bala1524/Drug_Combination_Extraction · Datasets at Hugging Face

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These results provide compelling preclinical rationale indicating lapatinib to be a potentially efficacious chemotherapeutic combination partner for irinotecan in the treatment of gastrointestinal carcinomas .	[{'class': 'POS', 'spans': ['lapatinib', 'irinotecan'], 'is_context_needed': False}]
In order to investigate the effects of a realistic pharmaceutical mixture on an ecosystem , a study utilizing 15 of 12,000 L aquatic microcosms treated with eight common pharmaceuticals ( atorvastatin , acetaminophen , caffeine , sulfamethoxazole , carbamazepine , levofloxacin , sertraline , and trimethoprim ) at total ( summed ) molar concentrations of 0 , 0.044 , 0.608 , 2.664 , and 24.538 micromol/L ( n = 3 ) was conducted .	[]
The enhancement characteristics in different portions of the liver during dynamic sequential bolus computed tomography ( CT ) with iodinated contrast material ( DSBCT ) were prospectively evaluated in 75 patients by using iothalamate meglumine , iopamidol , and iohexol ( 25 patients received each agent ) .	[]
Women with previously untreated bulky ( primary tumor > /= 4 cm ) stage IB or IIA non-small-cell carcinoma of the uterine cervix were randomly assigned to receive either cisplatin 50 mg/m(2 ) and vincristine 1 mg/m(2 ) for 1 day and bleomycin 25 mg/m(2 ) for 3 days for three cycles followed by radical hysterectomy ( NAC arm ) or receive primary pelvic radiotherapy only ( R/T arm ) .	[{'class': 'COMB', 'spans': ['cisplatin', 'vincristine', 'bleomycin'], 'is_context_needed': True}]
The purpose of this study was to evaluate the efficacy of long-term use of bupropion sustained release ( SR ) , the nicotine patch , and the combination of these 2 treatments in patients who initially failed treatment .	[{'class': 'POS', 'spans': ['bupropion', 'nicotine'], 'is_context_needed': True}]
Clinical and microbiologic cure rates for NGU were somewhat low and there was no significant difference between azithromycin and doxycycline .	[]
In the main study submitted for this application , a 2.4-month longer median overall survival time and a 30 % lower risk for death were observed for cabazitaxel , compared with mitoxantrone .	[]
Systemic chemotherapy with vincristine , actinomycin D , plus cyclophosphamide ( VAC therapy ) , and etoposide plus cisplatin ( EP therapy ) were made according to Intergroup Rhabdomyosarcoma Study (IRS)-IV Regimen 45 .	[{'class': 'NEG', 'spans': ['vincristine', 'actinomycin D', 'cyclophosphamide', 'etoposide', 'cisplatin'], 'is_context_needed': True}]
He was asymptomatic half a year after the rituximab with cyclophosphamide , vincristine , doxorubicin , methotrexate/ifosfamide , etoposide , and high-dose cytarabine protocol therapy ; the lymphoma is in remission .	[{'class': 'POS', 'spans': ['rituximab', 'cyclophosphamide', 'vincristine', 'doxorubicin', 'methotrexate/ifosfamide', 'etoposide', 'cytarabine'], 'is_context_needed': False}]
The RC0.1 and RC1 cells have high cross-resistance to CPT derivatives including SN-38 and topotecan , but are not cross-resistant to the non-top1 inhibitors etoposide , doxorubicin , and vincristine .	[]
To evaluate empiric nifuratel , amoxicillin , and bismuth triple therapy for H. pylori gastritis in childhood .	[{'class': 'POS', 'spans': ['nifuratel', 'amoxicillin', 'bismuth'], 'is_context_needed': True}]
The patient was treated in July 1998 with anthracycline , etoposide , and behenoyl cytarabine chemotherapy for AML ( French-American-British classification , M2 ; World Health Organization classification , AML with maturation ) and achieved complete remission .	[{'class': 'POS', 'spans': ['anthracycline', 'etoposide', 'behenoyl cytarabine'], 'is_context_needed': False}]
The risk increased when ASA was combined with clopidogrel , compared with aspirin alone ( OR , 1.86 ; 95 % CI , 1.49 - 2.31 ) , anticoagulants vs low doses of ASA alone ( OR , 1.93 ; 95 % CI , 1.42 - 2.61 ) , or in studies that included patients with a history of GI bleeding or of longer duration .	[{'class': 'NEG', 'spans': ['clopidogrel', 'ASA'], 'is_context_needed': False}]
Raloxifene , an anti-osteoporotic drug , is recently approved for prevention of breast cancer in postmenopausal women and thus the drug may be employed to combat the bony adverse effects of letrozole , another anticancer drug .	[{'class': 'POS', 'spans': ['Raloxifene', 'letrozole'], 'is_context_needed': True}]
In a previous trial , we found that adding the antiandrogen flutamide to leuprolide acetate ( a synthetic gonadotropin-releasing hormone that results in medical ablation of testicular function ) significantly improved survival as compared with that achieved with placebo plus leuprolide acetate .	[{'class': 'POS', 'spans': ['flutamide', 'leuprolide acetate'], 'is_context_needed': False}]
Contraceptives containing desogestrel or levonorgestrel have different effects on serum lipoproteins and post-heparin plasma lipase activities .	[{'class': 'COMB', 'spans': ['desogestrel', 'levonorgestrel'], 'is_context_needed': True}]
Gastric mucosa biopsy samples obtained from children who had undergone upper gastrointestinal endoscopy were cultured for H. pylori , and susceptibility to six antibiotics ( clarithromycin , amoxicillin , gentamicin , furazolidone , metronidazole , and levofloxacin ) was tested from 2012 - 2014 .	[]
Concentrations of guaifenesin , diphenhydramine , and chlorpheniramine detected in the heart blood were 27.4 , 8.8 , and 0.2 mg/L , respectively .	[{'class': 'NEG', 'spans': ['guaifenesin', 'diphenhydramine', 'chlorpheniramine'], 'is_context_needed': True}]
The standard chemotherapy for localized ESFT now comprises vincristine , actinomycin D , cyclophosphamide and doxorubicin ( VACD ) in Europe or vincristine , doxorubicin , cyclophosphamide , ifosfamide and etoposide ( VDC-IE ) in North America .	[{'class': 'COMB', 'spans': ['vincristine', 'actinomycin D', 'cyclophosphamide', 'doxorubicin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [4, 5, 6, 7, 8], 'is_context_needed': True}]
Ceftriaxone plus gentamicin or ceftriaxone alone for streptococcal endocarditis in Japanese patients as alternative first-line therapies .	[{'class': 'NEG', 'spans': ['Ceftriaxone', 'gentamicin'], 'is_context_needed': True}]
Combined therapy : what does acamprosate and naltrexone combination tell us ?	[{'class': 'POS', 'spans': ['acamprosate', 'naltrexone'], 'is_context_needed': True}]
Reflecting the role of STAT3 in inducing localized immune suppression , using both atovaquone and pyrimethamine resulted in the modulation of immunoregulatory genes predicted to enhance an immune response , including upregulation of ICOSLG ( Inducible T-Cell Costimulator Ligand or B7H2 ) .	[{'class': 'POS', 'spans': ['atovaquone', 'pyrimethamine'], 'is_context_needed': False}]
TVR can be used in combination with tenofovir , emtricitabine and raltegravir for patients with hemophilia .	[{'class': 'POS', 'spans': ['tenofovir', 'emtricitabine', 'raltegravir', 'TVR'], 'is_context_needed': False}]
