id
stringlengths 15
19
| document_id
stringlengths 15
19
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
split_0_train_28200
|
split_0_train_28200
|
[
{
"id": "split_0_train_28200_passage",
"type": "progene_text",
"text": [
"Identification of XDRP1 ; a Xenopus protein related to yeast Dsk2p binds to the N-terminus of cyclin A and inhibits its degradation ."
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "split_0_train_45702_entity",
"type": "progene_text",
"text": [
"XDRP1"
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18,
23
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{
"id": "split_0_train_45703_entity",
"type": "progene_text",
"text": [
"Dsk2p"
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61,
66
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{
"id": "split_0_train_45704_entity",
"type": "progene_text",
"text": [
"cyclin A"
],
"offsets": [
[
94,
102
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28201
|
split_0_train_28201
|
[
{
"id": "split_0_train_28201_passage",
"type": "progene_text",
"text": [
"Using the N - terminus of cyclin A1 in a two - hybrid screen as a bait , we identified a Xenopus protein , XDRP1 , that contains a ubiquitin - like domain in its N-terminus and shows significant homology in its C-terminal 50 residues to Saccharomyces cerevisiae Dsk2 and Schizosaccharomyces pombe dph1 ."
],
"offsets": [
[
0,
303
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]
}
] |
[
{
"id": "split_0_train_45705_entity",
"type": "progene_text",
"text": [
"cyclin A1"
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26,
35
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{
"id": "split_0_train_45706_entity",
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"text": [
"XDRP1"
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107,
112
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{
"id": "split_0_train_45707_entity",
"type": "progene_text",
"text": [
"ubiquitin"
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131,
140
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},
{
"id": "split_0_train_45708_entity",
"type": "progene_text",
"text": [
"Dsk2"
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[
262,
266
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],
"normalized": []
},
{
"id": "split_0_train_45709_entity",
"type": "progene_text",
"text": [
"dph1"
],
"offsets": [
[
297,
301
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28202
|
split_0_train_28202
|
[
{
"id": "split_0_train_28202_passage",
"type": "progene_text",
"text": [
"XDRP1 is a nuclear phosphoprotein in Xenopus cells , and its phosphorylation is mediated by cyclin A - dependent kinase ."
],
"offsets": [
[
0,
121
]
]
}
] |
[
{
"id": "split_0_train_45710_entity",
"type": "progene_text",
"text": [
"XDRP1"
],
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[
0,
5
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],
"normalized": []
},
{
"id": "split_0_train_45711_entity",
"type": "progene_text",
"text": [
"cyclin A"
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[
92,
100
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],
"normalized": []
},
{
"id": "split_0_train_45712_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
113,
119
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28203
|
split_0_train_28203
|
[
{
"id": "split_0_train_28203_passage",
"type": "progene_text",
"text": [
"XDRP1 binds to both embryonic and somatic forms of cyclin A ( A1 and A2 ) in Xenopus cells , but not to B - type cyclins ."
],
"offsets": [
[
0,
122
]
]
}
] |
[
{
"id": "split_0_train_45713_entity",
"type": "progene_text",
"text": [
"XDRP1"
],
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[
0,
5
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"normalized": []
},
{
"id": "split_0_train_45714_entity",
"type": "progene_text",
"text": [
"cyclin A"
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[
51,
59
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],
"normalized": []
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{
"id": "split_0_train_45715_entity",
"type": "progene_text",
"text": [
"B - type cyclins"
],
"offsets": [
[
104,
120
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28204
|
split_0_train_28204
|
[
{
"id": "split_0_train_28204_passage",
"type": "progene_text",
"text": [
"The N - terminal ubiquitin - like domain of XDRP1 , but not the C - terminal Dsk2 - like domain , is required for interaction with cyclin A ."
],
"offsets": [
[
0,
141
]
]
}
] |
[
{
"id": "split_0_train_45716_entity",
"type": "progene_text",
"text": [
"ubiquitin"
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"offsets": [
[
17,
26
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],
"normalized": []
},
{
"id": "split_0_train_45717_entity",
"type": "progene_text",
"text": [
"XDRP1"
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[
44,
49
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],
"normalized": []
},
{
"id": "split_0_train_45718_entity",
"type": "progene_text",
"text": [
"Dsk2"
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"offsets": [
[
77,
81
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],
"normalized": []
},
{
"id": "split_0_train_45719_entity",
"type": "progene_text",
"text": [
"cyclin A"
],
"offsets": [
[
131,
139
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28205
|
split_0_train_28205
|
[
{
"id": "split_0_train_28205_passage",
"type": "progene_text",
"text": [
"XDRP1 requires residues 130 - 160 of cyclin A1 for efficient binding , which do not include the destruction box of cyclin A ."
],
"offsets": [
[
0,
125
]
]
}
] |
[
{
"id": "split_0_train_45720_entity",
"type": "progene_text",
"text": [
"XDRP1"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "split_0_train_45721_entity",
"type": "progene_text",
"text": [
"cyclin A1"
],
"offsets": [
[
37,
46
]
],
"normalized": []
},
{
"id": "split_0_train_45722_entity",
"type": "progene_text",
"text": [
"cyclin A"
],
"offsets": [
[
115,
123
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28206
|
split_0_train_28206
|
[
{
"id": "split_0_train_28206_passage",
"type": "progene_text",
"text": [
"The addition of bacterially expressed XDRP1 protein to frog egg extract inhibited the Ca(2+) - induced degradation of cyclin A , but not that of cyclin B ."
],
"offsets": [
[
0,
155
]
]
}
] |
[
{
"id": "split_0_train_45723_entity",
"type": "progene_text",
"text": [
"XDRP1"
],
"offsets": [
[
38,
43
]
],
"normalized": []
},
{
"id": "split_0_train_45724_entity",
"type": "progene_text",
"text": [
"cyclin A"
],
"offsets": [
[
118,
126
]
],
"normalized": []
},
{
"id": "split_0_train_45725_entity",
"type": "progene_text",
"text": [
"cyclin B"
],
"offsets": [
[
145,
153
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28207
|
split_0_train_28207
|
[
{
"id": "split_0_train_28207_passage",
"type": "progene_text",
"text": [
"The injection of XDRP1 protein into fertilized Xenopus eggs blocked embryonic cell division ."
],
"offsets": [
[
0,
93
]
]
}
] |
[
{
"id": "split_0_train_45726_entity",
"type": "progene_text",
"text": [
"XDRP1"
],
"offsets": [
[
17,
22
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28208
|
split_0_train_28208
|
[
{
"id": "split_0_train_28208_passage",
"type": "progene_text",
"text": [
"ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB ."
