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stringlengths 15
19
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| passages
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|---|---|---|---|---|---|---|
split_0_train_27700
|
split_0_train_27700
|
[
{
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"type": "progene_text",
"text": [
"Multiplicity and properties of promoters with minimum requirements for their basal activity ."
],
"offsets": [
[
0,
93
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27701
|
split_0_train_27701
|
[
{
"id": "split_0_train_27701_passage",
"type": "progene_text",
"text": [
"The mouse RFC-1 gene incorporates alternates of exon 1 ( exon 1 and 1a ) which encode different 5' ends ."
],
"offsets": [
[
0,
105
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}
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{
"id": "split_0_train_44846_entity",
"type": "progene_text",
"text": [
"RFC-1"
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"offsets": [
[
10,
15
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] |
[] |
[] |
[] |
split_0_train_27702
|
split_0_train_27702
|
[
{
"id": "split_0_train_27702_passage",
"type": "progene_text",
"text": [
"This finding , and the elucidation of a promoter - like sequence immediately upstream of these alternates of exon 1 , suggest that two separate promoters drive transcription of this gene ."
],
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0,
188
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}
] |
[] |
[] |
[] |
[] |
split_0_train_27703
|
split_0_train_27703
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[
{
"id": "split_0_train_27703_passage",
"type": "progene_text",
"text": [
"The regions upstream of either exon 1 or exon 1a inserted in pGL3 will separately promote transcription in NIH3T3 cells of the luciferase reporter gene , with the region upstream of exon 1 having the strongest promoter activity ."
],
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0,
229
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}
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{
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"type": "progene_text",
"text": [
"luciferase"
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127,
137
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}
] |
[] |
[] |
[] |
split_0_train_27704
|
split_0_train_27704
|
[
{
"id": "split_0_train_27704_passage",
"type": "progene_text",
"text": [
"Tissue - specific expression in the form of RFC-1 mRNA splice variants reflects the separate action of each promoter ."
],
"offsets": [
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0,
118
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}
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{
"id": "split_0_train_44848_entity",
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"text": [
"RFC-1"
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44,
49
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] |
[] |
[] |
[] |
split_0_train_27705
|
split_0_train_27705
|
[
{
"id": "split_0_train_27705_passage",
"type": "progene_text",
"text": [
"In the most upstream portion of the region proximal to exon 1a , elements were revealed that enhance transcription along with a more downstream element that suppresses transcription in NIH3T3 cells ."
],
"offsets": [
[
0,
199
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27706
|
split_0_train_27706
|
[
{
"id": "split_0_train_27706_passage",
"type": "progene_text",
"text": [
"Three Sp1 sites closely proximal to exon 1a within a region spanning 123 nucleotides were shown to be transcriptionally active by site - directed mutagenesis , with the middle SP1 site found to be the most important of the three in maintaining basal promoter activity ."
],
"offsets": [
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269
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{
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"id": "split_0_train_44850_entity",
"type": "progene_text",
"text": [
"SP1"
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"offsets": [
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176,
179
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27707
|
split_0_train_27707
|
[
{
"id": "split_0_train_27707_passage",
"type": "progene_text",
"text": [
"A poly ( GT ) 21 di - nucleotide repetitive element upstream of these Sp1 sites was found in a region which , when deleted , increased transcription ."
],
"offsets": [
[
0,
150
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]
}
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{
"id": "split_0_train_44851_entity",
"type": "progene_text",
"text": [
"Sp1"
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"offsets": [
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70,
73
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27708
|
split_0_train_27708
|
[
{
"id": "split_0_train_27708_passage",
"type": "progene_text",
"text": [
"In the region upstream of exon 1 , two elements were elucidated which enhanced transcription ."
],
"offsets": [
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0,
94
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27709
|
split_0_train_27709
|
[
{
"id": "split_0_train_27709_passage",
"type": "progene_text",
"text": [
"Site - directed mutagenesis showed that two adjacent SP1 sites proximal to exon 1 were equally important in sustaining basal promoter activity ."
],
"offsets": [
[
0,
144
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]
}
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[
{
"id": "split_0_train_44852_entity",
"type": "progene_text",
"text": [
"SP1"
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"offsets": [
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53,
56
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27710
|
split_0_train_27710
|
[
{
"id": "split_0_train_27710_passage",
"type": "progene_text",
"text": [
"The role of each Sp1 site in maintaining basal activity of each promoter was confirmed by DNase I footprinting analysis ."
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"offsets": [
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0,
121
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]
}
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{
"id": "split_0_train_44853_entity",
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"Sp1"
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17,
20
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"type": "progene_text",
"text": [
"DNase I"
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"offsets": [
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90,
97
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27711
|
split_0_train_27711
|
[
{
"id": "split_0_train_27711_passage",
"type": "progene_text",
"text": [
"In addition , a binding site of unknown significance was identified by this analysis within the upstream promoter sequence between the two Sp1 sites proximal to exon 1a ."
],
"offsets": [
[
0,
170
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]
}
] |
[
{
"id": "split_0_train_44855_entity",
"type": "progene_text",
"text": [
"Sp1"
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"offsets": [
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139,
142
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27712
|
split_0_train_27712
|
[
{
"id": "split_0_train_27712_passage",
"type": "progene_text",
"text": [
"These data show that both promoters regulating expression of the RFC-1 gene utilize closely spaced Sp1 sites in tandem to sustain basal transcription , at least in NIH3T3 cells , in a manner characteristic of TATA - less promoters ."
],
"offsets": [
[
0,
232
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]
}
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{
"id": "split_0_train_44856_entity",
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"text": [
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65,
70
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{
"id": "split_0_train_44857_entity",
"type": "progene_text",
"text": [
"Sp1"
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"offsets": [
[
99,
102
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27713
|
split_0_train_27713
|
[
{
"id": "split_0_train_27713_passage",
"type": "progene_text",
"text": [
"Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus ."
],
"offsets": [
[
0,
91
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]
}
] |
[
{
"id": "split_0_train_44858_entity",
"type": "progene_text",
"text": [
"Cfi1"
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0,
4
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{
"id": "split_0_train_44859_entity",
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"text": [
"Cdc14"
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55,
60
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{
"id": "split_0_train_44860_entity",
"type": "progene_text",
"text": [
"phosphatase"
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"offsets": [
[
61,
72
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27714
|
split_0_train_27714
|
[
{
"id": "split_0_train_27714_passage",
"type": "progene_text",
"text": [
"In eukaryotes , the activation of mitotic cyclin - dependent kinases ( CDKs ) induces mitosis , and their inactivation causes cells to leave mitosis ."
],
"offsets": [
[
0,
150
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]
}
] |
[
{
"id": "split_0_train_44861_entity",
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"text": [
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42,
68
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{
"id": "split_0_train_44862_entity",
"type": "progene_text",
"text": [
"CDKs"
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"offsets": [
[
71,
75
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27715
|
split_0_train_27715
|
[
{
"id": "split_0_train_27715_passage",
"type": "progene_text",
"text": [
"In budding yeast , two redundant mechanisms induce the inactivation of mitotic CDKs ."