Almost all the isolates were resistant to Ampicillin and Tobramycin ( 99.3 % each ) .	[]
Topical therapy with azithromycin and oral therapy with doxycycline relieved signs and symptoms and restored the lipid properties of the meibomian gland secretion toward normal .	[{'class': 'POS', 'spans': ['azithromycin', 'doxycycline'], 'is_context_needed': False}]
Pharmacy costs of cefazolin used as prophylaxis were more than twice the cost for cephapirin .	[]
PP-6 isolated from Tibetan Plateau could ferment raffinose , lactose , sorbitol , melibiose and sucrose , and LS-5 could ferment cottonseed sugar , laetrile , rhamnose , lactose , sorbitol , xylose , arabinose , melibiose and sucrose , but the same species of commercial strains could not use these sugars .	[]
Drug combinations , especially rapamycin + doxycycline may have promising anti-tumour effect in gliomas .	[{'class': 'POS', 'spans': ['rapamycin', 'doxycycline'], 'is_context_needed': False}]
Treatment with PUVA ( psoralen-ultraviolet-A ) combined with 40 - -80 mg prednisolone and then with chemotherapy [ COPP regimen ( cyclophosphamide , vincristine , procarbacine , prednisone ) , high-dosage methotrexate followed by citrovorum factor rescue ] was not successful .	[{'class': 'NEG', 'spans': ['prednisolone', 'cyclophosphamide', 'vincristine', 'prednisone', 'methotrexate', 'psoralen-ultraviolet-A', 'procarbacine', 'citrovorum'], 'is_context_needed': False}]
This population-based nonconcurrent cohort study of statewide California Cancer Registry data included all patients aged 40 to 85 years diagnosed with mCRC and treated with SC only or SC plus bevacizumab or cetuximab from January 1 , 2004 , through December 31 , 2014 .	[]
We evaluated a sequential treatment with Vinorelbine followed by Gemcitabine to determine its effect on survival and the toxicity in this patient population .	[{'class': 'POS', 'spans': ['Vinorelbine', 'Gemcitabine'], 'is_context_needed': True}]
Apoptosis in Hep2 cells treated with etoposide and colchicine .	[{'class': 'NEG', 'spans': ['etoposide', 'colchicine'], 'is_context_needed': True}]
The objective of this phase II study was to evaluate the efficacy and toxicity of carboplatin and weekly paclitaxel combination chemotherapy in previously untreated , advanced non-small cell lung cancer ( NSCLC ) .	[{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel'], 'is_context_needed': True}]
Therapy consisted of seven cycles of VCAP ( vincristine , cyclophosphamide , doxorubicin and prednisone ) , AMP ( doxorubicin , ranimustine and prednisone ) and VECP ( vindesine , etoposide , carboplatin and prednisone ) .	[{'class': 'POS', 'spans': ['vincristine', 'cyclophosphamide', 'doxorubicin', 'prednisone', 'doxorubicin', 'ranimustine', 'prednisone', 'etoposide', 'carboplatin', 'prednisone', 'vindesine'], 'is_context_needed': True}]
Indomethacin , naproxen and dexamethasone had no effect .	[]
In HER2-amplified cells , the combination of trastuzumab and lapatinib was evaluated using the median effects principal .	[{'class': 'POS', 'spans': ['trastuzumab', 'lapatinib'], 'is_context_needed': True}]
To assess the effects of photosensitizing drugs voriconazole and hydrochlorothiazide ( HCTZ ) on the enhancement of UV-induced inflammatory responses and UV-induced tumorigenesis , we utilized Xpa-knockout mice , which is DNA repair-deficient and more susceptible to UV-induced inflammation and tumor development than wild-type mice .	[]
Sorafenib monotherapy and combinations with taxanes , bevacizumab and ixabepilone showed inadequate efficacy , while efficacy results from combinations with gemcitabine and/or capecitabine and possibly tamoxifen were more promising .	[{'class': 'POS', 'spans': ['Sorafenib', 'gemcitabine'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 4], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 5], 'is_context_needed': False}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}]
This article reviews the pertinent studies regarding paclitaxel combined with cisplatin or carboplatin , discusses the remaining controversies surrounding how best to combine these agents , and provides opinions regarding the discordant outcomes noted in studies of the paclitaxel-platinum doublet .	[{'class': 'COMB', 'spans': ['paclitaxel', 'cisplatin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}]
The results indicate that neomycin only inhibits the growth of susceptible bacteria ( E. coli , Staph . aureus ) which , conversely , are poor lactitol fermenters .	[]
Hyperthermia could increase the sensitivity of SKOV3 to cis-platinum , carboplatin and oxaliplatin ( P < 0.05 ) .	[{'class': 'POS', 'spans': ['cis-platinum', 'Hyperthermia'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 3], 'is_context_needed': False}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': False}]
A prospective phase 2 trial of short-course ( SC ) radiation therapy ( RT ) with 25 Gy over 5 fractions , followed by 4 cycles of 5-fluorouracil , oxaliplatin , and leucovorin ( mFOLFOX6 ) before surgery was recently completed at our institution .	[{'class': 'POS', 'spans': ['5-fluorouracil', 'oxaliplatin', 'leucovorin'], 'is_context_needed': True}]
[ A case of advanced gastric cancer successfully treated with trastuzumab , capecitabine , and Cisplatin therapy followed by curative resection ] .	[{'class': 'POS', 'spans': ['trastuzumab', 'capecitabine', 'Cisplatin'], 'is_context_needed': True}]
Sulpiride plus hydroxyzine decrease tinnitus perception .	[{'class': 'POS', 'spans': ['Sulpiride', 'hydroxyzine'], 'is_context_needed': False}]
' Arimidex ' ( anastrozole ) versus tamoxifen as adjuvant therapy in postmenopausal women with early breast cancer -- efficacy overview .	[]
We gave 2 , 3 , 5 and 5 mg/day/body of recombinant tissue plasminogen activator ( tPA ) followed by heparin and prostaglandin E1 ( PGE1 ) effectively and without significant side effect on days 9 , 10 , 13 and 14 , respectively .	[{'class': 'POS', 'spans': ['tissue plasminogen activator', 'heparin', 'prostaglandin E1'], 'is_context_needed': False}]
Roxithromycin and clarithromycin , 14-membered ring macrolides , potentiate the antitumor activity of cytotoxic agents against mouse B16 melanoma cells .	[{'class': 'POS', 'spans': ['Roxithromycin', 'clarithromycin'], 'is_context_needed': False}]
The EVA regimen ( etoposide , vinblastine , doxorubicin ) is an attempt to substitute a known active agent , etoposide , for bleomycin and dacarbazine .	[{'class': 'POS', 'spans': ['etoposide', 'vinblastine', 'doxorubicin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 2, 4, 5], 'is_context_needed': True}]
The treatment of advanced non-small-cell lung cancer ( NSCLC is based on the combination of platin and one of the following agents : taxanes , gemcitabine , vinorelbine or irinotecan .	[]
Carvedilol and imatinib mesylate alone reduced cell number , BrDU-LI , cAMP levels and spheroid volume .	[{'class': 'POS', 'spans': ['Carvedilol', 'imatinib'], 'is_context_needed': False}]