],
"offsets": [
[
0,
142
]
]
}
] |
[
{
"id": "split_0_train_45727_entity",
"type": "progene_text",
"text": [
"ERK MAP kinase"
],
"offsets": [
[
0,
14
]
],
"normalized": []
},
{
"id": "split_0_train_45728_entity",
"type": "progene_text",
"text": [
"cytokine"
],
"offsets": [
[
21,
29
]
],
"normalized": []
},
{
"id": "split_0_train_45729_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
122,
126
]
],
"normalized": []
},
{
"id": "split_0_train_45730_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
131,
140
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28209
|
split_0_train_28209
|
[
{
"id": "split_0_train_28209_passage",
"type": "progene_text",
"text": [
"Human immunodeficiency virus type 1 ( HIV-1 ) can establish latent infection following provirus integration into the host genome ."
],
"offsets": [
[
0,
130
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28210
|
split_0_train_28210
|
[
{
"id": "split_0_train_28210_passage",
"type": "progene_text",
"text": [
"NF-kappaB plays a critical role in activation of HIV-1 gene expression by cytokines and other stimuli , but the signal transduction pathways that regulate the switch from latent to productive infection have not been defined ."
],
"offsets": [
[
0,
225
]
]
}
] |
[
{
"id": "split_0_train_45731_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "split_0_train_45732_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
74,
83
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28211
|
split_0_train_28211
|
[
{
"id": "split_0_train_28211_passage",
"type": "progene_text",
"text": [
"Here , we show that ERK1 / ERK2 mitogen - activated protein kinase ( MAPK ) plays a central role in linking signals at the cell surface to activation of HIV-1 gene expression in latently infected cells ."
],
"offsets": [
[
0,
203
]
]
}
] |
[
{
"id": "split_0_train_45733_entity",
"type": "progene_text",
"text": [
"ERK1"
],
"offsets": [
[
20,
24
]
],
"normalized": []
},
{
"id": "split_0_train_45734_entity",
"type": "progene_text",
"text": [
"ERK2"
],
"offsets": [
[
27,
31
]
],
"normalized": []
},
{
"id": "split_0_train_45735_entity",
"type": "progene_text",
"text": [
"mitogen - activated protein kinase"
],
"offsets": [
[
32,
66
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],
"normalized": []
},
{
"id": "split_0_train_45736_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
69,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28212
|
split_0_train_28212
|
[
{
"id": "split_0_train_28212_passage",
"type": "progene_text",
"text": [
"MAPK was activated by cytokines and phorbol 12-myristate 13-acetate in latently infected U1 cells ."
],
"offsets": [
[
0,
99
]
]
}
] |
[
{
"id": "split_0_train_45737_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "split_0_train_45738_entity",
"type": "progene_text",
"text": [
"cytokines"
],
"offsets": [
[
22,
31
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28213
|
split_0_train_28213
|
[
{
"id": "split_0_train_28213_passage",
"type": "progene_text",
"text": [
"The induction of HIV-1 expression by these stimuli was inhibited by PD98059 and U0126 , which are specific inhibitors of MAPK activation ."
],
"offsets": [
[
0,
138
]
]
}
] |
[
{
"id": "split_0_train_45739_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
121,
125
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28214
|
split_0_train_28214
|
[
{
"id": "split_0_train_28214_passage",
"type": "progene_text",
"text": [
"Studies using constitutively active MEK or Raf kinase mutants demonstrated that MAPK activates the HIV-1 long terminal repeat ( LTR ) through the NF-kappaB sites ."
],
"offsets": [
[
0,
163
]
]
}
] |
[
{
"id": "split_0_train_45740_entity",
"type": "progene_text",
"text": [
"MEK"
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"offsets": [
[
36,
39
]
],
"normalized": []
},
{
"id": "split_0_train_45741_entity",
"type": "progene_text",
"text": [
"Raf kinase"
],
"offsets": [
[
43,
53
]
],
"normalized": []
},
{
"id": "split_0_train_45742_entity",
"type": "progene_text",
"text": [
"MAPK"
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[
80,
84
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],
"normalized": []
},
{
"id": "split_0_train_45743_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
146,
155
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28215
|
split_0_train_28215
|
[
{
"id": "split_0_train_28215_passage",
"type": "progene_text",
"text": [
"Most HIV-1 inducers activated NF-kappaB via a MAPK - independent pathway , indicating that activation of NF-kappaB is not sufficient to explain the activation of HIV-1 gene expression by MAPK ."
],
"offsets": [
[
0,
193
]
]
}
] |
[
{
"id": "split_0_train_45744_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
30,
39
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],
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},
{
"id": "split_0_train_45745_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
46,
50
]
],
"normalized": []
},
{
"id": "split_0_train_45746_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
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[
105,
114
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],
"normalized": []
},
{
"id": "split_0_train_45747_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
187,
191
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28216
|
split_0_train_28216
|
[
{
"id": "split_0_train_28216_passage",
"type": "progene_text",
"text": [
"In contrast , all of the stimuli activated AP-1 via a MAPK - dependent pathway ."
],
"offsets": [
[
0,
80
]
]
}
] |
[
{
"id": "split_0_train_45748_entity",
"type": "progene_text",
"text": [
"AP-1"
],
"offsets": [
[
43,
47
]
],
"normalized": []
},
{
"id": "split_0_train_45749_entity",
"type": "progene_text",
"text": [
"MAPK"
],
"offsets": [
[
54,
58
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28217
|
split_0_train_28217
|
[
{
"id": "split_0_train_28217_passage",
"type": "progene_text",
"text": [
"NF-kappaB and AP-1 components c-Fos and c-Jun were shown to physically associate by yeast two - hybrid assays and electrophoretic mobility shift assays ."
],
"offsets": [
[
0,
153
]
]
}
] |
[
{
"id": "split_0_train_45750_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
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[
0,
9
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],
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},
{
"id": "split_0_train_45751_entity",
"type": "progene_text",
"text": [
"AP-1"
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[
14,
18
]
],
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},
{
"id": "split_0_train_45752_entity",
"type": "progene_text",
"text": [
"c-Fos"
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[
30,
35
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],
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},
{
"id": "split_0_train_45753_entity",
"type": "progene_text",
"text": [
"c-Jun"
],
"offsets": [
[
40,
45
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28218
|
split_0_train_28218
|
[
{
"id": "split_0_train_28218_passage",
"type": "progene_text",
"text": [
"Coexpression of NF-kappaB and c-Fos or c-Jun synergistically transactivated the HIV-1 LTR through the NF-kappaB sites ."
