id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_28000
|
split_0_train_28000
|
[
{
"id": "split_0_train_28000_passage",
"type": "progene_text",
"text": [
"However , the previously characterized mutation cdc4 - 1 and a new allele , cdc4 - 12 , do not alleviate the defect of cdc20 - 1 cells ."
],
"offsets": [
[
0,
136
]
]
}
] |
[
{
"id": "split_0_train_45333_entity",
"type": "progene_text",
"text": [
"cdc4"
],
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[
48,
52
]
],
"normalized": []
},
{
"id": "split_0_train_45334_entity",
"type": "progene_text",
"text": [
"cdc4"
],
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[
76,
80
]
],
"normalized": []
},
{
"id": "split_0_train_45335_entity",
"type": "progene_text",
"text": [
"cdc20"
],
"offsets": [
[
119,
124
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28001
|
split_0_train_28001
|
[
{
"id": "split_0_train_28001_passage",
"type": "progene_text",
"text": [
"This genetic interaction suggests an additional role for Cdc4 in G(2) / M ."
],
"offsets": [
[
0,
75
]
]
}
] |
[
{
"id": "split_0_train_45336_entity",
"type": "progene_text",
"text": [
"Cdc4"
],
"offsets": [
[
57,
61
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28002
|
split_0_train_28002
|
[
{
"id": "split_0_train_28002_passage",
"type": "progene_text",
"text": [
"Reexamination of the cdc4 - 1 mutant revealed that , in addition to being defective in the onset of S phase , it is also defective in G(2) / M transition when released from hydroxyurea - induced S-phase arrest ."
],
"offsets": [
[
0,
211
]
]
}
] |
[
{
"id": "split_0_train_45337_entity",
"type": "progene_text",
"text": [
"cdc4"
],
"offsets": [
[
21,
25
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28003
|
split_0_train_28003
|
[
{
"id": "split_0_train_28003_passage",
"type": "progene_text",
"text": [
"A second function for CDC4 in late S or G(2) phase was further confirmed by the observation that cells lacking the CDC4 gene are arrested both at G(1) / S and at G(2)/M ."
],
"offsets": [
[
0,
170
]
]
}
] |
[
{
"id": "split_0_train_45338_entity",
"type": "progene_text",
"text": [
"CDC4"
],
"offsets": [
[
22,
26
]
],
"normalized": []
},
{
"id": "split_0_train_45339_entity",
"type": "progene_text",
"text": [
"CDC4"
],
"offsets": [
[
115,
119
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28004
|
split_0_train_28004
|
[
{
"id": "split_0_train_28004_passage",
"type": "progene_text",
"text": [
"We subsequently isolated additional temperature - sensitive mutations in the CDC4 gene ( such as cdc4 - 12 ) that render the mutant defective in both G(1) / S and G(2) / M transitions at the restrictive temperature ."
],
"offsets": [
[
0,
216
]
]
}
] |
[
{
"id": "split_0_train_45340_entity",
"type": "progene_text",
"text": [
"CDC4"
],
"offsets": [
[
77,
81
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],
"normalized": []
},
{
"id": "split_0_train_45341_entity",
"type": "progene_text",
"text": [
"cdc4"
],
"offsets": [
[
97,
101
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28005
|
split_0_train_28005
|
[
{
"id": "split_0_train_28005_passage",
"type": "progene_text",
"text": [
"While the G(1) / S block in both cdc4 - 12 and cdc4Delta mutants is abolished by the deletion of the SIC1 gene ( causing the mutants to be arrested predominantly in G(2) / M ) , the preanaphase arrest in the cdc4 - 12 mutant is relieved by the deletion of PDS1 ."
],
"offsets": [
[
0,
262
]
]
}
] |
[
{
"id": "split_0_train_45342_entity",
"type": "progene_text",
"text": [
"cdc4"
],
"offsets": [
[
33,
37
]
],
"normalized": []
},
{
"id": "split_0_train_45343_entity",
"type": "progene_text",
"text": [
"cdc4Delta"
],
"offsets": [
[
47,
56
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],
"normalized": []
},
{
"id": "split_0_train_45344_entity",
"type": "progene_text",
"text": [
"SIC1"
],
"offsets": [
[
101,
105
]
],
"normalized": []
},
{
"id": "split_0_train_45345_entity",
"type": "progene_text",
"text": [
"cdc4"
],
"offsets": [
[
208,
212
]
],
"normalized": []
},
{
"id": "split_0_train_45346_entity",
"type": "progene_text",
"text": [
"PDS1"
],
"offsets": [
[
256,
260
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28006
|
split_0_train_28006
|
[
{
"id": "split_0_train_28006_passage",
"type": "progene_text",
"text": [
"Collectively , these observations suggest that , in addition to its involvement in the initiation of S phase , Cdc4 may also be required for the onset of anaphase ."
],
"offsets": [
[
0,
164
]
]
}
] |
[
{
"id": "split_0_train_45347_entity",
"type": "progene_text",
"text": [
"Cdc4"
],
"offsets": [
[
111,
115
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28007
|
split_0_train_28007
|
[
{
"id": "split_0_train_28007_passage",
"type": "progene_text",
"text": [
"Required role of focal adhesion kinase ( FAK ) for integrin - stimulated cell migration ."
],
"offsets": [
[
0,
89
]
]
}
] |
[
{
"id": "split_0_train_45348_entity",
"type": "progene_text",
"text": [
"focal adhesion kinase"
],
"offsets": [
[
17,
38
]
],
"normalized": []
},
{
"id": "split_0_train_45349_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
41,
44
]
],
"normalized": []
},
{
"id": "split_0_train_45350_entity",
"type": "progene_text",
"text": [
"integrin"
],
"offsets": [
[
51,
59
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28008
|
split_0_train_28008
|
[
{
"id": "split_0_train_28008_passage",
"type": "progene_text",
"text": [
"FAK localizes to sites of transmembrane integrin receptor clustering and facilitates intracellular signaling events ."
],
"offsets": [
[
0,
117
]
]
}
] |
[
{
"id": "split_0_train_45351_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_45352_entity",
"type": "progene_text",
"text": [
"integrin"
],
"offsets": [
[
40,
48
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28009
|
split_0_train_28009
|
[
{
"id": "split_0_train_28009_passage",
"type": "progene_text",
"text": [
"FAK - null ( FAK - ) fibroblasts exhibit a rounded morphology , defects in cell migration , and an elevated number of cell - substratum contact sites ."
],
"offsets": [
[
0,
151
]
]
}
] |
[
{
"id": "split_0_train_45353_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_45354_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
13,
16
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28010
|
split_0_train_28010
|
[
{
"id": "split_0_train_28010_passage",
"type": "progene_text",
"text": [
"Here we show that stable re - expression of epitope - tagged FAK reversed the morphological defects of the FAK - cells through the dynamic regulation of actin structures and focal contact sites in fibronectin ( FN ) stimulated cells ."
],
"offsets": [
[
0,
234
]
]
}
] |
[
{
"id": "split_0_train_45355_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
61,
64
]
],
"normalized": []
},
{
"id": "split_0_train_45356_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
107,
110
]
],
"normalized": []
},
{
"id": "split_0_train_45357_entity",
"type": "progene_text",
"text": [
"fibronectin"
],
"offsets": [
[
197,
208
]
],
"normalized": []
},
{
"id": "split_0_train_45358_entity",
"type": "progene_text",
"text": [
"FN"
],
"offsets": [
[
211,
213
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28011
|
split_0_train_28011
|
[
{
"id": "split_0_train_28011_passage",
"type": "progene_text",
"text": [
"FAK re - expressing fibroblasts ( clones DA2 and DP3 ) exhibit a characteristic fibrillar shape and display indistinguishable FN receptor - stimulated migration properties compared to normal fibroblasts ."
