ifosfamide , mitoxantrone and prednisone for the treatment of diffuse large B-cell lymphoma in first relapse : results of the R-NIMP GOELAMS study . | [{'class': 'POS', 'spans': ['rituximab', 'vinorelbine', 'ifosfamide', 'mitoxantrone', 'prednisone'], 'is_context_needed': False}] |
A second complete remission was obtained with RFC chemotherapy regimen ( rituximab , fludarabine , and cyclophosphamide ) . | [{'class': 'POS', 'spans': ['rituximab', 'fludarabine', 'cyclophosphamide'], 'is_context_needed': False}] |
At a median duration of follow-up of 18.2 months , anastrozole was at least equivalent to tamoxifen in terms of median TTP ( 8.5 and 7.0 months , respectively ; estimated hazard ratio [ tamoxifen relative to anastrozole ] , 1.13 [ lower 95 % confidence level , 1.00 ] ) . | [] |
A favourable response to chemotherapy can be expected in up to 60 % of patients receiving a combination of streptozocin plus doxorubicin , and in up to 40 % of patients receiving dacarbazine . | [{'class': 'POS', 'spans': ['streptozocin', 'doxorubicin'], 'is_context_needed': False}] |
A substantial literature now strongly supports the specific involvement of serotonin 5-HT(1B ) and 5-HT(2C ) receptor subtypes in satiety and in the anorectic effect of agents such as fenfluramine and fluoxetine . | [] |
Pilocarpine also induced secretion at a concentration as low as 1 μM and was the most powerful secretagogue at 10 μM. Secretion was induced by carbachol at 0.1 μM , with maximum secretion at 1.0 μM. | [] |
This phase II study was conducted to establish whether induction chemotherapy with carboplatin ( CBDCA ) and paclitaxel ( PTX ) plus bevacizumab prior to surgery reduces the risk of progression . | [{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel', 'bevacizumab'], 'is_context_needed': True}] |
In women of childbearing potential , valproate should be considered if levetiracetam and lamotrigine have failed to control seizures at this stage . | [] |
Patients with clinically localized , intermediate- or high-grade non-Hodgkin 's lymphoma usually receive initial treatment with a doxorubicin-containing regimen such as cyclophosphamide , doxorubicin , vincristine , and prednisone ( CHOP ) . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin', 'vincristine', 'prednisone'], 'is_context_needed': False}] |
To evaluate the effects of a fixed combination of olmesartan/amlodipine compared with olmesartan or amlodipine alone on some parameters of endothelial damage in diabetic , hypertensive patients . | [{'class': 'POS', 'spans': ['olmesartan', 'amlodipine'], 'is_context_needed': True}] |
Numerous phase II and III clinical trials have demonstrated a higher activity of combined gemcitabine plus docetaxel schedules against non-small cell lung cancer ( NSCLC ) than that of both agents in monotherapy . | [{'class': 'POS', 'spans': ['gemcitabine', 'docetaxel'], 'is_context_needed': False}] |
The use of HDCT-SCT in CNS metastases needs to be carefully considered , possibly by adding thiotepa or topotecan to improve tumor control . | [] |
Targeted agents for HNSCC expected to improve the effectiveness of current therapy include EGFR inhibitors ( Cetuximab , Panitumumab , Zalutumumab ) , EGFR tyrosine kinase inhibitors ( Gefitinib , Erloitinib ) , VEGFR inhibitors ( Bevacizumab , Vandetanib ) , and various inhibitors of , e.g. , Src-family kinase , PARP , proteasome , mTOR , COX , and heat shock protein . | [] |
We performed a retrospective analysis of 114 severely head injured patients who were admitted to the neurocritical care unit of Level 1 trauma center and who received vasopressors ( phenylephrine , norepinephrine , dopamine , vasopressin or epinephrine ) to increase blood pressure | [] |