],
"offsets": [
[
0,
119
]
]
}
] |
[
{
"id": "split_0_train_45754_entity",
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"text": [
"NF-kappaB"
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[
16,
25
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],
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},
{
"id": "split_0_train_45755_entity",
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"text": [
"c-Fos"
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[
30,
35
]
],
"normalized": []
},
{
"id": "split_0_train_45756_entity",
"type": "progene_text",
"text": [
"c-Jun"
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39,
44
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],
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},
{
"id": "split_0_train_45757_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
102,
111
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28219
|
split_0_train_28219
|
[
{
"id": "split_0_train_28219_passage",
"type": "progene_text",
"text": [
"These studies suggest that MAPK acts by stimulating AP-1 and a subsequent physical and functional interaction of AP-1 with NF-kappaB , resulting in a complex that synergistically transactivates the HIV-1 LTR ."
],
"offsets": [
[
0,
209
]
]
}
] |
[
{
"id": "split_0_train_45758_entity",
"type": "progene_text",
"text": [
"MAPK"
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"offsets": [
[
27,
31
]
],
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},
{
"id": "split_0_train_45759_entity",
"type": "progene_text",
"text": [
"AP-1"
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[
52,
56
]
],
"normalized": []
},
{
"id": "split_0_train_45760_entity",
"type": "progene_text",
"text": [
"AP-1"
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[
113,
117
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],
"normalized": []
},
{
"id": "split_0_train_45761_entity",
"type": "progene_text",
"text": [
"NF-kappaB"
],
"offsets": [
[
123,
132
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28220
|
split_0_train_28220
|
[
{
"id": "split_0_train_28220_passage",
"type": "progene_text",
"text": [
"These results define a mechanism for signal - dependent activation of HIV-1 replication in latently infected cells and suggest potential therapeutic strategies for unmasking latent reservoirs of HIV-1 ."
],
"offsets": [
[
0,
202
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28221
|
split_0_train_28221
|
[
{
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"text": [
"Ras - GTPase activating protein inhibition specifically induces apoptosis of tumour cells ."
],
"offsets": [
[
0,
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]
}
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[
{
"id": "split_0_train_45762_entity",
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"text": [
"Ras - GTPase activating protein"
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"offsets": [
[
0,
31
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}
] |
[] |
[] |
[] |
split_0_train_28222
|
split_0_train_28222
|
[
{
"id": "split_0_train_28222_passage",
"type": "progene_text",
"text": [
"Oncogenes and tumour suppressor genes control the balance between apoptotic death and anti - apoptotic survival signals determining whether a cell proliferates or dies ."
],
"offsets": [
[
0,
169
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28223
|
split_0_train_28223
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[
{
"id": "split_0_train_28223_passage",
"type": "progene_text",
"text": [
"Through which effectors might oncoproteins generate sensitivity to apoptosis remains to be determined ."
],
"offsets": [
[
0,
103
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28224
|
split_0_train_28224
|
[
{
"id": "split_0_train_28224_passage",
"type": "progene_text",
"text": [
"Ras GTPase activating protein ( Ras-GAP ) is a key element in the Ras signalling pathway , being both a negative regulator and possibly an effector of Ras ."
],
"offsets": [
[
0,
156
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]
}
] |
[
{
"id": "split_0_train_45763_entity",
"type": "progene_text",
"text": [
"Ras GTPase activating protein"
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[
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66,
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"type": "progene_text",
"text": [
"Ras"
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"offsets": [
[
151,
154
]
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"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28225
|
split_0_train_28225
|
[
{
"id": "split_0_train_28225_passage",
"type": "progene_text",
"text": [
"Ras-GAP acts as a regulator of transcription , and possibly connects Ras to stress - activated protein kinases ."
],
"offsets": [
[
0,
112
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]
}
] |
[
{
"id": "split_0_train_45767_entity",
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"Ras-GAP"
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{
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"text": [
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{
"id": "split_0_train_45769_entity",
"type": "progene_text",
"text": [
"stress - activated protein kinases"
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"offsets": [
[
76,
110
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28226
|
split_0_train_28226
|
[
{
"id": "split_0_train_28226_passage",
"type": "progene_text",
"text": [
"A role for Ras-GAP in cell survival has been suspected from the study of knock - out mouse embryos ."
],
"offsets": [
[
0,
100
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]
}
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[
{
"id": "split_0_train_45770_entity",
"type": "progene_text",
"text": [
"Ras-GAP"
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"offsets": [
[
11,
18
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28227
|
split_0_train_28227
|
[
{
"id": "split_0_train_28227_passage",
"type": "progene_text",
"text": [
"In search for selective killing of tumour cells , we asked whether Ras - GAP inhibition by other means would lead to apoptosis in established cell lines ."
],
"offsets": [
[
0,
154
]
]
}
] |
[
{
"id": "split_0_train_45771_entity",
"type": "progene_text",
"text": [
"Ras - GAP"
],
"offsets": [
[
67,
76
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28228
|
split_0_train_28228
|
[
{
"id": "split_0_train_28228_passage",
"type": "progene_text",
"text": [
"We injected a monoclonal antibody directed against the SH3 domain of Ras-GAP ( mAb200 ) that has been shown to block Ras-GAP downstream signalling into various human normal and tumour cell lines ."
],
"offsets": [
[
0,
196
]
]
}
] |
[
{
"id": "split_0_train_45772_entity",
"type": "progene_text",
"text": [
"Ras-GAP"
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"offsets": [
[
69,
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"normalized": []
},
{
"id": "split_0_train_45773_entity",
"type": "progene_text",
"text": [
"Ras-GAP"
],
"offsets": [
[
117,
124
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28229
|
split_0_train_28229
|
[
{
"id": "split_0_train_28229_passage",
"type": "progene_text",
"text": [
"We show that inhibition of Ras-GAP induces apoptosis specifically in tumour , but not in normal cells , therefore pointing at a specific role for Ras-GAP in tumour cell survival ."
],
"offsets": [
[
0,
179
]
]
}
] |
[
{
"id": "split_0_train_45774_entity",
"type": "progene_text",
"text": [
"Ras-GAP"
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"offsets": [
[
27,
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"normalized": []
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{
"id": "split_0_train_45775_entity",
"type": "progene_text",
"text": [
"Ras-GAP"
],
"offsets": [
[
146,
153
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28230
|
split_0_train_28230
|
[
{
"id": "split_0_train_28230_passage",
"type": "progene_text",
"text": [
"MAb200 - induced apoptosis is largely prevented by coinjection of activated RhoA or Cdc42 proteins , by injection of a constitutively activated mutant of phosphoinositide 3-OH kinase ( PI3-K ) , but not by injection of v-Raf ."