],
"offsets": [
[
0,
85
]
]
}
] |
[
{
"id": "split_0_train_44863_entity",
"type": "progene_text",
"text": [
"CDKs"
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"offsets": [
[
79,
83
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27716
|
split_0_train_27716
|
[
{
"id": "split_0_train_27716_passage",
"type": "progene_text",
"text": [
"In one mechanism , a specialized ubiquitin - dependent proteolytic system ( called the APC - dependent proteolysis machinery ) degrades the mitotic ( Clb ) cyclin subunit ."
],
"offsets": [
[
0,
172
]
]
}
] |
[
{
"id": "split_0_train_44864_entity",
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"text": [
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33,
42
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"id": "split_0_train_44865_entity",
"type": "progene_text",
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"APC"
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87,
90
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{
"id": "split_0_train_44866_entity",
"type": "progene_text",
"text": [
"( Clb ) cyclin"
],
"offsets": [
[
148,
162
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27717
|
split_0_train_27717
|
[
{
"id": "split_0_train_27717_passage",
"type": "progene_text",
"text": [
"In the other , the kinase - inhibitor Sic1 binds to mitotic CDKs and inhibits their kinase activity ."
],
"offsets": [
[
0,
101
]
]
}
] |
[
{
"id": "split_0_train_44867_entity",
"type": "progene_text",
"text": [
"kinase"
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19,
25
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{
"id": "split_0_train_44868_entity",
"type": "progene_text",
"text": [
"Sic1"
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38,
42
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{
"id": "split_0_train_44869_entity",
"type": "progene_text",
"text": [
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60,
64
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{
"id": "split_0_train_44870_entity",
"type": "progene_text",
"text": [
"kinase"
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"offsets": [
[
84,
90
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27718
|
split_0_train_27718
|
[
{
"id": "split_0_train_27718_passage",
"type": "progene_text",
"text": [
"The highly conserved protein phosphatase Cdc14 promotes both Clb degradation and Sic1 accumulation ."
],
"offsets": [
[
0,
100
]
]
}
] |
[
{
"id": "split_0_train_44871_entity",
"type": "progene_text",
"text": [
"Cdc14"
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41,
46
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{
"id": "split_0_train_44872_entity",
"type": "progene_text",
"text": [
"Clb"
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61,
64
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},
{
"id": "split_0_train_44873_entity",
"type": "progene_text",
"text": [
"Sic1"
],
"offsets": [
[
81,
85
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27719
|
split_0_train_27719
|
[
{
"id": "split_0_train_27719_passage",
"type": "progene_text",
"text": [
"Cdc14 promotes SIC1 transcription and the stabilization of Sic1 protein by dephosphorylating Sicl and its transcription factor Swi5 ."
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "split_0_train_44874_entity",
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"offsets": [
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0,
5
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{
"id": "split_0_train_44875_entity",
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"text": [
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15,
19
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{
"id": "split_0_train_44876_entity",
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"text": [
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59,
63
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{
"id": "split_0_train_44877_entity",
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"text": [
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93,
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},
{
"id": "split_0_train_44878_entity",
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106,
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{
"id": "split_0_train_44879_entity",
"type": "progene_text",
"text": [
"Swi5"
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"offsets": [
[
127,
131
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27720
|
split_0_train_27720
|
[
{
"id": "split_0_train_27720_passage",
"type": "progene_text",
"text": [
"Cdc14 activates the degradation of Clb cyclins by dephosphorylating the APC - specificity factor Cdh1 ."
],
"offsets": [
[
0,
103
]
]
}
] |
[
{
"id": "split_0_train_44880_entity",
"type": "progene_text",
"text": [
"Cdc14"
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"offsets": [
[
0,
5
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],
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},
{
"id": "split_0_train_44881_entity",
"type": "progene_text",
"text": [
"Clb cyclins"
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35,
46
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],
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},
{
"id": "split_0_train_44882_entity",
"type": "progene_text",
"text": [
"APC"
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72,
75
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],
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},
{
"id": "split_0_train_44883_entity",
"type": "progene_text",
"text": [
"Cdh1"
],
"offsets": [
[
97,
101
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27721
|
split_0_train_27721
|
[
{
"id": "split_0_train_27721_passage",
"type": "progene_text",
"text": [
"So how is Cdc14 regulated ?"
],
"offsets": [
[
0,
27
]
]
}
] |
[
{
"id": "split_0_train_44884_entity",
"type": "progene_text",
"text": [
"Cdc14"
],
"offsets": [
[
10,
15
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27722
|
split_0_train_27722
|
[
{
"id": "split_0_train_27722_passage",
"type": "progene_text",
"text": [
"Here we show that Cdc14 is sequestered in the nucleolus for most of the cell cycle ."
],
"offsets": [
[
0,
84
]
]
}
] |
[
{
"id": "split_0_train_44885_entity",
"type": "progene_text",
"text": [
"Cdc14"
],
"offsets": [
[
18,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27723
|
split_0_train_27723
|
[
{
"id": "split_0_train_27723_passage",
"type": "progene_text",
"text": [
"During nuclear division , Cdc14 is released from the nucleolus , allowing it to reach its targets ."
],
"offsets": [
[
0,
99
]
]
}
] |
[
{
"id": "split_0_train_44886_entity",
"type": "progene_text",
"text": [
"Cdc14"
],
"offsets": [
[
26,
31
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27724
|
split_0_train_27724
|
[
{
"id": "split_0_train_27724_passage",
"type": "progene_text",
"text": [
"A highly conserved signalling cascade , critical for the exit from mitosis , is required for this movement of Cdc14 during anaphase ."
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "split_0_train_44887_entity",
"type": "progene_text",
"text": [
"Cdc14"
],
"offsets": [
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110,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27725
|
split_0_train_27725
|
[
{
"id": "split_0_train_27725_passage",
"type": "progene_text",
"text": [
"Furthermore , we have identified a negative regulator of Cdc14 , Cfi1 , that anchors Cdc14 in the nucleolus ."
],
"offsets": [
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0,
109
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]
}
] |
[
{
"id": "split_0_train_44888_entity",
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"Cdc14"
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57,
62
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{
"id": "split_0_train_44889_entity",
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65,
69
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{
"id": "split_0_train_44890_entity",
"type": "progene_text",
"text": [
"Cdc14"
],
"offsets": [
[
85,
90
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27726
|
split_0_train_27726
|
[
{
"id": "split_0_train_27726_passage",
"type": "progene_text",
"text": [
"NS5A , a nonstructural protein of hepatitis C virus , binds growth factor receptor - bound protein 2 adaptor protein in a Src homology 3 domain / ligand - dependent manner and perturbs mitogenic signaling ."
