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stringlengths 15
19
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stringlengths 15
19
| passages
list | entities
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list | relations
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|---|---|---|---|---|---|---|
split_0_train_27800
|
split_0_train_27800
|
[
{
"id": "split_0_train_27800_passage",
"type": "progene_text",
"text": [
"There is compelling data from several clinical studies on the impact of various anti - and proinflammatory mediators on traumatized patients ."
],
"offsets": [
[
0,
142
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27801
|
split_0_train_27801
|
[
{
"id": "split_0_train_27801_passage",
"type": "progene_text",
"text": [
"Immediate trauma - related results , however , are only available from animal experiments so far ."
],
"offsets": [
[
0,
98
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27802
|
split_0_train_27802
|
[
{
"id": "split_0_train_27802_passage",
"type": "progene_text",
"text": [
"Therefore , in this prospective clinical study the following questions were addressed : (I) Is there any marker in the preclinical phase that give information independent of and better than conventional studies conducted so far , ( II ) does this possible factor prove to be a ( significant ) predictor of late complications and/or poor overall outcome , and ( III ) does this mediator provide information that can alter treatment decisions ?"
],
"offsets": [
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0,
442
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}
] |
[] |
[] |
[] |
[] |
split_0_train_27803
|
split_0_train_27803
|
[
{
"id": "split_0_train_27803_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27804
|
split_0_train_27804
|
[
{
"id": "split_0_train_27804_passage",
"type": "progene_text",
"text": [
"Upon approval of the local IRB / IEC , 85 patients ( pts ) were enrolled who suffered from multiple injuries ."
],
"offsets": [
[
0,
110
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27805
|
split_0_train_27805
|
[
{
"id": "split_0_train_27805_passage",
"type": "progene_text",
"text": [
"The pts were rescued by the helicopter - based service of the German Army Hospital in Ulm ."
],
"offsets": [
[
0,
91
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27806
|
split_0_train_27806
|
[
{
"id": "split_0_train_27806_passage",
"type": "progene_text",
"text": [
"The first blood samples were drawn at the site of accident and at admission , then in hourly to daily intervals ."
],
"offsets": [
[
0,
113
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27807
|
split_0_train_27807
|
[
{
"id": "split_0_train_27807_passage",
"type": "progene_text",
"text": [
"The plasma concentrations of following mediators were analyzed :"
],
"offsets": [
[
0,
64
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27808
|
split_0_train_27808
|
[
{
"id": "split_0_train_27808_passage",
"type": "progene_text",
"text": [
"Prostanoids , products of O2 - radicals , soluble adhesion molecules , various cytokines , C - reactive protein , creatinine kinase , and neopterin ."
],
"offsets": [
[
0,
149
]
]
}
] |
[
{
"id": "split_0_train_45018_entity",
"type": "progene_text",
"text": [
"adhesion molecules"
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50,
68
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{
"id": "split_0_train_45019_entity",
"type": "progene_text",
"text": [
"cytokines"
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79,
88
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{
"id": "split_0_train_45020_entity",
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"text": [
"C - reactive protein"
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91,
111
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{
"id": "split_0_train_45021_entity",
"type": "progene_text",
"text": [
"creatinine kinase"
],
"offsets": [
[
114,
131
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27809
|
split_0_train_27809
|
[
{
"id": "split_0_train_27809_passage",
"type": "progene_text",
"text": [
"All values were calculated in relation to the actual plasma protein content to eliminate fluid - induced dilution effects ."
],
"offsets": [
[
0,
123
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27810
|
split_0_train_27810
|
[
{
"id": "split_0_train_27810_passage",
"type": "progene_text",
"text": [
"Subsets of patients were performed according to the severity of trauma ( ISS < 9 ; 9-17 ; 18-31 ; > 32 ) , based on the different injury pattern , and survivors versus nonsurvivors as well ."
],
"offsets": [
[
0,
190
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27811
|
split_0_train_27811
|
[
{
"id": "split_0_train_27811_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27812
|
split_0_train_27812
|
[
{
"id": "split_0_train_27812_passage",
"type": "progene_text",
"text": [
"As early as at the scene of accident , all patients revealed a severity - dependent increase in most mediators ' plasma levels ."
],
"offsets": [
[
0,
128
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27813
|
split_0_train_27813
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[
{
"id": "split_0_train_27813_passage",
"type": "progene_text",
"text": [
"There was , however , also a pattern - related inflammatory response that was most pronounced in pts who had suffered from thoracic trauma irrespective of whether it was associated with multiple trauma ."
],
"offsets": [
[
0,
203
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27814
|
split_0_train_27814
|
[
{
"id": "split_0_train_27814_passage",
"type": "progene_text",
"text": [
"In a total , 15 pts died within 72 h after the accident ."
],
"offsets": [
[
0,
57
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27815
|
split_0_train_27815
|
[
{
"id": "split_0_train_27815_passage",
"type": "progene_text",
"text": [
"In those casualties , the plasma concentrations of prostaglandin E2 ( P < 0.03 ) , glutathione ( P < 0.01 ) as well as creatinine kinase ( P < 0.05 ) were more markedly elevated when compared with survivors ."
],
"offsets": [
[
0,
208
]
]
}
] |
[
{
"id": "split_0_train_45022_entity",
"type": "progene_text",
"text": [
"creatinine kinase"
],
"offsets": [
[
119,
136
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27816
|
split_0_train_27816
|
[
{
"id": "split_0_train_27816_passage",
"type": "progene_text",
"text": [
"CONCLUSION :"
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27817
|
split_0_train_27817
|
[
{
"id": "split_0_train_27817_passage",
"type": "progene_text",
"text": [
"Although there were severity - dependent as well as pattern - related releases of various mediators , which in part were more apparent in nonsurviving patients , we failed in proving any predictive marker to specifically discriminate outcome ."