],
"offsets": [
[
0,
226
]
]
}
] |
[
{
"id": "split_0_train_45776_entity",
"type": "progene_text",
"text": [
"RhoA"
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[
76,
80
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"normalized": []
},
{
"id": "split_0_train_45777_entity",
"type": "progene_text",
"text": [
"Cdc42"
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"offsets": [
[
84,
89
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],
"normalized": []
},
{
"id": "split_0_train_45778_entity",
"type": "progene_text",
"text": [
"phosphoinositide 3-OH kinase"
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"offsets": [
[
154,
182
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],
"normalized": []
},
{
"id": "split_0_train_45779_entity",
"type": "progene_text",
"text": [
"PI3-K"
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"offsets": [
[
185,
190
]
],
"normalized": []
},
{
"id": "split_0_train_45780_entity",
"type": "progene_text",
"text": [
"v-Raf"
],
"offsets": [
[
219,
224
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28231
|
split_0_train_28231
|
[
{
"id": "split_0_train_28231_passage",
"type": "progene_text",
"text": [
"These results show that targeting of Ras-GAP could represent a novel anticancer approach ."
],
"offsets": [
[
0,
90
]
]
}
] |
[
{
"id": "split_0_train_45781_entity",
"type": "progene_text",
"text": [
"Ras-GAP"
],
"offsets": [
[
37,
44
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28232
|
split_0_train_28232
|
[
{
"id": "split_0_train_28232_passage",
"type": "progene_text",
"text": [
"Mutations in the C , D , and V open reading frames of human parainfluenza virus type 3 attenuate replication in rodents and primates ."
],
"offsets": [
[
0,
134
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28233
|
split_0_train_28233
|
[
{
"id": "split_0_train_28233_passage",
"type": "progene_text",
"text": [
"Human parainfluenza virus type 3 ( HPIV3 ) is a single - stranded negative - sense RNA virus belonging to the Respirovirus genus of the Paramyxoviridae family in the order Mononegavirales ."
],
"offsets": [
[
0,
189
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28234
|
split_0_train_28234
|
[
{
"id": "split_0_train_28234_passage",
"type": "progene_text",
"text": [
"The P gene encodes at least four proteins , including the C protein , which is expressed from an open reading frame ( ORF ) that overlaps the P ORF , and the D protein , which is encoded when the P ORF is fused to the D ORF by transcriptional editing ."
],
"offsets": [
[
0,
252
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28235
|
split_0_train_28235
|
[
{
"id": "split_0_train_28235_passage",
"type": "progene_text",
"text": [
"The P mRNA also contains a third ORF for the V protein , although it is unclear how or whether this ORF is accessed ."
],
"offsets": [
[
0,
117
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28236
|
split_0_train_28236
|
[
{
"id": "split_0_train_28236_passage",
"type": "progene_text",
"text": [
"We have used recombinant DNA technology to recover five mutant viruses that either interrupt or alter the C , D , and V ORFs ."
],
"offsets": [
[
0,
126
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28237
|
split_0_train_28237
|
[
{
"id": "split_0_train_28237_passage",
"type": "progene_text",
"text": [
"In one mutant virus , rC-KO , expression of the C protein was abrogated by changing the start codon from methionine to threonine and introducing two stop codons at amino acid positions 7 and 26 of the C ORF ."
],
"offsets": [
[
0,
208
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28238
|
split_0_train_28238
|
[
{
"id": "split_0_train_28238_passage",
"type": "progene_text",
"text": [
"In a second mutant virus , rF164S , a point mutation was introduced into the C ORF changing amino acid position 164 from phenylalanine ( F ) to serine ( S ) , which corresponds to the F170S mutation described in the C protein of Sendai virus ( Itoh et al. , J. Gen. Virol. 78 , 3207 - 3215 ) ."
],
"offsets": [
[
0,
293
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28239
|
split_0_train_28239
|
[
{
"id": "split_0_train_28239_passage",
"type": "progene_text",
"text": [
"rC-KO was significantly attenuated in vitro and in vivo ( rodents and primates ) , whereas rF164S was attenuated only in vivo ."
],
"offsets": [
[
0,
127
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28240
|
split_0_train_28240
|
[
{
"id": "split_0_train_28240_passage",
"type": "progene_text",
"text": [
"Interestingly , the rF164S mutant was more attenuated in the upper than in the lower respiratory tract of hamsters and monkeys ."
],
"offsets": [
[
0,
128
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28241
|
split_0_train_28241
|
[
{
"id": "split_0_train_28241_passage",
"type": "progene_text",
"text": [
"This pattern is the converse of that seen with temperature - sensitive attenuating mutations , and thus inclusion of this novel mutation in a recombinant live - attenuated vaccine candidate might prove useful in reducing residual virulence in the upper respiratory tract ."
],
"offsets": [
[
0,
272
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28242
|
split_0_train_28242
|
[
{
"id": "split_0_train_28242_passage",
"type": "progene_text",
"text": [
"Both rC-KO and rF164S conferred protection against challenge with wild - type HPIV3 ."
],
"offsets": [
[
0,
85
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28243
|
split_0_train_28243
|
[
{
"id": "split_0_train_28243_passage",
"type": "progene_text",
"text": [
"In three other viruses , the D and V ORFs were interrupted singly or in combination ."
],
"offsets": [
[
0,
85
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28244
|
split_0_train_28244
|
[
{
"id": "split_0_train_28244_passage",
"type": "progene_text",
"text": [
"Although interruption of the D and V ORFs individually did not affect virus replication in vitro or in vivo , interruption of both together attenuated replication in vivo ."
],
"offsets": [
[
0,
172
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28245
|
split_0_train_28245
|
[
{
"id": "split_0_train_28245_passage",
"type": "progene_text",
"text": [
"These results indicate that the C , D , and V proteins of HPIV3 each has a role in virus replication in vitro , in vivo , or both , and define mutations that might be useful for the development of a vaccine against HPIV3 ."
],
"offsets": [
[
0,
222
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28246
|
split_0_train_28246
|
[
{
"id": "split_0_train_28246_passage",
"type": "progene_text",
"text": [
"A clinical trial of the ReSound IC4 hearing device ."
],
"offsets": [
[
0,
52
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28247
|
split_0_train_28247
|
[
{
"id": "split_0_train_28247_passage",
"type": "progene_text",
"text": [
"A manufacturer - sponsored clinical trial was conducted of ReSound Corporation 's IC4 hearing device ( HD ) , an in-the-ear application of their two - channel , fast - acting , wide - dynamic range compression sound processor ."
],
"offsets": [
[
0,
227
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28248
|
split_0_train_28248
|
[
{
"id": "split_0_train_28248_passage",
"type": "progene_text",
"text": [
"This study was a follow - up to an earlier clinical trial of ReSound 's behind-the-ear version of the same sound processor , the BT2 Personal Hearing System ( Walden , B. E. , Surr , R. K. , Cord , M. T. , & Pavlovic , C. V. ( 1998 ) . A clinical trial of the ReSound BT2 Personal Hearing System. American Journal of Audiology , 7 , 85-100 ) ."