],
"offsets": [
[
0,
206
]
]
}
] |
[
{
"id": "split_0_train_44891_entity",
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"text": [
"NS5A"
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[
0,
4
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},
{
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9,
30
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},
{
"id": "split_0_train_44893_entity",
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60,
100
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{
"id": "split_0_train_44894_entity",
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"adaptor protein"
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101,
116
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{
"id": "split_0_train_44895_entity",
"type": "progene_text",
"text": [
"Src"
],
"offsets": [
[
122,
125
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27727
|
split_0_train_27727
|
[
{
"id": "split_0_train_27727_passage",
"type": "progene_text",
"text": [
"Although hepatitis C virus ( HCV ) infection is an emerging global epidemic causing severe liver disorders , the molecular mechanisms of HCV pathogenesis remain elusive ."
],
"offsets": [
[
0,
170
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27728
|
split_0_train_27728
|
[
{
"id": "split_0_train_27728_passage",
"type": "progene_text",
"text": [
"The NS5A nonstructural protein of HCV contains several proline - rich sequences consistent with Src homology ( SH ) 3 - binding sites found in cellular signaling molecules ."
],
"offsets": [
[
0,
173
]
]
}
] |
[
{
"id": "split_0_train_44896_entity",
"type": "progene_text",
"text": [
"NS5A"
],
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[
4,
8
]
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},
{
"id": "split_0_train_44897_entity",
"type": "progene_text",
"text": [
"Src"
],
"offsets": [
[
96,
99
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27729
|
split_0_train_27729
|
[
{
"id": "split_0_train_27729_passage",
"type": "progene_text",
"text": [
"Here , we demonstrate that NS5A specifically bound to growth factor receptor - bound protein 2 ( Grb2 ) adaptor protein ."
],
"offsets": [
[
0,
121
]
]
}
] |
[
{
"id": "split_0_train_44898_entity",
"type": "progene_text",
"text": [
"NS5A"
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[
27,
31
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],
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},
{
"id": "split_0_train_44899_entity",
"type": "progene_text",
"text": [
"growth factor receptor - bound protein 2"
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[
54,
94
]
],
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},
{
"id": "split_0_train_44900_entity",
"type": "progene_text",
"text": [
"Grb2"
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[
97,
101
]
],
"normalized": []
},
{
"id": "split_0_train_44901_entity",
"type": "progene_text",
"text": [
"adaptor protein"
],
"offsets": [
[
104,
119
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27730
|
split_0_train_27730
|
[
{
"id": "split_0_train_27730_passage",
"type": "progene_text",
"text": [
"Immunoblot analysis of anti - Grb2 immune complexes derived from HeLa S3 cells infected with a recombinant vaccinia virus ( VV ) expressing NS5A revealed an interaction between NS5A and Grb2 in vivo ."
],
"offsets": [
[
0,
200
]
]
}
] |
[
{
"id": "split_0_train_44902_entity",
"type": "progene_text",
"text": [
"Grb2"
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[
30,
34
]
],
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},
{
"id": "split_0_train_44903_entity",
"type": "progene_text",
"text": [
"NS5A"
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[
140,
144
]
],
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},
{
"id": "split_0_train_44904_entity",
"type": "progene_text",
"text": [
"NS5A"
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[
177,
181
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],
"normalized": []
},
{
"id": "split_0_train_44905_entity",
"type": "progene_text",
"text": [
"Grb2"
],
"offsets": [
[
186,
190
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27731
|
split_0_train_27731
|
[
{
"id": "split_0_train_27731_passage",
"type": "progene_text",
"text": [
"An inactivating point mutation in the N - terminal SH3 domain , but not in the C - terminal SH3 domain , of Grb2 displayed significant diminished binding to NS5A ."
],
"offsets": [
[
0,
163
]
]
}
] |
[
{
"id": "split_0_train_44906_entity",
"type": "progene_text",
"text": [
"Grb2"
],
"offsets": [
[
108,
112
]
],
"normalized": []
},
{
"id": "split_0_train_44907_entity",
"type": "progene_text",
"text": [
"NS5A"
],
"offsets": [
[
157,
161
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27732
|
split_0_train_27732
|
[
{
"id": "split_0_train_27732_passage",
"type": "progene_text",
"text": [
"However , the same mutation in both SH3 regions completely abrogated Grb2 binding to NS5A , implying that the two SH3 domains bind in cooperative fashion to NS5A ."
],
"offsets": [
[
0,
163
]
]
}
] |
[
{
"id": "split_0_train_44908_entity",
"type": "progene_text",
"text": [
"Grb2"
],
"offsets": [
[
69,
73
]
],
"normalized": []
},
{
"id": "split_0_train_44909_entity",
"type": "progene_text",
"text": [
"NS5A"
],
"offsets": [
[
157,
161
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27733
|
split_0_train_27733
|
[
{
"id": "split_0_train_27733_passage",
"type": "progene_text",
"text": [
"Further , mutational analysis of NS5A assigned the SH3 - binding region to a proline - rich motif that is highly conserved among HCV genotypes ."
],
"offsets": [
[
0,
144
]
]
}
] |
[
{
"id": "split_0_train_44910_entity",
"type": "progene_text",
"text": [
"NS5A"
],
"offsets": [
[
33,
37
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27734
|
split_0_train_27734
|
[
{
"id": "split_0_train_27734_passage",
"type": "progene_text",
"text": [
"Importantly , phosphorylation of extracellular signal - regulated kinases 1 and 2 ( ERK1 / 2 ) was inhibited in HeLa S3 cells infected with NS5A - expressing recombinant VV but not recombinant VV control ."
],
"offsets": [
[
0,
205
]
]
}
] |
[
{
"id": "split_0_train_44911_entity",
"type": "progene_text",
"text": [
"extracellular signal - regulated kinases 1 and 2"
],
"offsets": [
[
33,
81
]
],
"normalized": []
},
{
"id": "split_0_train_44912_entity",
"type": "progene_text",
"text": [
"ERK1 / 2"
],
"offsets": [
[
84,
92
]
],
"normalized": []
},
{
"id": "split_0_train_44913_entity",
"type": "progene_text",
"text": [
"NS5A"
],
"offsets": [
[
140,
144
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27735
|
split_0_train_27735
|
[
{
"id": "split_0_train_27735_passage",
"type": "progene_text",
"text": [
"Additionally , HeLa cells stably expressing NS5A were refractory to ERK1 / 2 phosphorylation induced by exogenous epidermal growth factor ."
],
"offsets": [
[
0,
139
]
]
}
] |
[
{
"id": "split_0_train_44914_entity",
"type": "progene_text",
"text": [
"NS5A"
],
"offsets": [
[
44,
48
]
],
"normalized": []
},
{
"id": "split_0_train_44915_entity",
"type": "progene_text",
"text": [
"ERK1 / 2"
],
"offsets": [
[
68,
76
]
],
"normalized": []
},
{
"id": "split_0_train_44916_entity",
"type": "progene_text",
"text": [
"epidermal growth factor"
],
"offsets": [
[
114,
137
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27736
|
split_0_train_27736
|
[
{
"id": "split_0_train_27736_passage",
"type": "progene_text",
"text": [
"Moreover , the coupling of NS5A to Grb2 in these cells was induced by epidermal growth factor stimulation ."