],
"offsets": [
[
0,
243
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27818
|
split_0_train_27818
|
[
{
"id": "split_0_train_27818_passage",
"type": "progene_text",
"text": [
"Fra-2 - positive autoregulatory loop triggered by mitogen - activated protein kinase ( MAPK ) and Fra-2 phosphorylation sites by MAPK ."
],
"offsets": [
[
0,
135
]
]
}
] |
[
{
"id": "split_0_train_45023_entity",
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"text": [
"Fra-2"
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0,
5
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{
"id": "split_0_train_45024_entity",
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"mitogen - activated protein kinase"
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50,
84
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{
"id": "split_0_train_45025_entity",
"type": "progene_text",
"text": [
"MAPK"
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87,
91
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{
"id": "split_0_train_45026_entity",
"type": "progene_text",
"text": [
"Fra-2"
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98,
103
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{
"id": "split_0_train_45027_entity",
"type": "progene_text",
"text": [
"MAPK"
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"offsets": [
[
129,
133
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27819
|
split_0_train_27819
|
[
{
"id": "split_0_train_27819_passage",
"type": "progene_text",
"text": [
"We reported previously that activation of endogenous activator protein 1 ( AP-1 ) in chicken embryo fibroblasts is essential for the cellular transformation induced by v-src , and we further showed that the activation of AP-1 is accompanied by elevation of Fra-2 and c-Jun expression and also high - level phosphorylation of Fra-2 by activated endogenous extracellular signal - regulated kinase [ mitogen - activated protein kinase ( MAPK ) ] ."
],
"offsets": [
[
0,
444
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]
}
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{
"id": "split_0_train_45028_entity",
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"activator protein 1"
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53,
72
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{
"id": "split_0_train_45029_entity",
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"AP-1"
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75,
79
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{
"id": "split_0_train_45030_entity",
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"text": [
"v-src"
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168,
173
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{
"id": "split_0_train_45031_entity",
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"text": [
"AP-1"
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221,
225
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{
"id": "split_0_train_45032_entity",
"type": "progene_text",
"text": [
"Fra-2"
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257,
262
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{
"id": "split_0_train_45033_entity",
"type": "progene_text",
"text": [
"c-Jun"
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267,
272
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{
"id": "split_0_train_45034_entity",
"type": "progene_text",
"text": [
"Fra-2"
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325,
330
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},
{
"id": "split_0_train_45035_entity",
"type": "progene_text",
"text": [
"extracellular signal - regulated kinase"
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355,
394
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{
"id": "split_0_train_45036_entity",
"type": "progene_text",
"text": [
"mitogen - activated protein kinase"
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397,
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{
"id": "split_0_train_45037_entity",
"type": "progene_text",
"text": [
"MAPK"
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"offsets": [
[
434,
438
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27820
|
split_0_train_27820
|
[
{
"id": "split_0_train_27820_passage",
"type": "progene_text",
"text": [
"Here , we report that the transcriptional activity of Fra-2 / c-Jun heterodimer was greatly enhanced by cotransfecting a constitutively active mutant of MEK1 gene ( MEK - DD ) into F9 cells , indicating that Fra-2 was converted into an active transactivator after phosphorylation by MAPK ."
],
"offsets": [
[
0,
289
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]
}
] |
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{
"id": "split_0_train_45038_entity",
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"text": [
"Fra-2"
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54,
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{
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"text": [
"c-Jun"
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62,
67
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{
"id": "split_0_train_45040_entity",
"type": "progene_text",
"text": [
"MEK1"
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153,
157
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{
"id": "split_0_train_45041_entity",
"type": "progene_text",
"text": [
"MEK"
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165,
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{
"id": "split_0_train_45042_entity",
"type": "progene_text",
"text": [
"Fra-2"
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"offsets": [
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208,
213
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{
"id": "split_0_train_45043_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
283,
287
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27821
|
split_0_train_27821
|
[
{
"id": "split_0_train_27821_passage",
"type": "progene_text",
"text": [
"High - level expression of MEK - DD alone was sufficient to induce clear cellular transformation of chicken embryo fibroblasts , which caused constitutive activation of endogenous MAPK , hyperphosphorylation of Fra-2 , and elevation of fra-2 and c-jun gene expression ."
],
"offsets": [
[
0,
269
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]
}
] |
[
{
"id": "split_0_train_45044_entity",
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"MEK"
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27,
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{
"id": "split_0_train_45045_entity",
"type": "progene_text",
"text": [
"MAPK"
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180,
184
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{
"id": "split_0_train_45046_entity",
"type": "progene_text",
"text": [
"Fra-2"
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"offsets": [
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211,
216
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],
"normalized": []
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{
"id": "split_0_train_45047_entity",
"type": "progene_text",
"text": [
"fra-2"
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"offsets": [
[
236,
241
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],
"normalized": []
},
{
"id": "split_0_train_45048_entity",
"type": "progene_text",
"text": [
"c-jun"
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"offsets": [
[
246,
251
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27822
|
split_0_train_27822
|
[
{
"id": "split_0_train_27822_passage",
"type": "progene_text",
"text": [
"These results indicate that phosphorylation of Fra-2 by MAPK plays an important role in stimulating endogenous AP-1 activity in a positive autoregulation mechanism , in which phosphorylated Fra-2 induces fra-2 expression through AP-1 binding sites present in its promoter ."
