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Iohexol and iodixanol resulted in similarly marked increases in levels of inflammation and oxidative stress . | [] |
Sequential exposure of vinorelbine preceding paclitaxel or prolonged exposure to both agents concurrently needs to be tested clinically to determine whether the antitumor activity of this combination can be enhanced . | [{'class': 'POS', 'spans': ['vinorelbine', 'paclitaxel'], 'is_context_needed': True}] |
On the other hand we observed that topoisomerase II ( Top2 ) poisons ( doxorubicin and etoposide ) did not affect 1 day post fertilization embryo viability , however in cells isolated from Top2 drug treated embryos the formation of DNA cleavage complexes was observed by comet assay . | [] |
Favorable Response of Metastatic Hepatocellular Carcinoma to Treatment with Trans-arterial Radioembolization Followed by Sorafenib and Nivolumab . | [{'class': 'POS', 'spans': ['Sorafenib', 'Nivolumab'], 'is_context_needed': True}] |
In 23 adult patients , surgery , postoperative radiotherapy ( 60 Gy in 30 daily fractions within 6 weeks ) , and adjuvant modified chemotherapy ( procarbazine 60 mg/m(2 ) on Days 1 - 14 , lomustine 100 mg/m(2 ) on Day 1 , and vincristine 1.4 mg/m(2 ) [ maximum 2 mg ] on Days 1 and 8) were administered every 6 weeks for up to six cycles or until progression occurred . | [{'class': 'POS', 'spans': ['procarbazine', 'lomustine', 'vincristine'], 'is_context_needed': True}] |
In addition to prolonged survival , these exploratory HRQoL results show that nivolumab maintains baseline HRQoL levels to provide long-term quality of survival benefit , compared with dacarbazine in patients with advanced melanoma . | [] |
This phase 1 trial determined the safety , pharmacokinetics , and antitumor activity of LY3022855 in combination with durvalumab or tremelimumab in patients with advanced solid cancers who had received standard anti-cancer treatments . | [{'class': 'POS', 'spans': ['LY3022855', 'durvalumab'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': True}] |
Pharmacokinetic and pharmacodynamic interaction of vildagliptin and voglibose in Japanese patients with Type 2 diabetes . | [{'class': 'POS', 'spans': ['vildagliptin', 'voglibose'], 'is_context_needed': True}] |
CD133 + cells ( CD133 is marker of CSC in some tumors ) isolated from NBL , osteosarcoma and Ewing sarcoma cell lines are resistant to cisplatin , carboplatin , etoposide and doxorubicin than the CD133- ones . | [] |
The epidermal growth factor receptor ( EGFR ) inhibitors , gefitinib , erlotinib and afatinib ; the anaplastic lymphoma kinase ( ALK ) inhibitor , crizotinib ; and the anti-vascular endothelial growth factor receptor monoclonal antibody , bevacizumab , are already providing improved survival for patients with NSCLC . | [] |
Contrasting actions of acute or chronic paroxetine and fluvoxamine on morphine withdrawal-induced place conditioning . | [{'class': 'POS', 'spans': ['paroxetine', 'fluvoxamine'], 'is_context_needed': True}] |
Phase 3 data support the use of sunitinib , bevacizumab plus interferon-α and pazopanib for patients with low and intermediate risk of clear-cell renal cell carcinoma . | [{'class': 'POS', 'spans': ['sunitinib', 'bevacizumab', 'pazopanib', 'interferon-α'], 'is_context_needed': True}] |
This study is designed to find out the efficacy and toxicity of the combination of oxaliplatin and gemcitabine in the treatment of advanced non-small cell lung cancer ( NSCLC ) . | [{'class': 'POS', 'spans': ['oxaliplatin', 'gemcitabine'], 'is_context_needed': True}] |
All patients received 900 mg/m2 bolus of cyclophosphamide intravenously daily for 3 consecutive days with a concurrent infusion of 150 mg/m2 of paclitaxel over 72 h ( 50 mg/m2/d ) . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'paclitaxel'], 'is_context_needed': True}] |
Rituximab combined with a small dose of melphalan for a refractory follicular lymphoma patient . | [{'class': 'POS', 'spans': ['Rituximab', 'melphalan'], 'is_context_needed': True}] |
