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DS.d936
18754103
[ { "id": "DS.d936.s0", "type": "", "text": [ "To investigate any similarities in the inhibition of CYP2E1 by quinacrine and disulfiram, molecular modeling techniques were adopted and revealed that quinacrine molecule anchors inside the same binding pocket of the protein where disulfiram is also attached." ], "offsets": [ [ 0, 259 ] ] } ]
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[]
[]
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DS.d937
18754105
[ { "id": "DS.d937.s0", "type": "", "text": [ "administered during 7 days at 20 mg/kg per day (subacute treatment), resveratrol abrogated LPS-induced erythrocytes lipoperoxidation and catalase (CAT) activity depression to control levels." ], "offsets": [ [ 0, 190 ] ] } ]
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"db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PWF7" } ] } ]
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[ { "id": "DS.d937.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d937.s0.e0", "arg2_id": "DS.d937.s0.e2", "normalized": [] }, { "id": "DS.d937.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d937.s0.e0", "arg2_id": "DS.d937.s0.e1", "normalized": [] } ]
DS.d938
18754702
[ { "id": "DS.d938.s0", "type": "", "text": [ "H2S can be produced from cysteine by enzymes such as cystathionine beta-synthase." ], "offsets": [ [ 0, 81 ] ] } ]
[ { "id": "DS.d938.s0.e0", "type": "compound", "text": [ "cysteine" ], "offsets": [ [ 25, 33 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "594" }, { "db_name": "PubChem", "db_id": "5862" }, { "db_name": "PubChem", "db_id": "5360637" } ] }, { "id": "DS.d938.s0.e1", "type": "protein", "text": [ "cystathionine beta-synthase" ], "offsets": [ [ 53, 80 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P32232" }, { "db_name": "UniProt", "db_id": "P32582" }, { "db_name": "UniProt", "db_id": "P35520" }, { "db_name": "UniProt", "db_id": "P46794" }, { "db_name": "UniProt", "db_id": "Q58H57" }, { "db_name": "UniProt", "db_id": "Q91WT9" }, { "db_name": "UniProt", "db_id": "Q9N0V7" }, { "db_name": "UniProt", "db_id": "Q9YBL2" } ] } ]
[]
[]
[ { "id": "DS.d938.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d938.s0.e0", "arg2_id": "DS.d938.s0.e1", "normalized": [] } ]
DS.d939
18754757
[ { "id": "DS.d939.s0", "type": "", "text": [ "The influence of carbon sources on rhGH (recombinant human growth hormone) production by two Pichia pastoris strains having different methanol utilization phenotypes (P. pastoris-hGH-Mut (+) and P. pastoris-hGH-Mut (s)) was investigated using batch bioreactors." ], "offsets": [ [ 0, 261 ] ] } ]
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[]
[]
[]
DS.d940
18754816
[ { "id": "DS.d940.s0", "type": "", "text": [ "The present study was undertaken to test the hypothesis that PPARalpha activator fenofibrate plays a key role in left ventricular hypertrophic remodelling via the formation of c-fos/c-jun heterodimers in spontaneous hypertensive rats (SHRs)." ], "offsets": [ [ 0, 241 ] ] } ]
[ { "id": "DS.d940.s0.e0", "type": "compound", "text": [ "fenofibrate" ], "offsets": [ [ 81, 92 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3339" } ] }, { "id": "DS.d940.s0.e1", "type": "protein", "text": [ "fos" ], "offsets": [ [ 178, 181 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01101" }, { "db_name": "UniProt", "db_id": "P12841" }, { "db_name": "UniProt", "db_id": "Q56415" } ] }, { "id": "DS.d940.s0.e2", "type": "protein", "text": [ "jun" ], "offsets": [ [ 184, 187 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05627" }, { "db_name": "UniProt", "db_id": "P17325" }, { "db_name": "UniProt", "db_id": "P18289" } ] } ]
[]
[]
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DS.d941
18755047
[ { "id": "DS.d941.s0", "type": "", "text": [ "Effects of eicosapentaenoic acid ethyl ester on visfatin and apelin in lean and overweight (cafeteria diet-fed) rats." ], "offsets": [ [ 0, 117 ] ] } ]
[ { "id": "DS.d941.s0.e0", "type": "compound", "text": [ "eicosapentaenoic acid" ], "offsets": [ [ 11, 32 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "446284" } ] }, { "id": "DS.d941.s0.e1", "type": "compound", "text": [ "ethyl ester" ], "offsets": [ [ 33, 44 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "8857" } ] }, { "id": "DS.d941.s0.e2", "type": "protein", "text": [ "visfatin" ], "offsets": [ [ 48, 56 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P43490" }, { "db_name": "UniProt", "db_id": "Q52I78" }, { "db_name": "UniProt", "db_id": "Q80Z29" }, { "db_name": "UniProt", "db_id": "Q99KQ4" } ] }, { "id": "DS.d941.s0.e3", "type": "compound", "text": [ "apelin" ], "offsets": [ [ 61, 67 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "56841713" } ] } ]
[]
[]
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DS.d942
18755051
[ { "id": "DS.d942.s0", "type": "", "text": [ "In the presence of AA (Fe:AA molar ratio of 1:20), significantly more Fe was absorbed from FeSO4 (about 303 %), HSF (about 454 %) and P-HSF (about 371 %) when compared with ferrous sulfate or ferritin without AA." ], "offsets": [ [ 0, 212 ] ] } ]
[ { "id": "DS.d942.s0.e0", "type": "protein", "text": [ "HSF" ], "offsets": [ [ 112, 115 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10961" }, { "db_name": "UniProt", "db_id": "P12850" }, { "db_name": "UniProt", "db_id": "P19875" }, { "db_name": "UniProt", "db_id": "P22121" }, { "db_name": "UniProt", "db_id": "P22813" }, { "db_name": "UniProt", "db_id": "P41154" }, { "db_name": "UniProt", "db_id": "Q02953" } ] }, { "id": "DS.d942.s0.e1", "type": "protein", "text": [ "HSF" ], "offsets": [ [ 136, 139 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10961" }, { "db_name": "UniProt", "db_id": "P12850" }, { "db_name": "UniProt", "db_id": "P19875" }, { "db_name": "UniProt", "db_id": "P22121" }, { "db_name": "UniProt", "db_id": "P22813" }, { "db_name": "UniProt", "db_id": "P41154" }, { "db_name": "UniProt", "db_id": "Q02953" } ] }, { "id": "DS.d942.s0.e2", "type": "compound", "text": [ "sulfate" ], "offsets": [ [ 181, 188 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1117" } ] }, { "id": "DS.d942.s0.e3", "type": "protein", "text": [ "ferritin" ], "offsets": [ [ 192, 200 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q26061" } ] } ]
[]
[]
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DS.d943
18755266
[ { "id": "DS.d943.s0", "type": "", "text": [ "Insulin-like growth factor-I (IGF-I) is neuroprotective against ethanol-related toxicity and promotes white matter production following a number of insults." ], "offsets": [ [ 0, 156 ] ] }, { "id": "DS.d943.s1", "type": "", "text": [ "These data indicate that IGF-I may be a potential treatment for some of ethanol's damaging effects, a finding that has important implications for children of women who drink alcohol during pregnancy." ], "offsets": [ [ 157, 356 ] ] } ]
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[]
[]
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DS.d944
18755506
[ { "id": "DS.d944.s0", "type": "", "text": [ "This study is aimed to investigate the effects of triethyleneglycol dimethacrylate (TEGDMA) and 2-hydroxyethyl methacrylate (HEMA) on expression of cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in cultured murine macrophage cell line RAW 264.7." ], "offsets": [ [ 0, 266 ] ] } ]
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[]
[]
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DS.d945
18755582
[ { "id": "DS.d945.s0", "type": "", "text": [ "SWCNT coatings were thus functionalized with poly(adamantane-pyrrole) and applied to the anchoring of glucose oxidase (GOX), modified with beta-cyclodextrin." ], "offsets": [ [ 0, 157 ] ] }, { "id": "DS.d945.s1", "type": "", "text": [ "This allows the immobilization of adamantane-tagged GOX." ], "offsets": [ [ 158, 214 ] ] } ]
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[]
[]
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DS.d946
18755616
[ { "id": "DS.d946.s0", "type": "", "text": [ "Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study." ], "offsets": [ [ 0, 116 ] ] }, { "id": "DS.d946.s1", "type": "", "text": [ "The purpose of this study was to investigate bone morphogenetic protein (BMP) 2 expression after implantation of a statin and recombinant human BMP-2 (rhBMP-2) and to compare the bone regeneration capability of these substances in the rabbit nasal bone using immunohistologic methods." ], "offsets": [ [ 117, 401 ] ] } ]
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[]
[]
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DS.d947
18755796
[ { "id": "DS.d947.s0", "type": "", "text": [ "cAMP, a second messenger in LH signaling, was identified as a factor in hCG-dependent regulation of Cdk5/p35." ], "offsets": [ [ 0, 109 ] ] } ]
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[]
[]
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DS.d948
18755820
[ { "id": "DS.d948.s0", "type": "", "text": [ "Intracellular production of TNFalpha and IL-2 after stimulation with phorbol myristate/ionomycin was flowcytometrically measured in CD4 (+) T cells from peripheral blood (PB) and cerebrospinal fluid (CSF) of 29 patients with multiple sclerosis (MS), and 16 with other inflammatory and 41 with other non-inflammatory neurological diseases." ], "offsets": [ [ 0, 338 ] ] } ]
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[]
[]
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DS.d949
18756496
[ { "id": "DS.d949.s0", "type": "", "text": [ "Although we reported that 8-Cl-cAMP induces growth inhibition via p38 mitogen-activated protein kinase (MAPK) and a metabolite of 8-Cl-cAMP, 8-Cl-adenosine mediates this process, the action mechanism of 8-Cl-cAMP is still uncertain." ], "offsets": [ [ 0, 232 ] ] } ]
[ { "id": "DS.d949.s0.e0", "type": "protein", "text": [ "MAPK" ], "offsets": [ [ 104, 108 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42781" }, { "db_name": "UniProt", "db_id": "P27638" }, { "db_name": "UniProt", "db_id": "Q00859" } ] }, { "id": "DS.d949.s0.e1", "type": "compound", "text": [ "adenosine" ], "offsets": [ [ 146, 155 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "60961" } ] } ]
[]
[]
[ { "id": "DS.d949.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d949.s0.e1", "arg2_id": "DS.d949.s0.e0", "normalized": [] } ]
DS.d950
18756527
[ { "id": "DS.d950.s0", "type": "", "text": [ "Certain non-steroidal anti-inflammatory drugs, e.g., the cyclooxygenase 2-specific nonsteroidal anti-inflammatory drugs, celecoxib, raise Abeta(42) levels." ], "offsets": [ [ 0, 155 ] ] } ]
[ { "id": "DS.d950.s0.e0", "type": "protein", "text": [ "cyclooxygenase 2" ], "offsets": [ [ 57, 73 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] }, { "id": "DS.d950.s0.e1", "type": "compound", "text": [ "celecoxib" ], "offsets": [ [ 121, 130 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2662" } ] } ]
[]
[]
[ { "id": "DS.d950.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d950.s0.e1", "arg2_id": "DS.d950.s0.e0", "normalized": [] } ]
DS.d951
18756589
[ { "id": "DS.d951.s0", "type": "", "text": [ "This was significantly in accordance with intracellular oxidative stress levels measured by glutathione depletion, malondialdehyde production, superoxide dismutase inhibition as well as reactive oxygen species generation." ], "offsets": [ [ 0, 221 ] ] } ]
[ { "id": "DS.d951.s0.e0", "type": "compound", "text": [ "glutathione" ], "offsets": [ [ 92, 103 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d951.s0.e1", "type": "compound", "text": [ "malondialdehyde" ], "offsets": [ [ 115, 130 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10964" } ] }, { "id": "DS.d951.s0.e2", "type": "protein", "text": [ "superoxide dismutase" ], "offsets": [ [ 143, 163 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50258" } ] }, { "id": "DS.d951.s0.e3", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 195, 201 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] } ]
[]
[]
[]
DS.d952
18757054
[ { "id": "DS.d952.s0", "type": "", "text": [ "Acrolein, IL-6 and CRP as markers of silent brain infarction." ], "offsets": [ [ 0, 61 ] ] }, { "id": "DS.d952.s1", "type": "", "text": [ "We found previously that increased levels of polyamine oxidase (PAO) (acetylpolyamine oxidase (AcPAO) plus spermine oxidase (SMO)), and acrolein (CH(2)CHCHO) are good markers of stroke." ], "offsets": [ [ 62, 247 ] ] }, { "id": "DS.d952.s2", "type": "", "text": [ "We then investigated whether silent brain infarction (SBI) can be detected by measuring acrolein, PAO, or other biomarkers." ], "offsets": [ [ 248, 371 ] ] }, { "id": "DS.d952.s3", "type": "", "text": [ "It was found that the levels of protein-conjugated acrolein (PC-Acro), interleukin-6 (IL-6) and C-reactive protein (CRP) were significantly higher in SBI than in normal subjects." ], "offsets": [ [ 372, 550 ] ] } ]
[ { "id": "DS.d952.s0.e0", "type": "compound", "text": [ "Acrolein" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7847" } ] }, { "id": "DS.d952.s0.e1", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 10, 14 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d952.s0.e2", "type": "protein", "text": [ "CRP" ], "offsets": [ [ 19, 22 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19062" }, { "db_name": "UniProt", "db_id": "P02741" }, { "db_name": "UniProt", "db_id": "P02742" }, { "db_name": "UniProt", "db_id": "P08462" }, { "db_name": "UniProt", "db_id": "P18151" }, { "db_name": "UniProt", "db_id": "P21291" }, { "db_name": "UniProt", "db_id": "P41964" }, { "db_name": "UniProt", "db_id": "P47875" }, { "db_name": "UniProt", "db_id": "P49254" }, { "db_name": "UniProt", "db_id": "P49262" }, { "db_name": "UniProt", "db_id": "P52753" }, { "db_name": "UniProt", "db_id": "P67966" }, { "db_name": "UniProt", "db_id": "P67967" }, { "db_name": "UniProt", "db_id": "P97315" }, { "db_name": "UniProt", "db_id": "Q07203" } ] }, { "id": "DS.d952.s1.e0", "type": "protein", "text": [ "polyamine oxidase" ], "offsets": [ [ 107, 124 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q6QHF9" }, { "db_name": "UniProt", "db_id": "Q865R1" }, { "db_name": "UniProt", "db_id": "Q8C0L6" } ] }, { "id": "DS.d952.s1.e1", "type": "protein", "text": [ "PAO" ], "offsets": [ [ 126, 129 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O64411" }, { "db_name": "UniProt", "db_id": "Q6QHF9" }, { "db_name": "UniProt", "db_id": "Q865R1" }, { "db_name": "UniProt", "db_id": "Q9FYC2" } ] }, { "id": "DS.d952.s1.e2", "type": "protein", "text": [ "spermine oxidase" ], "offsets": [ [ 169, 185 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q99K82" }, { "db_name": "UniProt", "db_id": "Q9NWM0" } ] }, { "id": "DS.d952.s1.e3", "type": "protein", "text": [ "SMO" ], "offsets": [ [ 187, 190 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42224" }, { "db_name": "UniProt", "db_id": "P56726" }, { "db_name": "UniProt", "db_id": "P97698" }, { "db_name": "UniProt", "db_id": "Q99835" }, { "db_name": "UniProt", "db_id": "Q9NWM0" } ] }, { "id": "DS.d952.s1.e4", "type": "compound", "text": [ "acrolein" ], "offsets": [ [ 198, 206 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7847" } ] }, { "id": "DS.d952.s2.e0", "type": "compound", "text": [ "acrolein" ], "offsets": [ [ 336, 344 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7847" } ] }, { "id": "DS.d952.s2.e1", "type": "protein", "text": [ "PAO" ], "offsets": [ [ 346, 349 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O64411" }, { "db_name": "UniProt", "db_id": "Q6QHF9" }, { "db_name": "UniProt", "db_id": "Q865R1" }, { "db_name": "UniProt", "db_id": "Q9FYC2" } ] }, { "id": "DS.d952.s3.e0", "type": "compound", "text": [ "acrolein" ], "offsets": [ [ 423, 431 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7847" } ] }, { "id": "DS.d952.s3.e1", "type": "protein", "text": [ "interleukin-6" ], "offsets": [ [ 443, 456 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P41693" } ] }, { "id": "DS.d952.s3.e2", "type": "protein", "text": [ "IL-6" ], "offsets": [ [ 458, 462 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35736" }, { "db_name": "UniProt", "db_id": "P05231" }, { "db_name": "UniProt", "db_id": "P08505" }, { "db_name": "UniProt", "db_id": "P20607" }, { "db_name": "UniProt", "db_id": "P26892" }, { "db_name": "UniProt", "db_id": "P26893" }, { "db_name": "UniProt", "db_id": "P29455" }, { "db_name": "UniProt", "db_id": "P41323" }, { "db_name": "UniProt", "db_id": "P41683" }, { "db_name": "UniProt", "db_id": "P41693" }, { "db_name": "UniProt", "db_id": "P46650" }, { "db_name": "UniProt", "db_id": "P51494" }, { "db_name": "UniProt", "db_id": "P79341" }, { "db_name": "UniProt", "db_id": "Q25BC2" }, { "db_name": "UniProt", "db_id": "Q28319" }, { "db_name": "UniProt", "db_id": "Q28747" }, { "db_name": "UniProt", "db_id": "Q28819" }, { "db_name": "UniProt", "db_id": "Q2MH06" }, { "db_name": "UniProt", "db_id": "Q5I6E3" }, { "db_name": "UniProt", "db_id": "Q6V919" }, { "db_name": "UniProt", "db_id": "Q865W7" }, { "db_name": "UniProt", "db_id": "Q865X6" }, { "db_name": "UniProt", "db_id": "Q8MKH0" }, { "db_name": "UniProt", "db_id": "Q95181" }, { "db_name": "UniProt", "db_id": "Q9MZR1" }, { "db_name": "UniProt", "db_id": "Q9XT80" } ] }, { "id": "DS.d952.s3.e3", "type": "protein", "text": [ "CRP" ], "offsets": [ [ 488, 491 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19062" }, { "db_name": "UniProt", "db_id": "P02741" }, { "db_name": "UniProt", "db_id": "P02742" }, { "db_name": "UniProt", "db_id": "P08462" }, { "db_name": "UniProt", "db_id": "P18151" }, { "db_name": "UniProt", "db_id": "P21291" }, { "db_name": "UniProt", "db_id": "P41964" }, { "db_name": "UniProt", "db_id": "P47875" }, { "db_name": "UniProt", "db_id": "P49254" }, { "db_name": "UniProt", "db_id": "P49262" }, { "db_name": "UniProt", "db_id": "P52753" }, { "db_name": "UniProt", "db_id": "P67966" }, { "db_name": "UniProt", "db_id": "P67967" }, { "db_name": "UniProt", "db_id": "P97315" }, { "db_name": "UniProt", "db_id": "Q07203" } ] } ]
[]
[]
[]
DS.d953
18757097
[ { "id": "DS.d953.s0", "type": "", "text": [ "Human skin keratinocytes HaCat attacked by Staphylococcus aureus alpha-toxin showed a transient drop of cellular ATP levels whereas in toxin-perforated bovine mammary epithelial cells (BMEC), the ATP levels dropped more slowly." ], "offsets": [ [ 0, 227 ] ] } ]
[ { "id": "DS.d953.s0.e0", "type": "protein", "text": [ "alpha-toxin" ], "offsets": [ [ 65, 76 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P09616" }, { "db_name": "UniProt", "db_id": "P0C216" }, { "db_name": "UniProt", "db_id": "Q0TV31" }, { "db_name": "UniProt", "db_id": "Q9RF12" } ] }, { "id": "DS.d953.s0.e1", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 113, 116 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] }, { "id": "DS.d953.s0.e2", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 196, 199 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] } ]
[]
[]
[ { "id": "DS.d953.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d953.s0.e1", "arg2_id": "DS.d953.s0.e0", "normalized": [] } ]
DS.d954
18757185
[ { "id": "DS.d954.s0", "type": "", "text": [ "Catalepsy, serum prolactin, receptor binding profile and cortical (PFC), hippocampal (Hip) and dopamine (DA) levels were determined." ], "offsets": [ [ 0, 132 ] ] } ]
[ { "id": "DS.d954.s0.e0", "type": "protein", "text": [ "prolactin" ], "offsets": [ [ 17, 26 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10765" }, { "db_name": "UniProt", "db_id": "P22393" }, { "db_name": "UniProt", "db_id": "P33089" }, { "db_name": "UniProt", "db_id": "P33090" }, { "db_name": "UniProt", "db_id": "P33091" }, { "db_name": "UniProt", "db_id": "P43001" } ] }, { "id": "DS.d954.s0.e1", "type": "compound", "text": [ "dopamine" ], "offsets": [ [ 95, 103 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "681" } ] } ]
[]
[]
[]
DS.d955
18757188
[ { "id": "DS.d955.s0", "type": "", "text": [ "Estrogenic effect was determined by the change of uterine weight, and oxidant effects were determined by the content of SOD, GSH-Px, CAT and MDA." ], "offsets": [ [ 0, 145 ] ] }, { "id": "DS.d955.s1", "type": "", "text": [ "The intake of formononetin increased the uterine weight of the mice significantly as well as the content of SOD, GSH-Px, CAT, and reduced MDA in body." ], "offsets": [ [ 146, 296 ] ] } ]
[ { "id": "DS.d955.s0.e0", "type": "protein", "text": [ "SOD" ], "offsets": [ [ 120, 123 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12933" }, { "db_name": "UniProt", "db_id": "O22668" }, { "db_name": "UniProt", "db_id": "O75007" }, { "db_name": "UniProt", "db_id": "P24705" }, { "db_name": "UniProt", "db_id": "P51547" }, { "db_name": "UniProt", "db_id": "P93258" }, { "db_name": "UniProt", "db_id": "Q01137" }, { "db_name": "UniProt", "db_id": "Q27666" }, { "db_name": "UniProt", "db_id": "Q9SM64" } ] }, { "id": "DS.d955.s0.e1", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 125, 128 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d955.s0.e2", "type": "protein", "text": [ "CAT" ], "offsets": [ [ 133, 136 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P00485" }, { "db_name": "UniProt", "db_id": "P00486" }, { "db_name": "UniProt", "db_id": "P00487" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P06135" }, { "db_name": "UniProt", "db_id": "P07641" }, { "db_name": "UniProt", "db_id": "P11504" }, { "db_name": "UniProt", "db_id": "P20074" }, { "db_name": "UniProt", "db_id": "P22782" }, { "db_name": "UniProt", "db_id": "P25309" }, { "db_name": "UniProt", "db_id": "P25819" }, { "db_name": "UniProt", "db_id": "P26825" }, { "db_name": "UniProt", "db_id": "P26826" }, { "db_name": "UniProt", "db_id": "P32796" }, { "db_name": "UniProt", "db_id": "P36882" }, { "db_name": "UniProt", "db_id": "P36883" }, { "db_name": "UniProt", "db_id": "P43155" }, { "db_name": "UniProt", "db_id": "P47934" }, { "db_name": "UniProt", "db_id": "P49417" }, { "db_name": "UniProt", "db_id": "P52826" }, { "db_name": "UniProt", "db_id": "P58777" }, { "db_name": "UniProt", "db_id": "P62577" }, { "db_name": "UniProt", "db_id": "P62578" }, { "db_name": "UniProt", "db_id": "P62579" }, { "db_name": "UniProt", "db_id": "P62580" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q00614" }, { "db_name": "UniProt", "db_id": "Q02736" }, { "db_name": "UniProt", "db_id": "Q03058" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q704S8" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PWF7" } ] }, { "id": "DS.d955.s1.e0", "type": "protein", "text": [ "SOD" ], "offsets": [ [ 254, 257 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12933" }, { "db_name": "UniProt", "db_id": "O22668" }, { "db_name": "UniProt", "db_id": "O75007" }, { "db_name": "UniProt", "db_id": "P24705" }, { "db_name": "UniProt", "db_id": "P51547" }, { "db_name": "UniProt", "db_id": "P93258" }, { "db_name": "UniProt", "db_id": "Q01137" }, { "db_name": "UniProt", "db_id": "Q27666" }, { "db_name": "UniProt", "db_id": "Q9SM64" } ] }, { "id": "DS.d955.s1.e1", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 259, 262 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d955.s1.e2", "type": "protein", "text": [ "CAT" ], "offsets": [ [ 267, 270 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P00485" }, { "db_name": "UniProt", "db_id": "P00486" }, { "db_name": "UniProt", "db_id": "P00487" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P06135" }, { "db_name": "UniProt", "db_id": "P07641" }, { "db_name": "UniProt", "db_id": "P11504" }, { "db_name": "UniProt", "db_id": "P20074" }, { "db_name": "UniProt", "db_id": "P22782" }, { "db_name": "UniProt", "db_id": "P25309" }, { "db_name": "UniProt", "db_id": "P25819" }, { "db_name": "UniProt", "db_id": "P26825" }, { "db_name": "UniProt", "db_id": "P26826" }, { "db_name": "UniProt", "db_id": "P32796" }, { "db_name": "UniProt", "db_id": "P36882" }, { "db_name": "UniProt", "db_id": "P36883" }, { "db_name": "UniProt", "db_id": "P43155" }, { "db_name": "UniProt", "db_id": "P47934" }, { "db_name": "UniProt", "db_id": "P49417" }, { "db_name": "UniProt", "db_id": "P52826" }, { "db_name": "UniProt", "db_id": "P58777" }, { "db_name": "UniProt", "db_id": "P62577" }, { "db_name": "UniProt", "db_id": "P62578" }, { "db_name": "UniProt", "db_id": "P62579" }, { "db_name": "UniProt", "db_id": "P62580" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q00614" }, { "db_name": "UniProt", "db_id": "Q02736" }, { "db_name": "UniProt", "db_id": "Q03058" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q704S8" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PWF7" } ] } ]
