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The results indicate that bombesin and acetylcholine are the main intramural neural regulators of gastrin and somatostatin secretion . | [] |
Synergistic effects were seen between zeaxanthin and resveratrol or meclofenamic acid . | [{'class': 'POS', 'spans': ['resveratrol', 'zeaxanthin'], 'is_context_needed': False}, {'class': 'POS', 'spans': [1, 2], 'is_context_needed': False}] |
Among the non-faecalis organisms , penicillin resistance was significantly more frequent among isolates from patients given penicillin than from patients not given this antibiotic , and clindamycin resistance was significantly more frequent among isolates from patients given lincomycin and clindamycin than from patients not given these antibiotics . | [] |
Fifthteen patients were included : 12 underwent erlotinib treatment and 3 a crizotinib treatment . | [] |
The combination of trastuzumab with paclitaxel ( Taxol ) is well approved . | [{'class': 'POS', 'spans': ['trastuzumab', 'paclitaxel'], 'is_context_needed': False}, {'class': 'POS', 'spans': [0, 2], 'is_context_needed': False}] |
Intensive regimen of combined immunosuppressive therapy ( high-dose corticosteroids , oral cyclosporin and intravenous cyclophosphamide ( IVCY , 900 - 1000 mg/m(2 ) in every other week ) ) improved the survival rate of anti-MDA5-positive patients . | [{'class': 'POS', 'spans': ['cyclosporin', 'cyclophosphamide', 'corticosteroids'], 'is_context_needed': False}] |
Drug sensitivity was associated with hsa-let-7a-5p for Bortezomib , hsa-miR-135a-3p for JNJ-707 and hsa-miR-185 - 3p for Panobinostat . | [] |
No previous case of pulmonary interstitial changes that appeared in association with regorafenib administration for HCC and that were exacerbated by subsequent treatment with lenvatinib has been reported . | [{'class': 'NEG', 'spans': ['regorafenib', 'lenvatinib'], 'is_context_needed': False}] |
Treatment of articular manifestations of Lyme borreliosis is based on doxycycline , ceftriaxone , or amoxicillin for 28 days . | [] |
Serious adverse events were reported by 24 ( 34 % ) of 71 patients receiving olaparib and abiraterone ( seven of which were related to treatment ) and 13 ( 18 % ) of 71 patients receiving placebo and abiraterone ( one of which was related to treatment ) . | [{'class': 'POS', 'spans': ['olaparib', 'abiraterone'], 'is_context_needed': True}] |
In autoperfused hindquarters , the pressor-response curve to noradrenaline was dose-dependently shifted to the left by propranolol and to the right by labetalol or prazosin . | [] |
Expert opinion : Rivastigmine , a drug that increases cholinergic tone by inhibiting the enzyme cholinesterase , is effective for dementia , whereas the use of Donepezil is still in the realm of investigation . | [] |
Chemotherapy with methotrexate , cyclophosphamide , vincristine , doxorubicin , etoposide , and dexamethasone was effective , and the patient has been free from the disease for 1 year since completion of consolidation treatment with autologous peripheral blood stem cell transplantation . | [{'class': 'POS', 'spans': ['methotrexate', 'cyclophosphamide', 'vincristine', 'doxorubicin', 'etoposide', 'dexamethasone'], 'is_context_needed': False}] |
We have examined whether the DNA-damaging agents etoposide ( VP-16 ) and doxorubicin can affect IL-8 , VEGF , and HIF-1 expressions in human melanoma cancer cells . | [] |
The effect of combined therapy with tamsulosin hydrochloride and meloxicam in patients with benign prostatic hyperplasia symptoms and impact on nocturia and sleep quality . | [{'class': 'POS', 'spans': ['tamsulosin', 'meloxicam'], 'is_context_needed': True}] |
We investigated two human ( RD2 and TE 671 ) cell lines by cultivating them with doxorubicin , cisplatinum , and etoposide . | [{'class': 'COMB', 'spans': ['doxorubicin', 'etoposide', 'cisplatinum'], 'is_context_needed': True}] |