In this study , the intrinsic anti-bacterial activity of mefloquine and azithromycin was assessed in comparison to sulphadoxine-pyrimethamine against bacterial pathogens with clinical importance in pregnancy in a standard microdilution assay . | [] |
Pirfenidone has a beneficial effect on morphological changes in anti-GBM GN comparable with candesartan | [] |
Difluprednate versus prednisolone acetate for inflammation following cataract surgery in pediatric patients : a randomized safety and efficacy study . | [] |
Accumulated doses of cyclophosphamide , procarbazine , doxorubicin , mitoxantrone , and etoposide were 18,300 mg , 3000 mg , 580 mg , 100 mg , and 4150 mg , respectively , which had been administered for the treatment of NHL . | [{'class': 'COMB', 'spans': ['cyclophosphamide', 'procarbazine', 'doxorubicin', 'mitoxantrone', 'etoposide'], 'is_context_needed': True}] |
In newly diagnosed patients with MCL ineligible for intensive therapy and ASCT , the standard-of-care has generally been R-CHOP ( rituximab , cyclophosphamide , doxorubicin , vincristine , and prednisone ) , followed by rituximab , maintenance . | [{'class': 'POS', 'spans': ['rituximab', 'cyclophosphamide', 'doxorubicin', 'vincristine', 'prednisone', 'rituximab'], 'is_context_needed': False}] |
Here , we analyze the effects of the broad-spectrum HDAC inhibitors ( HDACi ) panobinostat and vorinostat on the transcriptional regulation of autophagy with respect to autophagy transcription factor activity ( Transcription factor EB-TFEB , forkhead boxO-FOXO ) and autophagic flux in neuroblastoma cells . | [] |
The postischemic decrease in total intensity and frequency index in EEG recovered rapidly when nitrendipine was pretreated , whereas the recovery of EEG parameters was not obtained by the nicardipine pretreatment . | [] |
The results indicate that BU and IPSA behave additively with verapamil and carbamazepine , which may be due to a common action on the same subtype of calcium channels . | [{'class': 'POS', 'spans': ['BU', 'IPSA', 'verapamil', 'carbamazepine'], 'is_context_needed': False}] |
The combination of docetaxel and trastuzumab is well tolerated and has clinically meaningful antitumor activity . | [{'class': 'POS', 'spans': ['docetaxel', 'trastuzumab'], 'is_context_needed': False}] |
Combined treatment using insulin-like growth factor-I with prednisolone or ursodeoxycholic acid additively increased bile flow volume . | [{'class': 'POS', 'spans': ['insulin-like growth factor-I', 'prednisolone'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
The AV3V-lesioned group of animals were characterized by an inability to excrete the excess sodium load and by a failure to increase secretion of both oxytocin and vasopressin into the general circulation in response to the salt-stimulus . | [] |
Patients received BBFC ( n = 193 ) , brinzolamide 1 % ( n = 192 ) , or brimonidine 0.2 % ( n = 175 ) BID . | [] |
Artemisinin ( ART ) is a sesquiterpene lactone extracted from Chinese herb qinghao , and artemether ( ARM ) , artesunate ( ARS ) and dihydroartemisinin ( DHA ) were synthesized derivatives of artemisinin , which also have anti-malarial and anti-cancer effects such as artemisinin . | [] |
Pharmacodynamic modeling of combined chemotherapeutic effects predicts synergistic activity of gemcitabine and trabectedin in pancreatic cancer cells . | [{'class': 'POS', 'spans': ['gemcitabine', 'trabectedin'], 'is_context_needed': True}] |
Conversely , down-regulation of cyclin E1 gene expression or inhibition of cyclin E1 by the cyclin-dependent kinase ( CDK ) inhibitors dinaciclib ( DIN ) or flavopiridol sensitized HCC cells to regorafenib and sorafenib by inducing apoptosis . | [{'class': 'POS', 'spans': ['flavopiridol', 'regorafenib'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': True}] |
Levofloxacin hemihydrate ( LEV ) and ambroxol HCl ( AMB ) are available for the treatment of upper and lower respiratory tract infections . | [] |
Cytarabine and etoposide intensification exceeded the acceptable toxic death rate of 10 % . | [{'class': 'NEG', 'spans': ['Cytarabine', 'etoposide'], 'is_context_needed': False}] |