[]
[]
[]
DS.d956
18757189
[ { "id": "DS.d956.s0", "type": "", "text": [ "A novel sialic acid-specific lectin from Phaseolus coccineus seeds with potent antineoplastic and antifungal activities." ], "offsets": [ [ 0, 120 ] ] }, { "id": "DS.d956.s1", "type": "", "text": [ "A novel lectin (PCL) with specificity towards sialic acid was purified from Phaseolus coccineus L. (P. multiflorus willd) seeds using ion exchange chromatography on CM and DEAE-Sepharose, and gel filtration on Sephacryl S-200 column." ], "offsets": [ [ 121, 354 ] ] } ]
[ { "id": "DS.d956.s0.e0", "type": "compound", "text": [ "sialic acid" ], "offsets": [ [ 8, 19 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "906" }, { "db_name": "PubChem", "db_id": "444885" }, { "db_name": "PubChem", "db_id": "445063" } ] }, { "id": "DS.d956.s0.e1", "type": "protein", "text": [ "lectin" ], "offsets": [ [ 29, 35 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02871" }, { "db_name": "UniProt", "db_id": "P02873" }, { "db_name": "UniProt", "db_id": "P02874" }, { "db_name": "UniProt", "db_id": "P02875" }, { "db_name": "UniProt", "db_id": "P07386" }, { "db_name": "UniProt", "db_id": "P16108" }, { "db_name": "UniProt", "db_id": "P16349" }, { "db_name": "UniProt", "db_id": "P16351" }, { "db_name": "UniProt", "db_id": "P16352" }, { "db_name": "UniProt", "db_id": "P33888" }, { "db_name": "UniProt", "db_id": "P38662" }, { "db_name": "UniProt", "db_id": "P42088" }, { "db_name": "UniProt", "db_id": "P83410" }, { "db_name": "UniProt", "db_id": "P83511" }, { "db_name": "UniProt", "db_id": "P84987" }, { "db_name": "UniProt", "db_id": "Q41114" } ] }, { "id": "DS.d956.s1.e0", "type": "protein", "text": [ "lectin" ], "offsets": [ [ 129, 135 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02871" }, { "db_name": "UniProt", "db_id": "P02873" }, { "db_name": "UniProt", "db_id": "P02874" }, { "db_name": "UniProt", "db_id": "P02875" }, { "db_name": "UniProt", "db_id": "P07386" }, { "db_name": "UniProt", "db_id": "P16108" }, { "db_name": "UniProt", "db_id": "P16349" }, { "db_name": "UniProt", "db_id": "P16351" }, { "db_name": "UniProt", "db_id": "P16352" }, { "db_name": "UniProt", "db_id": "P33888" }, { "db_name": "UniProt", "db_id": "P38662" }, { "db_name": "UniProt", "db_id": "P42088" }, { "db_name": "UniProt", "db_id": "P83410" }, { "db_name": "UniProt", "db_id": "P83511" }, { "db_name": "UniProt", "db_id": "P84987" }, { "db_name": "UniProt", "db_id": "Q41114" } ] }, { "id": "DS.d956.s1.e1", "type": "compound", "text": [ "sialic acid" ], "offsets": [ [ 167, 178 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "906" }, { "db_name": "PubChem", "db_id": "444885" }, { "db_name": "PubChem", "db_id": "445063" } ] } ]
[]
[]
[ { "id": "DS.d956.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d956.s0.e0", "arg2_id": "DS.d956.s0.e1", "normalized": [] }, { "id": "DS.d956.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d956.s1.e1", "arg2_id": "DS.d956.s1.e0", "normalized": [] } ]
DS.d957
18757233
[ { "id": "DS.d957.s0", "type": "", "text": [ "The characterization for the binding of calcium and terbium to Euplotes octocarinatus centrin." ], "offsets": [ [ 0, 94 ] ] } ]
[ { "id": "DS.d957.s0.e0", "type": "compound", "text": [ "terbium" ], "offsets": [ [ 52, 59 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23958" } ] }, { "id": "DS.d957.s0.e1", "type": "protein", "text": [ "centrin" ], "offsets": [ [ 86, 93 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05434" }, { "db_name": "UniProt", "db_id": "P41210" }, { "db_name": "UniProt", "db_id": "P43645" }, { "db_name": "UniProt", "db_id": "P43646" }, { "db_name": "UniProt", "db_id": "P53441" }, { "db_name": "UniProt", "db_id": "P54213" }, { "db_name": "UniProt", "db_id": "Q06827" }, { "db_name": "UniProt", "db_id": "Q24956" }, { "db_name": "UniProt", "db_id": "Q27177" }, { "db_name": "UniProt", "db_id": "Q27178" }, { "db_name": "UniProt", "db_id": "Q27179" } ] } ]
[]
[]
[ { "id": "DS.d957.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d957.s0.e0", "arg2_id": "DS.d957.s0.e1", "normalized": [] } ]
DS.d958
18757307
[ { "id": "DS.d958.s0", "type": "", "text": [ "We have previously shown that ROS-induced MUC5AC expression in NHBE cells is dependent on hyaluronan depolymerization and epidermal growth factor receptor (EGFR)/mitogen-activated protein kinase (MAPK) activation." ], "offsets": [ [ 0, 213 ] ] } ]
[ { "id": "DS.d958.s0.e0", "type": "protein", "text": [ "MUC5AC" ], "offsets": [ [ 42, 48 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P98088" } ] }, { "id": "DS.d958.s0.e1", "type": "compound", "text": [ "hyaluronan" ], "offsets": [ [ 90, 100 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24759" } ] }, { "id": "DS.d958.s0.e2", "type": "protein", "text": [ "epidermal growth factor receptor" ], "offsets": [ [ 122, 154 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P55245" } ] }, { "id": "DS.d958.s0.e3", "type": "protein", "text": [ "EGFR" ], "offsets": [ [ 156, 160 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00533" }, { "db_name": "UniProt", "db_id": "P13387" }, { "db_name": "UniProt", "db_id": "P55245" } ] }, { "id": "DS.d958.s0.e4", "type": "protein", "text": [ "mitogen-activated protein kinase" ], "offsets": [ [ 162, 194 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q00859" } ] }, { "id": "DS.d958.s0.e5", "type": "protein", "text": [ "MAPK" ], "offsets": [ [ 196, 200 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42781" }, { "db_name": "UniProt", "db_id": "P27638" }, { "db_name": "UniProt", "db_id": "Q00859" } ] } ]
[]
[]
[ { "id": "DS.d958.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d958.s0.e1", "arg2_id": "DS.d958.s0.e0", "normalized": [] } ]
DS.d959
18757495
[ { "id": "DS.d959.s0", "type": "", "text": [ "Alkaline phosphatase activity and osteonectin expression of the osteoblasts cultured on the PLGA scaffolds remained stable over three weeks, whilst expression of collagen type I and osteopontin decreased." ], "offsets": [ [ 0, 204 ] ] }, { "id": "DS.d959.s1", "type": "", "text": [ "The alkaline phosphatase activity of osteoblasts cultured on PLGA scaffolds is comparable with that from two commercially-available scaffolds-OPLA and collagen scaffolds (Becton-Dickinson (BD) Inc., Franklin Lakes, NJ, USA)." ], "offsets": [ [ 205, 429 ] ] } ]
[ { "id": "DS.d959.s0.e0", "type": "protein", "text": [ "Alkaline phosphatase" ], "offsets": [ [ 0, 20 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60109" }, { "db_name": "UniProt", "db_id": "P81800" }, { "db_name": "UniProt", "db_id": "P83456" } ] }, { "id": "DS.d959.s0.e1", "type": "protein", "text": [ "osteonectin" ], "offsets": [ [ 34, 45 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O93390" }, { "db_name": "UniProt", "db_id": "P07214" }, { "db_name": "UniProt", "db_id": "P09486" }, { "db_name": "UniProt", "db_id": "P13213" }, { "db_name": "UniProt", "db_id": "P16975" }, { "db_name": "UniProt", "db_id": "P20112" }, { "db_name": "UniProt", "db_id": "P34714" }, { "db_name": "UniProt", "db_id": "P36233" }, { "db_name": "UniProt", "db_id": "P36377" }, { "db_name": "UniProt", "db_id": "P36378" }, { "db_name": "UniProt", "db_id": "P36379" } ] }, { "id": "DS.d959.s0.e2", "type": "compound", "text": [ "PLGA" ], "offsets": [ [ 92, 96 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "36797" } ] }, { "id": "DS.d959.s1.e0", "type": "protein", "text": [ "alkaline phosphatase" ], "offsets": [ [ 209, 229 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60109" }, { "db_name": "UniProt", "db_id": "P81800" }, { "db_name": "UniProt", "db_id": "P83456" } ] }, { "id": "DS.d959.s1.e1", "type": "compound", "text": [ "PLGA" ], "offsets": [ [ 266, 270 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "36797" } ] } ]
[]
[]
[]
DS.d960
18757514
[ { "id": "DS.d960.s0", "type": "", "text": [ "The vasodilating effect of acetazolamide and dorzolamide involves mechanisms other than carbonic anhydrase inhibition." ], "offsets": [ [ 0, 118 ] ] } ]
[ { "id": "DS.d960.s0.e0", "type": "compound", "text": [ "acetazolamide" ], "offsets": [ [ 27, 40 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1986" } ] }, { "id": "DS.d960.s0.e1", "type": "compound", "text": [ "dorzolamide" ], "offsets": [ [ 45, 56 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5284549" } ] }, { "id": "DS.d960.s0.e2", "type": "protein", "text": [ "carbonic anhydrase" ], "offsets": [ [ 88, 106 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27134" }, { "db_name": "UniProt", "db_id": "P46281" }, { "db_name": "UniProt", "db_id": "P46510" }, { "db_name": "UniProt", "db_id": "P46511" }, { "db_name": "UniProt", "db_id": "P54212" }, { "db_name": "UniProt", "db_id": "P84537" }, { "db_name": "UniProt", "db_id": "Q54735" }, { "db_name": "UniProt", "db_id": "Q92051" }, { "db_name": "UniProt", "db_id": "Q9ZN54" } ] } ]
[]
[]
[]
DS.d961
18757837
[ { "id": "DS.d961.s0", "type": "", "text": [ "The objective of the present study was to investigate the effects of a high-cholesterol diet on caveolin-1 expression and IR localization and activity in the rat liver." ], "offsets": [ [ 0, 168 ] ] } ]
[ { "id": "DS.d961.s0.e0", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 76, 87 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d961.s0.e1", "type": "protein", "text": [ "caveolin-1" ], "offsets": [ [ 96, 106 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P33724" }, { "db_name": "UniProt", "db_id": "P35431" }, { "db_name": "UniProt", "db_id": "P41350" }, { "db_name": "UniProt", "db_id": "P49817" }, { "db_name": "UniProt", "db_id": "P79132" }, { "db_name": "UniProt", "db_id": "Q03135" }, { "db_name": "UniProt", "db_id": "Q07DV9" }, { "db_name": "UniProt", "db_id": "Q07DX1" }, { "db_name": "UniProt", "db_id": "Q07DY2" }, { "db_name": "UniProt", "db_id": "Q07DZ2" }, { "db_name": "UniProt", "db_id": "Q07E02" }, { "db_name": "UniProt", "db_id": "Q07E25" }, { "db_name": "UniProt", "db_id": "Q07E38" }, { "db_name": "UniProt", "db_id": "Q07E49" }, { "db_name": "UniProt", "db_id": "Q09YH8" }, { "db_name": "UniProt", "db_id": "Q09YK1" }, { "db_name": "UniProt", "db_id": "Q09YN6" }, { "db_name": "UniProt", "db_id": "Q108U7" }, { "db_name": "UniProt", "db_id": "Q2IBA5" }, { "db_name": "UniProt", "db_id": "Q2IBC1" }, { "db_name": "UniProt", "db_id": "Q2IBD7" }, { "db_name": "UniProt", "db_id": "Q2IBF0" }, { "db_name": "UniProt", "db_id": "Q2IBG8" }, { "db_name": "UniProt", "db_id": "Q2QL79" }, { "db_name": "UniProt", "db_id": "Q2QL90" }, { "db_name": "UniProt", "db_id": "Q2QLB0" }, { "db_name": "UniProt", "db_id": "Q2QLC1" }, { "db_name": "UniProt", "db_id": "Q2QLF2" }, { "db_name": "UniProt", "db_id": "Q2QLG6" }, { "db_name": "UniProt", "db_id": "Q2QLH7" }, { "db_name": "UniProt", "db_id": "Q6B3Y2" }, { "db_name": "UniProt", "db_id": "Q6RVA9" }, { "db_name": "UniProt", "db_id": "Q94051" }, { "db_name": "UniProt", "db_id": "Q9YGM8" } ] } ]
[]
[]
[ { "id": "DS.d961.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d961.s0.e0", "arg2_id": "DS.d961.s0.e1", "normalized": [] } ]
DS.d962
18758183
[ { "id": "DS.d962.s0", "type": "", "text": [ "P27 and P53 play important roles in the signal transduction leading to neointimal growth inhibition and induction of apoptosis of smooth muscle cells due to rapamycin and paclitaxel." ], "offsets": [ [ 0, 182 ] ] } ]
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171, 181 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4666" }, { "db_name": "PubChem", "db_id": "36314" }, { "db_name": "PubChem", "db_id": "441276" }, { "db_name": "PubChem", "db_id": "5352019" }, { "db_name": "PubChem", "db_id": "6713921" }, { "db_name": "PubChem", "db_id": "6915727" }, { "db_name": "PubChem", "db_id": "44155032" }, { "db_name": "PubChem", "db_id": "53313247" } ] } ]
[]
[]
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DS.d963
18758695
[ { "id": "DS.d963.s0", "type": "", "text": [ "Immobilization of hemoglobin on the gold colloid modified pretreated glassy carbon electrode for preparing a novel hydrogen peroxide biosensor." ], "offsets": [ [ 0, 143 ] ] }, { "id": "DS.d963.s1", "type": "", "text": [ "A novel hydrogen peroxide (H2O2) biosensor was developed by immobilizing hemoglobin on the gold colloid modified electrochemical pretreated glassy carbon electrode (PGCE) via the bridging of an ethylenediamine monolayer." ], "offsets": [ [ 144, 364 ] ] } ]
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[]
[]
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DS.d964
18758751
[ { "id": "DS.d964.s0", "type": "", "text": [ "Involvement of PKC in TPA-potentiated apoptosis induction during hemin-mediated erythroid differentiation in K562 cells." ], "offsets": [ [ 0, 120 ] ] }, { "id": "DS.d964.s1", "type": "", "text": [ "To better understand the mechanisms underlying differentiation-mediated regulation of apoptosis, we have studied the effects of PKC pathway with an activator of the protein kinase C, 12-O-tetradecanoylphorbol-13-acetate (TPA), during hemin-induced erythroid differentiation of K562 erythroleukemia cells." ], "offsets": [ [ 121, 425 ] ] }, { "id": "DS.d964.s2", "type": "", "text": [ "Taken together, our results suggested the involvement of PKC in TPA-potentiated apoptosis induction during hemin-mediated erythroid differentiation in K562 cells." ], "offsets": [ [ 426, 588 ] ] } ]
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[]
[]
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DS.d965
18758757
[ { "id": "DS.d965.s0", "type": "", "text": [ "At glutamatergic synapses, increased binding to the glycine-B site located in the N-methyl-D-aspartate receptor (NMDAR) can enhance neurotransmission via NMDARs." ], "offsets": [ [ 0, 161 ] ] } ]
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[]
[]
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DS.d966
18758781
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[]
[]
[]
DS.d967
18758819
[ { "id": "DS.d967.s0", "type": "", "text": [ "In vitro effect of radiation, antibody to epidermal growth factor receptor and Docetaxel in human head and neck squamous carcinoma cells with mutant P53 and over-expressed EGFR." ], "offsets": [ [ 0, 177 ] ] } ]
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[]
[]
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DS.d968
18758925
[ { "id": "DS.d968.s0", "type": "", "text": [ "The optimal condition for the labeling of cypate to L-ASNase was 4 h reaction duration at 4 degrees C and pH 8.5 under catalysis by HOBt/HBTU." ], "offsets": [ [ 0, 142 ] ] } ]
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[]
[]
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DS.d969
18758938
[ { "id": "DS.d969.s0", "type": "", "text": [ "Effects of insulin and ascorbic acid on expression of Bcl-2 family proteins and caspase-3 activity in hippocampus of diabetic rats were evaluated in this study." ], "offsets": [ [ 0, 160 ] ] } ]
[ { "id": "DS.d969.s0.e0", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 11, 18 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d969.s0.e1", "type": "compound", "text": [ "ascorbic acid" ], "offsets": [ [ 23, 36 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54670067" }, { "db_name": "PubChem", "db_id": "54690394" } ] }, { "id": "DS.d969.s0.e2", "type": "protein", "text": [ "Bcl-2" ], "offsets": [ [ 54, 59 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10417" }, { "db_name": "UniProt", "db_id": "P49950" } ] } ]
[]
[]
[ { "id": "DS.d969.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d969.s0.e1", "arg2_id": "DS.d969.s0.e2", "normalized": [] } ]
DS.d970
18758940
[ { "id": "DS.d970.s0", "type": "", "text": [ "Chemo-enzymatic synthesis of poly-N-acetyllactosamine (poly-LacNAc) structures and their characterization for CGL2-galectin-mediated binding of ECM glycoproteins to biomaterial surfaces." ], "offsets": [ [ 0, 186 ] ] }, { "id": "DS.d970.s1", "type": "", "text": [ "Poly-N-acetyllactosamine (poly-LacNAc) structures have been identified as important ligands for galectin-mediated cell adhesion to extra-cellular matrix (ECM) proteins." ], "offsets": [ [ 187, 355 ] ] }, { "id": "DS.d970.s2", "type": "", "text": [ "We here present the biofunctionalization of surfaces with poly-LacNAc structures and subsequent binding of ECM glycoproteins." ], "offsets": [ [ 356, 481 ] ] }, { "id": "DS.d970.s3", "type": "", "text": [ "A mixture of poly-LacNAc-structures covalently coupled to functionalized microtiter plates were identified for best binding to our model galectin His(6) CGL2." ], "offsets": [ [ 482, 640 ] ] }, { "id": "DS.d970.s4", "type": "", "text": [ "We further demonstrate for the first time that these poly-LacNAc surfaces are suitable for further galectin-mediated binding of the ECM glycoproteins laminin and fibronectin." ], "offsets": [ [ 641, 815 ] ] } ]
[ { "id": "DS.d970.s0.e0", "type": "compound", "text": [ "poly-N-acetyllactosamine" ], "offsets": [ [ 29, 53 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "119547" } ] }, { "id": "DS.d970.s0.e1", "type": "compound", "text": [ "LacNAc" ], "offsets": [ [ 60, 66 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16760443" } ] }, { "id": "DS.d970.s0.e2", "type": "protein", "text": [ "CGL2" ], "offsets": [ [ 110, 114 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20718" } ] }, { "id": "DS.d970.s0.e3", "type": "protein", "text": [ "galectin" ], "offsets": [ [ 115, 123 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q801X7" } ] }, { "id": "DS.d970.s0.e4", "type": "protein", "text": [ "glycoproteins" ], "offsets": [ [ 148, 161 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08163" } ] }, { "id": "DS.d970.s1.e0", "type": "compound", "text": [ "Poly-N-acetyllactosamine" ], "offsets": [ [ 187, 211 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "119547" } ] }, { "id": "DS.d970.s1.e1", "type": "compound", "text": [ "LacNAc" ], "offsets": [ [ 218, 224 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16760443" } ] }, { "id": "DS.d970.s1.e2", "type": "protein", "text": [ "galectin" ], "offsets": [ [ 283, 291 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q801X7" } ] }, { "id": "DS.d970.s2.e0", "type": "compound", "text": [ "LacNAc" ], "offsets": [ [ 419, 425 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16760443" } ] }, { "id": "DS.d970.s2.e1", "type": "protein", "text": [ "glycoproteins" ], "offsets": [ [ 467, 480 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08163" } ] }, { "id": "DS.d970.s3.e0", "type": "compound", "text": [ "LacNAc" ], "offsets": [ [ 500, 506 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16760443" } ] }, { "id": "DS.d970.s3.e1", "type": "protein", "text": [ "galectin" ], "offsets": [ [ 619, 627 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q801X7" } ] }, { "id": "DS.d970.s3.e2", "type": "protein", "text": [ "CGL2" ], "offsets": [ [ 635, 639 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20718" } ] }, { "id": "DS.d970.s4.e0", "type": "compound", "text": [ "LacNAc" ], "offsets": [ [ 699, 705 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "16760443" } ] }, { "id": "DS.d970.s4.e1", "type": "protein", "text": [ "galectin" ], "offsets": [ [ 740, 748 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q801X7" } ] }, { "id": "DS.d970.s4.e2", "type": "protein", "text": [ "ECM" ], "offsets": [ [ 773, 776 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q13201" } ] }, { "id": "DS.d970.s4.e3", "type": "protein", "text": [ "glycoproteins" ], "offsets": [ [ 777, 790 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08163" } ] }, { "id": "DS.d970.s4.e5", "type": "protein", "text": [ "fibronectin" ], "offsets": [ [ 803, 814 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07589" }, { "db_name": "UniProt", "db_id": "P11722" }, { "db_name": "UniProt", "db_id": "Q28275" }, { "db_name": "UniProt", "db_id": "Q28377" }, { "db_name": "UniProt", "db_id": "Q28749" }, { "db_name": "UniProt", "db_id": "Q91289" }, { "db_name": "UniProt", "db_id": "Q91400" } ] } ]
[]
[]