],
"offsets": [
[
0,
107
]
]
}
] |
[
{
"id": "split_0_train_44917_entity",
"type": "progene_text",
"text": [
"NS5A"
],
"offsets": [
[
27,
31
]
],
"normalized": []
},
{
"id": "split_0_train_44918_entity",
"type": "progene_text",
"text": [
"Grb2"
],
"offsets": [
[
35,
39
]
],
"normalized": []
},
{
"id": "split_0_train_44919_entity",
"type": "progene_text",
"text": [
"epidermal growth factor"
],
"offsets": [
[
70,
93
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27737
|
split_0_train_27737
|
[
{
"id": "split_0_train_27737_passage",
"type": "progene_text",
"text": [
"Therefore , NS5A may function to perturb Grb2 - mediated signaling pathways by selectively targeting the adaptor ."
],
"offsets": [
[
0,
114
]
]
}
] |
[
{
"id": "split_0_train_44920_entity",
"type": "progene_text",
"text": [
"NS5A"
],
"offsets": [
[
12,
16
]
],
"normalized": []
},
{
"id": "split_0_train_44921_entity",
"type": "progene_text",
"text": [
"Grb2"
],
"offsets": [
[
41,
45
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27738
|
split_0_train_27738
|
[
{
"id": "split_0_train_27738_passage",
"type": "progene_text",
"text": [
"These findings highlight a viral interceptor of cellular signaling with potential implications for HCV pathogenesis ."
],
"offsets": [
[
0,
117
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27739
|
split_0_train_27739
|
[
{
"id": "split_0_train_27739_passage",
"type": "progene_text",
"text": [
"Xenopus Pax-2 / 5 / 8 orthologues : novel insights into Pax gene evolution and identification of Pax-8 as the earliest marker for otic and pronephric cell lineages ."
],
"offsets": [
[
0,
165
]
]
}
] |
[
{
"id": "split_0_train_44922_entity",
"type": "progene_text",
"text": [
"Pax-2 / 5 / 8"
],
"offsets": [
[
8,
21
]
],
"normalized": []
},
{
"id": "split_0_train_44923_entity",
"type": "progene_text",
"text": [
"Pax"
],
"offsets": [
[
56,
59
]
],
"normalized": []
},
{
"id": "split_0_train_44924_entity",
"type": "progene_text",
"text": [
"Pax-8"
],
"offsets": [
[
97,
102
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27740
|
split_0_train_27740
|
[
{
"id": "split_0_train_27740_passage",
"type": "progene_text",
"text": [
"Pax genes are a family of transcription factors playing fundamental roles during organogenesis ."
],
"offsets": [
[
0,
96
]
]
}
] |
[
{
"id": "split_0_train_44925_entity",
"type": "progene_text",
"text": [
"Pax"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_44926_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
26,
47
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27741
|
split_0_train_27741
|
[
{
"id": "split_0_train_27741_passage",
"type": "progene_text",
"text": [
"We have recently demonstrated the expression of Pax-2 during Xenopus embryogenesis [ Heller N , Br�¤ndli AW ( 1997 ) : Mech Dev 69 : 83-104 ] ."
],
"offsets": [
[
0,
145
]
]
}
] |
[
{
"id": "split_0_train_44927_entity",
"type": "progene_text",
"text": [
"Pax-2"
],
"offsets": [
[
48,
53
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27742
|
split_0_train_27742
|
[
{
"id": "split_0_train_27742_passage",
"type": "progene_text",
"text": [
"Here we report the cloning and characterization of Xenopus Pax-5 and Pax-8 , two orthologues of the Pax-2 / 5 / 8 gene family ."
],
"offsets": [
[
0,
127
]
]
}
] |
[
{
"id": "split_0_train_44928_entity",
"type": "progene_text",
"text": [
"Pax-5"
],
"offsets": [
[
59,
64
]
],
"normalized": []
},
{
"id": "split_0_train_44929_entity",
"type": "progene_text",
"text": [
"Pax-8"
],
"offsets": [
[
69,
74
]
],
"normalized": []
},
{
"id": "split_0_train_44930_entity",
"type": "progene_text",
"text": [
"Pax-2 / 5 / 8 gene family"
],
"offsets": [
[
100,
125
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27743
|
split_0_train_27743
|
[
{
"id": "split_0_train_27743_passage",
"type": "progene_text",
"text": [
"Molecular phylogenetic analysis indicates that the amphibian Pax-2 / 5 / 8 genes are close relatives of their mammalian counterparts and that all vertebrate Pax-2 / 5 / 8 genes are derived from a single ancestral gene ."
],
"offsets": [
[
0,
219
]
]
}
] |
[
{
"id": "split_0_train_44931_entity",
"type": "progene_text",
"text": [
"Pax-2 / 5 / 8"
],
"offsets": [
[
61,
74
]
],
"normalized": []
},
{
"id": "split_0_train_44932_entity",
"type": "progene_text",
"text": [
"Pax-2 / 5 / 8"
],
"offsets": [
[
157,
170
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27744
|
split_0_train_27744
|
[
{
"id": "split_0_train_27744_passage",
"type": "progene_text",
"text": [
"Xenopus Pax-2 / 5 / 8 genes are expressed in spatially and temporally overlapping patterns during development of at least seven distinct tissues ."
],
"offsets": [
[
0,
146
]
]
}
] |
[
{
"id": "split_0_train_44933_entity",
"type": "progene_text",
"text": [
"Pax-2 / 5 / 8"
],
"offsets": [
[
8,
21
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27745
|
split_0_train_27745
|
[
{
"id": "split_0_train_27745_passage",
"type": "progene_text",
"text": [
"Most strikingly , Xenopus Pax-8 was identified as the earliest marker of the prospective otic placode and of the intermediate mesoderm , indicating that Pax-8 may play a central role in auditory and excretory system development ."
],
"offsets": [
[
0,
229
]
]
}
] |
[
{
"id": "split_0_train_44934_entity",
"type": "progene_text",
"text": [
"Pax-8"
],
"offsets": [
[
26,
31
]
],
"normalized": []
},
{
"id": "split_0_train_44935_entity",
"type": "progene_text",
"text": [
"Pax-8"
],
"offsets": [
[
153,
158
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27746
|
split_0_train_27746
|
[
{
"id": "split_0_train_27746_passage",
"type": "progene_text",
"text": [
"Comparison of the expression patterns of fish , amphibian , and mammalian Pax-2 / 5 / 8 genes revealed that the tissue specificity of Pax-2 / 5 / 8 gene family expression is overall evolutionarily conserved ."
],
"offsets": [
[
0,
208
]
]
}
] |
[
{
"id": "split_0_train_44936_entity",
"type": "progene_text",
"text": [
"Pax-2 / 5 / 8"
],
"offsets": [
[
74,
87
]
],
"normalized": []
},
{
"id": "split_0_train_44937_entity",
"type": "progene_text",
"text": [
"Pax-2 / 5 / 8 gene family"
],
"offsets": [
[
134,
159
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27747
|
split_0_train_27747
|
[
{
"id": "split_0_train_27747_passage",
"type": "progene_text",
"text": [
"The expression domains of individual orthologues can however vary in a species - specific manner ."