],
"offsets": [
[
0,
343
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28249
|
split_0_train_28249
|
[
{
"id": "split_0_train_28249_passage",
"type": "progene_text",
"text": [
"Forty adult males with gradually sloping , moderate sensorineural hearing losses participated ."
],
"offsets": [
[
0,
95
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28250
|
split_0_train_28250
|
[
{
"id": "split_0_train_28250_passage",
"type": "progene_text",
"text": [
"All were experienced hearing aid users who wore linear Class D instruments with input compression limiting at the time of their enrollment in this study ."
],
"offsets": [
[
0,
154
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28251
|
split_0_train_28251
|
[
{
"id": "split_0_train_28251_passage",
"type": "progene_text",
"text": [
"The Connected Speech Test , presented at several presentation levels and under various conditions of signal degradation , and the scales and subscales of the Profile of Hearing Aid Benefit were used to evaluate hearing aid performance and benefit under four relatively independent prototype listening situations ( Walden , B. E. , Demorest , M. E. , & Hepler , E. L. ( 1984 ) . Self - report approach to assessing benefit derived from amplification. Journal of Speech and Hearing Research , 27 , 49-56 ) ."
],
"offsets": [
[
0,
505
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28252
|
split_0_train_28252
|
[
{
"id": "split_0_train_28252_passage",
"type": "progene_text",
"text": [
"Aided performance with the IC4 HD was compared with (a) unaided performance , (b) performance of persons with normal hearing , and (c) performance with linear amplification ."
],
"offsets": [
[
0,
174
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28253
|
split_0_train_28253
|
[
{
"id": "split_0_train_28253_passage",
"type": "progene_text",
"text": [
"Participants with hearing loss obtained significant benefit from the IC4 HD , although IC4 - aided performance remained well below that of unaided performance of persons with normal hearing , especially on laboratory measures of speech recognition ."
],
"offsets": [
[
0,
249
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28254
|
split_0_train_28254
|
[
{
"id": "split_0_train_28254_passage",
"type": "progene_text",
"text": [
"Furthermore , small mean performance advantages were observed for the IC4 HD compared to linear hearing aids , although there was substantial variability across participants ."
],
"offsets": [
[
0,
175
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28255
|
split_0_train_28255
|
[
{
"id": "split_0_train_28255_passage",
"type": "progene_text",
"text": [
"Finally , when given a choice to either purchase the IC4 HD at a discount from the manufacturer or continue using their own government - issued linear hearing aids , the majority of the participants chose to purchase the IC4 HD ."
],
"offsets": [
[
0,
229
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28256
|
split_0_train_28256
|
[
{
"id": "split_0_train_28256_passage",
"type": "progene_text",
"text": [
"Defective and wild - type human T-cell leukemia virus type I proviruses : characterization of gene products and trans - interactions between proviruses ."
],
"offsets": [
[
0,
153
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28257
|
split_0_train_28257
|
[
{
"id": "split_0_train_28257_passage",
"type": "progene_text",
"text": [
"Defective provirus genomes of human T-cell leukemia virus type I are frequently detected in lymphocytes from infected individuals and in infected cell lines ."
],
"offsets": [
[
0,
158
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28258
|
split_0_train_28258
|
[
{
"id": "split_0_train_28258_passage",
"type": "progene_text",
"text": [
"One type of defective provirus contains internal deletions spanning gag , pol , and env genes but retains portions of open reading frames for trans - regulatory proteins ."
],
"offsets": [
[
0,
171
]
]
}
] |
[
{
"id": "split_0_train_45782_entity",
"type": "progene_text",
"text": [
"gag"
],
"offsets": [
[
68,
71
]
],
"normalized": []
},
{
"id": "split_0_train_45783_entity",
"type": "progene_text",
"text": [
"pol"
],
"offsets": [
[
74,
77
]
],
"normalized": []
},
{
"id": "split_0_train_45784_entity",
"type": "progene_text",
"text": [
"env"
],
"offsets": [
[
84,
87
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28259
|
split_0_train_28259
|
[
{
"id": "split_0_train_28259_passage",
"type": "progene_text",
"text": [
"The deleted proviruses could potentially contribute to viral pathology by producing novel gene products that directly affect cell metabolism or that modulate expression of resident , wild - type proviruses ."
],
"offsets": [
[
0,
207
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28260
|
split_0_train_28260
|
[
{
"id": "split_0_train_28260_passage",
"type": "progene_text",
"text": [
"Virus gene products and the control of their expression were examined in cells transfected with defined molecular clones of wild - type and defective proviruses ."
],
"offsets": [
[
0,
162
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28261
|
split_0_train_28261
|
[
{
"id": "split_0_train_28261_passage",
"type": "progene_text",
"text": [
"Internally deleted provirus clones , which are unable to produce functional Tax and Rex proteins , were transcriptionally inactive in transfected cells ."
],
"offsets": [
[
0,
153
]
]
}
] |
[
{
"id": "split_0_train_45785_entity",
"type": "progene_text",
"text": [
"Tax"
],
"offsets": [
[
76,
79
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],
"normalized": []
},
{
"id": "split_0_train_45786_entity",
"type": "progene_text",
"text": [
"Rex"
],
"offsets": [
[
84,
87
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28262
|
split_0_train_28262
|
[
{
"id": "split_0_train_28262_passage",
"type": "progene_text",
"text": [
"Ectopic expression of p40Tax activated transcription of the deleted provirus , resulting in the accumulation of a two - exon mRNA that yields a truncated form of Rex ( p21Rex ) ."
],
"offsets": [
[
0,
178
]
]
}
] |
[
{
"id": "split_0_train_45787_entity",
"type": "progene_text",
"text": [
"p40Tax"
],
"offsets": [
[
22,
28
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],
"normalized": []
},
{
"id": "split_0_train_45788_entity",
"type": "progene_text",
"text": [
"Rex"
],
"offsets": [
[
162,
165
]
],
"normalized": []
},
{
"id": "split_0_train_45789_entity",
"type": "progene_text",
"text": [
"p21Rex"
],
"offsets": [
[
168,
174
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28263
|
split_0_train_28263
|
[
{
"id": "split_0_train_28263_passage",
"type": "progene_text",
"text": [
"Although this two - exon mRNA also has a potential initiation codon in the tax frame , a truncated form of Tax was not detected by immunoblotting or in transactivation assays ."
],
"offsets": [
[
0,
176
]
]
}
] |
[
{
"id": "split_0_train_45790_entity",
"type": "progene_text",
"text": [
"Tax"
],
"offsets": [
[
107,
110
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28264
|
split_0_train_28264
|
[
{
"id": "split_0_train_28264_passage",
"type": "progene_text",
"text": [
"When complemented with p40Tax and p27Rex , cells transfected with deleted proviruses accumulated an unspliced mRNA that could potentially encode gag - pX fusion proteins ."