[ { "id": "DS.d970.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d970.s0.e1", "arg2_id": "DS.d970.s0.e2", "normalized": [] }, { "id": "DS.d970.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d970.s0.e0", "arg2_id": "DS.d970.s0.e3", "normalized": [] }, { "id": "DS.d970.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d970.s0.e1", "arg2_id": "DS.d970.s0.e3", "normalized": [] }, { "id": "DS.d970.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d970.s0.e0", "arg2_id": "DS.d970.s0.e2", "normalized": [] }, { "id": "DS.d970.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d970.s0.e1", "arg2_id": "DS.d970.s0.e4", "normalized": [] }, { "id": "DS.d970.s0.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d970.s0.e0", "arg2_id": "DS.d970.s0.e4", "normalized": [] }, { "id": "DS.d970.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d970.s1.e0", "arg2_id": "DS.d970.s1.e2", "normalized": [] }, { "id": "DS.d970.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d970.s1.e1", "arg2_id": "DS.d970.s1.e2", "normalized": [] }, { "id": "DS.d970.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d970.s2.e0", "arg2_id": "DS.d970.s2.e1", "normalized": [] }, { "id": "DS.d970.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d970.s3.e0", "arg2_id": "DS.d970.s3.e2", "normalized": [] }, { "id": "DS.d970.s3.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d970.s3.e0", "arg2_id": "DS.d970.s3.e1", "normalized": [] }, { "id": "DS.d970.s4.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d970.s4.e0", "arg2_id": "DS.d970.s4.e1", "normalized": [] }, { "id": "DS.d970.s4.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d970.s4.e0", "arg2_id": "DS.d970.s4.e5", "normalized": [] }, { "id": "DS.d970.s4.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d970.s4.e0", "arg2_id": "DS.d970.s4.e3", "normalized": [] }, { "id": "DS.d970.s4.i6", "type": "compound-protein-interaction", "arg1_id": "DS.d970.s4.e0", "arg2_id": "DS.d970.s4.e2", "normalized": [] } ]
DS.d971
18758978
[ { "id": "DS.d971.s0", "type": "", "text": [ "Seasonal variation of the metal (Zn, Fe, Mn) and metallothionein concentrations in the liver cytosol of the European chub (Squalius cephalus L.)." ], "offsets": [ [ 0, 145 ] ] }, { "id": "DS.d971.s1", "type": "", "text": [ "The specimens caught in the spring period had higher biometric (liver mass, condition and hepatosomatic indices) and some biochemical parameters (metallothionein (MT) and Mn) that are characteristic for the reproductive period." ], "offsets": [ [ 146, 373 ] ] } ]
[ { "id": "DS.d971.s0.e0", "type": "compound", "text": [ "Mn" ], "offsets": [ [ 41, 43 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23930" } ] }, { "id": "DS.d971.s0.e1", "type": "protein", "text": [ "metallothionein" ], "offsets": [ [ 49, 64 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02033" }, { "db_name": "UniProt", "db_id": "O13257" }, { "db_name": "UniProt", "db_id": "O18842" }, { "db_name": "UniProt", "db_id": "O42152" }, { "db_name": "UniProt", "db_id": "O93571" }, { "db_name": "UniProt", "db_id": "P02807" }, { "db_name": "UniProt", "db_id": "P04358" }, { "db_name": "UniProt", "db_id": "P07216" }, { "db_name": "UniProt", "db_id": "P08002" }, { "db_name": "UniProt", "db_id": "P23038" }, { "db_name": "UniProt", "db_id": "P25127" }, { "db_name": "UniProt", "db_id": "P25128" }, { "db_name": "UniProt", "db_id": "P30331" }, { "db_name": "UniProt", "db_id": "P30565" }, { "db_name": "UniProt", "db_id": "P51902" }, { "db_name": "UniProt", "db_id": "P52723" }, { "db_name": "UniProt", "db_id": "P52725" }, { "db_name": "UniProt", "db_id": "P52726" }, { "db_name": "UniProt", "db_id": "P52728" }, { "db_name": "UniProt", "db_id": "P55945" }, { "db_name": "UniProt", "db_id": "P55946" }, { "db_name": "UniProt", "db_id": "P55948" }, { "db_name": "UniProt", "db_id": "P55951" }, { "db_name": "UniProt", "db_id": "P55952" }, { "db_name": "UniProt", "db_id": "P55953" }, { "db_name": "UniProt", "db_id": "P68494" }, { "db_name": "UniProt", "db_id": "P68495" }, { "db_name": "UniProt", "db_id": "P68497" }, { "db_name": "UniProt", "db_id": "P68498" }, { "db_name": "UniProt", "db_id": "P68499" }, { "db_name": "UniProt", "db_id": "P80367" }, { "db_name": "UniProt", "db_id": "P80593" }, { "db_name": "UniProt", "db_id": "P84865" }, { "db_name": "UniProt", "db_id": "Q05890" }, { "db_name": "UniProt", "db_id": "Q6J1T3" }, { "db_name": "UniProt", "db_id": "Q6S4N8" }, { "db_name": "UniProt", "db_id": "Q6XUW5" }, { "db_name": "UniProt", "db_id": "Q708T3" }, { "db_name": "UniProt", "db_id": "Q7ZZP9" }, { "db_name": "UniProt", "db_id": "Q800D3" }, { "db_name": "UniProt", "db_id": "Q8UVY1" }, { "db_name": "UniProt", "db_id": "Q94550" }, { "db_name": "UniProt", "db_id": "Q9IB50" }, { "db_name": "UniProt", "db_id": "Q9U568" } ] }, { "id": "DS.d971.s1.e0", "type": "protein", "text": [ "metallothionein" ], "offsets": [ [ 292, 307 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02033" }, { "db_name": "UniProt", "db_id": "O13257" }, { "db_name": "UniProt", "db_id": "O18842" }, { "db_name": "UniProt", "db_id": "O42152" }, { "db_name": "UniProt", "db_id": "O93571" }, { "db_name": "UniProt", "db_id": "P02807" }, { "db_name": "UniProt", "db_id": "P04358" }, { "db_name": "UniProt", "db_id": "P07216" }, { "db_name": "UniProt", "db_id": "P08002" }, { "db_name": "UniProt", "db_id": "P23038" }, { "db_name": "UniProt", "db_id": "P25127" }, { "db_name": "UniProt", "db_id": "P25128" }, { "db_name": "UniProt", "db_id": "P30331" }, { "db_name": "UniProt", "db_id": "P30565" }, { "db_name": "UniProt", "db_id": "P51902" }, { "db_name": "UniProt", "db_id": "P52723" }, { "db_name": "UniProt", "db_id": "P52725" }, { "db_name": "UniProt", "db_id": "P52726" }, { "db_name": "UniProt", "db_id": "P52728" }, { "db_name": "UniProt", "db_id": "P55945" }, { "db_name": "UniProt", "db_id": "P55946" }, { "db_name": "UniProt", "db_id": "P55948" }, { "db_name": "UniProt", "db_id": "P55951" }, { "db_name": "UniProt", "db_id": "P55952" }, { "db_name": "UniProt", "db_id": "P55953" }, { "db_name": "UniProt", "db_id": "P68494" }, { "db_name": "UniProt", "db_id": "P68495" }, { "db_name": "UniProt", "db_id": "P68497" }, { "db_name": "UniProt", "db_id": "P68498" }, { "db_name": "UniProt", "db_id": "P68499" }, { "db_name": "UniProt", "db_id": "P80367" }, { "db_name": "UniProt", "db_id": "P80593" }, { "db_name": "UniProt", "db_id": "P84865" }, { "db_name": "UniProt", "db_id": "Q05890" }, { "db_name": "UniProt", "db_id": "Q6J1T3" }, { "db_name": "UniProt", "db_id": "Q6S4N8" }, { "db_name": "UniProt", "db_id": "Q6XUW5" }, { "db_name": "UniProt", "db_id": "Q708T3" }, { "db_name": "UniProt", "db_id": "Q7ZZP9" }, { "db_name": "UniProt", "db_id": "Q800D3" }, { "db_name": "UniProt", "db_id": "Q8UVY1" }, { "db_name": "UniProt", "db_id": "Q94550" }, { "db_name": "UniProt", "db_id": "Q9IB50" }, { "db_name": "UniProt", "db_id": "Q9U568" } ] }, { "id": "DS.d971.s1.e1", "type": "compound", "text": [ "Mn" ], "offsets": [ [ 317, 319 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23930" } ] } ]
[]
[]
[]
DS.d972
18758993
[ { "id": "DS.d972.s0", "type": "", "text": [ "Glutamate decarboxylase (GAD) is the rate-limiting enzyme in the synthesis of gamma-aminobutyric acid (GABA), the most important inhibitory neurotransmitter in central nervous system (CNS)." ], "offsets": [ [ 0, 189 ] ] }, { "id": "DS.d972.s1", "type": "", "text": [ "These transcripts were predicted to synthesis of GAD proteins truncated of the binding site for pyridoxal phosphate, an essential cofactor, therefore cannot function as a decarboxylase." ], "offsets": [ [ 190, 375 ] ] } ]
[ { "id": "DS.d972.s0.e0", "type": "protein", "text": [ "Glutamate decarboxylase" ], "offsets": [ [ 0, 23 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O30418" }, { "db_name": "UniProt", "db_id": "P20228" }, { "db_name": "UniProt", "db_id": "P54767" }, { "db_name": "UniProt", "db_id": "Q04792" }, { "db_name": "UniProt", "db_id": "Q07346" }, { "db_name": "UniProt", "db_id": "Q9CG20" } ] }, { "id": "DS.d972.s0.e1", "type": "protein", "text": [ "GAD" ], "offsets": [ [ 25, 28 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20228" }, { "db_name": "UniProt", "db_id": "P54767" }, { "db_name": "UniProt", "db_id": "Q04792" }, { "db_name": "UniProt", "db_id": "Q07346" }, { "db_name": "UniProt", "db_id": "Q42521" }, { "db_name": "UniProt", "db_id": "Q99259" }, { "db_name": "UniProt", "db_id": "Q9CG20" } ] }, { "id": "DS.d972.s0.e2", "type": "compound", "text": [ "gamma-aminobutyric acid" ], "offsets": [ [ 78, 101 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "119" } ] }, { "id": "DS.d972.s0.e3", "type": "compound", "text": [ "GABA" ], "offsets": [ [ 103, 107 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "119" } ] }, { "id": "DS.d972.s1.e0", "type": "protein", "text": [ "GAD" ], "offsets": [ [ 239, 242 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20228" }, { "db_name": "UniProt", "db_id": "P54767" }, { "db_name": "UniProt", "db_id": "Q04792" }, { "db_name": "UniProt", "db_id": "Q07346" }, { "db_name": "UniProt", "db_id": "Q42521" }, { "db_name": "UniProt", "db_id": "Q99259" }, { "db_name": "UniProt", "db_id": "Q9CG20" } ] }, { "id": "DS.d972.s1.e1", "type": "compound", "text": [ "pyridoxal phosphate" ], "offsets": [ [ 286, 305 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1051" } ] } ]
[]
[]
[ { "id": "DS.d972.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d972.s0.e3", "arg2_id": "DS.d972.s0.e0", "normalized": [] }, { "id": "DS.d972.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d972.s0.e2", "arg2_id": "DS.d972.s0.e1", "normalized": [] }, { "id": "DS.d972.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d972.s0.e3", "arg2_id": "DS.d972.s0.e1", "normalized": [] }, { "id": "DS.d972.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d972.s0.e2", "arg2_id": "DS.d972.s0.e0", "normalized": [] }, { "id": "DS.d972.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d972.s1.e1", "arg2_id": "DS.d972.s1.e0", "normalized": [] } ]
DS.d973
18759148
[ { "id": "DS.d973.s0", "type": "", "text": [ "Loss-of-expression of SSTR2 in tumor tissues has been suggested to correlate with tumor progression and to the relatively poorer outcomes of somatostatin analog treatment in some clinical trials." ], "offsets": [ [ 0, 195 ] ] } ]
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[]
[]
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DS.d974
18760301
[ { "id": "DS.d974.s0", "type": "", "text": [ "Cobra venom factor (CVF) is a structural and functional analog of complement C3 isolated from cobra venom." ], "offsets": [ [ 0, 106 ] ] } ]
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[]
[]
[ { "id": "DS.d974.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d974.s0.e0", "arg2_id": "DS.d974.s0.e1", "normalized": [] } ]
DS.d975
18760497
[ { "id": "DS.d975.s0", "type": "", "text": [ "Activities of malate- and succinate-dehydrogenases (MDH, SDH) and NADH- and succinate-cytochrome c reductases (NCCR, SCCR) were rapidly inhibited, while cytochrome c oxidase (CCO) was unaltered by cadmium treatment." ], "offsets": [ [ 0, 215 ] ] }, { "id": "DS.d975.s1", "type": "", "text": [ "However, this stimulated the NADPH-generating enzyme activities of the pentose phosphate pathway, glucose-6-phosphate- and 6-phosphogluconate-dehydrogenases (G6PDH, 6PGDH), as well as enzyme activity of fermentation, alcohol dehydrogenase (ADH), with concomitant inhibition in the capacity of enzyme inactivator (INADH)." ], "offsets": [ [ 216, 536 ] ] } ]
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"UniProt", "db_id": "P38997" }, { "db_name": "UniProt", "db_id": "P38998" }, { "db_name": "UniProt", "db_id": "P42630" }, { "db_name": "UniProt", "db_id": "P43065" }, { "db_name": "UniProt", "db_id": "P56072" }, { "db_name": "UniProt", "db_id": "P66773" }, { "db_name": "UniProt", "db_id": "P66774" }, { "db_name": "UniProt", "db_id": "P71349" }, { "db_name": "UniProt", "db_id": "P80212" }, { "db_name": "UniProt", "db_id": "P80213" }, { "db_name": "UniProt", "db_id": "Q02912" }, { "db_name": "UniProt", "db_id": "Q09694" }, { "db_name": "UniProt", "db_id": "Q48838" }, { "db_name": "UniProt", "db_id": "Q6FU27" }, { "db_name": "UniProt", "db_id": "Q75BV4" }, { "db_name": "UniProt", "db_id": "Q7SFX6" }, { "db_name": "UniProt", "db_id": "Q870G1" }, { "db_name": "UniProt", "db_id": "Q8LGI2" }, { "db_name": "UniProt", "db_id": "Q99K67" }, { "db_name": "UniProt", "db_id": "Q9SMZ4" }, { "db_name": "UniProt", "db_id": "Q9SQT8" }, { "db_name": "UniProt", "db_id": "Q9UDR5" }, { "db_name": "UniProt", "db_id": "Q9ZMU7" } ] }, { "id": "DS.d975.s0.e4", "type": "compound", "text": [ "cadmium" ], "offsets": [ [ 197, 204 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23973" } ] }, { "id": "DS.d975.s1.e0", "type": "compound", "text": [ "pentose" ], "offsets": [ [ 287, 294 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "854" } ] }, { "id": "DS.d975.s1.e1", "type": "protein", "text": [ "G6PDH" ], "offsets": [ [ 374, 379 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P37830" }, { "db_name": "UniProt", "db_id": "P48826" } ] }, { "id": "DS.d975.s1.e2", "type": "protein", "text": [ "alcohol dehydrogenase" ], "offsets": [ [ 433, 454 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O31186" }, { "db_name": "UniProt", "db_id": "P00332" }, { "db_name": "UniProt", "db_id": "P00334" }, { "db_name": "UniProt", "db_id": "P06525" }, { "db_name": "UniProt", "db_id": "P07159" }, { "db_name": "UniProt", "db_id": "P07162" }, { "db_name": "UniProt", "db_id": "P0A9Q7" }, { "db_name": "UniProt", "db_id": "P0A9Q8" }, { "db_name": "UniProt", "db_id": "P10807" }, { "db_name": "UniProt", "db_id": "P12311" }, { "db_name": "UniProt", "db_id": "P14940" }, { "db_name": "UniProt", "db_id": "P17648" }, { "db_name": "UniProt", "db_id": "P21518" }, { "db_name": "UniProt", "db_id": "P21898" }, { "db_name": "UniProt", "db_id": "P22245" }, { "db_name": "UniProt", "db_id": "P23277" }, { "db_name": "UniProt", "db_id": "P23278" }, { "db_name": "UniProt", "db_id": "P23361" }, { "db_name": "UniProt", "db_id": "P25139" }, { "db_name": "UniProt", "db_id": "P25721" }, { "db_name": "UniProt", "db_id": "P25988" }, { "db_name": "UniProt", "db_id": "P26719" }, { "db_name": "UniProt", "db_id": "P28483" }, { "db_name": "UniProt", "db_id": "P28484" }, { "db_name": "UniProt", "db_id": "P33744" }, { "db_name": "UniProt", "db_id": "P37473" }, { "db_name": "UniProt", "db_id": "P42327" }, { "db_name": "UniProt", "db_id": "P42328" }, { "db_name": "UniProt", "db_id": "P48584" }, { "db_name": "UniProt", "db_id": "P48585" }, { "db_name": "UniProt", "db_id": "P48977" }, { "db_name": "UniProt", "db_id": "P51549" }, { "db_name": "UniProt", "db_id": "P51550" }, { "db_name": "UniProt", "db_id": "P51551" }, { "db_name": "UniProt", "db_id": "P51552" }, { "db_name": "UniProt", "db_id": "P71017" }, { "db_name": "UniProt", "db_id": "P84328" }, { "db_name": "UniProt", "db_id": "Q00669" }, { "db_name": "UniProt", "db_id": "Q00670" }, { "db_name": "UniProt", "db_id": "Q00671" }, { "db_name": "UniProt", "db_id": "Q00672" }, { "db_name": "UniProt", "db_id": "Q03384" }, { "db_name": "UniProt", "db_id": "Q05114" }, { "db_name": "UniProt", "db_id": "Q07588" }, { "db_name": "UniProt", "db_id": "Q09009" }, { "db_name": "UniProt", "db_id": "Q09010" }, { "db_name": "UniProt", "db_id": "Q24641" }, { "db_name": "UniProt", "db_id": "Q24803" }, { "db_name": "UniProt", "db_id": "Q27404" }, { "db_name": "UniProt", "db_id": "Q6LCE4" }, { "db_name": "UniProt", "db_id": "Q9GN94" }, { "db_name": "UniProt", "db_id": "Q9NAR7" }, { "db_name": "UniProt", "db_id": "Q9NG40" }, { "db_name": "UniProt", "db_id": "Q9NG42" }, { "db_name": "UniProt", "db_id": "Q9U8S9" } ] }, { "id": "DS.d975.s1.e3", "type": "protein", "text": [ "ADH" ], "offsets": [ [ 456, 459 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06525" }, { "db_name": "UniProt", "db_id": "P0A9Q7" }, { "db_name": "UniProt", "db_id": "P0A9Q8" }, { "db_name": "UniProt", "db_id": "P17648" }, { "db_name": "UniProt", "db_id": "P33744" }, { "db_name": "UniProt", "db_id": "P42327" }, { "db_name": "UniProt", "db_id": "P48977" }, { "db_name": "UniProt", "db_id": "P81786" }, { "db_name": "UniProt", "db_id": "Q04983" }, { "db_name": "UniProt", "db_id": "Q24803" }, { "db_name": "UniProt", "db_id": "Q24857" }, { "db_name": "UniProt", "db_id": "Q9NAR7" } ] } ]
[]
[]
[ { "id": "DS.d975.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d975.s0.e4", "arg2_id": "DS.d975.s0.e1", "normalized": [] }, { "id": "DS.d975.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d975.s0.e4", "arg2_id": "DS.d975.s0.e0", "normalized": [] } ]
DS.d976
18760912
[ { "id": "DS.d976.s0", "type": "", "text": [ "We also examined cellular impedance responsiveness of PC 12 cells in response to phenotypic alteration especially with regard to modulation of ion fluxes using nerve growth factor (NGF), dexamethasone and forskolin." ], "offsets": [ [ 0, 215 ] ] } ]
[ { "id": "DS.d976.s0.e0", "type": "protein", "text": [ "NGF" ], "offsets": [ [ 181, 184 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21617" }, { "db_name": "UniProt", "db_id": "P34129" }, { "db_name": "UniProt", "db_id": "Q6YBR5" }, { "db_name": "UniProt", "db_id": "Q90W38" } ] }, { "id": "DS.d976.s0.e1", "type": "compound", "text": [ "dexamethasone" ], "offsets": [ [ 187, 200 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5743" } ] }, { "id": "DS.d976.s0.e2", "type": "compound", "text": [ "forskolin" ], "offsets": [ [ 205, 214 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "47936" } ] } ]
[]
[]
[]
DS.d977
18760952
[ { "id": "DS.d977.s0", "type": "", "text": [ "This paper investigates the effect of sterilisation by gamma irradiation (dose 2.5Mrad) on the following properties of polycaprolactone (PCL): (1) degradation rate (catalysed by lipase), (2) mechanical properties, (3) the ability of cells to attach and subsequently grow on its surface." ], "offsets": [ [ 0, 286 ] ] } ]
[ { "id": "DS.d977.s0.e0", "type": "compound", "text": [ "polycaprolactone" ], "offsets": [ [ 119, 135 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10401" } ] }, { "id": "DS.d977.s0.e1", "type": "protein", "text": [ "lipase" ], "offsets": [ [ 178, 184 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q7M4U7" } ] } ]
[]
[]
[ { "id": "DS.d977.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d977.s0.e0", "arg2_id": "DS.d977.s0.e1", "normalized": [] } ]
DS.d978
18761029
[ { "id": "DS.d978.s0", "type": "", "text": [ "Specifically, animals were exposed to one of five dipsetic stimuli: (1) 24-h water deprivation, (2) replacement of drinking water with 2.5% NaCl, (3) peripheral administration of hypertonic saline, (4) ICV injection of angiotensin II (AngII), or (5) the combination of peripheral hypertonic saline and central AngII." ], "offsets": [ [ 0, 316 ] ] } ]
[ { "id": "DS.d978.s0.e0", "type": "compound", "text": [ "NaCl" ], "offsets": [ [ 140, 144 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5234" } ] }, { "id": "DS.d978.s0.e1", "type": "protein", "text": [ "angiotensin II" ], "offsets": [ [ 219, 233 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01015" }, { "db_name": "UniProt", "db_id": "P01016" }, { "db_name": "UniProt", "db_id": "P01017" }, { "db_name": "UniProt", "db_id": "P01019" }, { "db_name": "UniProt", "db_id": "P11859" }, { "db_name": "UniProt", "db_id": "P20757" }, { "db_name": "UniProt", "db_id": "P67885" }, { "db_name": "UniProt", "db_id": "P67886" }, { "db_name": "UniProt", "db_id": "Q9GLN8" }, { "db_name": "UniProt", "db_id": "Q9GLP6" }, { "db_name": "UniProt", "db_id": "Q9TSZ0" } ] }, { "id": "DS.d978.s0.e2", "type": "protein", "text": [ "AngII" ], "offsets": [ [ 235, 240 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01015" }, { "db_name": "UniProt", "db_id": "P01016" }, { "db_name": "UniProt", "db_id": "P01017" }, { "db_name": "UniProt", "db_id": "P01019" }, { "db_name": "UniProt", "db_id": "P11859" }, { "db_name": "UniProt", "db_id": "P20757" }, { "db_name": "UniProt", "db_id": "P67885" }, { "db_name": "UniProt", "db_id": "P67886" }, { "db_name": "UniProt", "db_id": "Q9GLN8" }, { "db_name": "UniProt", "db_id": "Q9GLP6" }, { "db_name": "UniProt", "db_id": "Q9TSZ0" } ] }, { "id": "DS.d978.s0.e3", "type": "protein", "text": [ "AngII" ], "offsets": [ [ 310, 315 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01015" }, { "db_name": "UniProt", "db_id": "P01016" }, { "db_name": "UniProt", "db_id": "P01017" }, { "db_name": "UniProt", "db_id": "P01019" }, { "db_name": "UniProt", "db_id": "P11859" }, { "db_name": "UniProt", "db_id": "P20757" }, { "db_name": "UniProt", "db_id": "P67885" }, { "db_name": "UniProt", "db_id": "P67886" }, { "db_name": "UniProt", "db_id": "Q9GLN8" }, { "db_name": "UniProt", "db_id": "Q9GLP6" }, { "db_name": "UniProt", "db_id": "Q9TSZ0" } ] } ]
[]
[]
[]
DS.d979
18761103
[ { "id": "DS.d979.s0", "type": "", "text": [ "We therefore propose copper-dependent homodimerization to be an essential step in the regulation of ATOX1-dependent transcription." ], "offsets": [ [ 0, 130 ] ] } ]
[ { "id": "DS.d979.s0.e0", "type": "compound", "text": [ "copper" ], "offsets": [ [ 21, 27 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23978" } ] }, { "id": "DS.d979.s0.e1", "type": "protein", "text": [ "ATOX1" ], "offsets": [ [ 100, 105 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00244" }, { "db_name": "UniProt", "db_id": "Q9TT99" }, { "db_name": "UniProt", "db_id": "Q9XT28" } ] } ]
[]
[]
[ { "id": "DS.d979.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d979.s0.e0", "arg2_id": "DS.d979.s0.e1", "normalized": [] } ]
DS.d980
18761380
[ { "id": "DS.d980.s0", "type": "", "text": [ "In order to investigate the role of spinal opioid peptide in the phenomenon of naloxone-precipitated withdrawal we examined the effect of herpes simplex virus vector-mediated overexpression of proenkephalin in lumbar dorsal root ganglia in rats with neuropathic pain treated with morphine." ], "offsets": [ [ 0, 289 ] ] } ]
[ { "id": "DS.d980.s0.e0", "type": "protein", "text": [ "opioid peptide" ], "offsets": [ [ 43, 57 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P84814" } ] }, { "id": "DS.d980.s0.e1", "type": "compound", "text": [ "naloxone" ], "offsets": [ [ 79, 87 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5284596" }, { "db_name": "PubChem", "db_id": "16395294" } ] } ]
[]
[]
[ { "id": "DS.d980.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d980.s0.e1", "arg2_id": "DS.d980.s0.e0", "normalized": [] } ]
DS.d981
18761426
[ { "id": "DS.d981.s0", "type": "", "text": [ "The lectins were isolated by ammonium sulphate treatment of crude extracts followed by chromatography on chitin." ], "offsets": [ [ 0, 112 ] ] } ]
[ { "id": "DS.d981.s0.e0", "type": "protein", "text": [ "lectins" ], "offsets": [ [ 4, 11 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02871" }, { "db_name": "UniProt", "db_id": "P02873" }, { "db_name": "UniProt", "db_id": "P02874" }, { "db_name": "UniProt", "db_id": "P02875" }, { "db_name": "UniProt", "db_id": "P07386" }, { "db_name": "UniProt", "db_id": "P16108" }, { "db_name": "UniProt", "db_id": "P16349" }, { "db_name": "UniProt", "db_id": "P16351" }, { "db_name": "UniProt", "db_id": "P16352" }, { "db_name": "UniProt", "db_id": "P33888" }, { "db_name": "UniProt", "db_id": "P38662" }, { "db_name": "UniProt", "db_id": "P42088" }, { "db_name": "UniProt", "db_id": "P83410" }, { "db_name": "UniProt", "db_id": "P83511" }, { "db_name": "UniProt", "db_id": "P84987" }, { "db_name": "UniProt", "db_id": "Q41114" } ] }, { "id": "DS.d981.s0.e1", "type": "compound", "text": [ "ammonium sulphate" ], "offsets": [ [ 29, 46 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6097028" } ] } ]