The recommended phase II dose ( RP2D ) was cytarabine 10 mg bid days 1 - 10 and sorafenib 600 mg/day days 2 - 28 .	[{'class': 'POS', 'spans': ['cytarabine', 'sorafenib'], 'is_context_needed': True}]
We performed a single-arm phase II trial of panitumumab in patients with KRAS wild-type metastatic colorectal cancer that had progressed on prior cetuximab .	[{'class': 'NEG', 'spans': ['panitumumab', 'cetuximab'], 'is_context_needed': True}]
Two Phase 1 studies assessed effects of ABT-450 ( 150 mg coadministered with ritonavir 100 mg once daily ) , ombitasvir ( 25 mg once daily ) , and dasabuvir ( 400 mg twice daily ) on the pharmacokinetics , safety , and tolerability of a single dose of cyclosporine ( 30 mg ) or tacrolimus ( 2 mg ) in healthy volunteers ( N = 12 per study ) .	[{'class': 'POS', 'spans': ['ABT-450', 'ritonavir', 'ombitasvir', 'dasabuvir', 'cyclosporine'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1, 2, 3, 5], 'is_context_needed': True}]
In this study a new GC-MS method has been developed for direct analysis of five major steroid estrogens ( estrone , 17beta-estradiol , 17alpha-ethinylestradiol , dienestrol , and diethylstilbestrol ) in river sediments .	[]
A series of derivatives , like dihydroartemisinin , artesunate , artemether , artether , had the same core chemical structure , and sesquiterpene lactone containing peroxide bridge constitute the basic chemical structure .	[]
Antiplatelet therapy with dipyridamole , 100 mg q.i.d . , starting 2 days before surgery , followed by aspirin , 325 mg t.i.d . plus dipyridamole , 75 mg t.i.d . , 7 hours after surgery was assessed in the prevention of saphenous vein bypass graft occlusion .	[{'class': 'POS', 'spans': ['dipyridamole', 'aspirin', 'dipyridamole'], 'is_context_needed': True}]
Toxicity patterns following stepwise combinations of cyclophosphamide , methotrexate and fluorouracil .	[{'class': 'POS', 'spans': ['cyclophosphamide', 'methotrexate', 'fluorouracil'], 'is_context_needed': True}]
All patients were treated with the combination of lapatinib ( 1250 mg/day , continuously ) and capecitabine ( 2000 mg/m(2 ) on days 1 through 14 of a 21-day cycle ) .	[{'class': 'POS', 'spans': ['lapatinib', 'capecitabine'], 'is_context_needed': True}]
The present study explored the interaction between histaminergic and opioidergic systems at the level of the hippocampus in modulation of orofacial pain by intra-hippocampal microinjections of histamine , pyrilamine ( an antagonist of histamine H(1 ) receptors ) , ranitidine ( an antagonist of histamine H(2 ) receptors ) , morphine ( an opioid receptor agonist ) and naloxone ( an opioid receptor antagonist ) in separate and combined treatments .	[]
Effect of curcumin , a natural phytochemical in restoring doxorubicin sensitivity by targeting Aurora A was assessed furthermore .	[{'class': 'POS', 'spans': ['curcumin', 'doxorubicin'], 'is_context_needed': True}]
It is well established that several of the older AEDs ( carbamazepine , phenytoin and phenobarbital ) , are strong inducers of the hepatic cytochrome P450 ( CYP ) 3A4 enzyme system , and are associated with increased the risk of contraceptive failure .	[]
Our goals were to : establish the maximum-tolerated dose of olaparib tablets combined with metronomic carboplatin and paclitaxel in patients with relapsed high-grade serous ovarian cancer ; evaluate dose-limiting toxicities ; and evaluate efficacy at the maximum tolerated dose .	[{'class': 'POS', 'spans': ['olaparib', 'carboplatin', 'paclitaxel'], 'is_context_needed': True}]
Abiraterone acetate ( CB7630 ) , a pregnenolone analog , is an orally administered small molecule that irreversibly inhibits a rate-limiting enzyme in androgen biosynthesis , CYP17 , and blocks the synthesis of androgens in the testes , adrenal glands and prostate without causing adrenal insufficiency .	[]
There was no significant correlation between the response to ferrochloroquine and those to mefloquine , halofantrine , primaquine , atovaquone or artesunate .	[]
All patients in this study were treated with decitabine of 15 mg/m2 for 5 days and G-CSF for priming , in combination with cytarabine of 10-mg/m2 q12h for 7 days and aclarubicin of 10 mg/day for 4 days ( D-CAG ) .	[{'class': 'POS', 'spans': ['decitabine', 'cytarabine', 'aclarubicin'], 'is_context_needed': True}]
In chronic musculoskeletal conditions with assessments over 6 to 12 weeks , topical diclofenac and ketoprofen had limited efficacy in hand and knee osteoarthritis , as did topical high-concentration capsaicin in postherpetic neuralgia .	[]
Pertuzumab is the most recent agent approved by the US Food and Drug Administration in combination with trastuzumab and docetaxel for the treatment of patients with HER2(+ ) metastatic breast cancer who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease .	[{'class': 'POS', 'spans': ['Pertuzumab', 'trastuzumab', 'docetaxel'], 'is_context_needed': False}]
Safety and efficacy of sorafenib followed by regorafenib or lenvatinib in patients with hepatocellular carcinoma .	[{'class': 'COMB', 'spans': ['sorafenib', 'regorafenib'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}]
The combination of boceprevir or telaprevir with peginterferon-alfa and ribavirin for the treatment of patients infected with HCV genotype 1 has led to significantly increased rates of sustained virological response ( SVR ) in phase III trials .	[{'class': 'POS', 'spans': ['boceprevir', 'peginterferon-alfa', 'ribavirin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [1, 2, 3], 'is_context_needed': True}]
In contrast , the combination of plumbagin with AR antagonists , such as bicalutamide and enzalutamide , showed no improvement over AR antagonists alone .	[{'class': 'COMB', 'spans': ['bicalutamide', 'plumbagin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 2], 'is_context_needed': True}]
The B-cell lymphoma 2 ( BCL-2 ) inhibitor venetoclax has an emerging role in acute myeloid leukemia ( AML ) , with promising response rates in combination with hypomethylating agents or low-dose cytarabine in older patients .	[{'class': 'POS', 'spans': ['venetoclax', 'cytarabine'], 'is_context_needed': False}]
Combination chemotherapy with vincristine , bleomycin , and methotrexate for advanced head and neck cancers .	[{'class': 'NEG', 'spans': ['vincristine', 'bleomycin', 'methotrexate'], 'is_context_needed': True}]
Combination therapy with labetalol ( 400 mg/day ) and prazosin ( 6 mg/day ) was unsatisfactory , and the addition of long-acting nifedipine ( 40 mg/day ) produced a marked decrease in blood pressure .	[{'class': 'NEG', 'spans': ['labetalol', 'prazosin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 1, 2], 'is_context_needed': False}]
The monoclonal antibodies Ipilimumab , Pembrolizumab and Nivolumab , designed to interfere with T-cell inhibitory signals to activate immune responses against tumours , were originally approved as monotherapy .	[]
Recent studies have reported that the AI anastrozole has lower effectiveness than tamoxifen in women with high BMI .	[]
