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stringlengths 15
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split_0_train_28400
|
split_0_train_28400
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"Preincubation with wortmannin and LY294002 , two structurally and mechanistically different inhibitors of PI3-K , blocked the VS - mediated increase in MAPK activity and phosphorylation of ERK-1 and ERK-2 ."
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199,
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[] |
[] |
[] |
split_0_train_28401
|
split_0_train_28401
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"Furthermore , wortmannin inhibited activation of ras , C-raf-1 , and MEK in response to VS ."
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"MEK"
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69,
72
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] |
[] |
[] |
[] |
split_0_train_28402
|
split_0_train_28402
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[
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"The addition of a farnesyltransferase inhibitor , B581 , to cells reduced the level of MAPK activation as well as ERK-1 and ERK-2 phosphorylation stimulated by VS ."
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164
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"ERK-2"
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124,
129
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] |
[] |
[] |
[] |
split_0_train_28403
|
split_0_train_28403
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[
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"text": [
"Finally , VS increased PI3-K activity in ras immunoprecipitates ."
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23,
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"text": [
"ras"
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41,
44
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}
] |
[] |
[] |
[] |
split_0_train_28404
|
split_0_train_28404
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[
{
"id": "split_0_train_28404_passage",
"type": "progene_text",
"text": [
"A VS - mediated increase in p70(s6k) activity was also found to be inhibited by wortmannin ."
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0,
92
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"p70(s6k)"
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28,
36
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] |
[] |
[] |
[] |
split_0_train_28405
|
split_0_train_28405
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[
{
"id": "split_0_train_28405_passage",
"type": "progene_text",
"text": [
"Taken together , these results demonstrate that the insulinomimetic effects of VS may be mediated , in part , by PI3 - K - dependent stimulation of the ras - MAPK and p70(s6k) pathways ."
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186
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155
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158,
162
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"text": [
"p70(s6k)"
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"offsets": [
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167,
175
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],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28406
|
split_0_train_28406
|
[
{
"id": "split_0_train_28406_passage",
"type": "progene_text",
"text": [
"A phase II trial of DA-125 , a novel anthracycline , in advanced non - small - cell lung cancer ."
],
"offsets": [
[
0,
97
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28407
|
split_0_train_28407
|
[
{
"id": "split_0_train_28407_passage",
"type": "progene_text",
"text": [
"PURPOSE :"
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[
0,
9
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28408
|
split_0_train_28408
|
[
{
"id": "split_0_train_28408_passage",
"type": "progene_text",
"text": [
"DA-125 is a novel anthracycline derivative developed by Dong-A Pharmaceutical Company , Korea ."
],
"offsets": [
[
0,
95
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28409
|
split_0_train_28409
|
[
{
"id": "split_0_train_28409_passage",
"type": "progene_text",
"text": [
"Preclinical studies have suggested that DA-125 has greater efficacy and less toxicity than doxorubicin ."
],
"offsets": [
[
0,
104
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28410
|
split_0_train_28410
|
[
{
"id": "split_0_train_28410_passage",
"type": "progene_text",
"text": [
"The maximum tolerable dose has been shown to be 100 mg / m(2 ) in a phase I trial ."
],
"offsets": [
[
0,
83
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28411
|
split_0_train_28411
|
[
{
"id": "split_0_train_28411_passage",
"type": "progene_text",
"text": [
"The purpose of this phase II study was to evaluate the efficacy and toxicity of DA-125 in patients with non - small - cell lung cancer ( NSCLC ) ."
],
"offsets": [
[
0,
146
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28412
|
split_0_train_28412
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[
{
"id": "split_0_train_28412_passage",
"type": "progene_text",
"text": [
"METHODS :"
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[
0,
9
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28413
|
split_0_train_28413
|
[
{
"id": "split_0_train_28413_passage",
"type": "progene_text",
"text": [
"Chemotherapy - naive patients with histologically confirmed measurable NSCLC which was not curable by surgery or radiation therapy because of metastasis , local invasion , or recurrence were eligible for this trial ."
],
"offsets": [
[
0,
216
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28414
|
split_0_train_28414
|
[
{
"id": "split_0_train_28414_passage",
"type": "progene_text",
"text": [
"Between May 1996 and April 1997 , 20 patients entered into this trial and were treated with DA-125 administered as a 5 - min intravenous infusion every 3 weeks ."
],
"offsets": [
[
0,
161
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28415
|
split_0_train_28415
|
[
{
"id": "split_0_train_28415_passage",
"type": "progene_text",
"text": [
"The dose of DA-125 was 80 mg / m ( 2 ) during the first cycle , and was adjusted to between 60 and 100 mg / m(2) according to the observed toxicities during subsequent cycles ."
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[
0,
176
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}
] |
[] |
[] |
[] |
[] |
split_0_train_28416
|
split_0_train_28416
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[
{
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"type": "progene_text",
"text": [
"RESULTS :"
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0,
9
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}
] |
[] |
[] |
[] |
[] |
split_0_train_28417
|
split_0_train_28417
|
[
{
"id": "split_0_train_28417_passage",
"type": "progene_text",
"text": [
"Among 19 evaluable patients , there was no objective response to DA-125 ."
],
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0,
73
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28418
|
split_0_train_28418
|
[
{
"id": "split_0_train_28418_passage",
"type": "progene_text",
"text": [
"Anemia , leukopenia and granulocytopenia of grade 3 or over were observed in 4 % , 6 % and 12 % of chemotherapy cycles , respectively ."
],
"offsets": [
[
0,
135
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28419
|
split_0_train_28419
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{
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"type": "progene_text",
"text": [
"There were no treatment - related deaths ."
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0,
42
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}
] |
[] |
[] |
[] |
[] |
split_0_train_28420
|
split_0_train_28420
|
[
{
"id": "split_0_train_28420_passage",
"type": "progene_text",
"text": [
"With regard to nonhematologic toxicities , diarrhea , infection and elevated serum alkaline phosphatase of grade 3 or over were observed in 2 % of cycles , but were tolerable and reversible ."