[]
[]
[ { "id": "DS.d981.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d981.s0.e1", "arg2_id": "DS.d981.s0.e0", "normalized": [] } ]
DS.d982
18761603
[ { "id": "DS.d982.s0", "type": "", "text": [ "One hundred and forty-four HCV-2- and HCV-3-infected patients initiated Peg-IFN alpha-2a (180 microg/week) and ribavirin (1000 or 1200 mg/day); those with viral clearance at week 4 were randomized to either Peg-IFN alpha-2a monotherapy (n = 59) or continuing combination therapy (n = 61) until week 12." ], "offsets": [ [ 0, 302 ] ] }, { "id": "DS.d982.s1", "type": "", "text": [ "Thus in HCV-2- and HCV-3-infected patients, withdrawal of ribavirin and continuation of Peg-IFN alpha-2a monotherapy may be appropriate to attain an SVR, providing viraemia is cleared early during therapy and associated with low baseline viral load." ], "offsets": [ [ 303, 552 ] ] } ]
[ { "id": "DS.d982.s0.e0", "type": "protein", "text": [ "IFN alpha" ], "offsets": [ [ 76, 85 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P35849" } ] }, { "id": "DS.d982.s0.e1", "type": "compound", "text": [ "ribavirin" ], "offsets": [ [ 111, 120 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "37542" } ] }, { "id": "DS.d982.s0.e2", "type": "protein", "text": [ "IFN alpha" ], "offsets": [ [ 211, 220 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P35849" } ] }, { "id": "DS.d982.s1.e0", "type": "compound", "text": [ "ribavirin" ], "offsets": [ [ 361, 370 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "37542" } ] }, { "id": "DS.d982.s1.e1", "type": "protein", "text": [ "IFN alpha" ], "offsets": [ [ 395, 404 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P35849" } ] } ]
[]
[]
[]
DS.d983
18761779
[ { "id": "DS.d983.s0", "type": "", "text": [ "The apoE-deficient mouse, which develops atherosclerotic lesions rapidly when fed cholesterol, was used to determine the ability of dried plums to reduce atherosclerosis." ], "offsets": [ [ 0, 170 ] ] }, { "id": "DS.d983.s1", "type": "", "text": [ "Urinary thiobarbituric acid-reactive substances (TBARS) excretion and serum amyloid P-component (SAP) were measured as indicators of oxidative stress and inflammation, respectively." ], "offsets": [ [ 171, 352 ] ] } ]
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[]
[]
[]
DS.d984
18762200
[ { "id": "DS.d984.s0", "type": "", "text": [ "Inhibition in the brain is dominated by the neurotransmitter gamma-aminobutyric acid (GABA); operating through GABA(A) receptors." ], "offsets": [ [ 0, 129 ] ] } ]
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[]
[]
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DS.d985
18762201
[ { "id": "DS.d985.s0", "type": "", "text": [ "Thus, in keeping with the ability of neurosteroids to potentiate GABA currents via a broad variety of GABA(A) receptor isoforms in neurons, the potentiation site is structurally highly conserved on this important neurotransmitter receptor family." ], "offsets": [ [ 0, 246 ] ] } ]
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[]
[]
[ { "id": "DS.d985.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d985.s0.e0", "arg2_id": "DS.d985.s0.e1", "normalized": [] } ]
DS.d986
18762202
[ { "id": "DS.d986.s0", "type": "", "text": [ "The 5-HT2AR response dominated the MAPK signaling pathway when co-expressed with 5-HT1AR, and diminution of the response by the 5-HT2AR antagonist Ketanserin could not be rescued by the 5-HT1AR agonist." ], "offsets": [ [ 0, 202 ] ] } ]
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[]
[]
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DS.d987
18762271
[ { "id": "DS.d987.s0", "type": "", "text": [ "The inhibitors include mitogen-inducible gene-6 (Mig-6)/receptor-associated late transducer (RALT)/Gene 33, fibroblast growth factor receptor substrate 2beta (FRS2beta)/suc1-associated neurotrophic factor target-2 (SNT-2)/FRS3, suppressor of cytokine signaling 3 (SOCS3)/SOCS4/SOCS5, and leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1)." ], "offsets": [ [ 0, 351 ] ] } ]
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[]
[]
[]
DS.d988
18762369
[ { "id": "DS.d988.s0", "type": "", "text": [ "Novel homo- and hetero-nuclear copper (II) complexes of tetradentate Schiff bases: synthesis, characterization, solvent-extraction and catalase-like activity studies." ], "offsets": [ [ 0, 166 ] ] } ]
[ { "id": "DS.d988.s0.e0", "type": "compound", "text": [ "copper" ], "offsets": [ [ 31, 37 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23978" } ] }, { "id": "DS.d988.s0.e1", "type": "protein", "text": [ "catalase" ], "offsets": [ [ 135, 143 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24339" }, { "db_name": "UniProt", "db_id": "O52762" }, { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O68146" }, { "db_name": "UniProt", "db_id": "O77229" }, { "db_name": "UniProt", "db_id": "O93662" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P04762" }, { "db_name": "UniProt", "db_id": "P07145" }, { "db_name": "UniProt", "db_id": "P0A323" }, { "db_name": "UniProt", "db_id": "P0A324" }, { "db_name": "UniProt", "db_id": "P0A325" }, { "db_name": "UniProt", "db_id": "P0A326" }, { "db_name": "UniProt", "db_id": "P0A327" }, { "db_name": "UniProt", "db_id": "P11934" }, { "db_name": "UniProt", "db_id": "P17336" }, { "db_name": "UniProt", "db_id": "P24168" }, { "db_name": "UniProt", "db_id": "P24270" }, { "db_name": "UniProt", "db_id": "P25890" }, { "db_name": "UniProt", "db_id": "P29422" }, { "db_name": "UniProt", "db_id": "P30265" }, { "db_name": "UniProt", "db_id": "P30266" }, { "db_name": "UniProt", "db_id": "P32290" }, { "db_name": "UniProt", "db_id": "P42321" }, { "db_name": "UniProt", "db_id": "P44390" }, { "db_name": "UniProt", "db_id": "P45737" }, { "db_name": "UniProt", "db_id": "P45739" }, { "db_name": "UniProt", "db_id": "P55304" }, { "db_name": "UniProt", "db_id": "P55306" }, { "db_name": "UniProt", "db_id": "P55310" }, { "db_name": "UniProt", "db_id": "P55311" }, { "db_name": "UniProt", "db_id": "P55313" }, { "db_name": "UniProt", "db_id": "P77872" }, { "db_name": "UniProt", "db_id": "P81138" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q27710" }, { "db_name": "UniProt", "db_id": "Q49XC1" }, { "db_name": "UniProt", "db_id": "Q4L643" }, { "db_name": "UniProt", "db_id": "Q59296" }, { "db_name": "UniProt", "db_id": "Q59337" }, { "db_name": "UniProt", "db_id": "Q59602" }, { "db_name": "UniProt", "db_id": "Q59714" }, { "db_name": "UniProt", "db_id": "Q5HG86" }, { "db_name": "UniProt", "db_id": "Q5HPK8" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q6G9M4" }, { "db_name": "UniProt", "db_id": "Q6GH72" }, { "db_name": "UniProt", "db_id": "Q7A5T2" }, { "db_name": "UniProt", "db_id": "Q8CPD0" }, { "db_name": "UniProt", "db_id": "Q8FWU0" }, { "db_name": "UniProt", "db_id": "Q8NWV5" }, { "db_name": "UniProt", "db_id": "Q8X1P0" }, { "db_name": "UniProt", "db_id": "Q8Y3P9" }, { "db_name": "UniProt", "db_id": "Q926X0" }, { "db_name": "UniProt", "db_id": "Q99UE2" }, { "db_name": "UniProt", "db_id": "Q9AXH0" }, { "db_name": "UniProt", "db_id": "Q9KW19" }, { "db_name": "UniProt", "db_id": "Q9L4S1" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PT92" }, { "db_name": "UniProt", "db_id": "Q9PWF7" }, { "db_name": "UniProt", "db_id": "Q9Z598" }, { "db_name": "UniProt", "db_id": "Q9ZKX5" }, { "db_name": "UniProt", "db_id": "Q9ZN99" } ] } ]
[]
[]
[ { "id": "DS.d988.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d988.s0.e0", "arg2_id": "DS.d988.s0.e1", "normalized": [] } ]
DS.d989
18762913
[ { "id": "DS.d989.s0", "type": "", "text": [ "In streptozotocin-nicotinamide-induced diabetic mice, ASP8497 was administered orally for 3 weeks at 1, 3, or 10 mg/kg once daily, which improved the hemoglobin A (1c), non-fasting plasma insulin, fasting blood glucose levels, glucose intolerance, and lipid profiles (plasma triglyceride, non-esterified fatty acid and total cholesterol) with neutral effect on body weight." ], "offsets": [ [ 0, 373 ] ] } ]
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[]
[]
[]
DS.d990
18762977
[ { "id": "DS.d990.s0", "type": "", "text": [ "The laboratory findings of the cases were compatible with VDDR; serum calcium (Ca) 7.5+/-1.9 mg/dL, PO4 4.4+/-1.3 mg/dL, alkaline phosphatase (ALP) 1,341+/-823, 25-hydroxyvitamin D (25 (OH) D) 5.8+/-2.9 ng/mL, intact parathyroid hormone (iPTH) 240+/-106 pg/mL." ], "offsets": [ [ 0, 260 ] ] } ]
[ { "id": "DS.d990.s0.e0", "type": "compound", "text": [ "PO4" ], "offsets": [ [ 100, 103 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1061" } ] }, { "id": "DS.d990.s0.e1", "type": "protein", "text": [ "alkaline phosphatase" ], "offsets": [ [ 121, 141 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60109" }, { "db_name": "UniProt", "db_id": "P81800" }, { "db_name": "UniProt", "db_id": "P83456" } ] }, { "id": "DS.d990.s0.e2", "type": "protein", "text": [ "ALP" ], "offsets": [ [ 143, 146 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03973" }, { "db_name": "UniProt", "db_id": "P12547" }, { "db_name": "UniProt", "db_id": "P22298" }, { "db_name": "UniProt", "db_id": "P28296" }, { "db_name": "UniProt", "db_id": "P29118" }, { "db_name": "UniProt", "db_id": "P35211" }, { "db_name": "UniProt", "db_id": "P83610" }, { "db_name": "UniProt", "db_id": "P97430" }, { "db_name": "UniProt", "db_id": "Q03420" }, { "db_name": "UniProt", "db_id": "Q53GG5" }, { "db_name": "UniProt", "db_id": "Q9H0A0" }, { "db_name": "UniProt", "db_id": "Q9PU47" }, { "db_name": "UniProt", "db_id": "Q9Z1X0" } ] }, { "id": "DS.d990.s0.e3", "type": "compound", "text": [ "25-hydroxyvitamin D" ], "offsets": [ [ 161, 180 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5283731" }, { "db_name": "PubChem", "db_id": "6433735" } ] } ]
[]
[]
[]
DS.d991
18763027
[ { "id": "DS.d991.s0", "type": "", "text": [ "There are no controlled trials comparing etanercept and acitretin efficacy and therapeutic mechanisms in psoriasis." ], "offsets": [ [ 0, 115 ] ] } ]
[ { "id": "DS.d991.s0.e0", "type": "protein", "text": [ "etanercept" ], "offsets": [ [ 41, 51 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20333" } ] }, { "id": "DS.d991.s0.e1", "type": "compound", "text": [ "acitretin" ], "offsets": [ [ 56, 65 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5284513" } ] } ]
[]
[]
[]
DS.d992
18763047
[ { "id": "DS.d992.s0", "type": "", "text": [ "Oral immunogenicity and protective efficacy in mice of transgenic rice plants producing a vaccine candidate antigen (As16) of Ascaris suum fused with cholera toxin B subunit." ], "offsets": [ [ 0, 174 ] ] } ]
[ { "id": "DS.d992.s0.e0", "type": "compound", "text": [ "As16" ], "offsets": [ [ 117, 121 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10196533" } ] }, { "id": "DS.d992.s0.e1", "type": "protein", "text": [ "toxin B" ], "offsets": [ [ 158, 165 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01380" }, { "db_name": "UniProt", "db_id": "P18177" }, { "db_name": "UniProt", "db_id": "P25669" } ] } ]
[]
[]
[]
DS.d993
18763168
[ { "id": "DS.d993.s0", "type": "", "text": [ "Inhibition of human poly(A)-specific ribonuclease (PARN) by purine nucleotides: kinetic analysis." ], "offsets": [ [ 0, 97 ] ] } ]
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[]
[]
[ { "id": "DS.d993.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d993.s0.e2", "arg2_id": "DS.d993.s0.e0", "normalized": [] }, { "id": "DS.d993.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d993.s0.e2", "arg2_id": "DS.d993.s0.e1", "normalized": [] } ]
DS.d994
18764779
[ { "id": "DS.d994.s0", "type": "", "text": [ "The aqueous extract was found to be more effective than doxorubicin, a classical anticarcinogenic drug, with respect to its action on antioxidant enzymes and LDH in the liver of mice with developing lymphomas." ], "offsets": [ [ 0, 209 ] ] } ]
[ { "id": "DS.d994.s0.e0", "type": "compound", "text": [ "doxorubicin" ], "offsets": [ [ 56, 67 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "31703" } ] }, { "id": "DS.d994.s0.e1", "type": "protein", "text": [ "LDH" ], "offsets": [ [ 158, 161 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29038" }, { "db_name": "UniProt", "db_id": "P33571" }, { "db_name": "UniProt", "db_id": "P93052" }, { "db_name": "UniProt", "db_id": "Q27797" }, { "db_name": "UniProt", "db_id": "Q27888" }, { "db_name": "UniProt", "db_id": "Q95028" }, { "db_name": "UniProt", "db_id": "Q99289" } ] } ]
[]
[]
[ { "id": "DS.d994.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d994.s0.e0", "arg2_id": "DS.d994.s0.e1", "normalized": [] } ]
DS.d995
18764780
[ { "id": "DS.d995.s0", "type": "", "text": [ "Cu,Zn-superoxide dismutase-driven free radical modifications: copper- and carbonate radical anion-initiated protein radical chemistry." ], "offsets": [ [ 0, 134 ] ] }, { "id": "DS.d995.s1", "type": "", "text": [ "The understanding of the mechanism, oxidant(s) involved and how and what protein radicals are produced during the reaction of wild-type SOD1 (Cu,Zn-superoxide dismutase) with H2O2 and their fate is incomplete, but a better understanding of the role of this reaction is needed." ], "offsets": [ [ 135, 411 ] ] }, { "id": "DS.d995.s2", "type": "", "text": [ "In the absence of (bi)carbonate, site-specific radical-mediated fragmentation is produced by SOD1 active-site copper." ], "offsets": [ [ 412, 529 ] ] }, { "id": "DS.d995.s3", "type": "", "text": [ "Finally, we propose a biochemical mechanism to explain CO(*-) production from CO2, enhanced protein radical formation and protection by (bi)carbonate against H2O2-induced fragmentation of the SOD1 active site." ], "offsets": [ [ 530, 739 ] ] } ]
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"UniProt", "db_id": "P60052" }, { "db_name": "UniProt", "db_id": "P80566" }, { "db_name": "UniProt", "db_id": "P93258" }, { "db_name": "UniProt", "db_id": "Q42684" }, { "db_name": "UniProt", "db_id": "Q52RN5" }, { "db_name": "UniProt", "db_id": "Q5FB29" }, { "db_name": "UniProt", "db_id": "Q6C662" }, { "db_name": "UniProt", "db_id": "Q6CPE2" }, { "db_name": "UniProt", "db_id": "Q6FWL5" }, { "db_name": "UniProt", "db_id": "Q6T3B0" }, { "db_name": "UniProt", "db_id": "Q711T9" }, { "db_name": "UniProt", "db_id": "Q751L8" }, { "db_name": "UniProt", "db_id": "Q7M1R5" }, { "db_name": "UniProt", "db_id": "Q8HXP8" }, { "db_name": "UniProt", "db_id": "Q8HXP9" }, { "db_name": "UniProt", "db_id": "Q8HXQ0" }, { "db_name": "UniProt", "db_id": "Q8HXQ1" }, { "db_name": "UniProt", "db_id": "Q8HXQ2" }, { "db_name": "UniProt", "db_id": "Q8HXQ3" }, { "db_name": "UniProt", "db_id": "Q8HXQ4" }, { "db_name": "UniProt", "db_id": "Q8J0N2" }, { "db_name": "UniProt", "db_id": "Q8J0N3" }, { "db_name": "UniProt", "db_id": "Q8WNN6" }, { "db_name": "UniProt", "db_id": "Q96VL0" }, { "db_name": "UniProt", "db_id": "Q9C0N4" }, { "db_name": "UniProt", "db_id": "Q9SQL5" } ] }, { "id": "DS.d995.s1.e1", "type": "protein", "text": [ "superoxide dismutase" ], "offsets": [ [ 283, 303 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50258" } ] }, { "id": "DS.d995.s1.e2", "type": "compound", "text": [ "H2O2" ], "offsets": [ [ 310, 314 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "784" } ] }, { "id": "DS.d995.s2.e0", "type": "protein", "text": [ "SOD1" ], "offsets": [ [ 505, 509 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42724" }, { "db_name": "UniProt", "db_id": "O46412" }, { "db_name": "UniProt", "db_id": "O59924" }, { "db_name": "UniProt", "db_id": "O94178" }, { "db_name": "UniProt", "db_id": "P00441" }, { "db_name": "UniProt", "db_id": "P00442" }, { "db_name": "UniProt", "db_id": "P00443" }, { "db_name": "UniProt", "db_id": "P00445" }, { "db_name": "UniProt", "db_id": "P04178" }, { "db_name": "UniProt", "db_id": "P09212" }, { "db_name": "UniProt", "db_id": "P09670" }, { "db_name": "UniProt", "db_id": "P33431" }, { "db_name": "UniProt", "db_id": "P60052" }, { "db_name": "UniProt", "db_id": "P80566" }, { "db_name": "UniProt", "db_id": "P93258" }, { "db_name": "UniProt", "db_id": "Q42684" }, { "db_name": "UniProt", "db_id": "Q52RN5" }, { "db_name": "UniProt", "db_id": "Q5FB29" }, { "db_name": "UniProt", "db_id": "Q6C662" }, { "db_name": "UniProt", "db_id": "Q6CPE2" }, { "db_name": "UniProt", "db_id": "Q6FWL5" }, { "db_name": "UniProt", "db_id": "Q6T3B0" }, { "db_name": "UniProt", "db_id": "Q711T9" }, { "db_name": "UniProt", "db_id": "Q751L8" }, { "db_name": "UniProt", "db_id": "Q7M1R5" }, { "db_name": "UniProt", "db_id": "Q8HXP8" }, { "db_name": "UniProt", "db_id": "Q8HXP9" }, { "db_name": "UniProt", "db_id": "Q8HXQ0" }, { "db_name": "UniProt", "db_id": "Q8HXQ1" }, { "db_name": "UniProt", "db_id": "Q8HXQ2" }, { "db_name": "UniProt", "db_id": "Q8HXQ3" }, { "db_name": "UniProt", "db_id": "Q8HXQ4" }, { "db_name": "UniProt", "db_id": "Q8J0N2" }, { "db_name": "UniProt", "db_id": "Q8J0N3" }, { "db_name": "UniProt", "db_id": "Q8WNN6" }, { "db_name": "UniProt", "db_id": "Q96VL0" }, { "db_name": "UniProt", "db_id": "Q9C0N4" }, { "db_name": "UniProt", "db_id": "Q9SQL5" } ] }, { "id": "DS.d995.s2.e1", "type": "compound", "text": [ "copper" ], "offsets": [ [ 522, 528 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23978" } ] }, { "id": "DS.d995.s3.e0", "type": "compound", "text": [ "H2O2" ], "offsets": [ [ 688, 692 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "784" } ] }, { "id": "DS.d995.s3.e1", "type": "protein", "text": [ "SOD1" ], "offsets": [ [ 722, 726 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42724" }, { "db_name": "UniProt", "db_id": "O46412" }, { "db_name": "UniProt", "db_id": "O59924" }, { "db_name": "UniProt", "db_id": "O94178" }, { "db_name": "UniProt", "db_id": "P00441" }, { "db_name": "UniProt", "db_id": "P00442" }, { "db_name": "UniProt", "db_id": "P00443" }, { "db_name": "UniProt", "db_id": "P00445" }, { "db_name": "UniProt", "db_id": "P04178" }, { "db_name": "UniProt", "db_id": "P09212" }, { "db_name": "UniProt", "db_id": "P09670" }, { "db_name": "UniProt", "db_id": "P33431" }, { "db_name": "UniProt", "db_id": "P60052" }, { "db_name": "UniProt", "db_id": "P80566" }, { "db_name": "UniProt", "db_id": "P93258" }, { "db_name": "UniProt", "db_id": "Q42684" }, { "db_name": "UniProt", "db_id": "Q52RN5" }, { "db_name": "UniProt", "db_id": "Q5FB29" }, { "db_name": "UniProt", "db_id": "Q6C662" }, { "db_name": "UniProt", "db_id": "Q6CPE2" }, { "db_name": "UniProt", "db_id": "Q6FWL5" }, { "db_name": "UniProt", "db_id": "Q6T3B0" }, { "db_name": "UniProt", "db_id": "Q711T9" }, { "db_name": "UniProt", "db_id": "Q751L8" }, { "db_name": "UniProt", "db_id": "Q7M1R5" }, { "db_name": "UniProt", "db_id": "Q8HXP8" }, { "db_name": "UniProt", "db_id": "Q8HXP9" }, { "db_name": "UniProt", "db_id": "Q8HXQ0" }, { "db_name": "UniProt", "db_id": "Q8HXQ1" }, { "db_name": "UniProt", "db_id": "Q8HXQ2" }, { "db_name": "UniProt", "db_id": "Q8HXQ3" }, { "db_name": "UniProt", "db_id": "Q8HXQ4" }, { "db_name": "UniProt", "db_id": "Q8J0N2" }, { "db_name": "UniProt", "db_id": "Q8J0N3" }, { "db_name": "UniProt", "db_id": "Q8WNN6" }, { "db_name": "UniProt", "db_id": "Q96VL0" }, { "db_name": "UniProt", "db_id": "Q9C0N4" }, { "db_name": "UniProt", "db_id": "Q9SQL5" } ] } ]
[]
[]
[ { "id": "DS.d995.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d995.s1.e2", "arg2_id": "DS.d995.s1.e0", "normalized": [] }, { "id": "DS.d995.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d995.s1.e2", "arg2_id": "DS.d995.s1.e1", "normalized": [] }, { "id": "DS.d995.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d995.s2.e1", "arg2_id": "DS.d995.s2.e0", "normalized": [] }, { "id": "DS.d995.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d995.s3.e0", "arg2_id": "DS.d995.s3.e1", "normalized": [] } ]
DS.d996
18764784
[ { "id": "DS.d996.s0", "type": "", "text": [ "Furthermore, lysosomal integrity was disrupted after addition of clioquinol and zinc to the cells, as shown by redistribution of both Acridine Orange and cathepsin D. Clioquinol plus zinc resulted in a cleavage of Bid (BH3-interacting domain death agonist), a hallmark of lysosome-mediated apoptotic cell death." ], "offsets": [ [ 0, 311 ] ] } ]
[ { "id": "DS.d996.s0.e0", "type": "compound", "text": [ "clioquinol" ], "offsets": [ [ 65, 75 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2788" } ] }, { "id": "DS.d996.s0.e1", "type": "compound", "text": [ "Acridine Orange" ], "offsets": [ [ 134, 149 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "62344" } ] }, { "id": "DS.d996.s0.e2", "type": "compound", "text": [ "Clioquinol" ], "offsets": [ [ 167, 177 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2788" } ] }, { "id": "DS.d996.s0.e3", "type": "protein", "text": [ "BH3-interacting domain death agonist" ], "offsets": [ [ 219, 255 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P55957" }, { "db_name": "UniProt", "db_id": "P70444" }, { "db_name": "UniProt", "db_id": "Q4JHS0" }, { "db_name": "UniProt", "db_id": "Q8JGM8" }, { "db_name": "UniProt", "db_id": "Q9JLT6" } ] } ]
[]
[]
[ { "id": "DS.d996.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d996.s0.e2", "arg2_id": "DS.d996.s0.e3", "normalized": [] }, { "id": "DS.d996.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d996.s0.e0", "arg2_id": "DS.d996.s0.e3", "normalized": [] } ]
DS.d997
18764864
[ { "id": "DS.d997.s0", "type": "", "text": [ "Imidazoline-induced amplification of glucose- and carbachol-stimulated insulin release includes a marked suppression of islet nitric oxide generation in the mouse." ], "offsets": [ [ 0, 163 ] ] } ]
[ { "id": "DS.d997.s0.e0", "type": "compound", "text": [ "Imidazoline" ], "offsets": [ [ 0, 11 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "68156" } ] }, { "id": "DS.d997.s0.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 37, 44 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d997.s0.e2", "type": "compound", "text": [ "carbachol" ], "offsets": [ [ 50, 59 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2551" } ] }, { "id": "DS.d997.s0.e3", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 71, 78 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]
[]
[]
[ { "id": "DS.d997.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d997.s0.e2", "arg2_id": "DS.d997.s0.e3", "normalized": [] }, { "id": "DS.d997.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d997.s0.e1", "arg2_id": "DS.d997.s0.e3", "normalized": [] }, { "id": "DS.d997.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d997.s0.e0", "arg2_id": "DS.d997.s0.e3", "normalized": [] } ]