While 5-fluorouracil used as single agent in patients with metastatic colorectal cancer has an objective response rate around 20 % , the administration of combinations of irinotecan with 5-fluorouracil/folinic acid or oxaliplatin with 5-fluorouracil/folinic acid results in significantly increased response rates and improved survival . | [{'class': 'POS', 'spans': ['irinotecan', '5-fluorouracil/folinic'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 3], 'is_context_needed': False}] |
Chemotherapy was given in 405 of 410 treatment periods with dacarbazine , fotemustine , vindesine , carboplatin and temozolomide in different schedules . | [] |
[ Effect of nedaplatin , 5-FU , and leucovorin combined with radiation therapy in unresectable esophageal carcinoma ] . | [{'class': 'POS', 'spans': ['nedaplatin', 'leucovorin', '5-FU'], 'is_context_needed': True}] |
After 5 years , approximately 30.8 % of etanercept patients and 68.8 % of monoclonal antibody patients ( adalimumab 71.2 % ; infliximab 67.2 % ) were still being treated . | [] |
( 4 mg/day ) ; in group 3 , 69 patients administered metformin ( 1,000 mg/day ) and rosiglitazone ( 4 mg/day ) for 6 months , | [{'class': 'POS', 'spans': ['metformin', 'rosiglitazone'], 'is_context_needed': True}] |
In the intention-to-treat analysis , 57 % of patients that received tenecteplase and 53 % of patients that received alteplase reached good functional outcome ( modified Rankin Scale score of 0 - 1 ) at 3 months ( odds ratio , 1.19 ; 95 % CI , 0.68 - 2.10 ) . | [] |
The patient was treated with dexamethasone and ethinyl estradiol with cessation of anti-hypertensive therapy . | [{'class': 'COMB', 'spans': ['dexamethasone', 'ethinyl'], 'is_context_needed': True}] |
Exposure of bss1 to clinically-used antiepileptic drugs ( phenytoin or gabapentin ) significantly reduces synchrony . | [] |
When compared with the combination of amphotericin B plus flucytosine , fluconazole was similarly effective in early treatment of acute and subacute disseminated candidiasis . | [{'class': 'POS', 'spans': ['amphotericin', 'flucytosine'], 'is_context_needed': False}] |
Treatment of patients over 50 years of age with acute myelogenous leukemia with a combination of rubidazone and cytosine arabinoside , vincristine , and prednisone ( ROAP ) . | [{'class': 'POS', 'spans': ['rubidazone', 'cytosine arabinoside', 'vincristine', 'prednisone'], 'is_context_needed': True}] |
Patients progressing after first-line chemotherapy are treated with docetaxel , pemetrexed or erlotinib . | [] |
To compare the therapeutic effect of α(2 ) and α(4 ) integrin-blocking antibodies to conventional inflammatory bowel disease drugs methotrexate , 5-aminosalicylic acid and azathioprine in the dextran sulphate sodium mouse colitis model . | [{'class': 'POS', 'spans': ['methotrexate', '5-aminosalicylic acid', 'azathioprine'], 'is_context_needed': True}] |
Further analyses demonstrated that gemcitabine could significantly interfere with the cytotoxic effects of paclitaxel on both mitotic arrest and apoptotic cell death unless paclitaxel is administered before gemcitabine . | [{'class': 'POS', 'spans': ['paclitaxel', 'gemcitabine'], 'is_context_needed': True}] |
Standard anticonvulsants such as phenytoin , the barbiturates , carbamazepine , and the succinimides have been ineffective . | [] |
Molecular targeting of Aurora A by curcumin restores chemosensitivity by increasing the efficacy of doxorubicin in breast cancer. | [{'class': 'POS', 'spans': ['curcumin', 'doxorubicin'], 'is_context_needed': True}] |
Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma . | [{'class': 'POS', 'spans': ['Daratumumab', 'Lenalidomide', 'Dexamethasone'], 'is_context_needed': True}] |