After initiating warfarin plus lenvatinib , INR assays are necessary . | [{'class': 'COMB', 'spans': ['warfarin', 'lenvatinib'], 'is_context_needed': True}] |
Treatment with the DNA topoisomerase inhibitors etoposide , doxorubicin , and camptothecin , and with the alkylating agents cisplatin and melphalan , caused peroxide accumulation and apoptosis in U-937 human promonocytic cells . | [] |
We retrospectively analyzed 76 patients with LD SCLC who received combination cisplatin or carboplatin of etoposide or irinotecan . | [] |
MCF-7 cells which expressed a constitutively-activated Akt-1 gene [ ∆Akt-1(CA ) ] were more resistant to doxorubicin , etoposide and 4-OH-tamoxifen ( 4HT ) than cells lacking ∆Akt-1(CA ) . | [] |
that , in response to mitomycin C and doxorubicin , human hepatocellular carcinoma cells generate conflicting signals , mediated by cyclin E and p21WAF1/CIP1 , which respectively accelerates and represses cell cycle transition . | [] |
In the last years , the main topoisomerase I inhibitors ( TP1-I ) ( i.e. topotecan and irinotecan ) have been used in combination chemotherapy in non-small cell lung cancer . | [] |
Merimepodib ( MMPD ) is an orally administered , inosine monophosphate dehydrogenase inhibitor that has shown antiviral activity in nonresponders with chronic hepatitis C ( CHC ) when combined with pegylated interferon alfa 2a ( Peg-IFN-alfa-2a ) and ribavirin ( RBV ) . | [{'class': 'POS', 'spans': ['interferon alfa', 'ribavirin', 'Merimepodib'], 'is_context_needed': False}] |
Of the antibacterial agents examined , only carbenicillin and , to a lesser extent , gentamicin were active against the bacteria usually encountered whilst still permitting normal protoplast metabolism and regeneration . | [] |
Chemosensitization is one of the anti-tumor effects of E1A , increasing in vitro and in vivo sensitization of anti-cancer drugs , including cisplatin , gemcitabine , etoposide , doxorubicin , paclitaxel , and tumor necrosis factor-related apoptosis-inducing ligand and histone deacetylase inhibitors in different types of cancer cells . | [] |
A strong correlation was only found between the level of MRP3 expression and the IC(50 ) values of etoposide , doxorubicin and pirarubicin ( r = 0.86 - 0.98 , P<0.05 ) . | [] |
In addition to the typical cross-resistance to doxorubicin , daunorubicin , vincristine and etoposide , we observed a significant resistance of the C6,5 x 10(-7 ) Dox cell line to irradiation , which can not be explained by Pgp-expression . | [] |
[ Effects of endostatin and doxycycline on microcirculation patterns in melanoma and their relevant molecular mechanisms ] . | [{'class': 'COMB', 'spans': ['endostatin', 'doxycycline'], 'is_context_needed': True}] |
It is likely that optimal application of these agents will involve combinations of inhibitors and combinations of inhibitors and chemotherapy , potentially with a mammalian target of rapamycin inhibitor such as everolimus or temsirolimus . | [] |
Subsequent investigation of therapeutic responsiveness upon treatment with the current systemic gold standard EDP-M ( etoposide , doxorubicin , cisplatin and mitotane ) demonstrated maintenance of the clinically observed drug resistance for MUC-1 exclusively . | [{'class': 'POS', 'spans': ['etoposide', 'doxorubicin', 'cisplatin', 'mitotane'], 'is_context_needed': True}] |
Oxaliplatin is active in NSCLC , offers advantage in terms of toxicity , and shows synergism with gemcitabine . | [{'class': 'POS', 'spans': ['Oxaliplatin', 'gemcitabine'], 'is_context_needed': False}] |
A total of 34 patients with continuous measurements of FT levels and mCRPC status underwent therapy with docetaxel , abiraterone acetate , enzalutamide , cabozantinib , carboplatin or cabazitaxel . | [] |
Pharmacological interventions with a proton pump inhibitor ( PPI ) , H2 receptor antagonist ( H2RA ) , antacid , bismuth and sucralfate may have effects on both the prevention and treatment of upper gastrointestinal bleeding in infants . | [] |