DS.d998
18764923
[ { "id": "DS.d998.s0", "type": "", "text": [ "The picture of signalling mechanisms underlying the wound-regulated FAD7 expression, and potential roles of CPL proteins as attenuators of wound-induced JA biosynthesis, are discussed." ], "offsets": [ [ 0, 184 ] ] } ]
[ { "id": "DS.d998.s0.e0", "type": "protein", "text": [ "FAD7" ], "offsets": [ [ 68, 72 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P46310" }, { "db_name": "UniProt", "db_id": "P48618" }, { "db_name": "UniProt", "db_id": "P48620" }, { "db_name": "UniProt", "db_id": "P48621" } ] }, { "id": "DS.d998.s0.e1", "type": "protein", "text": [ "CPL" ], "offsets": [ [ 108, 111 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P26602" }, { "db_name": "UniProt", "db_id": "P81711" }, { "db_name": "UniProt", "db_id": "Q0TA23" }, { "db_name": "UniProt", "db_id": "Q0VTA8" }, { "db_name": "UniProt", "db_id": "Q142T1" }, { "db_name": "UniProt", "db_id": "Q1BUR8" }, { "db_name": "UniProt", "db_id": "Q1C0T7" }, { "db_name": "UniProt", "db_id": "Q1CE94" }, { "db_name": "UniProt", "db_id": "Q1GXB4" }, { "db_name": "UniProt", "db_id": "Q1LIU6" }, { "db_name": "UniProt", "db_id": "Q1QE02" }, { "db_name": "UniProt", "db_id": "Q1QSG3" }, { "db_name": "UniProt", "db_id": "Q1R3P7" }, { "db_name": "UniProt", "db_id": "Q21U27" }, { "db_name": "UniProt", "db_id": "Q2L1H6" }, { "db_name": "UniProt", "db_id": "Q2NR06" }, { "db_name": "UniProt", "db_id": "Q2SZY9" }, { "db_name": "UniProt", "db_id": "Q2Y5S2" }, { "db_name": "UniProt", "db_id": "Q31DN1" }, { "db_name": "UniProt", "db_id": "Q31TU7" }, { "db_name": "UniProt", "db_id": "Q327U6" }, { "db_name": "UniProt", "db_id": "Q39E37" }, { "db_name": "UniProt", "db_id": "Q3IHW4" }, { "db_name": "UniProt", "db_id": "Q3SLJ3" }, { "db_name": "UniProt", "db_id": "Q3YUU5" }, { "db_name": "UniProt", "db_id": "Q46XB3" }, { "db_name": "UniProt", "db_id": "Q47AZ9" }, { "db_name": "UniProt", "db_id": "Q48AM0" }, { "db_name": "UniProt", "db_id": "Q48BQ6" }, { "db_name": "UniProt", "db_id": "Q4FUZ9" }, { "db_name": "UniProt", "db_id": "Q4K3M0" }, { "db_name": "UniProt", "db_id": "Q4ZLB5" }, { "db_name": "UniProt", "db_id": "Q57GZ4" }, { "db_name": "UniProt", "db_id": "Q5E206" }, { "db_name": "UniProt", "db_id": "Q5P5L9" }, { "db_name": "UniProt", "db_id": "Q5PL18" }, { "db_name": "UniProt", "db_id": "Q5QUP2" }, { "db_name": "UniProt", "db_id": "Q609A0" }, { "db_name": "UniProt", "db_id": "Q62ID2" }, { "db_name": "UniProt", "db_id": "Q63W06" }, { "db_name": "UniProt", "db_id": "Q66FH1" }, { "db_name": "UniProt", "db_id": "Q6D9I9" }, { "db_name": "UniProt", "db_id": "Q6F9N7" }, { "db_name": "UniProt", "db_id": "Q6FZ67" }, { "db_name": "UniProt", "db_id": "Q6G5M1" }, { "db_name": "UniProt", "db_id": "Q6LVS4" }, { "db_name": "UniProt", "db_id": "Q70C33" }, { "db_name": "UniProt", "db_id": "Q7MQ88" }, { "db_name": "UniProt", "db_id": "Q7MZB5" }, { "db_name": "UniProt", "db_id": "Q7VZD6" }, { "db_name": "UniProt", "db_id": "Q7WAC9" }, { "db_name": "UniProt", "db_id": "Q7WJH0" }, { "db_name": "UniProt", "db_id": "Q82TP3" }, { "db_name": "UniProt", "db_id": "Q83F94" }, { "db_name": "UniProt", "db_id": "Q83IP6" }, { "db_name": "UniProt", "db_id": "Q87KM8" }, { "db_name": "UniProt", "db_id": "Q87U40" }, { "db_name": "UniProt", "db_id": "Q88C66" }, { "db_name": "UniProt", "db_id": "Q8DD50" }, { "db_name": "UniProt", "db_id": "Q8EKG2" }, { "db_name": "UniProt", "db_id": "Q8FB35" }, { "db_name": "UniProt", "db_id": "Q8XEC3" }, { "db_name": "UniProt", "db_id": "Q8XVQ0" }, { "db_name": "UniProt", "db_id": "Q8Z1T7" }, { "db_name": "UniProt", "db_id": "Q8ZJ20" }, { "db_name": "UniProt", "db_id": "Q8ZKI0" }, { "db_name": "UniProt", "db_id": "Q9CMB5" }, { "db_name": "UniProt", "db_id": "Q9FD32" }, { "db_name": "UniProt", "db_id": "Q9HTK1" }, { "db_name": "UniProt", "db_id": "Q9KVP6" } ] }, { "id": "DS.d998.s0.e2", "type": "compound", "text": [ "JA" ], "offsets": [ [ 153, 155 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5281166" } ] } ]
[]
[]
[]
DS.d999
18765263
[ { "id": "DS.d999.s0", "type": "", "text": [ "KiSS-1 mRNA was significantly increased by seizure activity in rats and when neuronal activity in organotypic hippocampal slice cultures was enhanced by kainate or picrotoxin, while mRNA for GPR54 remained essentially unchanged." ], "offsets": [ [ 0, 228 ] ] } ]
[ { "id": "DS.d999.s0.e0", "type": "compound", "text": [ "kainate" ], "offsets": [ [ 153, 160 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10255" } ] }, { "id": "DS.d999.s0.e1", "type": "compound", "text": [ "picrotoxin" ], "offsets": [ [ 164, 174 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "31304" }, { "db_name": "PubChem", "db_id": "518601" }, { "db_name": "PubChem", "db_id": "5311359" }, { "db_name": "PubChem", "db_id": "5458938" }, { "db_name": "PubChem", "db_id": "6473767" }, { "db_name": "PubChem", "db_id": "24867522" }, { "db_name": "PubChem", "db_id": "57402144" } ] }, { "id": "DS.d999.s0.e2", "type": "protein", "text": [ "GPR54" ], "offsets": [ [ 191, 196 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q6BD04" }, { "db_name": "UniProt", "db_id": "Q969F8" } ] } ]
[]
[]
[]
DS.d1000
18765295
[ { "id": "DS.d1000.s0", "type": "", "text": [ "In permeabilized muscle fibers, we observed, a strong inhibition of both state 3 mitochondrial respiration and functionally isolated maximal cytochrome c oxidase (COX) activity after 49 days of MeHg exposure." ], "offsets": [ [ 0, 208 ] ] } ]
[ { "id": "DS.d1000.s0.e0", "type": "protein", "text": [ "cytochrome c" ], "offsets": [ [ 141, 153 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O07091" }, { "db_name": "UniProt", "db_id": "O13393" }, { "db_name": "UniProt", "db_id": "O22642" }, { "db_name": "UniProt", "db_id": "O93863" }, { "db_name": "UniProt", "db_id": "P00002" }, { "db_name": "UniProt", "db_id": "P00003" }, { "db_name": "UniProt", "db_id": "P00004" }, { "db_name": "UniProt", "db_id": "P00007" }, { "db_name": "UniProt", "db_id": "P00008" }, { "db_name": "UniProt", "db_id": "P00011" }, { "db_name": "UniProt", "db_id": "P00012" }, { "db_name": "UniProt", "db_id": "P00013" }, { "db_name": "UniProt", "db_id": "P00014" }, { "db_name": "UniProt", "db_id": "P00017" }, { "db_name": "UniProt", "db_id": "P00018" }, { "db_name": "UniProt", "db_id": "P00019" }, { "db_name": "UniProt", "db_id": "P00020" }, { "db_name": "UniProt", "db_id": "P00021" }, { "db_name": "UniProt", "db_id": "P00022" }, { "db_name": "UniProt", "db_id": "P00024" }, { "db_name": "UniProt", "db_id": "P00025" }, { "db_name": "UniProt", "db_id": "P00027" }, { "db_name": "UniProt", "db_id": "P00028" }, { "db_name": "UniProt", "db_id": "P00029" }, { "db_name": "UniProt", "db_id": "P00030" }, { "db_name": "UniProt", "db_id": "P00031" }, { "db_name": "UniProt", "db_id": "P00032" }, { "db_name": "UniProt", "db_id": "P00035" }, { "db_name": "UniProt", "db_id": "P00036" }, { "db_name": "UniProt", "db_id": "P00037" }, { "db_name": "UniProt", "db_id": "P00038" }, { "db_name": "UniProt", "db_id": "P00039" }, { "db_name": "UniProt", "db_id": "P00040" }, { "db_name": "UniProt", "db_id": "P00041" }, { "db_name": "UniProt", "db_id": "P00042" }, { "db_name": "UniProt", "db_id": "P00043" }, { "db_name": "UniProt", "db_id": "P00046" }, { "db_name": "UniProt", "db_id": "P00047" }, { "db_name": "UniProt", "db_id": "P00048" }, { "db_name": "UniProt", "db_id": "P00049" }, { "db_name": "UniProt", "db_id": "P00051" }, { "db_name": "UniProt", "db_id": 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}, { "db_name": "UniProt", "db_id": "P00075" }, { "db_name": "UniProt", "db_id": "P00076" }, { "db_name": "UniProt", "db_id": "P00077" }, { "db_name": "UniProt", "db_id": "P00078" }, { "db_name": "UniProt", "db_id": "P00079" }, { "db_name": "UniProt", "db_id": "P12831" }, { "db_name": "UniProt", "db_id": "P15451" }, { "db_name": "UniProt", "db_id": "P18822" }, { "db_name": "UniProt", "db_id": "P19681" }, { "db_name": "UniProt", "db_id": "P19974" }, { "db_name": "UniProt", "db_id": "P21665" }, { "db_name": "UniProt", "db_id": "P22342" }, { "db_name": "UniProt", "db_id": "P25400" }, { "db_name": "UniProt", "db_id": "P29380" }, { "db_name": "UniProt", "db_id": "P32556" }, { "db_name": "UniProt", "db_id": "P38091" }, { "db_name": "UniProt", "db_id": "P53698" }, { "db_name": "UniProt", "db_id": "P56205" }, { "db_name": "UniProt", "db_id": "P59218" }, { "db_name": "UniProt", "db_id": "P62772" }, { "db_name": "UniProt", "db_id": "P62773" }, { "db_name": "UniProt", "db_id": "P62894" }, { "db_name": "UniProt", "db_id": "P62895" }, { "db_name": "UniProt", "db_id": "P62896" }, { "db_name": "UniProt", "db_id": "P67881" }, { "db_name": "UniProt", "db_id": "P67882" }, { "db_name": "UniProt", "db_id": "P68096" }, { "db_name": "UniProt", "db_id": "P68097" }, { "db_name": "UniProt", "db_id": "P68098" }, { "db_name": "UniProt", "db_id": "P68099" }, { "db_name": "UniProt", "db_id": "P68100" }, { "db_name": "UniProt", "db_id": "P68517" }, { "db_name": "UniProt", "db_id": "P68518" }, { "db_name": "UniProt", "db_id": "P68519" }, { "db_name": "UniProt", "db_id": "P81280" }, { "db_name": "UniProt", "db_id": "P81459" }, { "db_name": "UniProt", "db_id": "P99998" }, { "db_name": "UniProt", "db_id": "P99999" }, { "db_name": "UniProt", "db_id": "Q41346" }, { "db_name": "UniProt", "db_id": "Q4HVX7" }, { "db_name": "UniProt", "db_id": "Q52V08" }, { "db_name": "UniProt", "db_id": "Q52V09" }, { "db_name": "UniProt", "db_id": "Q52V10" }, { "db_name": "UniProt", "db_id": "Q5RFH4" }, { "db_name": "UniProt", "db_id": "Q640U4" }, { "db_name": "UniProt", "db_id": "Q6C9Q0" }, { "db_name": "UniProt", "db_id": "Q6IQM2" }, { "db_name": "UniProt", "db_id": "Q6Q4H8" }, { "db_name": "UniProt", "db_id": "Q6QLW4" }, { "db_name": "UniProt", "db_id": "Q6WUX8" }, { "db_name": "UniProt", "db_id": "Q753F4" }, { "db_name": "UniProt", "db_id": "Q7YR71" }, { "db_name": "UniProt", "db_id": "Q96VP3" } ] }, { "id": "DS.d1000.s0.e1", "type": "protein", "text": [ "COX" ], "offsets": [ [ 163, 166 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11353" }, { "db_name": "UniProt", "db_id": "P36551" }, { "db_name": "UniProt", "db_id": "P36552" }, { "db_name": "UniProt", "db_id": "Q9UTE2" }, { "db_name": "UniProt", "db_id": "Q9V3D2" } ] }, { "id": "DS.d1000.s0.e2", "type": "compound", "text": [ "MeHg" ], "offsets": [ [ 194, 198 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6860" } ] } ]
[]
[]
[ { "id": "DS.d1000.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1000.s0.e2", "arg2_id": "DS.d1000.s0.e1", "normalized": [] }, { "id": "DS.d1000.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1000.s0.e2", "arg2_id": "DS.d1000.s0.e0", "normalized": [] } ]
DS.d1001
18765678
[ { "id": "DS.d1001.s0", "type": "", "text": [ "The dominant positive regulator of mTORC1 is the GTP-charged form of the ras-like GTPase Rheb." ], "offsets": [ [ 0, 94 ] ] }, { "id": "DS.d1001.s1", "type": "", "text": [ "In contrast, amino acids, especially leucine, regulate mTORC1 by controlling the ability of Rheb-GTP to activate mTORC1." ], "offsets": [ [ 95, 215 ] ] } ]
[ { "id": "DS.d1001.s0.e0", "type": "compound", "text": [ "GTP" ], "offsets": [ [ 49, 52 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6830" } ] }, { "id": "DS.d1001.s0.e1", "type": "protein", "text": [ "ras" ], "offsets": [ [ 73, 76 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03967" }, { "db_name": "UniProt", "db_id": "P22126" }, { "db_name": "UniProt", "db_id": "Q07152" } ] }, { "id": "DS.d1001.s0.e2", "type": "protein", "text": [ "Rheb" ], "offsets": [ [ 89, 93 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q62639" }, { "db_name": "UniProt", "db_id": "Q921J2" }, { "db_name": "UniProt", "db_id": "Q9VND8" } ] }, { "id": "DS.d1001.s1.e0", "type": "protein", "text": [ "Rheb" ], "offsets": [ [ 187, 191 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q62639" }, { "db_name": "UniProt", "db_id": "Q921J2" }, { "db_name": "UniProt", "db_id": "Q9VND8" } ] }, { "id": "DS.d1001.s1.e1", "type": "compound", "text": [ "GTP" ], "offsets": [ [ 192, 195 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6830" } ] } ]
[]
[]
[ { "id": "DS.d1001.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1001.s0.e0", "arg2_id": "DS.d1001.s0.e1", "normalized": [] }, { "id": "DS.d1001.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1001.s0.e0", "arg2_id": "DS.d1001.s0.e2", "normalized": [] }, { "id": "DS.d1001.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1001.s1.e1", "arg2_id": "DS.d1001.s1.e0", "normalized": [] } ]
DS.d1002
18765850
[ { "id": "DS.d1002.s0", "type": "", "text": [ "Cortisol, hematocrit, blood urea nitrogen, total protein, albumin, aspartate aminotransferase 0.05) after transport regardless of space allowance." ], "offsets": [ [ 0, 146 ] ] } ]
[ { "id": "DS.d1002.s0.e0", "type": "compound", "text": [ "Cortisol" ], "offsets": [ [ 0, 8 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5754" } ] }, { "id": "DS.d1002.s0.e1", "type": "protein", "text": [ "aspartate aminotransferase" ], "offsets": [ [ 67, 93 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O33822" }, { "db_name": "UniProt", "db_id": "O58489" }, { "db_name": "UniProt", "db_id": "O67781" }, { "db_name": "UniProt", "db_id": "O86459" }, { "db_name": "UniProt", "db_id": "O93744" }, { "db_name": "UniProt", "db_id": "P00509" }, { "db_name": "UniProt", "db_id": "P14909" }, { "db_name": "UniProt", "db_id": "P23034" }, { "db_name": "UniProt", "db_id": "P44425" }, { "db_name": "UniProt", "db_id": "P53001" }, { "db_name": "UniProt", "db_id": "P58661" }, { "db_name": "UniProt", "db_id": "P72173" }, { "db_name": "UniProt", "db_id": "Q4J8X2" }, { "db_name": "UniProt", "db_id": "Q55128" }, { "db_name": "UniProt", "db_id": "Q56114" }, { "db_name": "UniProt", "db_id": "Q56232" }, { "db_name": "UniProt", "db_id": "Q59228" }, { "db_name": "UniProt", "db_id": "Q60013" }, { "db_name": "UniProt", "db_id": "Q92JE7" }, { "db_name": "UniProt", "db_id": "Q972A2" }, { "db_name": "UniProt", "db_id": "Q9V0L2" }, { "db_name": "UniProt", "db_id": "Q9X0Y2" }, { "db_name": "UniProt", "db_id": "Q9ZE56" } ] } ]
[]
[]
[]
DS.d1003
18766172
[ { "id": "DS.d1003.s0", "type": "", "text": [ "At 2 h in suspension, keratinocytes that had become committed to terminal differentiation had increased side scatter, were 7-aminoactinomycin D (7-AAD) positive and annexin V negative; they exhibited loss of mitochondrial membrane potential and increased cardiolipin oxidation, but with no increase in reactive oxygen species." ], "offsets": [ [ 0, 326 ] ] } ]
[ { "id": "DS.d1003.s0.e0", "type": "compound", "text": [ "7-aminoactinomycin D" ], "offsets": [ [ 123, 143 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65180" } ] }, { "id": "DS.d1003.s0.e1", "type": "protein", "text": [ "AAD" ], "offsets": [ [ 147, 150 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P23670" }, { "db_name": "UniProt", "db_id": "P81336" }, { "db_name": "UniProt", "db_id": "Q01752" }, { "db_name": "UniProt", "db_id": "Q7NSA6" }, { "db_name": "UniProt", "db_id": "Q8XR10" }, { "db_name": "UniProt", "db_id": "Q9EYI7" }, { "db_name": "UniProt", "db_id": "Q9RPK1" } ] }, { "id": "DS.d1003.s0.e2", "type": "protein", "text": [ "annexin V" ], "offsets": [ [ 165, 174 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08758" }, { "db_name": "UniProt", "db_id": "P14668" }, { "db_name": "UniProt", "db_id": "P17153" }, { "db_name": "UniProt", "db_id": "P48036" }, { "db_name": "UniProt", "db_id": "P70075" }, { "db_name": "UniProt", "db_id": "P81287" }, { "db_name": "UniProt", "db_id": "Q4R4H7" }, { "db_name": "UniProt", "db_id": "Q5R1W0" } ] } ]
[]
[]
[]
DS.d1004
18766385
[ { "id": "DS.d1004.s0", "type": "", "text": [ "Iron uptake by the ubiquitous iron-storage protein ferritin involves the oxidation of two Fe(II) ions located at the highly conserved dinuclear \" ferroxidase centre\" in individual subunits." ], "offsets": [ [ 0, 189 ] ] }, { "id": "DS.d1004.s1", "type": "", "text": [ "We have measured X-ray absorption spectra of four mutants (K86Q, K86Q/E27D, K86Q/E107D, and K86Q/E27D/E107D, involving variations of Glu to Asp on either or both sides of the dinuclear ferroxidase site) of recombinant human H-chain ferritin (rHuHF) in their complexes with reactive Fe(II) and redox-inactive Zn(II)." ], "offsets": [ [ 190, 505 ] ] } ]
[ { "id": "DS.d1004.s0.e0", "type": "protein", "text": [ "ferritin" ], "offsets": [ [ 51, 59 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q26061" } ] }, { "id": "DS.d1004.s0.e1", "type": "compound", "text": [ "Fe(II" ], "offsets": [ [ 90, 95 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "27284" } ] }, { "id": "DS.d1004.s0.e2", "type": "protein", "text": [ "ferroxidase" ], "offsets": [ [ 146, 157 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00450" }, { "db_name": "UniProt", "db_id": "P13635" }, { "db_name": "UniProt", "db_id": "Q61147" }, { "db_name": "UniProt", "db_id": "Q9XT27" } ] }, { "id": "DS.d1004.s1.e0", "type": "protein", "text": [ "ferroxidase" ], "offsets": [ [ 375, 386 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00450" }, { "db_name": "UniProt", "db_id": "P13635" }, { "db_name": "UniProt", "db_id": "Q61147" }, { "db_name": "UniProt", "db_id": "Q9XT27" } ] }, { "id": "DS.d1004.s1.e1", "type": "protein", "text": [ "ferritin" ], "offsets": [ [ 422, 430 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q26061" } ] }, { "id": "DS.d1004.s1.e2", "type": "compound", "text": [ "Fe(II" ], "offsets": [ [ 472, 477 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "27284" } ] }, { "id": "DS.d1004.s1.e3", "type": "compound", "text": [ "Zn(II" ], "offsets": [ [ 498, 503 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "32051" } ] } ]
[]
[]
[ { "id": "DS.d1004.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1004.s0.e1", "arg2_id": "DS.d1004.s0.e2", "normalized": [] }, { "id": "DS.d1004.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1004.s0.e1", "arg2_id": "DS.d1004.s0.e0", "normalized": [] }, { "id": "DS.d1004.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1004.s1.e3", "arg2_id": "DS.d1004.s1.e1", "normalized": [] }, { "id": "DS.d1004.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1004.s1.e2", "arg2_id": "DS.d1004.s1.e0", "normalized": [] }, { "id": "DS.d1004.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1004.s1.e3", "arg2_id": "DS.d1004.s1.e0", "normalized": [] }, { "id": "DS.d1004.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1004.s1.e2", "arg2_id": "DS.d1004.s1.e1", "normalized": [] } ]
DS.d1005
18766955
[ { "id": "DS.d1005.s0", "type": "", "text": [ "The aim of this study was to determine the effect of spironolactone on endothelial function in anti-tumour necrosis factor (TNF)-naive RA patients." ], "offsets": [ [ 0, 147 ] ] } ]
[ { "id": "DS.d1005.s0.e0", "type": "compound", "text": [ "spironolactone" ], "offsets": [ [ 53, 67 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5833" } ] }, { "id": "DS.d1005.s0.e1", "type": "protein", "text": [ "TNF" ], "offsets": [ [ 124, 127 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] } ]
[]
[]
[ { "id": "DS.d1005.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1005.s0.e0", "arg2_id": "DS.d1005.s0.e1", "normalized": [] } ]
DS.d1006
18767058
[ { "id": "DS.d1006.s0", "type": "", "text": [ "Compared with nonperfused constructs, flow perfused constructs demonstrated improved cells proliferation and differentiation according to cell viability, glucose consumption, alkaline phosphatase activity, and osteopontin." ], "offsets": [ [ 0, 222 ] ] } ]
[ { "id": "DS.d1006.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 154, 161 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1006.s0.e1", "type": "protein", "text": [ "alkaline phosphatase" ], "offsets": [ [ 175, 195 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60109" }, { "db_name": "UniProt", "db_id": "P81800" }, { "db_name": "UniProt", "db_id": "P83456" } ] } ]
[]
[]
[]
DS.d1007
18767059
[ { "id": "DS.d1007.s0", "type": "", "text": [ "Behavior of rat periodontal ligament cells on fibroblast growth factor-2-immobilized titanium surfaces treated by plasma modification." ], "offsets": [ [ 0, 134 ] ] }, { "id": "DS.d1007.s1", "type": "", "text": [ "The aim of this study was to investigate the behavior of rat periodontal ligament (PDL) cells cultured on fibroblast growth factor-2 (FGF-2)-immobilized titanium surfaces treated by oxygen (O2) plasma." ], "offsets": [ [ 135, 336 ] ] }, { "id": "DS.d1007.s2", "type": "", "text": [ "These were treated with oxygen plasma and dipped in FGF-2 solution." ], "offsets": [ [ 337, 404 ] ] }, { "id": "DS.d1007.s3", "type": "", "text": [ "Cells from fourth subculture were seeded onto the FGF-2-immobilized titanium surface." ], "offsets": [ [ 405, 490 ] ] }, { "id": "DS.d1007.s4", "type": "", "text": [ "These findings suggest that oxygen plasma modification can immobilize FGF-2 onto a titanium surface." ], "offsets": [ [ 491, 591 ] ] } ]
[ { "id": "DS.d1007.s0.e0", "type": "protein", "text": [ "fibroblast growth factor-2" ], "offsets": [ [ 46, 72 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q60487" } ] }, { "id": "DS.d1007.s0.e1", "type": "compound", "text": [ "titanium" ], "offsets": [ [ 85, 93 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23963" } ] }, { "id": "DS.d1007.s1.e0", "type": "protein", "text": [ "fibroblast growth factor-2" ], "offsets": [ [ 241, 267 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q60487" } ] }, { "id": "DS.d1007.s1.e1", "type": "protein", "text": [ "FGF-2" ], "offsets": [ [ 269, 274 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03969" }, { "db_name": "UniProt", "db_id": "P20003" }, { "db_name": "UniProt", "db_id": "P48800" }, { "db_name": "UniProt", "db_id": "Q60487" } ] }, { "id": "DS.d1007.s1.e2", "type": "compound", "text": [ "titanium" ], "offsets": [ [ 288, 296 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23963" } ] }, { "id": "DS.d1007.s1.e3", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 317, 323 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] }, { "id": "DS.d1007.s1.e4", "type": "compound", "text": [ "O2" ], "offsets": [ [ 325, 327 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" }, { "db_name": "PubChem", "db_id": "5359597" } ] }, { "id": "DS.d1007.s2.e0", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 361, 367 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] }, { "id": "DS.d1007.s2.e1", "type": "protein", "text": [ "FGF-2" ], "offsets": [ [ 389, 394 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03969" }, { "db_name": "UniProt", "db_id": "P20003" }, { "db_name": "UniProt", "db_id": "P48800" }, { "db_name": "UniProt", "db_id": "Q60487" } ] }, { "id": "DS.d1007.s3.e0", "type": "protein", "text": [ "FGF-2" ], "offsets": [ [ 455, 460 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03969" }, { "db_name": "UniProt", "db_id": "P20003" }, { "db_name": "UniProt", "db_id": "P48800" }, { "db_name": "UniProt", "db_id": "Q60487" } ] }, { "id": "DS.d1007.s3.e1", "type": "compound", "text": [ "titanium" ], "offsets": [ [ 473, 481 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23963" } ] }, { "id": "DS.d1007.s4.e0", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 519, 525 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] }, { "id": "DS.d1007.s4.e1", "type": "protein", "text": [ "FGF-2" ], "offsets": [ [ 561, 566 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03969" }, { "db_name": "UniProt", "db_id": "P20003" }, { "db_name": "UniProt", "db_id": "P48800" }, { "db_name": "UniProt", "db_id": "Q60487" } ] }, { "id": "DS.d1007.s4.e2", "type": "compound", "text": [ "titanium" ], "offsets": [ [ 574, 582 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23963" } ] } ]