],
"offsets": [
[
0,
273
]
]
}
] |
[
{
"id": "split_0_train_45049_entity",
"type": "progene_text",
"text": [
"Fra-2"
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"offsets": [
[
47,
52
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],
"normalized": []
},
{
"id": "split_0_train_45050_entity",
"type": "progene_text",
"text": [
"MAPK"
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"offsets": [
[
56,
60
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],
"normalized": []
},
{
"id": "split_0_train_45051_entity",
"type": "progene_text",
"text": [
"AP-1"
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111,
115
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],
"normalized": []
},
{
"id": "split_0_train_45052_entity",
"type": "progene_text",
"text": [
"Fra-2"
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"offsets": [
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190,
195
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],
"normalized": []
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{
"id": "split_0_train_45053_entity",
"type": "progene_text",
"text": [
"fra-2"
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"offsets": [
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204,
209
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],
"normalized": []
},
{
"id": "split_0_train_45054_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
229,
233
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27823
|
split_0_train_27823
|
[
{
"id": "split_0_train_27823_passage",
"type": "progene_text",
"text": [
"We also localized the Fra-2 phosphorylation sites by MAPK to three threonine and three serine residues in the COOH - terminal region by means of site - directed mutagenesis and showed that the threonine residues were more susceptible to MAPK ."
],
"offsets": [
[
0,
243
]
]
}
] |
[
{
"id": "split_0_train_45055_entity",
"type": "progene_text",
"text": [
"Fra-2"
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"offsets": [
[
22,
27
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],
"normalized": []
},
{
"id": "split_0_train_45056_entity",
"type": "progene_text",
"text": [
"MAPK"
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"offsets": [
[
53,
57
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"normalized": []
},
{
"id": "split_0_train_45057_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
237,
241
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27824
|
split_0_train_27824
|
[
{
"id": "split_0_train_27824_passage",
"type": "progene_text",
"text": [
"Carbon regulation of ribosomal genes in Neurospora crassa occurs by a mechanism which does not require Cre-1 , the homologue of the Aspergillus carbon catabolite repressor , CreA ."
],
"offsets": [
[
0,
180
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]
}
] |
[
{
"id": "split_0_train_45058_entity",
"type": "progene_text",
"text": [
"Cre-1"
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103,
108
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],
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},
{
"id": "split_0_train_45059_entity",
"type": "progene_text",
"text": [
"carbon catabolite repressor"
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144,
171
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{
"id": "split_0_train_45060_entity",
"type": "progene_text",
"text": [
"CreA"
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"offsets": [
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174,
178
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27825
|
split_0_train_27825
|
[
{
"id": "split_0_train_27825_passage",
"type": "progene_text",
"text": [
"Transcription of the ribosomal protein and 40S rRNA genes is coordinately regulated during steady state growth and carbon shifts in Neurospora crassa ."
],
"offsets": [
[
0,
151
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27826
|
split_0_train_27826
|
[
{
"id": "split_0_train_27826_passage",
"type": "progene_text",
"text": [
"Recognition sequences for the Aspergillus nidulans carbon catabolite repressor , CreA , overlap transcriptional elements of a 40S rRNA gene and the crp-2 ribosomal protein gene ."
],
"offsets": [
[
0,
178
]
]
}
] |
[
{
"id": "split_0_train_45061_entity",
"type": "progene_text",
"text": [
"CreA"
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"offsets": [
[
81,
85
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],
"normalized": []
},
{
"id": "split_0_train_45062_entity",
"type": "progene_text",
"text": [
"crp-2"
],
"offsets": [
[
148,
153
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27827
|
split_0_train_27827
|
[
{
"id": "split_0_train_27827_passage",
"type": "progene_text",
"text": [
"They also occur in similar locations in the promoters of several other ribosomal protein genes ."
],
"offsets": [
[
0,
96
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27828
|
split_0_train_27828
|
[
{
"id": "split_0_train_27828_passage",
"type": "progene_text",
"text": [
"Substitutions encompassing the - 74 and - 167 CreA consensus sequences in the crp-2 promoter result in a decrease in transcription ."
],
"offsets": [
[
0,
132
]
]
}
] |
[
{
"id": "split_0_train_45063_entity",
"type": "progene_text",
"text": [
"CreA"
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"offsets": [
[
46,
50
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"id": "split_0_train_45064_entity",
"type": "progene_text",
"text": [
"crp-2"
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[
78,
83
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27829
|
split_0_train_27829
|
[
{
"id": "split_0_train_27829_passage",
"type": "progene_text",
"text": [
"A cDNA encoding the N. crassa homologue of CreA was cloned and designated Cre-1 ."
],
"offsets": [
[
0,
81
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]
}
] |
[
{
"id": "split_0_train_45065_entity",
"type": "progene_text",
"text": [
"CreA"
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43,
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{
"id": "split_0_train_45066_entity",
"type": "progene_text",
"text": [
"Cre-1"
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"offsets": [
[
74,
79
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27830
|
split_0_train_27830
|
[
{
"id": "split_0_train_27830_passage",
"type": "progene_text",
"text": [
"The Cre-1 protein is 45 % identical to CreA from A. nidulans ."
],
"offsets": [
[
0,
62
]
]
}
] |
[
{
"id": "split_0_train_45067_entity",
"type": "progene_text",
"text": [
"Cre-1"
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4,
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{
"id": "split_0_train_45068_entity",
"type": "progene_text",
"text": [
"CreA"
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"offsets": [
[
39,
43
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27831
|
split_0_train_27831
|
[
{
"id": "split_0_train_27831_passage",
"type": "progene_text",
"text": [
"Cre-1 protein produced in Escherichia coli binds to the CreA sites in the promoters of the 40S rRNA and crp-2 genes ."
],
"offsets": [
[
0,
117
]
]
}
] |
[
{
"id": "split_0_train_45069_entity",
"type": "progene_text",
"text": [
"Cre-1"
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0,
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"id": "split_0_train_45070_entity",
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"text": [
"CreA"
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56,
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{
"id": "split_0_train_45071_entity",
"type": "progene_text",
"text": [
"crp-2"
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"offsets": [
[
104,
109
]
],
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}
] |
[] |
[] |
[] |
split_0_train_27832
|
split_0_train_27832
|
[
{
"id": "split_0_train_27832_passage",
"type": "progene_text",
"text": [
"An amino acid change from histidine ( 92 ) to threonine changed the Cre-1 binding specificity from ( 5' G / CC / TGGG / AG3' ) to ( 5'G / CC / TGGCG3 ' ) ."