Retrospective study on antihyperlipidemic efficacy and safety of simvastatin , ezetimibe and their combination in Korean adults . | [{'class': 'POS', 'spans': ['simvastatin', 'ezetimibe'], 'is_context_needed': True}] |
The primary melanoma was surgically resected , and combination hepatic arterial infusion ( HAI ) therapy using dacarbazine , nimustine , vincristine ( DAV ) , and cisplatin was applied to the metastatic focus . | [{'class': 'POS', 'spans': ['dacarbazine', 'nimustine', 'vincristine', 'cisplatin'], 'is_context_needed': True}] |
These results were similar to those of previously reported salvage therapies for relapsed AML including intensive chemotherapy consisting of intermediate-dose Ara-C and sequential mitoxantrone with or without etoposide ( MC/MEC ) , which we previously adopted . | [{'class': 'COMB', 'spans': ['Ara-C', 'mitoxantrone'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 1, 2], 'is_context_needed': True}] |
Sensitivity of the test samples to the anti-cancer drugs cisplatin ( CDDP ) , doxorubicin ( DXR ) and etoposide ( VP-16 ) was examined using the MTT¿3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl [2H]-tetrazolium bromide ¿ assay . | [] |
In this phase I study , we combined cyclophosphamide , alvocidib and rituximab ( CAR ) in a schema designed to mitigate tumor lysis syndrome ( TLS ) seen previously with alvocidib . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'alvocidib', 'rituximab'], 'is_context_needed': True}] |
Newer-generation recombinant tissue-type plasminogen activators , such as desmoteplase and tenecteplase , will also help extend the time window . | [] |
Sixty-two analyzable patients with predominantly intermediate-grade non-Hodgkin lymphoma received cyclophosphamide ( 200 mg/m(2 ) per day ) , doxorubicin ( 12.5 mg/m(2 ) per day ) , and etoposide ( 60 mg/m(2 ) per day ) ( CDE ) by continuous intravenous infusion for 4 days ( 96 hours ) every 3 weeks for a maximum of 8 cycles . | [{'class': 'COMB', 'spans': ['cyclophosphamide', 'doxorubicin', 'etoposide'], 'is_context_needed': True}] |
Preinjection of blocking doses of unlabeled epibatidine , (-)-nicotine , lobeline and cytisine significantly inhibited [18F]FPH binding in thalamus and superior colliculus , but not in cerebellum , whereas drugs that interact with binding sites other than acetylcholine recognition sites of nAChR ( e.g. , mecamylamine , scopolamine , N-methylspiperone and ketanserin ) had no effect on [18F]FPH accumulation in any of the brain regions examined . | [] |
The combination carboplatin 35 mg/m2 , etoposide 50 mg/m2 , and ifosfamide 1,200 mg/m2 was administered intravenously daily for 3 consecutive days . | [{'class': 'POS', 'spans': ['carboplatin', 'etoposide', 'ifosfamide'], 'is_context_needed': True}] |
Aspirin regulation of c-myc and cyclinD1 proteins to overcome tamoxifen resistance in estrogen receptor-positive breast cancer cells . | [] |
Eighty-three patients were in the control group who have performed a surgical intervention with pre-operative 120-hour antibiotic prophylaxis by Claforan ( cefotaxime ) combining with Metrogel ( metronidazole ) . | [{'class': 'POS', 'spans': ['cefotaxime', 'metronidazole'], 'is_context_needed': True}] |
The regimen was CD DP 40 mg/m2 day 1 and 6 , 5-FU 600 mg/m2 day 2 and 4 , leucovorin 20 mg/m2 day 2 and 4 , etoposide 60 mg/m2 day 3 and 5 , and doxorubicin 20 mg/m2 day 7 , with repetition every 28 days . | [{'class': 'POS', 'spans': ['CD DP', 'leucovorin', 'etoposide', 'doxorubicin', '5-FU'], 'is_context_needed': True}] |
A German Hodgkin 's lymphoma ( HL ) study group designed the BEACOPP ( bleomycin , etoposide , doxorubicin , cyclophosphamide , vincristine , procarbazine , prednisolone ) regimen . | [{'class': 'POS', 'spans': ['bleomycin', 'etoposide', 'doxorubicin', 'cyclophosphamide', 'vincristine', 'procarbazine', 'prednisolone'], 'is_context_needed': True}] |