],
"offsets": [
[
0,
171
]
]
}
] |
[
{
"id": "split_0_train_45791_entity",
"type": "progene_text",
"text": [
"p40Tax"
],
"offsets": [
[
23,
29
]
],
"normalized": []
},
{
"id": "split_0_train_45792_entity",
"type": "progene_text",
"text": [
"p27Rex"
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[
34,
40
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],
"normalized": []
},
{
"id": "split_0_train_45793_entity",
"type": "progene_text",
"text": [
"gag"
],
"offsets": [
[
145,
148
]
],
"normalized": []
},
{
"id": "split_0_train_45794_entity",
"type": "progene_text",
"text": [
"pX"
],
"offsets": [
[
151,
153
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28265
|
split_0_train_28265
|
[
{
"id": "split_0_train_28265_passage",
"type": "progene_text",
"text": [
"Although expression of deleted proviruses was dependent on trans - acting factors produced from intact proviruses , gene products from defective proviruses did not significantly affect expression of a cotransfected , full - length provirus ."
],
"offsets": [
[
0,
241
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28266
|
split_0_train_28266
|
[
{
"id": "split_0_train_28266_passage",
"type": "progene_text",
"text": [
"Zinc finger of replication protein A , a non - DNA binding element , regulates its DNA binding activity through redox ."
],
"offsets": [
[
0,
119
]
]
}
] |
[
{
"id": "split_0_train_45795_entity",
"type": "progene_text",
"text": [
"replication protein A"
],
"offsets": [
[
15,
36
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28267
|
split_0_train_28267
|
[
{
"id": "split_0_train_28267_passage",
"type": "progene_text",
"text": [
"Eukaryotic replication protein A ( RPA ) is a single - stranded DNA - binding protein with multiple functions in DNA replication , repair , and genetic recombination ."
],
"offsets": [
[
0,
167
]
]
}
] |
[
{
"id": "split_0_train_45796_entity",
"type": "progene_text",
"text": [
"replication protein A"
],
"offsets": [
[
11,
32
]
],
"normalized": []
},
{
"id": "split_0_train_45797_entity",
"type": "progene_text",
"text": [
"RPA"
],
"offsets": [
[
35,
38
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28268
|
split_0_train_28268
|
[
{
"id": "split_0_train_28268_passage",
"type": "progene_text",
"text": [
"RPA contains an evolutionarily conserved 4 - cysteine - type zinc finger motif ( X(3)CX(2-4)CX(12-15)CX(2) C ) that has a potential role in regulation of DNA replication and repair ( Dong , J. , Park , J-S. , and Lee , S-H. ( 1999 ) Biochem. J. 337 , 311 - 317 and Lin , Y. - L. , Shivji , M. K. K. , Chen , C. , Kolodner , R. , Wood , R. D. , and Dutta , A. ( 1998 ) J. Biol. Chem. 273 , 1453 - 1461 ) , even though the zinc finger itself is not essential for its DNA binding activity ( Kim , D. K. , Stigger , E. , and Lee , S. - H. ( 1996 ) J. Biol. Chem. 271 , 15124 - 15129 ) ."
],
"offsets": [
[
0,
582
]
]
}
] |
[
{
"id": "split_0_train_45798_entity",
"type": "progene_text",
"text": [
"RPA"
],
"offsets": [
[
0,
3
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28269
|
split_0_train_28269
|
[
{
"id": "split_0_train_28269_passage",
"type": "progene_text",
"text": [
"Here , we show that RPA single - stranded DNA ( ssDNA ) binding activity is regulated by reduction - oxidation ( redox ) through its zinc finger domain ."
],
"offsets": [
[
0,
153
]
]
}
] |
[
{
"id": "split_0_train_45799_entity",
"type": "progene_text",
"text": [
"RPA"
],
"offsets": [
[
20,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28270
|
split_0_train_28270
|
[
{
"id": "split_0_train_28270_passage",
"type": "progene_text",
"text": [
"RPA - ssDNA interaction was stimulated 10 - fold by the reducing agent , dithiothreitol ( DTT ) , whereas treatment of RPA with oxidizing agent , diazene dicarboxylic acid bis[N,N-dimethylamide ] ( diamide ) , significantly reduced this interaction ."
],
"offsets": [
[
0,
250
]
]
}
] |
[
{
"id": "split_0_train_45800_entity",
"type": "progene_text",
"text": [
"RPA"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_45801_entity",
"type": "progene_text",
"text": [
"RPA"
],
"offsets": [
[
119,
122
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28271
|
split_0_train_28271
|
[
{
"id": "split_0_train_28271_passage",
"type": "progene_text",
"text": [
"The effect of diamide was reversed by the addition of excess DTT , suggesting that RPA ssDNA binding activity is regulated by redox ."
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "split_0_train_45802_entity",
"type": "progene_text",
"text": [
"RPA"
],
"offsets": [
[
83,
86
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28272
|
split_0_train_28272
|
[
{
"id": "split_0_train_28272_passage",
"type": "progene_text",
"text": [
"Redox regulation of RPA - ssDNA interaction was more effective in the presence of 0.2 M NaCl or higher ."
],
"offsets": [
[
0,
104
]
]
}
] |
[
{
"id": "split_0_train_45803_entity",
"type": "progene_text",
"text": [
"RPA"
],
"offsets": [
[
20,
23
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28273
|
split_0_train_28273
|
[
{
"id": "split_0_train_28273_passage",
"type": "progene_text",
"text": [
"Cellular redox factor , thioredoxin , was able to replace DTT in stimulation of RPA DNA binding activity , suggesting that redox protein may be involved in RPA modulation in vivo ."
],
"offsets": [
[
0,
180
]
]
}
] |
[
{
"id": "split_0_train_45804_entity",
"type": "progene_text",
"text": [
"RPA"
],
"offsets": [
[
80,
83
]
],
"normalized": []
},
{
"id": "split_0_train_45805_entity",
"type": "progene_text",
"text": [
"RPA"
],
"offsets": [
[
156,
159
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28274
|
split_0_train_28274
|
[
{
"id": "split_0_train_28274_passage",
"type": "progene_text",
"text": [
"In contrast to wild - type RPA , zinc finger mutant ( cysteine to alanine mutation at amino acid 486 ) did not require DTT for its ssDNA binding activity and is not affected by redox ."
],
"offsets": [
[
0,
184
]
]
}
] |
[
{
"id": "split_0_train_45806_entity",
"type": "progene_text",
"text": [
"RPA"
],
"offsets": [
[
27,
30
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28275
|
split_0_train_28275
|
[
{
"id": "split_0_train_28275_passage",
"type": "progene_text",
"text": [
"Together , these results suggest a novel function for a putative zinc finger in the regulation of RPA DNA binding activity through cellular redox ."