It was identified as C. lunata ( Wakker ) Boedijn var . aeria ( Batista , Lima and Vasconcelos ) Ellis ( IMI 253204 ) and its growth was better at 28 degrees C than at 37 degrees C. In vitro , the fungus was most sensitive to amphotericin B followed by miconazole nitrate , clotrimazole and triphenyltin isoselenocyanate 4-picoline which had the same activity .	[{'class': 'POS', 'spans': ['amphotericin', 'miconazole', 'clotrimazole', 'triphenyltin isoselenocyanate 4-picoline'], 'is_context_needed': False}]
Conclusions Everolimus plus mFOLFOX-6 + bevacizumab is tolerable and demonstrated preliminary efficacy for first-line mCRC .	[{'class': 'POS', 'spans': ['Everolimus', 'bevacizumab', 'mFOLFOX-6'], 'is_context_needed': False}]
Physician Utilization Patterns for VEGF-Inhibitor Drugs in the 2012 United States Medicare Population : Bevacizumab , Ranibizumab , and Aflibercept .	[]
Antimicrobials that can be used with confidence to treat NG infection currently in China include ceftriaxone and spectinomycin , but not penicillin , tetracycline , ciprofloxacin , and cefixime .	[]
A number of biologically targeted agents targeting the VEGF and mTOR signaling pathways have recently shown promise , with recent trials showing treatment with the VEGFR tyrosine kinase inhibitor sunitinib or the mTOR inhibitor everolimus improves progression-free survival in patients with advanced NET .	[]
We conducted a prospective phase II study to determine the response rate , toxicity , and survival rate of concurrent weekly paclitaxel , carboplatin , and hyperfractionated radiation therapy ( paclitaxel/carboplatin/HFX RT ) followed by 2 cycles of paclitaxel and carboplatin for locally advanced unresectable non-small cell lung cancer ( NSCLC ) .	[{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}]
A phase Ib study of pertuzumab , a recombinant humanised antibody to HER2 , and docetaxel in patients with advanced solid tumours .	[{'class': 'POS', 'spans': ['pertuzumab', 'docetaxel'], 'is_context_needed': True}]
These data suggest that vorinostat and doxorubicin may induce procoagulant activity in vessels through apoptosis of tumor cells and through phosphatidylserine exposure and/or tissue factor expression on vascular endothelial cells .	[{'class': 'NEG', 'spans': ['vorinostat', 'doxorubicin'], 'is_context_needed': True}]
Based on encouraging results of previous combination regimens , we used a combination of VM26 , ifosfamide , methyl GAG , mitoxantrone ( or adriamycin ) , high-dose ( HD ) methotrexate and HD Ara C to treat 18 patients with relapsed or refractory NHL .	[{'class': 'POS', 'spans': ['VM26', 'ifosfamide', 'methyl GAG ,', 'mitoxantrone', 'methotrexate', 'Ara C'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1, 2, 4, 5, 6], 'is_context_needed': True}]
We treated this patient with six cycles of CHOEP ( Cyclophosphamide , Doxorubicin , Vincristine , Etoposide , and Prednisone ) chemotherapy .	[{'class': 'POS', 'spans': ['Cyclophosphamide', 'Doxorubicin', 'Vincristine', 'Etoposide', 'Prednisone'], 'is_context_needed': True}]
One study evaluated gemcitabine with gemcitabine and pertuzumab .	[{'class': 'NEG', 'spans': ['gemcitabine', 'pertuzumab'], 'is_context_needed': True}]
Resistance could be abolished by structurally different chemosensitizers of P-glycoprotein function like verapamil and reserpine but not by the leukotriene receptor antagonist MK571 which is a modulator of the multidrug resistance-associated protein ( MRP ) .	[]
We conclude that the combination of thiotepa , 5FU , and leucovorin had significant myelotoxicity and do not recommend its routine use in the treatment of metastatic breast cancer .	[{'class': 'NEG', 'spans': ['thiotepa', '5FU', 'leucovorin'], 'is_context_needed': False}]
Forty-two patients with stage III to IV resectable HNSCC and nasopharyngeal tumors received induction chemotherapy with two courses of cisplatin ( 20 mg/m2/d continuous infusion [ CI ] ) , fluorouracil ( 800 mg/m2/d CI ) , and leucovorin ( 500 mg/m2/d CI ; PFL ) for 4 days followed by concurrent therapy with cisplatin ( 100 mg/m2/d on days 1 and 22 ) and approximately 70 Gy of external-beam radiotherapy .	[{'class': 'POS', 'spans': ['cisplatin', 'fluorouracil', 'leucovorin'], 'is_context_needed': True}]
The saliva is shown to inhibit human platelet aggregation induced by thrombin , collagen , adenosine diphosphate ( ADP ) , epinephrine , platelet activating factor ( 1-O-alkyl-2-acetyl-sn-3-glycerophophoryl choline [ PAF ] ) , and arachidonic acid .	[]
This clinical trial compared the efficacy of paclitaxel and vinorelbine in breast cancer neoadjuvant chemotherapy .	[]
Will a combination of l-leucine with low-dose metformin and sildenafil produce a novel synergistic interaction that reduces body weight ?	[{'class': 'POS', 'spans': ['l-leucine', 'metformin', 'sildenafil'], 'is_context_needed': True}]
Combinatory activity of linezolid and levofloxacin with antituberculosis drugs in Mycobacterium tuberculosis .	[{'class': 'POS', 'spans': ['linezolid', 'levofloxacin'], 'is_context_needed': True}]
Canadian clinical guidelines recommend the use of the combination of tamsulosin and dutasteride for men with moderate/severe symptoms associated with BPH and enlarged prostate volume .	[{'class': 'POS', 'spans': ['tamsulosin', 'dutasteride'], 'is_context_needed': False}]
The present study was designed to test the effects of chronic combined treatment with low doses of an angiotensin converting enzyme inhibitor ( perindopril ) and of the diuretic indapamide in spontaneously hypertensive rats ( SHR ) .	[{'class': 'POS', 'spans': ['perindopril', 'indapamide'], 'is_context_needed': True}]
A phase 3 trial of azacitidine versus a semi-intensive fludarabine and cytarabine schedule in older patients with untreated acute myeloid leukemia .	[{'class': 'NEG', 'spans': ['fludarabine', 'cytarabine'], 'is_context_needed': True}]
Five other treatments closely followed ( dabrafenib [ HR PFS : 0.30 ] , nivolumab plus ipilimumab [ HR PFS : 0.34 ] , vemurafenib [ HR PFS : 0.38 ] , nivolumab [ HR PFS : 0.42 ] and pembrolizumab [ HR PFS : 0.46 ] ) .	[{'class': 'POS', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': True}]
IGROV-1/APL resistant cell line shows the typical MDR phenotype : ( 1 ) increased expression of membrane-associated P-glycoprotein , ( 2 ) cross-resistance to drugs like etoposide , doxorubicin , vinblastine , vincristine , taxol , colchicin and the novel anticancer drug Yondelis ( ET-743 ) .	[]
Patients with newly diagnosed , locally advanced stage III or IV SCCHN received 4 weekly doses of carboplatin ( area under the curve , 1.5 ) and paclitaxel ( 45 mg/m(2 ) ) concurrently with concomitant boost radiation consisting of 72 grays in 42 fractions over 6 weeks ( every day for 18 days , twice a day for 12 days ) ( grading determined according to the TNM staging system ) .	[{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel'], 'is_context_needed': True}]
Phase 1b trial of docetaxel , prednisone , and pazopanib in men with metastatic castration-resistant prostate cancer .	[{'class': 'POS', 'spans': ['docetaxel', 'prednisone', 'pazopanib'], 'is_context_needed': True}]