],
"offsets": [
[
0,
98
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27748
|
split_0_train_27748
|
[
{
"id": "split_0_train_27748_passage",
"type": "progene_text",
"text": [
"For example , the thyroid glands of mammals express Pax-8 , while in Xenopus Pax-2 is expressed instead ."
],
"offsets": [
[
0,
105
]
]
}
] |
[
{
"id": "split_0_train_44938_entity",
"type": "progene_text",
"text": [
"Pax-8"
],
"offsets": [
[
52,
57
]
],
"normalized": []
},
{
"id": "split_0_train_44939_entity",
"type": "progene_text",
"text": [
"Pax-2"
],
"offsets": [
[
77,
82
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27749
|
split_0_train_27749
|
[
{
"id": "split_0_train_27749_passage",
"type": "progene_text",
"text": [
"Our findings indicate that differential silencing of Pax-2 / 5 / 8 gene expression may have occurred after the different classes of vertebrates began to evolve separately ."
],
"offsets": [
[
0,
172
]
]
}
] |
[
{
"id": "split_0_train_44940_entity",
"type": "progene_text",
"text": [
"Pax-2 / 5 / 8"
],
"offsets": [
[
53,
66
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27750
|
split_0_train_27750
|
[
{
"id": "split_0_train_27750_passage",
"type": "progene_text",
"text": [
"Vitamin D3 supplementation of beef steers increases longissimus tenderness ."
],
"offsets": [
[
0,
76
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27751
|
split_0_train_27751
|
[
{
"id": "split_0_train_27751_passage",
"type": "progene_text",
"text": [
"The objectives of these experiments were to determine 1) the effectiveness of supplemental vitamin D3 ( VITD ) on altering plasma and muscle calcium levels , 2 ) whether VITD supplementation improves Warner - Bratzler shear force ( WBS ) values of steaks from feedlot beef steers , and 3 ) the tenderness response curve of longissimus steaks from steers supplemented with VITD ."
],
"offsets": [
[
0,
378
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27752
|
split_0_train_27752
|
[
{
"id": "split_0_train_27752_passage",
"type": "progene_text",
"text": [
"In Exp. 1 , 20 crossbred steers were assigned randomly to one of four treatment diets consisting of either 0 , 2.5 , 5.0 , or 7.5 x 106 IU of VITD per day for 10 d ."
],
"offsets": [
[
0,
165
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27753
|
split_0_train_27753
|
[
{
"id": "split_0_train_27753_passage",
"type": "progene_text",
"text": [
"Blood samples were obtained daily during this supplementation period and 5 d thereafter ( d 11 to 15 ) ."
],
"offsets": [
[
0,
104
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27754
|
split_0_train_27754
|
[
{
"id": "split_0_train_27754_passage",
"type": "progene_text",
"text": [
"Between d 6 and 13 , a linear increase ( P < .01 ) in ionized plasma calcium concentrations was observed in steers supplemented with VITD ."
],
"offsets": [
[
0,
139
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27755
|
split_0_train_27755
|
[
{
"id": "split_0_train_27755_passage",
"type": "progene_text",
"text": [
"Compared to unsupplemented steers , serum calcium concentrations of the steers receiving 7.5 x 106 IU of VITD per day were increased 8 to 48 % ."
],
"offsets": [
[
0,
144
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27756
|
split_0_train_27756
|
[
{
"id": "split_0_train_27756_passage",
"type": "progene_text",
"text": [
"In Exp. 2 , longissimus samples from crossbred steers ( n = 118 ) that were supplemented with either 0 or 5 x 106 IU of VITD per day for 7 d were obtained and aged for 7 , 14 , or 21 d ."
],
"offsets": [
[
0,
186
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27757
|
split_0_train_27757
|
[
{
"id": "split_0_train_27757_passage",
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"text": [
"Following the initial 7-d postmortem aging period , VITD supplementation lowered ( P < .01 ) WBS ( .58 kg ) and increased sensory tenderness rating ( .6 units ) compared to cuts originating from unsupplemented steers ."
],
"offsets": [
[
0,
218
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27758
|
split_0_train_27758
|
[
{
"id": "split_0_train_27758_passage",
"type": "progene_text",
"text": [
"In Exp. 3 , 44 steers were supplemented with either 0 or 7.5 x 106 IU of VITD per day for 10 d immediately prior to slaughter ."
],
"offsets": [
[
0,
127
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27759
|
split_0_train_27759
|
[
{
"id": "split_0_train_27759_passage",
"type": "progene_text",
"text": [
"Results indicated that plasma and longissimus calcium concentration were higher ( P < .05 ) for steers that received supplemental VITD ."
],
"offsets": [
[
0,
136
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27760
|
split_0_train_27760
|
[
{
"id": "split_0_train_27760_passage",
"type": "progene_text",
"text": [
"Compared with unsupplemented cuts , VITD supplementation improved WBS of cuts aged for either 7 or 14 d ( P = .02 and P = .07 , respectively ) ."
],
"offsets": [
[
0,
144
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27761
|
split_0_train_27761
|
[
{
"id": "split_0_train_27761_passage",
"type": "progene_text",
"text": [
"Sensory panelists rated samples from VITD supplemented steers as more tender than their unsupplemented counterparts ."
],
"offsets": [
[
0,
117
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27762
|
split_0_train_27762
|
[
{
"id": "split_0_train_27762_passage",
"type": "progene_text",
"text": [
"Activation of calpain proteases could be responsible for the observed tenderization due to the supplementation of VITD ."
],
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[
0,
120
]
]
}
] |
[
{
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"text": [
"calpain proteases"
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[
14,
31
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27763
|
split_0_train_27763
|
[
{
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"type": "progene_text",
"text": [
"Cell cycle regulation of DNA replication initiator factor Dbf4p ."
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0,
65
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]
}
] |
[
{
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29,
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{
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"text": [
"Dbf4p"
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58,
63
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27764
|
split_0_train_27764
|
[
{
"id": "split_0_train_27764_passage",
"type": "progene_text",
"text": [
"The precise duplication of eukaryotic genetic material takes place once and only once per cell cycle and is dependent on the completion of the previous mitosis ."
],
"offsets": [
[
0,
161
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27765
|
split_0_train_27765
|
[
{
"id": "split_0_train_27765_passage",
"type": "progene_text",
"text": [
"Two evolutionarily conserved kinases , the cyclin B ( Clb ) / cyclin - dependent kinase ( Cdk / Cdc28p ) and Cdc7p along with its interacting factor Dbf4p , are required late in G1 to initiate DNA replication ."
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[
0,
210
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]
}
] |
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{
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96,
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{
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109,
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{
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"text": [
"Dbf4p"
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[
149,
154
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27766
|
split_0_train_27766
|
[
{
"id": "split_0_train_27766_passage",
"type": "progene_text",
"text": [
"We have determined that the levels of Dbf4p are cell cycle regulated ."