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[
0,
191
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}
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{
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"alkaline phosphatase"
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83,
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] |
[] |
[] |
[] |
split_0_train_28421
|
split_0_train_28421
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[
{
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"type": "progene_text",
"text": [
"CONCLUSION :"
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0,
12
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}
] |
[] |
[] |
[] |
[] |
split_0_train_28422
|
split_0_train_28422
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[
{
"id": "split_0_train_28422_passage",
"type": "progene_text",
"text": [
"DA-125 at these doses and in this schedule was highly tolerable , but was not active in patients with advanced NSCLC ."
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0,
118
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}
] |
[] |
[] |
[] |
[] |
split_0_train_28423
|
split_0_train_28423
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[
{
"id": "split_0_train_28423_passage",
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"text": [
"Factor XI deficiency : literature review and case presentation ."
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0,
64
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{
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"text": [
"Factor XI"
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0,
9
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}
] |
[] |
[] |
[] |
split_0_train_28424
|
split_0_train_28424
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[
{
"id": "split_0_train_28424_passage",
"type": "progene_text",
"text": [
"Factor XI deficiency is a rare hereditary bleeding disorder affecting the intrinsic pathway ."
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"offsets": [
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0,
93
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}
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"text": [
"Factor XI"
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0,
9
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}
] |
[] |
[] |
[] |
split_0_train_28425
|
split_0_train_28425
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[
{
"id": "split_0_train_28425_passage",
"type": "progene_text",
"text": [
"Understanding the pathophysiology and clinical significance of this disease entity can help avoid potentially hazardous sequelae ."
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0,
130
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28426
|
split_0_train_28426
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[
{
"id": "split_0_train_28426_passage",
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"text": [
"This case presentation discusses laboratory criteria and serum assaying techniques utilized to appropriately manage preoperative or post - traumatic patients suffering from factor XI deficiency ."
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0,
195
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"factor XI"
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173,
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] |
[] |
[] |
[] |
split_0_train_28427
|
split_0_train_28427
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[
{
"id": "split_0_train_28427_passage",
"type": "progene_text",
"text": [
"Cardiac looping and the vertebrate left - right axis : antagonism of left - sided Vg1 activity by a right - sided ALK2 - dependent BMP pathway ."
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"offsets": [
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0,
144
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{
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114,
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"BMP"
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131,
134
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}
] |
[] |
[] |
[] |
split_0_train_28428
|
split_0_train_28428
|
[
{
"id": "split_0_train_28428_passage",
"type": "progene_text",
"text": [
"The rightward looping of the primary heart tube is dependent upon upstream patterning events that establish the vertebrate left - right axis ."
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0,
142
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]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28429
|
split_0_train_28429
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[
{
"id": "split_0_train_28429_passage",
"type": "progene_text",
"text": [
"In Xenopus , a left - sided Vg1 signaling pathway has been implicated in instructing cells to adopt a ' left - sided identity ' ; however , it is not known whether ' right - sided identity ' is acquired by a default pathway or by antagonism of Vg1 signaling ."
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259
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244,
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[] |
[] |
[] |
split_0_train_28430
|
split_0_train_28430
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"Here , we propose that an antagonistic , BMP / ALK2 / Smad - mediated signaling pathway is active on the right side of the Xenopus embryo ."
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0,
139
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54,
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[] |
[] |
[] |
split_0_train_28431
|
split_0_train_28431
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123
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10,
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[] |
[] |
[] |
split_0_train_28432
|
split_0_train_28432
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{
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"Consistent with these findings , constitutively active ALK2 ( CA - ALK2 ) receptor expression on the left side of the blastula also elicits heart reversals and altered nodal expression ."
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186
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"ALK2"
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67,
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[] |
[] |
[] |
split_0_train_28433
|
split_0_train_28433
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{
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"text": [
"Coexpression of CA - ALK2 with mature Vg1 ligand results in predominantly left - sided nodal expression patterns and normal heart looping , demonstrating that the ALK2 pathway can 'rescue' left-right reversals that otherwise occur following right - sided misexpression of mature Vg1 ligand alone ."
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297
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163,
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"Vg1"
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279,
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] |
[] |
[] |
[] |
split_0_train_28434
|
split_0_train_28434
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{
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171
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{
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"type": "progene_text",
"text": [
"BMP"
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76,
79
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],
"normalized": []
},
{
"id": "split_0_train_46017_entity",
"type": "progene_text",
"text": [
"ALK2"
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"offsets": [
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117,
121
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],
"normalized": []
},
{
"id": "split_0_train_46018_entity",
"type": "progene_text",
"text": [
"Vg1"
],
"offsets": [
[
158,
161
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28435
|
split_0_train_28435
|
[
{
"id": "split_0_train_28435_passage",
"type": "progene_text",
"text": [
"Consistent with the observed antagonism between BMP and Vg1 ligands , left - sided ectopic expression of Xolloid results in heart reversals ."
],
"offsets": [
[
0,
141
]
]
}
] |
[
{
"id": "split_0_train_46019_entity",
"type": "progene_text",
"text": [
"BMP"
],
"offsets": [
[
48,
51
]
],
"normalized": []
},
{
"id": "split_0_train_46020_entity",
"type": "progene_text",
"text": [
"Vg1"
],
"offsets": [
[
56,
59
]
],
"normalized": []
},
{
"id": "split_0_train_46021_entity",
"type": "progene_text",
"text": [
"Xolloid"
],
"offsets": [
[
105,
112
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28436
|
split_0_train_28436
|
[
{
"id": "split_0_train_28436_passage",
"type": "progene_text",
"text": [
"Moreover , ectopic expression of Smad1 or Smad7 identified two downstream modulators of the BMP / ALK2 signaling pathway that also can regulate cardiac orientation ."
],
"offsets": [
[
0,
165
]
]
}
] |
[
{
"id": "split_0_train_46022_entity",
"type": "progene_text",
"text": [
"Smad1"
],
"offsets": [
[
33,
38
]
],
"normalized": []
},
{
"id": "split_0_train_46023_entity",
"type": "progene_text",
"text": [
"Smad7"
],
"offsets": [
[
42,
47
]
],
"normalized": []
},
{
"id": "split_0_train_46024_entity",
"type": "progene_text",
"text": [
"BMP"
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"offsets": [
[
92,
95
]
],
"normalized": []
},
{
"id": "split_0_train_46025_entity",
"type": "progene_text",
"text": [
"ALK2"
],
"offsets": [
[
98,
102
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28437
|
split_0_train_28437
|
[
{
"id": "split_0_train_28437_passage",
"type": "progene_text",
"text": [
"Collectively , these results define a BMP / ALK2 - mediated pathway on the right side of the Xenopus embryo and , moreover , suggest that left - right patterning preceding cardiac morphogenesis involves the activation of two distinct and antagonistic , left - and right - sided TGF ( beta ) - related signaling pathways ."