[]
[]
[ { "id": "DS.d1007.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1007.s0.e1", "arg2_id": "DS.d1007.s0.e0", "normalized": [] }, { "id": "DS.d1007.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1007.s1.e3", "arg2_id": "DS.d1007.s1.e1", "normalized": [] }, { "id": "DS.d1007.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1007.s1.e4", "arg2_id": "DS.d1007.s1.e1", "normalized": [] }, { "id": "DS.d1007.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1007.s1.e3", "arg2_id": "DS.d1007.s1.e0", "normalized": [] }, { "id": "DS.d1007.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1007.s1.e2", "arg2_id": "DS.d1007.s1.e1", "normalized": [] }, { "id": "DS.d1007.s1.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d1007.s1.e4", "arg2_id": "DS.d1007.s1.e0", "normalized": [] }, { "id": "DS.d1007.s1.i5", "type": "compound-protein-interaction", "arg1_id": "DS.d1007.s1.e2", "arg2_id": "DS.d1007.s1.e0", "normalized": [] }, { "id": "DS.d1007.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1007.s3.e1", "arg2_id": "DS.d1007.s3.e0", "normalized": [] }, { "id": "DS.d1007.s4.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1007.s4.e0", "arg2_id": "DS.d1007.s4.e1", "normalized": [] }, { "id": "DS.d1007.s4.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1007.s4.e2", "arg2_id": "DS.d1007.s4.e1", "normalized": [] } ]
DS.d1008
18767063
[ { "id": "DS.d1008.s0", "type": "", "text": [ "One of the best triads for bone engineering is bone marrow stromal cells, calcium phosphate ceramics, and bone morphogenetic protein (BMP)." ], "offsets": [ [ 0, 139 ] ] }, { "id": "DS.d1008.s1", "type": "", "text": [ "The cells were mixed with beta-tricalcium phosphate (beta-TCP) granules followed by osteoblast induction with recombinant human BMP-2 (rhBMP-2) (first mixture), or were first induced with rhBMP-2 on plastic dishes and then mixed with the beta-TCP granules (last mixture) just prior to the operation." ], "offsets": [ [ 140, 439 ] ] } ]
[ { "id": "DS.d1008.s0.e0", "type": "compound", "text": [ "calcium phosphate" ], "offsets": [ [ 74, 91 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24441" }, { "db_name": "PubChem", "db_id": "24456" }, { "db_name": "PubChem", "db_id": "24632" } ] }, { "id": "DS.d1008.s0.e1", "type": "protein", "text": [ "morphogenetic protein" ], "offsets": [ [ 111, 132 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07580" } ] }, { "id": "DS.d1008.s0.e2", "type": "protein", "text": [ "BMP" ], "offsets": [ [ 134, 137 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P35855" } ] }, { "id": "DS.d1008.s1.e0", "type": "compound", "text": [ "beta-tricalcium phosphate" ], "offsets": [ [ 166, 191 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24456" } ] }, { "id": "DS.d1008.s1.e1", "type": "protein", "text": [ "BMP-2" ], "offsets": [ [ 268, 273 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19006" }, { "db_name": "UniProt", "db_id": "O46564" }, { "db_name": "UniProt", "db_id": "P12643" }, { "db_name": "UniProt", "db_id": "P21274" }, { "db_name": "UniProt", "db_id": "P49001" }, { "db_name": "UniProt", "db_id": "Q804S2" }, { "db_name": "UniProt", "db_id": "Q90751" } ] } ]
[]
[]
[]
DS.d1009
18767136
[ { "id": "DS.d1009.s0", "type": "", "text": [ "Effect of short-time exposures to nickel and lead on brain monoamine oxidase from Danio rerio and Poecilia reticulata." ], "offsets": [ [ 0, 118 ] ] }, { "id": "DS.d1009.s1", "type": "", "text": [ "The aim of this work was to verify, in two small size freshwater teleosts Danio rerio and Poecilia reticulata, the effects of short-time exposures (24 and 72 h) to a sublethal dose (500 microg/L) of nickel and lead, on brain monoamine oxidase (MAO), an important neural enzyme." ], "offsets": [ [ 119, 396 ] ] } ]
[ { "id": "DS.d1009.s0.e0", "type": "compound", "text": [ "nickel" ], "offsets": [ [ 34, 40 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "935" } ] }, { "id": "DS.d1009.s0.e1", "type": "protein", "text": [ "monoamine oxidase" ], "offsets": [ [ 59, 76 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P49253" } ] }, { "id": "DS.d1009.s1.e0", "type": "compound", "text": [ "nickel" ], "offsets": [ [ 318, 324 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "935" } ] }, { "id": "DS.d1009.s1.e1", "type": "protein", "text": [ "monoamine oxidase" ], "offsets": [ [ 344, 361 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P49253" } ] }, { "id": "DS.d1009.s1.e2", "type": "protein", "text": [ "MAO" ], "offsets": [ [ 363, 366 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P49253" } ] } ]
[]
[]
[ { "id": "DS.d1009.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1009.s0.e0", "arg2_id": "DS.d1009.s0.e1", "normalized": [] }, { "id": "DS.d1009.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1009.s1.e0", "arg2_id": "DS.d1009.s1.e2", "normalized": [] }, { "id": "DS.d1009.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1009.s1.e0", "arg2_id": "DS.d1009.s1.e1", "normalized": [] } ]
DS.d1010
18767138
[ { "id": "DS.d1010.s0", "type": "", "text": [ "Methylenetetrahydrofolate dehydrogenase) methenyltetrahydrofolate cyclohydrolase) formyltetrahydrofolate synthetase (MTHFD1) is a trifunctional enzyme that interconverts tetrahydrofolate (THF) derivatives for nucleotide synthesis." ], "offsets": [ [ 0, 230 ] ] } ]
[ { "id": "DS.d1010.s0.e0", "type": "protein", "text": [ "Methylenetetrahydrofolate dehydrogenase" ], "offsets": [ [ 0, 39 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O84081" }, { "db_name": "UniProt", "db_id": "O96553" }, { "db_name": "UniProt", "db_id": "P07245" }, { "db_name": "UniProt", "db_id": "P09440" }, { "db_name": "UniProt", "db_id": "P11586" }, { "db_name": "UniProt", "db_id": "P24186" }, { "db_name": "UniProt", "db_id": "P27653" }, { "db_name": "UniProt", "db_id": "P44313" }, { "db_name": "UniProt", "db_id": "P47259" }, { "db_name": "UniProt", "db_id": "P51696" }, { "db_name": "UniProt", "db_id": "P54382" }, { "db_name": "UniProt", "db_id": "P55818" }, { "db_name": "UniProt", "db_id": "P56467" }, { "db_name": "UniProt", "db_id": "P57557" }, { "db_name": "UniProt", "db_id": "P58688" }, { "db_name": "UniProt", "db_id": "P75096" }, { "db_name": "UniProt", "db_id": "P96050" }, { "db_name": "UniProt", "db_id": "Q05213" }, { "db_name": "UniProt", "db_id": "Q27772" }, { "db_name": "UniProt", "db_id": "Q60006" }, { "db_name": "UniProt", "db_id": "Q89A92" }, { "db_name": "UniProt", "db_id": "Q8K979" }, { "db_name": "UniProt", "db_id": "Q922D8" }, { "db_name": "UniProt", "db_id": "Q92HY4" }, { "db_name": "UniProt", "db_id": "Q9PKW1" }, { "db_name": "UniProt", "db_id": "Q9Z8K3" }, { "db_name": "UniProt", "db_id": "Q9ZD32" }, { "db_name": "UniProt", "db_id": "Q9ZLQ4" } ] }, { "id": "DS.d1010.s0.e1", "type": "protein", "text": [ "methenyltetrahydrofolate cyclohydrolase" ], "offsets": [ [ 41, 80 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O84081" }, { "db_name": "UniProt", "db_id": "O96553" }, { "db_name": "UniProt", "db_id": "P07245" }, { "db_name": "UniProt", "db_id": "P09440" }, { "db_name": "UniProt", "db_id": "P11586" }, { "db_name": "UniProt", "db_id": "P13995" }, { "db_name": "UniProt", "db_id": "P18155" }, { "db_name": "UniProt", "db_id": "P24186" }, { "db_name": "UniProt", "db_id": "P27653" }, { "db_name": "UniProt", "db_id": "P44313" }, { "db_name": "UniProt", "db_id": "P47259" }, { "db_name": "UniProt", "db_id": "P51696" }, { "db_name": "UniProt", "db_id": "P54382" }, { "db_name": "UniProt", "db_id": "P56467" }, { "db_name": "UniProt", "db_id": "P57557" }, { "db_name": "UniProt", "db_id": "P58688" }, { "db_name": "UniProt", "db_id": "P75096" }, { "db_name": "UniProt", "db_id": "P96050" }, { "db_name": "UniProt", "db_id": "Q04448" }, { "db_name": "UniProt", "db_id": "Q05213" }, { "db_name": "UniProt", "db_id": "Q27772" }, { "db_name": "UniProt", "db_id": "Q49135" }, { "db_name": "UniProt", "db_id": "Q5ZKA5" }, { "db_name": "UniProt", "db_id": "Q60006" }, { "db_name": "UniProt", "db_id": "Q89A92" }, { "db_name": "UniProt", "db_id": "Q8K979" }, { "db_name": "UniProt", "db_id": "Q922D8" }, { "db_name": "UniProt", "db_id": "Q92HY4" }, { "db_name": "UniProt", "db_id": "Q9PKW1" }, { "db_name": "UniProt", "db_id": "Q9Z8K3" }, { "db_name": "UniProt", "db_id": "Q9ZD32" }, { "db_name": "UniProt", "db_id": "Q9ZLQ4" } ] }, { "id": "DS.d1010.s0.e2", "type": "protein", "text": [ "formyltetrahydrofolate synthetase" ], "offsets": [ [ 82, 115 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O66164" }, { "db_name": "UniProt", "db_id": "O96553" }, { "db_name": "UniProt", "db_id": "P07245" }, { "db_name": "UniProt", "db_id": "P09440" }, { "db_name": "UniProt", "db_id": "P11586" }, { "db_name": "UniProt", "db_id": "P13419" }, { "db_name": "UniProt", "db_id": "P21164" }, { "db_name": "UniProt", "db_id": "P27653" }, { "db_name": "UniProt", "db_id": "P28723" }, { "db_name": "UniProt", "db_id": "Q07064" }, { "db_name": "UniProt", "db_id": "Q27772" }, { "db_name": "UniProt", "db_id": "Q3Z8K3" }, { "db_name": "UniProt", "db_id": "Q3ZX40" }, { "db_name": "UniProt", "db_id": "Q4FL49" }, { "db_name": "UniProt", "db_id": "Q4JVW2" }, { "db_name": "UniProt", "db_id": "Q4L776" }, { "db_name": "UniProt", "db_id": "Q59925" }, { "db_name": "UniProt", "db_id": "Q5E3V8" }, { "db_name": "UniProt", "db_id": "Q5FAG1" }, { "db_name": "UniProt", "db_id": "Q5HF42" }, { "db_name": "UniProt", "db_id": "Q5HNH4" }, { "db_name": "UniProt", "db_id": "Q5LD60" }, { "db_name": "UniProt", "db_id": "Q5LNV0" }, { "db_name": "UniProt", "db_id": "Q5M083" }, { "db_name": "UniProt", "db_id": "Q5M4U2" }, { "db_name": "UniProt", "db_id": "Q5NQC7" }, { "db_name": "UniProt", "db_id": "Q5V5Y2" }, { "db_name": "UniProt", "db_id": "Q5XZD9" }, { "db_name": "UniProt", "db_id": "Q605Q9" }, { "db_name": "UniProt", "db_id": "Q63C61" }, { "db_name": "UniProt", "db_id": "Q64U80" }, { "db_name": "UniProt", "db_id": "Q65IA6" }, { "db_name": "UniProt", "db_id": "Q67JH9" }, { "db_name": "UniProt", "db_id": "Q6ABS5" }, { "db_name": "UniProt", "db_id": "Q6AL19" }, { "db_name": "UniProt", "db_id": "Q6G8J5" }, { "db_name": "UniProt", "db_id": "Q6GFX6" }, { "db_name": "UniProt", "db_id": "Q6HJK9" }, { "db_name": "UniProt", "db_id": "Q6KZM3" }, { "db_name": "UniProt", "db_id": "Q6LNJ0" }, { "db_name": "UniProt", "db_id": "Q6NH87" }, { "db_name": "UniProt", "db_id": "Q71YD9" }, { "db_name": "UniProt", "db_id": "Q72GY9" }, { "db_name": "UniProt", "db_id": "Q739F4" }, { "db_name": "UniProt", "db_id": "Q73RR6" }, { "db_name": "UniProt", "db_id": "Q74JC1" }, { "db_name": "UniProt", "db_id": "Q7A535" }, { "db_name": "UniProt", "db_id": "Q7MEE8" }, { "db_name": "UniProt", "db_id": "Q7MUZ8" }, { "db_name": "UniProt", "db_id": "Q7VLW6" }, { "db_name": "UniProt", "db_id": "Q81E87" }, { "db_name": "UniProt", "db_id": "Q81RE1" }, { "db_name": "UniProt", "db_id": "Q834D6" }, { "db_name": "UniProt", "db_id": "Q83WS0" }, { "db_name": "UniProt", "db_id": "Q87HX2" }, { "db_name": "UniProt", "db_id": "Q88W76" }, { "db_name": "UniProt", "db_id": "Q891R3" }, { "db_name": "UniProt", "db_id": "Q8A9S8" }, { "db_name": "UniProt", "db_id": "Q8CNV9" }, { "db_name": "UniProt", "db_id": "Q8D7D8" }, { "db_name": "UniProt", "db_id": "Q8DPL5" }, { "db_name": "UniProt", "db_id": "Q8DZP5" }, { "db_name": "UniProt", "db_id": "Q8E5E3" }, { "db_name": "UniProt", "db_id": "Q8EJA7" }, { "db_name": "UniProt", "db_id": "Q8EUQ1" }, { "db_name": "UniProt", "db_id": "Q8G700" }, { "db_name": "UniProt", "db_id": "Q8NW37" }, { "db_name": "UniProt", "db_id": "Q8R7L3" }, { "db_name": "UniProt", "db_id": "Q8RHF4" }, { "db_name": "UniProt", "db_id": "Q8XHL4" }, { "db_name": "UniProt", "db_id": "Q8Y624" }, { "db_name": "UniProt", "db_id": "Q922D8" }, { "db_name": "UniProt", "db_id": "Q92AD2" }, { "db_name": "UniProt", "db_id": "Q92N42" }, { "db_name": "UniProt", "db_id": "Q97CL3" }, { "db_name": "UniProt", "db_id": "Q97EB3" }, { "db_name": "UniProt", "db_id": "Q97QI2" }, { "db_name": "UniProt", "db_id": "Q98HQ4" }, { "db_name": "UniProt", "db_id": "Q99TD2" }, { "db_name": "UniProt", "db_id": "Q9CH07" }, { "db_name": "UniProt", "db_id": "Q9HI67" }, { "db_name": "UniProt", "db_id": "Q9JVY8" }, { "db_name": "UniProt", "db_id": "Q9JXY2" }, { "db_name": "UniProt", "db_id": "Q9KLX7" }, { "db_name": "UniProt", "db_id": "Q9PQS1" }, { "db_name": "UniProt", "db_id": "Q9SPK5" }, { "db_name": "UniProt", "db_id": "Q9X287" } ] }, { "id": "DS.d1010.s0.e3", "type": "protein", "text": [ "MTHFD1" ], "offsets": [ [ 117, 123 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11586" } ] }, { "id": "DS.d1010.s0.e4", "type": "compound", "text": [ "tetrahydrofolate" ], "offsets": [ [ 9, 25 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "91443" } ] } ]
[]
[]
[ { "id": "DS.d1010.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1010.s0.e4", "arg2_id": "DS.d1010.s0.e1", "normalized": [] }, { "id": "DS.d1010.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1010.s0.e4", "arg2_id": "DS.d1010.s0.e3", "normalized": [] }, { "id": "DS.d1010.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1010.s0.e4", "arg2_id": "DS.d1010.s0.e0", "normalized": [] }, { "id": "DS.d1010.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1010.s0.e4", "arg2_id": "DS.d1010.s0.e2", "normalized": [] } ]
DS.d1011
18767147
[ { "id": "DS.d1011.s0", "type": "", "text": [ "An oncogenetic tree model was built using data on mutations of TP53, KRAS2, APC, and BRAF genes, methylation at CpG sites of MLH1 and TP16 genes, methylation in tumor (MINT) markers, and microsatellite instability (MSI) for 971 colon tumors from a population-based series." ], "offsets": [ [ 0, 272 ] ] } ]
[ { "id": "DS.d1011.s0.e0", "type": "protein", "text": [ "TP53" ], "offsets": [ [ 63, 67 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O09185" }, { "db_name": "UniProt", "db_id": "O12946" }, { "db_name": "UniProt", "db_id": "O36006" }, { "db_name": "UniProt", "db_id": "O57538" }, { "db_name": "UniProt", "db_id": "O93379" }, { "db_name": "UniProt", "db_id": "P04637" }, { "db_name": "UniProt", "db_id": "P10360" }, { "db_name": "UniProt", "db_id": "P13481" }, { "db_name": "UniProt", "db_id": "P25035" }, { "db_name": "UniProt", "db_id": "P41685" }, { "db_name": "UniProt", "db_id": "P51664" }, { "db_name": "UniProt", "db_id": "P56423" }, { "db_name": "UniProt", "db_id": "P56424" }, { "db_name": "UniProt", "db_id": "P61260" }, { "db_name": "UniProt", "db_id": "P67938" }, { "db_name": "UniProt", "db_id": "P67939" }, { "db_name": "UniProt", "db_id": "P79820" }, { "db_name": "UniProt", "db_id": "P79892" }, { "db_name": "UniProt", "db_id": "Q00366" }, { "db_name": "UniProt", "db_id": "Q29480" }, { "db_name": "UniProt", "db_id": "Q29537" }, { "db_name": "UniProt", "db_id": "Q64662" }, { "db_name": "UniProt", "db_id": "Q8SPZ3" }, { "db_name": "UniProt", "db_id": "Q92143" }, { "db_name": "UniProt", "db_id": "Q95330" }, { "db_name": "UniProt", "db_id": "Q9TTA1" }, { "db_name": "UniProt", "db_id": "Q9TUB2" }, { "db_name": "UniProt", "db_id": "Q9W678" }, { "db_name": "UniProt", "db_id": "Q9W679" }, { "db_name": "UniProt", "db_id": "Q9WUR6" } ] }, { "id": "DS.d1011.s0.e1", "type": "protein", "text": [ "KRAS2" ], "offsets": [ [ 69, 74 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01116" } ] }, { "id": "DS.d1011.s0.e2", "type": "protein", "text": [ "APC" ], "offsets": [ [ 76, 79 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P25054" } ] }, { "id": "DS.d1011.s0.e3", "type": "protein", "text": [ "BRAF" ], "offsets": [ [ 85, 89 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15056" }, { "db_name": "UniProt", "db_id": "P34908" }, { "db_name": "UniProt", "db_id": "Q04982" } ] }, { "id": "DS.d1011.s0.e4", "type": "compound", "text": [ "CpG" ], "offsets": [ [ 112, 115 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6804" } ] }, { "id": "DS.d1011.s0.e5", "type": "protein", "text": [ "MLH1" ], "offsets": [ [ 125, 129 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P38920" }, { "db_name": "UniProt", "db_id": "P40692" } ] } ]
[]
[]
[ { "id": "DS.d1011.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1011.s0.e4", "arg2_id": "DS.d1011.s0.e5", "normalized": [] } ]
DS.d1012
18767149
[ { "id": "DS.d1012.s0", "type": "", "text": [ "We characterized this selenoprotein MsrA which had a single Sec residue at the catalytic site but no cysteine (Cys) residues in the protein sequence." ], "offsets": [ [ 0, 149 ] ] } ]
[ { "id": "DS.d1012.s0.e0", "type": "protein", "text": [ "MsrA" ], "offsets": [ [ 36, 40 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O25011" }, { "db_name": "UniProt", "db_id": "O26635" }, { "db_name": "UniProt", "db_id": "O69761" }, { "db_name": "UniProt", "db_id": "O83641" }, { "db_name": "UniProt", "db_id": "P0A081" }, { "db_name": "UniProt", "db_id": "P0A082" }, { "db_name": "UniProt", "db_id": "P0A083" }, { "db_name": "UniProt", "db_id": "P0A084" }, { "db_name": "UniProt", "db_id": "P0A085" }, { "db_name": "UniProt", "db_id": "P0A086" }, { "db_name": "UniProt", "db_id": "P0A3Q9" }, { "db_name": "UniProt", "db_id": "P0A3R0" }, { "db_name": "UniProt", "db_id": "P0A5L0" }, { "db_name": "UniProt", "db_id": "P0A5L1" }, { "db_name": "UniProt", "db_id": "P0A744" }, { "db_name": "UniProt", "db_id": "P0A745" }, { "db_name": "UniProt", "db_id": "P23212" }, { "db_name": "UniProt", "db_id": "P47648" }, { "db_name": "UniProt", "db_id": "P54154" }, { "db_name": "UniProt", "db_id": "P65443" }, { "db_name": "UniProt", "db_id": "P65444" }, { "db_name": "UniProt", "db_id": "P75188" }, { "db_name": "UniProt", "db_id": "Q4J9L3" }, { "db_name": "UniProt", "db_id": "Q53W34" }, { "db_name": "UniProt", "db_id": "Q576P8" }, { "db_name": "UniProt", "db_id": "Q5HG58" }, { "db_name": "UniProt", "db_id": "Q5HVD4" }, { "db_name": "UniProt", "db_id": "Q5PJ81" }, { "db_name": "UniProt", "db_id": "Q5XDH1" }, { "db_name": "UniProt", "db_id": "Q66F89" }, { "db_name": "UniProt", "db_id": "Q6D151" }, { "db_name": "UniProt", "db_id": "Q6L2S4" }, { "db_name": "UniProt", "db_id": "Q6LV65" }, { "db_name": "UniProt", "db_id": "Q6LYY1" }, { "db_name": "UniProt", "db_id": "Q6NEL2" }, { "db_name": "UniProt", "db_id": "Q71YF6" }, { "db_name": "UniProt", "db_id": "Q746G0" }, { "db_name": "UniProt", "db_id": "Q7MYW1" }, { "db_name": "UniProt", "db_id": "Q87D27" }, { "db_name": "UniProt", "db_id": "Q87SW6" }, { "db_name": "UniProt", "db_id": "Q88AI5" }, { "db_name": "UniProt", "db_id": "Q88QZ8" }, { "db_name": "UniProt", "db_id": "Q899M3" }, { "db_name": "UniProt", "db_id": "Q8DE84" }, { "db_name": "UniProt", "db_id": "Q8DSY4" }, { "db_name": "UniProt", "db_id": "Q8DYH1" }, { "db_name": "UniProt", "db_id": "Q8E434" }, { "db_name": "UniProt", "db_id": "Q8FAG4" }, { "db_name": "UniProt", "db_id": "Q8FLU6" }, { "db_name": "UniProt", "db_id": "Q8FUZ0" }, { "db_name": "UniProt", "db_id": "Q8NLL5" }, { "db_name": "UniProt", "db_id": "Q8P272" }, { "db_name": "UniProt", "db_id": "Q8PCA6" }, { "db_name": "UniProt", "db_id": "Q8PNY8" }, { "db_name": "UniProt", "db_id": "Q8PUD6" }, { "db_name": "UniProt", "db_id": "Q8TQV6" }, { "db_name": "UniProt", "db_id": "Q8VS50" }, { "db_name": "UniProt", "db_id": "Q8XCG3" }, { "db_name": "UniProt", "db_id": "Q8XH97" }, { "db_name": "UniProt", "db_id": "Q8Y1C6" }, { "db_name": "UniProt", "db_id": "Q8Y640" }, { "db_name": "UniProt", "db_id": "Q8YDE7" }, { "db_name": "UniProt", "db_id": "Q8Z150" }, { "db_name": "UniProt", "db_id": "Q8ZB94" }, { "db_name": "UniProt", "db_id": "Q8ZK71" }, { "db_name": "UniProt", "db_id": "Q92AE8" }, { "db_name": "UniProt", "db_id": "Q93KF3" }, { "db_name": "UniProt", "db_id": "Q93S39" }, { "db_name": "UniProt", "db_id": "Q97MV3" }, { "db_name": "UniProt", "db_id": "Q97Y45" }, { "db_name": "UniProt", "db_id": "Q98PE5" }, { "db_name": "UniProt", "db_id": "Q99YT1" }, { "db_name": "UniProt", "db_id": "Q9A149" }, { "db_name": "UniProt", "db_id": "Q9AJF7" }, { "db_name": "UniProt", "db_id": "Q9APY4" }, { "db_name": "UniProt", "db_id": "Q9CCZ3" }, { "db_name": "UniProt", "db_id": "Q9CN40" }, { "db_name": "UniProt", "db_id": "Q9EWF7" }, { "db_name": "UniProt", "db_id": "Q9HQG0" }, { "db_name": "UniProt", "db_id": "Q9HUF1" }, { "db_name": "UniProt", "db_id": "Q9KAN8" }, { "db_name": "UniProt", "db_id": "Q9KP30" }, { "db_name": "UniProt", "db_id": "Q9LAM9" }, { "db_name": "UniProt", "db_id": "Q9PC45" }, { "db_name": "UniProt", "db_id": "Q9PQK2" }, { "db_name": "UniProt", "db_id": "Q9RTB6" }, { "db_name": "UniProt", "db_id": "Q9ZEQ8" }, { "db_name": "UniProt", "db_id": "Q9ZMK8" } ] }, { "id": "DS.d1012.s0.e1", "type": "compound", "text": [ "cysteine" ], "offsets": [ [ 101, 109 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "594" }, { "db_name": "PubChem", "db_id": "5862" }, { "db_name": "PubChem", "db_id": "5360637" } ] } ]
[]
[]
[]
DS.d1013
18767150
[ { "id": "DS.d1013.s0", "type": "", "text": [ "Zn2+-linked dimerization of UreG from Helicobacter pylori, a chaperone involved in nickel trafficking and urease activation." ], "offsets": [ [ 0, 124 ] ] }, { "id": "DS.d1013.s1", "type": "", "text": [ "The biosynthesis of the active metal-bound form of the nickel-dependent enzyme urease involves the formation of a lysine-carbamate functional group concomitantly with the delivery of two Ni(2+) ions into the precast active site of the apoenzyme and with GTP hydrolysis." ], "offsets": [ [ 125, 394 ] ] } ]