Doxorubicin and lapatinib combination nanomedicine for treating resistant breast cancer . | [{'class': 'POS', 'spans': ['Doxorubicin', 'lapatinib'], 'is_context_needed': True}] |
The HIV protease inhibitor ritonavir , a strong CYP3A4 inhibitor , decreased first-pass metabolism of orally administered docetaxel . | [{'class': 'POS', 'spans': ['ritonavir', 'docetaxel'], 'is_context_needed': False}] |
Ramucirumab plus osimertinib demonstrated encouraging safety and antitumor activity in T790M-positive EGFR-mutant NSCLC . | [{'class': 'POS', 'spans': ['Ramucirumab', 'osimertinib'], 'is_context_needed': False}] |
The patient was complicated with hemophagocytic lymphohistiocytosis ( HLH ) and invasive aspergillosis ( IPA ) after re-induction treatment with FLAG-IDA following etoposide , cytarabine , and mitoxantrone . | [{'class': 'COMB', 'spans': ['etoposide', 'cytarabine', 'mitoxantrone'], 'is_context_needed': True}] |
On the other hand , cyclosporine and tacrolimus have a different impact on cardiovascular risk factors with tacrolimus having a better profile on arterial tension and lipid metabolism and cyclosporine on glucose metabolism . | [] |
Isoniazid , streptomycin , rifampin , and ethambutol were each tested at 3 concentrations by the radiometric method and the reference ( agar dilution ) method . | [] |
Pretreatment of the rats with methamphetamine ( MAP ) for 8 days prior to chronic haloperidol significantly enhanced the DOPAC and HVA increase produced by the challenge with haloperidol in both brain areas . | [{'class': 'POS', 'spans': ['methamphetamine', 'haloperidol'], 'is_context_needed': False}] |
The patients participated in three clinical trials that combined tumor vaccines with potential Treg-depleting agents : low-dose cyclophosphamide , anti-CD25 monoclonal antibody daclizumab , and the IL-2/diphtheria toxin fusion protein denileukin diftitox . | [] |
The quantity and composition of bacterial communities were altered by treatment with the five-antibiotic cocktail and by treatment with vancomycin and ampicillin . | [{'class': 'COMB', 'spans': ['vancomycin', 'ampicillin'], 'is_context_needed': True}] |
Successful treatment of an elderly Langerhans cell sarcoma patient by EPOCH ( etoposide , prednisone , vincristine , cyclophosphamide , and doxorubicin ) chemotherapy . | [{'class': 'POS', 'spans': ['etoposide', 'prednisone', 'vincristine', 'cyclophosphamide', 'doxorubicin'], 'is_context_needed': False}] |
Tremelimumab plus gemcitabine demonstrated a safety and tolerability profile , warranting further study in patients with metastatic pancreatic cancer . | [{'class': 'POS', 'spans': ['Tremelimumab', 'gemcitabine'], 'is_context_needed': True}] |
The sensitivity of a panel of short-term cultures derived from 22 malignant astrocytoma and four malignant oligodendroglioma was assessed to aziridinylbenzoquinone ( AZQ ) , etoposide and doxorubicin ( DOX ) using a [ (35)S ] methione uptake assay . | [] |
Longer progression-free survival ( PFS ) and overall survival ( OS ) were observed with T-DM1 compared with capecitabine plus lapatinib in all biomarker subgroups . | [{'class': 'COMB', 'spans': ['capecitabine', 'lapatinib'], 'is_context_needed': True}] |
Pharmacokinetics , Safety , and Antitumor Effect of Apalutamide with Abiraterone Acetate plus Prednisone in Metastatic Castration-Resistant Prostate Cancer : Phase Ib Study . | [{'class': 'POS', 'spans': ['Apalutamide', 'Abiraterone', 'Prednisone'], 'is_context_needed': True}] |
Combined treatment with nintedanib ( 200 mg/bid ) plus letrozole ( 2.5 mg/day ) effectively suppressed FGFR1 and aromatase activity , and these respective doses can be used as starting doses in any subsequent trials . | [{'class': 'POS', 'spans': ['nintedanib', 'letrozole'], 'is_context_needed': False}] |
A significant response to a combination of trastuzumab and vinorelbine in HER2-negative metastatic breast cancer with HER2 V777L mutation . | [{'class': 'POS', 'spans': ['trastuzumab', 'vinorelbine'], 'is_context_needed': False}] |