],
"offsets": [
[
0,
321
]
]
}
] |
[
{
"id": "split_0_train_46026_entity",
"type": "progene_text",
"text": [
"BMP"
],
"offsets": [
[
38,
41
]
],
"normalized": []
},
{
"id": "split_0_train_46027_entity",
"type": "progene_text",
"text": [
"ALK2"
],
"offsets": [
[
44,
48
]
],
"normalized": []
},
{
"id": "split_0_train_46028_entity",
"type": "progene_text",
"text": [
"TGF ( beta )"
],
"offsets": [
[
278,
290
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28438
|
split_0_train_28438
|
[
{
"id": "split_0_train_28438_passage",
"type": "progene_text",
"text": [
"Genomic organization of the mouse and human genes encoding the ATP sulfurylase / adenosine 5'-phosphosulfate kinase isoform SK2 ."
],
"offsets": [
[
0,
129
]
]
}
] |
[
{
"id": "split_0_train_46029_entity",
"type": "progene_text",
"text": [
"ATP sulfurylase / adenosine 5'-phosphosulfate kinase isoform SK2"
],
"offsets": [
[
63,
127
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28439
|
split_0_train_28439
|
[
{
"id": "split_0_train_28439_passage",
"type": "progene_text",
"text": [
"Mammalian ATP sulfurylase / adenosine 5'-phosphosulfate ( APS ) kinase consists of kinase and sulfurylase domains , and catalyzes two sequential reactions to synthesize the universal sulfate donor , phosphoadenosine phosphosulfate ( PAPS ) ."
],
"offsets": [
[
0,
241
]
]
}
] |
[
{
"id": "split_0_train_46030_entity",
"type": "progene_text",
"text": [
"ATP sulfurylase / adenosine 5'-phosphosulfate ( APS ) kinase"
],
"offsets": [
[
10,
70
]
],
"normalized": []
},
{
"id": "split_0_train_46031_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
83,
89
]
],
"normalized": []
},
{
"id": "split_0_train_46032_entity",
"type": "progene_text",
"text": [
"sulfurylase"
],
"offsets": [
[
94,
105
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28440
|
split_0_train_28440
|
[
{
"id": "split_0_train_28440_passage",
"type": "progene_text",
"text": [
"In simpler organisms , the ATP sulfurylase and APS kinase reactions are catalyzed by separate enzymes encoded by two or three genes , suggesting that a fusion of separate genes during the course of evolution generated the bifunctional enzyme ."
],
"offsets": [
[
0,
243
]
]
}
] |
[
{
"id": "split_0_train_46033_entity",
"type": "progene_text",
"text": [
"ATP sulfurylase"
],
"offsets": [
[
27,
42
]
],
"normalized": []
},
{
"id": "split_0_train_46034_entity",
"type": "progene_text",
"text": [
"APS kinase"
],
"offsets": [
[
47,
57
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28441
|
split_0_train_28441
|
[
{
"id": "split_0_train_28441_passage",
"type": "progene_text",
"text": [
"We have characterized the genomic structure of the PAPS synthetase SK2 isoform genes for mouse ( MSK2 ) and human ( HSK2 ) and analyzed the possible fusion region ."
],
"offsets": [
[
0,
164
]
]
}
] |
[
{
"id": "split_0_train_46035_entity",
"type": "progene_text",
"text": [
"PAPS synthetase SK2"
],
"offsets": [
[
51,
70
]
],
"normalized": []
},
{
"id": "split_0_train_46036_entity",
"type": "progene_text",
"text": [
"MSK2"
],
"offsets": [
[
97,
101
]
],
"normalized": []
},
{
"id": "split_0_train_46037_entity",
"type": "progene_text",
"text": [
"HSK2"
],
"offsets": [
[
116,
120
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28442
|
split_0_train_28442
|
[
{
"id": "split_0_train_28442_passage",
"type": "progene_text",
"text": [
"The MSK2 and HSK2 genes exhibit a common structure of 13 exons , including a 15 - nucleotide alternatively spliced exon 8 ."
],
"offsets": [
[
0,
123
]
]
}
] |
[
{
"id": "split_0_train_46038_entity",
"type": "progene_text",
"text": [
"MSK2"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_46039_entity",
"type": "progene_text",
"text": [
"HSK2"
],
"offsets": [
[
13,
17
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28443
|
split_0_train_28443
|
[
{
"id": "split_0_train_28443_passage",
"type": "progene_text",
"text": [
"Enzyme activities of several bacterially expressed exon assemblages showed exons 1 - 6 encode APS kinase , while exons 6 - 13 encode ATP sulfurylase ."
],
"offsets": [
[
0,
150
]
]
}
] |
[
{
"id": "split_0_train_46040_entity",
"type": "progene_text",
"text": [
"APS kinase"
],
"offsets": [
[
94,
104
]
],
"normalized": []
},
{
"id": "split_0_train_46041_entity",
"type": "progene_text",
"text": [
"ATP sulfurylase"
],
"offsets": [
[
133,
148
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28444
|
split_0_train_28444
|
[
{
"id": "split_0_train_28444_passage",
"type": "progene_text",
"text": [
"The MSK2 construct without the exon 6 - encoded peptide showed no kinase or sulfurylase activity , demonstrating that exon 6 encodes sequences required for both activities ."
],
"offsets": [
[
0,
173
]
]
}
] |
[
{
"id": "split_0_train_46042_entity",
"type": "progene_text",
"text": [
"MSK2"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_46043_entity",
"type": "progene_text",
"text": [
"kinase"
],
"offsets": [
[
66,
72
]
],
"normalized": []
},
{
"id": "split_0_train_46044_entity",
"type": "progene_text",
"text": [
"sulfurylase"
],
"offsets": [
[
76,
87
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28445
|
split_0_train_28445
|
[
{
"id": "split_0_train_28445_passage",
"type": "progene_text",
"text": [
"Exon 1 and its 5' - flanking sequence are highly divergent between the two species , and intron 1 of the HSK2 gene contains a region similar to the MSK2 promoter sequence , suggesting that it may be the remnant of a now - superceded regulatory region ."