[ { "id": "DS.d1013.s0.e0", "type": "protein", "text": [ "UreG" ], "offsets": [ [ 28, 32 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54424" }, { "db_name": "UniProt", "db_id": "P0A4R7" }, { "db_name": "UniProt", "db_id": "P0A4R8" }, { "db_name": "UniProt", "db_id": "P0A664" }, { "db_name": "UniProt", "db_id": "P0A665" }, { "db_name": "UniProt", "db_id": "P18319" }, { "db_name": "UniProt", "db_id": "P42871" }, { "db_name": "UniProt", "db_id": "P42877" }, { "db_name": "UniProt", "db_id": "P44396" }, { "db_name": "UniProt", "db_id": "P69992" }, { "db_name": "UniProt", "db_id": "P69993" }, { "db_name": "UniProt", "db_id": "P72955" }, { "db_name": "UniProt", "db_id": "Q03287" }, { "db_name": "UniProt", "db_id": "Q06206" }, { "db_name": "UniProt", "db_id": "Q07403" }, { "db_name": "UniProt", "db_id": "Q09066" }, { "db_name": "UniProt", "db_id": "Q55057" }, { "db_name": "UniProt", "db_id": "Q56561" }, { "db_name": "UniProt", "db_id": "Q9ZMZ7" } ] }, { "id": "DS.d1013.s0.e1", "type": "compound", "text": [ "nickel" ], "offsets": [ [ 83, 89 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "935" } ] }, { "id": "DS.d1013.s0.e2", "type": "protein", "text": [ "urease" ], "offsets": [ [ 106, 112 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00084" }, { "db_name": "UniProt", "db_id": "O13465" }, { "db_name": "UniProt", "db_id": "P07374" }, { "db_name": "UniProt", "db_id": "P08298" }, { "db_name": "UniProt", "db_id": "Q5KCQ6" }, { "db_name": "UniProt", "db_id": "Q6A3P9" } ] }, { "id": "DS.d1013.s1.e0", "type": "protein", "text": [ "urease" ], "offsets": [ [ 204, 210 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00084" }, { "db_name": "UniProt", "db_id": "O13465" }, { "db_name": "UniProt", "db_id": "P07374" }, { "db_name": "UniProt", "db_id": "P08298" }, { "db_name": "UniProt", "db_id": "Q5KCQ6" }, { "db_name": "UniProt", "db_id": "Q6A3P9" } ] }, { "id": "DS.d1013.s1.e1", "type": "compound", "text": [ "lysine" ], "offsets": [ [ 239, 245 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "866" }, { "db_name": "PubChem", "db_id": "5962" } ] }, { "id": "DS.d1013.s1.e2", "type": "compound", "text": [ "carbamate" ], "offsets": [ [ 246, 255 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "277" } ] }, { "id": "DS.d1013.s1.e3", "type": "compound", "text": [ "Ni(2" ], "offsets": [ [ 312, 316 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "934" } ] } ]
[]
[]
[ { "id": "DS.d1013.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1013.s0.e1", "arg2_id": "DS.d1013.s0.e0", "normalized": [] }, { "id": "DS.d1013.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1013.s1.e1", "arg2_id": "DS.d1013.s1.e0", "normalized": [] }, { "id": "DS.d1013.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1013.s1.e3", "arg2_id": "DS.d1013.s1.e0", "normalized": [] }, { "id": "DS.d1013.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1013.s1.e2", "arg2_id": "DS.d1013.s1.e0", "normalized": [] } ]
DS.d1014
18767155
[ { "id": "DS.d1014.s0", "type": "", "text": [ "Residue-wise conformational stability of DLC8 dimer from native-state hydrogen exchange." ], "offsets": [ [ 0, 88 ] ] } ]
[ { "id": "DS.d1014.s0.e0", "type": "protein", "text": [ "DLC8" ], "offsets": [ [ 41, 45 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P63167" }, { "db_name": "UniProt", "db_id": "P63168" }, { "db_name": "UniProt", "db_id": "P63169" }, { "db_name": "UniProt", "db_id": "P63170" }, { "db_name": "UniProt", "db_id": "Q9D0M5" } ] }, { "id": "DS.d1014.s0.e1", "type": "compound", "text": [ "hydrogen" ], "offsets": [ [ 70, 78 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "783" } ] } ]
[]
[]
[ { "id": "DS.d1014.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1014.s0.e1", "arg2_id": "DS.d1014.s0.e0", "normalized": [] } ]
DS.d1015
18767934
[ { "id": "DS.d1015.s0", "type": "", "text": [ "Whereas the role of locally produced 1, 25-dihydroxyvitamin D is not yet clear, it is possible that it contributes importantly to vitamin D-mediated inhibition of parathyroid cell growth, so CYP27B1 can be considered a candidate parathyroid tumor suppressor gene in that its acquired inactivation in a parathyroid cell could confer a tumorigenic growth advantage." ], "offsets": [ [ 0, 363 ] ] } ]
[ { "id": "DS.d1015.s0.e0", "type": "compound", "text": [ "25-dihydroxyvitamin D" ], "offsets": [ [ 40, 61 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5283731" }, { "db_name": "PubChem", "db_id": "6433735" } ] }, { "id": "DS.d1015.s0.e1", "type": "compound", "text": [ "vitamin D" ], "offsets": [ [ 52, 61 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280795" } ] }, { "id": "DS.d1015.s0.e2", "type": "protein", "text": [ "CYP27B1" ], "offsets": [ [ 191, 198 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O15528" } ] } ]
[]
[]
[]
DS.d1016
18768213
[ { "id": "DS.d1016.s0", "type": "", "text": [ "Mechanistically, we showed EphA2 knockdown suppressed thrombin-induced serine 536 phosphorylation of NFkappaB, an event critical of ICAM-1 transcriptional upregulation." ], "offsets": [ [ 0, 168 ] ] } ]
[ { "id": "DS.d1016.s0.e0", "type": "protein", "text": [ "thrombin" ], "offsets": [ [ 54, 62 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P84122" } ] }, { "id": "DS.d1016.s0.e1", "type": "compound", "text": [ "serine" ], "offsets": [ [ 71, 77 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5951" } ] }, { "id": "DS.d1016.s0.e2", "type": "protein", "text": [ "ICAM-1" ], "offsets": [ [ 132, 138 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05362" }, { "db_name": "UniProt", "db_id": "P13597" }, { "db_name": "UniProt", "db_id": "P33729" }, { "db_name": "UniProt", "db_id": "Q00238" }, { "db_name": "UniProt", "db_id": "Q28806" }, { "db_name": "UniProt", "db_id": "Q5NKV4" }, { "db_name": "UniProt", "db_id": "Q5NKV6" }, { "db_name": "UniProt", "db_id": "Q5NKV9" }, { "db_name": "UniProt", "db_id": "Q95132" } ] } ]
[]
[]
[ { "id": "DS.d1016.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1016.s0.e1", "arg2_id": "DS.d1016.s0.e0", "normalized": [] }, { "id": "DS.d1016.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1016.s0.e1", "arg2_id": "DS.d1016.s0.e2", "normalized": [] } ]
DS.d1017
18768362
[ { "id": "DS.d1017.s0", "type": "", "text": [ "Total antioxidant capacity, catalase, thiobarbituric acid-reactive substances, hemoglobin, transferrin saturation and ferritin did not change significantly." ], "offsets": [ [ 0, 156 ] ] } ]
[ { "id": "DS.d1017.s0.e0", "type": "protein", "text": [ "catalase" ], "offsets": [ [ 28, 36 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24339" }, { "db_name": "UniProt", "db_id": "O52762" }, { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O68146" }, { "db_name": "UniProt", "db_id": "O77229" }, { "db_name": "UniProt", "db_id": "O93662" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P04762" }, { "db_name": "UniProt", "db_id": "P07145" }, { "db_name": "UniProt", "db_id": "P0A323" }, { "db_name": "UniProt", "db_id": "P0A324" }, { "db_name": "UniProt", "db_id": "P0A325" }, { "db_name": "UniProt", "db_id": "P0A326" }, { "db_name": "UniProt", "db_id": "P0A327" }, { "db_name": "UniProt", "db_id": "P11934" }, { "db_name": "UniProt", "db_id": "P17336" }, { "db_name": "UniProt", "db_id": "P24168" }, { "db_name": "UniProt", "db_id": "P24270" }, { "db_name": "UniProt", "db_id": "P25890" }, { "db_name": "UniProt", "db_id": "P29422" }, { "db_name": "UniProt", "db_id": "P30265" }, { "db_name": "UniProt", "db_id": "P30266" }, { "db_name": "UniProt", "db_id": "P32290" }, { "db_name": "UniProt", "db_id": "P42321" }, { "db_name": "UniProt", "db_id": "P44390" }, { "db_name": "UniProt", "db_id": "P45737" }, { "db_name": "UniProt", "db_id": "P45739" }, { "db_name": "UniProt", "db_id": "P55304" }, { "db_name": "UniProt", "db_id": "P55306" }, { "db_name": "UniProt", "db_id": "P55310" }, { "db_name": "UniProt", "db_id": "P55311" }, { "db_name": "UniProt", "db_id": "P55313" }, { "db_name": "UniProt", "db_id": "P77872" }, { "db_name": "UniProt", "db_id": "P81138" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q27710" }, { "db_name": "UniProt", "db_id": "Q49XC1" }, { "db_name": "UniProt", "db_id": "Q4L643" }, { "db_name": "UniProt", "db_id": "Q59296" }, { "db_name": "UniProt", "db_id": "Q59337" }, { "db_name": "UniProt", "db_id": "Q59602" }, { "db_name": "UniProt", "db_id": "Q59714" }, { "db_name": "UniProt", "db_id": "Q5HG86" }, { "db_name": "UniProt", "db_id": "Q5HPK8" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q6G9M4" }, { "db_name": "UniProt", "db_id": "Q6GH72" }, { "db_name": "UniProt", "db_id": "Q7A5T2" }, { "db_name": "UniProt", "db_id": "Q8CPD0" }, { "db_name": "UniProt", "db_id": "Q8FWU0" }, { "db_name": "UniProt", "db_id": "Q8NWV5" }, { "db_name": "UniProt", "db_id": "Q8X1P0" }, { "db_name": "UniProt", "db_id": "Q8Y3P9" }, { "db_name": "UniProt", "db_id": "Q926X0" }, { "db_name": "UniProt", "db_id": "Q99UE2" }, { "db_name": "UniProt", "db_id": "Q9AXH0" }, { "db_name": "UniProt", "db_id": "Q9KW19" }, { "db_name": "UniProt", "db_id": "Q9L4S1" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PT92" }, { "db_name": "UniProt", "db_id": "Q9PWF7" }, { "db_name": "UniProt", "db_id": "Q9Z598" }, { "db_name": "UniProt", "db_id": "Q9ZKX5" }, { "db_name": "UniProt", "db_id": "Q9ZN99" } ] }, { "id": "DS.d1017.s0.e1", "type": "compound", "text": [ "thiobarbituric acid" ], "offsets": [ [ 38, 57 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2723628" } ] }, { "id": "DS.d1017.s0.e2", "type": "protein", "text": [ "hemoglobin" ], "offsets": [ [ 79, 89 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15160" }, { "db_name": "UniProt", "db_id": "P17724" }, { "db_name": "UniProt", "db_id": "P73925" }, { "db_name": "UniProt", "db_id": "Q03459" } ] }, { "id": "DS.d1017.s0.e3", "type": "protein", "text": [ "transferrin" ], "offsets": [ [ 91, 102 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02787" }, { "db_name": "UniProt", "db_id": "P09571" }, { "db_name": "UniProt", "db_id": "P12346" }, { "db_name": "UniProt", "db_id": "P19134" }, { "db_name": "UniProt", "db_id": "P27425" }, { "db_name": "UniProt", "db_id": "Q29443" }, { "db_name": "UniProt", "db_id": "Q921I1" } ] }, { "id": "DS.d1017.s0.e4", "type": "protein", "text": [ "ferritin" ], "offsets": [ [ 118, 126 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q26061" } ] } ]
[]
[]
[]
DS.d1018
18768916
[ { "id": "DS.d1018.s0", "type": "", "text": [ "Considering the post-cAMP sites of HA action, it is shown herein that HA markedly inhibited db-cAMP-stimulated steroidogenic acute regulatory (STAR) protein expression, as well as steps catalyzed by P450-dependent enzymes, mainly the conversion of cholesterol to pregnenolone by cholesterol side-chain cleavage enzyme (CYP11A)." ], "offsets": [ [ 0, 327 ] ] }, { "id": "DS.d1018.s1", "type": "", "text": [ "Finally, HA increased nitric oxide synthase (NOS) activity, and the NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME) markedly attenuated the effect of the amine on steroid synthesis." ], "offsets": [ [ 328, 517 ] ] } ]
[ { "id": "DS.d1018.s0.e0", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 248, 259 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d1018.s0.e1", "type": "compound", "text": [ "pregnenolone" ], "offsets": [ [ 263, 275 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "8955" } ] }, { "id": "DS.d1018.s0.e2", "type": "protein", "text": [ "cholesterol side-chain cleavage enzyme" ], "offsets": [ [ 279, 317 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46515" }, { "db_name": "UniProt", "db_id": "P00189" }, { "db_name": "UniProt", "db_id": "P05108" }, { "db_name": "UniProt", "db_id": "P10612" }, { "db_name": "UniProt", "db_id": "P14137" }, { "db_name": "UniProt", "db_id": "P79153" }, { "db_name": "UniProt", "db_id": "P79202" }, { "db_name": "UniProt", "db_id": "Q07217" }, { "db_name": "UniProt", "db_id": "Q28827" }, { "db_name": "UniProt", "db_id": "Q2XV99" }, { "db_name": "UniProt", "db_id": "Q92045" }, { "db_name": "UniProt", "db_id": "Q9EPT4" }, { "db_name": "UniProt", "db_id": "Q9QZ82" } ] }, { "id": "DS.d1018.s0.e3", "type": "protein", "text": [ "CYP11A" ], "offsets": [ [ 319, 325 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05108" }, { "db_name": "UniProt", "db_id": "Q2XV99" }, { "db_name": "UniProt", "db_id": "Q9EPT4" } ] }, { "id": "DS.d1018.s1.e0", "type": "protein", "text": [ "nitric oxide synthase" ], "offsets": [ [ 350, 371 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q27571" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] }, { "id": "DS.d1018.s1.e1", "type": "compound", "text": [ "L-arginine methyl ester" ], "offsets": [ [ 419, 442 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "550788" } ] } ]
[]
[]
[ { "id": "DS.d1018.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1018.s0.e1", "arg2_id": "DS.d1018.s0.e3", "normalized": [] }, { "id": "DS.d1018.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1018.s0.e0", "arg2_id": "DS.d1018.s0.e2", "normalized": [] }, { "id": "DS.d1018.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1018.s0.e0", "arg2_id": "DS.d1018.s0.e3", "normalized": [] }, { "id": "DS.d1018.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1018.s0.e1", "arg2_id": "DS.d1018.s0.e2", "normalized": [] } ]
DS.d1019
18769443
[ { "id": "DS.d1019.s0", "type": "", "text": [ "LH, FSH, 17 beta-estradiol, progesterone, aldosterone and PRA were assayed at the seventh, fourteenth, twenty-first and twenty-eighth days of the cycle after 30 min of recumbency." ], "offsets": [ [ 0, 179 ] ] }, { "id": "DS.d1019.s1", "type": "", "text": [ "Aldosterone was positively related to PRA and progesterone." ], "offsets": [ [ 180, 239 ] ] } ]
[ { "id": "DS.d1019.s0.e0", "type": "compound", "text": [ "beta-estradiol" ], "offsets": [ [ 12, 26 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5757" } ] }, { "id": "DS.d1019.s0.e1", "type": "compound", "text": [ "progesterone" ], "offsets": [ [ 28, 40 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5994" } ] }, { "id": "DS.d1019.s0.e2", "type": "protein", "text": [ "PRA" ], "offsets": [ [ 58, 61 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06703" }, { "db_name": "UniProt", "db_id": "P10977" } ] }, { "id": "DS.d1019.s1.e0", "type": "protein", "text": [ "PRA" ], "offsets": [ [ 218, 221 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06703" }, { "db_name": "UniProt", "db_id": "P10977" } ] }, { "id": "DS.d1019.s1.e1", "type": "compound", "text": [ "progesterone" ], "offsets": [ [ 226, 238 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5994" } ] } ]
[]
[]
[]
DS.d1020
18769474
[ { "id": "DS.d1020.s0", "type": "", "text": [ "COMT activity and proline levels may therefore be altered in 22q11DS individuals." ], "offsets": [ [ 0, 81 ] ] }, { "id": "DS.d1020.s1", "type": "", "text": [ "COMT (158) genotype and plasma proline levels were determined in the 22q11DS children." ], "offsets": [ [ 82, 168 ] ] } ]
[ { "id": "DS.d1020.s0.e0", "type": "protein", "text": [ "COMT" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O23760" }, { "db_name": "UniProt", "db_id": "O81646" }, { "db_name": "UniProt", "db_id": "O82054" }, { "db_name": "UniProt", "db_id": "P21964" }, { "db_name": "UniProt", "db_id": "P28002" }, { "db_name": "UniProt", "db_id": "P46484" }, { "db_name": "UniProt", "db_id": "Q06509" }, { "db_name": "UniProt", "db_id": "Q06528" }, { "db_name": "UniProt", "db_id": "Q43239" }, { "db_name": "UniProt", "db_id": "Q43609" }, { "db_name": "UniProt", "db_id": "Q6ZD89" }, { "db_name": "UniProt", "db_id": "Q8GU25" }, { "db_name": "UniProt", "db_id": "Q8LL87" }, { "db_name": "UniProt", "db_id": "Q8W013" }, { "db_name": "UniProt", "db_id": "Q99028" }, { "db_name": "UniProt", "db_id": "Q9FQY8" }, { "db_name": "UniProt", "db_id": "Q9SWC2" } ] }, { "id": "DS.d1020.s0.e1", "type": "compound", "text": [ "proline" ], "offsets": [ [ 18, 25 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "614" }, { "db_name": "PubChem", "db_id": "8988" }, { "db_name": "PubChem", "db_id": "145742" } ] }, { "id": "DS.d1020.s1.e0", "type": "protein", "text": [ "COMT" ], "offsets": [ [ 82, 86 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O23760" }, { "db_name": "UniProt", "db_id": "O81646" }, { "db_name": "UniProt", "db_id": "O82054" }, { "db_name": "UniProt", "db_id": "P21964" }, { "db_name": "UniProt", "db_id": "P28002" }, { "db_name": "UniProt", "db_id": "P46484" }, { "db_name": "UniProt", "db_id": "Q06509" }, { "db_name": "UniProt", "db_id": "Q06528" }, { "db_name": "UniProt", "db_id": "Q43239" }, { "db_name": "UniProt", "db_id": "Q43609" }, { "db_name": "UniProt", "db_id": "Q6ZD89" }, { "db_name": "UniProt", "db_id": "Q8GU25" }, { "db_name": "UniProt", "db_id": "Q8LL87" }, { "db_name": "UniProt", "db_id": "Q8W013" }, { "db_name": "UniProt", "db_id": "Q99028" }, { "db_name": "UniProt", "db_id": "Q9FQY8" }, { "db_name": "UniProt", "db_id": "Q9SWC2" } ] }, { "id": "DS.d1020.s1.e1", "type": "compound", "text": [ "proline" ], "offsets": [ [ 113, 120 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "614" }, { "db_name": "PubChem", "db_id": "8988" }, { "db_name": "PubChem", "db_id": "145742" } ] } ]
[]
[]
[]
DS.d1021
18769875
[ { "id": "DS.d1021.s0", "type": "", "text": [ "We have investigated its antibacterial activity and binding activity to pathogenic whole cell antigens, lipopolysaccharide (LPS) and staphylococcal enterotoxin B." ], "offsets": [ [ 0, 162 ] ] } ]
[ { "id": "DS.d1021.s0.e0", "type": "compound", "text": [ "lipopolysaccharide" ], "offsets": [ [ 104, 122 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11970143" } ] }, { "id": "DS.d1021.s0.e1", "type": "protein", "text": [ "enterotoxin B" ], "offsets": [ [ 148, 161 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P22542" } ] } ]
[]
[]
[]
DS.d1022
18770028
[ { "id": "DS.d1022.s0", "type": "", "text": [ "Quinone formation is closely linked to other representative hypotheses such as mitochondrial dysfunction, inflammation, oxidative stress, and dysfunction of the ubiquitin-proteasome system, in the pathogenesis of neurodegenerative diseases such as Parkinson's disease and methamphetamine-induced neurotoxicity." ], "offsets": [ [ 0, 310 ] ] } ]
[ { "id": "DS.d1022.s0.e0", "type": "protein", "text": [ "ubiquitin" ], "offsets": [ [ 161, 170 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46543" }, { "db_name": "UniProt", "db_id": "P08565" }, { "db_name": "UniProt", "db_id": "P08618" }, { "db_name": "UniProt", "db_id": "P0C014" }, { "db_name": "UniProt", "db_id": "P0C072" }, { "db_name": "UniProt", "db_id": "P13117" }, { "db_name": "UniProt", "db_id": "P14624" }, { "db_name": "UniProt", "db_id": "P14792" }, { "db_name": "UniProt", "db_id": "P15174" }, { "db_name": "UniProt", "db_id": "P19848" }, { "db_name": "UniProt", "db_id": "P20685" }, { "db_name": "UniProt", "db_id": "P22589" }, { "db_name": "UniProt", "db_id": "P23324" }, { "db_name": "UniProt", "db_id": "P23398" }, { "db_name": "UniProt", "db_id": "P42739" }, { "db_name": "UniProt", "db_id": "P42740" }, { "db_name": "UniProt", "db_id": "P46574" }, { "db_name": "UniProt", "db_id": "P49634" }, { "db_name": "UniProt", "db_id": "P49635" }, { "db_name": "UniProt", "db_id": "P59263" }, { "db_name": "UniProt", "db_id": "P59669" }, { "db_name": "UniProt", "db_id": "P61862" }, { "db_name": "UniProt", "db_id": "P61863" }, { "db_name": "UniProt", "db_id": "P61864" }, { "db_name": "UniProt", "db_id": "P62972" }, { "db_name": "UniProt", "db_id": "P62973" }, { "db_name": "UniProt", "db_id": "P62974" }, { "db_name": "UniProt", "db_id": "P62975" }, { "db_name": "UniProt", "db_id": "P62976" }, { "db_name": "UniProt", "db_id": "P62977" }, { "db_name": "UniProt", "db_id": "P62988" }, { "db_name": "UniProt", "db_id": "P62989" }, { "db_name": "UniProt", "db_id": "P62990" }, { "db_name": "UniProt", "db_id": "P62991" }, { "db_name": "UniProt", "db_id": "P63049" }, { "db_name": "UniProt", "db_id": "P63051" }, { "db_name": "UniProt", "db_id": "P68195" }, { "db_name": "UniProt", "db_id": "P68196" }, { "db_name": "UniProt", "db_id": "P68197" }, { "db_name": "UniProt", "db_id": "P68198" }, { "db_name": "UniProt", "db_id": "P68199" }, { "db_name": "UniProt", "db_id": "P68201" }, { "db_name": "UniProt", "db_id": "P68204" }, { "db_name": "UniProt", "db_id": "P69308" }, { "db_name": "UniProt", "db_id": "P69309" }, { "db_name": "UniProt", "db_id": "P69310" }, { "db_name": "UniProt", "db_id": "P69311" }, { "db_name": "UniProt", "db_id": "P69312" }, { "db_name": "UniProt", "db_id": "P69313" }, { "db_name": "UniProt", "db_id": "P69314" }, { "db_name": "UniProt", "db_id": "P69315" }, { "db_name": "UniProt", "db_id": "P69316" }, { "db_name": "UniProt", "db_id": "P69317" }, { "db_name": "UniProt", "db_id": "P69318" }, { "db_name": "UniProt", "db_id": "P69319" }, { "db_name": "UniProt", "db_id": "P69320" }, { "db_name": "UniProt", "db_id": "P69321" }, { "db_name": "UniProt", "db_id": "P69322" }, { "db_name": "UniProt", "db_id": "P69323" }, { "db_name": "UniProt", "db_id": "P69324" }, { "db_name": "UniProt", "db_id": "P69325" }, { "db_name": "UniProt", "db_id": "P69326" }, { "db_name": "UniProt", "db_id": "P84589" }, { "db_name": "UniProt", "db_id": "Q05550" }, { "db_name": "UniProt", "db_id": "Q865C5" }, { "db_name": "UniProt", "db_id": "Q867C2" }, { "db_name": "UniProt", "db_id": "Q867C3" }, { "db_name": "UniProt", "db_id": "Q867C4" }, { "db_name": "UniProt", "db_id": "Q8MKD1" }, { "db_name": "UniProt", "db_id": "Q9Y848" } ] }, { "id": "DS.d1022.s0.e1", "type": "compound", "text": [ "methamphetamine" ], "offsets": [ [ 272, 287 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1206" }, { "db_name": "PubChem", "db_id": "10836" }, { "db_name": "PubChem", "db_id": "36604" } ] } ]
[]
[]
[]
DS.d1023
18771337
[ { "id": "DS.d1023.s0", "type": "", "text": [ "The effect of fenitrothion exposure on birds was examined by measuring aerobic metabolism, blood hemoglobin content, plasma cholinesterases, and body weight for up to 21 d postdose." ], "offsets": [ [ 0, 181 ] ] } ]
[ { "id": "DS.d1023.s0.e0", "type": "compound", "text": [ "fenitrothion" ], "offsets": [ [ 14, 26 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "31200" } ] }, { "id": "DS.d1023.s0.e1", "type": "protein", "text": [ "hemoglobin" ], "offsets": [ [ 97, 107 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15160" }, { "db_name": "UniProt", "db_id": "P17724" }, { "db_name": "UniProt", "db_id": "P73925" }, { "db_name": "UniProt", "db_id": "Q03459" } ] }, { "id": "DS.d1023.s0.e2", "type": "protein", "text": [ "cholinesterases" ], "offsets": [ [ 124, 139 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P32749" }, { "db_name": "UniProt", "db_id": "P32750" }, { "db_name": "UniProt", "db_id": "P32751" }, { "db_name": "UniProt", "db_id": "P32752" }, { "db_name": "UniProt", "db_id": "P32753" }, { "db_name": "UniProt", "db_id": "P81908" } ] } ]
[]
[]
[ { "id": "DS.d1023.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1023.s0.e0", "arg2_id": "DS.d1023.s0.e2", "normalized": [] }, { "id": "DS.d1023.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1023.s0.e0", "arg2_id": "DS.d1023.s0.e1", "normalized": [] } ]