],
"offsets": [
[
0,
155
]
]
}
] |
[
{
"id": "split_0_train_45072_entity",
"type": "progene_text",
"text": [
"Cre-1"
],
"offsets": [
[
68,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27833
|
split_0_train_27833
|
[
{
"id": "split_0_train_27833_passage",
"type": "progene_text",
"text": [
"Base substitutions in the Cre-1 binding sites of the crp-2 promoter disrupted binding of wildtype Cre-1 in vitro but had no effect on transcription during steady state growth or carbon shifts , indicating that regulation of ribosomal genes by carbon source is not mediated by Cre-1 , but via different proteins binding the Cre-1 sites and the Dde boxes ."
],
"offsets": [
[
0,
354
]
]
}
] |
[
{
"id": "split_0_train_45073_entity",
"type": "progene_text",
"text": [
"Cre-1"
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[
26,
31
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{
"id": "split_0_train_45074_entity",
"type": "progene_text",
"text": [
"crp-2"
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53,
58
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{
"id": "split_0_train_45075_entity",
"type": "progene_text",
"text": [
"Cre-1"
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98,
103
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},
{
"id": "split_0_train_45076_entity",
"type": "progene_text",
"text": [
"Cre-1"
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276,
281
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},
{
"id": "split_0_train_45077_entity",
"type": "progene_text",
"text": [
"Cre-1"
],
"offsets": [
[
323,
328
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27834
|
split_0_train_27834
|
[
{
"id": "split_0_train_27834_passage",
"type": "progene_text",
"text": [
"Suppression of SHP-2 and ERK signalling promotes self - renewal of mouse embryonic stem cells ."
],
"offsets": [
[
0,
95
]
]
}
] |
[
{
"id": "split_0_train_45078_entity",
"type": "progene_text",
"text": [
"SHP-2"
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[
15,
20
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],
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{
"id": "split_0_train_45079_entity",
"type": "progene_text",
"text": [
"ERK"
],
"offsets": [
[
25,
28
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27835
|
split_0_train_27835
|
[
{
"id": "split_0_train_27835_passage",
"type": "progene_text",
"text": [
"The propagation of pluripotent mouse embryonic stem ( ES ) cells depends on signals transduced through the cytokine receptor subunit gp130 ."
],
"offsets": [
[
0,
140
]
]
}
] |
[
{
"id": "split_0_train_45080_entity",
"type": "progene_text",
"text": [
"cytokine receptor"
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[
107,
124
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{
"id": "split_0_train_45081_entity",
"type": "progene_text",
"text": [
"gp130"
],
"offsets": [
[
133,
138
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27836
|
split_0_train_27836
|
[
{
"id": "split_0_train_27836_passage",
"type": "progene_text",
"text": [
"Signalling molecules activated downstream of gp130 in ES cells include STAT3 , the protein tyrosine phosphatase SHP-2 , and the mitogen - activated protein kinases , ERK1 and ERK2 ."
],
"offsets": [
[
0,
181
]
]
}
] |
[
{
"id": "split_0_train_45082_entity",
"type": "progene_text",
"text": [
"gp130"
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[
45,
50
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},
{
"id": "split_0_train_45083_entity",
"type": "progene_text",
"text": [
"STAT3"
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[
71,
76
]
],
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},
{
"id": "split_0_train_45084_entity",
"type": "progene_text",
"text": [
"protein tyrosine phosphatase"
],
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[
83,
111
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],
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},
{
"id": "split_0_train_45085_entity",
"type": "progene_text",
"text": [
"SHP-2"
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[
112,
117
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],
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},
{
"id": "split_0_train_45086_entity",
"type": "progene_text",
"text": [
"mitogen - activated protein kinases"
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[
128,
163
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],
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},
{
"id": "split_0_train_45087_entity",
"type": "progene_text",
"text": [
"ERK1"
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[
166,
170
]
],
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},
{
"id": "split_0_train_45088_entity",
"type": "progene_text",
"text": [
"ERK2"
],
"offsets": [
[
175,
179
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27837
|
split_0_train_27837
|
[
{
"id": "split_0_train_27837_passage",
"type": "progene_text",
"text": [
"A chimaeric receptor in which tyrosine 118 in the gp130 cytoplasmic domain was mutated did not engage SHP-2 and failed to activate ERKs ."
],
"offsets": [
[
0,
137
]
]
}
] |
[
{
"id": "split_0_train_45089_entity",
"type": "progene_text",
"text": [
"gp130"
],
"offsets": [
[
50,
55
]
],
"normalized": []
},
{
"id": "split_0_train_45090_entity",
"type": "progene_text",
"text": [
"SHP-2"
],
"offsets": [
[
102,
107
]
],
"normalized": []
},
{
"id": "split_0_train_45091_entity",
"type": "progene_text",
"text": [
"ERKs"
],
"offsets": [
[
131,
135
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27838
|
split_0_train_27838
|
[
{
"id": "split_0_train_27838_passage",
"type": "progene_text",
"text": [
"However , this receptor did support ES cell self - renewal ."
],
"offsets": [
[
0,
60
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27839
|
split_0_train_27839
|
[
{
"id": "split_0_train_27839_passage",
"type": "progene_text",
"text": [
"In fact , stem cell colonies formed at 100 - fold lower concentrations of cytokine than the unmodified receptor ."
],
"offsets": [
[
0,
113
]
]
}
] |
[
{
"id": "split_0_train_45092_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
74,
82
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27840
|
split_0_train_27840
|
[
{
"id": "split_0_train_27840_passage",
"type": "progene_text",
"text": [
"Moreover , altered ES cell morphology and growth were observed at high cytokine concentrations ."