],
"offsets": [
[
0,
252
]
]
}
] |
[
{
"id": "split_0_train_46045_entity",
"type": "progene_text",
"text": [
"HSK2"
],
"offsets": [
[
105,
109
]
],
"normalized": []
},
{
"id": "split_0_train_46046_entity",
"type": "progene_text",
"text": [
"MSK2"
],
"offsets": [
[
148,
152
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28446
|
split_0_train_28446
|
[
{
"id": "split_0_train_28446_passage",
"type": "progene_text",
"text": [
"The HSK2 promoter contains a GC - rich region , not present in the mouse promoter , and has few transcription factor binding sites in common with MSK2 ."
],
"offsets": [
[
0,
152
]
]
}
] |
[
{
"id": "split_0_train_46047_entity",
"type": "progene_text",
"text": [
"HSK2"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "split_0_train_46048_entity",
"type": "progene_text",
"text": [
"transcription factor"
],
"offsets": [
[
96,
116
]
],
"normalized": []
},
{
"id": "split_0_train_46049_entity",
"type": "progene_text",
"text": [
"MSK2"
],
"offsets": [
[
146,
150
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28447
|
split_0_train_28447
|
[
{
"id": "split_0_train_28447_passage",
"type": "progene_text",
"text": [
"These differences in the two promoter regions suggest that species - specific mechanisms regulate expression of the SK2 isoform ."
],
"offsets": [
[
0,
129
]
]
}
] |
[
{
"id": "split_0_train_46050_entity",
"type": "progene_text",
"text": [
"SK2"
],
"offsets": [
[
116,
119
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28448
|
split_0_train_28448
|
[
{
"id": "split_0_train_28448_passage",
"type": "progene_text",
"text": [
"Glycosylation and proteolytic processing of 70 kDa C - terminal recombinant polypeptides of Plasmodium falciparum merozoite surface protein 1 expressed in mammalian cells ."
],
"offsets": [
[
0,
172
]
]
}
] |
[
{
"id": "split_0_train_46051_entity",
"type": "progene_text",
"text": [
"merozoite surface protein 1"
],
"offsets": [
[
114,
141
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28449
|
split_0_train_28449
|
[
{
"id": "split_0_train_28449_passage",
"type": "progene_text",
"text": [
"The cDNAs that encode the 70 kDa C - terminal portion of Plasmodium falciparum merozoite surface protein 1 ( MSP-1 ) , with or without an N - terminal signal peptide sequence and C - terminal glycosylphosphatidylinositol ( GPI ) signal sequence of MSP-1 , were expressed in mammalian cell lines via recombinant vaccinia virus ."
],
"offsets": [
[
0,
327
]
]
}
] |
[
{
"id": "split_0_train_46052_entity",
"type": "progene_text",
"text": [
"merozoite surface protein 1"
],
"offsets": [
[
79,
106
]
],
"normalized": []
},
{
"id": "split_0_train_46053_entity",
"type": "progene_text",
"text": [
"MSP-1"
],
"offsets": [
[
109,
114
]
],
"normalized": []
},
{
"id": "split_0_train_46054_entity",
"type": "progene_text",
"text": [
"MSP-1"
],
"offsets": [
[
248,
253
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28450
|
split_0_train_28450
|
[
{
"id": "split_0_train_28450_passage",
"type": "progene_text",
"text": [
"The polypeptides were studied with respect to the nature of glycosylation , localization , and proteolytic processing ."
],
"offsets": [
[
0,
119
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28451
|
split_0_train_28451
|
[
{
"id": "split_0_train_28451_passage",
"type": "progene_text",
"text": [
"The polypeptides derived from the cDNAs that contained the N - terminal signal peptide were modified with N - linked high mannose type structures and low levels of O - linked oligosaccharides , whereas the polypeptides from the cDNAs that lacked the signal peptide were not glycosylated ."
],
"offsets": [
[
0,
288
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28452
|
split_0_train_28452
|
[
{
"id": "split_0_train_28452_passage",
"type": "progene_text",
"text": [
"The GPI anchor moiety is either absent or present at a very low level in the polypeptide expressed from the cDNA that contained both the signal peptide and GPI signal sequences ."
],
"offsets": [
[
0,
178
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28453
|
split_0_train_28453
|
[
{
"id": "split_0_train_28453_passage",
"type": "progene_text",
"text": [
"Together , these data establish that whereas the signal peptide of MSP-1 is functional , the GPI anchor signal is either nonfunctional or poorly functional in mammalian cells ."
],
"offsets": [
[
0,
176
]
]
}
] |
[
{
"id": "split_0_train_46055_entity",
"type": "progene_text",
"text": [
"MSP-1"
],
"offsets": [
[
67,
72
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28454
|
split_0_train_28454
|
[
{
"id": "split_0_train_28454_passage",
"type": "progene_text",
"text": [
"The polypeptides expressed from the cDNAs that contained the signal peptide were proteolytically cleaved at their C - termini , whereas the polypeptides expressed from the cDNAs that lacked the signal peptide were uncleaved ."
],
"offsets": [
[
0,
225
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28455
|
split_0_train_28455
|
[
{
"id": "split_0_train_28455_passage",
"type": "progene_text",
"text": [
"While the polypeptide expressed from the cDNA containing both the signal peptide and GPI anchor signal was truncated by approximately 14 kDa at the C - terminus , the polypeptide derived from the cDNA with only the signal peptide was processed to remove approximately 6 kDa , also from the C-terminus ."
],
"offsets": [
[
0,
302
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28456
|
split_0_train_28456
|
[
{
"id": "split_0_train_28456_passage",
"type": "progene_text",
"text": [
"Furthermore , the polypeptides derived from cDNAs that lacked the signal peptide were exclusively localized intra - cellularly , the polypeptides from cDNAs that contained the signal peptide were predominantly intracellular , with low levels on the cell surface ; none of the polypeptides was secreted into the culture medium to a detectable level.These results suggest that N - glycosylation alone is not sufficient for the efficient extracellular transport of the recombinant MSP-1 polypeptides through the secretory pathway in mammalian cells ."