These results provide compelling preclinical rationale indicating lapatinib to be a potentially efficacious chemotherapeutic combination partner for irinotecan in the treatment of gastrointestinal carcinomas .

[{'class': 'POS', 'spans': ['lapatinib', 'irinotecan'], 'is_context_needed': False}]

In order to investigate the effects of a realistic pharmaceutical mixture on an ecosystem , a study utilizing 15 of 12,000 L aquatic microcosms treated with eight common pharmaceuticals ( atorvastatin , acetaminophen , caffeine , sulfamethoxazole , carbamazepine , levofloxacin , sertraline , and trimethoprim ) at total ( summed ) molar concentrations of 0 , 0.044 , 0.608 , 2.664 , and 24.538 micromol/L ( n = 3 ) was conducted .

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The enhancement characteristics in different portions of the liver during dynamic sequential bolus computed tomography ( CT ) with iodinated contrast material ( DSBCT ) were prospectively evaluated in 75 patients by using iothalamate meglumine , iopamidol , and iohexol ( 25 patients received each agent ) .

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Women with previously untreated bulky ( primary tumor > /= 4 cm ) stage IB or IIA non-small-cell carcinoma of the uterine cervix were randomly assigned to receive either cisplatin 50 mg/m(2 ) and vincristine 1 mg/m(2 ) for 1 day and bleomycin 25 mg/m(2 ) for 3 days for three cycles followed by radical hysterectomy ( NAC arm ) or receive primary pelvic radiotherapy only ( R/T arm ) .

[{'class': 'COMB', 'spans': ['cisplatin', 'vincristine', 'bleomycin'], 'is_context_needed': True}]

The purpose of this study was to evaluate the efficacy of long-term use of bupropion sustained release ( SR ) , the nicotine patch , and the combination of these 2 treatments in patients who initially failed treatment .

[{'class': 'POS', 'spans': ['bupropion', 'nicotine'], 'is_context_needed': True}]

Clinical and microbiologic cure rates for NGU were somewhat low and there was no significant difference between azithromycin and doxycycline .

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In the main study submitted for this application , a 2.4-month longer median overall survival time and a 30 % lower risk for death were observed for cabazitaxel , compared with mitoxantrone .

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Systemic chemotherapy with vincristine , actinomycin D , plus cyclophosphamide ( VAC therapy ) , and etoposide plus cisplatin ( EP therapy ) were made according to Intergroup Rhabdomyosarcoma Study (IRS)-IV Regimen 45 .

[{'class': 'NEG', 'spans': ['vincristine', 'actinomycin D', 'cyclophosphamide', 'etoposide', 'cisplatin'], 'is_context_needed': True}]

He was asymptomatic half a year after the rituximab with cyclophosphamide , vincristine , doxorubicin , methotrexate/ifosfamide , etoposide , and high-dose cytarabine protocol therapy ; the lymphoma is in remission .

[{'class': 'POS', 'spans': ['rituximab', 'cyclophosphamide', 'vincristine', 'doxorubicin', 'methotrexate/ifosfamide', 'etoposide', 'cytarabine'], 'is_context_needed': False}]

The RC0.1 and RC1 cells have high cross-resistance to CPT derivatives including SN-38 and topotecan , but are not cross-resistant to the non-top1 inhibitors etoposide , doxorubicin , and vincristine .

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To evaluate empiric nifuratel , amoxicillin , and bismuth triple therapy for H. pylori gastritis in childhood .

[{'class': 'POS', 'spans': ['nifuratel', 'amoxicillin', 'bismuth'], 'is_context_needed': True}]

The patient was treated in July 1998 with anthracycline , etoposide , and behenoyl cytarabine chemotherapy for AML ( French-American-British classification , M2 ; World Health Organization classification , AML with maturation ) and achieved complete remission .

[{'class': 'POS', 'spans': ['anthracycline', 'etoposide', 'behenoyl cytarabine'], 'is_context_needed': False}]

The risk increased when ASA was combined with clopidogrel , compared with aspirin alone ( OR , 1.86 ; 95 % CI , 1.49 - 2.31 ) , anticoagulants vs low doses of ASA alone ( OR , 1.93 ; 95 % CI , 1.42 - 2.61 ) , or in studies that included patients with a history of GI bleeding or of longer duration .

[{'class': 'NEG', 'spans': ['clopidogrel', 'ASA'], 'is_context_needed': False}]

Raloxifene , an anti-osteoporotic drug , is recently approved for prevention of breast cancer in postmenopausal women and thus the drug may be employed to combat the bony adverse effects of letrozole , another anticancer drug .

[{'class': 'POS', 'spans': ['Raloxifene', 'letrozole'], 'is_context_needed': True}]

In a previous trial , we found that adding the antiandrogen flutamide to leuprolide acetate ( a synthetic gonadotropin-releasing hormone that results in medical ablation of testicular function ) significantly improved survival as compared with that achieved with placebo plus leuprolide acetate .

[{'class': 'POS', 'spans': ['flutamide', 'leuprolide acetate'], 'is_context_needed': False}]

Contraceptives containing desogestrel or levonorgestrel have different effects on serum lipoproteins and post-heparin plasma lipase activities .

[{'class': 'COMB', 'spans': ['desogestrel', 'levonorgestrel'], 'is_context_needed': True}]

Gastric mucosa biopsy samples obtained from children who had undergone upper gastrointestinal endoscopy were cultured for H. pylori , and susceptibility to six antibiotics ( clarithromycin , amoxicillin , gentamicin , furazolidone , metronidazole , and levofloxacin ) was tested from 2012 - 2014 .

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Concentrations of guaifenesin , diphenhydramine , and chlorpheniramine detected in the heart blood were 27.4 , 8.8 , and 0.2 mg/L , respectively .

[{'class': 'NEG', 'spans': ['guaifenesin', 'diphenhydramine', 'chlorpheniramine'], 'is_context_needed': True}]

The standard chemotherapy for localized ESFT now comprises vincristine , actinomycin D , cyclophosphamide and doxorubicin ( VACD ) in Europe or vincristine , doxorubicin , cyclophosphamide , ifosfamide and etoposide ( VDC-IE ) in North America .

[{'class': 'COMB', 'spans': ['vincristine', 'actinomycin D', 'cyclophosphamide', 'doxorubicin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [4, 5, 6, 7, 8], 'is_context_needed': True}]

Ceftriaxone plus gentamicin or ceftriaxone alone for streptococcal endocarditis in Japanese patients as alternative first-line therapies .

[{'class': 'NEG', 'spans': ['Ceftriaxone', 'gentamicin'], 'is_context_needed': True}]

Combined therapy : what does acamprosate and naltrexone combination tell us ?

[{'class': 'POS', 'spans': ['acamprosate', 'naltrexone'], 'is_context_needed': True}]

Reflecting the role of STAT3 in inducing localized immune suppression , using both atovaquone and pyrimethamine resulted in the modulation of immunoregulatory genes predicted to enhance an immune response , including upregulation of ICOSLG ( Inducible T-Cell Costimulator Ligand or B7H2 ) .

[{'class': 'POS', 'spans': ['atovaquone', 'pyrimethamine'], 'is_context_needed': False}]

TVR can be used in combination with tenofovir , emtricitabine and raltegravir for patients with hemophilia .

[{'class': 'POS', 'spans': ['tenofovir', 'emtricitabine', 'raltegravir', 'TVR'], 'is_context_needed': False}]

Almost all the isolates were resistant to Ampicillin and Tobramycin ( 99.3 % each ) .

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Topical therapy with azithromycin and oral therapy with doxycycline relieved signs and symptoms and restored the lipid properties of the meibomian gland secretion toward normal .