Noninferiority was concluded if the lower limit of the 2-sided 95 % CI for the difference ( doripenem minus meropenem ) in the proportion of patients classified as clinical cures was > or=-15 % . | [] |
We further illustrate the practical considerations of managing irAEs by presenting three cases of immune-related toxicity in melanoma patients treated with nivolumab or pembrolizumab . | [] |
Randomized phase II trial of carboplatin and paclitaxel with or without lonafarnib in first-line treatment of epithelial ovarian cancer stage IIB-IV . | [{'class': 'NEG', 'spans': ['carboplatin', 'paclitaxel', 'lonafarnib'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1], 'is_context_needed': True}] |
One subject who received oxaprozin for 12 days and , in addition , aspirin for the last five days developed a rash that subsided after both drugs were discontinued ; one subject treated with aspirin experienced tinnitus . | [{'class': 'NEG', 'spans': ['oxaprozin', 'aspirin'], 'is_context_needed': False}] |
To determine the long-term tolerability of prophylactic administration of pyrazinamide and levofloxacin in patients possibly exposed to multidrug-resistant tuberculosis ( MDRTB ) after undergoing solid organ transplantation . | [{'class': 'NEG', 'spans': ['pyrazinamide', 'levofloxacin'], 'is_context_needed': True}] |
Additive effect of the combination of griseofulvin and ketoconazole against Microsporum canis in vitro . | [{'class': 'POS', 'spans': ['griseofulvin', 'ketoconazole'], 'is_context_needed': True}] |
Aprepitant plus ondansetron may increase acute-CR , may have benefit regarding CINV 's effect on QoL , and is safe for 5-day temozolomide compared to ondansetron . | [{'class': 'POS', 'spans': ['Aprepitant', 'ondansetron'], 'is_context_needed': True}] |
Finally , a further synergistically improved myeloma cell lysis with the daratumumab-IPH2102 combination was observed by adding lenalidomide , which suggests that more effective treatment strategies can be designed for multiple myeloma by combining daratumumab with agents that independently modulate natural killer cell function . | [{'class': 'POS', 'spans': ['lenalidomide', 'daratumumab'], 'is_context_needed': False}] |
Both liposomal doxorubicin ( LD ) and docetaxel ( D ) have a broad range of activity against solid tumors , including advanced pancreatic cancer ( APC ) , as single agents , while their combination has produced encouraging response rates in the treatment of several malignancies . | [{'class': 'POS', 'spans': ['doxorubicin', 'docetaxel'], 'is_context_needed': False}] |
Triple therapy with ranitidine or lansoprazole in the treatment of Helicobacter pylori-associated duodenal ulcer . | [] |
A study on the effect of cimetidine and L-carnitine on myoglobinuric acute kidney injury in male rats . | [{'class': 'POS', 'spans': ['cimetidine', 'L-carnitine'], 'is_context_needed': True}] |
Importantly , MAPK and/or MTOR complex1 ( MTORC1 ) activity were upregulated in AML cells made resistant to several FLT3 inhibitors , including crenolanib , quizartinib , or sorafenib . | [] |
We tested whether varenicline , a partial nicotine agonist , would also increase future quit attempts . | [] |
However , combination of pioglitazone and sulfasalazine has shown greater efficacy . | [{'class': 'POS', 'spans': ['pioglitazone', 'sulfasalazine'], 'is_context_needed': False}] |
At time 2 , genotypic resistance to zidovudine was found in 11 out of 12 cases ( 41L : two cases ; 41L , 215Y : six cases ; 41L , 210W , 215Y : two cases ; M41L , D67N , L210W , T215Y : one case ) with a mean 18.9 + /- 8.8-fold increase in the IC50 to zidovudine and 1.4 + /- 0.4-fold to stavudine | [] |