],
"offsets": [
[
0,
204
]
]
}
] |
[
{
"id": "split_0_train_45359_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_45360_entity",
"type": "progene_text",
"text": [
"FN receptor"
],
"offsets": [
[
126,
137
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28012
|
split_0_train_28012
|
[
{
"id": "split_0_train_28012_passage",
"type": "progene_text",
"text": [
"Expression of various FAK mutants in the FAK - cells showed that FAK kinase activity , the Tyr - 397 / SH2 domain binding site , and the first proline - rich SH3 binding region in the FAK C - terminal domain were individually needed to promote full FAK - mediated FAK - cell migration to FN whereas direct paxillin binding to FAK was not required ."
],
"offsets": [
[
0,
348
]
]
}
] |
[
{
"id": "split_0_train_45361_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
22,
25
]
],
"normalized": []
},
{
"id": "split_0_train_45362_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
41,
44
]
],
"normalized": []
},
{
"id": "split_0_train_45363_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
65,
68
]
],
"normalized": []
},
{
"id": "split_0_train_45364_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
69,
75
]
],
"normalized": []
},
{
"id": "split_0_train_45365_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
184,
187
]
],
"normalized": []
},
{
"id": "split_0_train_45366_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
249,
252
]
],
"normalized": []
},
{
"id": "split_0_train_45367_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
264,
267
]
],
"normalized": []
},
{
"id": "split_0_train_45368_entity",
"type": "progene_text",
"text": [
"FN"
],
"offsets": [
[
288,
290
]
],
"normalized": []
},
{
"id": "split_0_train_45369_entity",
"type": "progene_text",
"text": [
"paxillin"
],
"offsets": [
[
306,
314
]
],
"normalized": []
},
{
"id": "split_0_train_45370_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
326,
329
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28013
|
split_0_train_28013
|
[
{
"id": "split_0_train_28013_passage",
"type": "progene_text",
"text": [
"Expression of the FAK Phe-397 mutant did not promote FAK - cell migration and overexpression of p50(csk) in DA2 cells inhibited migration to FN suggesting that Src-family PTKs play important roles in FAK - mediated motility events ."
],
"offsets": [
[
0,
232
]
]
}
] |
[
{
"id": "split_0_train_45371_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
18,
21
]
],
"normalized": []
},
{
"id": "split_0_train_45372_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
53,
56
]
],
"normalized": []
},
{
"id": "split_0_train_45373_entity",
"type": "progene_text",
"text": [
"p50(csk)"
],
"offsets": [
[
96,
104
]
],
"normalized": []
},
{
"id": "split_0_train_45374_entity",
"type": "progene_text",
"text": [
"FN"
],
"offsets": [
[
141,
143
]
],
"normalized": []
},
{
"id": "split_0_train_45375_entity",
"type": "progene_text",
"text": [
"Src-family PTKs"
],
"offsets": [
[
160,
175
]
],
"normalized": []
},
{
"id": "split_0_train_45376_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
200,
203
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28014
|
split_0_train_28014
|
[
{
"id": "split_0_train_28014_passage",
"type": "progene_text",
"text": [
"Expression of the FAK C - terminal domain , FRNK , promoted FAK dephosphorylation at Tyr-397 and potently blocked FAK - mediated cell migration ."
],
"offsets": [
[
0,
145
]
]
}
] |
[
{
"id": "split_0_train_45377_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
18,
21
]
],
"normalized": []
},
{
"id": "split_0_train_45378_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
60,
63
]
],
"normalized": []
},
{
"id": "split_0_train_45379_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
114,
117
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28015
|
split_0_train_28015
|
[
{
"id": "split_0_train_28015_passage",
"type": "progene_text",
"text": [
"This dominant - negative effect of FRNK was reversed by a point mutation ( Leu - 1034 to Ser ) which prevented FRNK localization to focal contact sites ."
],
"offsets": [
[
0,
153
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28016
|
split_0_train_28016
|
[
{
"id": "split_0_train_28016_passage",
"type": "progene_text",
"text": [
"Our results show that FAK functions as a key regulator of fibronectin receptor stimulated cell migration events through the recruitment of both SH2 and SH3 domain - containing signaling proteins to sites of integrin receptor clustering ."
],
"offsets": [
[
0,
237
]
]
}
] |
[
{
"id": "split_0_train_45380_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
22,
25
]
],
"normalized": []
},
{
"id": "split_0_train_45381_entity",
"type": "progene_text",
"text": [
"fibronectin receptor"
],
"offsets": [
[
58,
78
]
],
"normalized": []
},
{
"id": "split_0_train_45382_entity",
"type": "progene_text",
"text": [
"integrin"
],
"offsets": [
[
207,
215
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28017
|
split_0_train_28017
|
[
{
"id": "split_0_train_28017_passage",
"type": "progene_text",
"text": [
"Molecular determinants of the interaction between the C - terminal domain of Alzheimer 's beta-amyloid peptide and apolipoprotein E alpha - helices ."
],
"offsets": [
[
0,
149
]
]
}
] |
[
{
"id": "split_0_train_45383_entity",
"type": "progene_text",
"text": [
"beta-amyloid peptide"
],
"offsets": [
[
90,
110
]
],
"normalized": []
},
{
"id": "split_0_train_45384_entity",
"type": "progene_text",
"text": [
"apolipoprotein E"
],
"offsets": [
[
115,
131
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28018
|
split_0_train_28018
|
[
{
"id": "split_0_train_28018_passage",
"type": "progene_text",
"text": [
"In a previous work , we predicted and demonstrated that the 29-42-residue fragment of beta-amyloid peptide ( Abeta peptide ) has in vitro capacities close to those of the tilted fragment of viral fusion proteins ."
],
"offsets": [
[
0,
213
]
]
}
] |
[
{
"id": "split_0_train_45385_entity",
"type": "progene_text",
"text": [
"beta-amyloid peptide"
],
"offsets": [
[
86,
106
]
],
"normalized": []
},
{
"id": "split_0_train_45386_entity",
"type": "progene_text",
"text": [
"Abeta peptide"
],
"offsets": [
[
109,
122
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28019
|
split_0_train_28019
|
[
{
"id": "split_0_train_28019_passage",
"type": "progene_text",
"text": [
"We further demonstrated that apolipoprotein E2 and E3 but not apolipoprotein E4 can decrease the fusogenic activity of Abeta ( 29-42 ) via a direct interaction ."
],
"offsets": [
[
0,
161
]
]
}
] |
[
{
"id": "split_0_train_45387_entity",
"type": "progene_text",
"text": [
"apolipoprotein E2"
],
"offsets": [
[
29,
46
]
],
"normalized": []
},
{
"id": "split_0_train_45388_entity",
"type": "progene_text",
"text": [
"apolipoprotein E4"
],
"offsets": [
[
62,
79
]
],
"normalized": []
},
{
"id": "split_0_train_45389_entity",
"type": "progene_text",
"text": [
"Abeta"
],
"offsets": [
[
119,
124
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28020
|
split_0_train_28020
|
[
{
"id": "split_0_train_28020_passage",
"type": "progene_text",
"text": [
"Therefore , we suggested that this fragment is implicated in the neurotoxicity of Abeta and in the protective effects of apolipoprotein E in Alzheimer 's disease ."
],
"offsets": [
[
0,
163
]
]
}
] |
[
{
"id": "split_0_train_45390_entity",
"type": "progene_text",
"text": [
"Abeta"
],
"offsets": [
[
82,
87
]
],
"normalized": []
},
{
"id": "split_0_train_45391_entity",
"type": "progene_text",
"text": [
"apolipoprotein E"
],
"offsets": [
[
121,
137
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28021
|
split_0_train_28021
|
[
{
"id": "split_0_train_28021_passage",
"type": "progene_text",
"text": [
"Because structurally related apolipoproteins do not interact with the Abeta C - terminal domain but inhibit viral fusion , we suggested that interactions existing between fusogenic peptides and apolipoproteins are selective and responsible for the inhibition of fusion ."
],
"offsets": [
[
0,
270
]
]
}
] |
[
{
"id": "split_0_train_45392_entity",
"type": "progene_text",
"text": [
"apolipoproteins"
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29,
44
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{
"id": "split_0_train_45393_entity",
"type": "progene_text",
"text": [
"Abeta"
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70,
75
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},
{
"id": "split_0_train_45394_entity",
"type": "progene_text",
"text": [
"apolipoproteins"
],
"offsets": [
[
194,
209
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28022
|
split_0_train_28022
|
[
{
"id": "split_0_train_28022_passage",
"type": "progene_text",
"text": [
"In this study , we simulated interactions of all amphipathic helices of apolipoproteins E and A-I with Abeta and simian immunodeficiency virus ( SIV ) fusogenic fragments by molecular modeling ."