High-risk node-negative or low-risk node-positive breast cancer patients received AC given : ( arm I ) concurrently ( AC ) doxorubicin 54 mg/m2 and cyclophosphamide 1.2 g/m2 intravenously ( IV ) every 3 weeks for six cycles ; or ( arm II ) in sequence ( A C ) doxorubicin 40.5 mg/m2 IV days 1 and 2 every 3 weeks for four cycles followed by cyclophosphamide 2.4 gm/m2 IV every 2 weeks for three cycles . | [{'class': 'COMB', 'spans': ['doxorubicin', 'cyclophosphamide'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3], 'is_context_needed': True}] |
The CAV/PE-W consisted of 4 alternating cycles of cyclophosphamide : 500 mg/m2 , doxorubicin : 30 mg/m2 , and vincristine : 1 mg/m2 ( day 1 ) and cisplatin : 50 mg/m2 ( day 8) and etoposide : 75 mg/m2 ( days 8 and 9 ) . | [{'class': 'POS', 'spans': ['cyclophosphamide', 'doxorubicin', 'vincristine', 'cisplatin', 'etoposide'], 'is_context_needed': True}] |
Cyclophosphamide , methotrexate , 5-fluorouracil , and folinic acid ( CMFF ) as first line chemotherapy for treatment of advanced breast cancer . | [{'class': 'COMB', 'spans': ['Cyclophosphamide', 'methotrexate', '5-fluorouracil', 'folinic acid'], 'is_context_needed': True}] |
High doses of rosuvastatin are superior to low doses of rosuvastatin plus fenofibrate or n-3 fatty acids in mixed dyslipidemia . | [{'class': 'NEG', 'spans': ['rosuvastatin', 'fenofibrate'], 'is_context_needed': False}] |
Patients were divided randomly into 3 groups ( Group A : 0.5 % bupivacaine 5 mL , n = 12 ; Group B : 0.5 % bupivacaine 4.5 mL + 20 mg of triamcinolone 0.5 mL , n = 10 ; and Group C : 0.5 % bupivacaine 4 mL + 40 mg of triamcinolone 1 mL , n = 10 ) . | [{'class': 'POS', 'spans': ['bupivacaine', 'triamcinolone'], 'is_context_needed': True}, {'class': 'POS', 'spans': [3, 4], 'is_context_needed': True}] |
Irinotecan and etoposide were combined using the ( d x 5)2 i.v . schedule for both drugs , in which irinotecan was given 2 h before or 2 h after the administration of etoposide . | [{'class': 'NEG', 'spans': ['Irinotecan', 'etoposide'], 'is_context_needed': True}, {'class': 'NEG', 'spans': [2, 3], 'is_context_needed': True}] |
Combination of sofosbuvir , pegylated-interferon and ribavirin for treatment of hepatitis C virus genotype 1 infection : a systematic review and meta-analysis . | [{'class': 'POS', 'spans': ['sofosbuvir', 'pegylated-interferon', 'ribavirin'], 'is_context_needed': True}] |
Immunosuppressive protocol : preoperative : Cyclosporin + Azathioprine . | [{'class': 'COMB', 'spans': ['Cyclosporin', 'Azathioprine'], 'is_context_needed': True}] |
Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma . | [] |
All patients received chemotherapy regimens that included doxorubicin ( 6 ) or etoposide ( 1 ) , and six were treated with infradiaphragmatic irradiation . | [] |
Of 1490 articles identified , we included 3 papers and 1 abstract with patients on aspirin and/or NSAIDs , 1 paper on warfarin , 2 abstracts on clopidogrel , and 2 papers on clopidogrel plus aspirin and/or NSAIDs . | [] |
Topoisomerase IIalpha mRNA expression levels did not reflect sensitivity to doxorubicin or etoposide . | [] |
We observed that efavirenz and etravirine induce metabolism of co-administered drugs by binding to a unique position in the active site of CYP3A4 . | [] |
First , we searched for the most synergistic combination of KPT-8602 with dexamethasone , vincristine , or doxorubicin | [{'class': 'POS', 'spans': ['KPT-8602', 'dexamethasone'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 2], 'is_context_needed': True}, {'class': 'COMB', 'spans': [0, 3], 'is_context_needed': True}] |