],
"offsets": [
[
0,
96
]
]
}
] |
[
{
"id": "split_0_train_45093_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
71,
79
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27841
|
split_0_train_27841
|
[
{
"id": "split_0_train_27841_passage",
"type": "progene_text",
"text": [
"These indications of deregulated signalling in the absence of tyrosine 118 were substantiated by sustained activation of STAT3 ."
],
"offsets": [
[
0,
128
]
]
}
] |
[
{
"id": "split_0_train_45094_entity",
"type": "progene_text",
"text": [
"STAT3"
],
"offsets": [
[
121,
126
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27842
|
split_0_train_27842
|
[
{
"id": "split_0_train_27842_passage",
"type": "progene_text",
"text": [
"Confirmation that ERK activation is not required for self - renewal was obtained by propagation of pluripotent ES cells in the presence of the MEK inhibitor PD098059 ."
],
"offsets": [
[
0,
167
]
]
}
] |
[
{
"id": "split_0_train_45095_entity",
"type": "progene_text",
"text": [
"ERK"
],
"offsets": [
[
18,
21
]
],
"normalized": []
},
{
"id": "split_0_train_45096_entity",
"type": "progene_text",
"text": [
"MEK"
],
"offsets": [
[
143,
146
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27843
|
split_0_train_27843
|
[
{
"id": "split_0_train_27843_passage",
"type": "progene_text",
"text": [
"In fact , the growth of undifferentiated ES cells was enhanced by culture in PD098059 ."
],
"offsets": [
[
0,
87
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27844
|
split_0_train_27844
|
[
{
"id": "split_0_train_27844_passage",
"type": "progene_text",
"text": [
"Thus activation of ERKs appears actively to impair self - renewal ."
],
"offsets": [
[
0,
67
]
]
}
] |
[
{
"id": "split_0_train_45097_entity",
"type": "progene_text",
"text": [
"ERKs"
],
"offsets": [
[
19,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27845
|
split_0_train_27845
|
[
{
"id": "split_0_train_27845_passage",
"type": "progene_text",
"text": [
"These data imply that the self - renewal signal from gp130 is a finely tuned balance of positive and negative effectors ."
],
"offsets": [
[
0,
121
]
]
}
] |
[
{
"id": "split_0_train_45098_entity",
"type": "progene_text",
"text": [
"gp130"
],
"offsets": [
[
53,
58
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27846
|
split_0_train_27846
|
[
{
"id": "split_0_train_27846_passage",
"type": "progene_text",
"text": [
"Effects of in vitro hemolysis on serum biochemistry values of the bottlenose dolphin ( Tursiops truncatus ) ."
],
"offsets": [
[
0,
109
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27847
|
split_0_train_27847
|
[
{
"id": "split_0_train_27847_passage",
"type": "progene_text",
"text": [
"The effects of in vitro hemolysis on 23 biochemical analytes were assessed in sera from 14 clinically healthy Atlantic bottlenose dolphins ( Tursiops truncatus ) ."
],
"offsets": [
[
0,
163
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27848
|
split_0_train_27848
|
[
{
"id": "split_0_train_27848_passage",
"type": "progene_text",
"text": [
"Each serum sample was divided into three portions for analysis : 1 ) nonhemolyzed control ; 2) moderate hemolysis , simulated by adding hemolyzed serum to a final concentration of approximately 150 mg / dl Hb ; and 3 ) severe hemolysis , simulated by adding hemolyzed serum to a final concentration of approximately 500 mg / dl Hb ."
],
"offsets": [
[
0,
332
]
]
}
] |
[
{
"id": "split_0_train_45099_entity",
"type": "progene_text",
"text": [
"Hb"
],
"offsets": [
[
328,
330
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27849
|
split_0_train_27849
|
[
{
"id": "split_0_train_27849_passage",
"type": "progene_text",
"text": [
"Moderate hemolysis resulted in statistically significant increases in the mean values of iron , lactate dehydrogenase , potassium , and uric acid and a decrease in creatinine ( P < 0.001 ) ."
],
"offsets": [
[
0,
190
]
]
}
] |
[
{
"id": "split_0_train_45100_entity",
"type": "progene_text",
"text": [
"lactate dehydrogenase"
],
"offsets": [
[
96,
117
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27850
|
split_0_train_27850
|
[
{
"id": "split_0_train_27850_passage",
"type": "progene_text",
"text": [
"Severe hemolysis resulted in statistically significant changes in the mean values of the above analytes in addition to the following increases : alanine aminotransferase , calcium , and serum globulins ( P < 0.001 ) and albumin and total protein ( P < 0.01 ) ."
],
"offsets": [
[
0,
260
]
]
}
] |
[
{
"id": "split_0_train_45101_entity",
"type": "progene_text",
"text": [
"alanine aminotransferase"
],
"offsets": [
[
145,
169
]
],
"normalized": []
},
{
"id": "split_0_train_45102_entity",
"type": "progene_text",
"text": [
"albumin"
],
"offsets": [
[
220,
227
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27851
|
split_0_train_27851
|
[
{
"id": "split_0_train_27851_passage",
"type": "progene_text",
"text": [
"Total bilirubin and gamma glutamyl transferase levels were lower in the severely hemolyzed sample ( P < 0.001 ) ."
],
"offsets": [
[
0,
113
]
]
}
] |
[
{
"id": "split_0_train_45103_entity",
"type": "progene_text",
"text": [
"gamma glutamyl transferase"
],
"offsets": [
[
20,
46
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27852
|
split_0_train_27852
|
[
{
"id": "split_0_train_27852_passage",
"type": "progene_text",
"text": [
"Differences in mean values for alkaline phosphatase between nonhemolyzed and hemolyzed serum were not significant but did show a downward trend in the hemolyzed sera ."