],
"offsets": [
[
0,
194
]
]
}
] |
[
{
"id": "split_0_train_45395_entity",
"type": "progene_text",
"text": [
"apolipoproteins E and A-I"
],
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[
72,
97
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],
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},
{
"id": "split_0_train_45396_entity",
"type": "progene_text",
"text": [
"Abeta"
],
"offsets": [
[
103,
108
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28023
|
split_0_train_28023
|
[
{
"id": "split_0_train_28023_passage",
"type": "progene_text",
"text": [
"We further calculated cross - interactions that do not inhibit fusion in vitro ."
],
"offsets": [
[
0,
80
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28024
|
split_0_train_28024
|
[
{
"id": "split_0_train_28024_passage",
"type": "progene_text",
"text": [
"The results suggest that interactions of hydrophobic residues are the major event to inhibit the fusogenic capacities of Abeta ( 29-42 ) and SIV peptides ."
],
"offsets": [
[
0,
155
]
]
}
] |
[
{
"id": "split_0_train_45397_entity",
"type": "progene_text",
"text": [
"Abeta"
],
"offsets": [
[
121,
126
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28025
|
split_0_train_28025
|
[
{
"id": "split_0_train_28025_passage",
"type": "progene_text",
"text": [
"Selectivity of those interactions is due to the steric complementarity between bulky hydrophobic residues in the fusogenic fragments and hydrophobic residues in the apolipoprotein C - terminal amphipathic helices ."
],
"offsets": [
[
0,
214
]
]
}
] |
[
{
"id": "split_0_train_45398_entity",
"type": "progene_text",
"text": [
"apolipoprotein C"
],
"offsets": [
[
165,
181
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28026
|
split_0_train_28026
|
[
{
"id": "split_0_train_28026_passage",
"type": "progene_text",
"text": [
"Repair of endonuclease - induced double - strand breaks in Saccharomyces cerevisiae : essential role for genes associated with nonhomologous end - joining ."
],
"offsets": [
[
0,
156
]
]
}
] |
[
{
"id": "split_0_train_45399_entity",
"type": "progene_text",
"text": [
"endonuclease"
],
"offsets": [
[
10,
22
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28027
|
split_0_train_28027
|
[
{
"id": "split_0_train_28027_passage",
"type": "progene_text",
"text": [
"Repair of double - strand breaks ( DSBs ) in chromosomal DNA by nonhomologous end - joining ( NHEJ ) is not well characterized in the yeast Saccharomyces cerevisiae ."
],
"offsets": [
[
0,
166
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28028
|
split_0_train_28028
|
[
{
"id": "split_0_train_28028_passage",
"type": "progene_text",
"text": [
"Here we demonstrate that several genes associated with NHEJ perform essential functions in the repair of endonuclease - induced DSBs in vivo ."
],
"offsets": [
[
0,
142
]
]
}
] |
[
{
"id": "split_0_train_45400_entity",
"type": "progene_text",
"text": [
"endonuclease"
],
"offsets": [
[
105,
117
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28029
|
split_0_train_28029
|
[
{
"id": "split_0_train_28029_passage",
"type": "progene_text",
"text": [
"Galactose - induced expression of EcoRI endonuclease in rad50 , mre11 , or xrs2 mutants , which are deficient in plasmid DSB end - joining and some forms of recombination , resulted in G2 arrest and rapid cell killing ."
],
"offsets": [
[
0,
219
]
]
}
] |
[
{
"id": "split_0_train_45401_entity",
"type": "progene_text",
"text": [
"EcoRI"
],
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[
34,
39
]
],
"normalized": []
},
{
"id": "split_0_train_45402_entity",
"type": "progene_text",
"text": [
"endonuclease"
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"offsets": [
[
40,
52
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],
"normalized": []
},
{
"id": "split_0_train_45403_entity",
"type": "progene_text",
"text": [
"rad50"
],
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[
56,
61
]
],
"normalized": []
},
{
"id": "split_0_train_45404_entity",
"type": "progene_text",
"text": [
"mre11"
],
"offsets": [
[
64,
69
]
],
"normalized": []
},
{
"id": "split_0_train_45405_entity",
"type": "progene_text",
"text": [
"xrs2"
],
"offsets": [
[
75,
79
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28030
|
split_0_train_28030
|
[
{
"id": "split_0_train_28030_passage",
"type": "progene_text",
"text": [
"Endonuclease synthesis also produced moderate cell killing in sir4 strains ."
],
"offsets": [
[
0,
76
]
]
}
] |
[
{
"id": "split_0_train_45406_entity",
"type": "progene_text",
"text": [
"Endonuclease"
],
"offsets": [
[
0,
12
]
],
"normalized": []
},
{
"id": "split_0_train_45407_entity",
"type": "progene_text",
"text": [
"sir4"
],
"offsets": [
[
62,
66
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28031
|
split_0_train_28031
|
[
{
"id": "split_0_train_28031_passage",
"type": "progene_text",
"text": [
"In contrast , EcoRI caused prolonged cell - cycle arrest of recombination - defective rad51 , rad52 , rad54 , rad55 , and rad57 mutants , but cells remained viable ."
],
"offsets": [
[
0,
165
]
]
}
] |
[
{
"id": "split_0_train_45408_entity",
"type": "progene_text",
"text": [
"EcoRI"
],
"offsets": [
[
14,
19
]
],
"normalized": []
},
{
"id": "split_0_train_45409_entity",
"type": "progene_text",
"text": [
"rad51"
],
"offsets": [
[
86,
91
]
],
"normalized": []
},
{
"id": "split_0_train_45410_entity",
"type": "progene_text",
"text": [
"rad52"
],
"offsets": [
[
94,
99
]
],
"normalized": []
},
{
"id": "split_0_train_45411_entity",
"type": "progene_text",
"text": [
"rad54"
],
"offsets": [
[
102,
107
]
],
"normalized": []
},
{
"id": "split_0_train_45412_entity",
"type": "progene_text",
"text": [
"rad55"
],
"offsets": [
[
110,
115
]
],
"normalized": []
},
{
"id": "split_0_train_45413_entity",
"type": "progene_text",
"text": [
"rad57"
],
"offsets": [
[
122,
127
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28032
|
split_0_train_28032
|
[
{
"id": "split_0_train_28032_passage",
"type": "progene_text",
"text": [
"Cell - cycle progression was inhibited in excision repair - defective rad1 mutants , but not in rad2 cells , indicating a role for Rad1 processing of the DSB ends ."
],
"offsets": [
[
0,
164
]
]
}
] |
[
{
"id": "split_0_train_45414_entity",
"type": "progene_text",
"text": [
"rad1"
],
"offsets": [
[
70,
74
]
],
"normalized": []
},
{
"id": "split_0_train_45415_entity",
"type": "progene_text",
"text": [
"rad2"
],
"offsets": [
[
96,
100
]
],
"normalized": []
},
{
"id": "split_0_train_45416_entity",
"type": "progene_text",
"text": [
"Rad1"
],
"offsets": [
[
131,
135
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28033
|
split_0_train_28033
|
[
{
"id": "split_0_train_28033_passage",
"type": "progene_text",
"text": [
"Phenotypic responses of additional mutants , including exo1 , srs2 , rad5 , and rdh54 strains , suggest roles in recombinational repair , but not in NHEJ ."