],
"offsets": [
[
0,
547
]
]
}
] |
[
{
"id": "split_0_train_46056_entity",
"type": "progene_text",
"text": [
"MSP-1"
],
"offsets": [
[
478,
483
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28457
|
split_0_train_28457
|
[
{
"id": "split_0_train_28457_passage",
"type": "progene_text",
"text": [
"Human CD8 beta , but not mouse CD8 beta , can be expressed in the absence of CD8 alpha as a beta beta homodimer ."
],
"offsets": [
[
0,
113
]
]
}
] |
[
{
"id": "split_0_train_46057_entity",
"type": "progene_text",
"text": [
"CD8 beta"
],
"offsets": [
[
6,
14
]
],
"normalized": []
},
{
"id": "split_0_train_46058_entity",
"type": "progene_text",
"text": [
"CD8 beta"
],
"offsets": [
[
31,
39
]
],
"normalized": []
},
{
"id": "split_0_train_46059_entity",
"type": "progene_text",
"text": [
"CD8 alpha"
],
"offsets": [
[
77,
86
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28458
|
split_0_train_28458
|
[
{
"id": "split_0_train_28458_passage",
"type": "progene_text",
"text": [
"The T cell coreceptor CD8 exists on mature T cells as disulfide - linked homodimers of CD8 alpha polypeptide chains and heterodimers of CD8 alpha - and CD8 beta - chains ."
],
"offsets": [
[
0,
171
]
]
}
] |
[
{
"id": "split_0_train_46060_entity",
"type": "progene_text",
"text": [
"CD8"
],
"offsets": [
[
22,
25
]
],
"normalized": []
},
{
"id": "split_0_train_46061_entity",
"type": "progene_text",
"text": [
"CD8 alpha"
],
"offsets": [
[
87,
96
]
],
"normalized": []
},
{
"id": "split_0_train_46062_entity",
"type": "progene_text",
"text": [
"CD8 alpha"
],
"offsets": [
[
136,
145
]
],
"normalized": []
},
{
"id": "split_0_train_46063_entity",
"type": "progene_text",
"text": [
"CD8 beta"
],
"offsets": [
[
152,
160
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28459
|
split_0_train_28459
|
[
{
"id": "split_0_train_28459_passage",
"type": "progene_text",
"text": [
"The function of the CD8 alpha - chain for binding to MHC class I and associating with the tyrosine kinase p56lck was demonstrated with CD8 alpha alpha homodimers ."
],
"offsets": [
[
0,
163
]
]
}
] |
[
{
"id": "split_0_train_46064_entity",
"type": "progene_text",
"text": [
"CD8 alpha"
],
"offsets": [
[
20,
29
]
],
"normalized": []
},
{
"id": "split_0_train_46065_entity",
"type": "progene_text",
"text": [
"MHC class I"
],
"offsets": [
[
53,
64
]
],
"normalized": []
},
{
"id": "split_0_train_46066_entity",
"type": "progene_text",
"text": [
"tyrosine kinase"
],
"offsets": [
[
90,
105
]
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"text": [
"CD8 alpha"
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135,
144
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}
] |
[] |
[] |
[] |
split_0_train_28460
|
split_0_train_28460
|
[
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"id": "split_0_train_28460_passage",
"type": "progene_text",
"text": [
"CD8 alpha beta functions as a better coreceptor , but the actual function of CD8 beta is less clear ."
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0,
101
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{
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"text": [
"CD8 beta"
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77,
85
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}
] |
[] |
[] |
[] |
split_0_train_28461
|
split_0_train_28461
|
[
{
"id": "split_0_train_28461_passage",
"type": "progene_text",
"text": [
"Addressing this issue has been hampered by the apparent inability of CD8 beta to be expressed without CD8 alpha ."
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0,
113
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}
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{
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"text": [
"CD8 alpha"
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102,
111
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}
] |
[] |
[] |
[] |
split_0_train_28462
|
split_0_train_28462
|
[
{
"id": "split_0_train_28462_passage",
"type": "progene_text",
"text": [
"This study demonstrates that human , but not mouse , CD8 beta can be expressed on the cell surface without CD8 alpha in both transfected COS-7 cells and murine lymphocytes ."
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[
0,
173
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}
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{
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"text": [
"CD8 alpha"
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107,
116
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}
] |
[] |
[] |
[] |
split_0_train_28463
|
split_0_train_28463
|
[
{
"id": "split_0_train_28463_passage",
"type": "progene_text",
"text": [
"By creating chimeric proteins , we show that the murine Ig domain of CD8 beta is responsible for the lack of expression of murine CD8 beta beta dimers ."
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[
0,
152
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]
}
] |
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{
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"text": [
"CD8 beta"
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130,
138
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}
] |
[] |
[] |
[] |
split_0_train_28464
|
split_0_train_28464
|
[
{
"id": "split_0_train_28464_passage",
"type": "progene_text",
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"In contrast to CD8 alpha alpha , CD8 beta beta is unable to bind MHC class I in a cell - cell adhesion assay ."
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[
0,
110
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}
] |
[
{
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15,
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"text": [
"MHC class I"
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[
65,
76
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28465
|
split_0_train_28465
|
[
{
"id": "split_0_train_28465_passage",
"type": "progene_text",
"text": [
"Detection of this form of CD8 should facilitate studies on the function of the CD8 beta - chain and indicates that caution should be used when interpreting studies on CD8 function using chimeric protein with the murine CD8 beta beta Ig domain ."
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[
0,
244
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]
}
] |
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{
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26,
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219,
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"type": "progene_text",
"text": [
"Ig"
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"offsets": [
[
233,
235
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28466
|
split_0_train_28466
|
[
{
"id": "split_0_train_28466_passage",
"type": "progene_text",
"text": [
"In addition , we demonstrate that the Ig domains of CD8 alpha are also involved in controlling the ability of CD8 to be expressed ."
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[
0,
131
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]
}
] |
[
{
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38,
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52,
61
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{
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"type": "progene_text",
"text": [
"CD8"
],
"offsets": [
[
110,
113
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28467
|
split_0_train_28467
|
[
{
"id": "split_0_train_28467_passage",
"type": "progene_text",
"text": [
"Mutation of B - and F - strand cysteine residues in CD8 alpha reduced the ability of the protein to fold properly and , therefore , to be expressed ."