],
"offsets": [
[
0,
147
]
]
}
] |
[
{
"id": "split_0_train_45807_entity",
"type": "progene_text",
"text": [
"RPA"
],
"offsets": [
[
98,
101
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28276
|
split_0_train_28276
|
[
{
"id": "split_0_train_28276_passage",
"type": "progene_text",
"text": [
"Complex formation with focal adhesion kinase :"
],
"offsets": [
[
0,
46
]
]
}
] |
[
{
"id": "split_0_train_45808_entity",
"type": "progene_text",
"text": [
"focal adhesion kinase"
],
"offsets": [
[
23,
44
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28277
|
split_0_train_28277
|
[
{
"id": "split_0_train_28277_passage",
"type": "progene_text",
"text": [
"A mechanism to regulate activity and subcellular localization of Src kinases ."
],
"offsets": [
[
0,
78
]
]
}
] |
[
{
"id": "split_0_train_45809_entity",
"type": "progene_text",
"text": [
"Src"
],
"offsets": [
[
65,
68
]
],
"normalized": []
},
{
"id": "split_0_train_45810_entity",
"type": "progene_text",
"text": [
"kinases"
],
"offsets": [
[
69,
76
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28278
|
split_0_train_28278
|
[
{
"id": "split_0_train_28278_passage",
"type": "progene_text",
"text": [
"Tyrosine phosphorylation of focal adhesion kinase ( FAK ) creates a high - affinity binding site for the src homology 2 domain of the Src family of tyrosine kinases ."
],
"offsets": [
[
0,
166
]
]
}
] |
[
{
"id": "split_0_train_45811_entity",
"type": "progene_text",
"text": [
"focal adhesion kinase"
],
"offsets": [
[
28,
49
]
],
"normalized": []
},
{
"id": "split_0_train_45812_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
52,
55
]
],
"normalized": []
},
{
"id": "split_0_train_45813_entity",
"type": "progene_text",
"text": [
"src"
],
"offsets": [
[
105,
108
]
],
"normalized": []
},
{
"id": "split_0_train_45814_entity",
"type": "progene_text",
"text": [
"Src family of tyrosine kinases"
],
"offsets": [
[
134,
164
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28279
|
split_0_train_28279
|
[
{
"id": "split_0_train_28279_passage",
"type": "progene_text",
"text": [
"Assembly of a complex between FAK and Src kinases may serve to regulate the subcellular localization and the enzymatic activity of members of the Src family of kinases ."
],
"offsets": [
[
0,
169
]
]
}
] |
[
{
"id": "split_0_train_45815_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
30,
33
]
],
"normalized": []
},
{
"id": "split_0_train_45816_entity",
"type": "progene_text",
"text": [
"Src"
],
"offsets": [
[
38,
41
]
],
"normalized": []
},
{
"id": "split_0_train_45817_entity",
"type": "progene_text",
"text": [
"kinases"
],
"offsets": [
[
42,
49
]
],
"normalized": []
},
{
"id": "split_0_train_45818_entity",
"type": "progene_text",
"text": [
"Src family of kinases"
],
"offsets": [
[
146,
167
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28280
|
split_0_train_28280
|
[
{
"id": "split_0_train_28280_passage",
"type": "progene_text",
"text": [
"We show that simultaneous overexpression of FAK and pp60(c-src ) or p59 ( fyn ) results in the enhancement of the tyrosine phosphorylation of a limited number of cellular substrates , including paxillin ."
],
"offsets": [
[
0,
204
]
]
}
] |
[
{
"id": "split_0_train_45819_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
44,
47
]
],
"normalized": []
},
{
"id": "split_0_train_45820_entity",
"type": "progene_text",
"text": [
"pp60(c-src )"
],
"offsets": [
[
52,
64
]
],
"normalized": []
},
{
"id": "split_0_train_45821_entity",
"type": "progene_text",
"text": [
"p59 ( fyn )"
],
"offsets": [
[
68,
79
]
],
"normalized": []
},
{
"id": "split_0_train_45822_entity",
"type": "progene_text",
"text": [
"paxillin"
],
"offsets": [
[
194,
202
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28281
|
split_0_train_28281
|
[
{
"id": "split_0_train_28281_passage",
"type": "progene_text",
"text": [
"Under these conditions , tyrosine phosphorylation of paxillin is largely cell adhesion dependent ."
],
"offsets": [
[
0,
98
]
]
}
] |
[
{
"id": "split_0_train_45823_entity",
"type": "progene_text",
"text": [
"paxillin"
],
"offsets": [
[
53,
61
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28282
|
split_0_train_28282
|
[
{
"id": "split_0_train_28282_passage",
"type": "progene_text",
"text": [
"FAK mutants defective for Src binding or focal adhesion targeting fail to cooperate with pp60(c-src ) or p59 ( fyn ) to induce paxillin phosphorylation , whereas catalytically defective FAK mutants can direct paxillin phosphorylation ."
],
"offsets": [
[
0,
235
]
]
}
] |
[
{
"id": "split_0_train_45824_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "split_0_train_45825_entity",
"type": "progene_text",
"text": [
"Src"
],
"offsets": [
[
26,
29
]
],
"normalized": []
},
{
"id": "split_0_train_45826_entity",
"type": "progene_text",
"text": [
"pp60(c-src )"
],
"offsets": [
[
89,
101
]
],
"normalized": []
},
{
"id": "split_0_train_45827_entity",
"type": "progene_text",
"text": [
"p59 ( fyn )"
],
"offsets": [
[
105,
116
]
],
"normalized": []
},
{
"id": "split_0_train_45828_entity",
"type": "progene_text",
"text": [
"paxillin"
],
"offsets": [
[
127,
135
]
],
"normalized": []
},
{
"id": "split_0_train_45829_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
186,
189
]
],
"normalized": []
},
{
"id": "split_0_train_45830_entity",
"type": "progene_text",
"text": [
"paxillin"
],
"offsets": [
[
209,
217
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28283
|
split_0_train_28283
|
[
{
"id": "split_0_train_28283_passage",
"type": "progene_text",
"text": [
"The negative regulatory site of pp60(c-src ) is hypophosphorylated when in complex with FAK , and coexpression with FAK leads to a redistribution of pp60(c-src ) from a diffuse cellular location to focal adhesions ."