Phase II Study of Sorafenib Combined with Concurrent Hepatic Arterial Infusion of Oxaliplatin , 5-Fluorouracil and Leucovorin for Unresectable Hepatocellular Carcinoma with Major Portal Vein Thrombosis . | [{'class': 'POS', 'spans': ['Sorafenib', 'Oxaliplatin', '5-Fluorouracil', 'Leucovorin'], 'is_context_needed': True}] |
Sprague-Dawley male rats were treated with levodopa ( LD ) , betaine ( Bet ) , levodopa plus betaine ( LD/Bet ) , levodopa plus benserazide ( LD/Ben ) , levodopa plus betaine-benserazide ( LD/Bet-Ben ) , and the controls with vehicle for 10 consecutive days , orally . | [{'class': 'POS', 'spans': ['levodopa', 'benserazide'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3, 6, 7], 'is_context_needed': True}] |
We designed a phase I trial to determine the maximum-tolerated dose ( MTD ) and pharmacodynamic effects of the IGF-1R antibody Cixutumumab in combination with temsirolimus in patients with metastatic breast cancer refractory to standard therapies . | [{'class': 'POS', 'spans': ['Cixutumumab', 'temsirolimus'], 'is_context_needed': True}] |
Forty-seven percent of patients were sequentially treated with an amphotericin B-containing product followed by itraconazole , 31 % received itraconazole alone , and 7 % received an amphotericin B-containing product only . | [{'class': 'COMB', 'spans': ['amphotericin', 'itraconazole'], 'is_context_needed': True}] |
From August 2008 to May 2011 , consecutive chemo-naïve patients with stage IV non-squamous non-small cell lung cancer ( NSCLC ) received pemetrexed 500mg/m(2 ) , oxaliplatin 100mg/m(2 ) and bevacizumab 7.5mg/kg every 3 weeks for 6 cycles , in the outpatient setting . | [{'class': 'POS', 'spans': ['pemetrexed', 'oxaliplatin', 'bevacizumab'], 'is_context_needed': True}] |
To determine if antiseptic central venous catheters impregnated with silver sulfadiazine and chlorhexidine ( antiseptic ) reduce bacterial adherence and biofilm formation without producing local or systemic toxicity . | [{'class': 'POS', 'spans': ['sulfadiazine', 'chlorhexidine'], 'is_context_needed': True}] |
In multivariate analysis , LDP and LAP were significantly associated with stavudine ( d4 T ) use , while LAP was also associated with zidovudine ( ZDV ) treatment . | [] |
KARs , new semisynthetic antitumor bis-indole derivatives , were found to be inhibitors of tubulin polymerization with lower toxicity than vinblastine or vincristine , used in chemotherapy . | [] |
More than one-third ( 36 % ) of AA patients in our study received Danazol as monotherapy , whereas less than a third ( 32 % ) each received standard doses of IST with equine Anti Thymocyte Globulin ( ATG ) and Cyclosporine combination , or Cyclosporine and Danazol combination , respectively . | [{'class': 'NEG', 'spans': ['Cyclosporine', 'Danazol'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [1, 2], 'is_context_needed': True}] |
Similarly , antibodies raised against CYP3A4 almost completely abolished colchicine demethylation and nifedipine oxidase activity , but preimmune IgG had no effect . | [] |
Furthermore , our group has shown that the combination of paclitaxel and carboplatin is effective in anthracycline-resistant ABC . | [{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': False}] |
Cyclosporine ( 25 mg/kg per day , s.c . ) was given for 7 days to rats either alone or in combination with resveratrol ( 10 mg/kg per day , i.p . ) . | [{'class': 'POS', 'spans': ['Cyclosporine', 'resveratrol'], 'is_context_needed': True}] |
The diagnosis was confirmed by comparative double diagnostic block of the medial branch with bupivacaine and lidocaine . | [{'class': 'COMB', 'spans': ['bupivacaine', 'lidocaine'], 'is_context_needed': True}] |