],
"offsets": [
[
0,
149
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]
}
] |
[
{
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"type": "progene_text",
"text": [
"CD8 alpha"
],
"offsets": [
[
52,
61
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28468
|
split_0_train_28468
|
[
{
"id": "split_0_train_28468_passage",
"type": "progene_text",
"text": [
"Endothelin - dependent and - independent components of strain - activated brain natriuretic peptide gene transcription require extracellular signal regulated kinase and p38 mitogen - activated protein kinase ."
],
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[
0,
209
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]
}
] |
[
{
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{
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{
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{
"id": "split_0_train_46093_entity",
"type": "progene_text",
"text": [
"p38 mitogen - activated protein kinase"
],
"offsets": [
[
169,
207
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28469
|
split_0_train_28469
|
[
{
"id": "split_0_train_28469_passage",
"type": "progene_text",
"text": [
"The application of mechanical strain to cultured cardiac myocytes in vitro leads to activation of the brain natriuretic peptide ( BNP ) gene promoter , a marker of cardiac hypertrophy ."
],
"offsets": [
[
0,
185
]
]
}
] |
[
{
"id": "split_0_train_46094_entity",
"type": "progene_text",
"text": [
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102,
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{
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"type": "progene_text",
"text": [
"BNP"
],
"offsets": [
[
130,
133
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28470
|
split_0_train_28470
|
[
{
"id": "split_0_train_28470_passage",
"type": "progene_text",
"text": [
"We have previously shown that this activation results from both a direct mechanostimulatory event and an indirect autocrine / paracrine stimulation involving the sequential production of angiotensin II and endothelin ( ET ) ."
],
"offsets": [
[
0,
225
]
]
}
] |
[
{
"id": "split_0_train_46096_entity",
"type": "progene_text",
"text": [
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187,
201
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{
"id": "split_0_train_46097_entity",
"type": "progene_text",
"text": [
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206,
216
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{
"id": "split_0_train_46098_entity",
"type": "progene_text",
"text": [
"ET"
],
"offsets": [
[
219,
221
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28471
|
split_0_train_28471
|
[
{
"id": "split_0_train_28471_passage",
"type": "progene_text",
"text": [
"In the present study , we examined the role of p38 mitogen - activated protein kinase ( MAPK ) and extracellular signal regulated kinase ( ERK ) in signaling the increase in promoter activity trafficking through each of these pathways ."
],
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[
0,
236
]
]
}
] |
[
{
"id": "split_0_train_46099_entity",
"type": "progene_text",
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{
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"type": "progene_text",
"text": [
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88,
92
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{
"id": "split_0_train_46101_entity",
"type": "progene_text",
"text": [
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99,
136
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{
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"type": "progene_text",
"text": [
"ERK"
],
"offsets": [
[
139,
142
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28472
|
split_0_train_28472
|
[
{
"id": "split_0_train_28472_passage",
"type": "progene_text",
"text": [
"ET was shown to stimulate both p38 MAPK and ERK activity in these cultures and to activate human BNP ( hBNP ) promoter activity ."
],
"offsets": [
[
0,
129
]
]
}
] |
[
{
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"type": "progene_text",
"text": [
"ET"
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[
0,
2
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},
{
"id": "split_0_train_46104_entity",
"type": "progene_text",
"text": [
"p38 MAPK"
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31,
39
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{
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"type": "progene_text",
"text": [
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44,
47
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},
{
"id": "split_0_train_46106_entity",
"type": "progene_text",
"text": [
"BNP"
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97,
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},
{
"id": "split_0_train_46107_entity",
"type": "progene_text",
"text": [
"hBNP"
],
"offsets": [
[
103,
107
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28473
|
split_0_train_28473
|
[
{
"id": "split_0_train_28473_passage",
"type": "progene_text",
"text": [
"Activation of the promoter was inhibited approximately 45 % by SB - 203580 , a p38 MAPK inhibitor , and approximately 70 % by PD98059 , an inhibitor of the ERK - activating kinase MAPK kinase ."
],
"offsets": [
[
0,
193
]
]
}
] |
[
{
"id": "split_0_train_46108_entity",
"type": "progene_text",
"text": [
"p38 MAPK"
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79,
87
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},
{
"id": "split_0_train_46109_entity",
"type": "progene_text",
"text": [
"ERK - activating kinase"
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156,
179
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},
{
"id": "split_0_train_46110_entity",
"type": "progene_text",
"text": [
"MAPK kinase"
],
"offsets": [
[
180,
191
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28474
|
split_0_train_28474
|
[
{
"id": "split_0_train_28474_passage",
"type": "progene_text",
"text": [
"The ET - independent ( ie , direct ) stimulation of the hBNP promoter by mechanical strain was inhibited approximately 70 % by SB - 203580 and approximately 60 % by PD98059 , implying that similar signaling circuitry is used , albeit to different degrees , by the direct and indirect pathways ."
],
"offsets": [
[
0,
294
]
]
}
] |
[
{
"id": "split_0_train_46111_entity",
"type": "progene_text",
"text": [
"ET"
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"offsets": [
[
4,
6
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],
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},
{
"id": "split_0_train_46112_entity",
"type": "progene_text",
"text": [
"hBNP"
],
"offsets": [
[
56,
60
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28475
|
split_0_train_28475
|
[
{
"id": "split_0_train_28475_passage",
"type": "progene_text",
"text": [
"The p38 MAPK component of both the ET - dependent and the ET - independent responses to strain appears to operate through a series of nuclear factor - kappaB binding , shear stress response element - like structures in the hBNP gene promoter ."
],
"offsets": [
[
0,
243
]
]
}
] |
[
{
"id": "split_0_train_46113_entity",
"type": "progene_text",
"text": [
"p38 MAPK"
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[
4,
12
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},
{
"id": "split_0_train_46114_entity",
"type": "progene_text",
"text": [
"ET"
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35,
37
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},
{
"id": "split_0_train_46115_entity",
"type": "progene_text",
"text": [
"ET"
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[
58,
60
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],
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},
{
"id": "split_0_train_46116_entity",
"type": "progene_text",
"text": [
"nuclear factor - kappaB"
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[
134,
157
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],
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},
{
"id": "split_0_train_46117_entity",
"type": "progene_text",
"text": [
"hBNP"
],
"offsets": [
[
223,
227
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28476
|
split_0_train_28476
|
[
{
"id": "split_0_train_28476_passage",
"type": "progene_text",
"text": [
"Collectively , these data suggest that activation of the BNP promoter by hypertrophic stimuli involves the participation of several independent signaling pathways ."