],
"offsets": [
[
0,
167
]
]
}
] |
[
{
"id": "split_0_train_45104_entity",
"type": "progene_text",
"text": [
"alkaline phosphatase"
],
"offsets": [
[
31,
51
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27853
|
split_0_train_27853
|
[
{
"id": "split_0_train_27853_passage",
"type": "progene_text",
"text": [
"The presence and severity of hemolysis must be considered in the interpretation of the serum chemistry values ."
],
"offsets": [
[
0,
111
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27854
|
split_0_train_27854
|
[
{
"id": "split_0_train_27854_passage",
"type": "progene_text",
"text": [
"Turbutest in the training of asthmatic Turbuhaler users ."
],
"offsets": [
[
0,
57
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27855
|
split_0_train_27855
|
[
{
"id": "split_0_train_27855_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27856
|
split_0_train_27856
|
[
{
"id": "split_0_train_27856_passage",
"type": "progene_text",
"text": [
"Correct utilization of inhalation devices is a key factor in asthma management ."
],
"offsets": [
[
0,
80
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27857
|
split_0_train_27857
|
[
{
"id": "split_0_train_27857_passage",
"type": "progene_text",
"text": [
"Objective assessment of the ability to use inhaler devices is therefore fundamental ."
],
"offsets": [
[
0,
85
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27858
|
split_0_train_27858
|
[
{
"id": "split_0_train_27858_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27859
|
split_0_train_27859
|
[
{
"id": "split_0_train_27859_passage",
"type": "progene_text",
"text": [
"The objective was to assess objectively the inhalation technique of Turbuhaler users who reported having no difficulty in using such a device ."
],
"offsets": [
[
0,
143
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27860
|
split_0_train_27860
|
[
{
"id": "split_0_train_27860_passage",
"type": "progene_text",
"text": [
"A total of 600 asthmatic patients of our allergology outpatient department , daily users of Turbuhaler devices , were evaluated with Turbutest ."
],
"offsets": [
[
0,
144
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27861
|
split_0_train_27861
|
[
{
"id": "split_0_train_27861_passage",
"type": "progene_text",
"text": [
"This is a simple portable apparatus which connects a Turbuhaler inhaler with an electronic device to allow semiquantitative assessment of inhalation technique , with a score ranging from 0 ( worst ) to 3 ( best ) , readily visualized on the apparatus ."
],
"offsets": [
[
0,
252
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27862
|
split_0_train_27862
|
[
{
"id": "split_0_train_27862_passage",
"type": "progene_text",
"text": [
"Patients were allowed to practice with Turbutest , assisted by an allergologist , until they improved their scores ."
],
"offsets": [
[
0,
116
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27863
|
split_0_train_27863
|
[
{
"id": "split_0_train_27863_passage",
"type": "progene_text",
"text": [
"A second Turbutest assessment was performed at a 2 - month follow - up visit ."
],
"offsets": [
[
0,
78
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27864
|
split_0_train_27864
|
[
{
"id": "split_0_train_27864_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27865
|
split_0_train_27865
|
[
{
"id": "split_0_train_27865_passage",
"type": "progene_text",
"text": [
"On the first assessment , one - third of the patients had scores inadequate to allow a good inhalation , and only 20 % achieved a score of 3 ."
],
"offsets": [
[
0,
142
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27866
|
split_0_train_27866
|
[
{
"id": "split_0_train_27866_passage",
"type": "progene_text",
"text": [
"On the second assessment , significantly higher Turbutest scores were observed ."
],
"offsets": [
[
0,
80
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27867
|
split_0_train_27867
|
[
{
"id": "split_0_train_27867_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27868
|
split_0_train_27868
|
[
{
"id": "split_0_train_27868_passage",
"type": "progene_text",
"text": [
"Turbutest is a valuable tool in asthmatic patients ' training , allowing identification and improvement of an inadequate inhalation technique with Turbuhaler ."
],
"offsets": [
[
0,
159
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27869
|
split_0_train_27869
|
[
{
"id": "split_0_train_27869_passage",
"type": "progene_text",
"text": [
"Effect of a single bolus of intracoronary basic fibroblast growth factor on perfusion in an ischemic porcine model ."
],
"offsets": [
[
0,
116
]
]
}
] |
[
{
"id": "split_0_train_45105_entity",
"type": "progene_text",
"text": [
"basic fibroblast growth factor"
],
"offsets": [
[
42,
72
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27870
|
split_0_train_27870
|
[
{
"id": "split_0_train_27870_passage",
"type": "progene_text",
"text": [
"Basic fibroblast growth factor ( bFGF ) has been shown to induce angiogenesis in various animal models , but the methods of administration used experimentally are not clinically feasible ."
],
"offsets": [
[
0,
188
]
]
}
] |
[
{
"id": "split_0_train_45106_entity",
"type": "progene_text",
"text": [
"Basic fibroblast growth factor"
],
"offsets": [
[
0,
30
]
],
"normalized": []
},
{
"id": "split_0_train_45107_entity",
"type": "progene_text",
"text": [
"bFGF"
],
"offsets": [
[
33,
37
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27871
|
split_0_train_27871
|
[
{
"id": "split_0_train_27871_passage",
"type": "progene_text",
"text": [
"The objective of this study was to determine whether a single intracoronary bolus injection of bFGF would improve coronary perfusion in a porcine ischemic model that mimics clinical chronic ischemia ."
],
"offsets": [
[
0,
200
]
]
}
] |
[
{
"id": "split_0_train_45108_entity",
"type": "progene_text",
"text": [
"bFGF"
],
"offsets": [
[
95,
99
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27872
|
split_0_train_27872
|
[
{
"id": "split_0_train_27872_passage",
"type": "progene_text",
"text": [
"A copper coil studded with gold was delivered into the proximal right coronary artery of juvenile Yorkshire pigs and deployed by interventional techniques ."
],
"offsets": [
[
0,
156
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27873
|
split_0_train_27873
|
[
{
"id": "split_0_train_27873_passage",
"type": "progene_text",
"text": [
"After a four - week interval for stenosis maturation , bFGF ( 100 micrograms ) was administered by bolus injection into the left coronary artery in five animals , and vehicle alone was administered in four animals ."