Patients ( n = 28 ) with metastatic solid tumors were randomized to receive pretreatment with Dex or GM-CSF or no pretreatment prior to courses 1 or 2 of carboplatin and ifosfamide . | [{'class': 'POS', 'spans': ['carboplatin', 'ifosfamide', 'Dex'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1, 3], 'is_context_needed': True}] |
After a thyroidectomy , she was treated with intravenous methylprednisolone pulse therapy and oral prednisolone followed by tacrolimus therapy . | [{'class': 'NEG', 'spans': ['methylprednisolone', 'prednisolone', 'tacrolimus'], 'is_context_needed': True}] |
The vinca alkaloid , vinorelbine , and the multi-targeted antifol , pemetrexed , were additive with imexon in both cell lines . | [{'class': 'POS', 'spans': ['vinorelbine', 'pemetrexed', 'imexon'], 'is_context_needed': False}] |
Supine blood pressures ( group means ) were 171/97 ( placebo ) , 147/85 ( enalapril ) , 154/84 ( atenolol ) and 144/78 ( enalapril plus atenolol ) ( S.E.M. + /- 2/+/- 1-ANOVA ) , and standing blood pressures were 170/105 ( placebo ) , 146/92 ( enalapril ) , 154/92 ( atenolol ) and 147/86 ( enalapril plus atenolol ) ( S.E.M. + /- 3/+/- 1 ) . | [{'class': 'POS', 'spans': ['enalapril', 'atenolol'], 'is_context_needed': False}] |
To evaluate the toxicity and activity of infusional fluorouracil ( FU ) , folinic acid ( FA ) , and oxaliplatin , administered every 2 weeks in patients with metastatic gastric cancer . | [{'class': 'POS', 'spans': ['fluorouracil', 'folinic acid', 'oxaliplatin'], 'is_context_needed': True}] |
Bevacizumab in combination with interferon alfa is now approved for treatment-naïve advanced renal cell carcinoma ( RCC ) in both the US and Europe . | [{'class': 'POS', 'spans': ['Bevacizumab', 'interferon alfa'], 'is_context_needed': False}] |
YM155 in combination with rituximab was tolerable with encouraging antitumor activity and durable responses in relapsed aggressive B-cell NHL patients . | [{'class': 'POS', 'spans': ['YM155', 'rituximab'], 'is_context_needed': False}] |
Both , droperidol and the new 5-HT3-antagonist ( e.g. dolasetron ) are effective drugs in the prevention of postoperative nausea and vomiting ( PONV ) . | [] |
Use of doxycycline or azithromycin had little effect on the likelihood of removal of the IUD within 90 days of insertion ( OR 1.05 ; 95 % CI 0.68 - 1.63 ) . | [] |
Similarly , a significant benefit in progression-free survival for carboplatin plus gemcitabine versus carboplatin monotherapy was seen in the Gynecologic Cancer InterGroup trial . | [{'class': 'POS', 'spans': ['carboplatin', 'gemcitabine'], 'is_context_needed': False}] |
We report a case series of 10 patients that were treated with betamethasone valerate foam ( 0.12 % ) in the morning and topical tazarotene cream ( 0.1 % ) in the evening for a total of 12 weeks or until plaques cleared . | [{'class': 'POS', 'spans': ['betamethasone', 'tazarotene'], 'is_context_needed': True}] |
Valsartan and sulfasalazine also reduced markers of oxidative stress after DSS administration . | [{'class': 'POS', 'spans': ['Valsartan', 'sulfasalazine'], 'is_context_needed': False}] |
Only two relapses have occurred in the cohort since withdrawal of Mitoxantrone , occurring in the two patients who had previously been treated with Glatiramer Acetate . | [] |
Metronomic 5-fluorouracil , oxaliplatin and irinotecan in colorectal cancer . | [{'class': 'COMB', 'spans': ['5-fluorouracil', 'oxaliplatin', 'irinotecan'], 'is_context_needed': True}] |
Several epidemiological , clinical and preclinical studies to date have supported the chemopreventive potentials of several targeted drug classes including non-steroidal anti-inflammatory drugs ( NSAIDs ) ( aspirin , naproxen , sulindac , celecoxib , and licofelone ) , statins and other natural agents-both individually , and in combinations . | [] |
Lenalidomide is an approved medication for relapsed mantle cell lymphoma in patients who received at least two lines of therapy , including bortezomib . | [] |
Combination of mefloquine and praziquantel gave better curative effects than praziquantel or mefloquine given alone . | [{'class': 'POS', 'spans': ['mefloquine', 'praziquantel'], 'is_context_needed': False}] |