],
"offsets": [
[
0,
70
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]
}
] |
[
{
"id": "split_0_train_44952_entity",
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"text": [
"Dbf4p"
],
"offsets": [
[
38,
43
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27767
|
split_0_train_27767
|
[
{
"id": "split_0_train_27767_passage",
"type": "progene_text",
"text": [
"Dbf4p levels increase as cells begin S phase and remain high through late mitosis , after which they decline dramatically as cells begin the next cell cycle ."
],
"offsets": [
[
0,
158
]
]
}
] |
[
{
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"type": "progene_text",
"text": [
"Dbf4p"
],
"offsets": [
[
0,
5
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27768
|
split_0_train_27768
|
[
{
"id": "split_0_train_27768_passage",
"type": "progene_text",
"text": [
"We report that Dbf4p levels are sensitive to mutations in key components of the anaphase - promoting complex ( APC ) ."
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[
0,
118
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]
}
] |
[
{
"id": "split_0_train_44954_entity",
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15,
20
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{
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"text": [
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80,
108
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{
"id": "split_0_train_44956_entity",
"type": "progene_text",
"text": [
"APC"
],
"offsets": [
[
111,
114
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27769
|
split_0_train_27769
|
[
{
"id": "split_0_train_27769_passage",
"type": "progene_text",
"text": [
"In addition , Dbf4p is modified in response to DNA damage , and this modification is dependent upon the DNA damage response pathway ."
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "split_0_train_44957_entity",
"type": "progene_text",
"text": [
"Dbf4p"
],
"offsets": [
[
14,
19
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27770
|
split_0_train_27770
|
[
{
"id": "split_0_train_27770_passage",
"type": "progene_text",
"text": [
"We had previously shown that Dbf4p interacts with the M phase polo - like kinase Cdc5p , a key regulator of the APC late in mitosis ."
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "split_0_train_44958_entity",
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29,
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{
"id": "split_0_train_44959_entity",
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62,
80
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{
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"type": "progene_text",
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"Cdc5p"
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81,
86
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},
{
"id": "split_0_train_44961_entity",
"type": "progene_text",
"text": [
"APC"
],
"offsets": [
[
112,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27771
|
split_0_train_27771
|
[
{
"id": "split_0_train_27771_passage",
"type": "progene_text",
"text": [
"These results further link the actions of the initiator protein , Dbf4p , to the completion of mitosis and suggest possible roles for Dbf4p during progression through mitosis ."
],
"offsets": [
[
0,
176
]
]
}
] |
[
{
"id": "split_0_train_44962_entity",
"type": "progene_text",
"text": [
"Dbf4p"
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[
66,
71
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},
{
"id": "split_0_train_44963_entity",
"type": "progene_text",
"text": [
"Dbf4p"
],
"offsets": [
[
134,
139
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27772
|
split_0_train_27772
|
[
{
"id": "split_0_train_27772_passage",
"type": "progene_text",
"text": [
"Enhancer function and novel DNA binding protein activity in the near upstream betaAPP gene promoter ."
],
"offsets": [
[
0,
101
]
]
}
] |
[
{
"id": "split_0_train_44964_entity",
"type": "progene_text",
"text": [
"betaAPP"
],
"offsets": [
[
78,
85
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27773
|
split_0_train_27773
|
[
{
"id": "split_0_train_27773_passage",
"type": "progene_text",
"text": [
"The role of betaAPP gene transcription and promoter regulation in modifying amyloid beta-peptide ( Abeta ) levels is not well understood ."
],
"offsets": [
[
0,
138
]
]
}
] |
[
{
"id": "split_0_train_44965_entity",
"type": "progene_text",
"text": [
"betaAPP"
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12,
19
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},
{
"id": "split_0_train_44966_entity",
"type": "progene_text",
"text": [
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76,
96
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{
"id": "split_0_train_44967_entity",
"type": "progene_text",
"text": [
"Abeta"
],
"offsets": [
[
99,
104
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27774
|
split_0_train_27774
|
[
{
"id": "split_0_train_27774_passage",
"type": "progene_text",
"text": [
"Increased production of Abeta or changes in Abeta42 / Abeta40 ratio by fibroblasts occurs in the presence of mutant presenilin or betaAPP alleles in familial Alzheimer 's disease subjects ."
],
"offsets": [
[
0,
189
]
]
}
] |
[
{
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"type": "progene_text",
"text": [
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24,
29
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{
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"type": "progene_text",
"text": [
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44,
51
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},
{
"id": "split_0_train_44970_entity",
"type": "progene_text",
"text": [
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54,
61
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},
{
"id": "split_0_train_44971_entity",
"type": "progene_text",
"text": [
"presenilin"
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116,
126
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},
{
"id": "split_0_train_44972_entity",
"type": "progene_text",
"text": [
"betaAPP"
],
"offsets": [
[
130,
137
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27775
|
split_0_train_27775
|
[
{
"id": "split_0_train_27775_passage",
"type": "progene_text",
"text": [
"Both betaAPP mRNA and Abeta levels are increased in trisomy 21 ."
],
"offsets": [
[
0,
64
]
]
}
] |
[
{
"id": "split_0_train_44973_entity",
"type": "progene_text",
"text": [
"betaAPP"
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5,
12
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},
{
"id": "split_0_train_44974_entity",
"type": "progene_text",
"text": [
"Abeta"
],
"offsets": [
[
22,
27
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27776
|
split_0_train_27776
|
[
{
"id": "split_0_train_27776_passage",
"type": "progene_text",
"text": [
"The APP gene promoter is in a class of housekeeping genes and contains two putative consensus sites for the binding of transcription factor AP1 ."
],
"offsets": [
[
0,
145
]
]
}
] |
[
{
"id": "split_0_train_44975_entity",
"type": "progene_text",
"text": [
"APP"
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"offsets": [
[
4,
7
]
],
"normalized": []
},
{
"id": "split_0_train_44976_entity",
"type": "progene_text",
"text": [
"transcription factor"
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"offsets": [
[
119,
139
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],
"normalized": []
},
{
"id": "split_0_train_44977_entity",
"type": "progene_text",
"text": [
"AP1"
],
"offsets": [
[
140,
143
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27777
|
split_0_train_27777
|
[
{
"id": "split_0_train_27777_passage",
"type": "progene_text",
"text": [
"Electrophoretic mobility shift ( EMSA ) and DNase protection assays using human fibroblast and HeLa nuclear extract identified specific protein binding with novel Sp1 - like properties to both a near - upstream and a downstream domain of the betaAPP promoter ."
],
"offsets": [
[
0,
260
]
]
}
] |
[
{
"id": "split_0_train_44978_entity",
"type": "progene_text",
"text": [
"DNase"
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[
44,
49
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],
"normalized": []
},
{
"id": "split_0_train_44979_entity",
"type": "progene_text",
"text": [
"Sp1"
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[
163,
166
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"normalized": []
},
{
"id": "split_0_train_44980_entity",
"type": "progene_text",
"text": [
"betaAPP"
],
"offsets": [
[
242,
249
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27778
|
split_0_train_27778
|
[
{
"id": "split_0_train_27778_passage",
"type": "progene_text",
"text": [
"The upstream binding activity was localized to a putative AP1 consensus site and its immediate 5'-adjacent GC - rich element ."