],
"offsets": [
[
0,
215
]
]
}
] |
[
{
"id": "split_0_train_45109_entity",
"type": "progene_text",
"text": [
"bFGF"
],
"offsets": [
[
55,
59
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27874
|
split_0_train_27874
|
[
{
"id": "split_0_train_27874_passage",
"type": "progene_text",
"text": [
"Angiogenesis and change in right coronary perfusion area were assessed two weeks later by angiography , myocardial contrast echocardiography and immunohistochemistry ."
],
"offsets": [
[
0,
167
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27875
|
split_0_train_27875
|
[
{
"id": "split_0_train_27875_passage",
"type": "progene_text",
"text": [
"The right coronary perfusion area increased significantly after treatment in all but one of the animals that received bFGF but not in any of the controls ."
],
"offsets": [
[
0,
155
]
]
}
] |
[
{
"id": "split_0_train_45110_entity",
"type": "progene_text",
"text": [
"bFGF"
],
"offsets": [
[
118,
122
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27876
|
split_0_train_27876
|
[
{
"id": "split_0_train_27876_passage",
"type": "progene_text",
"text": [
"Intimal hyperplasia was not induced by bFGF ."
],
"offsets": [
[
0,
45
]
]
}
] |
[
{
"id": "split_0_train_45111_entity",
"type": "progene_text",
"text": [
"bFGF"
],
"offsets": [
[
39,
43
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27877
|
split_0_train_27877
|
[
{
"id": "split_0_train_27877_passage",
"type": "progene_text",
"text": [
"Capillary density determined histochemically was not different in the two groups ."
],
"offsets": [
[
0,
82
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27878
|
split_0_train_27878
|
[
{
"id": "split_0_train_27878_passage",
"type": "progene_text",
"text": [
"In conclusion , in a porcine ischemic model , bFGF administered by a single bolus intracoronary injection into the contralateral artery improved antegrade perfusion into the ischemic territory although without histological evidence of angiogenesis ."
],
"offsets": [
[
0,
249
]
]
}
] |
[
{
"id": "split_0_train_45112_entity",
"type": "progene_text",
"text": [
"bFGF"
],
"offsets": [
[
46,
50
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27879
|
split_0_train_27879
|
[
{
"id": "split_0_train_27879_passage",
"type": "progene_text",
"text": [
"This preliminary work merits further investigation ."
],
"offsets": [
[
0,
52
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27880
|
split_0_train_27880
|
[
{
"id": "split_0_train_27880_passage",
"type": "progene_text",
"text": [
"On the possible role of the nitrogen atom in living matter ."
],
"offsets": [
[
0,
60
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27881
|
split_0_train_27881
|
[
{
"id": "split_0_train_27881_passage",
"type": "progene_text",
"text": [
"Molecules of NH3 are capable of emitting stimulated radiation ( MASER ) ."
],
"offsets": [
[
0,
73
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27882
|
split_0_train_27882
|
[
{
"id": "split_0_train_27882_passage",
"type": "progene_text",
"text": [
"Their organic derivates could have a similar effect , as is suggested by the new results published in Electron Correlations in Molecules and Solids [ P. Fulde , Electron Correlations in Molecules and Solids , Springer - Verlag , Berlin , Heidelberg , 1993 ] ."
],
"offsets": [
[
0,
259
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27883
|
split_0_train_27883
|
[
{
"id": "split_0_train_27883_passage",
"type": "progene_text",
"text": [
"A double interaction screen identifies positive and negative ftz gene regulators and ftz - interacting proteins ."
],
"offsets": [
[
0,
113
]
]
}
] |
[
{
"id": "split_0_train_45113_entity",
"type": "progene_text",
"text": [
"ftz"
],
"offsets": [
[
61,
64
]
],
"normalized": []
},
{
"id": "split_0_train_45114_entity",
"type": "progene_text",
"text": [
"ftz"
],
"offsets": [
[
85,
88
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27884
|
split_0_train_27884
|
[
{
"id": "split_0_train_27884_passage",
"type": "progene_text",
"text": [
"Regulatory genes directing embryonic development are expressed in complex patterns ."
],
"offsets": [
[
0,
84
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27885
|
split_0_train_27885
|
[
{
"id": "split_0_train_27885_passage",
"type": "progene_text",
"text": [
"The Drosophila homeobox gene fushi tarazu ( ftz ) is expressed in a striped pattern that is controlled by several discrete and large cis - regulatory elements ."
],
"offsets": [
[
0,
160
]
]
}
] |
[
{
"id": "split_0_train_45115_entity",
"type": "progene_text",
"text": [
"fushi tarazu"
],
"offsets": [
[
29,
41
]
],
"normalized": []
},
{
"id": "split_0_train_45116_entity",
"type": "progene_text",
"text": [
"ftz"
],
"offsets": [
[
44,
47
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27886
|
split_0_train_27886
|
[
{
"id": "split_0_train_27886_passage",
"type": "progene_text",
"text": [
"One key cis - element is the ftz proximal enhancer which is required for stripe establishment and which mediates autoregulation by direct binding of Ftz protein ."
],
"offsets": [
[
0,
162
]
]
}
] |
[
{
"id": "split_0_train_45117_entity",
"type": "progene_text",
"text": [
"ftz"
],
"offsets": [
[
29,
32
]
],
"normalized": []
},
{
"id": "split_0_train_45118_entity",
"type": "progene_text",
"text": [
"Ftz"
],
"offsets": [
[
149,
152
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27887
|
split_0_train_27887
|
[
{
"id": "split_0_train_27887_passage",
"type": "progene_text",
"text": [
"To identify the trans - acting factors that regulate ftz expression and autoregulation , we developed a modified yeast two hybrid screen , the Double Interaction Screen ( DIS ) ."