],
"offsets": [
[
0,
155
]
]
}
] |
[
{
"id": "split_0_train_45417_entity",
"type": "progene_text",
"text": [
"exo1"
],
"offsets": [
[
55,
59
]
],
"normalized": []
},
{
"id": "split_0_train_45418_entity",
"type": "progene_text",
"text": [
"srs2"
],
"offsets": [
[
62,
66
]
],
"normalized": []
},
{
"id": "split_0_train_45419_entity",
"type": "progene_text",
"text": [
"rad5"
],
"offsets": [
[
69,
73
]
],
"normalized": []
},
{
"id": "split_0_train_45420_entity",
"type": "progene_text",
"text": [
"rdh54"
],
"offsets": [
[
80,
85
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28034
|
split_0_train_28034
|
[
{
"id": "split_0_train_28034_passage",
"type": "progene_text",
"text": [
"Interestingly , the rapid cell killing in haploid rad50 and mre11 strains was largely eliminated in diploids , suggesting that the cohesive - ended DSBs could be efficiently repaired by homologous recombination throughout the cell cycle in the diploid mutants ."
],
"offsets": [
[
0,
261
]
]
}
] |
[
{
"id": "split_0_train_45421_entity",
"type": "progene_text",
"text": [
"rad50"
],
"offsets": [
[
50,
55
]
],
"normalized": []
},
{
"id": "split_0_train_45422_entity",
"type": "progene_text",
"text": [
"mre11"
],
"offsets": [
[
60,
65
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28035
|
split_0_train_28035
|
[
{
"id": "split_0_train_28035_passage",
"type": "progene_text",
"text": [
"These results demonstrate essential but separable roles for NHEJ pathway genes in the repair of chromosomal DSBs that are structurally similar to those occurring during cellular development ."
],
"offsets": [
[
0,
191
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28036
|
split_0_train_28036
|
[
{
"id": "split_0_train_28036_passage",
"type": "progene_text",
"text": [
"Expression of tumour necrosis factor receptors ( CD120a and CD120b ) on bronchoalveolar cells ."
],
"offsets": [
[
0,
95
]
]
}
] |
[
{
"id": "split_0_train_45423_entity",
"type": "progene_text",
"text": [
"tumour necrosis factor receptors"
],
"offsets": [
[
14,
46
]
],
"normalized": []
},
{
"id": "split_0_train_45424_entity",
"type": "progene_text",
"text": [
"CD120a"
],
"offsets": [
[
49,
55
]
],
"normalized": []
},
{
"id": "split_0_train_45425_entity",
"type": "progene_text",
"text": [
"CD120b"
],
"offsets": [
[
60,
66
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28037
|
split_0_train_28037
|
[
{
"id": "split_0_train_28037_passage",
"type": "progene_text",
"text": [
"It is generally accepted that physiological modulators for tumour necrosis factor ( TNF ) are present in a variety of body fluids including serum ."
],
"offsets": [
[
0,
147
]
]
}
] |
[
{
"id": "split_0_train_45426_entity",
"type": "progene_text",
"text": [
"tumour necrosis factor"
],
"offsets": [
[
59,
81
]
],
"normalized": []
},
{
"id": "split_0_train_45427_entity",
"type": "progene_text",
"text": [
"TNF"
],
"offsets": [
[
84,
87
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28038
|
split_0_train_28038
|
[
{
"id": "split_0_train_28038_passage",
"type": "progene_text",
"text": [
"Among these modulators are soluble TNF receptors ( TNF-R ) that are cleaved from the extracellular domain of the TNF-Rs ."
],
"offsets": [
[
0,
121
]
]
}
] |
[
{
"id": "split_0_train_45428_entity",
"type": "progene_text",
"text": [
"TNF receptors"
],
"offsets": [
[
35,
48
]
],
"normalized": []
},
{
"id": "split_0_train_45429_entity",
"type": "progene_text",
"text": [
"TNF-R"
],
"offsets": [
[
51,
56
]
],
"normalized": []
},
{
"id": "split_0_train_45430_entity",
"type": "progene_text",
"text": [
"TNF-Rs"
],
"offsets": [
[
113,
119
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28039
|
split_0_train_28039
|
[
{
"id": "split_0_train_28039_passage",
"type": "progene_text",
"text": [
"Two receptors of different structures with molecular weights of 55 kDa ( CD120a ) and 75 kDa ( CD120b ) are known to be expressed on monocytes , lymphocytes , granulocytes and other cells of peripheral blood ."
],
"offsets": [
[
0,
209
]
]
}
] |
[
{
"id": "split_0_train_45431_entity",
"type": "progene_text",
"text": [
"CD120a"
],
"offsets": [
[
73,
79
]
],
"normalized": []
},
{
"id": "split_0_train_45432_entity",
"type": "progene_text",
"text": [
"CD120b"
],
"offsets": [
[
95,
101
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28040
|
split_0_train_28040
|
[
{
"id": "split_0_train_28040_passage",
"type": "progene_text",
"text": [
"The aim of our study was to determine the expression of CD120a and CD120b on bronchoalveolar lavage cells ( BAL cells ) ."
],
"offsets": [
[
0,
121
]
]
}
] |
[
{
"id": "split_0_train_45433_entity",
"type": "progene_text",
"text": [
"CD120a"
],
"offsets": [
[
56,
62
]
],
"normalized": []
},
{
"id": "split_0_train_45434_entity",
"type": "progene_text",
"text": [
"CD120b"
],
"offsets": [
[
67,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28041
|
split_0_train_28041
|
[
{
"id": "split_0_train_28041_passage",
"type": "progene_text",
"text": [
"BAL cells of 14 patients with different pulmonary disorders were stained with anti - CD120a and anti - CD120b monoclonal antibodies and were differentiated by FACS analysis ."
],
"offsets": [
[
0,
174
]
]
}
] |
[
{
"id": "split_0_train_45435_entity",
"type": "progene_text",
"text": [
"CD120a"
],
"offsets": [
[
85,
91
]
],
"normalized": []
},
{
"id": "split_0_train_45436_entity",
"type": "progene_text",
"text": [
"CD120b"
],
"offsets": [
[
103,
109
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28042
|
split_0_train_28042
|
[
{
"id": "split_0_train_28042_passage",
"type": "progene_text",
"text": [
"Both TNF-Rs are expressed on monocytes , macrophages , lymphocytes and granulocytes of the BAL ."
],
"offsets": [
[
0,
96
]
]
}
] |
[
{
"id": "split_0_train_45437_entity",
"type": "progene_text",
"text": [
"TNF-Rs"
],
"offsets": [
[
5,
11
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28043
|
split_0_train_28043
|
[
{
"id": "split_0_train_28043_passage",
"type": "progene_text",
"text": [
"Although the relation of CD120a to CD120b is individual for a given cell type and an individual patient , strict correlations between both receptors were observed for BAL monocytes and alveolar macrophages ."
],
"offsets": [
[
0,
207
]
]
}
] |
[
{
"id": "split_0_train_45438_entity",
"type": "progene_text",
"text": [
"CD120a"
],
"offsets": [
[
25,
31
]
],
"normalized": []
},
{
"id": "split_0_train_45439_entity",
"type": "progene_text",
"text": [
"CD120b"
],
"offsets": [
[
35,
41
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28044
|
split_0_train_28044
|
[
{
"id": "split_0_train_28044_passage",
"type": "progene_text",
"text": [
"CD120a are expressed on 29.7 % of alveolar macrophages ; similar data were obtained for CD120b ."
],
"offsets": [
[
0,
96
]
]
}
] |
[
{
"id": "split_0_train_45440_entity",
"type": "progene_text",
"text": [
"CD120a"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "split_0_train_45441_entity",
"type": "progene_text",
"text": [
"CD120b"
],
"offsets": [
[
88,
94
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28045
|
split_0_train_28045
|
[
{
"id": "split_0_train_28045_passage",
"type": "progene_text",
"text": [
"24.3 % of the BAL monocytes were positive for CD120a and 25.5 % for CD120b ."
],
"offsets": [
[
0,
76
]
]
}
] |
[
{
"id": "split_0_train_45442_entity",
"type": "progene_text",
"text": [
"CD120a"
],
"offsets": [
[
46,
52
]
],
"normalized": []
},
{
"id": "split_0_train_45443_entity",
"type": "progene_text",
"text": [
"CD120b"
],
"offsets": [
[
68,
74
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28046
|
split_0_train_28046
|
[
{
"id": "split_0_train_28046_passage",
"type": "progene_text",
"text": [
"4.1 % of the BAL lymphocytes were positive for CD120a whereas the percentage of CD120b positive BAL lymphocytes was approximately six times greater ."