],
"offsets": [
[
0,
126
]
]
}
] |
[
{
"id": "split_0_train_44981_entity",
"type": "progene_text",
"text": [
"AP1"
],
"offsets": [
[
58,
61
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27779
|
split_0_train_27779
|
[
{
"id": "split_0_train_27779_passage",
"type": "progene_text",
"text": [
"However , c-Jun antibody and competition experiments had no effect on binding to this domain ."
],
"offsets": [
[
0,
94
]
]
}
] |
[
{
"id": "split_0_train_44982_entity",
"type": "progene_text",
"text": [
"c-Jun"
],
"offsets": [
[
10,
15
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27780
|
split_0_train_27780
|
[
{
"id": "split_0_train_27780_passage",
"type": "progene_text",
"text": [
"A series of 5' - deleted betaAPP promoter - reporter gene transfections in HeLa and fibroblast cells showed that the domain - containing region , n.t. - 383 to - 348 , exerts a 2.9 - fold activating influence on basal pbetaAPP - reporter transcription ."
],
"offsets": [
[
0,
253
]
]
}
] |
[
{
"id": "split_0_train_44983_entity",
"type": "progene_text",
"text": [
"betaAPP"
],
"offsets": [
[
25,
32
]
],
"normalized": []
},
{
"id": "split_0_train_44984_entity",
"type": "progene_text",
"text": [
"pbetaAPP"
],
"offsets": [
[
218,
226
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27781
|
split_0_train_27781
|
[
{
"id": "split_0_train_27781_passage",
"type": "progene_text",
"text": [
"When subcloned to test enhancer function , the 5'-GC element / ' AP1 site ' tandem construct conferred four - fold greater activity than either element alone and two - fold greater than the more 3'-situated HSE consensus sequence ."
],
"offsets": [
[
0,
231
]
]
}
] |
[
{
"id": "split_0_train_44985_entity",
"type": "progene_text",
"text": [
"AP1"
],
"offsets": [
[
65,
68
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27782
|
split_0_train_27782
|
[
{
"id": "split_0_train_27782_passage",
"type": "progene_text",
"text": [
"Phorbol ester treatment had no effect in these reporter assays ."
],
"offsets": [
[
0,
64
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27783
|
split_0_train_27783
|
[
{
"id": "split_0_train_27783_passage",
"type": "progene_text",
"text": [
"This element shares homology and binding properties with a domain immediately 5' to the downstream E-box / USF element ."
],
"offsets": [
[
0,
120
]
]
}
] |
[
{
"id": "split_0_train_44986_entity",
"type": "progene_text",
"text": [
"USF"
],
"offsets": [
[
107,
110
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27784
|
split_0_train_27784
|
[
{
"id": "split_0_train_27784_passage",
"type": "progene_text",
"text": [
"An interaction model involving both domains and looping of interjacent DNA is proposed ."
],
"offsets": [
[
0,
88
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27785
|
split_0_train_27785
|
[
{
"id": "split_0_train_27785_passage",
"type": "progene_text",
"text": [
"We conclude that this newly described binding protein - enhancer complex is required for full betaAPP promoter activation ."
],
"offsets": [
[
0,
123
]
]
}
] |
[
{
"id": "split_0_train_44987_entity",
"type": "progene_text",
"text": [
"betaAPP"
],
"offsets": [
[
94,
101
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27786
|
split_0_train_27786
|
[
{
"id": "split_0_train_27786_passage",
"type": "progene_text",
"text": [
"Characterization of human , Schizosaccharomyces pombe , and Candida albicans mRNA cap methyltransferases and complete replacement of the yeast capping apparatus by mammalian enzymes ."
],
"offsets": [
[
0,
183
]
]
}
] |
[
{
"id": "split_0_train_44988_entity",
"type": "progene_text",
"text": [
"mRNA cap methyltransferases"
],
"offsets": [
[
77,
104
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27787
|
split_0_train_27787
|
[
{
"id": "split_0_train_27787_passage",
"type": "progene_text",
"text": [
"Human and fission yeast cDNAs encoding mRNA ( guanine - N7 ) methyltransferase were identified based on similarity of the human ( Hcm1p ; 476 amino acids ) and Schizosaccharomyces pombe ( Pcm1p ; 389 amino acids ) polypeptides to the cap methyltransferase of Saccharomyces cerevisiae ( Abd1p ) ."
],
"offsets": [
[
0,
295
]
]
}
] |
[
{
"id": "split_0_train_44989_entity",
"type": "progene_text",
"text": [
"mRNA ( guanine - N7 ) methyltransferase"
],
"offsets": [
[
39,
78
]
],
"normalized": []
},
{
"id": "split_0_train_44990_entity",
"type": "progene_text",
"text": [
"Hcm1p"
],
"offsets": [
[
130,
135
]
],
"normalized": []
},
{
"id": "split_0_train_44991_entity",
"type": "progene_text",
"text": [
"Pcm1p"
],
"offsets": [
[
188,
193
]
],
"normalized": []
},
{
"id": "split_0_train_44992_entity",
"type": "progene_text",
"text": [
"cap methyltransferase"
],
"offsets": [
[
234,
255
]
],
"normalized": []
},
{
"id": "split_0_train_44993_entity",
"type": "progene_text",
"text": [
"Abd1p"
],
"offsets": [
[
286,
291
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27788
|
split_0_train_27788
|
[
{
"id": "split_0_train_27788_passage",
"type": "progene_text",
"text": [
"Expression of PCM1 or HCM1 in S. cerevisiae complemented the lethal phenotype resulting from deletion of the ABD1 gene , as did expression of the NH2 - terminal deletion mutants PCM1 (94-389 ) and HCM1 ( 121 - 476 ) ."
],
"offsets": [
[
0,
217
]
]
}
] |
[
{
"id": "split_0_train_44994_entity",
"type": "progene_text",
"text": [
"PCM1"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "split_0_train_44995_entity",
"type": "progene_text",
"text": [
"HCM1"
],
"offsets": [
[
22,
26
]
],
"normalized": []
},
{
"id": "split_0_train_44996_entity",
"type": "progene_text",
"text": [
"ABD1"
],
"offsets": [
[
109,
113
]
],
"normalized": []
},
{
"id": "split_0_train_44997_entity",
"type": "progene_text",
"text": [
"PCM1"
],
"offsets": [
[
178,
182
]
],
"normalized": []
},
{
"id": "split_0_train_44998_entity",
"type": "progene_text",
"text": [
"HCM1"
],
"offsets": [
[
197,
201
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27789
|
split_0_train_27789
|
[
{
"id": "split_0_train_27789_passage",
"type": "progene_text",
"text": [
"The CCM1 gene encoding Candida albicans cap methyltransferase ( Ccm1p ; 474 amino acids ) was isolated from a C. albicans genomic library by selection for complementation of the conditional growth phenotype of S. cerevisiae abd1 - ts mutants ."