In Thailand , artesunate and artemether are the mainly used antimalarials for treatment of severe or multidrug resistant falciparum malaria . | [] |
Epidural analgesia during labor--0.5 % lidocaine with fentanyl vs. 0.08 % ropivacaine with fentanyl . | [{'class': 'COMB', 'spans': ['lidocaine', 'fentanyl'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3], 'is_context_needed': True}] |
Inhibition of Boyden Chamber migration of MNL 's in a MNL-lymphocyte mixture was achieved after 1/2 hr incubation by 10(-3 ) and 10(-4 ) mol/L. concentrations of chloroquine ( maximum inhibition 63 % + /- 2.8 ) , dexamethasone ( 58 % + /- 8.6 ) , 6-mercaptopurine ( 62 % + /- 4.2 ) , methotrexate ( 66 % + /- 6.4 ) , and vinblastine ( 100 % ) . | [] |
The proactive intense care strategy was applied , which includes : ( i ) an education and training course on the topic of SLE-PAH for ED physicians ; ( ii ) a SLE-PAH patient triage protocol with prompt specialist consultation and admission ; and ( iii ) intensive care with prompt initiation of combination PAH-targeted therapy , that is , at least two drugs from the three categories as represented by iloprost , bosentan and sildenafil . | [{'class': 'POS', 'spans': ['iloprost', 'bosentan', 'sildenafil'], 'is_context_needed': True}] |
Adding sulbactam to piperacillin resulted in increased susceptibility rates among piperacillin-resistant P. aeruginosa ( 53 - 57 % in either 2:1 or 4:1 ratios ) and A. baumannii ( 38 - 46 % in either 2:1 ratio or a fixed 8 mg/L concentration of sulbactam ) isolates . | [{'class': 'POS', 'spans': ['sulbactam', 'piperacillin'], 'is_context_needed': False}] |
Senescence can be efficiently induced in cultured cells by DNA-damaging drugs , including doxorubicin ( DOX ) , cisplatin and etoposide . | [] |
Preoperative treatment was 5 fractions radiation therapy ( 25 Gy to involved mesorectum , 20 Gy to elective nodes ) , followed by 4 cycles of FOLFOX [ 5-fluorouracil , oxaliplatin , leucovorin ] . | [{'class': 'POS', 'spans': ['oxaliplatin', 'leucovorin', '5-fluorouracil'], 'is_context_needed': True}] |
The cost-effectiveness of dapagliflozin versus sulfonylurea as an add-on to metformin in the treatment of Type 2 diabetes mellitus . | [{'class': 'POS', 'spans': ['dapagliflozin', 'metformin'], 'is_context_needed': True}] |
The mean reduction of night time points was statistically lower than that of day time points for latanoprost ( P = 0.031 ) , timolol ( P = 0.032 ) , and brimonidine ( P = 0.050 ) , but not for dorzolamide ( P = 0.60 ) , bimatoprost ( P = 0.057 ) , travoprost ( P = 0.064 ) . | [] |
Moreover , the beneficial effects of dronedarone , amiodarone analogues , against Trypanosoma cruzi and Leishmania mexicana have recently been demonstrated and such treatment regimens resulted in lower side effects . | [] |
This study aimed to investigate the efficacy and safety of iguratimod ( T-614 ) in combination with methotrexate ( MTX ) for active rheumatoid arthritis ( RA ) patients . | [{'class': 'POS', 'spans': ['iguratimod', 'methotrexate'], 'is_context_needed': True}] |
Cyclophosphamide , doxorubicin , vincristine , and prednisone ( CHOP ) or CHOP-like regimens have been the backbone while more intensive regimens such as cyclophosphamide , vincristine , doxorubicin , high-dose methotrexate/ifosfamide , etoposide , high-dose cytarabine ( CODOX-M/IVAC ) , or dose-adjusted etoposide , prednisone , vincristine , cyclophosphamide , and doxorubicin ( DA-EPOCH ) are possible options . | [{'class': 'COMB', 'spans': ['Cyclophosphamide', 'doxorubicin', 'vincristine', 'prednisone'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [4, 5, 6, 7, 8, 14], 'is_context_needed': True}, {'class': 'COMB', 'spans': [9, 10, 11, 12, 13], 'is_context_needed': True}] |