[{'class': 'POS', 'spans': ['azithromycin', 'doxycycline'], 'is_context_needed': False}]

Pharmacy costs of cefazolin used as prophylaxis were more than twice the cost for cephapirin .

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PP-6 isolated from Tibetan Plateau could ferment raffinose , lactose , sorbitol , melibiose and sucrose , and LS-5 could ferment cottonseed sugar , laetrile , rhamnose , lactose , sorbitol , xylose , arabinose , melibiose and sucrose , but the same species of commercial strains could not use these sugars .

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Drug combinations , especially rapamycin + doxycycline may have promising anti-tumour effect in gliomas .

[{'class': 'POS', 'spans': ['rapamycin', 'doxycycline'], 'is_context_needed': False}]

Treatment with PUVA ( psoralen-ultraviolet-A ) combined with 40 - -80 mg prednisolone and then with chemotherapy [ COPP regimen ( cyclophosphamide , vincristine , procarbacine , prednisone ) , high-dosage methotrexate followed by citrovorum factor rescue ] was not successful .

[{'class': 'NEG', 'spans': ['prednisolone', 'cyclophosphamide', 'vincristine', 'prednisone', 'methotrexate', 'psoralen-ultraviolet-A', 'procarbacine', 'citrovorum'], 'is_context_needed': False}]

This population-based nonconcurrent cohort study of statewide California Cancer Registry data included all patients aged 40 to 85 years diagnosed with mCRC and treated with SC only or SC plus bevacizumab or cetuximab from January 1 , 2004 , through December 31 , 2014 .

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We evaluated a sequential treatment with Vinorelbine followed by Gemcitabine to determine its effect on survival and the toxicity in this patient population .

[{'class': 'POS', 'spans': ['Vinorelbine', 'Gemcitabine'], 'is_context_needed': True}]

Apoptosis in Hep2 cells treated with etoposide and colchicine .

[{'class': 'NEG', 'spans': ['etoposide', 'colchicine'], 'is_context_needed': True}]

The objective of this phase II study was to evaluate the efficacy and toxicity of carboplatin and weekly paclitaxel combination chemotherapy in previously untreated , advanced non-small cell lung cancer ( NSCLC ) .

[{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel'], 'is_context_needed': True}]

Therapy consisted of seven cycles of VCAP ( vincristine , cyclophosphamide , doxorubicin and prednisone ) , AMP ( doxorubicin , ranimustine and prednisone ) and VECP ( vindesine , etoposide , carboplatin and prednisone ) .

[{'class': 'POS', 'spans': ['vincristine', 'cyclophosphamide', 'doxorubicin', 'prednisone', 'doxorubicin', 'ranimustine', 'prednisone', 'etoposide', 'carboplatin', 'prednisone', 'vindesine'], 'is_context_needed': True}]

Indomethacin , naproxen and dexamethasone had no effect .

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In HER2-amplified cells , the combination of trastuzumab and lapatinib was evaluated using the median effects principal .

[{'class': 'POS', 'spans': ['trastuzumab', 'lapatinib'], 'is_context_needed': True}]

To assess the effects of photosensitizing drugs voriconazole and hydrochlorothiazide ( HCTZ ) on the enhancement of UV-induced inflammatory responses and UV-induced tumorigenesis , we utilized Xpa-knockout mice , which is DNA repair-deficient and more susceptible to UV-induced inflammation and tumor development than wild-type mice .

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Sorafenib monotherapy and combinations with taxanes , bevacizumab and ixabepilone showed inadequate efficacy , while efficacy results from combinations with gemcitabine and/or capecitabine and possibly tamoxifen were more promising .

[{'class': 'POS', 'spans': ['Sorafenib', 'gemcitabine'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 4], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 5], 'is_context_needed': False}, {'class': 'COMB', 'spans': [0, 1], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}]

This article reviews the pertinent studies regarding paclitaxel combined with cisplatin or carboplatin , discusses the remaining controversies surrounding how best to combine these agents , and provides opinions regarding the discordant outcomes noted in studies of the paclitaxel-platinum doublet .

[{'class': 'COMB', 'spans': ['paclitaxel', 'cisplatin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}]

The results indicate that neomycin only inhibits the growth of susceptible bacteria ( E. coli , Staph . aureus ) which , conversely , are poor lactitol fermenters .

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Hyperthermia could increase the sensitivity of SKOV3 to cis-platinum , carboplatin and oxaliplatin ( P < 0.05 ) .

[{'class': 'POS', 'spans': ['cis-platinum', 'Hyperthermia'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 3], 'is_context_needed': False}, {'class': 'POS', 'spans': [2, 3], 'is_context_needed': False}]

A prospective phase 2 trial of short-course ( SC ) radiation therapy ( RT ) with 25 Gy over 5 fractions , followed by 4 cycles of 5-fluorouracil , oxaliplatin , and leucovorin ( mFOLFOX6 ) before surgery was recently completed at our institution .

[{'class': 'POS', 'spans': ['5-fluorouracil', 'oxaliplatin', 'leucovorin'], 'is_context_needed': True}]

[ A case of advanced gastric cancer successfully treated with trastuzumab , capecitabine , and Cisplatin therapy followed by curative resection ] .

[{'class': 'POS', 'spans': ['trastuzumab', 'capecitabine', 'Cisplatin'], 'is_context_needed': True}]

Sulpiride plus hydroxyzine decrease tinnitus perception .

[{'class': 'POS', 'spans': ['Sulpiride', 'hydroxyzine'], 'is_context_needed': False}]

' Arimidex ' ( anastrozole ) versus tamoxifen as adjuvant therapy in postmenopausal women with early breast cancer -- efficacy overview .

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We gave 2 , 3 , 5 and 5 mg/day/body of recombinant tissue plasminogen activator ( tPA ) followed by heparin and prostaglandin E1 ( PGE1 ) effectively and without significant side effect on days 9 , 10 , 13 and 14 , respectively .

[{'class': 'POS', 'spans': ['tissue plasminogen activator', 'heparin', 'prostaglandin E1'], 'is_context_needed': False}]

Roxithromycin and clarithromycin , 14-membered ring macrolides , potentiate the antitumor activity of cytotoxic agents against mouse B16 melanoma cells .

[{'class': 'POS', 'spans': ['Roxithromycin', 'clarithromycin'], 'is_context_needed': False}]

The EVA regimen ( etoposide , vinblastine , doxorubicin ) is an attempt to substitute a known active agent , etoposide , for bleomycin and dacarbazine .

[{'class': 'POS', 'spans': ['etoposide', 'vinblastine', 'doxorubicin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 2, 4, 5], 'is_context_needed': True}]

The treatment of advanced non-small-cell lung cancer ( NSCLC is based on the combination of platin and one of the following agents : taxanes , gemcitabine , vinorelbine or irinotecan .

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Carvedilol and imatinib mesylate alone reduced cell number , BrDU-LI , cAMP levels and spheroid volume .

[{'class': 'POS', 'spans': ['Carvedilol', 'imatinib'], 'is_context_needed': False}]

The recommended phase II dose ( RP2D ) was cytarabine 10 mg bid days 1 - 10 and sorafenib 600 mg/day days 2 - 28 .

[{'class': 'POS', 'spans': ['cytarabine', 'sorafenib'], 'is_context_needed': True}]

We performed a single-arm phase II trial of panitumumab in patients with KRAS wild-type metastatic colorectal cancer that had progressed on prior cetuximab .