],
"offsets": [
[
0,
243
]
]
}
] |
[
{
"id": "split_0_train_44999_entity",
"type": "progene_text",
"text": [
"CCM1"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_45000_entity",
"type": "progene_text",
"text": [
"cap methyltransferase"
],
"offsets": [
[
40,
61
]
],
"normalized": []
},
{
"id": "split_0_train_45001_entity",
"type": "progene_text",
"text": [
"Ccm1p"
],
"offsets": [
[
64,
69
]
],
"normalized": []
},
{
"id": "split_0_train_45002_entity",
"type": "progene_text",
"text": [
"abd1"
],
"offsets": [
[
224,
228
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27790
|
split_0_train_27790
|
[
{
"id": "split_0_train_27790_passage",
"type": "progene_text",
"text": [
"Human cap methyltransferase was expressed in bacteria , purified , and characterized ."
],
"offsets": [
[
0,
86
]
]
}
] |
[
{
"id": "split_0_train_45003_entity",
"type": "progene_text",
"text": [
"cap methyltransferase"
],
"offsets": [
[
6,
27
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27791
|
split_0_train_27791
|
[
{
"id": "split_0_train_27791_passage",
"type": "progene_text",
"text": [
"Recombinant Hcm1p catalyzed quantitative S-adenosylmethionine - dependent conversion of GpppA-capped poly(A) to m7GpppA - capped poly(A) ."
],
"offsets": [
[
0,
138
]
]
}
] |
[
{
"id": "split_0_train_45004_entity",
"type": "progene_text",
"text": [
"Hcm1p"
],
"offsets": [
[
12,
17
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27792
|
split_0_train_27792
|
[
{
"id": "split_0_train_27792_passage",
"type": "progene_text",
"text": [
"We identified by alanine - scanning mutagenesis eight amino acids ( Asp - 203 , Gly - 207 , Asp - 211 , Asp - 227 , Arg - 239 , Tyr - 289 , Phe - 291 , and Phe-354 ) that are essential for human cap methyltransferase function in vivo ."
],
"offsets": [
[
0,
235
]
]
}
] |
[
{
"id": "split_0_train_45005_entity",
"type": "progene_text",
"text": [
"cap methyltransferase"
],
"offsets": [
[
195,
216
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27793
|
split_0_train_27793
|
[
{
"id": "split_0_train_27793_passage",
"type": "progene_text",
"text": [
"All eight residues are conserved in other cellular cap methyltransferases ."
],
"offsets": [
[
0,
75
]
]
}
] |
[
{
"id": "split_0_train_45006_entity",
"type": "progene_text",
"text": [
"cap methyltransferases"
],
"offsets": [
[
51,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27794
|
split_0_train_27794
|
[
{
"id": "split_0_train_27794_passage",
"type": "progene_text",
"text": [
"Five of the mutant human proteins ( D203A , R239A , Y289A , F291A , and F354A ) were expressed in bacteria and found to be defective in cap methylation in vitro ."
],
"offsets": [
[
0,
162
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27795
|
split_0_train_27795
|
[
{
"id": "split_0_train_27795_passage",
"type": "progene_text",
"text": [
"Concordance of mutational effects on Hcm1p , Abd1p , and vaccinia capping enzyme underscores a conserved structural basis for cap methylation in DNA viruses , yeast , and metazoans ."
],
"offsets": [
[
0,
182
]
]
}
] |
[
{
"id": "split_0_train_45007_entity",
"type": "progene_text",
"text": [
"Hcm1p"
],
"offsets": [
[
37,
42
]
],
"normalized": []
},
{
"id": "split_0_train_45008_entity",
"type": "progene_text",
"text": [
"Abd1p"
],
"offsets": [
[
45,
50
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27796
|
split_0_train_27796
|
[
{
"id": "split_0_train_27796_passage",
"type": "progene_text",
"text": [
"This is in contrast to the structural and mechanistic divergence of the RNA triphosphatase components of the yeast and metazoan capping systems ."
],
"offsets": [
[
0,
145
]
]
}
] |
[
{
"id": "split_0_train_45009_entity",
"type": "progene_text",
"text": [
"RNA triphosphatase"
],
"offsets": [
[
72,
90
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27797
|
split_0_train_27797
|
[
{
"id": "split_0_train_27797_passage",
"type": "progene_text",
"text": [
"Nevertheless , we demonstrate that the entire three - component yeast capping apparatus , consisting of RNA 5'-triphosphatase ( Cet1p ) , RNA guanylyltransferase ( Ceg1p ) , and Abd1p could be replaced in vivo by the two - component mammalian apparatus consisting of a bifunctional triphosphatase - guanylyltransferase Mce1p and the methyltransferase Hcm1 (121-476 ) p ."
],
"offsets": [
[
0,
370
]
]
}
] |
[
{
"id": "split_0_train_45010_entity",
"type": "progene_text",
"text": [
"RNA 5'-triphosphatase"
],
"offsets": [
[
104,
125
]
],
"normalized": []
},
{
"id": "split_0_train_45011_entity",
"type": "progene_text",
"text": [
"Cet1p"
],
"offsets": [
[
128,
133
]
],
"normalized": []
},
{
"id": "split_0_train_45012_entity",
"type": "progene_text",
"text": [
"RNA guanylyltransferase"
],
"offsets": [
[
138,
161
]
],
"normalized": []
},
{
"id": "split_0_train_45013_entity",
"type": "progene_text",
"text": [
"Ceg1p"
],
"offsets": [
[
164,
169
]
],
"normalized": []
},
{
"id": "split_0_train_45014_entity",
"type": "progene_text",
"text": [
"Abd1p"
],
"offsets": [
[
178,
183
]
],
"normalized": []
},
{
"id": "split_0_train_45015_entity",
"type": "progene_text",
"text": [
"triphosphatase - guanylyltransferase Mce1p"
],
"offsets": [
[
282,
324
]
],
"normalized": []
},
{
"id": "split_0_train_45016_entity",
"type": "progene_text",
"text": [
"methyltransferase"
],
"offsets": [
[
333,
350
]
],
"normalized": []
},
{
"id": "split_0_train_45017_entity",
"type": "progene_text",
"text": [
"Hcm1"
],
"offsets": [
[
351,
355
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27798
|
split_0_train_27798
|
[
{
"id": "split_0_train_27798_passage",
"type": "progene_text",
"text": [
"Isogenic yeast strains with fungal versus mammalian capping systems should facilitate rational screens for antifungal drugs that target cap formation in vivo ."
],
"offsets": [
[
0,
159
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27799
|
split_0_train_27799
|
[
{
"id": "split_0_train_27799_passage",
"type": "progene_text",
"text": [
"[ Prognostic importance of preclinically evaluated biochemical mediators in polytrauma ]"
],
"offsets": [
[
0,
88
]
]
}
] |
[] |
[] |
[] |
[] |
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