],
"offsets": [
[
0,
164
]
]
}
] |
[
{
"id": "split_0_train_46118_entity",
"type": "progene_text",
"text": [
"BNP"
],
"offsets": [
[
57,
60
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28477
|
split_0_train_28477
|
[
{
"id": "split_0_train_28477_passage",
"type": "progene_text",
"text": [
"Such redundancy would help to guarantee generation of the full hypertrophic phenotype independently of the nature of the hypertrophic stimulus ."
],
"offsets": [
[
0,
144
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28478
|
split_0_train_28478
|
[
{
"id": "split_0_train_28478_passage",
"type": "progene_text",
"text": [
"Development of catechol 2,3-dioxygenase - specific primers for monitoring bioremediation by competitive quantitative PCR ."
],
"offsets": [
[
0,
122
]
]
}
] |
[
{
"id": "split_0_train_46119_entity",
"type": "progene_text",
"text": [
"catechol 2,3-dioxygenase"
],
"offsets": [
[
15,
39
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28479
|
split_0_train_28479
|
[
{
"id": "split_0_train_28479_passage",
"type": "progene_text",
"text": [
"Benzene , toluene , xylenes , phenol , naphthalene , and biphenyl are among a group of compounds that have at least one reported pathway for biodegradation involving catechol 2,3-dioxygenase enzymes ."
],
"offsets": [
[
0,
200
]
]
}
] |
[
{
"id": "split_0_train_46120_entity",
"type": "progene_text",
"text": [
"catechol 2,3-dioxygenase"
],
"offsets": [
[
166,
190
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28480
|
split_0_train_28480
|
[
{
"id": "split_0_train_28480_passage",
"type": "progene_text",
"text": [
"Thus , detection of the corresponding catechol 2,3-dioxygenase genes can serve as a basis for identifying and quantifying bacteria that have these catabolic abilities ."
],
"offsets": [
[
0,
168
]
]
}
] |
[
{
"id": "split_0_train_46121_entity",
"type": "progene_text",
"text": [
"catechol 2,3-dioxygenase"
],
"offsets": [
[
38,
62
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28481
|
split_0_train_28481
|
[
{
"id": "split_0_train_28481_passage",
"type": "progene_text",
"text": [
"Primers that can successfully amplify a 238 - bp catechol 2,3-dioxygenase gene fragment from eight different bacteria are described ."
],
"offsets": [
[
0,
133
]
]
}
] |
[
{
"id": "split_0_train_46122_entity",
"type": "progene_text",
"text": [
"catechol 2,3-dioxygenase"
],
"offsets": [
[
49,
73
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28482
|
split_0_train_28482
|
[
{
"id": "split_0_train_28482_passage",
"type": "progene_text",
"text": [
"The identities of the amplicons were confirmed by hybridization with a 238 - bp catechol 2,3-dioxygenase probe ."
],
"offsets": [
[
0,
112
]
]
}
] |
[
{
"id": "split_0_train_46123_entity",
"type": "progene_text",
"text": [
"catechol 2,3-dioxygenase"
],
"offsets": [
[
80,
104
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28483
|
split_0_train_28483
|
[
{
"id": "split_0_train_28483_passage",
"type": "progene_text",
"text": [
"The detection limit was 10(2) to 10(3) gene copies , which was lowered to 10 ( 0 ) to 10(1) gene copies by hybridization ."
],
"offsets": [
[
0,
122
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28484
|
split_0_train_28484
|
[
{
"id": "split_0_train_28484_passage",
"type": "progene_text",
"text": [
"Using the dioxygenase - specific primers , an increase in catechol 2 , 3-dioxygenase genes was detected in petroleum - amended soils ."
],
"offsets": [
[
0,
134
]
]
}
] |
[
{
"id": "split_0_train_46124_entity",
"type": "progene_text",
"text": [
"dioxygenase"
],
"offsets": [
[
10,
21
]
],
"normalized": []
},
{
"id": "split_0_train_46125_entity",
"type": "progene_text",
"text": [
"catechol 2 , 3-dioxygenase"
],
"offsets": [
[
58,
84
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28485
|
split_0_train_28485
|
[
{
"id": "split_0_train_28485_passage",
"type": "progene_text",
"text": [
"The dioxygenase genes were enumerated by competitive quantitative PCR with a 163 - bp competitor that was amplified using the same primers ."
],
"offsets": [
[
0,
140
]
]
}
] |
[
{
"id": "split_0_train_46126_entity",
"type": "progene_text",
"text": [
"dioxygenase"
],
"offsets": [
[
4,
15
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28486
|
split_0_train_28486
|
[
{
"id": "split_0_train_28486_passage",
"type": "progene_text",
"text": [
"Target and competitor sequences had identical amplification kinetics ."
],
"offsets": [
[
0,
70
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28487
|
split_0_train_28487
|
[
{
"id": "split_0_train_28487_passage",
"type": "progene_text",
"text": [
"Potential PCR inhibitors that could coextract with DNA , nonamplifying DNA , soil factors ( humics ) , and soil pollutants ( toluene ) did not impact enumeration ."
],
"offsets": [
[
0,
163
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28488
|
split_0_train_28488
|
[
{
"id": "split_0_train_28488_passage",
"type": "progene_text",
"text": [
"Therefore , this technique can be used to accurately and reproducibly quantify catechol 2 , 3-dioxygenase genes in complex environments such as petroleum - contaminated soil ."
],
"offsets": [
[
0,
175
]
]
}
] |
[
{
"id": "split_0_train_46127_entity",
"type": "progene_text",
"text": [
"catechol 2 , 3-dioxygenase"
],
"offsets": [
[
79,
105
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28489
|
split_0_train_28489
|
[
{
"id": "split_0_train_28489_passage",
"type": "progene_text",
"text": [
"Direct , non - cultivation - based molecular techniques for detecting and enumerating microbial pollutant - biodegrading genes in environmental samples are powerful tools for monitoring bioremediation and developing field evidence in support of natural attenuation ."