],
"offsets": [
[
0,
215
]
]
}
] |
[
{
"id": "split_0_train_45831_entity",
"type": "progene_text",
"text": [
"pp60(c-src"
],
"offsets": [
[
32,
42
]
],
"normalized": []
},
{
"id": "split_0_train_45832_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
88,
91
]
],
"normalized": []
},
{
"id": "split_0_train_45833_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
116,
119
]
],
"normalized": []
},
{
"id": "split_0_train_45834_entity",
"type": "progene_text",
"text": [
"pp60(c-src )"
],
"offsets": [
[
149,
161
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28284
|
split_0_train_28284
|
[
{
"id": "split_0_train_28284_passage",
"type": "progene_text",
"text": [
"A FAK mutant defective for Src binding does not effectively induce the translocation of pp60(c-src ) to focal adhesions ."
],
"offsets": [
[
0,
121
]
]
}
] |
[
{
"id": "split_0_train_45835_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
2,
5
]
],
"normalized": []
},
{
"id": "split_0_train_45836_entity",
"type": "progene_text",
"text": [
"Src"
],
"offsets": [
[
27,
30
]
],
"normalized": []
},
{
"id": "split_0_train_45837_entity",
"type": "progene_text",
"text": [
"pp60(c-src )"
],
"offsets": [
[
88,
100
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28285
|
split_0_train_28285
|
[
{
"id": "split_0_train_28285_passage",
"type": "progene_text",
"text": [
"These results suggest that association with FAK can alter the localization of Src kinases and that FAK functions to direct phosphorylation of cellular substrates by recruitment of Src kinases ."
],
"offsets": [
[
0,
193
]
]
}
] |
[
{
"id": "split_0_train_45838_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
44,
47
]
],
"normalized": []
},
{
"id": "split_0_train_45839_entity",
"type": "progene_text",
"text": [
"Src"
],
"offsets": [
[
78,
81
]
],
"normalized": []
},
{
"id": "split_0_train_45840_entity",
"type": "progene_text",
"text": [
"kinases"
],
"offsets": [
[
82,
89
]
],
"normalized": []
},
{
"id": "split_0_train_45841_entity",
"type": "progene_text",
"text": [
"FAK"
],
"offsets": [
[
99,
102
]
],
"normalized": []
},
{
"id": "split_0_train_45842_entity",
"type": "progene_text",
"text": [
"Src"
],
"offsets": [
[
180,
183
]
],
"normalized": []
},
{
"id": "split_0_train_45843_entity",
"type": "progene_text",
"text": [
"kinases"
],
"offsets": [
[
184,
191
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28286
|
split_0_train_28286
|
[
{
"id": "split_0_train_28286_passage",
"type": "progene_text",
"text": [
"The long - term antihypertensive activity and tolerability of irbesartan with hydrochlorothiazide ."
],
"offsets": [
[
0,
99
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28287
|
split_0_train_28287
|
[
{
"id": "split_0_train_28287_passage",
"type": "progene_text",
"text": [
"The long - term safety , tolerability , and antihypertensive effects of irbesartan / hydrochlorothiazide ( HCTZ ) were assessed in hypertensive patients ( seated diastolic blood pressure [ SeDBP ] 95-110 mm Hg ) ."
],
"offsets": [
[
0,
213
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28288
|
split_0_train_28288
|
[
{
"id": "split_0_train_28288_passage",
"type": "progene_text",
"text": [
"Patients ( n = 1098 ) completing two randomised , double - blind trials of irbesartan alone , HCTZ alone , irbesartan / HCTZ combinations , or placebo , took 1 year of open - label therapy starting with irbesartan 75 mg / HCTZ 12.5 mg once daily ."
],
"offsets": [
[
0,
247
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28289
|
split_0_train_28289
|
[
{
"id": "split_0_train_28289_passage",
"type": "progene_text",
"text": [
"If target blood pressure ( BP ) ( < 140 / < 90 mm Hg ) was not achieved , the dose was titrated sequentially at 2 - to 4 - week intervals to irbesartan 150 mg / HCTZ 12 ."
],
"offsets": [
[
0,
170
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28290
|
split_0_train_28290
|
[
{
"id": "split_0_train_28290_passage",
"type": "progene_text",
"text": [
"5 mg , then to irbesartan 300 mg / HCTZ 25 mg ."
],
"offsets": [
[
0,
47
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28291
|
split_0_train_28291
|
[
{
"id": "split_0_train_28291_passage",
"type": "progene_text",
"text": [
"If necessary , adjunctive therapies were added ."
],
"offsets": [
[
0,
48
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28292
|
split_0_train_28292
|
[
{
"id": "split_0_train_28292_passage",
"type": "progene_text",
"text": [
"Mean changes in trough seated systolic BP / SeDBP at months 2 , 6 , and 12 were - 19.1 / - 14.2 mm Hg ( n = 941 ) , - 20.7 / - 15.7 mm Hg ( n = 948 ) , and - 20.6 / - 15.6 mm Hg ( n = 898 ) , respectively ."
],
"offsets": [
[
0,
206
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28293
|
split_0_train_28293
|
[
{
"id": "split_0_train_28293_passage",
"type": "progene_text",
"text": [
"From months 2 to 12 , normalisation rates ( trough SeDBP < 90 mm Hg ) ranged from 75 - 85 % and total responder rates ( normalised or > / = 10 mm Hg trough SeDBP reduction ) ranged from 81 - 91 % , while target BP was achieved in 65 - 75 % of patients ."
],
"offsets": [
[
0,
253
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28294
|
split_0_train_28294
|
[
{
"id": "split_0_train_28294_passage",
"type": "progene_text",
"text": [
"At all time - points , most patients ( > / = 87 % ) were receiving irbesartan / HCTZ alone ."
],
"offsets": [
[
0,
92
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28295
|
split_0_train_28295
|
[
{
"id": "split_0_train_28295_passage",
"type": "progene_text",
"text": [
"Eighty - two patients ( 7.5 % ) discontinued the study due to adverse events , with half of these events considered unrelated to study medication ."
],
"offsets": [
[
0,
147
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28296
|
split_0_train_28296
|
[
{
"id": "split_0_train_28296_passage",
"type": "progene_text",
"text": [
"There were no reports of serious adverse events related to study medication ."
],
"offsets": [
[
0,
77
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28297
|
split_0_train_28297
|
[
{
"id": "split_0_train_28297_passage",
"type": "progene_text",
"text": [
"Long - term therapy with irbesartan / HCTZ is safe , well tolerated , and maintains normalised BP in > 80 % of patients ."
],
"offsets": [
[
0,
121
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28298
|
split_0_train_28298
|
[
{
"id": "split_0_train_28298_passage",
"type": "progene_text",
"text": [
"[ Thyroid function in elderly with neoplasms ]"
],
"offsets": [
[
0,
46
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28299
|
split_0_train_28299
|
[
{
"id": "split_0_train_28299_passage",
"type": "progene_text",
"text": [
"BACKGROUND :"
],
"offsets": [
[
0,
12
]
]
}
] |
[] |
[] |
[] |
[] |
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