],
"offsets": [
[
0,
149
]
]
}
] |
[
{
"id": "split_0_train_45444_entity",
"type": "progene_text",
"text": [
"CD120a"
],
"offsets": [
[
47,
53
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"type": "progene_text",
"text": [
"CD120b"
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[
80,
86
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],
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}
] |
[] |
[] |
[] |
split_0_train_28047
|
split_0_train_28047
|
[
{
"id": "split_0_train_28047_passage",
"type": "progene_text",
"text": [
"Analysis of BAL granulocytes revealed 21.2 % cells positive for CD120a and 11.6 % for CD120b ."
],
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[
0,
94
]
]
}
] |
[
{
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"CD120a"
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64,
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"type": "progene_text",
"text": [
"CD120b"
],
"offsets": [
[
86,
92
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28048
|
split_0_train_28048
|
[
{
"id": "split_0_train_28048_passage",
"type": "progene_text",
"text": [
"In contrast to the BAL cells named above there was no positive correlation between CD120a and CD120b expression on BAL lymphocytes and granulocytes ."
],
"offsets": [
[
0,
149
]
]
}
] |
[
{
"id": "split_0_train_45448_entity",
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83,
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"type": "progene_text",
"text": [
"CD120b"
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"offsets": [
[
94,
100
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28049
|
split_0_train_28049
|
[
{
"id": "split_0_train_28049_passage",
"type": "progene_text",
"text": [
"We were able to show that TNF-Rs of BAL cells , like those of blood cells , are shedded in vitro after incubation with or without lipopolysaccharide ( LPS ) , detected as TNFalpha - inhibitor activity in cell culture supernatant ."
],
"offsets": [
[
0,
230
]
]
}
] |
[
{
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"TNF-Rs"
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26,
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"type": "progene_text",
"text": [
"TNFalpha"
],
"offsets": [
[
171,
179
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28050
|
split_0_train_28050
|
[
{
"id": "split_0_train_28050_passage",
"type": "progene_text",
"text": [
"In conclusion , BAL cells express and shed TNF-Rs , as is known for cells of other body compartments ."
],
"offsets": [
[
0,
102
]
]
}
] |
[
{
"id": "split_0_train_45452_entity",
"type": "progene_text",
"text": [
"TNF-Rs"
],
"offsets": [
[
43,
49
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28051
|
split_0_train_28051
|
[
{
"id": "split_0_train_28051_passage",
"type": "progene_text",
"text": [
"The B cell antigen receptor activates the Akt ( protein kinase B ) / glycogen synthase kinase-3 signaling pathway via phosphatidylinositol 3-kinase ."
],
"offsets": [
[
0,
149
]
]
}
] |
[
{
"id": "split_0_train_45453_entity",
"type": "progene_text",
"text": [
"B cell antigen receptor"
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4,
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"id": "split_0_train_45454_entity",
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"text": [
"Akt"
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42,
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"id": "split_0_train_45455_entity",
"type": "progene_text",
"text": [
"protein kinase B"
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48,
64
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{
"id": "split_0_train_45456_entity",
"type": "progene_text",
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69,
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},
{
"id": "split_0_train_45457_entity",
"type": "progene_text",
"text": [
"phosphatidylinositol 3-kinase"
],
"offsets": [
[
118,
147
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28052
|
split_0_train_28052
|
[
{
"id": "split_0_train_28052_passage",
"type": "progene_text",
"text": [
"We have previously shown that the B cell Ag receptor ( BCR ) activates phosphatidylinositol ( PI ) 3-kinase ."
],
"offsets": [
[
0,
109
]
]
}
] |
[
{
"id": "split_0_train_45458_entity",
"type": "progene_text",
"text": [
"B cell Ag receptor"
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[
34,
52
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{
"id": "split_0_train_45459_entity",
"type": "progene_text",
"text": [
"BCR"
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55,
58
]
],
"normalized": []
},
{
"id": "split_0_train_45460_entity",
"type": "progene_text",
"text": [
"phosphatidylinositol ( PI ) 3-kinase"
],
"offsets": [
[
71,
107
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28053
|
split_0_train_28053
|
[
{
"id": "split_0_train_28053_passage",
"type": "progene_text",
"text": [
"We now show that a serine / threonine kinase called Akt or protein kinase B is a downstream target of PI 3-kinase in B cells ."
],
"offsets": [
[
0,
126
]
]
}
] |
[
{
"id": "split_0_train_45461_entity",
"type": "progene_text",
"text": [
"serine / threonine kinase"
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[
19,
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},
{
"id": "split_0_train_45462_entity",
"type": "progene_text",
"text": [
"Akt"
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[
52,
55
]
],
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},
{
"id": "split_0_train_45463_entity",
"type": "progene_text",
"text": [
"protein kinase B"
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59,
75
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],
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},
{
"id": "split_0_train_45464_entity",
"type": "progene_text",
"text": [
"PI 3-kinase"
],
"offsets": [
[
102,
113
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28054
|
split_0_train_28054
|
[
{
"id": "split_0_train_28054_passage",
"type": "progene_text",
"text": [
"Akt has been shown to promote cell survival as well as the transcription and translation of proteins involved in cell cycle progression ."
],
"offsets": [
[
0,
137
]
]
}
] |
[
{
"id": "split_0_train_45465_entity",
"type": "progene_text",
"text": [
"Akt"
],
"offsets": [
[
0,
3
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28055
|
split_0_train_28055
|
[
{
"id": "split_0_train_28055_passage",
"type": "progene_text",
"text": [
"Using an Ab that specifically recognizes the activated form of Akt that is phosphorylated on serine 473 , we show that BCR engagement activates Akt in a PI 3-kinase - dependent manner ."
],
"offsets": [
[
0,
185
]
]
}
] |
[
{
"id": "split_0_train_45466_entity",
"type": "progene_text",
"text": [
"Ab"
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[
9,
11
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{
"id": "split_0_train_45467_entity",
"type": "progene_text",
"text": [
"Akt"
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63,
66
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],
"normalized": []
},
{
"id": "split_0_train_45468_entity",
"type": "progene_text",
"text": [
"BCR"
],
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119,
122
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],
"normalized": []
},
{
"id": "split_0_train_45469_entity",
"type": "progene_text",
"text": [
"Akt"
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[
144,
147
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],
"normalized": []
},
{
"id": "split_0_train_45470_entity",
"type": "progene_text",
"text": [
"PI 3-kinase"
],
"offsets": [
[
153,
164
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28056
|
split_0_train_28056
|
[
{
"id": "split_0_train_28056_passage",
"type": "progene_text",
"text": [
"These results were confirmed using in vitro kinase assays ."
],
"offsets": [
[
0,
59
]
]
}
] |
[
{
"id": "split_0_train_45471_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
44,
50
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28057
|
split_0_train_28057
|
[
{
"id": "split_0_train_28057_passage",
"type": "progene_text",
"text": [
"Moreover , BCR ligation also induced phosphorylation of Akt of threonine 308 , another modification that is required for activation of Akt ."
],
"offsets": [
[
0,
140
]
]
}
] |
[
{
"id": "split_0_train_45472_entity",
"type": "progene_text",
"text": [
"BCR"
],
"offsets": [
[
11,
14
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],
"normalized": []
},
{
"id": "split_0_train_45473_entity",
"type": "progene_text",
"text": [
"Akt"
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"offsets": [
[
56,
59
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],
"normalized": []
},
{
"id": "split_0_train_45474_entity",
"type": "progene_text",
"text": [
"Akt"
],
"offsets": [
[
135,
138
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28058
|
split_0_train_28058
|
[
{
"id": "split_0_train_28058_passage",
"type": "progene_text",
"text": [
"In the DT40 chicken B cell line , phosphorylation of Akt on serine 473 was completely dependent on the Lyn tyrosine kinase , while the Syk tyrosine kinase was required for sustained phosphorylation of Akt ."