Irinotecan tended to result in more gastrointestinal tract reactions than oxaliplatin did , but the myelosuppression and neurotoxicity were more frequent in oxaliplatin regimen than irinotecan regimen . | [] |
[ Intraoperative anaphylactic shock induced by methylergometrine and oxytocin ] . | [{'class': 'COMB', 'spans': ['methylergometrine', 'oxytocin'], 'is_context_needed': True}] |
Overexpression of MK in wild type neuroblastoma cells leads to acquired drug resistance to doxorubicin and to the related drug etoposide . | [] |
The only approved second-line therapies for patients without targetable oncogenic drivers are docetaxel , gemcitabine , pemetrexed , and erlotinib and for patients with target-specific oncogenes afatinib , osimertinib , crizotinib , alectinib , and ceritinib . | [] |
an increase in serious adverse events with both regular formoterol and regular salmeterol in chronic asthma has been demonstrated in comparison with placebo in previous Cochrane reviews . | [] |
[ An elderly patient with myelodysplastic syndrome successfully treated with combination of granulocyte-colony stimulating factor and continuous-drip infusion of low-dose cytarabine and etoposide ] . | [{'class': 'POS', 'spans': ['cytarabine', 'etoposide'], 'is_context_needed': False}] |
Among the GNB , a higher prevalence of resistance was observed against cefoxitin ( 93.1 % ) followed by ampicillin ( 79.4 % ) , chloramphenicol ( 72.6 % ) , ceftizoxime ( 65.7 % ) , aztreonam ( 64.9 % ) , cefotaxime ( 53.6 % ) , imipenem ( 38.3 % ) , ceftazidime ( 33.5 % ) , gentamicin ( 32.6 % ) , tetracycline ( 22.2 % ) , and ciprofloxacin ( 19.8 % ) . | [{'class': 'COMB', 'spans': ['cefoxitin', 'ampicillin', 'chloramphenicol', 'ceftizoxime', 'aztreonam', 'cefotaxime', 'imipenem', 'ceftazidime', 'gentamicin', 'tetracycline', 'ciprofloxacin'], 'is_context_needed': True}] |
The results suggested that irinotecan , 5-FU and leucovorin combination chemotherapy in a biweekly schedule is a practical and tolerable treatment option in patients with advanced colorectal cancer . | [{'class': 'POS', 'spans': ['irinotecan', '5-FU', 'leucovorin'], 'is_context_needed': False}] |
Fifty-three consecutive patients with active duodenal ulcer ( DU ) were randomly included in a double-blind , double-dummy study to test the healing and relapsing rate of two treatment regimens : famotidine 40 mg nocte for 4 - 8 weeks , followed by 20 mg for 12 months after healing of the ulcer and colloidal bismuth ( CBS ) ( 240 mg bid ) for 4 - 8 weeks , followed by placebo maintenance treatment . | [] |
Cytotoxic monotherapy was the most frequently prescribed regimen ( N = 60 , 46 % ) in 2L , followed by combination therapies ( N = 45 , 35 % ) , pembrolizumab monotherapy ( N = 19 , 15 % ) , and bevacizumab monotherapy ( N = 6 , 5 % ) . | [] |
Terlipressin administration in rats pre-treated with octreotide further decreased portal pressure , portal tributary blood flow and increased hepatocollateral vascular resistance ; terlipressin increased arterial pressure and further decreased cardiac index . | [{'class': 'COMB', 'spans': ['Terlipressin', 'octreotide'], 'is_context_needed': True}] |
Results confirmed the antidepressant action of alprazolam and imipramine . | [] |
Cell viability of two human hepatoma cell lines ( Huh7 and Hep-G2 ) was quantitatively investigated under the treatment of two drugs ( doxorubicin and etoposide ) . | [] |
MIF , TRH , and its analog PR-546 , the paraopioid RP , leuenkephalin , dalargin , the ACTH analogue Semax , tafcin , thymosine , interleukin-1 , vasopressin , oxytocin , bradykinin , defencin , and some proline-containing oligopeptides , such as Pro-Gly , Gly-Pro , Trp-Pro , Pro-Gly-Pro , Gly-Pro-Gly-Gly were studied . | [] |
In both cohorts , more than 40 % of patients discontinued their index drugs ( 46.4 % pazopanib and 44.1 % sunitinib , P = 0.732 ) . | [] |