Pemetrexed with bortezomib is feasible and tolerable at recommended single-agent doses . | [{'class': 'POS', 'spans': ['Pemetrexed', 'bortezomib'], 'is_context_needed': False}] |
Bevacizumab plus chemotherapy versus chemotherapy alone as second-line treatment for patients with HER2-negative locally recurrent or metastatic breast cancer after first-line treatment with bevacizumab plus chemotherapy ( TANIA ): an open-label , randomised phase 3 trial . | [{'class': 'POS', 'spans': ['bevacizumab', 'TANIA'], 'is_context_needed': True}] |
Goserelin plus tamoxifen after cyclophosphamide , doxorubicin and 5-fluorouracil ( CAF ) chemotherapy resulted in improved disease-free survival compared with CAF alone . | [{'class': 'POS', 'spans': ['Goserelin', 'tamoxifen', 'cyclophosphamide', 'doxorubicin', '5-fluorouracil'], 'is_context_needed': False}] |
An 82-year-old white female developed a 36-hour episode of unresponsiveness/drowsiness after a single dose of triazolam 0.5 mg in combination with cimetidine . | [{'class': 'NEG', 'spans': ['triazolam', 'cimetidine'], 'is_context_needed': False}] |
The combination of melatonin at concentrations of 50 μM with increasing doses of irinotecan ( 7.5 , 15 , 30 , and 60 μM ) resulted in an increase in the amount of DNA damage in A549 and HT29 cancer cells , but was not effective in inducing DNA damage in healthy human lymphocytes . | [{'class': 'POS', 'spans': ['melatonin', 'irinotecan'], 'is_context_needed': False}] |
Peripheral blood progenitor cells were harvested by leukapheresis after treatment with cyclophosphamide and filgrastim and then re-infused after the high-dose cycle . | [{'class': 'NEG', 'spans': ['cyclophosphamide', 'filgrastim'], 'is_context_needed': True}] |
Although cisplatin is generally the favoured platinum agent , gemcitabine partnered with carboplatin is convenient to administer and has a favourable toxicity profile . | [{'class': 'POS', 'spans': ['gemcitabine', 'carboplatin'], 'is_context_needed': False}] |
In group B , epirubicin 90 mg/m2 was combined with paclitaxel 175 mg/m2 , given in the same manner as in group A. | [{'class': 'POS', 'spans': ['epirubicin', 'paclitaxel'], 'is_context_needed': True}] |
We assessed the safety and activity of ceritinib plus nivolumab in these patients . | [{'class': 'COMB', 'spans': ['ceritinib', 'nivolumab'], 'is_context_needed': True}] |
Incubation with somatostatin , 5-aza decitabine and trichostatin up-regulates somatostatin receptor expression in prostate cancer cells . | [] |
This study was conducted to determine whether famotidine , a H2 antagonist , is effective in the treatment of acute urticaria and compare its effect with that of the H1 antagonist diphenhydramine . | [] |
On the other hand , a diphenylhydantoin-induced increase in the total number of specific benzodiazepine binding sites seems of minor importance since clonazepam ( with a high affinity for these sites ) and chlordiazepoxide ( with a low affinity ) were equipotent in the enhancement of the combined treatment efficacy . | [] |
A Phase II Randomized Study of Neoadjuvant Letrozole Plus Alpelisib for Hormone Receptor-Positive , Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer ( NEO-ORB ) . | [{'class': 'NEG', 'spans': ['Letrozole', 'Alpelisib'], 'is_context_needed': True}] |
Treatment with bromocriptine and pyridoxine showed no improvement . | [{'class': 'NEG', 'spans': ['bromocriptine', 'pyridoxine'], 'is_context_needed': False}] |
Bactericidal activity of trimethoprim alone and in combination with sulfamethoxazole on susceptible and resistant Escherichia coli K-12 . | [{'class': 'COMB', 'spans': ['trimethoprim', 'sulfamethoxazole'], 'is_context_needed': True}] |