],
"offsets": [
[
0,
266
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28490
|
split_0_train_28490
|
[
{
"id": "split_0_train_28490_passage",
"type": "progene_text",
"text": [
"Steroid dehydrogenase structures , mechanism of action , and disease ."
],
"offsets": [
[
0,
70
]
]
}
] |
[
{
"id": "split_0_train_46128_entity",
"type": "progene_text",
"text": [
"Steroid dehydrogenase"
],
"offsets": [
[
0,
21
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28491
|
split_0_train_28491
|
[
{
"id": "split_0_train_28491_passage",
"type": "progene_text",
"text": [
"Steroid dehydrogenase enzymes influence mammalian reproduction , hypertension , neoplasia , and digestion ."
],
"offsets": [
[
0,
107
]
]
}
] |
[
{
"id": "split_0_train_46129_entity",
"type": "progene_text",
"text": [
"Steroid dehydrogenase"
],
"offsets": [
[
0,
21
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28492
|
split_0_train_28492
|
[
{
"id": "split_0_train_28492_passage",
"type": "progene_text",
"text": [
"The three - dimensional structures of steroid dehydrogenase enzymes reveal the position of the catalytic triad , a possible mechanism of keto - hydroxyl interconversion , a molecular mechanism of inhibition , and the basis for selectivity ."
],
"offsets": [
[
0,
240
]
]
}
] |
[
{
"id": "split_0_train_46130_entity",
"type": "progene_text",
"text": [
"steroid dehydrogenase"
],
"offsets": [
[
38,
59
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28493
|
split_0_train_28493
|
[
{
"id": "split_0_train_28493_passage",
"type": "progene_text",
"text": [
"Glycyrrhizic acid , the active ingredient in licorice , and its metabolite carbenoxolone are potent inhibitors of human 11 beta-hydroxysteroid dehydrogenase and bacterial 3 alpha , 20 beta-hydroxysteroid dehydrogenase ( 3 alpha , 20 beta-HSD ) ."
],
"offsets": [
[
0,
245
]
]
}
] |
[
{
"id": "split_0_train_46131_entity",
"type": "progene_text",
"text": [
"11 beta-hydroxysteroid dehydrogenase"
],
"offsets": [
[
120,
156
]
],
"normalized": []
},
{
"id": "split_0_train_46132_entity",
"type": "progene_text",
"text": [
"3 alpha , 20 beta-hydroxysteroid dehydrogenase"
],
"offsets": [
[
171,
217
]
],
"normalized": []
},
{
"id": "split_0_train_46133_entity",
"type": "progene_text",
"text": [
"3 alpha , 20 beta-HSD"
],
"offsets": [
[
220,
241
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28494
|
split_0_train_28494
|
[
{
"id": "split_0_train_28494_passage",
"type": "progene_text",
"text": [
"The three - dimensional structure of the 3 alpha , 20 beta-HSD carbenoxolone complex unequivocally verifies the postulated active site of the enzyme , shows that inhibition is a result of direct competition with the substrate for binding , and provides a plausible model for the mechanism of inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone ."
],
"offsets": [
[
0,
361
]
]
}
] |
[
{
"id": "split_0_train_46134_entity",
"type": "progene_text",
"text": [
"3 alpha , 20 beta-HSD"
],
"offsets": [
[
41,
62
]
],
"normalized": []
},
{
"id": "split_0_train_46135_entity",
"type": "progene_text",
"text": [
"11 beta-hydroxysteroid dehydrogenase"
],
"offsets": [
[
306,
342
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28495
|
split_0_train_28495
|
[
{
"id": "split_0_train_28495_passage",
"type": "progene_text",
"text": [
"The structure of the ternary complex of human 17 beta-hydroxysteroid dehydrogenase type 1 ( 17 beta-HSD ) with the cofactor NADP + and the antiestrogen equilin reveals the details of binding of an inhibitor in the active site of the enzyme and the possible roles of various amino acids in the catalytic cleft ."
],
"offsets": [
[
0,
310
]
]
}
] |
[
{
"id": "split_0_train_46136_entity",
"type": "progene_text",
"text": [
"17 beta-hydroxysteroid dehydrogenase type 1"
],
"offsets": [
[
46,
89
]
],
"normalized": []
},
{
"id": "split_0_train_46137_entity",
"type": "progene_text",
"text": [
"17 beta-HSD"
],
"offsets": [
[
92,
103
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28496
|
split_0_train_28496
|
[
{
"id": "split_0_train_28496_passage",
"type": "progene_text",
"text": [
"The short - chain dehydrogenase reductase ( SDR ) family includes these steroid dehydrogenase enzymes and more than 60 other proteins from human , mammalian , insect , and bacterial sources ."
],
"offsets": [
[
0,
191
]
]
}
] |
[
{
"id": "split_0_train_46138_entity",
"type": "progene_text",
"text": [
"short - chain dehydrogenase reductase ( SDR ) family"
],
"offsets": [
[
4,
56
]
],
"normalized": []
},
{
"id": "split_0_train_46139_entity",
"type": "progene_text",
"text": [
"steroid dehydrogenase"
],
"offsets": [
[
72,
93
]
],
"normalized": []
}
] |
[] |
[] |
[] |
split_0_train_28497
|
split_0_train_28497
|
[
{
"id": "split_0_train_28497_passage",
"type": "progene_text",
"text": [
"Most members of the family contain the tyrosine and lysine of the catalytic triad in a YxxxK sequence ."
],
"offsets": [
[
0,
103
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28498
|
split_0_train_28498
|
[
{
"id": "split_0_train_28498_passage",
"type": "progene_text",
"text": [
"X-ray crystal structures of 13 members of the family have been completed ."
],
"offsets": [
[
0,
74
]
]
}
] |
[] |
[] |
[] |
[] |
split_0_train_28499
|
split_0_train_28499
|
[
{
"id": "split_0_train_28499_passage",
"type": "progene_text",
"text": [
"When the alpha-carbon backbone of the cofactor binding domains of the structures are superimposed , the conserved residues are at the core of the structure and in the cofactor binding domain , but not in the substrate binding pocket ."
],
"offsets": [
[
0,
234
]
]
}
] |
[] |
[] |
[] |
[] |
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