],
"offsets": [
[
0,
178
]
]
}
] |
[
{
"id": "split_0_train_45119_entity",
"type": "progene_text",
"text": [
"ftz"
],
"offsets": [
[
53,
56
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27888
|
split_0_train_27888
|
[
{
"id": "split_0_train_27888_passage",
"type": "progene_text",
"text": [
"The DIS was designed to isolate both DNA binding transcriptional regulators that interact with the proximal enhancer and proteins that interact with Ftz itself when it is bound to the enhancer ."
],
"offsets": [
[
0,
194
]
]
}
] |
[
{
"id": "split_0_train_45120_entity",
"type": "progene_text",
"text": [
"Ftz"
],
"offsets": [
[
149,
152
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27889
|
split_0_train_27889
|
[
{
"id": "split_0_train_27889_passage",
"type": "progene_text",
"text": [
"The screen identified two candidate Ftz protein cofactors as well as activators and repressors of ftz transcription that bind directly to the enhancer ."
],
"offsets": [
[
0,
152
]
]
}
] |
[
{
"id": "split_0_train_45121_entity",
"type": "progene_text",
"text": [
"Ftz"
],
"offsets": [
[
36,
39
]
],
"normalized": []
},
{
"id": "split_0_train_45122_entity",
"type": "progene_text",
"text": [
"ftz"
],
"offsets": [
[
98,
101
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27890
|
split_0_train_27890
|
[
{
"id": "split_0_train_27890_passage",
"type": "progene_text",
"text": [
"One of these ( Tramtrack ( Ttk ) ) was previously shown to bind to at least five sites in the proximal enhancer ; genetic studies suggested that Ttk acts as a repressor of ftz in the embryo ."
],
"offsets": [
[
0,
191
]
]
}
] |
[
{
"id": "split_0_train_45123_entity",
"type": "progene_text",
"text": [
"Tramtrack"
],
"offsets": [
[
15,
24
]
],
"normalized": []
},
{
"id": "split_0_train_45124_entity",
"type": "progene_text",
"text": [
"Ttk"
],
"offsets": [
[
27,
30
]
],
"normalized": []
},
{
"id": "split_0_train_45125_entity",
"type": "progene_text",
"text": [
"Ttk"
],
"offsets": [
[
145,
148
]
],
"normalized": []
},
{
"id": "split_0_train_45126_entity",
"type": "progene_text",
"text": [
"ftz"
],
"offsets": [
[
172,
175
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27891
|
split_0_train_27891
|
[
{
"id": "split_0_train_27891_passage",
"type": "progene_text",
"text": [
"Here we show that , in yeast cells , Ttk protein strongly activates transcription , suggesting that yeast may be missing a necessary co - repressor which is present in Drosophila embryos ."
],
"offsets": [
[
0,
188
]
]
}
] |
[
{
"id": "split_0_train_45127_entity",
"type": "progene_text",
"text": [
"Ttk"
],
"offsets": [
[
37,
40
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27892
|
split_0_train_27892
|
[
{
"id": "split_0_train_27892_passage",
"type": "progene_text",
"text": [
"Further , we have characterized the activity of a second candidate ftz repressor isolated in the screen - the product of the pair - rule gene sloppy paired - a member of the forkhead family ."
],
"offsets": [
[
0,
191
]
]
}
] |
[
{
"id": "split_0_train_45128_entity",
"type": "progene_text",
"text": [
"ftz"
],
"offsets": [
[
67,
70
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27893
|
split_0_train_27893
|
[
{
"id": "split_0_train_27893_passage",
"type": "progene_text",
"text": [
"We show that Slp1 is a DNA binding protein ."
],
"offsets": [
[
0,
44
]
]
}
] |
[
{
"id": "split_0_train_45129_entity",
"type": "progene_text",
"text": [
"Slp1"
],
"offsets": [
[
13,
17
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27894
|
split_0_train_27894
|
[
{
"id": "split_0_train_27894_passage",
"type": "progene_text",
"text": [
"We have identified a high affinity binding site for Slp1 in the ftz proximal enhancer ."
],
"offsets": [
[
0,
87
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27895
|
split_0_train_27895
|
[
{
"id": "split_0_train_27895_passage",
"type": "progene_text",
"text": [
"Slp1 represses transcription via this binding site in yeast cells , consistent with its role as a direct repressor of ftz stripes in interstripe regions during late stages of embryogenesis ."
],
"offsets": [
[
0,
190
]
]
}
] |
[
{
"id": "split_0_train_45130_entity",
"type": "progene_text",
"text": [
"Slp1"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_45131_entity",
"type": "progene_text",
"text": [
"ftz"
],
"offsets": [
[
118,
121
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_27896
|
split_0_train_27896
|
[
{
"id": "split_0_train_27896_passage",
"type": "progene_text",
"text": [
"The DIS should be a generally useful method to identify DNA binding transcriptional regulators and protein partners of previously characterized DNA binding proteins ."
],
"offsets": [
[
0,
166
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27897
|
split_0_train_27897
|
[
{
"id": "split_0_train_27897_passage",
"type": "progene_text",
"text": [
"Method for detection and enumeration of Cryptosporidium parvum oocysts in feces , manures , and soils ."
],
"offsets": [
[
0,
103
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27898
|
split_0_train_27898
|
[
{
"id": "split_0_train_27898_passage",
"type": "progene_text",
"text": [
"Eight concentration and purification methods were evaluated to determine percentages of recovery of Cryptosporidium parvum oocysts from calf feces ."
],
"offsets": [
[
0,
148
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_27899
|
split_0_train_27899
|
[
{
"id": "split_0_train_27899_passage",
"type": "progene_text",
"text": [
"The NaCl flotation method generally resulted in the highest percentages of recovery ."
],
"offsets": [
[
0,
85
]
]
}
] |
[] |
[] |
[] |
[] |
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