New effective and well tolerated agents are urgently needed because of increasing resistance to antimalarials such as chloroquine and proguanil , and real and perceived intolerance to standard drugs such as mefloquine . | [] |
They were subsequently exposed to graded doses of cisplatin ( CP ) , etoposide ( VP-16 ) , Adriamycin ( ADR ) , cytarabine ( ara-C ) , cyclophosphamide ( CY ) , or camptothecin ( CAM ) . | [] |
In a phase II trial , patients with primary gastric cancer and clinical involvement of para-aortic nodes ( PAN ) were treated by neo-adjuvant chemotherapy with capecitabine and oxaliplatin combination , and responders were then submitted to gastrectomy with D2 lymphadenectomy . | [{'class': 'POS', 'spans': ['capecitabine', 'oxaliplatin'], 'is_context_needed': True}] |
More myelotoxicity is observed with palbociclib and ribociclib , but more gastrointestinal toxicity is observed with abemaciclib . | [] |
Intraoperative epidural bupivacaine , intraoperative intravenous fentanyl use , time to first analgesia request , postoperative visual analogue scale pain scores , tramadol requirements and side-effects were recorded for 72 hours . | [] |
Three eyes had both bevacizumab and ranibizumab ( 1.58 % ) . | [{'class': 'COMB', 'spans': ['bevacizumab', 'ranibizumab'], 'is_context_needed': True}] |
Newer treatment regimens , including etoposide , prednisone , vincristine , cyclophosphamide , doxorubicin , rituximab ( EPOCH-R ) , show promise for these patients . | [{'class': 'POS', 'spans': ['etoposide', 'prednisone', 'vincristine', 'cyclophosphamide', 'doxorubicin', 'rituximab'], 'is_context_needed': False}] |
In two groups of rats , propranolol or atropine were given before the venom administration . | [] |
Doxycycline and azithromycin were highly effective in restoring fertility . | [] |
The pupillary dilation caused by amantadine is not abolished by pretreatment with reserpine , or by combined pretreatment with reserpine and alpha-methyl-p-tyrosine , although the mydriasis is reduced by approximately 25 % . | [{'class': 'NEG', 'spans': ['amantadine', 'reserpine'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 2, 3], 'is_context_needed': True}] |
Rats were treated with curcumin for 23 days and etoposide was administered for the final 3 days of the experiment . | [{'class': 'POS', 'spans': ['curcumin', 'etoposide'], 'is_context_needed': True}] |
Combination Chemotherapy with Mitomycin C , Vinorelbine , and Cisplatin ( MVrP ) in Patients with Advanced Non-Small Cell Lung Cancer . | [{'class': 'POS', 'spans': ['Mitomycin', 'Vinorelbine', 'Cisplatin'], 'is_context_needed': True}] |
Bitches were also treated with amoxicillin ( 15 mg/kg body wt/48 h ) and/or gentamicin ( 4 mg/kg body wt/day ) administered as intramuscular ( i.m . ) injections . | [{'class': 'COMB', 'spans': ['amoxicillin', 'gentamicin'], 'is_context_needed': True}] |
So far , chloroquine , lopinavir , hydroxychloroquine , azithromycin , favipiravir , ribavirin , darunavir , remdesivir , and umifenovir have been tested in COVID-19 clinical trials . | [] |
Of the currently known pure antiandrogens , bicalutamide offers some advantages over flutamide as it possesses a much longer half-life , allowing a once daily regimen , and has advantages over nilutamide in terms of fewer adverse effects . | [] |
Fifty-seven patients with advanced measurable urothelial tract cancer , 52 of whom had an adequate trial , were treated weekly with 3 to 4 mg . per m.2 vinblastine and 30 to 40 mg . per m.2 methotrexate . | [{'class': 'POS', 'spans': ['vinblastine', 'methotrexate'], 'is_context_needed': True}] |
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