The aim of this study was to evaluate whether trastuzumab modifies the pharmacokinetics of epirubicin and its metabolites . | [{'class': 'COMB', 'spans': ['trastuzumab', 'epirubicin'], 'is_context_needed': True}] |
Cardiac safety analysis of doxorubicin and cyclophosphamide followed by paclitaxel with or without trastuzumab in the North Central Cancer Treatment Group N9831 adjuvant breast cancer trial . | [{'class': 'POS', 'spans': ['doxorubicin', 'cyclophosphamide', 'paclitaxel'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [0, 1, 2, 3], 'is_context_needed': True}] |
Bupropion differentially alters the aversive , locomotor and rewarding properties of nicotine in CD-1 mice . | [{'class': 'POS', 'spans': ['Bupropion', 'nicotine'], 'is_context_needed': False}] |
We therefore aimed to determine the current antibiotic susceptibility of H. pylori to amoxicillin , clarithromycin , metronidazole , tetracycline and levofloxacin in Bangladesh . | [] |
With the exception of one Y. enterocolitica isolate which was resistant to tetracycline and streptomycin , the isolates were sensitive to the non-beta-lactam antibiotics . | [] |
Meropenem ( 84.5 % ) and vancomycin ( 100 % ) remain the most effective antimicrobial agents against Gram negative and Gram positive bacteria , respectively . | [] |
Troublesome coughing , as observed by the operator , was less frequent with glycopyrrolate ( control 51 % , atropine 42 % , glycopyrrolate 30 % ) , as was patient movement ( 40 % , 32 % , 19 % , respectively ) . | [] |
The first trial was a multicenter randomized phase III study of chemotherapy ( doxorubicin/cyclophosphamide or paclitaxel ) + /- trastuzumab , and the second was a multicenter phase II trial of vinorelbine + trastuzumab . | [{'class': 'COMB', 'spans': ['doxorubicin/cyclophosphamide', 'trastuzumab'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 2], 'is_context_needed': True}, {'class': 'COMB', 'spans': [3, 4], 'is_context_needed': True}] |
Peginterferon alfa-2a ( 40KD ) plus ribavirin has given an overall sustained virological response of 18 % in F3/F4 previous nonresponder US patients . | [{'class': 'POS', 'spans': ['Peginterferon alfa-2a', 'ribavirin'], 'is_context_needed': False}] |
Simultaneous determination of pyrimethamine and mefloquine in human plasma by high-performance liquid chromatography with ultraviolet detection . | [] |
We conducted a phase I and pharmacokinetic study with the erlotinib and celecoxib combination in patients with advanced premalignant lesions . | [{'class': 'POS', 'spans': ['erlotinib', 'celecoxib'], 'is_context_needed': True}] |
Out of 115 transplanted specimens 52 models were established of which 29 were characterized for response to docetaxel , cetuximab , methotrexate , carboplatin , 5-fluorouracil and everolimus . | [] |
Apart from progesterone , the enhancing effects of surfactants were better than those of non-surfactant MDR reversing agents such as verapamil , trifluoperazine and reserpine . | [] |
A549-Gem is cross-resistant to vincristine and etoposide , but not resistant to adriamycin , cisplatin , cytarabine and paclitaxel . | [] |
[ Efficacy of combination therapy of lamivudine and adefovir dipivoxyl for patients with hepatitis B-induced decompensated liver cirrhosis ] . | [{'class': 'POS', 'spans': ['lamivudine', 'adefovir'], 'is_context_needed': True}] |
The effervescent aspirin preparation is at least as effective as the combination of aspirin plus metoclopramide , but has fewer side effects . | [{'class': 'COMB', 'spans': ['aspirin', 'metoclopramide'], 'is_context_needed': True}] |
Several agents are now available in this setting , including neratinib , tucatinib , ado-trastuzumab emtansine , and trastuzumab deruxtecan . | [] |
This is an investigator-initiated , multicenter randomized controlled trial ( RCT ) designed to compare the combination treatment of adalimumab and methotrexate with adalimumab monotherapy in patients with psoriasis . | [{'class': 'COMB', 'spans': ['adalimumab', 'methotrexate'], 'is_context_needed': True}] |
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