[{'class': 'NEG', 'spans': ['panitumumab', 'cetuximab'], 'is_context_needed': True}]

Two Phase 1 studies assessed effects of ABT-450 ( 150 mg coadministered with ritonavir 100 mg once daily ) , ombitasvir ( 25 mg once daily ) , and dasabuvir ( 400 mg twice daily ) on the pharmacokinetics , safety , and tolerability of a single dose of cyclosporine ( 30 mg ) or tacrolimus ( 2 mg ) in healthy volunteers ( N = 12 per study ) .

[{'class': 'POS', 'spans': ['ABT-450', 'ritonavir', 'ombitasvir', 'dasabuvir', 'cyclosporine'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1, 2, 3, 5], 'is_context_needed': True}]

In this study a new GC-MS method has been developed for direct analysis of five major steroid estrogens ( estrone , 17beta-estradiol , 17alpha-ethinylestradiol , dienestrol , and diethylstilbestrol ) in river sediments .

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A series of derivatives , like dihydroartemisinin , artesunate , artemether , artether , had the same core chemical structure , and sesquiterpene lactone containing peroxide bridge constitute the basic chemical structure .

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Antiplatelet therapy with dipyridamole , 100 mg q.i.d . , starting 2 days before surgery , followed by aspirin , 325 mg t.i.d . plus dipyridamole , 75 mg t.i.d . , 7 hours after surgery was assessed in the prevention of saphenous vein bypass graft occlusion .

[{'class': 'POS', 'spans': ['dipyridamole', 'aspirin', 'dipyridamole'], 'is_context_needed': True}]

Toxicity patterns following stepwise combinations of cyclophosphamide , methotrexate and fluorouracil .

[{'class': 'POS', 'spans': ['cyclophosphamide', 'methotrexate', 'fluorouracil'], 'is_context_needed': True}]

All patients were treated with the combination of lapatinib ( 1250 mg/day , continuously ) and capecitabine ( 2000 mg/m(2 ) on days 1 through 14 of a 21-day cycle ) .

[{'class': 'POS', 'spans': ['lapatinib', 'capecitabine'], 'is_context_needed': True}]

The present study explored the interaction between histaminergic and opioidergic systems at the level of the hippocampus in modulation of orofacial pain by intra-hippocampal microinjections of histamine , pyrilamine ( an antagonist of histamine H(1 ) receptors ) , ranitidine ( an antagonist of histamine H(2 ) receptors ) , morphine ( an opioid receptor agonist ) and naloxone ( an opioid receptor antagonist ) in separate and combined treatments .

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Effect of curcumin , a natural phytochemical in restoring doxorubicin sensitivity by targeting Aurora A was assessed furthermore .

[{'class': 'POS', 'spans': ['curcumin', 'doxorubicin'], 'is_context_needed': True}]

It is well established that several of the older AEDs ( carbamazepine , phenytoin and phenobarbital ) , are strong inducers of the hepatic cytochrome P450 ( CYP ) 3A4 enzyme system , and are associated with increased the risk of contraceptive failure .

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Our goals were to : establish the maximum-tolerated dose of olaparib tablets combined with metronomic carboplatin and paclitaxel in patients with relapsed high-grade serous ovarian cancer ; evaluate dose-limiting toxicities ; and evaluate efficacy at the maximum tolerated dose .

[{'class': 'POS', 'spans': ['olaparib', 'carboplatin', 'paclitaxel'], 'is_context_needed': True}]

Abiraterone acetate ( CB7630 ) , a pregnenolone analog , is an orally administered small molecule that irreversibly inhibits a rate-limiting enzyme in androgen biosynthesis , CYP17 , and blocks the synthesis of androgens in the testes , adrenal glands and prostate without causing adrenal insufficiency .

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There was no significant correlation between the response to ferrochloroquine and those to mefloquine , halofantrine , primaquine , atovaquone or artesunate .

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All patients in this study were treated with decitabine of 15 mg/m2 for 5 days and G-CSF for priming , in combination with cytarabine of 10-mg/m2 q12h for 7 days and aclarubicin of 10 mg/day for 4 days ( D-CAG ) .

[{'class': 'POS', 'spans': ['decitabine', 'cytarabine', 'aclarubicin'], 'is_context_needed': True}]

In chronic musculoskeletal conditions with assessments over 6 to 12 weeks , topical diclofenac and ketoprofen had limited efficacy in hand and knee osteoarthritis , as did topical high-concentration capsaicin in postherpetic neuralgia .

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Pertuzumab is the most recent agent approved by the US Food and Drug Administration in combination with trastuzumab and docetaxel for the treatment of patients with HER2(+ ) metastatic breast cancer who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease .

[{'class': 'POS', 'spans': ['Pertuzumab', 'trastuzumab', 'docetaxel'], 'is_context_needed': False}]

Safety and efficacy of sorafenib followed by regorafenib or lenvatinib in patients with hepatocellular carcinoma .

[{'class': 'COMB', 'spans': ['sorafenib', 'regorafenib'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}]

The combination of boceprevir or telaprevir with peginterferon-alfa and ribavirin for the treatment of patients infected with HCV genotype 1 has led to significantly increased rates of sustained virological response ( SVR ) in phase III trials .

[{'class': 'POS', 'spans': ['boceprevir', 'peginterferon-alfa', 'ribavirin'], 'is_context_needed': True}, {'class': 'POS', 'spans': [1, 2, 3], 'is_context_needed': True}]

In contrast , the combination of plumbagin with AR antagonists , such as bicalutamide and enzalutamide , showed no improvement over AR antagonists alone .

[{'class': 'COMB', 'spans': ['bicalutamide', 'plumbagin'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [1, 2], 'is_context_needed': True}]

The B-cell lymphoma 2 ( BCL-2 ) inhibitor venetoclax has an emerging role in acute myeloid leukemia ( AML ) , with promising response rates in combination with hypomethylating agents or low-dose cytarabine in older patients .

[{'class': 'POS', 'spans': ['venetoclax', 'cytarabine'], 'is_context_needed': False}]

Combination chemotherapy with vincristine , bleomycin , and methotrexate for advanced head and neck cancers .

[{'class': 'NEG', 'spans': ['vincristine', 'bleomycin', 'methotrexate'], 'is_context_needed': True}]

Combination therapy with labetalol ( 400 mg/day ) and prazosin ( 6 mg/day ) was unsatisfactory , and the addition of long-acting nifedipine ( 40 mg/day ) produced a marked decrease in blood pressure .

[{'class': 'NEG', 'spans': ['labetalol', 'prazosin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 1, 2], 'is_context_needed': False}]

The monoclonal antibodies Ipilimumab , Pembrolizumab and Nivolumab , designed to interfere with T-cell inhibitory signals to activate immune responses against tumours , were originally approved as monotherapy .

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Recent studies have reported that the AI anastrozole has lower effectiveness than tamoxifen in women with high BMI .

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It was identified as C. lunata ( Wakker ) Boedijn var . aeria ( Batista , Lima and Vasconcelos ) Ellis ( IMI 253204 ) and its growth was better at 28 degrees C than at 37 degrees C. In vitro , the fungus was most sensitive to amphotericin B followed by miconazole nitrate , clotrimazole and triphenyltin isoselenocyanate 4-picoline which had the same activity .