The patients were heavily pretreated with anthracycline ( 100 % ) , taxane ( paclitaxel or docetaxel ) ( 100 % ) , capecitabine ( 100 % ) , vinorelbine ( 71 % ) , and mitomycin ( 69 % ) . | [] |
Therapy includes debridement of necrotic bone and loculated purulence combined with amphotericin B and possibly 5-fluorocytosine or rifampin . | [] |
Docetaxel and cisplatin were given at 75 mg/m(2 ) , while capecitabine was initially given at 500 mg/m(2 ) twice a day and subsequently escalated . | [{'class': 'NEG', 'spans': ['Docetaxel', 'cisplatin', 'capecitabine'], 'is_context_needed': True}] |
A colorectal cancer cell line ( LOVO cell ) treated by curcumin combined with irinotecan in different ways respectively was used as our comparative model . | [{'class': 'POS', 'spans': ['curcumin', 'irinotecan'], 'is_context_needed': True}] |
The use of ceftriaxone plus doxycycline as an initial empiric therapy for patients hospitalized with CAP appears safe and effective , and its potential superiority should be evaluated prospectively . | [{'class': 'POS', 'spans': ['doxycycline', 'plus'], 'is_context_needed': False}] |
Metformin ( 50 mg/kg/day ) , genistein ( 20 mg/kg/day ) and combination of genistein and metformin was administered in alloxan-induced diabetic rats . | [{'class': 'POS', 'spans': ['genistein', 'metformin'], 'is_context_needed': True}] |
CYP3A5 ( intron 3 ) and MDR1 ( exons 12 , 21 , 26 ) genotypes were correlated to the adjusted trough concentrations and dose requirements for both sirolimus and tacrolimus . | [] |
Here we report the results of a multicenter retrospective trial evaluating ASCT in patients with transformed lymphoma using the Z-BEAM conditioning regimen , which combines yttrium-90-labeled ibritumomab tiuxetan ( Zevalin ) with high-dose BEAM ( carmustine , etoposide , cytarabine , melphalan ) chemotherapy . | [{'class': 'POS', 'spans': ['ibritumomab tiuxetan', 'carmustine', 'etoposide', 'cytarabine', 'melphalan'], 'is_context_needed': True}] |
Palbociclib is a selective cyclin-dependent kinase ( CDK ) 4/6 inhibitor used in combination with aromatase inhibitors or fulvestrant for patients with hormone receptor-positive ( HR+ ) human epidermal growth factor receptor 2 (HER2)-negative advanced/metastatic breast cancer ( ABC/MBC ) . | [{'class': 'POS', 'spans': ['Palbociclib', 'fulvestrant'], 'is_context_needed': True}] |
Triplet schedule of weekly 5-fluorouracil and alternating irinotecan or oxaliplatin in advanced colorectal cancer : a dose-finding and phase II study . | [{'class': 'POS', 'spans': ['5-fluorouracil', 'irinotecan', 'oxaliplatin'], 'is_context_needed': True}] |
After larvae were infected with S. aureus , larval survival was enhanced by administering the antistaphylococcal antibiotics daptomycin or vancomycin . | [] |
In terms of progression-free survival ( PFS ) , axitinib was superior compared with placebo ( HR = 0.25 , 95 % CrI : 0.17 - 0.38 ) , sorafenib ( HR = 0.46 , 95 % CrI : 0.32 - 0.68 ) and pazopanib ( HR = 0.47 , 95 % CrI : 0.26 - 0.85 ) . | [] |
Concomitant and sequential treatment with paclitaxel and gemcitabine had no significant difference in terms of PFS . | [{'class': 'COMB', 'spans': ['paclitaxel', 'gemcitabine'], 'is_context_needed': True}] |
Efficacy of Margetuximab vs Trastuzumab in Patients With Pretreated ERBB2-Positive Advanced Breast Cancer : A Phase 3 Randomized Clinical Trial . | [] |
She was treated with a combination of four cycles of cyclophosphamide , hydroxydaunorubicin , vincristine , and prednisolone ( CHOP ) regimen followed by local radiotherapy ( 36 Gray/20 fractions/4 weeks ) by three-dimensional conformal technique . | [] |
We compared such treatment with docetaxel plus prednisone in men with this disease . | [{'class': 'POS', 'spans': ['docetaxel', 'prednisone'], 'is_context_needed': True}] |