],
"offsets": [
[
0,
206
]
]
}
] |
[
{
"id": "split_0_train_45475_entity",
"type": "progene_text",
"text": [
"Akt"
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"offsets": [
[
53,
56
]
],
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},
{
"id": "split_0_train_45476_entity",
"type": "progene_text",
"text": [
"Lyn"
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[
103,
106
]
],
"normalized": []
},
{
"id": "split_0_train_45477_entity",
"type": "progene_text",
"text": [
"tyrosine kinase"
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[
107,
122
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],
"normalized": []
},
{
"id": "split_0_train_45478_entity",
"type": "progene_text",
"text": [
"Syk"
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"offsets": [
[
135,
138
]
],
"normalized": []
},
{
"id": "split_0_train_45479_entity",
"type": "progene_text",
"text": [
"tyrosine kinase"
],
"offsets": [
[
139,
154
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],
"normalized": []
},
{
"id": "split_0_train_45480_entity",
"type": "progene_text",
"text": [
"Akt"
],
"offsets": [
[
201,
204
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28059
|
split_0_train_28059
|
[
{
"id": "split_0_train_28059_passage",
"type": "progene_text",
"text": [
"Complementary experiments in BCR - expressing AtT20 endocrine cells confirmed that Src kinases are sufficient for BCR - induced Akt phosphorylation , but that Syk is required for sustained phosphorylation of Akt on both serine 473 and threonine 308 ."
],
"offsets": [
[
0,
250
]
]
}
] |
[
{
"id": "split_0_train_45481_entity",
"type": "progene_text",
"text": [
"BCR"
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[
29,
32
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},
{
"id": "split_0_train_45482_entity",
"type": "progene_text",
"text": [
"Src"
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83,
86
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],
"normalized": []
},
{
"id": "split_0_train_45483_entity",
"type": "progene_text",
"text": [
"kinases"
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87,
94
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],
"normalized": []
},
{
"id": "split_0_train_45484_entity",
"type": "progene_text",
"text": [
"BCR"
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[
114,
117
]
],
"normalized": []
},
{
"id": "split_0_train_45485_entity",
"type": "progene_text",
"text": [
"Akt"
],
"offsets": [
[
128,
131
]
],
"normalized": []
},
{
"id": "split_0_train_45486_entity",
"type": "progene_text",
"text": [
"Syk"
],
"offsets": [
[
159,
162
]
],
"normalized": []
},
{
"id": "split_0_train_45487_entity",
"type": "progene_text",
"text": [
"Akt"
],
"offsets": [
[
208,
211
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28060
|
split_0_train_28060
|
[
{
"id": "split_0_train_28060_passage",
"type": "progene_text",
"text": [
"In insulin - responsive cells , Akt phosphorylates and inactivates the serine / threonine kinase glycogen synthase kinase-3 ( GSK-3 ) ."
],
"offsets": [
[
0,
135
]
]
}
] |
[
{
"id": "split_0_train_45488_entity",
"type": "progene_text",
"text": [
"insulin"
],
"offsets": [
[
3,
10
]
],
"normalized": []
},
{
"id": "split_0_train_45489_entity",
"type": "progene_text",
"text": [
"Akt"
],
"offsets": [
[
32,
35
]
],
"normalized": []
},
{
"id": "split_0_train_45490_entity",
"type": "progene_text",
"text": [
"serine / threonine kinase"
],
"offsets": [
[
71,
96
]
],
"normalized": []
},
{
"id": "split_0_train_45491_entity",
"type": "progene_text",
"text": [
"glycogen synthase kinase-3"
],
"offsets": [
[
97,
123
]
],
"normalized": []
},
{
"id": "split_0_train_45492_entity",
"type": "progene_text",
"text": [
"GSK-3"
],
"offsets": [
[
126,
131
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28061
|
split_0_train_28061
|
[
{
"id": "split_0_train_28061_passage",
"type": "progene_text",
"text": [
"Inactivation of GSK-3 may promote nuclear accumulation of several transcription factors , including NF-ATc ."
],
"offsets": [
[
0,
108
]
]
}
] |
[
{
"id": "split_0_train_45493_entity",
"type": "progene_text",
"text": [
"GSK-3"
],
"offsets": [
[
16,
21
]
],
"normalized": []
},
{
"id": "split_0_train_45494_entity",
"type": "progene_text",
"text": [
"transcription factors"
],
"offsets": [
[
66,
87
]
],
"normalized": []
},
{
"id": "split_0_train_45495_entity",
"type": "progene_text",
"text": [
"NF-ATc"
],
"offsets": [
[
100,
106
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28062
|
split_0_train_28062
|
[
{
"id": "split_0_train_28062_passage",
"type": "progene_text",
"text": [
"We found that BCR engagement induced GSK-3 phosphorylation and decreased GSK-3 enzyme activity ."
],
"offsets": [
[
0,
96
]
]
}
] |
[
{
"id": "split_0_train_45496_entity",
"type": "progene_text",
"text": [
"BCR"
],
"offsets": [
[
14,
17
]
],
"normalized": []
},
{
"id": "split_0_train_45497_entity",
"type": "progene_text",
"text": [
"GSK-3"
],
"offsets": [
[
37,
42
]
],
"normalized": []
},
{
"id": "split_0_train_45498_entity",
"type": "progene_text",
"text": [
"GSK-3"
],
"offsets": [
[
73,
78
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28063
|
split_0_train_28063
|
[
{
"id": "split_0_train_28063_passage",
"type": "progene_text",
"text": [
"Thus , BCR ligation initiates a PI 3-kinase / Akt / GSK-3 signaling pathway ."
],
"offsets": [
[
0,
77
]
]
}
] |
[
{
"id": "split_0_train_45499_entity",
"type": "progene_text",
"text": [
"BCR"
],
"offsets": [
[
7,
10
]
],
"normalized": []
},
{
"id": "split_0_train_45500_entity",
"type": "progene_text",
"text": [
"PI 3-kinase"
],
"offsets": [
[
32,
43
]
],
"normalized": []
},
{
"id": "split_0_train_45501_entity",
"type": "progene_text",
"text": [
"Akt"
],
"offsets": [
[
46,
49
]
],
"normalized": []
},
{
"id": "split_0_train_45502_entity",
"type": "progene_text",
"text": [
"GSK-3"
],
"offsets": [
[
52,
57
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28064
|
split_0_train_28064
|
[
{
"id": "split_0_train_28064_passage",
"type": "progene_text",
"text": [
"Binge drinking and bone metabolism in a young actively growing rat model ."
],
"offsets": [
[
0,
74
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28065
|
split_0_train_28065
|
[
{
"id": "split_0_train_28065_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28066
|
split_0_train_28066
|
[
{
"id": "split_0_train_28066_passage",
"type": "progene_text",
"text": [
"Chronic alcohol consumption has been demonstrated to be deleterious to bone health ."
],
"offsets": [
[
0,
84
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28067
|
split_0_train_28067
|
[
{
"id": "split_0_train_28067_passage",
"type": "progene_text",
"text": [
"However , binge drinking is the prevalent form of drinking in young people , which was the impetus for the present study to determine the effect of week - end and week - long binge drinking on bone health in a young actively growing animal model ."
],
"offsets": [
[
0,
247
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28068
|
split_0_train_28068
|
[
{
"id": "split_0_train_28068_passage",
"type": "progene_text",
"text": [
"METHODS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28069
|
split_0_train_28069
|
[
{
"id": "split_0_train_28069_passage",
"type": "progene_text",
"text": [
"Four - week - old , female , Sprague - Dawley rats were given the amount of 5 % alcohol by gavage to be equivalent to a 63 kg woman drinking six beers a day for either 2 or 5 consecutive days per week ."
],
"offsets": [
[
0,
202
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28070
|
split_0_train_28070
|
[
{
"id": "split_0_train_28070_passage",
"type": "progene_text",
"text": [
"RESULTS :"
],
"offsets": [
[
0,
9
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28071
|
split_0_train_28071
|
[
{
"id": "split_0_train_28071_passage",
"type": "progene_text",
"text": [
"There were no changes in the 5 - day binge animals , but the 2 - day binge animals were hypocalcemic ."