DS.d1024
18771515
[ { "id": "DS.d1024.s0", "type": "", "text": [ "Of the 37 E. coli isolated from diarrhoeic calves, K99 (18.9%), F41 (18.9%), heat-stable enterotoxin a (STa) (18.9%), Shiga toxin 1 (Stx1; 13.5%) and Shiga toxin 2 (Stx2 ; 5.4%) and intimin (8.1%) genes were identified by multiplex PCR." ], "offsets": [ [ 0, 236 ] ] }, { "id": "DS.d1024.s1", "type": "", "text": [ "Of the 18 E. coli isolated from healthy calves, K99 (16.6%) and intimin (55.5%) genes were identified by PCR." ], "offsets": [ [ 237, 346 ] ] }, { "id": "DS.d1024.s2", "type": "", "text": [ "K99, F41, STa, Stx1 and Stx2 were found as the most common virulence gene markers of E. coli strains isolated from calves with diarrhoea." ], "offsets": [ [ 347, 484 ] ] } ]
[ { "id": "DS.d1024.s0.e0", "type": "compound", "text": [ "K99" ], "offsets": [ [ 51, 54 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "49837850" } ] }, { "id": "DS.d1024.s0.e1", "type": "compound", "text": [ "F41" ], "offsets": [ [ 64, 67 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "760826" } ] }, { "id": "DS.d1024.s0.e2", "type": "protein", "text": [ "enterotoxin" ], "offsets": [ [ 89, 100 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P54355" }, { "db_name": "UniProt", "db_id": "P80567" }, { "db_name": "UniProt", "db_id": "P80568" } ] }, { "id": "DS.d1024.s0.e3", "type": "protein", "text": [ "toxin 1" ], "offsets": [ [ 124, 131 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P45629" } ] }, { "id": "DS.d1024.s0.e4", "type": "protein", "text": [ "Stx2" ], "offsets": [ [ 165, 169 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P50279" }, { "db_name": "UniProt", "db_id": "Q00262" } ] }, { "id": "DS.d1024.s0.e5", "type": "protein", "text": [ "intimin" ], "offsets": [ [ 182, 189 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O31000" }, { "db_name": "UniProt", "db_id": "P19809" }, { "db_name": "UniProt", "db_id": "P43261" }, { "db_name": "UniProt", "db_id": "P52869" }, { "db_name": "UniProt", "db_id": "Q07591" } ] }, { "id": "DS.d1024.s0.e6", "type": "protein", "text": [ "PCR" ], "offsets": [ [ 232, 235 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O66148" }, { "db_name": "UniProt", "db_id": "O80333" }, { "db_name": "UniProt", "db_id": "P15904" }, { "db_name": "UniProt", "db_id": "Q01289" }, { "db_name": "UniProt", "db_id": "Q39617" }, { "db_name": "UniProt", "db_id": "Q41249" }, { "db_name": "UniProt", "db_id": "Q59987" }, { "db_name": "UniProt", "db_id": "Q9SDT1" } ] }, { "id": "DS.d1024.s1.e0", "type": "compound", "text": [ "K99" ], "offsets": [ [ 285, 288 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "49837850" } ] }, { "id": "DS.d1024.s1.e1", "type": "protein", "text": [ "intimin" ], "offsets": [ [ 301, 308 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O31000" }, { "db_name": "UniProt", "db_id": "P19809" }, { "db_name": "UniProt", "db_id": "P43261" }, { "db_name": "UniProt", "db_id": "P52869" }, { "db_name": "UniProt", "db_id": "Q07591" } ] }, { "id": "DS.d1024.s1.e2", "type": "protein", "text": [ "PCR" ], "offsets": [ [ 342, 345 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O66148" }, { "db_name": "UniProt", "db_id": "O80333" }, { "db_name": "UniProt", "db_id": "P15904" }, { "db_name": "UniProt", "db_id": "Q01289" }, { "db_name": "UniProt", "db_id": "Q39617" }, { "db_name": "UniProt", "db_id": "Q41249" }, { "db_name": "UniProt", "db_id": "Q59987" }, { "db_name": "UniProt", "db_id": "Q9SDT1" } ] }, { "id": "DS.d1024.s2.e0", "type": "compound", "text": [ "K99" ], "offsets": [ [ 347, 350 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "49837850" } ] }, { "id": "DS.d1024.s2.e1", "type": "compound", "text": [ "F41" ], "offsets": [ [ 352, 355 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "760826" } ] }, { "id": "DS.d1024.s2.e2", "type": "protein", "text": [ "Stx2" ], "offsets": [ [ 371, 375 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P50279" }, { "db_name": "UniProt", "db_id": "Q00262" } ] } ]
[]
[]
[]
DS.d1025
18771570
[ { "id": "DS.d1025.s0", "type": "", "text": [ "These agents possess a range of physiological effects that are associated with improved glycaemic control in diabetes including stimulation of glucose-dependent insulin secretion, suppression of glucagon secretion, slowing of gastric emptying, and reduction of food intake." ], "offsets": [ [ 0, 273 ] ] } ]
[ { "id": "DS.d1025.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 143, 150 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1025.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 161, 168 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1025.s0.e2", "type": "protein", "text": [ "glucagon" ], "offsets": [ [ 195, 203 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12956" }, { "db_name": "UniProt", "db_id": "O42143" }, { "db_name": "UniProt", "db_id": "O42144" }, { "db_name": "UniProt", "db_id": "P01272" }, { "db_name": "UniProt", "db_id": "P01273" }, { "db_name": "UniProt", "db_id": "P01274" }, { "db_name": "UniProt", "db_id": "P01275" }, { "db_name": "UniProt", "db_id": "P04093" }, { "db_name": "UniProt", "db_id": "P05110" }, { "db_name": "UniProt", "db_id": "P06883" }, { "db_name": "UniProt", "db_id": "P07449" }, { "db_name": "UniProt", "db_id": "P09566" }, { "db_name": "UniProt", "db_id": "P09567" }, { "db_name": "UniProt", "db_id": "P09682" }, { "db_name": "UniProt", "db_id": "P09686" }, { "db_name": "UniProt", "db_id": "P0C235" }, { "db_name": "UniProt", "db_id": "P13189" }, { "db_name": "UniProt", "db_id": "P15438" }, { "db_name": "UniProt", "db_id": "P18108" }, { "db_name": "UniProt", "db_id": "P22890" }, { "db_name": "UniProt", "db_id": "P29794" }, { "db_name": "UniProt", "db_id": "P31297" }, { "db_name": "UniProt", "db_id": "P33528" }, { "db_name": "UniProt", "db_id": "P55095" }, { "db_name": "UniProt", "db_id": "P68259" }, { "db_name": "UniProt", "db_id": "P68260" }, { "db_name": "UniProt", "db_id": "P68273" }, { "db_name": "UniProt", "db_id": "P68274" }, { "db_name": "UniProt", "db_id": "P68275" }, { "db_name": "UniProt", "db_id": "P68952" }, { "db_name": "UniProt", "db_id": "P68953" }, { "db_name": "UniProt", "db_id": "P68954" }, { "db_name": "UniProt", "db_id": "P68955" }, { "db_name": "UniProt", "db_id": "P68956" }, { "db_name": "UniProt", "db_id": "P68957" }, { "db_name": "UniProt", "db_id": "P79695" }, { "db_name": "UniProt", "db_id": "P81880" }, { "db_name": "UniProt", "db_id": "Q8MJ25" }, { "db_name": "UniProt", "db_id": "Q9PRQ9" } ] } ]
[]
[]
[ { "id": "DS.d1025.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1025.s0.e0", "arg2_id": "DS.d1025.s0.e1", "normalized": [] } ]
DS.d1026
18771604
[ { "id": "DS.d1026.s0", "type": "", "text": [ "Induction of the spliced form of XBP1 as well as total XBP1 by thapsigargin was significantly attenuated in patients with BD." ], "offsets": [ [ 0, 125 ] ] }, { "id": "DS.d1026.s1", "type": "", "text": [ "Induction of GRP94 by thapsigargin was also decreased in the BD group." ], "offsets": [ [ 126, 196 ] ] } ]
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[]
[]
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DS.d1027
18771683
[ { "id": "DS.d1027.s0", "type": "", "text": [ "Efforts in the field of synthetic vaccine carriers are focussing on decorating the particle surface with ligands for DC receptors such as heparan sulphate glycosaminoglycan structures, integrins, Siglecs, galectins, C-type lectins and toll-like receptors." ], "offsets": [ [ 0, 255 ] ] } ]
[ { "id": "DS.d1027.s0.e0", "type": "compound", "text": [ "sulphate" ], "offsets": [ [ 146, 154 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1117" } ] }, { "id": "DS.d1027.s0.e1", "type": "protein", "text": [ "galectins" ], "offsets": [ [ 205, 214 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q801X7" } ] }, { "id": "DS.d1027.s0.e2", "type": "protein", "text": [ "lectins" ], "offsets": [ [ 207, 214 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02871" }, { "db_name": "UniProt", "db_id": "P02873" }, { "db_name": "UniProt", "db_id": "P02874" }, { "db_name": "UniProt", "db_id": "P02875" }, { "db_name": "UniProt", "db_id": "P07386" }, { "db_name": "UniProt", "db_id": "P16108" }, { "db_name": "UniProt", "db_id": "P16349" }, { "db_name": "UniProt", "db_id": "P16351" }, { "db_name": "UniProt", "db_id": "P16352" }, { "db_name": "UniProt", "db_id": "P33888" }, { "db_name": "UniProt", "db_id": "P38662" }, { "db_name": "UniProt", "db_id": "P42088" }, { "db_name": "UniProt", "db_id": "P83410" }, { "db_name": "UniProt", "db_id": "P83511" }, { "db_name": "UniProt", "db_id": "P84987" }, { "db_name": "UniProt", "db_id": "Q41114" } ] } ]
[]
[]
[]
DS.d1028
18771795
[ { "id": "DS.d1028.s0", "type": "", "text": [ "Reversal of the inhibitory effect of fondaparinux on thrombin generation by rFVIIa, aPCC and PCC." ], "offsets": [ [ 0, 97 ] ] } ]
[ { "id": "DS.d1028.s0.e0", "type": "compound", "text": [ "fondaparinux" ], "offsets": [ [ 37, 49 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5282448" } ] }, { "id": "DS.d1028.s0.e1", "type": "protein", "text": [ "thrombin" ], "offsets": [ [ 53, 61 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P84122" } ] }, { "id": "DS.d1028.s0.e2", "type": "compound", "text": [ "PCC" ], "offsets": [ [ 85, 88 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "62529" } ] } ]
[]
[]
[ { "id": "DS.d1028.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1028.s0.e0", "arg2_id": "DS.d1028.s0.e1", "normalized": [] }, { "id": "DS.d1028.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1028.s0.e2", "arg2_id": "DS.d1028.s0.e1", "normalized": [] } ]
DS.d1029
18771857
[ { "id": "DS.d1029.s0", "type": "", "text": [ "It appears that GSTM1 null and GSTT1 null have a clear association with longer overall survival in patients with different malignancies who are treated with substrates for these GSTs (mostly alkylating agents and platinum compounds)." ], "offsets": [ [ 0, 233 ] ] } ]
[ { "id": "DS.d1029.s0.e0", "type": "protein", "text": [ "GSTM1" ], "offsets": [ [ 16, 21 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P09488" }, { "db_name": "UniProt", "db_id": "P16413" }, { "db_name": "UniProt", "db_id": "Q9N0V4" }, { "db_name": "UniProt", "db_id": "Q9TSM5" } ] }, { "id": "DS.d1029.s0.e1", "type": "protein", "text": [ "GSTT1" ], "offsets": [ [ 31, 36 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20135" }, { "db_name": "UniProt", "db_id": "P30711" }, { "db_name": "UniProt", "db_id": "Q2NL00" } ] }, { "id": "DS.d1029.s0.e2", "type": "protein", "text": [ "GSTs" ], "offsets": [ [ 178, 182 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20432" }, { "db_name": "UniProt", "db_id": "P30104" }, { "db_name": "UniProt", "db_id": "P30106" }, { "db_name": "UniProt", "db_id": "P30107" }, { "db_name": "UniProt", "db_id": "P30108" }, { "db_name": "UniProt", "db_id": "Q04522" }, { "db_name": "UniProt", "db_id": "Q0ZS46" }, { "db_name": "UniProt", "db_id": "Q7REH6" }, { "db_name": "UniProt", "db_id": "Q8ILQ7" }, { "db_name": "UniProt", "db_id": "Q8MU52" } ] }, { "id": "DS.d1029.s0.e3", "type": "compound", "text": [ "platinum compounds" ], "offsets": [ [ 213, 231 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23939" } ] } ]
[]
[]
[ { "id": "DS.d1029.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1029.s0.e3", "arg2_id": "DS.d1029.s0.e2", "normalized": [] }, { "id": "DS.d1029.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1029.s0.e3", "arg2_id": "DS.d1029.s0.e1", "normalized": [] }, { "id": "DS.d1029.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1029.s0.e3", "arg2_id": "DS.d1029.s0.e0", "normalized": [] } ]
DS.d1030
18771904
[ { "id": "DS.d1030.s0", "type": "", "text": [ "Silibinin attenuates antigen-specific IgE production through the modulation of Th1/Th2 balance in ovalbumin-sensitized BALB/c mice." ], "offsets": [ [ 0, 131 ] ] }, { "id": "DS.d1030.s1", "type": "", "text": [ "BALB/c mice were either left untreated or administered daily with vehicle (VH; saline) and/or silibinin (200 or 400 mg/kg) by gavage for 3 consecutive days prior to sensitization with ovalbumin (OVA)." ], "offsets": [ [ 132, 332 ] ] } ]
[ { "id": "DS.d1030.s0.e0", "type": "compound", "text": [ "Silibinin" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5213" }, { "db_name": "PubChem", "db_id": "31553" }, { "db_name": "PubChem", "db_id": "3086637" }, { "db_name": "PubChem", "db_id": "16211710" } ] }, { "id": "DS.d1030.s0.e1", "type": "protein", "text": [ "Th1" ], "offsets": [ [ 79, 82 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q64279" }, { "db_name": "UniProt", "db_id": "Q922L6" } ] }, { "id": "DS.d1030.s1.e0", "type": "compound", "text": [ "silibinin" ], "offsets": [ [ 226, 235 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5213" }, { "db_name": "PubChem", "db_id": "31553" }, { "db_name": "PubChem", "db_id": "3086637" }, { "db_name": "PubChem", "db_id": "16211710" } ] }, { "id": "DS.d1030.s1.e1", "type": "protein", "text": [ "ovalbumin" ], "offsets": [ [ 316, 325 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O73860" }, { "db_name": "UniProt", "db_id": "P01012" }, { "db_name": "UniProt", "db_id": "P19104" }, { "db_name": "UniProt", "db_id": "Q6V115" } ] } ]
[]
[]
[ { "id": "DS.d1030.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1030.s0.e0", "arg2_id": "DS.d1030.s0.e1", "normalized": [] } ]
DS.d1031
18772236
[ { "id": "DS.d1031.s0", "type": "", "text": [ "Treatment with HG, but not equimolar mannitol or 3-O-methyl glucose, resulted in phosphorylation and activation of TNF-alpha converting enzyme (TACE) (ADAM17), which were attenuated by sorbinil or AR-specific small interference RNA." ], "offsets": [ [ 0, 232 ] ] }, { "id": "DS.d1031.s1", "type": "", "text": [ "These results indicate that HG-induced TNF-alpha shedding could be attributed to TACE activation, which is regulated, in part, by PKC-delta and AR." ], "offsets": [ [ 233, 380 ] ] } ]
[ { "id": "DS.d1031.s0.e0", "type": "compound", "text": [ "HG" ], "offsets": [ [ 15, 17 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23931" } ] }, { "id": "DS.d1031.s0.e1", "type": "compound", "text": [ "mannitol" ], "offsets": [ [ 37, 45 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6251" } ] }, { "id": "DS.d1031.s0.e2", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 60, 67 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1031.s0.e3", "type": "protein", "text": [ "TNF-alpha converting enzyme" ], "offsets": [ [ 115, 142 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O77636" }, { "db_name": "UniProt", "db_id": "P78536" }, { "db_name": "UniProt", "db_id": "Q9Z0F8" }, { "db_name": "UniProt", "db_id": "Q9Z1K9" } ] }, { "id": "DS.d1031.s0.e4", "type": "protein", "text": [ "TACE" ], "offsets": [ [ 144, 148 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O77636" }, { "db_name": "UniProt", "db_id": "P78536" } ] }, { "id": "DS.d1031.s0.e5", "type": "protein", "text": [ "ADAM17" ], "offsets": [ [ 151, 157 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O77636" }, { "db_name": "UniProt", "db_id": "P78536" } ] }, { "id": "DS.d1031.s0.e6", "type": "compound", "text": [ "sorbinil" ], "offsets": [ [ 185, 193 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "337359" } ] }, { "id": "DS.d1031.s1.e0", "type": "compound", "text": [ "HG" ], "offsets": [ [ 261, 263 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23931" } ] }, { "id": "DS.d1031.s1.e1", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 272, 281 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d1031.s1.e2", "type": "protein", "text": [ "TACE" ], "offsets": [ [ 314, 318 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O77636" }, { "db_name": "UniProt", "db_id": "P78536" } ] }, { "id": "DS.d1031.s1.e3", "type": "protein", "text": [ "PKC-delta" ], "offsets": [ [ 363, 372 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10829" } ] } ]
[]
[]
[ { "id": "DS.d1031.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1031.s0.e0", "arg2_id": "DS.d1031.s0.e5", "normalized": [] }, { "id": "DS.d1031.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1031.s0.e6", "arg2_id": "DS.d1031.s0.e3", "normalized": [] }, { "id": "DS.d1031.s0.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d1031.s0.e0", "arg2_id": "DS.d1031.s0.e3", "normalized": [] }, { "id": "DS.d1031.s0.i6", "type": "compound-protein-interaction", "arg1_id": "DS.d1031.s0.e6", "arg2_id": "DS.d1031.s0.e5", "normalized": [] }, { "id": "DS.d1031.s0.i8", "type": "compound-protein-interaction", "arg1_id": "DS.d1031.s0.e0", "arg2_id": "DS.d1031.s0.e4", "normalized": [] }, { "id": "DS.d1031.s0.i9", "type": "compound-protein-interaction", "arg1_id": "DS.d1031.s0.e6", "arg2_id": "DS.d1031.s0.e4", "normalized": [] }, { "id": "DS.d1031.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1031.s1.e0", "arg2_id": "DS.d1031.s1.e2", "normalized": [] }, { "id": "DS.d1031.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1031.s1.e0", "arg2_id": "DS.d1031.s1.e1", "normalized": [] } ]
DS.d1032
18772240
[ { "id": "DS.d1032.s0", "type": "", "text": [ "We conclude that gastrocnemius, heart, and liver mitochondria of streptozotocin diabetic rats are not irrevocably altered toward excess superoxide production either by complex I or complex III." ], "offsets": [ [ 0, 193 ] ] } ]
[ { "id": "DS.d1032.s0.e0", "type": "compound", "text": [ "superoxide" ], "offsets": [ [ 136, 146 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5359597" } ] }, { "id": "DS.d1032.s0.e1", "type": "protein", "text": [ "complex I" ], "offsets": [ [ 168, 177 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q07842" } ] } ]
[]
[]
[ { "id": "DS.d1032.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1032.s0.e0", "arg2_id": "DS.d1032.s0.e1", "normalized": [] } ]
DS.d1033
18772354
[ { "id": "DS.d1033.s0", "type": "", "text": [ "Consequently, the primary mechanism of resistance to temozolomide is a function of the activity of the DNA repair enzyme O(6)-methylguanine DNA methyltransferase (MGMT)." ], "offsets": [ [ 0, 169 ] ] } ]
[ { "id": "DS.d1033.s0.e0", "type": "compound", "text": [ "temozolomide" ], "offsets": [ [ 53, 65 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5394" } ] }, { "id": "DS.d1033.s0.e1", "type": "protein", "text": [ "methyltransferase" ], "offsets": [ [ 144, 161 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O40976" }, { "db_name": "UniProt", "db_id": "P03588" }, { "db_name": "UniProt", "db_id": "P03589" }, { "db_name": "UniProt", "db_id": "P06011" }, { "db_name": "UniProt", "db_id": "P17769" }, { "db_name": "UniProt", "db_id": "P20122" }, { "db_name": "UniProt", "db_id": "P27752" }, { "db_name": "UniProt", "db_id": "P28726" }, { "db_name": "UniProt", "db_id": "P28931" }, { "db_name": "UniProt", "db_id": "Q00020" }, { "db_name": "UniProt", "db_id": "Q66121" }, { "db_name": "UniProt", "db_id": "Q83264" }, { "db_name": "UniProt", "db_id": "Q83270" } ] }, { "id": "DS.d1033.s0.e2", "type": "protein", "text": [ "MGMT" ], "offsets": [ [ 163, 167 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O26715" }, { "db_name": "UniProt", "db_id": "O27970" }, { "db_name": "UniProt", "db_id": "O59499" }, { "db_name": "UniProt", "db_id": "O74023" }, { "db_name": "UniProt", "db_id": "O93728" }, { "db_name": "UniProt", "db_id": "P0A2U0" }, { "db_name": "UniProt", "db_id": "P0A2U1" }, { "db_name": "UniProt", "db_id": "P0A696" }, { "db_name": "UniProt", "db_id": "P0A697" }, { "db_name": "UniProt", "db_id": "P0AFH0" }, { "db_name": "UniProt", "db_id": "P0AFH1" }, { "db_name": "UniProt", "db_id": "P11742" }, { "db_name": "UniProt", "db_id": "P16455" }, { "db_name": "UniProt", "db_id": "P24528" }, { "db_name": "UniProt", "db_id": "P26186" }, { "db_name": "UniProt", "db_id": "P26187" }, { "db_name": "UniProt", "db_id": "P26188" }, { "db_name": "UniProt", "db_id": "P29177" }, { "db_name": "UniProt", "db_id": "P44687" }, { "db_name": "UniProt", "db_id": "P52982" }, { "db_name": "UniProt", "db_id": "Q4J9C6" }, { "db_name": "UniProt", "db_id": "Q58924" }, { "db_name": "UniProt", "db_id": "Q5UNU9" }, { "db_name": "UniProt", "db_id": "Q6TDU1" }, { "db_name": "UniProt", "db_id": "Q8PY44" }, { "db_name": "UniProt", "db_id": "Q8TI34" }, { "db_name": "UniProt", "db_id": "Q8TZ11" }, { "db_name": "UniProt", "db_id": "Q8TZV2" }, { "db_name": "UniProt", "db_id": "Q973C7" }, { "db_name": "UniProt", "db_id": "Q97VW7" }, { "db_name": "UniProt", "db_id": "Q9V1N7" }, { "db_name": "UniProt", "db_id": "Q9ZET8" } ] } ]
[]
[]
[ { "id": "DS.d1033.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1033.s0.e0", "arg2_id": "DS.d1033.s0.e1", "normalized": [] }, { "id": "DS.d1033.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1033.s0.e0", "arg2_id": "DS.d1033.s0.e2", "normalized": [] } ]
DS.d1034
18772483
[ { "id": "DS.d1034.s0", "type": "", "text": [ "Despite their inhibitory effects on inflammatory gene expression, loss of PPARs or LXRs in macrophages did not exert major effects on obesity or glucose tolerance induced by a high-fat diet." ], "offsets": [ [ 0, 190 ] ] }, { "id": "DS.d1034.s1", "type": "", "text": [ "Our results do not exclude a contribution of macrophage PPAR and LXR expression to systemic metabolism in certain contexts, but these factors do not appear to be dominant contributors to glucose tolerance in a high-fat-fed Th1-biased bone marrow transplant model." ], "offsets": [ [ 191, 454 ] ] } ]
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[]
[]
[]
DS.d1035
18772488
[ { "id": "DS.d1035.s0", "type": "", "text": [ "The dark side of testosterone deficiency: II. Type 2 diabetes and insulin resistance." ], "offsets": [ [ 0, 85 ] ] }, { "id": "DS.d1035.s1", "type": "", "text": [ "A considerable body of evidence exists suggesting a link among reduced testosterone plasma levels, type 2 diabetes (T2D), and insulin resistance (IR)." ], "offsets": [ [ 86, 236 ] ] }, { "id": "DS.d1035.s2", "type": "", "text": [ "Androgen therapy of hypogonadal men improves insulin sensitivity, fasting glucose, and HbA1c levels." ], "offsets": [ [ 237, 337 ] ] } ]
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"db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1035.s2.e0", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 282, 289 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1035.s2.e1", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 311, 318 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] } ]
[]
[]
[ { "id": "DS.d1035.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1035.s0.e0", "arg2_id": "DS.d1035.s0.e1", "normalized": [] }, { "id": "DS.d1035.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1035.s1.e0", "arg2_id": "DS.d1035.s1.e1", "normalized": [] } ]