Magnocellular neurons of the hypothalamo-neurophypophysial system synthesize either vasopressin or oxytocin ; water deprivation and chronic saline ingestion are potent stimuli for the expression of both of the genes encoding these neuropeptides . | [] |
Combination chemotherapy has been established to have superior response rates and progression-free survival and -- in some instances , for fluorouracil and irinotecan combinations -- improved overall survival compared to fluorouracil alone . | [{'class': 'POS', 'spans': ['fluorouracil', 'irinotecan'], 'is_context_needed': False}] |
Phase IV study of bevacizumab in combination with infusional fluorouracil , leucovorin and irinotecan ( FOLFIRI ) in first-line metastatic colorectal cancer . | [{'class': 'POS', 'spans': ['bevacizumab', 'fluorouracil', 'leucovorin', 'irinotecan'], 'is_context_needed': True}] |
In addition , multidrug resistance of Hep-2-CSCs to vincristine , etoposide and doxorubicin was greatly improved after the cells were transfected with microRNA-125a mimics . | [] |
Nine patients received a combination of cisplatin and etoposide ( EP ) , 5 had cyclophosphamide , doxorubicin and vincristine , 1 had cyclophosphamide , etoposide and vincristine and 1 had monotherapy with oral etoposide . | [{'class': 'COMB', 'spans': ['cisplatin', 'etoposide'], 'is_context_needed': True}, {'class': 'COMB', 'spans': [2, 3, 4], 'is_context_needed': True}, {'class': 'COMB', 'spans': [5, 6, 7], 'is_context_needed': True}] |
Tetracycline ( TC ) and chlortetracycline ( CTC ) are used extensively for growth promotion and therapeutic purposes in livestock production . | [] |
Comparing the combination of nalidixic acid and metronidazole with metronidazole alone , 17.5 % more children treated with the combination recovered by day 3 of treatment ( p = 0.08 ) and the mean stool frequency ascertained on day 7 for the previous 24 h was 26.8 % less in them ( p = 0.05 ) . | [{'class': 'POS', 'spans': ['nalidixic acid', 'metronidazole'], 'is_context_needed': False}] |
The management is primarily based on pharmacological agents and in clinical practice propranolol and primidone are considered the first-line therapy . | [{'class': 'POS', 'spans': ['propranolol', 'primidone'], 'is_context_needed': True}] |
In vitro sensitivity of HT29 human colon cancer cells to doxorubicin ( DXR ) , vincristine ( VCR ) , etoposide ( VP16 ) , cisplatin ( CDDP ) , melphalan ( L-PAM ) and 5-fluorouracil ( 5FU ) was markedly reduced when cell-culture density increased . | [] |
ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy . | [{'class': 'COMB', 'spans': ['oxaliplatin', 'fluorouracil'], 'is_context_needed': True}] |
7 patients ( 53 % ) receiving pamidronate and thalidomide therapy demonstrated good response involving at least 25 % reduction of monoclonal protein levels in comparison with baseline . | [{'class': 'POS', 'spans': ['pamidronate', 'thalidomide'], 'is_context_needed': False}] |
Growth inhibition was measured by 3H-thymidine incorporation assays for doxorubicin hydrochloride ( ADM ) , mitomycin C ( MMC ) , cisplatin ( CDDP ) , and etoposide ( VP-16 ) , and by Alamar Blue assay for ( AB assay ) 5-fluorouracil ( 5-FU ) . | [] |
A similar relapse rate was also obtained with a 6-month completely oral regimen including TMC207 , moxifloxacin and pyrazinamide but excluding both amikacin and ethionamide . | [{'class': 'POS', 'spans': ['TMC207', 'moxifloxacin', 'pyrazinamide'], 'is_context_needed': True}, {'class': 'POS', 'spans': [1, 2, 3, 4], 'is_context_needed': True}] |
Phase I Clinical Trial of Combination Propranolol and Pembrolizumab in Locally Advanced and Metastatic Melanoma : Safety , Tolerability , and Preliminary Evidence of Antitumor Activity . | [{'class': 'POS', 'spans': ['Propranolol', 'Pembrolizumab'], 'is_context_needed': True}] |
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