],
"offsets": [
[
0,
102
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28072
|
split_0_train_28072
|
[
{
"id": "split_0_train_28072_passage",
"type": "progene_text",
"text": [
"Similarly , 2 - day binge animals had slightly increased bone chemistry and histomorphometric values for both tibia and femur , but only femur length , dry weight , and ash weight as well as femur density , presented either as g / ml or ash weight per unit volume , were increased by a statistically significant level ."
],
"offsets": [
[
0,
319
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28073
|
split_0_train_28073
|
[
{
"id": "split_0_train_28073_passage",
"type": "progene_text",
"text": [
"Cross - section periosteal Mineral Apposition Rate ( MAR ) was significantly decreased in the 2 - day alcohol fed animals ."
],
"offsets": [
[
0,
123
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28074
|
split_0_train_28074
|
[
{
"id": "split_0_train_28074_passage",
"type": "progene_text",
"text": [
"CONCLUSIONS :"
],
"offsets": [
[
0,
13
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28075
|
split_0_train_28075
|
[
{
"id": "split_0_train_28075_passage",
"type": "progene_text",
"text": [
"Actively growing rats given 5 % alcohol by gavage for 2 days per week have an increased bone length , bone weight , and bone density ."
],
"offsets": [
[
0,
134
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28076
|
split_0_train_28076
|
[
{
"id": "split_0_train_28076_passage",
"type": "progene_text",
"text": [
"The interpretation of these results must be viewed with great caution because studies of chronic alcohol consumption , and many studies of acute drinking , clearly indicate deleterious effects of alcohol on bone health ."
],
"offsets": [
[
0,
220
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28077
|
split_0_train_28077
|
[
{
"id": "split_0_train_28077_passage",
"type": "progene_text",
"text": [
"Those fed alcohol for 5 days per week showed no change ."
],
"offsets": [
[
0,
56
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28078
|
split_0_train_28078
|
[
{
"id": "split_0_train_28078_passage",
"type": "progene_text",
"text": [
"Activator protein-2 mediates transcriptional activation of the CYP11A1 gene by interaction with Sp1 rather than binding to DNA ."
],
"offsets": [
[
0,
128
]
]
}
] |
[
{
"id": "split_0_train_45503_entity",
"type": "progene_text",
"text": [
"Activator protein-2"
],
"offsets": [
[
0,
19
]
],
"normalized": []
},
{
"id": "split_0_train_45504_entity",
"type": "progene_text",
"text": [
"CYP11A1"
],
"offsets": [
[
63,
70
]
],
"normalized": []
},
{
"id": "split_0_train_45505_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
96,
99
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28079
|
split_0_train_28079
|
[
{
"id": "split_0_train_28079_passage",
"type": "progene_text",
"text": [
"The ovine P45 side chain cleavage ( CYP11A1 ) enzyme gene , which catalyzes the initial enzymatic step in steroid hormone biosynthesis is transcriptionally regulated in cultured steroidogenic human trophoblastic JEG-3 cells ."
],
"offsets": [
[
0,
225
]
]
}
] |
[
{
"id": "split_0_train_45506_entity",
"type": "progene_text",
"text": [
"P45 side chain cleavage"
],
"offsets": [
[
10,
33
]
],
"normalized": []
},
{
"id": "split_0_train_45507_entity",
"type": "progene_text",
"text": [
"CYP11A1"
],
"offsets": [
[
36,
43
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28080
|
split_0_train_28080
|
[
{
"id": "split_0_train_28080_passage",
"type": "progene_text",
"text": [
"The ovine CYP11A1 promoter contains two GC - rich footprinted regions referred to as ovine footprints 5 ( OF5 ) and OF3 , which are well conserved among the CYP11A1 promoters of different species ."
],
"offsets": [
[
0,
197
]
]
}
] |
[
{
"id": "split_0_train_45508_entity",
"type": "progene_text",
"text": [
"CYP11A1"
],
"offsets": [
[
10,
17
]
],
"normalized": []
},
{
"id": "split_0_train_45509_entity",
"type": "progene_text",
"text": [
"CYP11A1"
],
"offsets": [
[
157,
164
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28081
|
split_0_train_28081
|
[
{
"id": "split_0_train_28081_passage",
"type": "progene_text",
"text": [
"These GC - rich sequences resemble activator protein-2 ( AP-2 ) / Sp1 binding sites and were previously implicated in basal and cAMP - regulated activity of the bovine and ovine CYP11A1 promoters ."
],
"offsets": [
[
0,
197
]
]
}
] |
[
{
"id": "split_0_train_45510_entity",
"type": "progene_text",
"text": [
"activator protein-2"
],
"offsets": [
[
35,
54
]
],
"normalized": []
},
{
"id": "split_0_train_45511_entity",
"type": "progene_text",
"text": [
"AP-2"
],
"offsets": [
[
57,
61
]
],
"normalized": []
},
{
"id": "split_0_train_45512_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
66,
69
]
],
"normalized": []
},
{
"id": "split_0_train_45513_entity",
"type": "progene_text",
"text": [
"CYP11A1"
],
"offsets": [
[
178,
185
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28082
|
split_0_train_28082
|
[
{
"id": "split_0_train_28082_passage",
"type": "progene_text",
"text": [
"In the current studies , AP-2 induced the ovine CYP11A1 promoter 4.5 - fold in JEG-3 cells with full induction requiring the previously defined cAMP - responsive elements ."
],
"offsets": [
[
0,
172
]
]
}
] |
[
{
"id": "split_0_train_45514_entity",
"type": "progene_text",
"text": [
"AP-2"
],
"offsets": [
[
25,
29
]
],
"normalized": []
},
{
"id": "split_0_train_45515_entity",
"type": "progene_text",
"text": [
"CYP11A1"
],
"offsets": [
[
48,
55
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28083
|
split_0_train_28083
|
[
{
"id": "split_0_train_28083_passage",
"type": "progene_text",
"text": [
"Point mutation of OF3 abolished induction by AP-2 , and OF3 was sufficient for induction by AP-2 when linked to a heterologous promoter ."
],
"offsets": [
[
0,
137
]
]
}
] |
[
{
"id": "split_0_train_45516_entity",
"type": "progene_text",
"text": [
"AP-2"
],
"offsets": [
[
45,
49
]
],
"normalized": []
},
{
"id": "split_0_train_45517_entity",
"type": "progene_text",
"text": [
"AP-2"
],
"offsets": [
[
92,
96
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28084
|
split_0_train_28084
|
[
{
"id": "split_0_train_28084_passage",
"type": "progene_text",
"text": [
"AP-2 induction of the CYP11A1 promoter required the basic region ( N165 - N278 ) and the carboxy terminus of AP-2 ( N413-N437 ) ."
],
"offsets": [
[
0,
129
]
]
}
] |
[
{
"id": "split_0_train_45518_entity",
"type": "progene_text",
"text": [
"AP-2"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_45519_entity",
"type": "progene_text",
"text": [
"CYP11A1"
],
"offsets": [
[
22,
29
]
],
"normalized": []
},
{
"id": "split_0_train_45520_entity",
"type": "progene_text",
"text": [
"AP-2"
],
"offsets": [
[
109,
113
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28085
|
split_0_train_28085
|
[
{
"id": "split_0_train_28085_passage",
"type": "progene_text",
"text": [
"In the course of investigating the mechanisms by which OF5 and OF3 regulated CYP11A1 transcription , we found that OF5 and OF3 bound Sp1 and Sp3 in JEG-3 cells ."
],
"offsets": [
[
0,
161
]
]
}
] |
[
{
"id": "split_0_train_45521_entity",
"type": "progene_text",
"text": [
"CYP11A1"
],
"offsets": [
[
77,
84
]
],
"normalized": []
},
{
"id": "split_0_train_45522_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
133,
136
]
],
"normalized": []
},
{
"id": "split_0_train_45523_entity",
"type": "progene_text",
"text": [
"Sp3"
],
"offsets": [
[
141,
144
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28086
|
split_0_train_28086
|
[
{
"id": "split_0_train_28086_passage",
"type": "progene_text",
"text": [
"AP-2 did not bind OF5 or OF3 directly but rather formed a multiprotein complex with Sp1 in JEG-3 cells ."