[{'class': 'POS', 'spans': ['amphotericin', 'miconazole', 'clotrimazole', 'triphenyltin isoselenocyanate 4-picoline'], 'is_context_needed': False}]

Conclusions Everolimus plus mFOLFOX-6 + bevacizumab is tolerable and demonstrated preliminary efficacy for first-line mCRC .

[{'class': 'POS', 'spans': ['Everolimus', 'bevacizumab', 'mFOLFOX-6'], 'is_context_needed': False}]

Physician Utilization Patterns for VEGF-Inhibitor Drugs in the 2012 United States Medicare Population : Bevacizumab , Ranibizumab , and Aflibercept .

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Antimicrobials that can be used with confidence to treat NG infection currently in China include ceftriaxone and spectinomycin , but not penicillin , tetracycline , ciprofloxacin , and cefixime .

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A number of biologically targeted agents targeting the VEGF and mTOR signaling pathways have recently shown promise , with recent trials showing treatment with the VEGFR tyrosine kinase inhibitor sunitinib or the mTOR inhibitor everolimus improves progression-free survival in patients with advanced NET .

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We conducted a prospective phase II study to determine the response rate , toxicity , and survival rate of concurrent weekly paclitaxel , carboplatin , and hyperfractionated radiation therapy ( paclitaxel/carboplatin/HFX RT ) followed by 2 cycles of paclitaxel and carboplatin for locally advanced unresectable non-small cell lung cancer ( NSCLC ) .

[{'class': 'POS', 'spans': ['paclitaxel', 'carboplatin'], 'is_context_needed': True}]

A phase Ib study of pertuzumab , a recombinant humanised antibody to HER2 , and docetaxel in patients with advanced solid tumours .

[{'class': 'POS', 'spans': ['pertuzumab', 'docetaxel'], 'is_context_needed': True}]

These data suggest that vorinostat and doxorubicin may induce procoagulant activity in vessels through apoptosis of tumor cells and through phosphatidylserine exposure and/or tissue factor expression on vascular endothelial cells .

[{'class': 'NEG', 'spans': ['vorinostat', 'doxorubicin'], 'is_context_needed': True}]

Based on encouraging results of previous combination regimens , we used a combination of VM26 , ifosfamide , methyl GAG , mitoxantrone ( or adriamycin ) , high-dose ( HD ) methotrexate and HD Ara C to treat 18 patients with relapsed or refractory NHL .

[{'class': 'POS', 'spans': ['VM26', 'ifosfamide', 'methyl GAG ,', 'mitoxantrone', 'methotrexate', 'Ara C'], 'is_context_needed': True}, {'class': 'POS', 'spans': [0, 1, 2, 4, 5, 6], 'is_context_needed': True}]

We treated this patient with six cycles of CHOEP ( Cyclophosphamide , Doxorubicin , Vincristine , Etoposide , and Prednisone ) chemotherapy .

[{'class': 'POS', 'spans': ['Cyclophosphamide', 'Doxorubicin', 'Vincristine', 'Etoposide', 'Prednisone'], 'is_context_needed': True}]

One study evaluated gemcitabine with gemcitabine and pertuzumab .

[{'class': 'NEG', 'spans': ['gemcitabine', 'pertuzumab'], 'is_context_needed': True}]

Resistance could be abolished by structurally different chemosensitizers of P-glycoprotein function like verapamil and reserpine but not by the leukotriene receptor antagonist MK571 which is a modulator of the multidrug resistance-associated protein ( MRP ) .

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We conclude that the combination of thiotepa , 5FU , and leucovorin had significant myelotoxicity and do not recommend its routine use in the treatment of metastatic breast cancer .

[{'class': 'NEG', 'spans': ['thiotepa', '5FU', 'leucovorin'], 'is_context_needed': False}]

Forty-two patients with stage III to IV resectable HNSCC and nasopharyngeal tumors received induction chemotherapy with two courses of cisplatin ( 20 mg/m2/d continuous infusion [ CI ] ) , fluorouracil ( 800 mg/m2/d CI ) , and leucovorin ( 500 mg/m2/d CI ; PFL ) for 4 days followed by concurrent therapy with cisplatin ( 100 mg/m2/d on days 1 and 22 ) and approximately 70 Gy of external-beam radiotherapy .

[{'class': 'POS', 'spans': ['cisplatin', 'fluorouracil', 'leucovorin'], 'is_context_needed': True}]

The saliva is shown to inhibit human platelet aggregation induced by thrombin , collagen , adenosine diphosphate ( ADP ) , epinephrine , platelet activating factor ( 1-O-alkyl-2-acetyl-sn-3-glycerophophoryl choline [ PAF ] ) , and arachidonic acid .

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This clinical trial compared the efficacy of paclitaxel and vinorelbine in breast cancer neoadjuvant chemotherapy .

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Will a combination of l-leucine with low-dose metformin and sildenafil produce a novel synergistic interaction that reduces body weight ?

[{'class': 'POS', 'spans': ['l-leucine', 'metformin', 'sildenafil'], 'is_context_needed': True}]

Combinatory activity of linezolid and levofloxacin with antituberculosis drugs in Mycobacterium tuberculosis .

[{'class': 'POS', 'spans': ['linezolid', 'levofloxacin'], 'is_context_needed': True}]

Canadian clinical guidelines recommend the use of the combination of tamsulosin and dutasteride for men with moderate/severe symptoms associated with BPH and enlarged prostate volume .

[{'class': 'POS', 'spans': ['tamsulosin', 'dutasteride'], 'is_context_needed': False}]

The present study was designed to test the effects of chronic combined treatment with low doses of an angiotensin converting enzyme inhibitor ( perindopril ) and of the diuretic indapamide in spontaneously hypertensive rats ( SHR ) .

[{'class': 'POS', 'spans': ['perindopril', 'indapamide'], 'is_context_needed': True}]

A phase 3 trial of azacitidine versus a semi-intensive fludarabine and cytarabine schedule in older patients with untreated acute myeloid leukemia .

[{'class': 'NEG', 'spans': ['fludarabine', 'cytarabine'], 'is_context_needed': True}]

Five other treatments closely followed ( dabrafenib [ HR PFS : 0.30 ] , nivolumab plus ipilimumab [ HR PFS : 0.34 ] , vemurafenib [ HR PFS : 0.38 ] , nivolumab [ HR PFS : 0.42 ] and pembrolizumab [ HR PFS : 0.46 ] ) .

[{'class': 'POS', 'spans': ['nivolumab', 'ipilimumab'], 'is_context_needed': True}]

IGROV-1/APL resistant cell line shows the typical MDR phenotype : ( 1 ) increased expression of membrane-associated P-glycoprotein , ( 2 ) cross-resistance to drugs like etoposide , doxorubicin , vinblastine , vincristine , taxol , colchicin and the novel anticancer drug Yondelis ( ET-743 ) .

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Patients with newly diagnosed , locally advanced stage III or IV SCCHN received 4 weekly doses of carboplatin ( area under the curve , 1.5 ) and paclitaxel ( 45 mg/m(2 ) ) concurrently with concomitant boost radiation consisting of 72 grays in 42 fractions over 6 weeks ( every day for 18 days , twice a day for 12 days ) ( grading determined according to the TNM staging system ) .

[{'class': 'POS', 'spans': ['carboplatin', 'paclitaxel'], 'is_context_needed': True}]

Phase 1b trial of docetaxel , prednisone , and pazopanib in men with metastatic castration-resistant prostate cancer .

[{'class': 'POS', 'spans': ['docetaxel', 'prednisone', 'pazopanib'], 'is_context_needed': True}]