],
"offsets": [
[
0,
104
]
]
}
] |
[
{
"id": "split_0_train_45524_entity",
"type": "progene_text",
"text": [
"AP-2"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_45525_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
84,
87
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28087
|
split_0_train_28087
|
[
{
"id": "split_0_train_28087_passage",
"type": "progene_text",
"text": [
"AP-2 associated directly with Sp1 in vitro requiring the AP-2 basic region and the Sp1 carboxy terminus ."
],
"offsets": [
[
0,
105
]
]
}
] |
[
{
"id": "split_0_train_45526_entity",
"type": "progene_text",
"text": [
"AP-2"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_45527_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
30,
33
]
],
"normalized": []
},
{
"id": "split_0_train_45528_entity",
"type": "progene_text",
"text": [
"AP-2"
],
"offsets": [
[
57,
61
]
],
"normalized": []
},
{
"id": "split_0_train_45529_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
83,
86
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28088
|
split_0_train_28088
|
[
{
"id": "split_0_train_28088_passage",
"type": "progene_text",
"text": [
"AP-2 induced Sp1 / Sp3 activity independently of AP-2 binding to DNA using a GAL4 paradigm ."
],
"offsets": [
[
0,
92
]
]
}
] |
[
{
"id": "split_0_train_45530_entity",
"type": "progene_text",
"text": [
"AP-2"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_45531_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
13,
16
]
],
"normalized": []
},
{
"id": "split_0_train_45532_entity",
"type": "progene_text",
"text": [
"Sp3"
],
"offsets": [
[
19,
22
]
],
"normalized": []
},
{
"id": "split_0_train_45533_entity",
"type": "progene_text",
"text": [
"AP-2"
],
"offsets": [
[
49,
53
]
],
"normalized": []
},
{
"id": "split_0_train_45534_entity",
"type": "progene_text",
"text": [
"GAL4"
],
"offsets": [
[
77,
81
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28089
|
split_0_train_28089
|
[
{
"id": "split_0_train_28089_passage",
"type": "progene_text",
"text": [
"The Sp1 and Sp3 transactivation domains were linked to the DNA - binding domain of GAL4 , and their activity was assessed using a luciferase reporter gene containing only the GAL4 DNA - binding sites linked to the minimal TATA site ."
],
"offsets": [
[
0,
233
]
]
}
] |
[
{
"id": "split_0_train_45535_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
4,
7
]
],
"normalized": []
},
{
"id": "split_0_train_45536_entity",
"type": "progene_text",
"text": [
"Sp3"
],
"offsets": [
[
12,
15
]
],
"normalized": []
},
{
"id": "split_0_train_45537_entity",
"type": "progene_text",
"text": [
"GAL4"
],
"offsets": [
[
83,
87
]
],
"normalized": []
},
{
"id": "split_0_train_45538_entity",
"type": "progene_text",
"text": [
"luciferase"
],
"offsets": [
[
130,
140
]
],
"normalized": []
},
{
"id": "split_0_train_45539_entity",
"type": "progene_text",
"text": [
"GAL4"
],
"offsets": [
[
175,
179
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28090
|
split_0_train_28090
|
[
{
"id": "split_0_train_28090_passage",
"type": "progene_text",
"text": [
"AP-2 induced Sp1 / Sp3 - GAL4 activity 3 - to 4 - fold , requiring both the amino and extreme carboxy terminus of AP-2 ."
],
"offsets": [
[
0,
120
]
]
}
] |
[
{
"id": "split_0_train_45540_entity",
"type": "progene_text",
"text": [
"AP-2"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_45541_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
13,
16
]
],
"normalized": []
},
{
"id": "split_0_train_45542_entity",
"type": "progene_text",
"text": [
"Sp3"
],
"offsets": [
[
19,
22
]
],
"normalized": []
},
{
"id": "split_0_train_45543_entity",
"type": "progene_text",
"text": [
"GAL4"
],
"offsets": [
[
25,
29
]
],
"normalized": []
},
{
"id": "split_0_train_45544_entity",
"type": "progene_text",
"text": [
"AP-2"
],
"offsets": [
[
114,
118
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28091
|
split_0_train_28091
|
[
{
"id": "split_0_train_28091_passage",
"type": "progene_text",
"text": [
"We conclude that AP-2 can bind to and stimulate Sp1 activity and induces the ovine CYP11A1 promoter through conserved Sp1 / Sp3 - binding sites in JEG-3 cells ."
],
"offsets": [
[
0,
160
]
]
}
] |
[
{
"id": "split_0_train_45545_entity",
"type": "progene_text",
"text": [
"AP-2"
],
"offsets": [
[
17,
21
]
],
"normalized": []
},
{
"id": "split_0_train_45546_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
48,
51
]
],
"normalized": []
},
{
"id": "split_0_train_45547_entity",
"type": "progene_text",
"text": [
"CYP11A1"
],
"offsets": [
[
83,
90
]
],
"normalized": []
},
{
"id": "split_0_train_45548_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
118,
121
]
],
"normalized": []
},
{
"id": "split_0_train_45549_entity",
"type": "progene_text",
"text": [
"Sp3"
],
"offsets": [
[
124,
127
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28092
|
split_0_train_28092
|
[
{
"id": "split_0_train_28092_passage",
"type": "progene_text",
"text": [
"The induction of Sp1 activity by AP-2 may contribute to the induction of other genes that bind Sp1 ."
],
"offsets": [
[
0,
100
]
]
}
] |
[
{
"id": "split_0_train_45550_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
17,
20
]
],
"normalized": []
},
{
"id": "split_0_train_45551_entity",
"type": "progene_text",
"text": [
"AP-2"
],
"offsets": [
[
33,
37
]
],
"normalized": []
},
{
"id": "split_0_train_45552_entity",
"type": "progene_text",
"text": [
"Sp1"
],
"offsets": [
[
95,
98
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28093
|
split_0_train_28093
|
[
{
"id": "split_0_train_28093_passage",
"type": "progene_text",
"text": [
"Tobacco smoking and supragingival dental calculus ."
],
"offsets": [
[
0,
51
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28094
|
split_0_train_28094
|
[
{
"id": "split_0_train_28094_passage",
"type": "progene_text",
"text": [
"Supragingival calculus is frequent in all ages from adolescence to old age ."
],
"offsets": [
[
0,
76
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28095
|
split_0_train_28095
|
[
{
"id": "split_0_train_28095_passage",
"type": "progene_text",
"text": [
"The influence of tobacco smoking on the occurrence and severity of supragingival calculus has received surprisingly little attention ."
],
"offsets": [
[
0,
134
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28096
|
split_0_train_28096
|
[
{
"id": "split_0_train_28096_passage",
"type": "progene_text",
"text": [
"The present investigation conducted in a population of 258 dentally aware individuals in the age range 20 - 69 years , was initiated to elucidate the relationship between tobacco smoking and supragingival calculus , taking into account possible confounding factors such as age , gender , oral hygiene and gingival inflammation ."
],
"offsets": [
[
0,
328
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28097
|
split_0_train_28097
|
[
{
"id": "split_0_train_28097_passage",
"type": "progene_text",
"text": [
"The calculus deposition was bilaterally assessed on the lingual surfaces of the mandibular anteriors and the vestibular surfaces of the maxillary premolars and molars ."
],
"offsets": [
[
0,
168
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28098
|
split_0_train_28098
|
[
{
"id": "split_0_train_28098_passage",
"type": "progene_text",
"text": [
"The overall prevalence of supragingival calculus was 69 % ranging from 59 % in age group 20 - 34 years to 84 % in age group 50 - 69 years ."
],
"offsets": [
[
0,
139
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28099
|
split_0_train_28099
|
[
{
"id": "split_0_train_28099_passage",
"type": "progene_text",
"text": [
"The prevalence rates for current smokers , former smokers , and nonsmokers were 86 % , 66 % , and 65 % ."
],
"offsets": [
[
0,
104
]
]
}
] |
[] |
[] |
[] |
[] |
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